Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontriplex DNA binding

DDX11L8 DDX11

4.96e-054582GO:0045142
GeneOntologyMolecularFunction5'-3' DNA helicase activity

DDX11L8 DDX11

4.48e-0411582GO:0043139
GeneOntologyMolecularFunctionstructural constituent of postsynaptic density

DLG3 DLG4

4.48e-0411582GO:0098919
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

TTF2 SMARCAD1 DDX11L8 DDX11

5.08e-04127584GO:0008094
GeneOntologyMolecularFunctionstructural constituent of postsynaptic specialization

DLG3 DLG4

6.34e-0413582GO:0098879
GeneOntologyMolecularFunctionG-quadruplex DNA binding

DDX11L8 DDX11

7.38e-0414582GO:0051880
GeneOntologyMolecularFunctionhelicase activity

TTF2 SMARCAD1 DDX11L8 DDX11

1.15e-03158584GO:0004386
GeneOntologyMolecularFunctionDNA replication origin binding

DDX11L8 DDX11

1.23e-0318582GO:0003688
GeneOntologyMolecularFunctioniron-sulfur cluster binding

AIFM3 DDX11L8 DDX11

1.52e-0378583GO:0051536
GeneOntologyMolecularFunctionmetal cluster binding

AIFM3 DDX11L8 DDX11

1.81e-0383583GO:0051540
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

TTF2 MRPL44 SMARCAD1 VARS1 DDX11L8 POLR3A DDX11

2.56e-03645587GO:0140640
GeneOntologyMolecularFunctionflavin adenine dinucleotide binding

TXNRD1 AIFM3 MTRR

2.58e-0394583GO:0050660
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H

TXNRD1 AIFM3 MTRR

2.66e-0395583GO:0016651
GeneOntologyMolecularFunctionprotein phosphatase binding

PIK3R1 DLG3 DLG4 SIRPG

3.24e-03210584GO:0019903
GeneOntologyBiologicalProcesscellular response to interferon-alpha

IFIT1B GAS6 IFI16

9.37e-0615583GO:0035457
GeneOntologyBiologicalProcessresponse to interferon-alpha

IFIT1B GAS6 IFI16

5.24e-0526583GO:0035455
HumanPhenoAbnormal eyelash morphology

HSPG2 GTPBP2 APCDD1 ASXL3 PYCR2 VARS1 VPS13B POLR3A

2.84e-05284248HP:0000499
HumanPhenoAplasia/Hypoplasia of the eyebrow

GTPBP2 LZTR1 APCDD1 COG6 ASXL3 NSD1 POLR3A

4.18e-05216247HP:0100840
HumanPhenoSparse eyebrow

GTPBP2 LZTR1 APCDD1 COG6 NSD1 POLR3A

5.31e-05151246HP:0045075
HumanPhenoMalar flattening

HSPG2 PIK3R1 ASXL3 DLG3 PYCR2 VPS13B POLR3A

8.20e-05240247HP:0000272
HumanPhenoAbnormal malar bone morphology

HSPG2 PIK3R1 ASXL3 DLG3 PYCR2 VPS13B POLR3A

1.04e-04249247HP:0012369
HumanPhenoAbnormal zygomatic arch morphology

HSPG2 PIK3R1 ASXL3 DLG3 PYCR2 VPS13B POLR3A

1.06e-04250247HP:0005557
HumanPhenoAbnormal zygomatic bone morphology

HSPG2 PIK3R1 ASXL3 DLG3 PYCR2 VPS13B POLR3A

1.06e-04250247HP:0010668
DomainMAGUK_N_PEST

DLG3 DLG4

5.47e-054572PF10608
DomainPDZ_assoc

DLG3 DLG4

5.47e-054572PF10600
DomainDLG1_PEST_dom

DLG3 DLG4

5.47e-054572IPR019590
DomainPDZ_assoc

DLG3 DLG4

5.47e-054572IPR019583
DomainMAGUK_N_PEST

DLG3 DLG4

5.47e-054572SM01277
DomainDLG1

DLG3 DLG4

5.47e-054572IPR016313
Domain-

TXNRD1 AIFM3

1.90e-0475723.30.390.30
DomainApoL

APOL3 APOL4

1.90e-047572IPR008405
DomainApoL

APOL3 APOL4

1.90e-047572PF05461
DomainPyr_nucl-diS_OxRdtase_dimer

TXNRD1 AIFM3

2.53e-048572IPR004099
DomainFAD/NAD-linked_Rdtase_dimer

TXNRD1 AIFM3

2.53e-048572IPR016156
DomainRossmann-like_a/b/a_fold

ASS1 VARS1 NMNAT3

3.05e-0443573IPR014729
Domain-

ASS1 VARS1 NMNAT3

3.05e-04435733.40.50.620
DomainLaminin_G_1

HSPG2 GAS6

4.94e-0411572PF00054
DomainEGF_CA

HSPG2 OIT3 PAMR1 GAS6

5.24e-04122574SM00179
DomainEGF-like_Ca-bd_dom

HSPG2 OIT3 PAMR1 GAS6

5.57e-04124574IPR001881
DomainEGF

HSPG2 FCGBP OIT3 PAMR1 GAS6

7.43e-04235575SM00181
DomainEGF-like_dom

HSPG2 FCGBP OIT3 PAMR1 GAS6

9.63e-04249575IPR000742
DomainGuanylate_kinase_CS

DLG3 DLG4

1.07e-0316572IPR020590
DomainPyr_redox_2

TXNRD1 AIFM3

1.51e-0319572PF07992
DomainSH3_1

PIK3R1 DLG3 DLG4 ARHGEF6

1.58e-03164574PF00018
Domain-

DCAKD TTF2 GTPBP2 LONP2 DLG3 DLG4 SMARCAD1 DDX11

1.82e-037465783.40.50.300
DomainGUANYLATE_KINASE_2

DLG3 DLG4

2.22e-0323572PS50052
DomainGUANYLATE_KINASE_1

DLG3 DLG4

2.22e-0323572PS00856
DomainGuanylate_kin

DLG3 DLG4

2.84e-0326572PF00625
DomainGK/Ca_channel_bsu

DLG3 DLG4

2.84e-0326572IPR008145
DomainGuanylate_kin-like_dom

DLG3 DLG4

2.84e-0326572IPR008144
DomainGuKc

DLG3 DLG4

2.84e-0326572SM00072
Domain-

HSPG2 GAS6 LMAN2

3.06e-03955732.60.120.200
DomainP-loop_NTPase

DCAKD TTF2 GTPBP2 LONP2 DLG3 DLG4 SMARCAD1 DDX11

4.02e-03848578IPR027417
DomainSH3

PIK3R1 DLG3 DLG4 ARHGEF6

4.26e-03216574SM00326
DomainSH3

PIK3R1 DLG3 DLG4 ARHGEF6

4.26e-03216574PS50002
DomainSNF2_N

TTF2 SMARCAD1

4.28e-0332572IPR000330
DomainSNF2_N

TTF2 SMARCAD1

4.28e-0332572PF00176
DomainSH3_domain

PIK3R1 DLG3 DLG4 ARHGEF6

4.54e-03220574IPR001452
DomainDNA/RNA_helicase_DEAH_CS

TTF2 DDX11

5.10e-0335572IPR002464
DomainEGF_3

HSPG2 OIT3 PAMR1 GAS6

5.73e-03235574PS50026
DomainDEAH_ATP_HELICASE

TTF2 DDX11

6.00e-0338572PS00690
DomainLAM_G_DOMAIN

HSPG2 GAS6

6.00e-0338572PS50025
DomainKH_1

MEX3A MEX3C

6.00e-0338572PF00013
Domain-

MEX3A MEX3C

6.31e-03395723.30.1370.10
DomainKH

MEX3A MEX3C

6.63e-0340572SM00322
DomainKH_dom

MEX3A MEX3C

6.63e-0340572IPR004087
DomainLaminin_G_2

HSPG2 GAS6

6.63e-0340572PF02210
DomainEGF

HSPG2 PAMR1 GAS6

6.73e-03126573PF00008
DomainKH_TYPE_1

MEX3A MEX3C

7.29e-0342572PS50084
DomainEGF_1

HSPG2 OIT3 PAMR1 GAS6

7.61e-03255574PS00022
DomainKH_dom_type_1

MEX3A MEX3C

7.97e-0344572IPR004088
DomainLamG

HSPG2 GAS6

7.97e-0344572SM00282
Pubmed

Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development.

DLG3 DLG4

2.73e-06258219104036
Pubmed

Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies.

DLG3 DLG4

2.73e-06258217344405
Pubmed

Clustered gene expression changes flank targeted gene loci in knockout mice.

DLG3 DLG4

2.73e-06258218074027
Pubmed

Synaptic state-dependent functional interplay between postsynaptic density-95 and synapse-associated protein 102.

DLG3 DLG4

2.73e-06258223946397
Pubmed

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.

IFIT1B APOL3 APOL4

5.73e-062158335859175
Pubmed

A brain atlas of synapse protein lifetime across the mouse lifespan.

DLG3 DLG4

8.19e-06358236202095
Pubmed

SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family.

DLG3 DLG4

8.19e-0635829581761
Pubmed

CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95.

DLG4 NOS1AP

8.19e-0635829459447
Pubmed

MAGUKs are essential, but redundant, in long-term potentiation.

DLG3 DLG4

8.19e-06358234244435
Pubmed

Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.

DLG3 DLG4

8.19e-06358223486974
Pubmed

Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model.

DLG3 DLG4

8.19e-06358236369219
Pubmed

Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.

DDX11L8 DDX11

8.19e-06358217611414
Pubmed

Architecture of the Mouse Brain Synaptome.

DLG3 DLG4

8.19e-06358230078578
Pubmed

The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis.

DLG3 DLG4

8.19e-06358225780553
Pubmed

Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.

DLG3 DLG4

8.19e-06358217046693
Pubmed

Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference.

DLG3 DLG4

8.19e-06358228077487
Pubmed

Mammalian ChlR1 has a role in heterochromatin organization.

DDX11L8 DDX11

8.19e-06358221854770
Pubmed

Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites.

DLG3 DLG4

8.19e-06358210026200
Pubmed

Standardized experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds.

DLG3 DLG4

8.19e-06358227886459
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

TTF2 ASS1 SRM ACOT7 SMARCAD1 ATIC DHRS2 PYCR2 IFI16 VARS1 POLR3A

1.26e-051353581129467282
Pubmed

CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness.

MEX3A MEX3C

1.64e-05458223408853
Pubmed

Mouse Apolipoprotein L9 is a phosphatidylethanolamine-binding protein.

APOL3 APOL4

1.64e-05458227697524
Pubmed

Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.

APOL3 APOL4

1.64e-05458211290834
Pubmed

Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102.

DLG3 DLG4

1.64e-05458212576483
Pubmed

The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment.

PIK3R1 DLG4

1.64e-05458220467438
Pubmed

The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.

APOL3 APOL4

1.64e-05458211944986
Pubmed

Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting.

DLG3 DLG4

1.64e-05458210595517
Pubmed

Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex.

DLG3 DLG4

1.64e-05458221031555
Pubmed

Synaptic scaffold evolution generated components of vertebrate cognitive complexity.

DLG3 DLG4

1.64e-05458223201973
Pubmed

Profile of cortical N-methyl-D-aspartate receptor subunit expression associates with inherent motor impulsivity in rats.

DLG3 DLG4

1.64e-05458231295463
Pubmed

Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.

TXNRD1 PIK3R1 ASXL3

1.73e-053058338310234
Pubmed

Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95.

DLG3 DLG4

2.72e-05558211134026
Pubmed

Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins.

DLG3 DLG4

2.72e-05558212713445
Pubmed

Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis.

MTRR ATIC

2.72e-05558216947783
Pubmed

The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.

DLG3 DLG4

2.72e-05558210725395
Pubmed

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.

DLG3 DLG4

2.72e-05558226352593
Pubmed

Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis.

MTRR ATIC

2.72e-05558217009228
Pubmed

SAP90 binds and clusters kainate receptors causing incomplete desensitization.

DLG3 DLG4

2.72e-0555829808460
Pubmed

Insulin receptor substrate of 53 kDa links postsynaptic shank to PSD-95.

DLG3 DLG4

2.72e-05558215255944
Pubmed

Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls.

DLG4 NOS1AP

4.08e-05658220921115
Pubmed

Differential gene expression during terminal erythroid differentiation.

APOL3 APOL4

4.08e-05658217764892
Pubmed

NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex.

DLG3 DLG4

4.08e-05658212738960
Pubmed

The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.

APOL3 APOL4

4.08e-05658211374903
Pubmed

Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.

DLG3 DLG4

4.08e-05658211572861
Pubmed

Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins.

DLG3 DLG4

4.08e-05658211274188
Pubmed

PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.

DLG3 DLG4

4.08e-05658222246437
Pubmed

Disruption of the NMDA receptor-PSD-95 interaction in hippocampal neurons with no obvious physiological short-term effect.

DLG3 DLG4

4.08e-05658214529713
Pubmed

Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.

DLG3 DLG4

4.08e-05658219118189
Pubmed

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.

MEX3A MEX3C

4.08e-05658217267406
Pubmed

Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity.

DLG3 DLG4

4.08e-05658228973854
Pubmed

Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.

DLG3 DLG4

5.71e-05758219243221
Pubmed

Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses.

DLG3 DLG4

5.71e-05758211997254
Pubmed

SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.

DLG3 DLG4

5.71e-0575829115257
Pubmed

A novel family of adhesion-like molecules that interacts with the NMDA receptor.

DLG3 DLG4

5.71e-05758216495444
Pubmed

Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.

DLG3 DLG4

7.60e-05858223397623
Pubmed

The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family.

DLG3 DLG4

7.60e-05858210958799
Pubmed

The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis.

DDX11L8 DDX11

7.60e-05858222678773
Pubmed

The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins.

DLG3 DLG4

7.60e-05858214988405
Pubmed

Btbd11 supports cell-type-specific synaptic function.

DLG3 DLG4

7.60e-05858237261953
Pubmed

Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation.

LZTR1 AIFM3

7.60e-05858225658046
Pubmed

LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.

TXNRD1 TTF2 ASS1 ATIC

9.52e-0514258430809309
Pubmed

Identification of novel germline polymorphisms governing capecitabine sensitivity.

MTRR SMARCAD1

9.77e-05958222864933
Pubmed

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems.

DLG3 DLG4

9.77e-05958217526495
Pubmed

Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration.

PIK3R1 SIRPG

9.77e-05958211895767
Pubmed

Binding of neuroligins to PSD-95.

DLG3 DLG4

9.77e-0595829278515
Pubmed

The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.

DLG3 DLG4

9.77e-05958217938206
Pubmed

Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.

PIK3R1 DLG3 DLG4

1.15e-045658322745667
Pubmed

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

TCEA3 SMARCAD1 NOS1AP

1.21e-045758324952745
Pubmed

Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis.

MTRR ATIC

1.22e-041058219858780
Pubmed

Defining the membrane proteome of NK cells.

DCAKD EHBP1L1 LONP2 PIK3R1 CNTRL APOL3 ATIC IFI16 POLR3A

1.28e-04116858919946888
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

DCAKD HSPG2 ASXL3 MRPL44 IFIT1B ASS1 LMAN2 PYCR2 VARS1 NMNAT3

1.30e-041451581030550785
Pubmed

DGKι regulates presynaptic release during mGluR-dependent LTD.

DLG3 DLG4

1.49e-041158221119615
Pubmed

NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation.

DLG3 DLG4

1.78e-041258216980967
Pubmed

Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules.

MEX3A MEX3C

1.78e-041258218779327
Pubmed

Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.

DLG3 DLG4

1.78e-041258211937501
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

EHBP1L1 LZTR1 COG6 APOL3 APOL4 DLG3 DLG4 DHRS2 PYCR2

2.02e-04124258930973865
Pubmed

Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.

PIK3R1 DHRS2 IFI16

2.04e-046858325754235
Pubmed

A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve.

APCDD1 ASXL3

2.11e-041358236325906
Pubmed

Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.

MTRR ATIC

2.11e-041358219936946
Pubmed

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.

APOL3 APOL4

2.46e-041458234380029
Pubmed

Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility.

GTPBP2 DLG4

2.83e-041558232853550
Pubmed

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

TTF2 HSPG2 ATIC IFI16 VARS1

2.93e-0434958525665578
Pubmed

Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.

DLG3 DLG4

3.23e-041658221920314
Pubmed

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.

DCAKD MRPL44 PYCR2 NMNAT3

4.02e-0420758431056398
Pubmed

Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.

PIK3R1 DLG3 DLG4

4.08e-048658310862698
Pubmed

Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.

DLG3 DLG4

4.11e-041858219455133
Pubmed

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.

DLG4 NOS1AP

4.11e-041858210827173
Pubmed

Genes, plasticity and mental retardation.

DLG3 ARHGEF6

4.59e-041958218329113
Pubmed

Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.

DLG3 DLG4

4.59e-041958215024025
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

GTPBP2 LZTR1 PIK3R1 GAS6 ASS1 DLG4 SMARCAD1 NOS1AP

5.06e-04111658831753913
Pubmed

IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5.

TXNRD1 SRM LMAN2 AHCYL2

5.15e-0422158431950832
Pubmed

The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling.

PIK3R1 DLG4

5.62e-042158231577955
Pubmed

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.

IFIT1B IFI16

5.62e-042158219158679
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DLG3 SMARCAD1 AHCYL2 VPS13B NOS1AP

5.90e-0440758512693553
Pubmed

EG-1 interacts with c-Src and activates its signaling pathway.

PIK3R1 DLG4

6.18e-042258216964398
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

SNX25 NSD1 VARS1 VPS13B

6.37e-0423458436243803
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

TXNRD1 CDAN1 EHBP1L1 ASS1 ACOT7 MTRR SMARCAD1 ATIC VARS1

6.41e-04145558922863883
Pubmed

Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.

DLG3 DLG4

6.76e-042358216637659
Pubmed

High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.

DLG3 DLG4

7.37e-042458222632720
Pubmed

Common variants at ten loci influence QT interval duration in the QTGEN Study.

ACOT7 NOS1AP

8.00e-042558219305408
Cytoband3q23

PRR23C NMNAT3

1.43e-03445823q23
Cytoband1q22

MEX3A IFI16

2.39e-03575821q22
CytobandEnsembl 112 genes in cytogenetic band chr3q23

PRR23C NMNAT3

2.92e-0363582chr3q23
CytobandEnsembl 112 genes in cytogenetic band chr5q35

STC2 NSD1 LMAN2

3.32e-03235583chr5q35
GeneFamilyApolipoproteins

APOL3 APOL4

6.64e-0421332405
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

DLG3 DLG4

1.02e-0326332904
ToppCelltumor_Lymph_Node_/_Brain|World / Location, Cell class and cell subclass

TXNRD1 TCEA3 APCDD1 ASS1 AHCYL2

5.66e-06196585b39f938cbef54f08c53035738b97c76e7295733a
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 GAS6 APOL3 HIF3A IFI16

6.10e-0619958514e09eaa2335d4503de50250eb4258dd5b85b304
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 GAS6 APOL3 HIF3A IFI16

6.25e-062005853007583eaad3a5ae2df010513d3e4df59155123d
ToppCellkidney_cells-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 GAS6 APOL3 HIF3A IFI16

6.25e-062005859f1626a7e1bd00977a5c316cafbdf654b52bad94
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

APCDD1 AIFM3 SMARCAD1 AHCYL2

2.58e-051315841823cab28fab40486247ca92104267b1e370bdc1
ToppCellClub_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

CDAN1 CYP2A13 MEX3A ASS1

4.73e-0515358477030b0e033f3635b1bbe7552a28c074ea7bb106
ToppCellURO-Other-RBC|URO / Disease, Lineage and Cell Type

TXNRD1 DCAKD TCEA3 GAS6

5.63e-05160584558f3b0719e2461a69e1b93b08e21675e8d07a5a
ToppCellURO-Other|URO / Disease, Lineage and Cell Type

TXNRD1 DCAKD TCEA3 GAS6

5.63e-05160584b0923e6bacfaba8ca40aa5706bf270eea0938b0a
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

HSPG2 ASS1 APOL3 HIF3A

7.28e-051715841597459c971d6befa991d59dc66b41b6a522f797
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

HSPG2 ASS1 APOL3 APOL4

7.62e-051735843a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCellTCGA-Brain-Primary_Tumor|TCGA-Brain / Sample_Type by Project: Shred V9

DCAKD AHCYL2 HIF3A ARHGEF6

7.62e-05173584f6ba22661e67c17d49d1058d4170ba8f36bf47f0
ToppCellrenal_papilla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 APCDD1 HIF3A DHRS2

8.88e-0518058449829e833fe6d2431cfd2e8f378c2aaa3b2b46a4
ToppCellcritical-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

HSPG2 SIGLEC8 ACOT7 ARHGEF6

9.07e-05181584f0d81ae74d3f32979624a94b2ef93774831a7970
ToppCell3'_v3-lymph-node_spleen-Mast|lymph-node_spleen / Manually curated celltypes from each tissue

HSPG2 SIGLEC8 ACOT7 NOS1AP

9.67e-0518458483675c7a083c52fb74dc8b9d35df0ef69715f707
ToppCell3'_v3-lymph-node_spleen-Mast-Mast_cells|lymph-node_spleen / Manually curated celltypes from each tissue

HSPG2 SIGLEC8 ACOT7 NOS1AP

9.67e-05184584ed266bd2d12f86e8786473e64fbcd58319cd4c2a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PAMR1 APCDD1 AIFM3 HIF3A

1.03e-04187584dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PAMR1 APCDD1 AIFM3 HIF3A

1.03e-041875844d2115a05ec36dd179ca1d4a525f2d4501aea557
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PAMR1 APCDD1 AIFM3 HIF3A

1.03e-04187584ae90c263f80c36a410150d499e268d198944a3d9
ToppCelldroplet-Marrow-nan-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASS1 SRM ACOT7 ATIC

1.05e-041885849fc3f17045606f1fe29d296326da9482db58433b
ToppCelldroplet-Marrow-nan-21m-Myeloid-Cd4_positive_Macrophages|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASS1 SRM ACOT7 ATIC

1.05e-04188584f94dc08948a823f47882aa0714b9a60de4ff85d5
ToppCelldroplet-Marrow-BM-30m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASS1 SRM ACOT7 ATIC

1.05e-04188584bf77e59b9001c7f7ca17f81073f935f281a25a1f
ToppCelldroplet-Marrow-nan-18m-Myeloid-Cd4_positive_Macrophages|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASS1 SRM ACOT7 ATIC

1.05e-041885841ff13434dfe60c8184d5f33041e325eca41392bc
ToppCelldroplet-Marrow-BM-30m-Myeloid-Cd4_positive_Macrophages|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASS1 SRM ACOT7 ATIC

1.05e-04188584b2472a294b25fc2f0da7f18519fdcb9ca166c6f0
ToppCelldroplet-Marrow-nan-21m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASS1 SRM ACOT7 ATIC

1.05e-041885847c67330c36696a7772364af67c6df4e6406fa742
ToppCelldroplet-Marrow-BM-1m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASS1 SRM ACOT7 ATIC

1.07e-04189584b81540e097e95158851e07bfd78640ed6e64c2cf
ToppCelldroplet-Marrow-BM-1m-Myeloid-Cd4_positive_Macrophages|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASS1 SRM ACOT7 ATIC

1.07e-041895840fda1a3f1e87fadf5309c8267beaa4501983b1dd
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 APCDD1 APOL3 HIF3A

1.07e-041895846463890d8dbee4bc198f91628a5f784970de786a
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX25 GAS6 ACOT7 AHCYL2

1.09e-041905848ff8c586237cf15f930416710bcff45205fe6f70
ToppCellHSPCs-Gran/Mono_prog.|World / Lineage and Cell class

ASS1 SRM ACOT7 ATIC

1.09e-0419058494547c1cc2c3f2ac28a6d07317e50e1e3fd20267
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCEA3 CYP2A13 FCGBP ASS1

1.12e-04191584e96184aee03175fd9f1da11fa2b89d95ba58b817
ToppCellPND14-Epithelial-Epithelial_Alveolar|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX25 GAS6 ACOT7 AHCYL2

1.12e-041915845f8b3b2d38b37027901db9a1cccdbd1ff70f29de
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX25 GAS6 ACOT7 AHCYL2

1.12e-041915842f71f1fb6b5872d84860840b22e789a87ab14eec
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX25 GAS6 ACOT7 AHCYL2

1.12e-041915844ab3056f9af2a6caed39f32288562f480811cd7b
ToppCellPND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX25 GAS6 ACOT7 AHCYL2

1.14e-041925847ccdb977320d09f21e70e7718ead73eeb56d0c48
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_Erythro-Mega|bone_marrow / Manually curated celltypes from each tissue

HSPG2 MEX3A APOL4 NMNAT3

1.14e-04192584cbc304c704e8524eee24a1619d0fbb2cf96c4976
ToppCellPND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX25 GAS6 ACOT7 AHCYL2

1.14e-04192584f206c015f091234e2c86dfa66926e97b2ea99690
ToppCellPND28-Epithelial-Epithelial_Alveolar|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX25 GAS6 ACOT7 AHCYL2

1.14e-0419258469963e8dc6d6368243e61da133484eb23225625a
ToppCellPND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX25 GAS6 ACOT7 AHCYL2

1.14e-04192584bfc68af68fdb99ddfe4add49671e4b4c26e6f962
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCEA3 CYP2A13 FCGBP ASS1

1.16e-0419358421c397912f2dd1f4115cddbdc01a6a9beb1332cc
ToppCellsevere-Plasmablast|World / disease stage, cell group and cell class

GAS6 SRM LMAN2 VARS1

1.19e-0419458449e8f90db571a89b8a26aef31fcacd66429fed11
ToppCellcellseq-Epithelial-Epithelial_Glandular|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TCEA3 CYP2A13 FCGBP ASS1

1.19e-04194584d0fb1ff5cf0738881e114a58f0b27489f781d72b
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteoblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TCEA3 PAMR1 APCDD1 ASS1

1.19e-04194584292ce9021678534c9eedb367b9772a9d976208a8
ToppCellCOVID-19-kidney-PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

HSPG2 STC2 HIF3A IFI16

1.21e-04195584a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 APOL3 HIF3A IFI16

1.21e-041955846bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCEA3 CYP2A13 FCGBP ASS1

1.21e-04195584460e12044905370797fd9774e99c3aedaebfe343
ToppCellBronchial-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TCEA3 CYP2A13 FCGBP ASS1

1.21e-04195584fc2a1d84b3d013e5cb9e7b9cdd740e4010897d20
ToppCellNS-critical-LOC-Epithelial-Secretory|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TCEA3 HSPG2 FCGBP ASS1

1.21e-04195584b0d782eeee30c797b4da9b3be29b864983fd9e71
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

MRPL44 APOL3 IFI16 NMNAT3

1.21e-04195584b64d9e1a8834401b4dc501566546647754ae21fc
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCEA3 CYP2A13 FCGBP ASS1

1.21e-04195584ff9f6b38f41dc5660b746fe40ceaddfb2958acd3
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCEA3 CYP2A13 FCGBP ASS1

1.21e-041955846095bb237d7bc75cbaeaeb492f6948f3c3fa4848
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCEA3 CYP2A13 FCGBP ASS1

1.23e-04196584c18874f37b90e6afacc562b2082b67ea8a7cb4a4
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCEA3 CYP2A13 FCGBP ASS1

1.23e-041965841ff4b41817556a6e573f0737819a5cc24a7ef821
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 APOL3 HIF3A IFI16

1.23e-04196584b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCellBronchial_Biopsy-Epithelial-Club|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

TCEA3 CYP2A13 FCGBP ASS1

1.23e-04196584057d150bdf0cad959fd03ec2d1560a96ba03fae9
ToppCell10x5'v1-week_17-19-Mesenchymal_osteo-stroma-osteoblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TCEA3 PAMR1 ASS1 APOL4

1.23e-04196584d5ed41fa111750e6b363c04cccc40a47dd774852
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 APOL3 HIF3A IFI16

1.23e-04196584d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCell10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteoblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TCEA3 PAMR1 APCDD1 ASS1

1.23e-04196584760885dc608c82768fe0decd63ed9fda8315f453
ToppCellILEUM-inflamed-(7)_Endothelial_cell-(7)_CD36+_endothelial_cells|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

GAS6 ASS1 HIF3A IFI16

1.26e-0419758466339b5aae3952f5c484c9dcb0cfb4fbd828d4cb
ToppCellCOVID-19-Epithelial-Club,_Basal_cells|Epithelial / Condition, Lineage and Cell class

CYP2A13 FCGBP ASS1 NOS1AP

1.26e-0419758478ed2810e5a765327e7a6da0ca5d4854bf7a0b6f
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HSPG2 APCDD1 ASS1 HIF3A

1.26e-041975843bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCellmild-dn_T|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SNX25 CNTRL ARHGEF6 SIRPG

1.26e-0419758407a1f59c83b748825e0708cd1cc7b63a2cb856cc
ToppCellBronchial_Biopsy-Epithelial-Club|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

TCEA3 CYP2A13 FCGBP ASS1

1.26e-041975843f5dfa892a1f631b96eeb6f4cfc284aee51d1ce6
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HSPG2 APCDD1 ASS1 HIF3A

1.26e-0419758417344464fdcc5ba0c03959696b97c195f11e644c
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STC2 GAS6 APOL3 HIF3A

1.26e-04197584ca6bce1a92c6326f41a6300c31da02386bafa152
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HSPG2 APCDD1 ASS1 HIF3A

1.26e-041975845b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCellBronchial_Brush-Epithelial-Club|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

TCEA3 CYP2A13 FCGBP ASS1

1.28e-0419858461292a2b5aacb6080a679a31b70a211bdec59a3b
ToppCellSepsis-URO-Others|URO / Disease, condition lineage and cell class

TXNRD1 DCAKD TCEA3 GAS6

1.28e-041985846caab5266da666cfbe92ac1ace26ad2004e5aa09
ToppCellSepsis-URO-Others-RBC|URO / Disease, condition lineage and cell class

TXNRD1 DCAKD TCEA3 GAS6

1.28e-04198584d35e9d0952b3f7cd5d0d1a69bad2ae81af8eed50
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCEA3 CYP2A13 FCGBP ASS1

1.28e-04198584778fee7020c82d11ff3984a8e482a23e5d58165f
ToppCellCD8+_Memory_T_cell-FLU-2|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

TTF2 ACOT7 ATIC SIRPG

1.28e-041985849813578a58cdedf68b57a0a5e3cf190c9c25a4cd
ToppCelldistal-1-Endothelial-Vein|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HSPG2 GAS6 ASS1 HIF3A

1.28e-04198584eee6cb4fe0e1caf460869d5a0a57c9d259573f10
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

HSPG2 APOL3 HIF3A IFI16

1.28e-041985848689090bce9ab6e8f122426a404037e572c6713b
ToppCellCOVID-19_Severe-cDC|COVID-19_Severe / Disease condition and Cell class

TCEA3 GAS6 SRM ATIC

1.28e-04198584e0b16627a347e245bedd71b1e0ccdb46c1c1bd6d
ToppCellCOVID-19_Severe-cDC-|COVID-19_Severe / Disease condition and Cell class

TCEA3 GAS6 SRM ATIC

1.28e-041985843914140238598914674c08c5ad83354b9485825f
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-B-Plasmablast|COVID-19_Severe / Disease, condition lineage and cell class

GAS6 SRM LMAN2 VARS1

1.31e-04199584e6422b65e22e5aa8dfaebdae5be76dd78b978604
ToppCellBronchial_Brush-Epithelial-Club|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

TCEA3 CYP2A13 FCGBP ASS1

1.31e-0419958453b87edccc89a3e8a6c5166472f9ef24fcba416c
ToppCellBiopsy_Control_(H.)-Epithelial-MUC5B+|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

TCEA3 CYP2A13 FCGBP ASS1

1.31e-041995844ab45996e6bca406c77895a5998982b8ab1cf210
ToppCellcontrol-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PIK3R1 ASS1 NSD1 IFI16

1.31e-041995843d01f90ffd271ca00129192787e4921bdca7e01e
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

TCEA3 PAMR1 PIK3R1 NMNAT3

1.33e-04200584c5e051f1aac8dda376c342a9932785a23450e073
ToppCellMacroglial-Astrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

PAMR1 AIFM3 AHCYL2 HIF3A

1.33e-04200584941536b7c32f1e63c70535233b2ccce0cd7bf96e
ToppCellMacroglial-Astrocytes-SLC14A1---|Macroglial / cells hierarchy compared to all cells using T-Statistic

PAMR1 AIFM3 AHCYL2 HIF3A

1.33e-04200584d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCellMacroglial-Astrocytes-SLC14A1----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

PAMR1 AIFM3 AHCYL2 HIF3A

1.33e-04200584f861509b54185d89931db64da1b9d81986cc7938
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

TCEA3 PAMR1 PIK3R1 NMNAT3

1.33e-042005849d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TCEA3 PAMR1 PIK3R1 NMNAT3

1.33e-0420058487827041663013f5e7273168dc8709d69840e7ce
ToppCell(5)_Fibroblasts-(5)_Fibroblast-H|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

ASS1 SRM ATIC VARS1

1.33e-042005840ebc54d19873a2b7b6d12b81559cb12abd73b90c
ToppCellMacroglial-Astrocytes-SLC14A1|Macroglial / cells hierarchy compared to all cells using T-Statistic

PAMR1 AIFM3 AHCYL2 HIF3A

1.33e-0420058416f468217427921fa18c6d078ffa990eb019b257
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TCEA3 PAMR1 PIK3R1 NMNAT3

1.33e-042005848988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCellMacroglial-Astrocytes-SLC14A1--|Macroglial / cells hierarchy compared to all cells using T-Statistic

PAMR1 AIFM3 AHCYL2 HIF3A

1.33e-042005840442894c39eec69850c090957a5dc7bcecd21e04
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Intermediate|10w / Sample Type, Dataset, Time_group, and Cell type.

HSPG2 NSD1 MEX3C POLR3A

1.33e-04200584e5a8647c47a49c8c90c78d681193946de103d8ff
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Goblet|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TCEA3 CYP2A13 FCGBP ASS1

1.33e-04200584133853d0f55c63ebe94dd54151f9f1f90650a0d8
ToppCellMacroglial-Astrocytes-SLC14A1-|Macroglial / cells hierarchy compared to all cells using T-Statistic

PAMR1 AIFM3 AHCYL2 HIF3A

1.33e-0420058401819446deeab9054f5cfe889d53bb49d137dbc0
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_secretory|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TCEA3 CYP2A13 FCGBP ASS1

1.33e-042005848f811ddd84c037a250d124496b0fbb2e4717011c
ToppCelldroplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCEA3 STC2 AIFM3

3.57e-04106583c890c838785dfeda30f3b563194da9cfb49b157a
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-Unfolded_protein_responsible_cell|GW23 / Sample Type, Dataset, Time_group, and Cell type.

PIK3R1 DLG4 C2CD2

3.67e-041075837fee0193ee02e9cc62f506660ea7ec23fb4d0c84
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_26.46.91|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PAMR1 PIK3R1 APOL4

6.33e-041295836abdba987c8528f7cb90b32dc01796e02c7352c9
ToppCellNS-moderate-d_07-13-Epithelial-IRC-IFNG_responsive_cell|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GPR161 OIT3 ASS1

7.38e-041365837f1ca43e0d164b511120316d4218d80ba21a9b5c
ToppCellCOVID-19_Mild-PLT_3|World / Disease Group and Platelet Clusters

CDAN1 IFIT1B PPBP

9.24e-041475839d3271aa735ddb6f32ab864d7afcfb0f8754383b
ToppCell356C-Myeloid-Mast_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

SIGLEC8 ACOT7 ARHGEF6

9.43e-041485831668d8a9e680da335362744f36b05446c499347e
ToppCellfacs-Liver-Non-hepatocytes-24m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAMR1 ASS1 PPBP

9.43e-041485835c853637f6058f78608ba0e76cda72a548d40710
ToppCellfacs-Liver-Non-hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAMR1 ASS1 PPBP

9.43e-04148583763c598826445bf627989220cd7acd71c4f1ea36
DiseaseWarsaw breakage syndrome (implicated_via_orthology)

DDX11L8 DDX11

1.06e-053562DOID:0060535 (implicated_via_orthology)
Diseasebenign neoplasm (implicated_via_orthology)

DLG3 DLG4

9.83e-058562DOID:0060072 (implicated_via_orthology)
DiseaseIntellectual Disability

GTPBP2 ASS1 NSD1 DLG4 ATIC PYCR2

2.00e-04447566C3714756
DiseaseMental Retardation, X-Linked Nonsyndromic

DLG3 ARHGEF6

2.72e-0413562C3501611
DiseaseMental Retardation, X-Linked

DLG3 ARHGEF6

1.39e-0329562C1136249
DiseaseMental Retardation, X-Linked 1

DLG3 ARHGEF6

1.69e-0332562C2931498

Protein segments in the cluster

PeptideGeneStartEntry
EVAGIVAARHCKTNI

ACOT7

256

O00154
GETEVTEKCNHIREV

CNTRL

1631

Q7Z7A1
FEITGNTVERIVVHC

ARHGEF6

516

Q15052
KVVRADVCVVGIGAV

AIFM3

416

Q96NN9
NEIEKVHRGCVIANV

APOL4

131

Q9BPW4
TVHVGNVRQTAVVEK

GTPBP2

526

Q9BX10
VEFVAERIGSNCVKH

CDAN1

866

Q8IWY9
VARTVGEHTQVKCEP

ASXL3

1831

Q9C0F0
HCIAKSQERVEGKVQ

ASS1

336

P00966
EVEIVGVQEHARCVH

C18orf25

331

Q96B23
VQEQVHKVSSRCEEE

NSD1

1301

Q96L73
SVQTVVVGHAVEFEC

HSPG2

3496

P98160
ICRAVAVKVAEGQHK

LONP2

571

Q86WA8
EKEECVQGHVAIVTA

LZTR1

451

Q8N653
VCAVVGAVVFQKRQE

LMAN2

336

Q12907
KAIAEEICEQAVVHG

MTRR

16

Q9UBK8
TCGTVVDVVNDKIVA

OIT3

311

Q8WWZ8
VCQVDAEQRSKVRHV

EHBP1L1

421

Q8N3D4
VVVDGEVKHCVINKT

PIK3R1

661

P27986
FAQVVKECRAVVIAG

DDX11

606

Q96FC9
NIQEVVGHITEGVCR

COG6

341

Q9Y2V7
RSAEEKVVVCHVVGQ

C2CD2

121

Q9Y426
RRVVVLCGHDAVKEA

CYP2A13

76

Q16696
CAVIDVDVMARHVVQ

DCAKD

26

Q8WVC6
RVVAEVQICHGKTEA

FCGBP

5276

Q9Y6R7
EIKVCDGQEHVVTVS

GAS6

566

Q14393
VHFAQVVKECRAVVI

DDX11L8

606

A8MPP1
VEAERVVEFSCGHVI

DDX11L8

641

A8MPP1
AKRCIHQNVRVVESV

IFIT1B

426

Q5T764
GIEEVHRGCTISNVV

APOL3

176

O95236
QVICHTEAVAEKLGQ

APCDD1

151

Q8J025
IQSVRAVAERGKHCI

DLG3

706

Q92796
VREVAEQGKHCILDV

DLG4

616

P78352
VVVHGRLTTINCEEG

IFI16

716

Q16666
KVHCGTVVIVEEDAQ

GPR161

221

Q8N6U8
RIVRTVGQAFEVCHK

NOS1AP

156

O75052
VCHVGKAEDREQLVA

DHRS2

91

Q13268
EVIGKGTHCNQVEVI

PPBP

81

P02775
GALVNERTVVVAAHC

PAMR1

491

Q6UXH9
CDHAGIATQVVVEKK

VARS1

381

P26640
TGEEVVCHVARNLAV

MRPL44

161

Q9H9J2
VITCTGNKNVVTREH

AHCYL2

451

Q96HN2
DRCHRVGQTKEVLVI

SMARCAD1

961

Q9H4L7
SHVDVVKVVCNDVVR

SNX25

51

Q9H3E2
CVHFLISQVEETGVV

HIF3A

336

Q9Y2N7
SEHVAEIVGRQGCKI

MEX3C

241

Q5U5Q3
AVHGEAVVCVTPREN

POLR3A

1166

O14802
VQELVTVQEGLCVHV

SIGLEC8

31

Q9NYZ4
EIGADVQARHIVVSC

PYCR2

81

Q96C36
QRDDVVLTCQVKHDG

SIRPG

321

Q9P1W8
ICNTKDNERVVGFHV

TXNRD1

576

Q16881
SEHVAEIVGRQGCKI

MEX3A

141

A1L020
CGEEVKEAITHSVQV

STC2

181

O76061
AVNGVRKHCSDKEVV

TCEA3

51

O75764
VVKHPSVESVVQCEI

SRM

111

P19623
AKNHARVTVVCEPED

ATIC

136

P31939
VDVVHQCGTVFITVA

VPS13B

3351

Q7Z7G8
HGEDVVVEQEVCASV

PRR23C

131

Q6ZRP0
GQQKDVVIHRFVCEG

TTF2

1106

Q9UNY4
VVIHRFVCEGTVEEK

TTF2

1111

Q9UNY4
AHIQEIVEKFGLVCV

NMNAT3

151

Q96T66