Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled photoreceptor activity	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	1.50e-08	15	38	4	GO:0008020
GeneOntologyMolecularFunction	photoreceptor activity	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	2.61e-08	17	38	4	GO:0009881
GeneOntologyMolecularFunction	glycogenin glucosyltransferase activity	GYG2 GYG1	3.53e-06	2	38	2	GO:0008466
GeneOntologyMolecularFunction	co-SMAD binding	SMAD2 SMAD3	2.30e-04	12	38	2	GO:0070410
GeneOntologyMolecularFunction	UDP-glucosyltransferase activity	GYG2 GYG1	2.71e-04	13	38	2	GO:0035251
GeneOntologyMolecularFunction	I-SMAD binding	SMAD2 SMAD3	4.71e-04	17	38	2	GO:0070411
GeneOntologyMolecularFunction	glucosyltransferase activity	GYG2 GYG1	7.95e-04	22	38	2	GO:0046527
GeneOntologyMolecularFunction	R-SMAD binding	SMAD2 SMAD3	1.11e-03	26	38	2	GO:0070412
GeneOntologyMolecularFunction	transforming growth factor beta receptor binding	SMAD2 SMAD3	1.58e-03	31	38	2	GO:0005160
GeneOntologyMolecularFunction	calcium ion binding	SELE PLCD4 CUBN VCAN NOTCH3 CAPN3	2.70e-03	749	38	6	GO:0005509
GeneOntologyMolecularFunction	carbohydrate binding	SELE MRC1 GYG1 VCAN	2.77e-03	310	38	4	GO:0030246
GeneOntologyBiologicalProcess	phototransduction	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	2.69e-06	53	38	4	GO:0007602
GeneOntologyBiologicalProcess	detection of visible light	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	3.61e-06	57	38	4	GO:0009584
GeneOntologyBiologicalProcess	detection of light stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	1.20e-05	77	38	4	GO:0009583
GeneOntologyBiologicalProcess	cellular response to abiotic stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW RPTOR CAPN3	5.52e-05	371	38	6	GO:0071214
GeneOntologyBiologicalProcess	cellular response to environmental stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW RPTOR CAPN3	5.52e-05	371	38	6	GO:0104004
GeneOntologyBiologicalProcess	cellular response to light stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	9.42e-05	130	38	4	GO:0071482
GeneOntologyBiologicalProcess	positive regulation of cytokinesis	OPN1MW2 OPN1LW OPN1MW	1.42e-04	55	38	3	GO:0032467
GeneOntologyBiologicalProcess	embryonic foregut morphogenesis	SMAD2 SMAD3	1.80e-04	11	38	2	GO:0048617
GeneOntologyBiologicalProcess	positive regulation of epithelial to mesenchymal transition	TIAM1 SMAD2 SMAD3	2.12e-04	63	38	3	GO:0010718
GeneOntologyBiologicalProcess	foregut morphogenesis	SMAD2 SMAD3	2.16e-04	12	38	2	GO:0007440
GeneOntologyBiologicalProcess	paraxial mesoderm morphogenesis	SMAD2 SMAD3	2.55e-04	13	38	2	GO:0048340
GeneOntologyBiologicalProcess	detection of external stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	2.82e-04	173	38	4	GO:0009581
GeneOntologyBiologicalProcess	detection of abiotic stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	2.95e-04	175	38	4	GO:0009582
GeneOntologyBiologicalProcess	glucose homeostasis	CSMD1 TIAM1 RPTOR SMAD2 SMAD3	3.69e-04	338	38	5	GO:0042593
GeneOntologyBiologicalProcess	carbohydrate homeostasis	CSMD1 TIAM1 RPTOR SMAD2 SMAD3	3.74e-04	339	38	5	GO:0033500
GeneOntologyBiologicalProcess	cellular response to radiation	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	4.36e-04	194	38	4	GO:0071478
GeneOntologyBiologicalProcess	cellular response to glucose stimulus	TIAM1 RPTOR SMAD2 SMAD3	4.53e-04	196	38	4	GO:0071333
GeneOntologyBiologicalProcess	mesoderm formation	AHDC1 SMAD2 SMAD3	4.62e-04	82	38	3	GO:0001707
GeneOntologyBiologicalProcess	cellular response to hexose stimulus	TIAM1 RPTOR SMAD2 SMAD3	4.80e-04	199	38	4	GO:0071331
GeneOntologyBiologicalProcess	cellular response to monosaccharide stimulus	TIAM1 RPTOR SMAD2 SMAD3	4.98e-04	201	38	4	GO:0071326
GeneOntologyBiologicalProcess	mesoderm morphogenesis	AHDC1 SMAD2 SMAD3	5.31e-04	86	38	3	GO:0048332
GeneOntologyBiologicalProcess	odontoblast differentiation	RPTOR SMAD2	5.54e-04	19	38	2	GO:0071895
GeneOntologyBiologicalProcess	primary miRNA processing	SMAD2 SMAD3	6.15e-04	20	38	2	GO:0031053
GeneOntologyBiologicalProcess	cellular response to carbohydrate stimulus	TIAM1 RPTOR SMAD2 SMAD3	6.42e-04	215	38	4	GO:0071322
GeneOntologyBiologicalProcess	intracellular glucose homeostasis	TIAM1 RPTOR SMAD2 SMAD3	6.76e-04	218	38	4	GO:0001678
GeneOntologyBiologicalProcess	regulation of binding	CFHR5 TIAM1 ZNF618 SMAD2 SMAD3	7.58e-04	396	38	5	GO:0051098
GeneOntologyBiologicalProcess	regulation of cytokinesis	OPN1MW2 OPN1LW OPN1MW	8.01e-04	99	38	3	GO:0032465
GeneOntologyBiologicalProcess	visual perception	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	8.26e-04	230	38	4	GO:0007601
GeneOntologyBiologicalProcess	sensory perception of light stimulus	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	8.67e-04	233	38	4	GO:0050953
GeneOntologyBiologicalProcess	paraxial mesoderm development	SMAD2 SMAD3	8.89e-04	24	38	2	GO:0048339
GeneOntologyBiologicalProcess	positive regulation of cell division	OPN1MW2 OPN1LW OPN1MW	9.24e-04	104	38	3	GO:0051781
GeneOntologyBiologicalProcess	nodal signaling pathway	SMAD2 SMAD3	1.04e-03	26	38	2	GO:0038092
GeneOntologyBiologicalProcess	pericardium development	SMAD2 SMAD3	1.21e-03	28	38	2	GO:0060039
GeneOntologyBiologicalProcess	signal transduction involved in regulation of gene expression	SMAD2 SMAD3	1.21e-03	28	38	2	GO:0023019
GeneOntologyBiologicalProcess	response to glucose	TIAM1 RPTOR SMAD2 SMAD3	1.30e-03	260	38	4	GO:0009749
GeneOntologyBiologicalProcess	adrenal gland development	SMAD2 SMAD3	1.30e-03	29	38	2	GO:0030325
GeneOntologyBiologicalProcess	response to hexose	TIAM1 RPTOR SMAD2 SMAD3	1.39e-03	265	38	4	GO:0009746
GeneOntologyBiologicalProcess	formation of primary germ layer	AHDC1 SMAD2 SMAD3	1.53e-03	124	38	3	GO:0001704
GeneOntologyBiologicalProcess	response to monosaccharide	TIAM1 RPTOR SMAD2 SMAD3	1.53e-03	272	38	4	GO:0034284
GeneOntologyCellularComponent	photoreceptor disc membrane	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	1.35e-07	26	38	4	GO:0097381
GeneOntologyCellularComponent	non-motile cilium	OPN1MW2 OPN1LW OPN1MW3 OPN1MW TIAM1 VCAN	1.35e-06	196	38	6	GO:0097730
GeneOntologyCellularComponent	photoreceptor outer segment	OPN1MW2 OPN1LW OPN1MW3 OPN1MW VCAN	1.68e-06	111	38	5	GO:0001750
GeneOntologyCellularComponent	photoreceptor cell cilium	OPN1MW2 OPN1LW OPN1MW3 OPN1MW VCAN	5.09e-06	139	38	5	GO:0097733
GeneOntologyCellularComponent	9+0 non-motile cilium	OPN1MW2 OPN1LW OPN1MW3 OPN1MW VCAN	8.13e-06	153	38	5	GO:0097731
GeneOntologyCellularComponent	heteromeric SMAD protein complex	SMAD2 SMAD3	8.95e-05	8	38	2	GO:0071144
GeneOntologyCellularComponent	SMAD protein complex	SMAD2 SMAD3	1.43e-04	10	38	2	GO:0071141
GeneOntologyCellularComponent	cilium	OPN1MW2 OPN1LW OPN1MW3 FBXL13 OPN1MW TIAM1 DNAH9 VCAN	1.74e-04	898	38	8	GO:0005929
GeneOntologyCellularComponent	lysosomal lumen	CUBN GYG1 VCAN	7.48e-04	98	38	3	GO:0043202
HumanPheno	Blue cone monochromacy	OPN1LW OPN1MW	9.25e-06	2	16	2	HP:0007939
HumanPheno	Cone monochromacy	OPN1LW OPN1MW	9.25e-06	2	16	2	HP:0011517
HumanPheno	Reduced OCT-measured foveal thickness	OPN1LW OPN1MW	2.77e-05	3	16	2	HP:0030619
HumanPheno	Dural ectasia	NOTCH3 SMAD2 SMAD3	4.94e-05	24	16	3	HP:0100775
HumanPheno	Abnormal OCT-measured foveal thickness	OPN1LW OPN1MW	5.53e-05	4	16	2	HP:0030617
HumanPheno	Abnormal spinal meningeal morphology	NOTCH3 SMAD2 SMAD3	5.61e-05	25	16	3	HP:0010303
HumanPheno	Pelvic girdle amyotrophy	GYG1 CAPN3	9.20e-05	5	16	2	HP:0008946
HumanPheno	Varicose veins	NOTCH3 SMAD2 SMAD3	1.19e-04	32	16	3	HP:0002619
HumanPheno	Intervertebral disk degeneration	SMAD2 SMAD3	1.38e-04	6	16	2	HP:0008419
HumanPheno	Unbalanced atrioventricular canal defect	DNAH9 SMAD2	1.38e-04	6	16	2	HP:0011579
HumanPheno	Osteochondritis dissecans	SMAD2 SMAD3	1.92e-04	7	16	2	HP:0010886
HumanPheno	Ischemic stroke	NOTCH3 SMAD2 SMAD3	2.01e-04	38	16	3	HP:0002140
HumanPheno	Cerebral infarct	NOTCH3 SMAD2 SMAD3	2.17e-04	39	16	3	HP:0025722
HumanPheno	Venous insufficiency	NOTCH3 SMAD2 SMAD3	2.34e-04	40	16	3	HP:0005293
HumanPheno	Isomerism	DNAH9 SMAD2	2.56e-04	8	16	2	HP:0031853
HumanPheno	Aortic tortuosity	SMAD2 SMAD3	2.56e-04	8	16	2	HP:0006687
HumanPheno	Abnormal foveal morphology on macular OCT	OPN1LW OPN1MW	2.56e-04	8	16	2	HP:0030613
HumanPheno	Uterine rupture	SMAD2 SMAD3	3.29e-04	9	16	2	HP:0100718
HumanPheno	Eccentric visual fixation	OPN1LW OPN1MW	4.10e-04	10	16	2	HP:0025549
HumanPheno	Red-green dyschromatopsia	OPN1LW OPN1MW	5.00e-04	11	16	2	HP:0000642
HumanPheno	Anomalous trichromacy	OPN1LW OPN1MW	5.00e-04	11	16	2	HP:0011519
HumanPheno	Monochromacy	OPN1LW OPN1MW	5.00e-04	11	16	2	HP:0007803
HumanPheno	Arterial dissection	SMAD2 SMAD3	5.99e-04	12	16	2	HP:0005294
HumanPheno	Osteochondrosis	SMAD2 SMAD3	5.99e-04	12	16	2	HP:0040188
HumanPheno	Transient ischemic attack	NOTCH3 SMAD2 SMAD3	8.19e-04	61	16	3	HP:0002326
HumanPheno	Knee osteoarthritis	SMAD2 SMAD3	9.48e-04	15	16	2	HP:0005086
Domain	Opsin_red/grn	OPN1LW OPN1MW3 OPN1MW	7.16e-09	3	37	3	IPR000378
Domain	Sushi	SELE CFHR5 CSMD1 CSMD2 VCAN	5.60e-08	52	37	5	PF00084
Domain	CCP	SELE CFHR5 CSMD1 CSMD2 VCAN	6.79e-08	54	37	5	SM00032
Domain	SUSHI	SELE CFHR5 CSMD1 CSMD2 VCAN	8.18e-08	56	37	5	PS50923
Domain	Sushi_SCR_CCP_dom	SELE CFHR5 CSMD1 CSMD2 VCAN	8.95e-08	57	37	5	IPR000436
Domain	OPSIN	OPN1LW OPN1MW3 OPN1MW	8.51e-07	10	37	3	PS00238
Domain	Opsin	OPN1LW OPN1MW3 OPN1MW	1.17e-06	11	37	3	IPR001760
Domain	CUB	TMPRSS15 CUBN CSMD1 CSMD2	2.59e-06	49	37	4	PF00431
Domain	CUB	TMPRSS15 CUBN CSMD1 CSMD2	2.81e-06	50	37	4	SM00042
Domain	-	TMPRSS15 CUBN CSMD1 CSMD2	3.30e-06	52	37	4	2.60.120.290
Domain	CUB	TMPRSS15 CUBN CSMD1 CSMD2	3.56e-06	53	37	4	PS01180
Domain	CUB_dom	TMPRSS15 CUBN CSMD1 CSMD2	4.78e-06	57	37	4	IPR000859
Domain	C-type_lectin_CS	SELE MRC1 VCAN	8.36e-05	43	37	3	IPR018378
Domain	Dwarfin	SMAD2 SMAD3	1.06e-04	8	37	2	IPR013790
Domain	DWB	SMAD2 SMAD3	1.06e-04	8	37	2	SM00524
Domain	-	SMAD2 SMAD3	1.06e-04	8	37	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD2 SMAD3	1.06e-04	8	37	2	IPR013019
Domain	MH2	SMAD2 SMAD3	1.06e-04	8	37	2	PS51076
Domain	MH1	SMAD2 SMAD3	1.06e-04	8	37	2	PS51075
Domain	MH2	SMAD2 SMAD3	1.06e-04	8	37	2	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD2 SMAD3	1.06e-04	8	37	2	IPR001132
Domain	EGF	SELE CUBN VCAN NOTCH3	1.10e-04	126	37	4	PF00008
Domain	Glyco_trans_8	GYG2 GYG1	1.70e-04	10	37	2	IPR002495
Domain	Glyco_transf_8	GYG2 GYG1	1.70e-04	10	37	2	PF01501
Domain	MAD_homology1_Dwarfin-type	SMAD2 SMAD3	2.49e-04	12	37	2	IPR003619
Domain	DWA	SMAD2 SMAD3	2.49e-04	12	37	2	SM00523
Domain	MH1	SMAD2 SMAD3	2.49e-04	12	37	2	PF03165
Domain	SMAD_dom-like	SMAD2 SMAD3	4.50e-04	16	37	2	IPR017855
Domain	-	SMAD2 SMAD3	4.50e-04	16	37	2	2.60.200.10
Domain	C_TYPE_LECTIN_1	SELE MRC1 VCAN	5.29e-04	80	37	3	PS00615
Domain	Lectin_C	SELE MRC1 VCAN	6.11e-04	84	37	3	PF00059
Domain	CLECT	SELE MRC1 VCAN	6.11e-04	84	37	3	SM00034
Domain	C_TYPE_LECTIN_2	SELE MRC1 VCAN	6.32e-04	85	37	3	PS50041
Domain	C-type_lectin-like	SELE MRC1 VCAN	6.54e-04	86	37	3	IPR001304
Domain	-	SELE MRC1 VCAN	9.28e-04	97	37	3	3.10.100.10
Domain	EGF_Ca-bd_CS	CUBN VCAN NOTCH3	9.28e-04	97	37	3	IPR018097
Domain	EGF_CA	CUBN VCAN NOTCH3	9.85e-04	99	37	3	PS01187
Domain	C-type_lectin-like/link	SELE MRC1 VCAN	9.85e-04	99	37	3	IPR016186
Domain	ASX_HYDROXYL	CUBN VCAN NOTCH3	1.01e-03	100	37	3	PS00010
Domain	EF-hand_5	PLCD4 CAPN3	1.11e-03	25	37	2	PF13202
Domain	EGF_3	SELE CUBN VCAN NOTCH3	1.16e-03	235	37	4	PS50026
Domain	EGF	SELE CUBN VCAN NOTCH3	1.16e-03	235	37	4	SM00181
Domain	EGF-type_Asp/Asn_hydroxyl_site	CUBN VCAN NOTCH3	1.20e-03	106	37	3	IPR000152
Domain	CTDL_fold	SELE MRC1 VCAN	1.23e-03	107	37	3	IPR016187
Domain	EGF-like_dom	SELE CUBN VCAN NOTCH3	1.44e-03	249	37	4	IPR000742
Domain	EGF_1	SELE CUBN VCAN NOTCH3	1.57e-03	255	37	4	PS00022
Domain	EGF-like_CS	SELE CUBN VCAN NOTCH3	1.71e-03	261	37	4	IPR013032
Domain	EGF_CA	CUBN VCAN NOTCH3	1.80e-03	122	37	3	SM00179
Domain	EGF_2	SELE CUBN VCAN NOTCH3	1.81e-03	265	37	4	PS01186
Domain	EGF-like_Ca-bd_dom	CUBN VCAN NOTCH3	1.88e-03	124	37	3	IPR001881
Domain	SMAD_FHA_domain	SMAD2 SMAD3	4.76e-03	52	37	2	IPR008984
Domain	F-box	FBXO16 FBXL13	7.79e-03	67	37	2	PF00646
Domain	FBOX	FBXO16 FBXL13	8.95e-03	72	37	2	PS50181
Domain	F-box_dom	FBXO16 FBXL13	9.68e-03	75	37	2	IPR001810
Domain	-	GYG2 GYG1	1.12e-02	81	37	2	3.90.550.10
Pathway	REACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION	OPN1MW2 OPN1LW OPN1MW3	5.35e-07	8	31	3	MM14880
Pathway	REACTOME_OPSINS	OPN1MW2 OPN1LW OPN1MW3	1.14e-06	10	31	3	MM15063
Pathway	WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING	RPTOR SMAD2 SMAD3	6.55e-05	36	31	3	M39569
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOGEN_BIOSYNTHESIS	GYG2 GYG1	6.98e-05	6	31	2	M47620
Pathway	REACTOME_SIGNALING_BY_NODAL	SMAD2 SMAD3	6.98e-05	6	31	2	MM14517
Pathway	WP_NEOVASCULARIZATION_PROCESSES	NOTCH3 SMAD2 SMAD3	7.11e-05	37	31	3	M39506
Pathway	WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA	RPTOR SMAD2 SMAD3	9.00e-05	40	31	3	M48337
Pathway	REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER	SMAD2 SMAD3	9.76e-05	7	31	2	M29623
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES	SMAD2 SMAD3	9.76e-05	7	31	2	MM15661
Pathway	REACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION	OPN1LW OPN1MW	9.76e-05	7	31	2	M27157
Pathway	REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER	SMAD2 SMAD3	1.30e-04	8	31	2	M27246
Pathway	KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY	SMAD2 SMAD3	1.30e-04	8	31	2	M47415
Pathway	KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY	SMAD2 SMAD3	1.30e-04	8	31	2	M47849
Pathway	KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY	SMAD2 SMAD3	1.30e-04	8	31	2	M47846
Pathway	REACTOME_OPSINS	OPN1LW OPN1MW	1.67e-04	9	31	2	M6285
Pathway	REACTOME_DISEASES_OF_METABOLISM	GYG2 CUBN GYG1 VCAN NOTCH3	1.96e-04	250	31	5	M27554
Pathway	WP_TGFB_SMAD_SIGNALING	SMAD2 SMAD3	3.05e-04	12	31	2	M48091
Pathway	REACTOME_RETINOID_CYCLE_DISEASE_EVENTS	OPN1LW OPN1MW	3.60e-04	13	31	2	M29612
Pathway	WP_DISORDERS_OF_GALACTOSE_METABOLISM	GYG2 GYG1	3.60e-04	13	31	2	M45545
Pathway	REACTOME_GLYCOGEN_SYNTHESIS	GYG2 GYG1	4.19e-04	14	31	2	M27247
Pathway	REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS	GYG2 GYG1	4.19e-04	14	31	2	M19193
Pathway	REACTOME_FORMATION_OF_AXIAL_MESODERM	SMAD2 SMAD3	4.19e-04	14	31	2	M46441
Pathway	REACTOME_SIGNALING_BY_ACTIVIN	SMAD2 SMAD3	4.83e-04	15	31	2	MM14593
Pathway	PID_SMAD2_3PATHWAY	SMAD2 SMAD3	5.51e-04	16	31	2	M228
Pathway	REACTOME_GLYCOGEN_STORAGE_DISEASES	GYG2 GYG1	5.51e-04	16	31	2	M27236
Pathway	REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING	SMAD2 SMAD3	5.51e-04	16	31	2	MM14873
Pathway	WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY	SMAD2 SMAD3 CAPN3	5.62e-04	74	31	3	M48080
Pathway	REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION	SMAD2 SMAD3	6.24e-04	17	31	2	M45017
Pathway	WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING	SMAD2 SMAD3	6.24e-04	17	31	2	M39686
Pathway	BIOCARTA_TGFB_PATHWAY	SMAD2 SMAD3	6.24e-04	17	31	2	MM1509
Pathway	REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM	SMAD2 SMAD3	6.24e-04	17	31	2	M48030
Pathway	REACTOME_SIGNALING_BY_ACTIVIN	SMAD2 SMAD3	6.24e-04	17	31	2	M26965
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES	SMAD2 SMAD3	6.24e-04	17	31	2	M27946
Pathway	REACTOME_SENSORY_PERCEPTION	OR10A3 OPN1MW2 OPN1LW OPN1MW3	7.57e-04	190	31	4	MM15687
Pathway	WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION	SMAD2 SMAD3	7.82e-04	19	31	2	M39370
Pathway	BIOCARTA_TGFB_PATHWAY	SMAD2 SMAD3	7.82e-04	19	31	2	M18933
Pathway	WP_HYPOXIADEPENDENT_PROLIFERATION_OF_MYOBLASTS	SMAD2 SMAD3	7.82e-04	19	31	2	MM15811
Pathway	WP_PANCREATIC_ADENOCARCINOMA_PATHWAY	TIAM1 SMAD2 SMAD3	9.62e-04	89	31	3	M39732
Pathway	WP_PROGERIAASSOCIATED_LIPODYSTROPHY	SMAD2 SMAD3	1.05e-03	22	31	2	M42534
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION	SMAD2 SMAD3	1.05e-03	22	31	2	MM15656
Pathway	REACTOME_VISUAL_PHOTOTRANSDUCTION	OPN1MW2 OPN1LW OPN1MW3	1.06e-03	92	31	3	MM14881
Pathway	REACTOME_SIGNALING_BY_NODAL	SMAD2 SMAD3	1.15e-03	23	31	2	M511
Pathway	REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY	SMAD2 SMAD3	1.25e-03	24	31	2	MM14877
Pathway	REACTOME_GLYCOGEN_METABOLISM	GYG2 GYG1	1.36e-03	25	31	2	M27857
Pathway	WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE	SMAD2 SMAD3	1.36e-03	25	31	2	M39713
Pathway	REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION	SMAD2 SMAD3	1.47e-03	26	31	2	MM14878
Pathway	REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING	SMAD2 SMAD3	1.47e-03	26	31	2	M628
Pathway	WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER	RPTOR SMAD2 SMAD3	1.77e-03	110	31	3	M48043
Pathway	WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS	SMAD2 SMAD3	1.83e-03	29	31	2	M39516
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES	SMAD2 SMAD3	1.96e-03	30	31	2	M27941
Pathway	REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY	SMAD2 SMAD3	2.09e-03	31	31	2	M669
Pathway	WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING	SMAD2 SMAD3	2.09e-03	31	31	2	MM15818
Pathway	REACTOME_DISEASES_OF_CARBOHYDRATE_METABOLISM	GYG2 GYG1	2.51e-03	34	31	2	M27546
Pathway	REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION	SMAD2 SMAD3	2.81e-03	36	31	2	M633
Pathway	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS	SMAD2 SMAD3	3.13e-03	38	31	2	MM14874
Pathway	WP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION	GYG2 GYG1	3.47e-03	40	31	2	M39595
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER	SMAD2 SMAD3	3.64e-03	41	31	2	MM14876
Pathway	WP_ENDODERM_DIFFERENTIATION	AHDC1 SMAD2 SMAD3	3.73e-03	143	31	3	M39591
Pathway	WP_MESODERMAL_COMMITMENT_PATHWAY	AHDC1 SMAD2 SMAD3	4.51e-03	153	31	3	M39546
Pathway	WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY	SMAD2 SMAD3	4.56e-03	46	31	2	M39828
Pathway	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS	SMAD2 SMAD3	4.76e-03	47	31	2	M646
Pathway	WP_GPCRS_ODORANT	OPN1MW2 OPN1LW OPN1MW3	4.85e-03	157	31	3	MM15872
Pathway	WP_INTEGRATED_CANCER_PATHWAY	SMAD2 SMAD3	4.96e-03	48	31	2	M39628
Pathway	WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER	NOTCH3 SMAD2 SMAD3	5.20e-03	161	31	3	M39770
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER	SMAD2 SMAD3	5.58e-03	51	31	2	M665
Pathway	WP_TGFBETA_SIGNALING_PATHWAY	SMAD2 SMAD3	6.01e-03	53	31	2	MM15880
Pathway	PID_TGFBR_PATHWAY	SMAD2 SMAD3	6.24e-03	54	31	2	M286
Pathway	WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER	SMAD2 SMAD3	6.24e-03	54	31	2	M42568
Pubmed	Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy.	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	1.21e-12	4	38	4	29386880
Pubmed	Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	6.05e-12	5	38	4	2937147
Pubmed	Molecular determinants of human red/green color discrimination.	OPN1MW2 OPN1LW OPN1MW	1.20e-09	3	38	3	8185948
Pubmed	X-linked cone dystrophy caused by mutation of the red and green cone opsins.	OPN1MW2 OPN1LW OPN1MW	1.20e-09	3	38	3	20579627
Pubmed	Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	38410159
Pubmed	Chloride-dependent spectral tuning mechanism of L-group cone visual pigments.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	23350963
Pubmed	Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	20471354
Pubmed	Multiple hypothalamic cell populations encoding distinct visual information.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	21224225
Pubmed	Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	36216501
Pubmed	Spectral tuning of a circadian photopigment in a subterranean 'blind' mammal (Spalax ehrenbergi).	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	10567724
Pubmed	Extensive cone-dependent spectral opponency within a discrete zone of the lateral geniculate nucleus supporting mouse color vision.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	34111401
Pubmed	Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	14500905
Pubmed	Gene-based Therapy in a Mouse Model of Blue Cone Monochromacy.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	28751656
Pubmed	Rescue of M-cone Function in Aged Opn1mw-/- Mice, a Model for Late-Stage Blue Cone Monochromacy.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	31469404
Pubmed	The molecular genetics and evolution of red and green color vision in vertebrates.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	11545071
Pubmed	Mechanisms of spectral tuning in the mouse green cone pigment.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	9238068
Pubmed	Emergence of novel color vision in mice engineered to express a human cone photopigment.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	17379811
Pubmed	Co-expression of murine opsins facilitates identifying the site of cone adaptation.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	12511072
Pubmed	The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development.	OPN1MW2 OPN1LW OPN1MW3	1.20e-09	3	38	3	7958444
Pubmed	Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd1 PDE6β mice.	OPN1MW2 OPN1LW OPN1MW3	4.81e-09	4	38	3	31461375
Pubmed	Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments.	OPN1MW2 OPN1LW OPN1MW3	4.81e-09	4	38	3	8088841
Pubmed	Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity.	OPN1MW2 OPN1LW OPN1MW3	4.81e-09	4	38	3	28103478
Pubmed	Molecular biology of the visual pigments.	OPN1MW2 OPN1LW OPN1MW	4.81e-09	4	38	3	3303660
Pubmed	Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight.	OPN1MW2 OPN1LW OPN1MW3	4.81e-09	4	38	3	31846668
Pubmed	Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn.	OPN1MW2 OPN1LW OPN1MW3	4.81e-09	4	38	3	26438865
Pubmed	Light/dark translocation of alphatransducin in mouse photoreceptor cells expressing G90D mutant opsin.	OPN1MW2 OPN1LW OPN1MW3	4.81e-09	4	38	3	17249565
Pubmed	Structural and functional rescue of cones carrying the most common cone opsin C203R missense mutation.	OPN1MW2 OPN1LW OPN1MW3	4.81e-09	4	38	3	38060327
Pubmed	Contribution of M-opsin-based color vision to refractive development in mice.	OPN1MW2 OPN1LW OPN1MW3	4.81e-09	4	38	3	34126082
Pubmed	Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.	OPN1MW2 OPN1LW OPN1MW3	4.81e-09	4	38	3	16567464
Pubmed	S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant.	OPN1MW2 OPN1LW OPN1MW3	4.81e-09	4	38	3	24801621
Pubmed	Melanopsin Contributions to the Representation of Images in the Early Visual System.	OPN1MW2 OPN1LW OPN1MW3	4.81e-09	4	38	3	28528909
Pubmed	Melanopsin-driven light adaptation in mouse vision.	OPN1MW2 OPN1LW OPN1MW3	4.81e-09	4	38	3	25308073
Pubmed	Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.	OPN1MW2 OPN1LW OPN1MW3	1.20e-08	5	38	3	36631163
Pubmed	Using Silent Substitution to Track the Mesopic Transition From Rod- to Cone-Based Vision in Mice.	OPN1MW2 OPN1LW OPN1MW3	1.20e-08	5	38	3	26818794
Pubmed	A common integration locus in type B retrovirus-induced thymic lymphomas.	OPN1MW2 OPN1LW OPN1MW3	1.20e-08	5	38	3	1333116
Pubmed	The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways.	NOTCH3 SMAD2 SMAD3	1.20e-08	5	38	3	28747678
Pubmed	A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus.	OPN1MW2 OPN1LW OPN1MW3	1.20e-08	5	38	3	22090509
Pubmed	Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.	OPN1MW2 OPN1LW OPN1MW3	1.20e-08	5	38	3	10723722
Pubmed	Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.	OPN1MW2 OPN1LW OPN1MW3	1.20e-08	5	38	3	27033727
Pubmed	Melanopsin-based brightness discrimination in mice and humans.	OPN1MW2 OPN1LW OPN1MW3	1.20e-08	5	38	3	22633808
Pubmed	The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.	OPN1MW2 OPN1LW OPN1MW3	1.20e-08	5	38	3	11055434
Pubmed	Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and COUP-TFII.	OPN1MW2 OPN1LW OPN1MW3	1.20e-08	5	38	3	24058409
Pubmed	Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning.	OPN1MW2 OPN1LW OPN1MW3	1.20e-08	5	38	3	34099749
Pubmed	Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina.	OPN1MW2 OPN1LW OPN1MW3 NOTCH3	1.78e-08	26	38	4	19828801
Pubmed	The complex interplay between ERK1/2, TGFβ/Smad, and Jagged/Notch signaling pathways in the regulation of epithelial-mesenchymal transition in retinal pigment epithelium cells.	NOTCH3 SMAD2 SMAD3	2.40e-08	6	38	3	24788939
Pubmed	Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.	OPN1MW2 OPN1LW OPN1MW3	2.40e-08	6	38	3	23288843
Pubmed	Reduced levels of dystrophin associated proteins in the brains of mice deficient for Dp71.	OPN1MW2 OPN1LW OPN1MW3	2.40e-08	6	38	3	8872469
Pubmed	A thyroid hormone receptor that is required for the development of green cone photoreceptors.	OPN1MW2 OPN1LW OPN1MW3	2.40e-08	6	38	3	11138006
Pubmed	Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase.	OPN1MW2 OPN1LW OPN1MW3	2.40e-08	6	38	3	10395695
Pubmed	Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.	OPN1MW2 OPN1LW OPN1MW3	2.40e-08	6	38	3	17436273
Pubmed	Telomere-related markers for the pseudoautosomal region of the mouse genome.	OPN1MW2 OPN1LW OPN1MW3	2.40e-08	6	38	3	1549575
Pubmed	Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice.	OPN1MW2 OPN1LW OPN1MW3	4.20e-08	7	38	3	18974269
Pubmed	Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	4.20e-08	7	38	3	8001979
Pubmed	NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina.	OPN1MW2 OPN1LW OPN1MW3	4.20e-08	7	38	3	18199774
Pubmed	Mapping of the murine tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes.	OPN1MW2 OPN1LW OPN1MW3	4.20e-08	7	38	3	9880679
Pubmed	Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.	OPN1MW2 OPN1LW OPN1MW3	4.20e-08	7	38	3	8378320
Pubmed	Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina.	OPN1MW2 OPN1LW OPN1MW3	4.20e-08	7	38	3	30799247
Pubmed	Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta.	OPN1MW2 OPN1LW OPN1MW3	4.20e-08	7	38	3	16574740
Pubmed	Rods progressively escape saturation to drive visual responses in daylight conditions.	OPN1MW2 OPN1LW OPN1MW3	4.20e-08	7	38	3	29180667
Pubmed	Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.	OPN1MW2 OPN1LW OPN1MW3	4.20e-08	7	38	3	19332056
Pubmed	Localization of the mdx mutation within the mouse dystrophin gene.	OPN1MW2 OPN1LW OPN1MW3	6.71e-08	8	38	3	2903046
Pubmed	Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation.	VCAN SMAD2 SMAD3	6.71e-08	8	38	3	21041365
Pubmed	Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes.	OPN1MW2 OPN1LW OPN1MW3	6.71e-08	8	38	3	1572654
Pubmed	Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.	OPN1MW2 OPN1LW OPN1MW3	6.71e-08	8	38	3	21813673
Pubmed	X-chromosome gene order in different Mus species crosses.	OPN1MW2 OPN1LW OPN1MW3	6.71e-08	8	38	3	3416629
Pubmed	The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis.	OPN1MW2 OPN1LW OPN1MW3	6.71e-08	8	38	3	12651948
Pubmed	Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation.	OPN1MW2 OPN1LW OPN1MW3	6.71e-08	8	38	3	31163126
Pubmed	Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors.	OPN1MW2 OPN1LW OPN1MW3	6.71e-08	8	38	3	20203194
Pubmed	Tubby is required for trafficking G protein-coupled receptors to neuronal cilia.	OPN1MW2 OPN1LW OPN1MW3	6.71e-08	8	38	3	23351594
Pubmed	A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3).	OPN1MW2 OPN1LW OPN1MW3	6.71e-08	8	38	3	10725384
Pubmed	Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina.	OPN1MW2 OPN1LW OPN1MW3	6.71e-08	8	38	3	16043864
Pubmed	Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates retinitis pigmentosa and enhanced S-cone syndrome models.	OPN1MW2 OPN1LW OPN1MW3	6.71e-08	8	38	3	33007388
Pubmed	Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3).	OPN1LW SMAD2 SMAD3	6.71e-08	8	38	3	14691252
Pubmed	Linkage of amelogenin (Amel) to the distal portion of the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	6.71e-08	8	38	3	1675194
Pubmed	Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.	OPN1MW2 OPN1LW OPN1MW3	1.01e-07	9	38	3	14742273
Pubmed	Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL.	OPN1MW2 OPN1LW OPN1MW3	1.01e-07	9	38	3	25296752
Pubmed	Comparative mapping of the actin-binding protein 280 genes in human and mouse.	OPN1MW2 OPN1LW OPN1MW3	1.01e-07	9	38	3	8088838
Pubmed	ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse.	OPN1MW2 OPN1LW OPN1MW3	1.01e-07	9	38	3	21850176
Pubmed	Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network.	OPN1MW2 OPN1LW OPN1MW3	1.01e-07	9	38	3	28370415
Pubmed	IFT20 is required for opsin trafficking and photoreceptor outer segment development.	OPN1MW2 OPN1LW OPN1MW3	1.01e-07	9	38	3	21307337
Pubmed	Multilocus molecular mapping of the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	1.01e-07	9	38	3	2906327
Pubmed	A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction.	OPN1MW2 OPN1LW OPN1MW3	1.01e-07	9	38	3	27669145
Pubmed	Close linkage of the murine locus bare patches to the X-linked visual pigment gene: implications for mapping human X-linked dominant chondrodysplasia punctata.	OPN1MW2 OPN1LW OPN1MW3	1.01e-07	9	38	3	1973136
Pubmed	Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development.	OPN1MW2 OPN1LW OPN1MW3	1.01e-07	9	38	3	12407160
Pubmed	mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia.	OPN1MW2 OPN1LW OPN1MW3 RPTOR	1.08e-07	40	38	4	34677125
Pubmed	Mapping of ornithine aminotransferase gene sequences to mouse chromosomes 7, X, and 3.	OPN1MW2 OPN1LW OPN1MW3	1.44e-07	10	38	3	1349842
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	OPN1MW2 OPN1LW OPN1MW	1.44e-07	10	38	3	8857542
Pubmed	Linkage of a gene for neural cell adhesion molecule, L1 (CamL1) to the Rsvp region of the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	1.44e-07	10	38	3	1964443
Pubmed	Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye.	OPN1MW2 OPN1LW OPN1MW3	1.44e-07	10	38	3	21148184
Pubmed	Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.	OPN1MW2 OPN1LW OPN1MW3	1.44e-07	10	38	3	31949211
Pubmed	Comparative mapping on the mouse and human X chromosomes of a human cDNA clone encoding the vasopressin renal-type receptor (AVP2R).	OPN1MW2 OPN1LW OPN1MW3	1.44e-07	10	38	3	8449515
Pubmed	The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.	OPN1MW2 OPN1LW OPN1MW3	1.44e-07	10	38	3	32236127
Pubmed	Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a region of the mouse X chromosome homologous to human Xq28.	OPN1MW2 OPN1LW OPN1MW3	1.44e-07	10	38	3	1684949
Pubmed	Mapping of the phosphorylase kinase alpha subunit gene on the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	1.44e-07	10	38	3	1973380
Pubmed	mTORC1 accelerates retinal development via the immunoproteasome.	OPN1MW2 OPN1LW OPN1MW3 RPTOR	1.91e-07	46	38	4	29950673
Pubmed	Versican facilitates chondrocyte differentiation and regulates joint morphogenesis.	VCAN SMAD2 SMAD3	1.97e-07	11	38	3	20404343
Pubmed	Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP genes on the human and mouse X chromosomes.	OPN1MW2 OPN1LW OPN1MW3	1.97e-07	11	38	3	1572636
Pubmed	Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice.	OPN1MW2 OPN1LW OPN1MW3	1.97e-07	11	38	3	24421398
Pubmed	Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome.	OPN1MW2 OPN1LW OPN1MW3	2.63e-07	12	38	3	1679744
Pubmed	The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors.	OPN1MW2 OPN1LW OPN1MW3	2.63e-07	12	38	3	19812316
Interaction	NOTCH4 interactions	NOTCH3 SMAD2 SMAD3	5.72e-06	21	34	3	int:NOTCH4
Interaction	PIAS3 interactions	OPN1LW MORC3 SMAD2 SMAD3	1.93e-05	95	34	4	int:PIAS3
Interaction	TOB1 interactions	FBXL13 SMAD2 SMAD3	5.54e-05	44	34	3	int:TOB1
Interaction	CYP11A1 interactions	SMAD2 SMAD3	9.87e-05	9	34	2	int:CYP11A1
Cytoband	Ensembl 112 genes in cytogenetic band chrXq28	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	2.94e-05	213	38	4	chrXq28
Cytoband	Xq28	OPN1MW2 OPN1LW OPN1MW	4.23e-04	176	38	3	Xq28
Cytoband	Ensembl 112 genes in cytogenetic band chr1p35	CSMD2 AHDC1	5.79e-03	137	38	2	chr1p35
GeneFamily	Opsin receptors	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	2.64e-09	11	32	4	215
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELE CFHR5 CSMD1 CSMD2 VCAN	4.91e-08	57	32	5	1179
GeneFamily	SMAD family	SMAD2 SMAD3	8.44e-05	8	32	2	750
GeneFamily	Glycosyltransferase family 8	GYG2 GYG1	1.08e-04	9	32	2	436
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELE VCAN	2.38e-03	41	32	2	1298
ToppCell	BAL-Severe-cDC_4\|Severe / Compartment, Disease Groups and Clusters	MRC1 CSMD1 TIAM1 VCAN	7.90e-06	158	36	4	73f66689ef59f71b14cb7141ca5951cc47fe57c1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CUBN CSMD1 CSMD2 DNAH9	9.83e-06	167	36	4	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELE PLCD4 AHDC1 NOTCH3	1.24e-05	177	36	4	7c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELE PLCD4 AHDC1 NOTCH3	1.24e-05	177	36	4	e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCell	droplet-Limb_Muscle-nan-21m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLCD4 VGLL2 GYG1 CAPN3	1.32e-05	180	36	4	cea62fc006d68c3815c88bf17ec2617d7e41c3d2
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CSMD1 CSMD2 NPAS4 NOTCH3	2.00e-05	200	36	4	9169a9ec8e9ab95d90a64c5a19ac666a5cf82313
Drug	AC1L1CHL	SELE OPN1LW MRC1 OPN1MW	1.58e-05	96	36	4	CID000001902
Drug	Mcat	VGLL2 SMAD2 SMAD3	2.29e-05	35	36	3	CID003080785
Drug	Phpc-1,2	OPN1LW OPN1MW	2.42e-05	5	36	2	CID000173570
Drug	14-fluororetinal	OPN1LW OPN1MW	2.42e-05	5	36	2	CID006438634
Drug	10,20-methanoretinal	OPN1LW OPN1MW	2.42e-05	5	36	2	CID006438558
Drug	trans-retinoyl chloromethane	OPN1LW OPN1MW	2.42e-05	5	36	2	CID006439860
Drug	9,11-dcfr	OPN1LW OPN1MW	2.42e-05	5	36	2	CID006443659
Drug	maltos	SELE MRC1 TMPRSS15 GYG1 VCAN CAPN3	3.20e-05	393	36	6	CID000000294
Drug	3-hydroxyretinal	OPN1LW OPN1MW	3.63e-05	6	36	2	CID000151436
Drug	7,8-Dhr	OPN1LW OPN1MW	3.63e-05	6	36	2	CID006443426
Drug	AC1NTD7Z	OPN1LW OPN1MW	3.63e-05	6	36	2	CID005378594
Drug	5,6-epoxy-3-dehydroretinal	OPN1LW OPN1MW	3.63e-05	6	36	2	CID006449988
Drug	4-n-butylaniline	OPN1LW OPN1MW	5.08e-05	7	36	2	CID000007694
Drug	M 41	GYG2 GYG1	6.77e-05	8	36	2	CID006435659
Drug	AC1NP3ER	SELE VCAN	8.69e-05	9	36	2	CID005123418
Drug	Nexus	GYG2 OPN1MW NPAS4 VCAN	9.52e-05	152	36	4	CID000098527
Drug	LY2109761	SMAD2 SMAD3	1.09e-04	10	36	2	ctd:C530108
Drug	protocatechualdehyde	SMAD2 SMAD3	1.09e-04	10	36	2	ctd:C005581
Drug	CP094	TMPRSS15 CUBN SMAD2 SMAD3	1.31e-04	165	36	4	CID000086322
Drug	mannose-1-phosphate	GYG2 TIAM1 GYG1 VCAN	1.31e-04	165	36	4	CID000000466
Drug	3-methylglutaric acid	CUBN ECHS1	1.32e-04	11	36	2	CID000012284
Drug	Wen-pi-tang-Hab-Wu-ling-san	SMAD2 SMAD3	1.32e-04	11	36	2	ctd:C521629
Drug	Photoproduct	OPN1LW OPN1MW	1.32e-04	11	36	2	CID000500521
Drug	retinal oxime	OPN1LW OPN1MW	1.32e-04	11	36	2	CID009577279
Drug	AC1L18QD	SELE OPN1LW PLCD4 OPN1MW VCAN	1.51e-04	325	36	5	CID000000213
Drug	A1-E	SELE OPN1LW OPN1MW	1.55e-04	66	36	3	CID005326966
Drug	galangin	SELE SMAD2 SMAD3	1.70e-04	68	36	3	ctd:C037032
Drug	AC1L28XQ	OPN1LW OPN1MW	2.19e-04	14	36	2	CID000068054
Drug	AC1NQA65	CUBN ECHS1	2.19e-04	14	36	2	CID005172180
Drug	Phloroglucinol	SMAD2 SMAD3	2.19e-04	14	36	2	ctd:D010696
Drug	Cyclosporin A [59865-13-3]; Down 200; 3.4uM; HL60; HT_HG-U133A	APOBEC3B VCAN SMAD3 CAPN3	2.38e-04	193	36	4	1331_DN
Drug	Biotin	SELE TMPRSS15	2.52e-04	15	36	2	ctd:D001710
Drug	Azathymine, 6 [932-53-6]; Up 200; 31.4uM; HL60; HT_HG-U133A	GYG2 TMPRSS15 CFHR5 SMAD3	2.58e-04	197	36	4	2466_UP
Drug	Phensuximide [86-34-0]; Up 200; 21.2uM; HL60; HT_HG-U133A	GYG2 TMPRSS15 SMAD3 CAPN3	2.63e-04	198	36	4	2960_UP
Drug	Glimepiride [93479-97-1]; Up 200; 8.2uM; MCF7; HT_HG-U133A	GYG2 TMPRSS15 VCAN SMAD3	2.68e-04	199	36	4	4973_UP
Disease	blue cone monochromacy (implicated_via_orthology)	OPN1MW2 OPN1LW OPN1MW3 OPN1MW	2.09e-12	4	37	4	DOID:0050679 (implicated_via_orthology)
Disease	Cone monochromatism	OPN1LW OPN1MW	1.53e-06	2	37	2	C0339537
Disease	BLUE CONE MONOCHROMACY	OPN1LW OPN1MW	1.53e-06	2	37	2	303700
Disease	Cone monochromatism	OPN1LW OPN1MW	1.53e-06	2	37	2	cv:C0339537
Disease	blue cone monochromacy (is_implicated_in)	OPN1LW OPN1MW	1.53e-06	2	37	2	DOID:0050679 (is_implicated_in)
Disease	BORNHOLM EYE DISEASE	OPN1LW OPN1MW	1.53e-06	2	37	2	C3159311
Disease	Achromatopsia incomplete, X-linked	OPN1LW OPN1MW	1.53e-06	2	37	2	C2931753
Disease	Red-green dyschromatopsia	OPN1LW OPN1MW	1.53e-06	2	37	2	cv:C0155016
Disease	coronary aneurysm	CSMD1 CSMD2 ZNF618	1.16e-05	35	37	3	EFO_1000881
Disease	Loeys-Dietz Syndrome	SMAD2 SMAD3	3.20e-05	7	37	2	C2697932
Disease	Familial thoracic aortic aneurysm and aortic dissection	VCAN SMAD2 SMAD3	4.07e-05	53	37	3	C4707243
Disease	phosphatidylcholine 40:6 measurement	CSMD1 DNAH9	2.06e-04	17	37	2	EFO_0010389
Disease	Left Ventricle Remodeling	SMAD2 SMAD3	3.16e-04	21	37	2	C0600520
Disease	Ventricular Remodeling	SMAD2 SMAD3	3.16e-04	21	37	2	C0600519
Disease	pathological myopia	DNAH9 VGLL2 RPTOR	3.67e-04	111	37	3	EFO_0004207
Disease	airway responsiveness measurement	CSMD1 RPTOR	4.15e-04	24	37	2	EFO_0006897
Disease	Lynch syndrome (is_implicated_in)	SMAD2 SMAD3	4.15e-04	24	37	2	DOID:3883 (is_implicated_in)
Disease	Squamous cell carcinoma	TIAM1 APOBEC3B NOTCH3	5.07e-04	124	37	3	C0007137
Disease	Glycogen Storage Disease	GYG2 GYG1	5.26e-04	27	37	2	C0017919
Disease	lumbar disc degeneration	CSMD1 SMAD3	5.67e-04	28	37	2	EFO_0004994
Disease	Cone-Rod Dystrophy 2	OPN1LW OPN1MW	6.08e-04	29	37	2	C3489532
Disease	Strabismus	CSMD1 ZNF618	6.08e-04	29	37	2	HP_0000486
Disease	colorectal adenoma	FBXL13 CSMD2	7.88e-04	33	37	2	EFO_0005406
Disease	endometrial cancer (is_marker_for)	SMAD2 SMAD3	8.87e-04	35	37	2	DOID:1380 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FPDFYPNSLNCTWTI	CSMD1	946	Q96PZ7
TCQHGINRNWNYPFP	CSMD1	2126	Q96PZ7
QSYPGSYPQFQTCSW	CSMD2	2371	Q7Z408
QYENWRPNQPDSFFS	VCAN	3246	P13611
DTFVYRQGCPFQPWD	APOBEC3B	346	Q9UH17
PENCRQFAGASQWPF	AHDC1	1096	Q5TGY3
WGPYTFFACFAAANP	OPN1LW	281	P04000
WGPYAFFACFAAANP	OPN1MW3	281	P0DN78
WGPYAFFACFAAANP	OPN1MW2	281	P0DN77
TWVFSFPFCGPNEIN	OR10A3	161	P58181
NFPNSYPNLAFCVWI	TMPRSS15	541	P98073
CPAWRPFASGANFEY	ECHS1	21	P30084
EKWYCSNNPDPQFRN	MORC3	431	Q14149
NTYNCQCPPEWTGQF	NOTCH3	256	Q9UM47
GFVECFQNPGSFPWN	SELE	251	P16581
FQNPGSFPWNTTCTF	SELE	256	P16581
VFPNRSPWCQNPYVS	LMNTD1	326	Q8N9Z9
WGPYAFFACFAAANP	OPN1MW	281	P04001
WPDCFNSGVFVFQPS	GYG2	161	O15488
YWAGNPVFTAFCAPL	NPAS4	181	Q8IUM7
RFPANYPNNQNCSWI	CUBN	1636	O60494
PGWPDCFNSGVFVYQ	GYG1	126	P46976
QEYNTNDPPRWFGYD	FBXL13	686	Q8NEE6
SVQCYQFGWSPNFPT	CFHR5	186	Q9BXR6
KFGPQGWNRSYPFNT	DNAH9	4066	Q9NYC9
FNWYINFSPTPFEQG	FBXO16	136	Q8IX29
GCRNFPDTFWTNPQY	CAPN3	446	P20807
SNLSAPAGGYFWCNF	ERVFC1	321	P60507
SGFWNDINCGYPNAF	MRC1	906	P22897
NNGFNPYWGQTLCFR	PLCD4	676	Q9BRC7
NVNGTVPNEYCWPFS	SAMD8	391	Q96LT4
NFNPPTRRNWESNYF	ARHGAP5	1246	Q13017
WNSFCNSDDPYNPLN	PPP1R15B	556	Q5SWA1
QTGFCDWSARYFAQP	RPTOR	956	Q8N122
FNLQWFFNDSCAPPT	TM4SF20	141	Q53R12
PLFQATPDLFQYWSC	ZNF618	881	Q5T7W0
FPASFWNSAYQAPVP	VGLL2	141	Q8N8G2
HEYFTPSWFCLPNNQ	TIAM1	761	Q13009
FVQSPNCNQRYGWHP	SMAD2	356	Q15796
QSPNCNQRYGWHPAT	SMAD3	316	P84022