Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA/DNA annealing activity

BLM SMARCA1

2.46e-0411432GO:1990814
GeneOntologyMolecularFunctionannealing activity

BLM SMARCA1

4.05e-0414432GO:0140666
HumanPhenoAbnormal adipose tissue morphology

BLM SAMHD1 FHL1 FHL2 SYNE1 CAP2 RNF113A

6.57e-06261167HP:0009124
HumanPhenoLipodystrophy

SAMHD1 FHL1 FHL2 SYNE1 CAP2

3.12e-05127165HP:0009125
HumanPhenoAbnormality of the voice

BLM SH3TC2 SAMHD1 FHL1 CWF19L1 SYNE1 RNF113A HDAC8

9.62e-05545168HP:0001608
HumanPhenoAbnormal muscle fiber emerin

FHL1 SYNE1

1.38e-046162HP:0030116
HumanPhenoAbsent muscle fiber emerin

FHL1 SYNE1

1.38e-046162HP:0030117
HumanPhenoEMG abnormality

SH3TC2 FHL1 FHL2 SYNE1 SMCHD1 CAP2

1.69e-04293166HP:0003457
HumanPhenoDecreased cervical spine flexion due to contractures of posterior cervical muscles

FHL1 SYNE1

1.92e-047162HP:0004631
DomainLIM

FHL1 FHL2 FHL5

4.65e-0469413PF00412
Domain-

FHL1 FHL2 FHL5

4.85e-04704132.10.110.10
DomainLIM_DOMAIN_2

FHL1 FHL2 FHL5

5.06e-0471413PS50023
DomainZnf_LIM

FHL1 FHL2 FHL5

5.06e-0471413IPR001781
DomainLIM_DOMAIN_1

FHL1 FHL2 FHL5

5.06e-0471413PS00478
DomainLIM

FHL1 FHL2 FHL5

5.06e-0471413SM00132
DomainDEAH_ATP_HELICASE

BLM SMARCA1

3.14e-0338412PS00690
Domain-

ZC3H7A RNF113A

3.48e-03404124.10.1000.10
DomainZnF_C3H1

ZC3H7A RNF113A

4.98e-0348412SM00356
Domainzf-CCCH

ZC3H7A RNF113A

5.18e-0349412PF00642
DomainZnf_CCCH

ZC3H7A RNF113A

7.19e-0358412IPR000571
DomainZF_C3H1

ZC3H7A RNF113A

7.19e-0358412PS50103
Pubmed

A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM.

FHL1 FHL2 FHL5

3.51e-08643311046156
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

SMARCA1 MRPS27 SRRT SAMHD1 GTF3C2 FHL1 CTSD PLRG1 CPSF3 SYNE1 SMCHD1 EPB41L2

1.01e-071425431230948266
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

BLM SMARCA1 SRRT ZC3H7A GTF3C2 FHL2 CTSD PLRG1 CPSF3 SMCHD1 EPB41L2

5.42e-071353431129467282
Pubmed

The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF.

FHL1 FHL2 FHL5

6.35e-071443315610731
Pubmed

Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes.

FHL1 FHL2

1.49e-06243224219103
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

BLM MRPS27 SRRT ZC3H7A SAMHD1 GTF3C2 PLRG1 SMCHD1

3.66e-0675943835915203
Pubmed

Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system.

FHL1 FHL2

4.48e-06343210906474
Pubmed

Slim defines a novel family of LIM-proteins expressed in skeletal muscle.

FHL1 FHL2

4.48e-0634328753811
Pubmed

The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle.

FHL1 FHL2

4.48e-06343210049693
Pubmed

Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.

FHL1 FHL2

8.94e-06443216407297
Pubmed

FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β.

FHL1 FHL2

1.49e-05543223086815
Pubmed

Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2.

FHL1 FHL2

2.23e-05643212432079
Pubmed

Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.

FHL1 FHL2

2.23e-05643222219185
Pubmed

FBXO25, an F-box protein homologue of atrogin-1, is not induced in atrophying muscle.

FBXO25 FBXO32

2.23e-05643216714087
Pubmed

Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.

FHL1 FHL2

4.16e-05843219139564
Pubmed

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

SMARCA1 SRRT ZC3H7A FHL1 CPSF3

4.29e-0531543526777405
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

SMARCA1 FHL2 PLRG1 SYNE1 SMCHD1

5.50e-0533243525693804
Pubmed

Efficient capture of cardiogenesis-associated genes expressed in ES cells.

FBXO32 CAP2

1.15e-041343217286962
Pubmed

The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein.

SAMHD1 FBXO25 DYRK3

1.16e-047643323940030
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

SMARCA1 MRPS27 SRRT FHL2 CTSD PLRG1 SMCHD1 EPB41L2

1.34e-04125743836526897
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

SMARCA1 SRRT PLRG1 CPSF3 SMCHD1 EPB41L2

1.53e-0466043632780723
Pubmed

A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.

FHL1 FHL2

1.55e-041543228094252
Pubmed

Genetic analysis of anterior posterior expression gradients in the developing mammalian forebrain.

FHL1 FHL2

2.26e-041843217150988
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

BLM SRRT GTF3C2 PLRG1 CPSF3 CWF19L1 SMCHD1

2.26e-04101443732416067
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

MRPS27 SRRT CLK1 PLRG1 CPSF3 SYNE1

2.34e-0471443628302793
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

BLM SRRT FHL1 SMCHD1 NSMCE1

2.35e-0445343529656893
Pubmed

Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.

FHL1 FHL2

2.52e-041943227171814
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

SMARCA1 GTF3C2 FHL2 PLRG1 SMCHD1

2.75e-0446943527634302
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

MRPS27 SRRT FHL2 CTSD PLRG1 CWF19L1 SMCHD1 EPB41L2

3.00e-04141543828515276
Pubmed

Human transcription factor protein interaction networks.

BLM SMARCA1 MRPS27 SRRT GTF3C2 FHL1 SOBP SMCHD1

3.20e-04142943835140242
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

BLM MRPS27 SRRT CLK1 PLRG1 CPSF3 SYNE1

3.35e-04108243738697112
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

SAMHD1 FBXO32 FHL1 CLK1 SYNE1

3.59e-0449743523414517
Pubmed

SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation.

SMARCA1 SMCHD1

4.05e-042443218425126
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

BLM MRPS27 ZC3H7A GTF3C2 LCMT2 PLRG1 SYNE1 EPB41L2

4.18e-04148743833957083
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

BLM MRPS27 SRRT ZC3H7A GTF3C2 FHL2 SYNE1 EPB41L2

4.37e-04149743831527615
Pubmed

Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.

FHL2 SYNE1

4.40e-042543212358155
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

SMARCA1 GTF3C2 SMCHD1 EPB41L2 CAP2

4.94e-0453343530554943
Pubmed

Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2.

FHL1 FHL2

5.14e-042743236899856
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

SRRT SAMHD1 GTF3C2 SMCHD1

7.50e-0433243432786267
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

SMARCA1 ZC3H7A SAMHD1 GTF3C2 CWF19L1

8.48e-0460143533658012
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

SRRT FHL1 CTSD PLRG1 EPB41L2

8.87e-0460743539147351
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

BLM SMARCA1 GTF3C2 SMCHD1 NSMCE1

8.93e-0460843536089195
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

SRRT ZC3H7A SAMHD1 CPSF3 SMCHD1 RNF113A

9.01e-0492243627609421
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

BLM SRRT GTF3C2 FHL2 PLRG1 CPSF3 SMCHD1

9.68e-04129443730804502
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

SRRT PLRG1 SMCHD1 RNF113A

9.93e-0435843432460013
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

BLM SRRT CTSD PLRG1 SMCHD1

1.22e-0365243531180492
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

SRRT FHL1 PLRG1 CPSF3 CWF19L1

1.23e-0365343533742100
GeneFamilyLIM domain containing

FHL1 FHL2 FHL5

1.14e-04592931218
GeneFamilyCyclins|F-boxes other

FBXO25 FBXO32

1.77e-0339292560
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

ZC3H7A SH3TC2

1.46e-02115292769
CoexpressionGSE38696_LIGHT_ZONE_VS_DARK_ZONE_BCELL_UP

OTULINL CTSD STX17 SYNE1 HDAC8

1.11e-05184425M9005
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CLEC2D SAMHD1 FBXO32 SYNE1 SMCHD1

9.96e-07187435e61c1755531469dd3850c9740474b5ad4e0499c1
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

FBXO32 TMEM178B FHL1 FHL2 CAP2

1.22e-0619543575fc81bddb246dca3b437fb60827b1d4fe416405
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBXO32 OTULINL FHL1 FHL2 CTSD

1.32e-0619843563f7d25201613bd3404c28fb936954190bca91d3
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBXO32 OTULINL FHL1 FHL2 CTSD

1.32e-06198435a73534b6ca202c277a70a52281d5b97a3e6cb8ef
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBXO32 OTULINL FHL1 FHL2 CTSD

1.32e-06198435d1e1bdd36c84e1bac21ba137f018defe98456a8c
ToppCellfacs-Lung-18m-Hematologic-Lymphocytic_NK_ILC-Alox5+_lymphocyte-Alox5+_lymphocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BLM FHL2 CWF19L1 DYRK3

2.53e-05177434b7cfa3776f58377e35830780650d236b5cceecee
ToppCellfacs-Lung-18m-Hematologic-Lymphocytic_NK_ILC-Alox5+_lymphocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BLM FHL2 CWF19L1 DYRK3

2.53e-051774341730e640986e50943bd781b7d949bcc5b7c12dde
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBXO32 FHL1 FHL2 CAP2

2.65e-05179434e860dca9b28ac5af61804bfd729cd39257cdb352
ToppCellfacs-Lung-EPCAM-18m-Lymphocytic-Alox5+_Lymphocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BLM FHL2 CWF19L1 DYRK3

2.71e-05180434b28363626f4d2a552abde3434cc1df2e2121aba5
ToppCellLV|World / Chamber and Cluster_Paper

FBXO32 TMEM178B FHL2 CAP2

2.71e-051804345ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCellfacs-Lung-EPCAM-18m-Lymphocytic-lymphocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BLM FHL2 CWF19L1 DYRK3

2.71e-0518043467b062f2ef7e20f392e00c646f4985c415d40de9
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBXO32 FHL1 FHL2 CAP2

2.83e-051824347b86703559438e2d5ef3dad963ee0d772513f313
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

SAMHD1 PIK3CG FHL5 EPB41L2

2.95e-0518443467164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellcontrol-Others|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GAS2L1 SH3TC2 FHL1 FHL2

2.95e-05184434a63b39fcc570b554cf10e8e47c2c1e079034768f
ToppCellcontrol-Others-Megakaryocytes|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GAS2L1 SH3TC2 FHL1 FHL2

2.95e-05184434213915f2889ce8ecbe5f7b19bc2b24ed8c5efe1d
ToppCelldroplet-Spleen-SPLEEN-1m-Lymphocytic-mature_NK_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTULINL FHL2 CTSD CAP2

2.95e-051844348095be57ed189763b5be039f330149a41e5b406a
ToppCellLV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

FBXO32 TMEM178B FHL1 FHL2

3.01e-051854346baccb26f999145e51b91d94315bf8d4655bef31
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SMARCA1 FHL2 SYNE1 EPB41L2

3.14e-05187434d591a3c216997663ab77710fed0d230ffc37e41a
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SMARCA1 FHL2 SYNE1 EPB41L2

3.14e-05187434d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SMARCA1 FHL2 SYNE1 EPB41L2

3.14e-05187434ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCellRV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

FBXO32 TMEM178B FHL2 CAP2

3.14e-0518743478cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCellHealthy/Control-Platelet|World / Disease group and Cell class

GAS2L1 SH3TC2 FHL1 FHL2

3.21e-05188434552077e4597d0956f4d8c40c9de8f109e87cb857
ToppCellnormal_Lung-Fibroblasts-Smooth_muscle_cells|normal_Lung / Location, Cell class and cell subclass

FHL1 FHL2 FHL5 CAP2

3.21e-05188434fd70fb89570f014d1299c60fe017dc09f24e57c6
ToppCellLV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

FBXO32 TMEM178B FHL2 CAP2

3.21e-051884340758b474457efa36488e0195f7357100f4b6a090
ToppCellHealthy/Control-Platelet|Healthy/Control / Disease group and Cell class

GAS2L1 SH3TC2 FHL1 FHL2

3.27e-051894343de7f8d8b8451ed9a146cce499552e9a060e9099
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

TMEM178B FHL1 FHL2 CAP2

3.27e-051894340a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBXO32 SYNE1 FHL5 CAP2

3.41e-051914347853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

FBXO32 TMEM178B FHL2 CAP2

3.48e-05192434ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBXO32 FHL1 FHL2 CAP2

3.48e-05192434d0fb6885f023d55a2b7984c99db9c6463258f788
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBXO32 FHL1 FHL2 CAP2

3.55e-05193434173f1d83133f5ffa88e2a75d28835ad7acd2aa90
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBXO32 FHL1 FHL2 CAP2

3.55e-05193434a402e736440684ebe123673b6b0c6fcd8fa057b2
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SAMHD1 FHL1 FHL2 EPB41L2

3.55e-0519343409a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SAMHD1 FHL2 FHL5 EPB41L2

3.55e-05193434c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCellE15.5-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBXO32 FHL1 FHL2 SYNE1

3.55e-05193434e787e618f6e8a1e22be366ce606bf78831b60a90
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBXO32 FHL1 FHL2 CAP2

3.55e-05193434b1893193766ae41bf2ab6ed4083285c9c814e608
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SAMHD1 FHL2 FHL5 EPB41L2

3.55e-051934345b602b1702283184bd3943c2a6f2290b7c37e407
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

OTULINL CTSD PIK3CG EPB41L2

3.55e-05193434b52d5661edff83ac4c5fe2bf89d6672016bb827b
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBXO32 FHL1 FHL2 CAP2

3.63e-0519443493bc72a933ccc6a760e5353f072afb606571c6fc
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBXO32 FHL1 FHL2 CAP2

3.63e-05194434bea369e9a7018d862e4d7f1c9ec2de50f3fd38ec
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FBXO32 FHL1 FHL2 CAP2

3.70e-051954344dba732c8d8ecf0ed9ece1814dc4060402199ed9
ToppCelltumor_Lung-Fibroblasts-Smooth_muscle_cells|tumor_Lung / Location, Cell class and cell subclass

FHL1 FHL2 FHL5 CAP2

3.70e-05195434ea9ff25020c2fcd1bab80e1829af0f4e4777de8b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FHL1 FHL2 FHL5 EPB41L2

3.77e-051964341522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SAMHD1 FHL2 FHL5 EPB41L2

3.77e-051964343a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FHL1 FHL2 FHL5 EPB41L2

3.77e-051964341c8294014713684b50885e638668f2ce75f357f0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SAMHD1 FHL2 FHL5 EPB41L2

3.77e-05196434bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBXO32 FHL1 FHL2 CAP2

3.85e-0519743494a7270ea6d4b586f58875c9e4071ce0f683ef7e
ToppCell356C-Fibroblasts-Fibroblast-K_(Pericytes)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FBXO32 FHL1 FHL5 CAP2

3.85e-0519743471367bebc23d0e81f60f780d6b0ab3a1783ac014
ToppCell356C-Fibroblasts-Fibroblast-K_(Pericytes)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FBXO32 FHL1 FHL5 CAP2

3.85e-051974340f9836554ace3f9d155ebafdd719aa26466ca44e
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBXO32 FHL1 SYNE1 FHL5

3.85e-05197434ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCellsystemic_lupus_erythematosus-treated|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SAMHD1 CTSD SYNE1 SMCHD1

3.93e-051984348165ff735095c52994fb5057d89be93cc378b7da
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FBXO32 FHL1 FHL2 CAP2

3.93e-051984342d0c14f8cabab99bc6d7c27685437c78841c7245
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SAMHD1 FHL2 FHL5 EPB41L2

3.93e-0519843479576525a10ed3e3a9d1608077cd16ecda23376f
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SAMHD1 FBXO32 OTULINL FHL1

3.93e-0519843438b37daf41d84e5bf913eb3f72963418b7c0aac6
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBXO32 FHL1 SYNE1 FHL5

3.93e-05198434c12e7511628db819a52959bb68580e27c00c2e41
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FBXO32 FHL2 FHL5 CAP2

3.93e-05198434c9c96066c7fa897b583657f0b77ea093920ae9ba
ToppCell390C-Fibroblasts-Fibroblast-K_(Pericytes)|390C / Donor, Lineage, Cell class and subclass (all cells)

FHL1 FHL2 FHL5 CAP2

3.93e-05198434c82a151f9f1477d4a401457173b8d72af776c137
ToppCell390C-Fibroblasts-Fibroblast-K_(Pericytes)-|390C / Donor, Lineage, Cell class and subclass (all cells)

FHL1 FHL2 FHL5 CAP2

3.93e-05198434dc63b56bb6291e527b172d603569376286262845
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CLEC2D CLK1 SYNE1 SMCHD1

4.00e-05199434f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellmedial-Hematologic-CD4+_Naive_T-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CLEC2D FBXO32 ZNF705EP SMCHD1

4.00e-051994346a896a447388fd525cff207e17a5371c0f6b38cb
ToppCellmedial-2-Hematologic-CD4+_Naive_T|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CLEC2D FBXO32 ZNF705EP SMCHD1

4.00e-05199434231a539899e2b76215da3e96a6755799f722e278
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FBXO32 FHL1 FHL2 SYNE1

4.00e-051994346b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCellmedial-Hematologic-CD4+_Naive_T|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CLEC2D FBXO32 ZNF705EP SMCHD1

4.00e-05199434a54c35a646ae23bdd35c278ffb027408cf8dd553
ToppCell390C-Fibroblasts-Fibroblast-K_(Pericytes)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FHL1 FHL2 FHL5 CAP2

4.08e-052004342bc7f462a551292de2501028164573935232f899
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

FBXO32 FHL1 SYNE1 CAP2

4.08e-05200434c5e051f1aac8dda376c342a9932785a23450e073
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

FBXO32 FHL1 SYNE1 CAP2

4.08e-052004349d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FBXO32 FHL1 FHL2 SYNE1

4.08e-0520043487827041663013f5e7273168dc8709d69840e7ce
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

FBXO32 FHL1 SYNE1 CAP2

4.08e-052004345ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FBXO32 FHL1 SYNE1 CAP2

4.08e-05200434c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SAMHD1 FHL1 SYNE1 EPB41L2

4.08e-05200434b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SAMHD1 FHL1 SYNE1 EPB41L2

4.08e-052004343dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SAMHD1 FHL1 SYNE1 EPB41L2

4.08e-05200434c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FBXO32 FHL1 SYNE1 CAP2

4.08e-05200434dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_3|Control_saline / Treatment groups by lineage, cell group, cell type

SYNE1 FHL5 CAP2 DYRK3

4.08e-05200434b0866b497aa71d06cef25f9a335fa584e95fa7e0
ToppCellLPS_IL1RA-Mesenchymal_myocytic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FBXO32 SYNE1 FHL5 CAP2

4.08e-0520043477631c471cc5d453a749784f838cfa6408caf09b
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SAMHD1 FHL1 SYNE1 EPB41L2

4.08e-052004340c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell390C-Fibroblasts-Fibroblast-K_(Pericytes)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FHL1 FHL2 FHL5 CAP2

4.08e-052004348b80a65b69b36ed405214564b939452c90aa40d6
ToppCellfacs-Skin-Anagen-24m-Epithelial-inner_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC2D SH3TC2 FHL2

1.23e-0410043397ca9cda55a05fbb4d1f5d61f847c965e014f05c
ToppCellRV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

TMEM178B FHL2 ZNF648

2.22e-041224331cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCell3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

CLEC2D SYNE1 SMCHD1

2.99e-04135433ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCellfacs-Liver-Hepatocytes-3m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GCGR BBOX1 SRD5A1

3.25e-0413943382bf5ba69a907fbd9b4e2b2dd1dd27b8c4c75f25
ToppCellfacs-Liver-Hepatocytes-3m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GCGR BBOX1 SRD5A1

3.25e-04139433fc9ac09c2106e88104a52575832d71d17765eec8
ToppCellfacs-Liver-Hepatocytes-3m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GCGR BBOX1 SRD5A1

3.25e-04139433fc4b39ac9a10cf0acacfebbc4295edf324d930d5
ToppCellfacs-Liver-Hepatocytes-3m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GCGR BBOX1 SRD5A1

3.25e-041394334ddfbc36a0560fb70594627178bff652ab1ea3e9
ToppCell(01)_Cycling_Basal_(homeostasis)-(3)_72hpi|(01)_Cycling_Basal_(homeostasis) / shred by cell type and Timepoint

FHL2 LCMT2

3.32e-0428432ef8053df22b28c772eb39c5e4033f96eb5aa54d9
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Tall_Cell-4|TCGA-Thryoid / Sample_Type by Project: Shred V9

SH3TC2 FBXO32 PLRG1

3.46e-0414243343524c10f446c9da079cff52800326a1d4675452
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CLEC2D SYNE1 RNF113A

3.83e-0414743355f4b3289094a1eab6d7a6c8f214ec7b031edfa8
ToppCellsevere_COVID-19-CD8+_T_naive|severe_COVID-19 / disease group, cell group and cell class (v2)

CLEC2D FBXO32 ZNF705EP

4.56e-0415643347aa46cdf5af9834f4b890ac6ce5e8d548ee98db
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CLEC2D FBXO32 SYNE1

4.56e-041564337569cab30caafcb273e8ef0b73c9e1bf87076984
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF860 ZNF705EP ZMYM6

4.73e-04158433ab707bfe782c667b252b488ad1d7efd49cf0a899
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FHL1 FHL2 FHL5

4.82e-04159433cfb4a8c8aac34b1a857956d98382d487abcf5444
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FHL2 SYNE1 EPB41L2

4.82e-041594335ca96db4281abb5f646150ccf36adc66ab201c78
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FHL1 FHL2 FHL5

4.82e-04159433a75ab494959575143cefdaec99e7aee3f318d559
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-11|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF860 SOBP EPB41L2

4.91e-041604338396afbc7d919ba190863d50aa0ef8b9942a9866
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SH3TC2 SAMHD1 EPB41L2

5.00e-041614337d1bc73f4c82465b3f489d6737048b0cd54f22cf
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SH3TC2 SAMHD1 EPB41L2

5.00e-04161433410eef62c83c704cbfc5a1b643c4db11bbdcd81f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SH3TC2 SAMHD1 EPB41L2

5.00e-0416143371022485da6754a2b57b4c3e758e3de4c95cc292
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SH3TC2 SAMHD1 EPB41L2

5.00e-0416143359ae8a7c9a04ecaa335b8064852a5a91a21780bd
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SAMHD1 FHL2 FHL5

5.09e-041624335f009b231f21861afee9cc0c569082e1135f929c
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC2D FBXO32 FHL1

5.09e-04162433bc63a96ad3ba0b3433e3679d7a005f47709ff384
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

CLEC2D CLK1 SMCHD1

5.09e-04162433b4535bcb3f469bc139e73f1122f4070013e5a1de
DiseaseEmery-Dreifuss muscular dystrophy

FHL1 SYNE1

2.68e-056402cv:C0410189
DiseaseMuscular Dystrophy, Emery-Dreifuss

FHL1 SYNE1

2.68e-056402C0410189
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

FHL1 SYNE1

3.75e-057402C0751337
Diseasefat body mass

FHL2 ZNF648 SMCHD1 CAP2

2.11e-04217404EFO_0005409
DiseaseLiver Cirrhosis, Experimental

OTULINL FHL1 FHL2 BBOX1 EPB41L2 SRD5A1

5.73e-04774406C0023893
Diseaseattention deficit hyperactivity disorder (implicated_via_orthology)

FBXO25 FBXO32

6.62e-0428402DOID:1094 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
HEVKEVAGIKFWCYH

CPSF3

141

Q9UKF6
TRKRKYFHHDRLDWD

CLK1

406

P49759
KWCVVFERNYKSHHL

CWF19L1

401

Q69YN2
LKDYKHSDLRHVDWV

CAP2

171

P40123
AKRLWKVCVEHHTFY

EPB41L2

481

O43491
KCWDLEYNKVIRHYH

PLRG1

271

O43660
FLFEKWKLYGDQCHH

GCGR

31

P47871
RHCSILFWKDYHLAL

FBXO25

321

Q8TCJ0
SCKFLHDRSDYKHGW

RNF113A

216

O15541
KAYEELFWRHHIKCV

OTULINL

116

Q9NUU6
SKEVHYKNRFWHDTC

FHL1

51

Q13642
DSKDLCYKDRHWHEG

FHL5

51

Q5TD97
FDCLEWIRKHHPYDS

BLM

876

P54132
WDTLEHYLDKHDPCR

GAS2L1

261

Q99501
KLLDIACWIHHKYNS

CTSD

111

P07339
EHYSEFQADWLKKRC

BBOX1

81

O75936
CKDLSYKDRHWHEAC

FHL2

51

Q14192
WHHAKKDEASGFCYL

HDAC8

141

Q9BY41
EDRLLWKKLCQYHFS

FBXO32

261

Q969P5
ENCKVTYFHRKHWVR

CA5BP1

101

Q8WTZ4
DDYLFIEFLKRCLHW

DYRK3

491

O43781
WDVKRLQTHCYKVHD

NSMCE1

31

Q8WV22
DSHKWEAREKEHYCL

MRPS27

36

Q92552
ICSDHWYETDARKHR

TMEM178B

26

H3BS89
DREFALWLKDCHEKY

SMCHD1

556

A6NHR9
KKFHWRYLVIDEAHR

SMARCA1

301

P28370
HFKEDFDKACHWLKQ

SYNE1

4566

Q8NF91
DKWDYFARDCHHLGI

SAMHD1

311

Q9Y3Z3
EHLLFDHKYWLNCIL

SH3TC2

136

Q8TF17
HKDEEWFRSKYHPDE

SRRT

191

Q9BXP5
HYTERKWICSKSDIH

CLEC2D

176

Q9UHP7
DKELLWHFRYESLKH

PIK3CG

571

P48736
DWCKHIRHTKEYLDF

SOBP

226

A7XYQ1
KYQRCRIWDKLHEEH

STX17

41

P56962
HERTHLGEKWYECDN

ZNF705EP

246

A8MWA4
SWDRHHVDFDLYKKP

nan

531

Q6ZUG5
HKEKVFHTEDDQYCW

ZC3H7A

881

Q8IWR0
KHSDLAKYFHDEEWV

ZMYM6

1096

O95789
HRRWHSREKAYKCDE

ZNF74

266

Q16587
FCDKAYTWSSDHRKH

ZNF648

311

Q5T619
GRAKEHHEWYLRKFE

SRD5A1

231

P18405
LHLTKDFREQKHSYW

GTF3C2

311

Q8WUA4
HWRIHNEERSYKCNK

ZNF860

416

A6NHJ4
FEEWHLKCAHYFILA

LCMT2

296

O60294