Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1C CATSPER1 PKD2L2 ATP2C2 RYR3	9.04e-05	151	60	5	GO:0015085
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1C ANO9 CATSPER1 ATP8A1 PKD2L2 KCNJ1 ATP2C2 SCNN1G RYR3 SLC4A2	1.15e-04	793	60	10	GO:0015075
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA1C ANO9 CATSPER1 ATP8A1 PKD2L2 KCNJ1 ATP2C2 SCNN1G SLCO1B1 ABCA10 RYR3 SLC4A2	1.71e-04	1180	60	12	GO:0022857
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	ANO9 CATSPER1 KCNJ1 SCNN1G RYR3	2.84e-04	193	60	5	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	ANO9 CATSPER1 KCNJ1 SCNN1G RYR3	3.12e-04	197	60	5	GO:0022834
GeneOntologyMolecularFunction	transporter activity	CACNA1C ANO9 CATSPER1 ATP8A1 PKD2L2 KCNJ1 ATP2C2 SCNN1G SLCO1B1 ABCA10 RYR3 SLC4A2	3.86e-04	1289	60	12	GO:0005215
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA1C ANO9 CATSPER1 PKD2L2 KCNJ1 ATP2C2 SCNN1G RYR3 SLC4A2	4.07e-04	758	60	9	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1C ANO9 CATSPER1 PKD2L2 KCNJ1 SCNN1G RYR3	4.37e-04	459	60	7	GO:0005216
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1C CATSPER1 PKD2L2 KCNJ1 ATP2C2 SCNN1G RYR3	4.72e-04	465	60	7	GO:0046873
GeneOntologyMolecularFunction	gated channel activity	CACNA1C ANO9 CATSPER1 KCNJ1 SCNN1G RYR3	4.90e-04	334	60	6	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1C CATSPER1 PKD2L2 KCNJ1 SCNN1G RYR3	5.64e-04	343	60	6	GO:0005261
GeneOntologyMolecularFunction	calcium channel activity	CACNA1C CATSPER1 PKD2L2 RYR3	6.13e-04	129	60	4	GO:0005262
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNA1C CATSPER1 ATP8A1 PKD2L2 KCNJ1 ATP2C2 SCNN1G RYR3	7.97e-04	664	60	8	GO:0008324
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	CATSPER1 KCNJ1 SCNN1G RYR3	8.33e-04	140	60	4	GO:0099094
GeneOntologyMolecularFunction	channel activity	CACNA1C ANO9 CATSPER1 PKD2L2 KCNJ1 SCNN1G RYR3	9.66e-04	525	60	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1C ANO9 CATSPER1 PKD2L2 KCNJ1 SCNN1G RYR3	9.76e-04	526	60	7	GO:0022803
GeneOntologyMolecularFunction	CARD domain binding	NOD1 NOD2	1.17e-03	17	60	2	GO:0050700
GeneOntologyMolecularFunction	peptidoglycan binding	NOD1 NOD2	1.47e-03	19	60	2	GO:0042834
GeneOntologyMolecularFunction	calcium ion binding	FAT1 MICU3 PKD2L2 ACAN PCDHB13 PCDHB8 PCDH17 RYR3	1.72e-03	749	60	8	GO:0005509
GeneOntologyMolecularFunction	cyclase activity	ADCY4 GUCY1B2	2.35e-03	24	60	2	GO:0009975
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	ADCY4 GUCY1B2	2.55e-03	25	60	2	GO:0016849
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNA1C CATSPER1 PKD2L2 KCNJ1 ATP2C2 SCNN1G RYR3	2.66e-03	627	60	7	GO:0022890
GeneOntologyMolecularFunction	lipid transporter activity	ANO9 ATP8A1 SLCO1B1 ABCA10	2.86e-03	196	60	4	GO:0005319
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ATP8A1 ATP2C2 ABCA10	4.32e-03	109	60	3	GO:0042626
GeneOntologyBiologicalProcess	cellular response to nitrogen compound	RAB10 FAT1 NOD1 CYP11A1 SCNN1G RIOK3 PRKDC RYR3 HTT NOD2	4.87e-05	752	59	10	GO:1901699
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	CACNA1C ANO9 MICU3 CATSPER1 ATP8A1 PKD2L2 KCNJ1 ATP2C2 SCNN1G RYR3 HTT SLC4A2	6.20e-05	1115	59	12	GO:0034220
GeneOntologyBiologicalProcess	monoatomic ion transport	CACNA1C ANO9 MICU3 CATSPER1 ATP8A1 PKD2L2 KCNJ1 ATP2C2 SCNN1G SLCO1B1 RYR3 HTT SLC4A2	1.09e-04	1374	59	13	GO:0006811
GeneOntologyBiologicalProcess	calcium ion transmembrane transport	CACNA1C MICU3 CATSPER1 PKD2L2 ATP2C2 RYR3 HTT	1.24e-04	392	59	7	GO:0070588
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	CACNA1C ANO9 MICU3 CATSPER1 PKD2L2 KCNJ1 ATP2C2 SCNN1G RYR3 HTT SLC4A2	1.26e-04	1017	59	11	GO:0098660
GeneOntologyBiologicalProcess	positive regulation of dendritic cell antigen processing and presentation	NOD1 NOD2	1.67e-04	7	59	2	GO:0002606
GeneOntologyBiologicalProcess	positive regulation of adenylate cyclase activity	CACNA1C ADCY4 RXFP2	2.04e-04	40	59	3	GO:0045762
GeneOntologyBiologicalProcess	cellular response to magnesium ion	KCNJ1 RYR3	2.23e-04	8	59	2	GO:0071286
GeneOntologyBiologicalProcess	cellular response to muramyl dipeptide	NOD1 NOD2	2.86e-04	9	59	2	GO:0071225
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	CACNA1C MICU3 CATSPER1 ATP8A1 PKD2L2 KCNJ1 ATP2C2 SCNN1G RYR3 HTT	3.08e-04	942	59	10	GO:0098655
GeneOntologyBiologicalProcess	intracellular monoatomic cation homeostasis	CACNA1C MICU3 ATP2C2 EIF3E SCNN1G RYR3 HTT SLC4A2	3.32e-04	611	59	8	GO:0030003
GeneOntologyBiologicalProcess	positive regulation of cyclase activity	CACNA1C ADCY4 RXFP2	3.51e-04	48	59	3	GO:0031281
GeneOntologyBiologicalProcess	regulation of xenophagy	NOD1 NOD2	3.57e-04	10	59	2	GO:1904415
GeneOntologyBiologicalProcess	positive regulation of xenophagy	NOD1 NOD2	3.57e-04	10	59	2	GO:1904417
GeneOntologyBiologicalProcess	positive regulation of lyase activity	CACNA1C ADCY4 RXFP2	3.73e-04	49	59	3	GO:0051349
GeneOntologyBiologicalProcess	intracellular monoatomic ion homeostasis	CACNA1C MICU3 ATP2C2 EIF3E SCNN1G RYR3 HTT SLC4A2	3.74e-04	622	59	8	GO:0006873
GeneOntologyCellularComponent	calcium channel complex	CACNA1C MICU3 CATSPER1 RYR3	5.03e-05	73	58	4	GO:0034704
GeneOntologyCellularComponent	basal plasma membrane	NOD1 ATP2C2 ITGA9 SLCO1B1 SLC4A2 NOD2	4.36e-04	354	58	6	GO:0009925
GeneOntologyCellularComponent	cation channel complex	CACNA1C MICU3 CATSPER1 SCNN1G RYR3	4.85e-04	235	58	5	GO:0034703
GeneOntologyCellularComponent	basal part of cell	NOD1 ATP2C2 ITGA9 SLCO1B1 SLC4A2 NOD2	6.15e-04	378	58	6	GO:0045178
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNA1C MICU3 CATSPER1 KCNJ1 SCNN1G RYR3	6.15e-04	378	58	6	GO:0034702
GeneOntologyCellularComponent	transporter complex	CACNA1C MICU3 CATSPER1 ATP8A1 KCNJ1 SCNN1G RYR3	7.91e-04	550	58	7	GO:1990351
Domain	ARM-type_fold	PPP2R5E DIAPH2 HEATR1 PRKDC STAG3 RYR3 HTT	7.40e-05	339	57	7	IPR016024
Domain	Cadherin_CS	FAT1 PCDHB13 PCDHB8 PCDH17	3.42e-04	109	57	4	IPR020894
Domain	CADHERIN_1	FAT1 PCDHB13 PCDHB8 PCDH17	3.92e-04	113	57	4	PS00232
Domain	Cadherin	FAT1 PCDHB13 PCDHB8 PCDH17	3.92e-04	113	57	4	PF00028
Domain	CADHERIN_2	FAT1 PCDHB13 PCDHB8 PCDH17	4.05e-04	114	57	4	PS50268
Domain	-	FAT1 PCDHB13 PCDHB8 PCDH17	4.05e-04	114	57	4	2.60.40.60
Domain	CA	FAT1 PCDHB13 PCDHB8 PCDH17	4.19e-04	115	57	4	SM00112
Domain	HEAT	HEATR1 PRKDC HTT	4.23e-04	48	57	3	PF02985
Domain	Cadherin-like	FAT1 PCDHB13 PCDHB8 PCDH17	4.33e-04	116	57	4	IPR015919
Domain	Cadherin	FAT1 PCDHB13 PCDHB8 PCDH17	4.62e-04	118	57	4	IPR002126
Domain	-	PPP2R5E HEATR1 PRKDC STAG3 HTT	5.74e-04	222	57	5	1.25.10.10
Domain	CRAL_TRIO_2	PRUNE2 MCF2L	5.92e-04	12	57	2	PF13716
Domain	HEAT	HEATR1 PRKDC HTT	7.38e-04	58	57	3	IPR000357
Domain	FH2	DIAPH2 FMN2	9.37e-04	15	57	2	PS51444
Domain	FH2_Formin	DIAPH2 FMN2	9.37e-04	15	57	2	IPR015425
Domain	FH2	DIAPH2 FMN2	9.37e-04	15	57	2	PF02181
Domain	FH2	DIAPH2 FMN2	9.37e-04	15	57	2	SM00498
Domain	Cadherin_2	PCDHB13 PCDHB8 PCDH17	1.03e-03	65	57	3	PF08266
Domain	Cadherin_N	PCDHB13 PCDHB8 PCDH17	1.03e-03	65	57	3	IPR013164
Domain	HEAT_REPEAT	HEATR1 PRKDC HTT	1.28e-03	70	57	3	PS50077
Domain	ARM-like	PPP2R5E HEATR1 PRKDC STAG3 HTT	1.38e-03	270	57	5	IPR011989
Domain	GUANYLATE_CYCLASE_1	ADCY4 GUCY1B2	1.51e-03	19	57	2	PS00452
Domain	Guanylate_cyc	ADCY4 GUCY1B2	1.51e-03	19	57	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY4 GUCY1B2	1.51e-03	19	57	2	PS50125
Domain	A/G_cyclase	ADCY4 GUCY1B2	1.51e-03	19	57	2	IPR001054
Domain	CYCc	ADCY4 GUCY1B2	1.51e-03	19	57	2	SM00044
Domain	Pentatricopeptide_repeat	PRKDC HTT	2.22e-03	23	57	2	IPR002885
Domain	NACHT	NOD1 NOD2	2.22e-03	23	57	2	PS50837
Domain	NACHT_NTPase	NOD1 NOD2	2.22e-03	23	57	2	IPR007111
Domain	SEC14	PRUNE2 MCF2L	2.62e-03	25	57	2	SM00516
Domain	CRAL_TRIO	PRUNE2 MCF2L	3.06e-03	27	57	2	PS50191
Domain	CARD	NOD1 NOD2	3.29e-03	28	57	2	PF00619
Domain	CRAL-TRIO_dom	PRUNE2 MCF2L	3.29e-03	28	57	2	IPR001251
Domain	P-loop_NTPase	RAB10 GUF1 NOD1 INO80 HS6ST3 ABCA10 DNAH1 NOD2	4.02e-03	848	57	8	IPR027417
Domain	CARD	NOD1 NOD2	4.02e-03	31	57	2	IPR001315
Domain	CARD	NOD1 NOD2	4.55e-03	33	57	2	PS50209
Domain	Ion_trans_dom	CACNA1C CATSPER1 RYR3	5.10e-03	114	57	3	IPR005821
Domain	Ion_trans	CACNA1C CATSPER1 RYR3	5.10e-03	114	57	3	PF00520
Domain	ATPase_P-typ_cyto_domN	ATP8A1 ATP2C2	5.10e-03	35	57	2	IPR023299
Domain	P_typ_ATPase	ATP8A1 ATP2C2	5.39e-03	36	57	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP8A1 ATP2C2	5.39e-03	36	57	2	IPR018303
Domain	ATPASE_E1_E2	ATP8A1 ATP2C2	5.39e-03	36	57	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP8A1 ATP2C2	5.69e-03	37	57	2	IPR008250
Domain	E1-E2_ATPase	ATP8A1 ATP2C2	5.69e-03	37	57	2	PF00122
Pubmed	A unique role of cohesin-SA1 in gene regulation and development.	PCDHB13 PCDHB8 PCDH17	2.83e-06	16	61	3	22415368
Pubmed	Synergism between TLRs and NOD1/2 in oral epithelial cells.	NOD1 NOD2	3.03e-06	2	61	2	18573991
Pubmed	Signalling pathways and molecular interactions of NOD1 and NOD2.	NOD1 NOD2	3.03e-06	2	61	2	16493424
Pubmed	Mutational analysis of human NOD1 and NOD2 NACHT domains reveals different modes of activation.	NOD1 NOD2	3.03e-06	2	61	2	21310790
Pubmed	Inflammatory cytokine response to Bacillus anthracis peptidoglycan requires phagocytosis and lysosomal trafficking.	NOD1 NOD2	3.03e-06	2	61	2	20308305
Pubmed	NOD1 and NOD2 regulate proinflammatory and prolabor mediators in human fetal membranes and myometrium via nuclear factor-kappa B.	NOD1 NOD2	3.03e-06	2	61	2	23740944
Pubmed	NOD1 and NOD2 of the innate immune system is differently expressed in human clear cell renal cell carcinoma, corresponding healthy renal tissue, its vasculature and primary isolated renal tubular epithelial cells.	NOD1 NOD2	3.03e-06	2	61	2	30903318
Pubmed	Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.	NOD1 NOD2	3.03e-06	2	61	2	12871942
Pubmed	Role of Nod1 in mucosal dendritic cells during Salmonella pathogenicity island 1-independent Salmonella enterica serovar Typhimurium infection.	NOD1 NOD2	3.03e-06	2	61	2	19620349
Pubmed	Nucleotide oligomerization domains 1 and 2: regulation of expression and function in preadipocytes.	NOD1 NOD2	3.03e-06	2	61	2	18714036
Pubmed	NOD1 and NOD2 signalling links ER stress with inflammation.	NOD1 NOD2	3.03e-06	2	61	2	27007849
Pubmed	A Salmonella virulence factor activates the NOD1/NOD2 signaling pathway.	NOD1 NOD2	3.03e-06	2	61	2	22186610
Pubmed	Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections.	NOD1 NOD2	3.03e-06	2	61	2	21669398
Pubmed	Understanding the molecular differential recognition of muramyl peptide ligands by LRR domains of human NOD receptors.	NOD1 NOD2	3.03e-06	2	61	2	28673961
Pubmed	Implication of NOD1 and NOD2 for the differentiation of multipotent mesenchymal stem cells derived from human umbilical cord blood.	NOD1 NOD2	3.03e-06	2	61	2	21042538
Pubmed	LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition.	NOD1 NOD2	3.03e-06	2	61	2	29211798
Pubmed	Aggregatibacter actinomycetemcomitans outer membrane vesicles are internalized in human host cells and trigger NOD1- and NOD2-dependent NF-κB activation.	NOD1 NOD2	3.03e-06	2	61	2	25024364
Pubmed	The role of NOD1/CARD4 and NOD2/CARD15 genetic variations in lung cancer risk.	NOD1 NOD2	3.03e-06	2	61	2	26238283
Pubmed	Contribution of the NOD1/CARD4 insertion/deletion polymorphism +32656 to inflammatory bowel disease in Northern Europe.	NOD1 NOD2	3.03e-06	2	61	2	17285593
Pubmed	Function of Nod-like receptors in microbial recognition and host defense.	NOD1 NOD2	3.03e-06	2	61	2	19120480
Pubmed	Cross-tolerization between Nod1 and Nod2 signaling results in reduced refractoriness to bacterial infection in Nod2-deficient macrophages.	NOD1 NOD2	3.03e-06	2	61	2	18768892
Pubmed	Expression and in vitro assessment of tumorigenicity for NOD1 and NOD2 receptors in breast cancer cell lines.	NOD1 NOD2	3.03e-06	2	61	2	29615116
Pubmed	NOD-like receptor activation by outer membrane vesicles from Vibrio cholerae non-O1 non-O139 strains is modulated by the quorum-sensing regulator HapR.	NOD1 NOD2	3.03e-06	2	61	2	21263023
Pubmed	Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography.	CACNA1C RYR3	3.03e-06	2	61	2	24026422
Pubmed	Simultaneous deletion of NOD1 and NOD2 inhibits in vitro alloresponses but does not prevent allograft rejection.	NOD1 NOD2	3.03e-06	2	61	2	26159289
Pubmed	The role of nucleotide-binding oligomerization domain 1 during cytokine production by macrophages in response to Mycobacterium tuberculosis infection.	NOD1 NOD2	3.03e-06	2	61	2	26255090
Pubmed	Endosomes as platforms for NOD-like receptor signaling.	NOD1 NOD2	3.03e-06	2	61	2	24832447
Pubmed	The effects of NOD activation on adipocyte differentiation.	NOD1 NOD2	3.03e-06	2	61	2	23712977
Pubmed	Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis.	NOD1 NOD2	3.03e-06	2	61	2	18574154
Pubmed	Gene Variants, mRNA and NOD1/2 Protein Levels in Tunisian Childhood Asthma.	NOD1 NOD2	3.03e-06	2	61	2	30874883
Pubmed	Association of Nucleotide-binding Oligomerization Domain Receptors with Peptic Ulcer and Gastric Cancer.	NOD1 NOD2	3.03e-06	2	61	2	27917621
Pubmed	The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists.	NOD1 NOD2	3.03e-06	2	61	2	16115863
Pubmed	Differential expression and regulation of nuclear oligomerization domain proteins NOD1 and NOD2 in human endometrium: a potential role in innate immune protection and menstruation.	NOD1 NOD2	3.03e-06	2	61	2	19273470
Pubmed	Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology.	NOD1 NOD2	3.03e-06	2	61	2	21745515
Pubmed	Influence of a nucleotide oligomerization domain 1 (NOD1) polymorphism and NOD2 mutant alleles on Crohn's disease phenotype.	NOD1 NOD2	3.03e-06	2	61	2	17907287
Pubmed	Activation of Nod1 and Nod2 induces innate immune responses of prostate epithelial cells.	NOD1 NOD2	3.03e-06	2	61	2	22228081
Pubmed	NOD1/NOD2-mediated recognition of non-typeable Haemophilus influenzae activates innate immunity during otitis media.	NOD1 NOD2	3.03e-06	2	61	2	31474163
Pubmed	NOD1 and NOD2 in inflammatory and infectious diseases.	NOD1 NOD2	3.03e-06	2	61	2	32677123
Pubmed	NOD1 and NOD2 expression and function in very preterm infant mononuclear cells.	NOD1 NOD2	3.03e-06	2	61	2	24444388
Pubmed	Analgesic effects of chemically synthesized NOD1 and NOD2 agonists in mice.	NOD1 NOD2	3.03e-06	2	61	2	20083500
Pubmed	NOD1 and NOD2 stimulation triggers innate immune responses of human periodontal ligament cells.	NOD1 NOD2	3.03e-06	2	61	2	22218461
Pubmed	Nucleotide-binding oligomerization domain (NOD) plays an important role in neonatal infection.	NOD1 NOD2	3.03e-06	2	61	2	30321637
Pubmed	Complex insertion/deletion polymorphism in NOD1 (CARD4) is not associated with inflammatory bowel disease susceptibility in East Anglia panel.	NOD1 NOD2	3.03e-06	2	61	2	17012967
Pubmed	Salmonella enterica serovar Typhimurium ΔmsbB triggers exacerbated inflammation in Nod2 deficient mice.	NOD1 NOD2	3.03e-06	2	61	2	25423082
Pubmed	Higher Expression of NOD1 and NOD2 is Associated with Vogt-Koyanagi-Harada (VKH) Syndrome But Not Behcet's Disease (BD).	NOD1 NOD2	3.03e-06	2	61	2	26980698
Pubmed	Identification of microRNAs involved in NOD-dependent induction of pro-inflammatory genes in pulmonary endothelial cells.	NOD1 NOD2	3.03e-06	2	61	2	32353008
Pubmed	Nod1 and Nod2 enhance TLR-mediated invariant NKT cell activation during bacterial infection.	NOD1 NOD2	3.03e-06	2	61	2	24163408
Pubmed	NOD1 and NOD2 control the invasiveness of trophoblast cells via the MAPK/p38 signaling pathway in human first-trimester pregnancy.	NOD1 NOD2	3.03e-06	2	61	2	25840495
Pubmed	Disruption of Nod-like receptors alters inflammatory response to infection but does not confer protection in experimental cerebral malaria.	NOD1 NOD2	3.03e-06	2	61	2	19407112
Pubmed	Association of NOD1 and NOD2 genes polymorphisms with Helicobacter pylori related gastric cancer in a Chinese population.	NOD1 NOD2	3.03e-06	2	61	2	22563200
Pubmed	NOD protein expression and function in first trimester trophoblast cells.	NOD1 NOD2	3.03e-06	2	61	2	17156193
Pubmed	Nod-like receptors are critical for gut-brain axis signalling in mice.	NOD1 NOD2	3.03e-06	2	61	2	31652348
Pubmed	Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis.	NOD1 NOD2	3.03e-06	2	61	2	27799160
Pubmed	Association of NOD1 and NOD2 polymorphisms with Guillain-Barré syndrome in Northern Indian population.	NOD1 NOD2	3.03e-06	2	61	2	27000222
Pubmed	Nucleotide-binding oligomerization domain-1 and -2 play no role in controlling Brucella abortus infection in mice.	NOD1 NOD2	3.03e-06	2	61	2	22203860
Pubmed	Investigation of NOD1/CARD4 variation in inflammatory bowel disease using a haplotype-tagging strategy.	NOD1 NOD2	3.03e-06	2	61	2	17613538
Pubmed	NOD1 and NOD2 Genetic Variants in Association with Risk of Gastric Cancer and Its Precursors in a Chinese Population.	NOD1 NOD2	3.03e-06	2	61	2	25933107
Pubmed	Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancer.	NOD1 NOD2	3.03e-06	2	61	2	35130902
Pubmed	Effects of genetic variations in the genes encoding NOD1 and NOD2 on type 2 diabetes mellitus and insulin resistance.	NOD1 NOD2	3.03e-06	2	61	2	27885704
Pubmed	NOD1 and NOD2 regulation of pulmonary innate immunity to Legionella pneumophila.	NOD1 NOD2	3.03e-06	2	61	2	21108472
Pubmed	Convergence of innate immunity and insulin resistance as evidenced by increased nucleotide oligomerization domain (NOD) expression and signaling in monocytes from patients with type 2 diabetes.	NOD1 NOD2	3.03e-06	2	61	2	24018334
Pubmed	Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors.	NOD1 NOD2	3.03e-06	2	61	2	20844241
Pubmed	NOD1 and NOD2 receptors: integral members of the innate and adaptive immunity system.	NOD1 NOD2	3.03e-06	2	61	2	23901396
Pubmed	Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen.	NOD1 NOD2	3.03e-06	2	61	2	21411735
Pubmed	Lack of Both Nucleotide-Binding Oligomerization Domain-Containing Proteins 1 and 2 Primes T Cells for Activation-Induced Cell Death.	NOD1 NOD2	3.03e-06	2	61	2	28652394
Pubmed	Phenotyping of Nod1/2 double deficient mice and characterization of Nod1/2 in systemic inflammation and associated renal disease.	NOD1 NOD2	3.03e-06	2	61	2	23259058
Pubmed	Association of NOD1 and NOD2 Polymorphisms With Susceptibility to Subacute Sclerosing Panencephalitis.	NOD1 NOD2	3.03e-06	2	61	2	36544356
Pubmed	Nod1 and nod2 are expressed in human and murine renal tubular epithelial cells and participate in renal ischemia reperfusion injury.	NOD1 NOD2	3.03e-06	2	61	2	20124104
Pubmed	Immunohistochemical detection of NOD1 and NOD2 in the healthy murine and canine eye.	NOD1 NOD2	3.03e-06	2	61	2	19604345
Pubmed	NOD1 activators link innate immunity to insulin resistance.	NOD1 NOD2	3.03e-06	2	61	2	21715553
Pubmed	Variants of NOD1 and NOD2 genes display opposite associations with familial risk of Crohn's disease and anti-saccharomyces cerevisiae antibody levels.	NOD1 NOD2	3.03e-06	2	61	2	21739538
Pubmed	Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators.	NOD1 NOD2	3.03e-06	2	61	2	25093298
Pubmed	Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate.	NOD1 NOD2	3.03e-06	2	61	2	33942347
Pubmed	Genetic variation in NOD1/CARD4 and NOD2/CARD15 immune sensors and risk of osteoporosis.	NOD1 NOD2	3.03e-06	2	61	2	32578848
Pubmed	Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae.	NOD1 NOD2	3.03e-06	2	61	2	15653568
Pubmed	Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms.	NOD1 NOD2	3.03e-06	2	61	2	23888881
Pubmed	Induction of Nod1 and Nod2 intracellular pattern recognition receptors in murine osteoblasts following bacterial challenge.	NOD1 NOD2	3.03e-06	2	61	2	15845503
Pubmed	Activation of NOD1 and NOD2 in the development of liver injury and cancer.	NOD1 NOD2	3.03e-06	2	61	2	36268029
Pubmed	Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.	PCDHB13 PCDHB8 PCDH17	4.88e-06	19	61	3	23920377
Pubmed	Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model.	NOD1 NOD2	9.07e-06	3	61	2	20921147
Pubmed	Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines.	NOD1 NOD2	9.07e-06	3	61	2	17403538
Pubmed	Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.	NOD1 NOD2	9.07e-06	3	61	2	19898471
Pubmed	Molecular mechanisms regulating the synergism between IL-32γ and NOD for the activation of eosinophils.	NOD1 NOD2	9.07e-06	3	61	2	24295830
Pubmed	Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells.	NOD1 NOD2	9.07e-06	3	61	2	27624090
Pubmed	Synergistic effects of NOD1 or NOD2 and TLR4 activation on mouse sickness behavior in relation to immune and brain activity markers.	NOD1 NOD2	9.07e-06	3	61	2	25218901
Pubmed	Activation of host mitogen-activated protein kinases by secreted Legionella pneumophila effectors that inhibit host protein translation.	NOD1 NOD2	9.07e-06	3	61	2	22851749
Pubmed	The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration.	NOD1 NOD2	9.07e-06	3	61	2	24882705
Pubmed	The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila.	NOD1 NOD2	9.07e-06	3	61	2	20685341
Pubmed	Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia.	MTHFR SLCO1B1	9.07e-06	3	61	2	23652803
Pubmed	NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis.	NOD1 NOD2	9.07e-06	3	61	2	16322770
Pubmed	NOD1/NOD2 and RIP2 Regulate Endoplasmic Reticulum Stress-Induced Inflammation during Chlamydia Infection.	NOD1 NOD2	9.07e-06	3	61	2	32487756
Pubmed	Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to Salmonella enterica serovar Typhimurium infection in vivo.	NOD1 NOD2	9.07e-06	3	61	2	22615249
Pubmed	Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis.	NOD1 NOD2	9.07e-06	3	61	2	26989200
Pubmed	NOD2/CARD15, NOD1/CARD4, and ICAM-1 gene polymorphisms in Turkish patients with inflammatory bowel disease.	NOD1 NOD2	9.07e-06	3	61	2	16741608
Pubmed	Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo.	NOD1 NOD2	9.07e-06	3	61	2	20008287
Pubmed	Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades.	ITGA9 PROX1	9.07e-06	3	61	2	17287396
Pubmed	A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.	NOD1 NOD2	9.07e-06	3	61	2	23711367
Pubmed	Nod1, Nod2 and Nalp3 receptors, new potential targets in treatment of allergic rhinitis?	NOD1 NOD2	9.07e-06	3	61	2	20384614
Pubmed	Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer.	NOD1 NOD2	9.07e-06	3	61	2	19843337
Pubmed	The kinase activity of Rip2 determines its stability and consequently Nod1- and Nod2-mediated immune responses.	NOD1 NOD2	9.07e-06	3	61	2	19473975
Cytoband	5q31	PKD2L2 PCDHB13 PCDHB8	4.96e-04	115	61	3	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	CDAN1 EIF2AK4 INO80	1.01e-03	147	61	3	chr15q15
Cytoband	3p21.1	COL7A1 DNAH1	1.44e-03	42	61	2	3p21.1
Cytoband	15q15.1	EIF2AK4 INO80	1.81e-03	47	61	2	15q15.1
Cytoband	1q43	FMN2 HEATR1	2.12e-03	51	61	2	1q43
Cytoband	Ensembl 112 genes in cytogenetic band chr1q43	FMN2 HEATR1	3.12e-03	62	61	2	chr1q43
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRUNE2 CACNA1C FAT1 ITGA9 RYR3	5.94e-06	188	61	5	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	PRUNE2 CACNA1C FAT1 ITGA9 RYR3	6.26e-06	190	61	5	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT1 SERPINB13 ATP2C2 FER1L6-AS2 SCNN1G	7.10e-06	195	61	5	e7230a849ea31e6eef9bc6f5468938499450582d
ToppCell	(08)_PNEC\|World / shred by cell type and Timepoint	PRUNE2 ATP8A1 KCNJ1 MCF2L PROX1	7.28e-06	196	61	5	2ee37155c03cd5009427a4bffe6c80ed2ac6939e
ToppCell	Sigmoid-B_cell-B_cell_IgG_Plasma\|B_cell / Region, Cell class and subclass	COL7A1 OR2AP1 EIF2AK4 ITGA9 RYR3	7.64e-06	198	61	5	305d7ae9b070ac7211638a5282374c02bf13af40
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic-T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO9 MTHFR DIAPH2 CEP43	4.32e-05	142	61	4	58c2882cb0ede8cc5d84c85a650d28267268e748
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADCY4 HLA-DMA MCF2L PCDH17	5.48e-05	151	61	4	3b4c57bad61e17a573e6f8dc6b917fba5fd56c43
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FAT1 ITGA9 PCDH17 PROX1	6.38e-05	157	61	4	516903469756c5fabfdf56d7bd59b3bdd7b44e39
ToppCell	COVID-19-kidney-Epithelial_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1C ADCY4 ITGA9 PCDH17	6.86e-05	160	61	4	0d4880f85565d8c540c94a8f8109147b3029279a
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PKD2L2 MCF2L ABCA10 PROX1	7.73e-05	165	61	4	3d2acdae0dd2b79a15f74158e8e566ce22b4218e
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT1 ATP2C2 FER1L6-AS2 PCDH17	8.48e-05	169	61	4	bddb28a8b9afbe4a68f082e82caf96a6666fc674
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT1 ATP2C2 FER1L6-AS2 PCDH17	8.48e-05	169	61	4	5ce46bac8e767feec7ecdc61689de225c49bd3f7
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8A1 KCNJ1 ABCA10 PROX1	9.29e-05	173	61	4	0c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Lymphatic_ECs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	ADCY4 ITGA9 PCDH17 PROX1	9.50e-05	174	61	4	d551bc29afef071adf4c9bb80345352ec33441d8
ToppCell	368C-Endothelial_cells-Endothelial-D\|368C / Donor, Lineage, Cell class and subclass (all cells)	ADCY4 MCF2L PCDH17 RYR3	9.71e-05	175	61	4	c4088b5f9fa145869cf5dd8bee7680b1c8fada42
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_MYBPHL\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT1 ATP2C2 FER1L6-AS2 PCDH17	9.71e-05	175	61	4	bc6bd8c3ce956245ef4db91af9501649d5c09478
ToppCell	368C-Endothelial_cells-Endothelial-D-\|368C / Donor, Lineage, Cell class and subclass (all cells)	ADCY4 MCF2L PCDH17 RYR3	9.71e-05	175	61	4	ca0d3e3a0a271cccdd3881b055fecb626712478d
ToppCell	P15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PRUNE2 ITGA9 RYR3 PROX1	9.71e-05	175	61	4	84d252f3e432231687613299bbea14978bb4b06b
ToppCell	P15-Endothelial-lymphatic_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PRUNE2 ITGA9 RYR3 PROX1	9.71e-05	175	61	4	a00c6fa9b33640710dd05a3799031147196f0986
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122\|Adult / Lineage, Cell type, age group and donor	FAT1 ATP8A1 CYP11A1 ITGA9	9.92e-05	176	61	4	3fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell	wk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ATP8A1 CYP11A1 HS6ST3 PCDH17	1.01e-04	177	61	4	15a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 SCNN1G ITGA9 PROX1	1.04e-04	178	61	4	4ef6344d0ffc9c55b1240bee94b741382f1427bb
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 SCNN1G ITGA9 PROX1	1.04e-04	178	61	4	c65932cbedbbfacb6f0299280663fe7c88dba72b
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL7A1 SCNN1G ITGA9 PCDH17	1.04e-04	178	61	4	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ATP2C2 RXFP2 PCDH17 RYR3	1.06e-04	179	61	4	f65889bf1e41396979cce44a5e63f49dea2bbd9b
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRUNE2 FAT1 ITGA9 RYR3	1.11e-04	181	61	4	25915e2500430a902db37d79a749ce2990b69810
ToppCell	Control-Epithelial-Basal\|World / Disease state, Lineage and Cell class	COL7A1 FAT1 SERPINB13 SCNN1G	1.13e-04	182	61	4	759390dde9b18757f7675d13d44c89d0e32f8d93
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 ATP2C2 MCF2L SLCO1B1	1.13e-04	182	61	4	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	Control-Epithelial-Basal\|Control / Disease state, Lineage and Cell class	COL7A1 FAT1 SERPINB13 SCNN1G	1.13e-04	182	61	4	caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO9 ADCY4 ITGA9 PROX1	1.13e-04	182	61	4	f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCell	COVID-19-kidney-Mito-rich_EC\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1C ADCY4 ITGA9 PCDH17	1.15e-04	183	61	4	3c4153479fc4ab2d073d92cee120480015555914
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ATP2C2 RXFP2 PCDH17 RYR3	1.15e-04	183	61	4	65f2a5895d166189a095cf7ea9dda171f0419b08
ToppCell	COVID-19-Heart-EC_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C ADCY4 MCF2L ITGA9	1.15e-04	183	61	4	ff95382cfed592190d0636d2b750328471f82e0d
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT1 ATP8A1 ITGA9 PCDH17	1.18e-04	184	61	4	102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	FAT1 ATP8A1 CYP11A1 ITGA9	1.20e-04	185	61	4	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	Mild_COVID-19-Epithelial-AT1/AT2\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FAT1 SCNN1G MCF2L PCDH17	1.20e-04	185	61	4	c55fdba1e3818ec0404d7ab473bf18dd25f2bb0a
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP8A1 NOXA1 SCNN1G ITGA9	1.23e-04	186	61	4	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRUNE2 FMN2 MCF2L PROX1	1.23e-04	186	61	4	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D175\|Adult / Lineage, Cell type, age group and donor	ADCY4 FAT1 MCF2L PCDH17	1.25e-04	187	61	4	f3548817f2fded5978137bb252cb628ac199e4f6
ToppCell	COVID-19-lung-Artery_EC\|lung / Disease (COVID-19 only), tissue and cell type	ADCY4 MCF2L ITGA9 PCDH17	1.28e-04	188	61	4	eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADCY4 MCF2L ITGA9 PROX1	1.31e-04	189	61	4	0d18ea72bd58d32a8ab9a61cf97f5786642f804b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8A1 KCNJ1 ABCA10 PROX1	1.31e-04	189	61	4	977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADCY4 MCF2L PCDH17 NOD2	1.33e-04	190	61	4	2655df8c0883dd811fa7617301f9c4b0a4dd55ec
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8A1 KCNJ1 ABCA10 PROX1	1.33e-04	190	61	4	e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADCY4 MCF2L PCDH17 PROX1	1.36e-04	191	61	4	79b399496bd7322a1d53c43378f48695fd09a5d9
ToppCell	facs-Trachea-24m-Endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADCY4 MCF2L PCDH17 PROX1	1.36e-04	191	61	4	9c6d5d045781c6506ae80e318427ef1e0d87f45c
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADCY4 MCF2L PCDH17 PROX1	1.36e-04	191	61	4	1b1e943709d0c3283a980c7c965ef1f110506a29
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRUNE2 CACNA1C FAT1 ACAN	1.36e-04	191	61	4	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 MCF2L SLCO1B1 RYR3	1.39e-04	192	61	4	eafead22bba48ac5ee568faa8946c444445c1034
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C ADCY4 MCF2L ITGA9	1.39e-04	192	61	4	27ff3621e177e7932dd44dd6baa81551ea75a874
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ITGA9 PCDH17 RYR3	1.39e-04	192	61	4	1ee4783051ec94ea94600f040edcb385fc4289f1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ITGA9 PCDH17 RYR3	1.39e-04	192	61	4	25cb6cc6cbf8dc20139d938adfc02ed7a8c3dfb6
ToppCell	343B-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HEATR1 EZH1 HTT SLC4A2	1.39e-04	192	61	4	445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCell	facs-MAT-Fat-3m-Endothelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MCF2L PCDH17 PROX1	1.41e-04	193	61	4	b32533afeff1905e188becaa09079e9699722e4b
ToppCell	facs-MAT-Fat-3m-Endothelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MCF2L PCDH17 PROX1	1.41e-04	193	61	4	2ff573ba2c74583ed1cb071a3bbc01bb71117e5f
ToppCell	facs-MAT-Fat-3m-Endothelial-endothelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MCF2L PCDH17 PROX1	1.41e-04	193	61	4	e164f6403a8b541ced08a6feec915d2e855036ea
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 MCF2L PCDH17 RYR3	1.41e-04	193	61	4	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	Adult-Endothelial\|Adult / Lineage, Cell type, age group and donor	ADCY4 MCF2L PCDH17 PROX1	1.44e-04	194	61	4	963b3fbee0575af8379baa397ace65949eaf34f7
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1C ADCY4 MCF2L PCDH17	1.47e-04	195	61	4	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_venous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADCY4 MCF2L PCDH17 RYR3	1.47e-04	195	61	4	fde8e7b38b3631109b95ef111c5f6e3f9878cfbd
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT1 NOD1 SCNN1G ITGA9	1.50e-04	196	61	4	ed76eeb37400ca154feae9b7ebaddb6c434f8b81
ToppCell	facs-GAT-Fat-3m-Endothelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MCF2L PCDH17 PROX1	1.50e-04	196	61	4	b6cc1f466d45479764080d34b1daeb8243a5a9f3
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1C ADCY4 ITGA9 PCDH17	1.50e-04	196	61	4	ac2c4a325efa8497a755cd31fb6a9d94d8e3bf42
ToppCell	facs-GAT-Fat-3m-Endothelial-endothelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MCF2L PCDH17 PROX1	1.50e-04	196	61	4	ede6104cdfa4ee5287efcca9bbc36677cbf7a8d8
ToppCell	facs-GAT-Fat-3m-Endothelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MCF2L PCDH17 PROX1	1.50e-04	196	61	4	039044ab28c53391c34d8226fb8cf78549e63ef4
ToppCell	Basal_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	COL7A1 FAT1 SERPINB13 UGT1A7	1.50e-04	196	61	4	3b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ITGA9 PCDH17 RYR3	1.50e-04	196	61	4	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	Fetal_29-31_weeks-Endothelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADCY4 MCF2L PCDH17 PROX1	1.50e-04	196	61	4	3981f6c7487598f4f7ce4650ac0ac5bd41481d66
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ITGA9 PCDH17 RYR3	1.50e-04	196	61	4	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	ADCY4 MCF2L ITGA9 PCDH17	1.50e-04	196	61	4	b71b197cb92117dd9efaa13de000841901cc4ca8
ToppCell	Endothelial\|World / Lineage, Cell type, age group and donor	ADCY4 MCF2L PCDH17 PROX1	1.50e-04	196	61	4	96c6d78482a130ce4e29f6629972a06d10d7530e
ToppCell	5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 MCF2L PCDH17 RYR3	1.53e-04	197	61	4	87eda06344498dc66cac292cf89746dc90b5cf67
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_neuro-secretory\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ANO9 FMN2 STAG3 PROX1	1.53e-04	197	61	4	ff4df77117165b6b25315e29b0722cc136eba607
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRUNE2 CACNA1C ITGA9 ABCA10	1.53e-04	197	61	4	0dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ITGA9 PCDH17 RYR3	1.56e-04	198	61	4	07701c73137947ed4a27e225975329235bbb8734
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ITGA9 PCDH17 RYR3	1.56e-04	198	61	4	fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ITGA9 PCDH17 RYR3	1.56e-04	198	61	4	0a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 MCF2L PCDH17 RYR3	1.59e-04	199	61	4	07bda4ac8ffdce1a865ebc99e46c2a27925ff7a8
ToppCell	Bronchial-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADCY4 MCF2L PCDH17 PROX1	1.59e-04	199	61	4	36a230b80096455df26c2e2c8c05fd6b231508c5
ToppCell	Parenchymal-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADCY4 MCF2L PCDH17 PROX1	1.59e-04	199	61	4	a4a9a1c2a34b5a8318a55d1211d6c8661ca9793e
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ADCY4 DIAPH2 MCF2L PCDH17	1.62e-04	200	61	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Control_saline-Endothelial-Endothelial-Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	ADCY4 DIAPH2 MCF2L PCDH17	1.62e-04	200	61	4	3b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCell	Lung_Parenchyma-Control-Endothelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADCY4 MCF2L PCDH17 PROX1	1.62e-04	200	61	4	41ac6adbf61763aa8a81a0ed586c4a5542a42cc5
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ADCY4 DIAPH2 MCF2L PCDH17	1.62e-04	200	61	4	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADCY4 MCF2L PCDH17 PROX1	1.62e-04	200	61	4	5109b417c066ecca0252008206b4f4b7a14c8702
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL7A1 FAT1 SERPINB13 SCNN1G	1.62e-04	200	61	4	8827653738a931e4a4545e0c7d75be12bed40740
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PRUNE2 FAT1 DIAPH2 ITGA9	1.62e-04	200	61	4	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	ADCY4 MCF2L PCDH17 PROX1	1.62e-04	200	61	4	9e5627e11288713aa9b622aae40e849dd6eacd29
ToppCell	Biopsy_Other_PF-Epithelial-Basal\|Biopsy_Other_PF / Sample group, Lineage and Cell type	COL7A1 FAT1 SERPINB13 UGT1A7	1.62e-04	200	61	4	7098ae4b0ea8ba607519eaed8577c577530fc2a1
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Neuronal-GABAergic_neurons\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	CACNA1C H6PD PROX1	2.40e-04	88	61	3	5582fd7bac60c690ecd1f2aff1d446ccb69f79b9
ToppCell	AT2_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	CACNA1C CDAN1 RYR3	7.67e-04	131	61	3	ff4e618bd944f852bbd34438f740187aca82460f
ToppCell	TCGA-Bile_Duct\|World / Sample_Type by Project: Shred V9	OR10Q1 SLCO1B1 PROX1	9.30e-04	140	61	3	ca8a0ccbc2f501b759864fe9bb06dc8b44b6b31f
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-2\|TCGA-Bladder / Sample_Type by Project: Shred V9	PRUNE2 MICU3 RYR3	9.49e-04	141	61	3	1baa054c2ae3b446d1954244b7fbf8af824ef345
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL7A1 SCNN1G ITGA9	9.89e-04	143	61	3	28e936c298a45f88d14f0146caf3d5a22d483cd5
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-7\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	MICU3 ATP8A1 ITGA9	1.03e-03	145	61	3	88090a226ddfa6df59976f025bf0fd84ca0f72ef
ToppCell	Club_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	FAT1 SCNN1G PCDH17	1.07e-03	147	61	3	5a824c89e4d045af465d7333275f8191fb29b041
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP2C2 SCNN1G MCF2L	1.09e-03	148	61	3	f58804d24fe524b42b5090c8658050ea4b14793e
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8A1 RXFP2 FMN2	1.11e-03	149	61	3	48fca6ae33d7722c024b43ce04f4dbce7b6b424b
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRKDC PCDH17 DNAH1	1.16e-03	151	61	3	b698ddc74565d47892c09c3f16d78038da2dd5e7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CATSPER1 OR2AP1 RXFP2	1.16e-03	151	61	3	7b50425d2bbd7b6ff2a6e67d3e2470a4455740e0
Drug	lanthanum	CACNA1C ADCY4 CATSPER1 PKD2L2 ATP2C2 RYR3	1.41e-06	136	59	6	CID000023926
Drug	Bay K 8644	CACNA1C ADCY4 CATSPER1 ATP2C2 RYR3 NOD2	2.50e-06	150	59	6	CID000002303
Drug	verapamil	CACNA1C ADCY4 CATSPER1 KCNJ1 ATP2C2 SCNN1G SLCO1B1 ABCA10 RYR3	4.45e-06	490	59	9	CID000002520
Drug	dihydropyridine	CACNA1C CATSPER1 ATP2C2 SCNN1G RYR3 NOD2	1.06e-05	193	59	6	CID000104822
Drug	Bucladesine sodium salt [16980-89-5]; Up 200; 7.8uM; HL60; HT_HG-U133A	SERPINB13 PKD2L2 MTHFR KCNJ1 H6PD NOD2	1.16e-05	196	59	6	2741_UP
Drug	lamotrigine	CACNA1C CATSPER1 UGT1A7 SCNN1G RYR3	1.27e-05	116	59	5	CID000003878
Drug	caffeine	CACNA1C ADCY4 CATSPER1 PKD2L2 CYP11A1 ATP2C2 EIF3E INO80 RYR3	1.34e-05	562	59	9	CID000002519
Drug	amiloride	CACNA1C CATSPER1 PKD2L2 KCNJ1 SCNN1G RYR3 SLC4A2	1.67e-05	315	59	7	CID000016230
Drug	bepridil	CACNA1C CATSPER1 ATP2C2 SCNN1G RYR3	1.89e-05	126	59	5	CID000002351
Drug	gallopamil	CACNA1C CATSPER1 RYR3 NOD2	2.76e-05	67	59	4	CID000001234
Drug	clotrimazole	KCNJ1 CYP11A1 ATP2C2 H6PD SLCO1B1	3.47e-05	143	59	5	CID000002812
Drug	CAS 298-57-7	CACNA1C CATSPER1 RYR3 NOD2	3.87e-05	73	59	4	CID000002761
Drug	hydride	GUF1 GUCY1B2 HLA-DMA MTHFR KCNJ1 CYP11A1 ATP2C2 SCNN1G H6PD SLC4A2	5.14e-05	835	59	10	CID000000783
Drug	H-Ni	UGT1A7 PRKDC HTT	5.17e-05	28	59	3	CID000445665
Drug	Hydrocortisone	PRUNE2 COL7A1 CYP11A1 SCNN1G H6PD	7.27e-05	167	59	5	ctd:D006854
Drug	gabapentin	CACNA1C CATSPER1 KCNJ1 SCNN1G RYR3	7.69e-05	169	59	5	CID000003446
Drug	felodipine	CACNA1C CATSPER1 CYP11A1 RYR3 NOD2	7.69e-05	169	59	5	CID000003333
Drug	CNS 1145	CACNA1C CATSPER1 RYR3	8.53e-05	33	59	3	CID000190902
Drug	IHC-64	CACNA1C CATSPER1 RYR3	8.53e-05	33	59	3	CID000162753
Drug	nifedipine	CACNA1C COL7A1 CATSPER1 CYP11A1 ATP2C2 RYR3 NOD2	9.58e-05	415	59	7	CID000004485
Drug	NSC7524	CACNA1C ADCY4 CATSPER1 SCNN1G RYR3	1.09e-04	182	59	5	CID000005657
Drug	BAPTA-AM	CACNA1C ADCY4 FAT1 CATSPER1 ATP2C2 RYR3	1.10e-04	293	59	6	CID000002293
Drug	indo-1	CACNA1C FAT1 ATP2C2 RYR3	1.27e-04	99	59	4	CID000105060
Drug	isradipine	CACNA1C CATSPER1 SCNN1G RYR3	1.32e-04	100	59	4	CID000003784
Drug	baclofen	CACNA1C ADCY4 CATSPER1 KCNJ1 RYR3	1.37e-04	191	59	5	CID000002284
Drug	NSC759576	CACNA1C ADCY4 CATSPER1 SLCO1B1 RYR3	1.37e-04	191	59	5	CID000003075
Drug	AC1L1FWE	PPP2R5E EIF2AK4 PRKDC ITGA9	1.43e-04	102	59	4	CID000003422
Drug	Dexamethasone acetate [1177-87-3]; Down 200; 9.2uM; PC3; HT_HG-U133A	COL7A1 ATP2C2 MCF2L CEP43 PCDH17	1.51e-04	195	59	5	5797_DN
Drug	Ethotoin [86-35-1]; Up 200; 19.6uM; MCF7; HT_HG-U133A	PRUNE2 CACNA1C PKD2L2 MTHFR ITGA9	1.51e-04	195	59	5	6052_UP
Drug	Tolnaftate [2398-96-1]; Down 200; 13uM; MCF7; HT_HG-U133A	ATP2C2 H6PD MCF2L EZH1 STAG3	1.51e-04	195	59	5	1501_DN
Drug	3-Acetylcoumarin [3949-36-8]; Up 200; 21.2uM; PC3; HT_HG-U133A	NOD1 PKD2L2 EZH1 PROX1 NOD2	1.54e-04	196	59	5	4664_UP
Drug	Cefixime [79350-37-1]; Up 200; 8.8uM; PC3; HT_HG-U133A	PRUNE2 KCNJ1 ACAN ATP2C2 DIAPH2	1.54e-04	196	59	5	4567_UP
Drug	Sulfapyridine [144-83-2]; Up 200; 16uM; MCF7; HT_HG-U133A	PRUNE2 SERPINB13 ATP8A1 SLCO1B1 PROX1	1.54e-04	196	59	5	6101_UP
Drug	Gliclazide [21187-98-4]; Up 200; 12.4uM; PC3; HT_HG-U133A	SERPINB13 MTHFR KCNJ1 DIAPH2 MCF2L	1.58e-04	197	59	5	5089_UP
Drug	Lactobionic acid [96-82-2]; Up 200; 11.2uM; PC3; HT_HG-U133A	PRUNE2 SERPINB13 MTHFR MCF2L SLCO1B1	1.58e-04	197	59	5	6605_UP
Drug	Prostaglandin E1; Up 200; 10uM; MCF7; HT_HG-U133A	GUF1 RIOK3 HEATR1 PRKDC CEP43	1.58e-04	197	59	5	6576_UP
Drug	Nitrarine dihydrochloride [20069-05-0]; Up 200; 10.6uM; PC3; HT_HG-U133A	PRUNE2 COL7A1 SERPINB13 RYR3 PROX1	1.58e-04	197	59	5	3683_UP
Drug	halothane	CACNA1C ADCY4 CATSPER1 CYP11A1 ATP2C2 RYR3	1.60e-04	314	59	6	CID000003562
Drug	glutamate	CACNA1C ADCY4 CATSPER1 KCNJ1 SCNN1G H6PD RYR3 HTT SLC4A2 NOD2	1.65e-04	962	59	10	CID000000611
Drug	Medrysone [2668-66-8]; Up 200; 11.6uM; MCF7; HT_HG-U133A	ACAN DIAPH2 H6PD SLCO1B1 NOD2	1.66e-04	199	59	5	3603_UP
Drug	Gly-His-Lys acetate salt; Up 200; 1uM; MCF7; HT_HG-U133A	GUF1 NOD1 RIOK3 PRKDC CEP43	1.66e-04	199	59	5	6575_UP
Drug	Cromolyn disodium salt [15826-37-6]; Up 200; 7.8uM; PC3; HT_HG-U133A	PRUNE2 MTHFR ACAN ATP2C2 MCF2L	1.66e-04	199	59	5	5754_UP
Drug	Condelphine [7633-69-4]; Up 200; 8.8uM; PC3; HT_HG-U133A	NOD1 ATP2C2 DIAPH2 EZH1 PCDH17	1.66e-04	199	59	5	6357_UP
Drug	Levodopa [59-92-7]; Up 200; 20.2uM; PC3; HT_HG-U133A	COL7A1 MTHFR ACAN ATP2C2 SLCO1B1	1.66e-04	199	59	5	4571_UP
Drug	Halofantrine hydrochloride [36167-63-2]; Up 200; 7.4uM; HL60; HT_HG-U133A	PRUNE2 COL7A1 MCF2L CEP43 PCDH17	1.69e-04	200	59	5	3130_UP
Drug	5,6-dihydroxy-8-aminoquinoline	HLA-DMA H6PD	1.83e-04	8	59	2	CID000167665
Drug	manganese	CACNA1C ADCY4 CATSPER1 GUCY1B2 HLA-DMA ATP2C2 RIOK3 ITGA9 RYR3	1.87e-04	791	59	9	CID000023930
Drug	AC1L1KS5	CACNA1C ADCY4 CATSPER1 ATP2C2 CEP43 RYR3	2.23e-04	334	59	6	CID000005631
Drug	AC1NBU2S	CACNA1C CATSPER1 GUCY1B2 RYR3	2.42e-04	117	59	4	CID004473765
Disease	X-21339 measurement	UGT1A7 SLCO1B1	7.92e-05	7	58	2	EFO_0800808
Disease	X-11880 measurement	UGT1A7 SLCO1B1	1.35e-04	9	58	2	EFO_0800698
Disease	familial Mediterranean fever (is_implicated_in)	MTHFR NOD2	1.35e-04	9	58	2	DOID:2987 (is_implicated_in)
Disease	X-21796 measurement	UGT1A7 SLCO1B1	2.06e-04	11	58	2	EFO_0800825
Disease	biliverdin measurement	UGT1A7 SLCO1B1	2.47e-04	12	58	2	EFO_0021033
Disease	graft-versus-host disease (is_implicated_in)	MTHFR NOD2	5.07e-04	17	58	2	DOID:0081267 (is_implicated_in)
Disease	Calcium channel blocker use measurement	CACNA1C FAT1 MTHFR RXFP2	8.26e-04	213	58	4	EFO_0009930
Disease	frailty measurement	INO80 HTT	9.36e-04	23	58	2	EFO_0009885
Disease	status epilepticus (biomarker_via_orthology)	CYP11A1 ACAN PROX1	1.02e-03	100	58	3	DOID:1824 (biomarker_via_orthology)
Disease	Dupuytren Contracture	ADCY4 ACAN EIF3E	1.27e-03	108	58	3	EFO_0004229
Disease	lung small cell carcinoma (is_implicated_in)	FAT1 MTHFR	1.39e-03	28	58	2	DOID:5409 (is_implicated_in)
Disease	oral squamous cell carcinoma (is_implicated_in)	FAT1 MTHFR	1.39e-03	28	58	2	DOID:0050866 (is_implicated_in)
Disease	pancreatic cancer (is_implicated_in)	MTHFR UGT1A7 ITGA9	1.41e-03	112	58	3	DOID:1793 (is_implicated_in)
Disease	cerebral infarction (is_implicated_in)	MTHFR ITGA9	1.49e-03	29	58	2	DOID:3526 (is_implicated_in)
Disease	Myopathy	EIF2AK4 SLCO1B1	1.59e-03	30	58	2	C0026848

Protein segments in the cluster

Peptide	Gene	Start	Entry
EFFIRFLESQEFQPS	PPP2R5E	156	Q16537
VRFVSRFTQEIFAFL	SLC4A2	816	P04920
RNLTQSLAFETFIFF	CATSPER1	441	Q8NEC5
FSETQRQFSRYFIEF	EIF2AK4	576	Q9P2K8
QFNFQFDFLTVRENL	ABCA10	476	Q8WWZ4
FFIFFFTLLVLARQN	ADCY4	796	Q8NFM4
RESRFTIRFFTLQFF	ANO9	416	A1A5B4
FFGDLNNFRTLFLEA	DIAPH2	991	O60879
FRDFILSASSFQFNQ	CDAN1	571	Q8IWY9
FVFFDLFNALTCRSQ	ATP2C2	846	O75185
SQFRRAANSFFLFIA	ATP8A1	71	Q9Y2Q0
LFRFSDDAFNTTFIS	RAB10	26	P61026
ANFQLARFQEALSDF	NOXA1	81	Q86UR1
ALRSFNFEQTKAFEF	PCDH17	536	O14917
ADFQNRNDIFVFLLS	INO80	1161	Q9ULG1
VANFFLAFEAQLSVI	GUF1	176	Q8N442
NEFFTFFVRAVDNGS	FAT1	2666	Q14517
RFQVLLESPFEFFQA	PCDHB13	106	Q9Y5F0
ITQLFFEADTFFRFV	MTHFR	226	P42898
YSVDNFTERLQLFEF	MINDY4B	221	A8MYZ0
QAFFTAFFLVLDDRV	NOD1	521	Q9Y239
ITFDEFRSFFQFLNN	MICU3	421	Q86XE3
LRNFSFLEISFTNIF	OR2AP1	61	Q8NGE2
FGLTEFQRKTQFLFE	HS6ST3	351	Q8IZP7
FFATRLEQFTFQEAL	ACAN	581	P16112
ANVSFNVSRELFFIN	ITGA9	671	Q13797
LRFLVQDSLASFSQF	DNAH1	611	Q9P2D7
QFRESEAIIPNIFFF	HTT	1486	P42858
VFLQERTAQLFEGSF	FER1L6-AS2	101	Q96M78
EASAFFIFSSNNRFR	CACNA1C	876	Q13936
SLVAEFLQFFNLDFT	CEP43	76	O95684
FLQFFNLDFTLAVFQ	CEP43	81	O95684
DQLFFFDFSQNTRVP	HLA-DMA	66	P28067
DLFRFAFESITNVIF	CYP11A1	201	P05108
DFIENARLFIFETFC	EIF3E	331	P60228
FFQRTLSDIAFKFNR	MCF2L	171	O15068
TSDFFFFVNDFSILR	COL7A1	191	Q02388
QLTAFFLEALDFRAQ	HEATR1	1866	Q9H583
LDFEFSSGRLFFSQQ	H6PD	511	O95479
NFSERVFCILFQSTF	FMN2	1446	Q9NZ56
EVFFIDFFSIIARRQ	SCNN1G	551	P51170
RFQVLLESPFEFFQA	PCDHB8	106	Q9UN66
FVFRAFTTATEFQVL	OR10Q1	16	Q8NGQ4
VEENRNSLFFFLLFL	TMEM41A	146	Q96HV5
FNYFTETRFILEELN	PRUNE2	66	Q8WUY3
FLEVAQITLREFFNA	PROX1	681	Q92786
TFNIFSIRRFINSQF	GUCY1B2	241	O75343
RRQFEFSVDSFQIVL	TENT5D	166	Q8NEK8
VANRFFFIVFSDAIC	RXFP2	636	Q8WXD0
FQEQRLEHFRLFFVT	IQANK1	521	A8MXQ7
DFFNVKELFSVRSLF	MRPS2	71	Q9Y399
FFVAIQVLNLFFSAL	SLCO1B1	536	Q9Y6L6
LEFLFRDCRNVSQFF	RIOK3	436	O14730
DFQEFLFVFPFSCRQ	NOD2	321	Q9HC29
EFTFFSRADFARSQL	STAG3	656	Q9UJ98
LFFIRHNESNSILFF	SERPINB13	371	Q9UIV8
LSFLRFAVFVNSESV	RYR3	2196	Q15413
FLFNLNNDFVVDATR	EZH1	666	Q92800
FSTFQNSIFAQFRIV	PKD2L2	436	Q9NZM6
LLQDFNRFLNTTFSF	PRKDC	2836	P78527
IFDLFFSNCRSLFND	UGT1A7	116	Q9HAW7
IEFGNVEAQSRFIFF	KCNJ1	51	P48048