Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent activity

ABCB7 ATP7B LONP2 MYO10 EIF4A3 ABCC11 DDX51 ATP13A2 DHX30 SWSAP1 DNAH1 MDN1 SHOC1 DYNC1H1 VCP ATP6V0A2

5.56e-0561416616GO:0140657
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCB7 ATP7B LONP2 EIF4A3 ABCC11 DDX51 ATP13A2 DHX30 SWSAP1 MDN1 SHOC1 DYNC1H1 VCP

8.43e-0544116613GO:0016887
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

NUGGC ABCB7 ATP7B LONP2 EIF4A3 ABCC11 DDX51 ATP13A2 DHX30 SWSAP1 MDN1 SHOC1 RASEF GNAQ GNAT2 DYNC1H1 VCP

2.59e-0477516617GO:0017111
GeneOntologyMolecularFunctionBAT3 complex binding

USP13 VCP

4.08e-0441662GO:1904288
GeneOntologyMolecularFunctioncadherin binding

CDH26 DOCK9 CDH23 EVPL YWHAB CLIC1 PI4KA DCHS1 PKM TMPO

5.59e-0433916610GO:0045296
GeneOntologyMolecularFunctionpyrophosphatase activity

NUGGC ABCB7 ATP7B LONP2 EIF4A3 ABCC11 DDX51 ATP13A2 DHX30 SWSAP1 MDN1 SHOC1 RASEF GNAQ GNAT2 DYNC1H1 VCP

6.39e-0483916617GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

NUGGC ABCB7 ATP7B LONP2 EIF4A3 ABCC11 DDX51 ATP13A2 DHX30 SWSAP1 MDN1 SHOC1 RASEF GNAQ GNAT2 DYNC1H1 VCP

6.48e-0484016617GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

NUGGC ABCB7 ATP7B LONP2 EIF4A3 ABCC11 DDX51 ATP13A2 DHX30 SWSAP1 MDN1 SHOC1 RASEF GNAQ GNAT2 DYNC1H1 VCP

6.48e-0484016617GO:0016818
GeneOntologyCellularComponentmuscle tendon junction

NEURL2 ITGA7 HMCN1

1.00e-0561683GO:0005927
GeneOntologyCellularComponentmulti-pass translocon complex

NOMO1 NOMO2 NOMO3

4.13e-0591683GO:0160064
GeneOntologyCellularComponentER membrane insertion complex

NOMO1 NOMO2 NOMO3

1.74e-04141683GO:0072379
GeneOntologyCellularComponentnuclear envelope

ROGDI NUP210L APP RRM1 DNAJC2 LPIN1 YEATS4 NUP155 CLIC1 HPN TMPO GNAQ QSOX2 DYNC1H1

1.79e-0456016814GO:0005635
GeneOntologyCellularComponentendoplasmic reticulum exit site

CTAGE6 CTAGE8 CTAGE15 CTAGE4

3.55e-04421684GO:0070971
DomainDUF2012

NOMO1 NOMO2 NOMO3

2.50e-0641613PF09430
DomainDUF2012

NOMO1 NOMO2 NOMO3

2.50e-0641613IPR019008
DomainCarb-bd-like_fold

NOMO1 NOMO2 NOMO3

3.41e-0581613IPR013784
DomainCarboxyPept_regulatory_dom

NOMO1 NOMO2 NOMO3

1.69e-04131613IPR014766
DomainOLF

ADGRL1 OLFM3 OLFM1

1.69e-04131613PF02191
DomainOLF

ADGRL1 OLFM3 OLFM1

1.69e-04131613PS51132
Domain-

NOMO1 NOMO2 NOMO3

1.69e-041316132.60.40.1120
DomainOlfac-like_dom

ADGRL1 OLFM3 OLFM1

1.69e-04131613IPR003112
DomainOLF

ADGRL1 OLFM3 OLFM1

1.69e-04131613SM00284
DomainATPase_dyneun-rel_AAA

DNAH1 MDN1 DYNC1H1

2.13e-04141613IPR011704
DomainAAA_5

DNAH1 MDN1 DYNC1H1

2.13e-04141613PF07728
DomainNoelin-1

OLFM3 OLFM1

2.20e-0431612PF12308
DomainNoelin_dom

OLFM3 OLFM1

2.20e-0431612IPR022082
Domain-

NUGGC ABCB7 LONP2 EIF4A3 ABCC11 DDX51 DHX30 SWSAP1 DNAH1 TRANK1 MDN1 RASEF GNAQ COASY GNAT2 DYNC1H1 VCP

2.50e-04746161173.40.50.300
DomainCadherin_CS

CDH26 PCDHGB3 CDH23 PCDHA6 DCHS1 PCDH9

3.64e-041091616IPR020894
DomainP-loop_NTPase

NUGGC ABCB7 LONP2 MYO10 EIF4A3 ABCC11 DDX51 DHX30 SWSAP1 DNAH1 TRANK1 MDN1 RASEF GNAQ COASY GNAT2 DYNC1H1 VCP

3.85e-0484816118IPR027417
DomainCarboxyPept-like_regulatory

NOMO1 NOMO2 NOMO3

3.91e-04171613IPR008969
DomainTF_AF4/FMR2

AFF1 AFF4

4.38e-0441612IPR007797
DomainAF-4

AFF1 AFF4

4.38e-0441612PF05110
DomainCADHERIN_1

CDH26 PCDHGB3 CDH23 PCDHA6 DCHS1 PCDH9

4.42e-041131616PS00232
DomainCadherin

CDH26 PCDHGB3 CDH23 PCDHA6 DCHS1 PCDH9

4.42e-041131616PF00028
DomainCADHERIN_2

CDH26 PCDHGB3 CDH23 PCDHA6 DCHS1 PCDH9

4.63e-041141616PS50268
Domain-

CDH26 PCDHGB3 CDH23 PCDHA6 DCHS1 PCDH9

4.63e-0411416162.60.40.60
DomainCA

CDH26 PCDHGB3 CDH23 PCDHA6 DCHS1 PCDH9

4.85e-041151616SM00112
DomainCadherin-like

CDH26 PCDHGB3 CDH23 PCDHA6 DCHS1 PCDH9

5.08e-041161616IPR015919
DomainCadherin

CDH26 PCDHGB3 CDH23 PCDHA6 DCHS1 PCDH9

5.56e-041181616IPR002126
DomainGPCR_2_latrophilin

ADGRL1 OLFM1

7.26e-0451612IPR003924
DomainHematopoietin_rcpt_Gp130_CS

CSF3R OSMR

1.51e-0371612IPR003529
DomainAAA

ABCB7 LONP2 ABCC11 MDN1 DYNC1H1 VCP

1.57e-031441616SM00382
DomainAAA+_ATPase

ABCB7 LONP2 ABCC11 MDN1 DYNC1H1 VCP

1.57e-031441616IPR003593
DomainFlavodoxin/NO_synth

NDOR1 TYW1

2.00e-0381612IPR008254
DomainFlavdoxin-like

NDOR1 TYW1

2.00e-0381612IPR001094
DomainHEMATOPO_REC_L_F2

CSF3R OSMR

2.00e-0381612PS01353
DomainFLAVODOXIN_LIKE

NDOR1 TYW1

2.00e-0381612PS50902
DomainFlavodoxin_1

NDOR1 TYW1

2.00e-0381612PF00258
DomainMYTH4

MYO10 PLEKHH3

2.55e-0391612PS51016
DomainMyTH4

MYO10 PLEKHH3

2.55e-0391612SM00139
DomainMyTH4_dom

MYO10 PLEKHH3

2.55e-0391612IPR000857
DomainMyTH4

MYO10 PLEKHH3

2.55e-0391612PF00784
DomainMAC_perforin

BRINP3 ASTN1

3.18e-03101612IPR001862
DomainA2M

A2ML1 PZP

3.18e-03101612PF00207
DomainA2M_N_2

A2ML1 PZP

3.18e-03101612IPR011625
DomainA2M_comp

A2ML1 PZP

3.18e-03101612IPR011626
DomainA2M_recep

A2ML1 PZP

3.18e-03101612PF07677
DomainA2M_comp

A2ML1 PZP

3.18e-03101612PF07678
Domain-

NDOR1 TYW1

3.18e-031016123.40.50.360
DomainA2M_N

A2ML1 PZP

3.18e-03101612PF01835
DomainA2M_N

A2ML1 PZP

3.18e-03101612IPR002890
DomainA-macroglobulin_rcpt-bd

A2ML1 PZP

3.18e-03101612IPR009048
DomainALPHA_2_MACROGLOBULIN

A2ML1 PZP

3.18e-03101612PS00477
DomainFlavoprotein-like_dom

NDOR1 TYW1

3.18e-03101612IPR029039
DomainA2M_N_2

A2ML1 PZP

3.18e-03101612PF07703
DomainMacroglobln_a2

A2ML1 PZP

3.18e-03101612IPR001599
DomainFYVE_2

SYTL5 RIMS2

3.86e-03111612PF02318
DomainCYCLIN

CABLES2 CCNH BRF2

4.25e-03381613SM00385
DomainMACPF

BRINP3 ASTN1

4.61e-03121612IPR020864
DomainRABBD

SYTL5 RIMS2

4.61e-03121612PS50916
DomainMACPF

BRINP3 ASTN1

4.61e-03121612SM00457
DomainRab_BD

SYTL5 RIMS2

4.61e-03121612IPR010911
Domain-

CABLES2 CCNH BRF2

4.92e-034016131.10.472.10
DomainCyclin-like

CABLES2 CCNH BRF2

6.03e-03431613IPR013763
DomainDynein_heavy_chain_D4_dom

DNAH1 DYNC1H1

6.28e-03141612IPR024317
DomainDynein_HC_stalk

DNAH1 DYNC1H1

6.28e-03141612IPR024743
DomainDynein_heavy_dom-2

DNAH1 DYNC1H1

6.28e-03141612IPR013602
DomainDHC_N2

DNAH1 DYNC1H1

6.28e-03141612PF08393
DomainMT

DNAH1 DYNC1H1

6.28e-03141612PF12777
DomainAAA_8

DNAH1 DYNC1H1

6.28e-03141612PF12780
DomainuDENN

DENND2A SBF1

6.28e-03141612SM00800
DomainDHC_fam

DNAH1 DYNC1H1

7.20e-03151612IPR026983
DomainuDENN

DENND2A SBF1

7.20e-03151612PF03456
DomainDynein_heavy

DNAH1 DYNC1H1

7.20e-03151612PF03028
DomainDynein_heavy_dom

DNAH1 DYNC1H1

7.20e-03151612IPR004273
DomainGproteinA_insert

GNAQ GNAT2

8.19e-03161612IPR011025
DomainDENN

DENND2A SBF1

8.19e-03161612SM00799
Domain-

GNAQ GNAT2

8.19e-031616121.10.400.10
DomainDENN

DENND2A SBF1

8.19e-03161612PF02141
DomaindDENN

DENND2A SBF1

8.19e-03161612PF03455
DomainG-alpha

GNAQ GNAT2

8.19e-03161612PF00503
DomainUDENN

DENND2A SBF1

8.19e-03161612PS50946
DomainDDENN

DENND2A SBF1

8.19e-03161612PS50947
DomaindDENN

DENND2A SBF1

8.19e-03161612SM00801
DomaindDENN_dom

DENND2A SBF1

8.19e-03161612IPR005112
DomainuDENN_dom

DENND2A SBF1

8.19e-03161612IPR005113
DomainDENN

DENND2A SBF1

8.19e-03161612PS50211
DomainDENN_dom

DENND2A SBF1

8.19e-03161612IPR001194
DomainG_alpha

GNAQ GNAT2

8.19e-03161612SM00275
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ABCB7 ERO1A PSMD2 TSG101 APP ITGA7 RRM1 PIGU YWHAB NOMO1 MSMO1 TMEM9 CLIC1 NOMO2 XPO6 OLFM1 TMPO TYW1 OSMR PLSCR1 QSOX2 VCP ATP6V0A2 TANGO6

4.74e-0912011692435696571
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

CCP110 ELOA NET1 ADRM1 LONP2 RANBP9 CDH23 TSG101 PIGU NXN DIS3 DHX30 NOMO1 CHIC2 EFHC1 YEATS4 NEK5 NANS XPO6 EIF2B4 RIPOR1 PCDH9 DYNC1H1 TP53BP2

2.91e-0813211692427173435
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

KDM5B USP13 NET1 ADRM1 LONP2 MYO10 RANBP9 PSMD2 OAT NXN YWHAB DIS3 STRIP1 COPS7A UBXN2B NUP155 MYCBP KCTD10 TNFAIP1 VCP

1.09e-0710051692019615732
Pubmed

Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.

NOMO1 NOMO2 NOMO3

1.13e-073169336011023
Pubmed

Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep-wake Disturbances in AD Mice.

NDOR1 BACE1 APP

1.13e-073169337536983
Pubmed

Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.

NOMO1 NOMO2 NOMO3

1.13e-073169325576386
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

TNFSF14 ADRM1 NUP210L EIF4A3 DIDO1 PSMD2 YWHAB YEATS4 BRCA2 PI4KA DCHS1 ASTN1 RIPOR1 RIMS2 PCDH9 DYNC1H1 TANGO6

1.85e-077541691735906200
Pubmed

Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.

RANBP9 BACE1 APP

4.49e-074169319251705
Pubmed

Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.

NOMO1 NOMO2 NOMO3

4.49e-074169331833031
Pubmed

A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.

NOMO1 NOMO2 NOMO3

4.49e-07416939267806
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

ELOA ABCB7 RBBP5 RANBP9 PSMD2 DDX51 TSG101 PAF1 NUP155 COG6 NOMO2 EIF2B4 TMPO DYNC1H1

7.00e-075601691435241646
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

ABCB7 ADRM1 EIF4A3 PSMD2 OAT PAF1 RRM1 YWHAB DIS3 DHX30 NOMO1 MDN1 NUP155 NOMO2 PKM SFXN2 TMPO SKAP2 DYNC1H1 NOMO3 VCP

8.96e-0712571692137317656
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

ABCB7 ERO1A OAT CBARP APP PAF1 RRM1 PIGU DNAJC2 DHX30 NOMO1 MDN1 NUP155 SBF1 NOMO2 PI4KA EIF2B4 TMPO ALAS1 TYW1 COASY VCP ATP6V0A2

9.73e-0714871692333957083
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

EIF4A3 RANBP9 PSMD2 YWHAB DHX30 COPS7A CLIC1 AFF4

1.04e-06156169822952844
Pubmed

COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels.

RANBP9 BACE1 APP

1.12e-065169323926111
Pubmed

Evolutionarily conserved regulators of tau identify targets for new therapies.

ATP7B ADRM1 PSMD2 APP NOMO1 NUP155 TMEM9 NOMO2 PKM TMPO NOMO3 VCP ATP6V0A2

1.63e-065161691336610398
Pubmed

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.

PSMD2 NXN YWHAB PER2 PKM TMPO DYNC1H1 VCP

2.45e-06175169825756610
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

WASHC4 EIF4A3 RANBP9 PSMD2 DDX51 RRM1 YWHAB DIS3 DHX30 MDN1 NUP155 SBF1 CLIC1 NANS PI4KA EIF2B4 A2ML1 PKM DYNC1H1 VCP TP53BP2

2.85e-0613531692129467282
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

HNF1B EIF4A3 INPPL1 SIPA1L3 RANBP9 PSMD2 OAT APP YWHAB DIS3 DHX30 DNAH1 CLIC1 PKM TMPO AFF1 DYNC1H1 AFF4 VCP TP53BP2

3.08e-0612471692027684187
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

KDM5B USP13 WASHC4 EIF4A3 SIPA1L3 RANBP9 PSMD2 OAT TSG101 APP YWHAB DHX30 CORO2B NOMO2 PKM OLFM1 ASTN1 DYNC1H1 AFF4 VCP

4.81e-0612851692035914814
Pubmed

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.

NOMO1 NOMO2 NOMO3

6.20e-068169315257293
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NR2F6 NDOR1 MYO10 INPPL1 DOCK9 SIPA1L3 ADGRL1 ATP13A2 PLEKHH3 DHX30 MDN1 PER2 TRIB3 SBF1 XPO6 PI4KA RIPOR1 DYNC1H1

8.04e-0611051691835748872
Pubmed

Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure.

PAF1 AFF1 AFF4

9.27e-069169324565118
Pubmed

Substrate-driven assembly of a translocon for multipass membrane proteins.

NOMO1 NOMO2 NOMO3

9.27e-069169336261522
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

TBC1D19 ELOA ERO1A DIDO1 EVPL LPIN1 COG6 PKM TMPO DYNC1H1

1.16e-053601691033111431
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

DIDO1 TRANK1 MDN1 PER2 XPO6 DYNC1H1

1.23e-0510416969205841
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

WASHC4 EIF4A3 SIPA1L3 TSG101 STRIP1 DHX30 COPS7A PHKB NUP155 PER2 PIGR MYCBP KCTD10 PKM TMPO GNAT2 DYNC1H1 VCP

1.45e-0511551691820360068
Pubmed

Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA.

ADRM1 PSMD2 TMPO DYNC1H1 VCP

1.67e-0565169534645483
Pubmed

Defining the membrane proteome of NK cells.

ATP7B LONP2 EIF4A3 ERO1A DOCK9 PSMD2 DDX51 PIGU YWHAB DIS3 NOMO1 MDN1 NUP155 CLIC1 PI4KA TMPO PLSCR1 DYNC1H1

1.69e-0511681691819946888
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

ABCB7 ATP7B EIF4A3 ERO1A PSMD2 APP RRM1 DHX30 NOMO1 NUP155 MSMO1 NOMO2 TMPO TYW1 PCDH9 NOMO3

1.80e-059521691638569033
Pubmed

Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription.

NR2F6 PLSCR1 TP53BP2

1.81e-0511169321247419
Pubmed

HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.

PAF1 AFF1 AFF4

1.81e-0511169320471949
Pubmed

An ER translocon for multi-pass membrane protein biogenesis.

NOMO1 NOMO2 NOMO3

1.81e-0511169332820719
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

ABCB7 ADRM1 ABCC11 YWHAB MDN1 COG6 CLIC1 EIF2B4 PKM RASEF PZP DYNC1H1 VCP

1.84e-056471691326618866
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

INPPL1 DOCK9 SIPA1L3 EVPL YWHAB STAT2 CLIC1 PI4KA PKM TMPO PLSCR1 TP53BP2

2.27e-055651691225468996
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

DENND2A SIPA1L3 ADGRL1 PSMD2 OAT TSG101 YWHAB STRIP1 DHX30 PHKB CORO2B SBF1 PI4KA KCTD10 PKM TMPO GNAQ DYNC1H1 VCP TP53BP2

2.28e-0514311692037142655
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CABLES2 YWHAB DNAJC2 DHX30 PHKB NUP155 PI4KA A2ML1 PKM PZP VCP

2.29e-054751691131040226
Pubmed

Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.

BACE1 APP

2.35e-052169227687728
Pubmed

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

BACE1 APP

2.35e-052169223931995
Pubmed

Distinct roles of two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA polymerase II transcription elongation.

AFF1 AFF4

2.35e-052169237528066
Pubmed

Molecular characterization of the murinoglobulins.

A2ML1 PZP

2.35e-05216921840592
Pubmed

The enhancement of amyloid precursor protein and beta-site amyloid cleavage enzyme 1 interaction: amyloid-beta production with aging.

BACE1 APP

2.35e-052169220127045
Pubmed

APP knockout mice experience acute mortality as the result of ischemia.

BACE1 APP

2.35e-052169222912719
Pubmed

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.

BACE1 APP

2.35e-052169219074428
Pubmed

BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism.

BACE1 APP

2.35e-052169229632166
Pubmed

APP is phosphorylated by TrkA and regulates NGF/TrkA signaling.

NTRK1 APP

2.35e-052169221849536
Pubmed

The BACE1-Specific DNA Aptamer A1 Rescues Amyloid-β Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease.

BACE1 APP

2.35e-052169231513457
Pubmed

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.

BACE1 APP

2.35e-052169221500352
Pubmed

Triptolide treatment reduces Alzheimer's disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD.

BACE1 APP

2.35e-052169225481013
Pubmed

AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.

AFF1 AFF4

2.35e-052169224843025
Pubmed

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.

BACE1 APP

2.35e-052169222801501
Pubmed

Segregation of the membrane cargoes, BACE1 and amyloid precursor protein (APP) throughout the Golgi apparatus.

BACE1 APP

2.35e-052169235076977
Pubmed

Functions of Aβ, sAPPα and sAPPβ : similarities and differences.

BACE1 APP

2.35e-052169222150401
Pubmed

Cre-LoxP and tamoxifen-induced deletion of ovarian quiescin sulfhydryl oxidase 2 showed disruption of ovulatory activity in mice.

NDOR1 QSOX2

2.35e-052169238504307
Pubmed

The histidine composition of the amyloid-β domain, but not the E1 copper binding domain, modulates β-secretase processing of amyloid-β protein precursor in Alzheimer's disease.

BACE1 APP

2.35e-052169225171714
Pubmed

Gene expression profiles of APP and BACE1 in Tg SOD1G93A cortical cells.

BACE1 APP

2.35e-052169219214738
Pubmed

Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors.

BACE1 APP

2.35e-052169219372755
Pubmed

sAβPPα is a Potent Endogenous Inhibitor of BACE1.

BACE1 APP

2.35e-052169226401691
Pubmed

Casein kinase II-mediated phosphorylation of lipin 1β phosphatidate phosphatase at Ser-285 and Ser-287 regulates its interaction with 14-3-3β protein.

YWHAB LPIN1

2.35e-052169230617183
Pubmed

Hepatitis, testicular degeneration, and ataxia in DIDO3-deficient mice with altered mRNA processing.

NDOR1 DIDO1

2.35e-052169235672775
Pubmed

Murinoglobulin, a novel protease inhibitor from murine plasma. Isolation, characterization, and comparison with murine alpha-macroglobulin and human alpha-2-macroglobulin.

A2ML1 PZP

2.35e-05216922578455
Pubmed

p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis.

UBXN2B VCP

2.35e-052169217141156
Pubmed

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

BACE1 APP

2.35e-052169218263584
Pubmed

Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.

BACE1 APP

2.35e-052169215452128
Pubmed

Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)).

BACE1 PLSCR1

2.35e-052169212586838
Pubmed

Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP/BACE1 interactions.

BACE1 APP

2.35e-052169224613671
Pubmed

Biophysical alterations in lipid rafts from human cerebral cortex associate with increased BACE1/AβPP interaction in early stages of Alzheimer's disease.

BACE1 APP

2.35e-052169225147112
Pubmed

Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents.

NTRK1 APP

2.35e-052169228197073
Pubmed

A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation.

RANBP9 APP

2.35e-052169219729516
Pubmed

Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice.

BACE1 APP

2.35e-052169219683527
Pubmed

Neuronal migration defects in the Loa dynein mutant mouse.

DNAH1 DYNC1H1

2.35e-052169221612657
Pubmed

Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice.

A2ML1 PZP

2.35e-052169230814992
Pubmed

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

BACE1 APP

2.35e-052169210531052
Pubmed

Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein.

BACE1 APP

2.35e-052169220833873
Pubmed

Lysophosphatidic acid induces increased BACE1 expression and Aβ formation.

BACE1 APP

2.35e-052169223036978
Pubmed

Asynchronous evolutionary origins of Aβ and BACE1.

BACE1 APP

2.35e-052169224361992
Pubmed

Cholesterol-dependent energy transfer between fluorescent proteins-insights into protein proximity of APP and BACE1 in different membranes in Niemann-Pick type C disease cells.

BACE1 APP

2.35e-052169223443094
Pubmed

Pancortins interact with amyloid precursor protein and modulate cortical cell migration.

APP OLFM1

2.35e-052169222992957
Pubmed

APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions.

BACE1 APP

2.35e-052169225247712
Pubmed

ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein.

TSG101 ATP13A2

2.35e-052169225392495
Pubmed

cGMP favors the interaction between APP and BACE1 by inhibiting Rab5 GTPase activity.

BACE1 APP

2.35e-052169231992816
Pubmed

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation.

BACE1 APP

2.35e-052169222491325
Pubmed

Identification of four genes coding for isoforms of murinoglobulin, the monomeric mouse alpha 2-macroglobulin: characterization of the exons coding for the bait region.

A2ML1 PZP

2.35e-05216927528167
Pubmed

Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.

BACE1 APP

2.35e-052169218182389
Pubmed

Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein.

BACE1 APP

2.35e-052169215197182
Pubmed

Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.

BACE1 APP

2.35e-052169226642089
Pubmed

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

BACE1 APP

2.35e-052169216354928
Pubmed

BACE cleavage of APP does not drive the diabetic phenotype of PLB4 mice.

BACE1 APP

2.35e-052169237137417
Pubmed

ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.

BACE1 APP

2.35e-052169230315100
Pubmed

Aβ modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism.

INPPL1 APP

2.35e-052169231664099
Pubmed

Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.

BACE1 APP

2.35e-052169222553349
Pubmed

APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons.

BACE1 APP

2.35e-052169237355492
Pubmed

Natural compounds that modulate BACE1-processing of amyloid-beta precursor protein in Alzheimer's disease.

BACE1 APP

2.35e-052169223021373
Pubmed

Impact of cholesterol level upon APP and BACE proximity and APP cleavage.

BACE1 APP

2.35e-052169218374657
Pubmed

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein.

BACE1 APP

2.35e-052169223613819
Pubmed

Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription.

BACE1 APP

2.35e-052169216449801
Pubmed

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.

BACE1 APP

2.35e-052169226414661
Pubmed

β-Secretase-1: In Silico Drug Reposition for Alzheimer's Disease.

BACE1 APP

2.35e-052169237175873
Pubmed

Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects.

BACE1 APP

2.35e-052169222843498
Pubmed

The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.

BACE1 APP

2.35e-052169215522224
InteractionCTAGE1 interactions

CTAGE6 CTAGE8 CTAGE15 CTAGE4

8.97e-07101664int:CTAGE1
InteractionENO1 interactions

NEURL2 LONP2 NTRK1 INPPL1 RANBP9 PSMD2 PAF1 RRM1 YWHAB STRIP1 DHX30 NOMO1 PER2 CLIC1 NOMO2 MYCBP PKM DYNC1H1 VCP

5.43e-0670116619int:ENO1
Cytoband7q35

CTAGE6 CTAGE8 CTAGE15 CTAGE4

5.22e-055516947q35
Cytoband5q31

PCDHGB3 PCDHA6 KLHL3 TAF7 AFF4

7.05e-0511516955q31
CytobandEnsembl 112 genes in cytogenetic band chr7q35

CTAGE6 CTAGE8 CTAGE15 CTAGE4

1.07e-04661694chr7q35
Cytoband20q13.33

CABLES2 CDH26 ADRM1 DIDO1

2.15e-0479169420q13.33
CytobandEnsembl 112 genes in cytogenetic band chr20q13

CABLES2 CDH26 NEURL2 ADRM1 DIDO1 YWHAB OSBPL2

1.02e-034221697chr20q13
GeneFamilyCTAGE family

CTAGE6 CTAGE8 CTAGE15 CTAGE4

1.34e-06151044907
GeneFamilyAF4/FMR2 family|Super elongation complex

AFF1 AFF4

1.95e-04410421145
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

A2ML1 PZP

1.15e-03910421234
GeneFamilyAF4/FMR2 family|Super elongation complex

AFF1 AFF4

1.15e-03910421280
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

NET1 MYO10 DOCK9 PLEKHH3 SBF1 SKAP2

1.22e-032061046682
ToppCellPND07-28-samps-Myeloid-Macrophage-macrophage-C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

MGAM NR2F6 BPIFB3 OLFM3 SHOC1 PZP

6.13e-078016963413ac5e1c1e59eab6a83b889b870a8db4efccb9
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CAMK1G EFHC1 LUZP2 ZKSCAN4 PZP PCDH9 NEK11

2.36e-0615716971f21d78a467fe22c5ab75d0917b840c1ac93f32c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DENND2A MYO10 NUP210L HMCN1 MSMO1 MYCBP PCDH9

2.79e-0616116974bb7bae54ba3bdf46b525c01f5ad3db8e49819cb
ToppCelldroplet-Marrow-nan-21m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROGDI ERO1A APP RRM1 ALAS1 PLSCR1 TANGO6

7.75e-0618816971526e271411e381eae7a342003002276f83f47a3
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP13 HNF1B CSF3R MSMO1 HPN RASEF PCDH9

1.02e-0519616977e5addaa844e66f8160e05858c341866a80aed23
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF1B BRINP3 NET1 MSMO1 CLIC1 HPN SIGLEC11

1.05e-0519716975027787ab3ce60e1ddcb99e3a01f40bb07b05804
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KDM5B NET1 RAET1G OAT PLEKHH3 PKM ALDH1A1

1.12e-051991697ba284f984909504221900bca5ea12ada5b2ffd9f
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NR2F6 NET1 OAT PER2 PIGR PKM ALDH1A1

1.16e-0520016978c4c396e99be6131a8fa60d86214d561031b12bf
ToppCellfacs-Lung-EPCAM-3m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM TNFSF14 ACOD1 CELA3B CSF3R LUZP2

3.38e-051601696b73f07a0088936fbc3656a05710a67f38b4ae551
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM TNFSF14 ACOD1 CELA3B CSF3R LUZP2

3.38e-051601696b88876a58fea2066468e74dcc439c8561130a910
ToppCellfacs-Kidney-nan-24m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HNF1B CELA3B PIGR HPN COASY PZP

4.15e-051661696fe87b444fc0ef6fc20c646c9d2c3c8ce916a70c0
ToppCelllung-Ciliated_Epithelia|lung / shred on tissue and cell subclass

EFHC1 CSF3R MYCBP ALDH1A1 SPAG17 NEK11

4.29e-05167169626cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCell343B-Fibroblasts-Fibroblast-H|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

BRINP3 ERO1A ASTN1 TNFAIP1 TP53BP2 TANGO6

5.06e-051721696eb199c279fe8a2551121db37e9556893197d33ff
ToppCell343B-Fibroblasts-Fibroblast-H-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

BRINP3 ERO1A ASTN1 TNFAIP1 TP53BP2 TANGO6

5.06e-051721696709c6b77a7a52b873eefb6caca28a41291d384af
ToppCelldroplet-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte-type_1_alveolar_epithelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HNF1B SIPA1L3 ITGA7 PIGR HPN ARHGAP8

6.31e-051791696ca70a5518c5a5392e088c103e0cb44aa084f5332
ToppCelldroplet-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HNF1B SIPA1L3 ITGA7 PIGR HPN ARHGAP8

6.31e-051791696c451b074b04eb5d6c575c6abaedda579c6744bbf
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Smooth_muscle_cells|Fibroblasts / Location, Cell class and cell subclass

CCP110 BRINP3 DOCK9 ITGA7 SWSAP1 EIF2B4

6.31e-05179169683506e00fe99b6450efd2f13f716926a0a4b03cd
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCP110 DNAH1 EFHC1 NEK5 SPAG17 PZP

6.51e-05180169692fb01b91261b3103454924cde56add337b41844
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

USP13 APOBEC3A CSF3R C1orf159 ALDH1A1 NEK11

6.71e-0518116962b9b460239d67fd480cee60820cdb306109d3567
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1|bone_marrow / Manually curated celltypes from each tissue

ROGDI ITGA7 CSF3R BRCA2 PKM GNAQ

6.71e-051811696ccd0ed30cea3fb41d34f28b3e8d80a94493bef3c
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

USP13 APOBEC3A CSF3R C1orf159 ALDH1A1 NEK11

6.71e-0518116962a1aa4a0ec7bc367857beaff543135e4345c835b
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MGAM PLEKHH3 APOBEC3A IFNGR2 CSF3R XPO6

6.92e-051821696dc32f8f6a3b13918eb8e93c018f5823d86344080
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

CSF3R MSMO1 PIGR HPN RASEF PCDH9

7.35e-051841696369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TNFSF14 DOCK9 CSF3R MSMO1 OSMR PCDH9

7.80e-051861696acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCellcellseq-Immune-Hematopoietic-Granulocytic-Neutrophil|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MGAM TNFSF14 APOBEC3A CSF3R XPO6 SKAP2

8.52e-051891696fedab592be1d6520325b8c1b659b0a4dc3f4fe4d
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

APOBEC3A ACOD1 IFNGR2 CSF3R ALDH1A1 PLSCR1

8.77e-051901696e1c02fe6fa43a36381cb9f02569fa9b1c5f5efdc
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

APOBEC3A ACOD1 IFNGR2 CSF3R ALDH1A1 PLSCR1

8.77e-0519016966de15ec88426fbf52acb0a8371f82cf03b6a6237
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

APOBEC3A ACOD1 IFNGR2 CSF3R ALDH1A1 PLSCR1

9.02e-05191169681f77bf497b8e0ae0affe7d5f4f00446547229f6
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-6|TCGA-Stomach / Sample_Type by Project: Shred V9

ERO1A PSMD2 IFNGR2 MYCBP PKM TMPO

9.29e-0519216964e689bca7a242f8482e25f273656e2caba8821c0
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP13 CSF3R MSMO1 HPN OLFM1 PCDH9

9.55e-0519316968646e573f2d2ff175f3d02bfdf214e65f3b614d3
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_granulocytic-basophil|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MYO10 NTRK1 EVPL CLIC1 ALDH1A1 ATP6V0A2

9.83e-051941696aca009b9f1f320c0a65ea16df6595d7ede0b1fda
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_3|Classical_Monocyte / Disease condition and Cell class

ELOA WASHC4 ERO1A YWHAB PKM SKAP2

1.04e-04196169615397ec27167bb2fb6fec120b68bf38fc71b2670
ToppCellmetastatic_Lymph_Node-Endothelial_cells-Tumor_ECs|Endothelial_cells / Location, Cell class and cell subclass

TSG101 EIF2B4 OLFM1 TAF7 PLSCR1

1.06e-041231695de29861800d083e4977afbef59c1a81336824703
ToppCellBronchial_Brush-Epithelial|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

APP EFHC1 PIGR NEK5 ALDH1A1 SPAG17

1.07e-041971696272c7f4e582ef57564450540242b0db766b78328
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IFNGR2 CSF3R ALDH1A1 GNAQ SKAP2 PLSCR1

1.07e-0419716962afc23f7394d9b40bdf06527c5e6b553e1b02dca
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MGAM UBXN2B CSF3R CLIC1 XPO6 SKAP2

1.07e-041971696340ce4fef244176fb52e38ffbcbdfda5ac3467dd
ToppCellASK440-Epithelial-Type_2|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

ELOA DOCK9 CSF3R MSMO1 PIGR HPN

1.07e-04197169608d5bbeb77a4152af1c783bc958afcae24667767
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IFNGR2 CSF3R ALDH1A1 GNAQ SKAP2 PLSCR1

1.07e-04197169615bcfe6105c0b508811fb9bba0bc4312fea04f4c
ToppCell3'-Child04-06-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF1B MYO10 OAT APP PIGR ALDH1A1

1.10e-041981696a4543d636501a1b5b46c14a661ce9d169947c82c
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MGAM BRINP3 NET1 MYOZ2 ITGA7 PZP

1.10e-041981696d1827e3707b929e3a3562989a0c11537d344e164
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-PNs|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

KDM5B CORO2B TRIB3 COG6 NANS PKM

1.10e-0419816966408653e956fedb284fa5e69ba8f4d620731f556
ToppCellBiopsy_Other_PF-Epithelial-AT2|Biopsy_Other_PF / Sample group, Lineage and Cell type

CSF3R MSMO1 PIGR HPN RASEF PCDH9

1.13e-0419916969a65acfe9bf500db72142469cf17bf0973540001
ToppCellSepsis-Bac-SEP-Lymphocyte-T/NK-dn_T|Bac-SEP / Disease, condition lineage and cell class

KDM5B DDX51 PIGU TRIB3 EIF2B4 C1orf159

1.13e-0419916964150a479b80596accf679b37aa9b0ac15cc132b2
ToppCellLPS_only-Mesenchymal_fibroblastic|LPS_only / Treatment groups by lineage, cell group, cell type

DENND2A MYO10 OLFM1 ALDH1A1 OSMR PZP

1.13e-041991696211c3a08f2d484ab7a3368006767289088f0d957
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NET1 OAT PER2 PIGR PKM ALDH1A1

1.13e-041991696fbd39d34636137d1b877dd8815d58f124990136b
ToppCellhematopoetic_progenitors-CD34+_MPP|hematopoetic_progenitors / Lineage and Cell class

RRM1 YWHAB YEATS4 CSF3R PKM TMPO

1.13e-041991696ec127c5a374a005ecf1377fb9bd245a7244505bf
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NET1 OAT PER2 PIGR PKM ALDH1A1

1.13e-0419916966977f939ddbc47d4921f36c0a61a205259fe1284
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts|LPS_only / Treatment groups by lineage, cell group, cell type

DENND2A MYO10 OLFM1 ALDH1A1 OSMR PZP

1.13e-0419916961a0add79f4e34078b3475eb11c85a4234bda197c
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ERO1A APP TRIB3 PKM OSMR TAF7

1.13e-041991696cfe6f881a86607544e1413ef38e4b6797ef1a61c
ToppCellmLN-Mast_cell-Mast|mLN / Region, Cell class and subclass

NTRK1 APOBEC3A TRIB3 OLFM1 ALDH1A1 ATP6V0A2

1.16e-04200169681ea6e7a3940277751faf9097b30198159998c7b
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CDH26 DNAH1 EFHC1 PIGR A2ML1 SPAG17

1.16e-042001696da12821e8a0657869ca0f75d351cce2d7605a505
ToppCellSigmoid-T_cell-cycling_gd_T|T_cell / Region, Cell class and subclass

CABLES2 STYK1 BRCA2 C1orf159 ZKSCAN4 QSOX2

1.16e-0420016964e489ecf472857357d45e9f6c7a812aa48b72ebf
ToppCellmLN-Mast_cell|mLN / Region, Cell class and subclass

NTRK1 APOBEC3A TRIB3 OLFM1 ALDH1A1 ATP6V0A2

1.16e-0420016969a5f1d99d8d160923d4d0fbbf9ad48a26f8a4fad
ToppCellmLN-(7)_Mast_cell-(70)_Mast|mLN / shred on region, Cell_type, and subtype

NTRK1 APOBEC3A TRIB3 OLFM1 ALDH1A1 ATP6V0A2

1.16e-042001696a6c258cae678be581b1d85cf3446c65c34b13499
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ERO1A APP TRIB3 PKM OSMR TAF7

1.16e-0420016965a5d70bfb6d253f272cc1f8516205fcfe8106291
ToppCellSigmoid-(1)_T_cell-(18)_cycling_gd_T|Sigmoid / shred on region, Cell_type, and subtype

CABLES2 EID2 STYK1 XPO6 C1orf159 ZKSCAN4

1.16e-0420016966e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCellSigmoid-T_cell-cycling_gd_T|Sigmoid / Region, Cell class and subclass

CABLES2 EID2 STYK1 XPO6 C1orf159 ZKSCAN4

1.16e-0420016969769185abae084ffac36420c749625e679b70ca8
ToppCellmLN-(7)_Mast_cell|mLN / shred on region, Cell_type, and subtype

NTRK1 APOBEC3A TRIB3 OLFM1 ALDH1A1 ATP6V0A2

1.16e-04200169613bca944fbdbc0be6687eca82c62a4d231ab94f0
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CDH26 DNAH1 EFHC1 PIGR A2ML1 SPAG17

1.16e-04200169672c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCellileum-Epithelial_Stem_Cells|ileum / shred on tissue and cell subclass

BACE1 RRM1 PIGR HPN ARHGAP8

1.19e-041261695a8ed48cbd1e207fd1aaad454fda9f329eb22aa83
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MGAM PCDHGB3 CSF3R XPO6 SHOC1

1.28e-04128169558639cfdc70ff6764adcc5c1ce9eba9d033b8209
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MGAM PCDHGB3 CSF3R XPO6 SHOC1

1.28e-0412816959b3c57d559a5ed8d590dd89b64a57a3227d8c684
Diseaseglucose metabolism decline measurement, cingulate cortex measurement

CDH23 TYW1

1.05e-0391622EFO_0007738, EFO_0009392
Diseaseoverall survival

OSMR PCDH9

1.05e-0391622EFO_0000638
Diseasemean platelet volume

PCDHGB3 RBBP5 NUP210L BACE1 PSMD2 YWHAB EFHC1 TRANK1 OSBPL2 CLIC1 PI4KA AFF1 RIPOR1 TAF7

1.55e-03102016214EFO_0004584
Diseaseatopic eczema, childhood onset asthma, atopic march

EFHC1 AP5B1

1.59e-03111622EFO_0000274, EFO_0007755, MONDO_0005405
Diseasemicrofibrillar-associated protein 2 measurement

ATP13A2 A2ML1

1.59e-03111622EFO_0801801
Diseasemyeloid white cell count

TNFSF14 RBBP5 NTRK1 CDH23 PSMD2 CELA3B EFHC1 OLFM3 CSF3R XPO6 SFXN2 OLFM1 SPAG17

2.06e-0393716213EFO_0007988
DiseaseDisease Exacerbation

ATP7B ABCC11 RRM1 COPS7A VCP

2.22e-031651625C0235874
DiseaseNeurodegeneration with brain iron accumulation

ATP13A2 COASY

2.25e-03131622cv:C2931845
Diseaseputamen volume change measurement

SYDE2 DCHS1

2.25e-03131622EFO_0021495
Diseaseneutrophil measurement

PSMD2 YWHAB TRIB3 OLFM1 PLSCR1

3.01e-031771625EFO_0803548

Protein segments in the cluster

PeptideGeneStartEntry
AEPDPILDNYVLLVV

CBARP

36

Q8N350
DPEAIRDLILQLDYP

BRINP3

676

Q76B58
TILNYLRDGAVPLPE

KCTD10

86

Q9H3F6
ILPQQYLRPVEDVAT

BACE1

361

P56817
ELLDKYLIPNATQPE

YWHAB

101

P31946
LPLISNQYIELDINP

BPIFB3

231

P59826
LIDLKTRYPILENPE

CCNH

171

P51946
ADYLAEARNLPPLTE

COPS7A

76

Q9UBW8
ATPQPYLGLVLEELR

CTAGE4

6

Q8IX94
ATPQPYLGLVLEELR

CTAGE6

6

Q86UF2
ATPQPYLGLVLEELR

CTAGE8

6

P0CG41
ATPQPYLGLVLEELR

CTAGE15

6

A4D2H0
LNVLLYETPRVPDNS

TNFAIP1

251

Q13829
LALENYITALQAVPP

APP

471

P05067
VLYNPSVISPEELRA

ATP7B

401

P35670
LDLVPSLQLDPAQIY

APOBEC3A

76

P31941
EEPLLLPRAQSVLYQ

ADGRL1

1341

O94910
IAEELPNYLVTLPAR

A2ML1

16

A8K2U0
TPDLPVLLTDLKIQY

ALDH1A1

6

P00352
PYVPLLEAEEVRLSQ

DHX30

401

Q7L2E3
PRAAEIPVYLEIVDI

CDH23

2381

Q9H251
LLEQALKTYPVNTPE

DNAJC2

561

Q99543
LVQRIIYEVDDPSLP

TP53BP2

941

Q13625
PVLLEVTKAAPIYEL

ASTN1

966

O14525
PPIGVQIVDYLLRQE

ASTN1

1056

O14525
SEPDDRYPLIVKIDL

AFF4

706

Q9UHB7
LKRLYPAVDEQETPL

RANBP9

151

Q96S59
LQQISLPELPGEYVI

PZP

1306

P20742
VSELIAQLLRAEPYP

NR2F6

166

P10588
PPLLRDGENYVVLLD

NOMO3

1101

P69849
YQSEVLAERLPLTPV

OSMR

21

Q99650
NLVEPRLIQPYEHVI

RASEF

156

Q8IZ41
LASLPLDRIPYNAVL

QSOX2

381

Q6ZRP7
DRPQLPYLEAFILET

CYP1A2

361

P05177
LNDLDRVADPAYLPT

GNAQ

161

P50148
PLFPVEEQRVLIYES

PCDHA6

131

Q9UN73
VYRQPIPVQELVLED

NET1

426

Q7Z628
EPDAVDPVLNYRLSI

MDGA1

666

Q8NFP4
AVEYVDSLLPENPLQ

MSMO1

16

Q15800
LDYELEPQPQLIVVA

DCHS1

536

Q96JQ0
LQALAQAPPVYLDVL

NTRK1

781

P04629
PPLLRDGENYVVLLD

NOMO2

1101

Q5JPE7
QQLLAYDVLPPLVAL

KPNA7

361

A9QM74
FRPQLPAYESLVQEI

MDN1

3316

Q9NU22
EKPYPIAEVEQLDRL

LONP2

116

Q86WA8
PPLAQAIRDYVNSLL

TMPO

371

P42166
QAINYPTVPRGEELL

ALAS1

556

P13196
PEQVVQEYLELIGRP

MGAM

356

O43451
LDVPQVSLIINYDLP

EIF4A3

341

P38919
YLPQDLIETPVLVQL

PER2

356

O15055
PPGLEYLSQIDQILI

PLSCR1

96

O15162
LIYTIREELPENVPI

PCDH9

26

Q9HC56
NLIPKYLTPEVIQEE

NEK5

261

Q6P3R8
LRPLIPVLEEYKADA

OLFM1

161

Q99784
PDLEVLRAQKPTVEY

EVPL

1236

Q92817
PILIIPKILEYSEEQ

ABCC11

181

Q96J66
PPLLRDGENYVVLLD

NOMO1

1101

Q15155
AAIPPLEEVYSLQRL

MYO10

1846

Q9HD67
PSAIEILKIPYLDEQ

NEK11

276

Q8NG66
LPSNPEAIVLDIDYK

PI4KA

1776

P42356
ILYRDVAFLNPVDPI

LRRC75B

71

Q2VPJ9
DIPEENLSLAVIYPQ

LPIN1

211

Q14693
LVALYEEPEKPNSAL

MYCBP

31

Q99417
DPILYRPVAVALDTK

PKM

101

P14618
PLSRPAAAYEEALQL

MIGA2

311

Q7L4E1
PEIQELYQTLLAKPS

KDM5B

1361

Q9UGL1
KLQPEALEPIYSLEL

AP5B1

681

Q2VPB7
YPELVLKAPLDREEQ

PCDHGB3

191

Q9Y5G1
SLRLLNLVYDVTPPE

EIF2B4

481

Q9UI10
LLDQLYELNVLPPTA

NEURL2

171

Q9BR09
LDQYAPDVAELIRTP

PIGU

116

Q9H490
AVLLRSDQEPLYPVQ

HPN

41

P05981
DSYPVVNLINEPLVI

NDOR1

41

Q9UHB4
EIGVPLPRLLEVYDQ

NUP155

1291

O75694
SKALLYLPIAPEVED

RBBP5

396

Q15291
EDSLQYDVRVLVPPI

HMCN1

2856

Q96RW7
PENLLYLTPEENSKI

CAMK1G

146

Q96NX5
RALYLEPTEDLAPAQ

SBF1

696

O95248
YNIILESKPEPQVEL

RIMS2

736

Q9UQ26
LINPDTYRIDPNVLL

PAF1

86

Q8N7H5
DRYLSAPDNLLIPQL

COG6

586

Q9Y2V7
LETYGAQPPIELLRQ

DNAH1

2301

Q9P2D7
ISIPVKSYPQLLVDE

ATP13A2

221

Q9NQ11
LYKVIQEPQSELLEP

FAM126A

41

Q9BYI3
RAQLELYPEPLLVAN

FAM126A

266

Q9BYI3
NLIKDLEPTTPQEYI

TTC26

306

A0AVF1
LVIPLEQTGRIEPNY

CORO2B

66

Q9UQ03
PKLIEPLDYENVIVQ

DOCK9

46

Q9BZ29
SDEILFQIYQPREPL

BRCA2

3041

P51587
AYVPELTQQFPLKLE

DENND2A

581

Q9ULE3
AIQANYRPLPSLELI

ELOA

516

Q14241
SKLLQPLVPRYEEAL

DDX51

636

Q8N8A6
RALEEQLLKYSPDPV

CHIC2

16

Q9UKJ5
VKDLYLIPLSAQDPV

DIDO1

1156

Q9BTC0
LPDKLQEALLPVVDY

CELA3B

171

P08861
QDLPLLAEVIPDPYV

CCP110

211

O43303
VDLPYPASSRLQELL

BRF2

256

Q9HAW0
ILDQVELRAGYPPAI

CSF3R

111

Q99062
LENYPIAPGRIQELE

EID2

161

Q8N6I1
IQSPEAEYVDLLLNP

ERO1A

171

Q96HE7
PLLPALVLSTRQDYE

LUZP2

11

Q86TE4
SIPLQIEEYLKDPTQ

IFNGR2

286

P38484
IEEYLKDPTQPILEA

IFNGR2

291

P38484
ILNVIKPLDYETRPA

CDH26

336

Q8IXH8
RYLAVLESPIPEDKD

EFHC1

421

Q5JVL4
QVRELLSKVELEYPP

ACOD1

361

A6NK06
NPLLVQDVESYDPVL

DYNC1H1

3631

Q14204
LPLLPRDYLVQTVEE

KLHL3

241

Q9UH77
DQLVYKTLDPADRLP

ITGA7

281

Q13683
LYKALPQSVDPLDIE

FHIP2A

316

Q5W0V3
ADPQYLLLLEVQLHP

C1orf159

306

Q96HA4
LELALYLPENQVLPH

CABLES2

456

Q9BTV7
DELLPLIPVLEQYKT

OLFM3

151

Q96PB7
DELISPKDIDPVQRY

PHKB

456

Q93100
YEPLKALNPVEVALV

NUP210L

651

Q5VU65
LADLYVIIPATLNPI

OR52I1

281

Q8NGK6
LLADLYVIIPATLNP

OR52I2

306

Q8NH67
YDTPPILKELQALNT

HNF1B

86

P35680
PSPLITKQLYEAVLD

SYDE2

901

Q5VT97
ELTVVLRYIPPEENL

SYTL5

546

Q8TDW5
ELESQFILRLPPEYA

TAF7

11

Q15545
APALPSDLLVNVYIN

ROGDI

181

Q9GZN7
ALIEKPTVDPIYIAL

NUGGC

91

Q68CJ6
DPEAVALIYLRNPIL

PLEKHH3

221

Q7Z736
ELPVSYLEPKLQDTI

SFXN2

291

Q96NB2
LTEENIPENPLRFLY

STAT2

651

P52630
QIPLERIIVETDAPY

TATDN2

696

Q93075
QYINPDLLVDVLPLV

TMCO5B

266

A8MYB1
SLRDYTNLPEAAPLL

NXN

381

Q6DKJ4
YPLPEEIRNLLADVE

SKAP2

11

O75563
REPLLTLVKEIVPYN

PSMD2

181

Q13200
LNQLERITDPEYLPS

GNAT2

156

P19087
VEQVPAETLYQGLLP

STRIP1

501

Q5VSL9
PLKDALEYVIPELNI

SIPA1L3

581

O60292
RQLPTLKPILADIEY

INPPL1

801

O15357
KELLNPVPEIINYVD

SHOC1

201

Q5VXU9
SAYPLQPEDVNLRVI

NANS

186

Q9NR45
PEPQEAAYLIALLLD

SWSAP1

106

Q6NVH7
PNPQLIYDDEIPSLK

DIS3

881

Q9Y2L1
IIPYNDLPALERALQ

OAT

206

P04181
PFNPLLGETYELIRE

OSBPL2

151

Q9H1P3
YEPVKIPTQSLLQDV

SPAG17

2006

Q6Q759
RAILKDPPVILYDEA

ABCB7

621

O75027
ESPELKPLPEDYRQQ

AFF1

306

P51825
LANADVQERLLPYLP

ADRM1

301

Q16186
ALKVLDNYLTSPLPE

CLIC1

136

O00299
LLPELLQPYTERVEH

COASY

236

Q13057
NNDIDEVIIPTAPLY

TSG101

311

Q99816
AVLQVPELVVPELYA

STYK1

391

Q6J9G0
LVDPLIRKPDAYTEQ

TMEM9

111

Q9P0T7
PPSARDLQLALAELY

UBXN2B

21

Q14CS0
QLIYIPLPDEKSRVA

VCP

641

P55072
PRYPEELELLVSQQS

TNFSF14

171

O43557
IQSIPEIPDDLKQLY

RRM1

666

P23921
VQEALAVLEPYARLP

TRIB3

101

Q96RU7
YTIPKPDVITLLEQE

ZNF546

101

Q86UE3
TYPDPVIQELAVDLR

TANGO6

731

Q9C0B7
EVLLSAYDPQIPTRA

TANGO6

841

Q9C0B7
SDVYPEKILPDLLAQ

TANGO6

906

Q9C0B7
LDIQLENYIPKEPLT

RAET1G

106

Q6H3X3
LDIQLENYTPKEPLT

RAET1L

106

Q5VY80
QVLKPEPELVYEDLR

PIGR

236

P01833
VIPPEVLRYDEKLQS

ARHGAP8

186

P85298
VLLEYLERQLDEPAP

ZKSCAN4

126

Q969J2
LYGTNIPAVIEQPLE

TTC30A

621

Q86WT1
LDPIALKLLPYEQSS

WASHC4

61

Q2M389
LEYQKIPESINVPLD

TSTD3

56

H0UI37
FPAEIRNLEPVTQLY

TYW1

516

Q9NV66
LNQPIPILDVESEYI

XPO6

231

Q96QU8
DPNERPVTLYHLLKL

YEATS4

106

O95619
GELEYAVIDLNPRPL

TRANK1

1011

O15050
KVPQPERLDLVYTAL

RIPOR1

71

Q6ZS17
PVYAPKDFLEVLINL

TBC1D19

151

Q8N5T2
ALDLSVQYPPENLRV

SIGLEC11

346

Q96RL6
YEIALPNIEELPALV

USP13

146

Q92995
VYLVQEINRADIPLP

ATP6V0A2

66

Q9Y487
ISNDPELLEALYPKL

MYOZ2

156

Q9NPC6