Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionNotch binding

JAG2 ATRNL1 JAG1

5.61e-0627263GO:0005112
GeneOntologyMolecularFunctioncalcium ion binding

JAG2 VIL1 FAT4 TBC1D8B NOTCH2 JAG1

3.30e-04749266GO:0005509
GeneOntologyBiologicalProcessciliary body morphogenesis

NOTCH2 JAG1

2.28e-056262GO:0061073
GeneOntologyBiologicalProcessepithelial cell differentiation involved in kidney development

FAT4 NOTCH2 JAG1

2.78e-0547263GO:0035850
GeneOntologyBiologicalProcesscell fate determination

JAG2 NOTCH2 JAG1

3.35e-0550263GO:0001709
GeneOntologyBiologicalProcesscell differentiation involved in kidney development

FAT4 NOTCH2 JAG1

4.97e-0557263GO:0061005
GeneOntologyBiologicalProcessglomerular epithelial cell development

NOTCH2 JAG1

6.83e-0510262GO:0072310
GeneOntologyBiologicalProcesspodocyte development

NOTCH2 JAG1

6.83e-0510262GO:0072015
GeneOntologyBiologicalProcessNotch signaling pathway

JAG2 FAT4 NOTCH2 JAG1

1.31e-04210264GO:0007219
GeneOntologyBiologicalProcessinner ear receptor cell differentiation

JAG2 FAT4 JAG1

2.35e-0496263GO:0060113
GeneOntologyBiologicalProcesssensory organ development

JAG2 FAT4 USP45 RS1 NOTCH2 JAG1

2.42e-04730266GO:0007423
GeneOntologyBiologicalProcesspulmonary valve morphogenesis

NOTCH2 JAG1

2.86e-0420262GO:0003184
GeneOntologyBiologicalProcessmechanoreceptor differentiation

JAG2 FAT4 JAG1

2.98e-04104263GO:0042490
GeneOntologyBiologicalProcesspodocyte differentiation

NOTCH2 JAG1

3.48e-0422262GO:0072112
GeneOntologyBiologicalProcessglomerular epithelial cell differentiation

NOTCH2 JAG1

3.48e-0422262GO:0072311
GeneOntologyBiologicalProcessrenal filtration cell differentiation

NOTCH2 JAG1

3.48e-0422262GO:0061318
GeneOntologyBiologicalProcessnephron tubule development

FAT4 NOTCH2 JAG1

3.51e-04110263GO:0072080
GeneOntologyBiologicalProcessglomerular epithelium development

NOTCH2 JAG1

3.80e-0423262GO:0072010
GeneOntologyBiologicalProcessrenal tubule development

FAT4 NOTCH2 JAG1

4.10e-04116263GO:0061326
GeneOntologyBiologicalProcesspulmonary valve development

NOTCH2 JAG1

4.15e-0424262GO:0003177
GeneOntologyBiologicalProcessnephron epithelium development

FAT4 NOTCH2 JAG1

5.47e-04128263GO:0072009
GeneOntologyBiologicalProcesskidney epithelium development

FAT4 NOTCH2 JAG1

1.08e-03162263GO:0072073
GeneOntologyBiologicalProcesscamera-type eye morphogenesis

RS1 NOTCH2 JAG1

1.27e-03171263GO:0048593
GeneOntologyBiologicalProcessnephron development

FAT4 NOTCH2 JAG1

1.33e-03174263GO:0072006
MousePhenodecreased kidney cell proliferation

FAT4 NOTCH2

6.96e-059202MP:0011441
MousePhenoincreased cochlear inner hair cell number

JAG2 JAG1

1.75e-0414202MP:0004395
MousePhenoabnormal bile duct development

NOTCH2 JAG1

2.02e-0415202MP:0002929
DomainhEGF

JAG2 FAT4 NOTCH2 JAG1

6.92e-0828274PF12661
DomainEGF

JAG2 ITGBL1 FAT4 ATRNL1 NOTCH2 JAG1

8.83e-07235276SM00181
DomainEGF-like_dom

JAG2 ITGBL1 FAT4 ATRNL1 NOTCH2 JAG1

1.24e-06249276IPR000742
DomainEGF_1

JAG2 ITGBL1 FAT4 ATRNL1 NOTCH2 JAG1

1.42e-06255276PS00022
DomainEGF_extracell

JAG2 ITGBL1 ATRNL1 JAG1

1.60e-0660274IPR013111
DomainEGF_2

JAG2 ITGBL1 ATRNL1 JAG1

1.60e-0660274PF07974
DomainEGF_2

JAG2 ITGBL1 FAT4 ATRNL1 NOTCH2 JAG1

1.78e-06265276PS01186
DomainJagged/Serrate

JAG2 JAG1

2.01e-062272IPR026219
DomainEGF_CA

JAG2 FAT4 NOTCH2 JAG1

6.78e-0686274PF07645
DomainEGF_Ca-bd_CS

JAG2 FAT4 NOTCH2 JAG1

1.09e-0597274IPR018097
DomainEGF_CA

JAG2 FAT4 NOTCH2 JAG1

1.19e-0599274PS01187
DomainDSL

JAG2 JAG1

1.21e-054272PF01414
DomainDSL

JAG2 JAG1

1.21e-054272SM00051
DomainASX_HYDROXYL

JAG2 FAT4 NOTCH2 JAG1

1.24e-05100274PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

JAG2 FAT4 NOTCH2 JAG1

1.56e-05106274IPR000152
DomainEGF_3

JAG2 FAT4 ATRNL1 NOTCH2 JAG1

1.95e-05235275PS50026
DomainDSL

JAG2 JAG1

2.01e-055272IPR001774
DomainDSL

JAG2 JAG1

2.01e-055272PS51051
DomainNotch_ligand_N

JAG2 JAG1

2.01e-055272IPR011651
DomainMNNL

JAG2 JAG1

2.01e-055272PF07657
DomainEGF_CA

JAG2 FAT4 NOTCH2 JAG1

2.71e-05122274SM00179
DomainEGF-like_Ca-bd_dom

JAG2 FAT4 NOTCH2 JAG1

2.89e-05124274IPR001881
DomainEGF-like_CS

JAG2 FAT4 ATRNL1 NOTCH2 JAG1

3.22e-05261275IPR013032
DomainGrowth_fac_rcpt_

JAG2 FAT4 NOTCH2 JAG1

7.08e-05156274IPR009030
DomainGRAM

TBC1D8 TBC1D8B

2.39e-0416272SM00568
DomainVWC_out

JAG2 JAG1

3.39e-0419272SM00215
DomainGRAM

TBC1D8 TBC1D8B

4.57e-0422272PF02893
DomainGRAM

TBC1D8 TBC1D8B

4.57e-0422272IPR004182
DomainEGF

JAG2 NOTCH2 JAG1

7.79e-04126273PF00008
DomainVWC

JAG2 JAG1

1.37e-0338272SM00214
DomainKRAB

ZNF561 ZNF214 ZNF556 ZNF283

1.64e-03358274PS50805
DomainKRAB

ZNF561 ZNF214 ZNF556 ZNF283

1.64e-03358274PF01352
DomainVWF_dom

JAG2 JAG1

1.67e-0342272IPR001007
DomainKRAB

ZNF561 ZNF214 ZNF556 ZNF283

1.84e-03369274SM00349
DomainKRAB

ZNF561 ZNF214 ZNF556 ZNF283

1.85e-03370274IPR001909
DomainTBC

TBC1D8 TBC1D8B

2.27e-0349272SM00164
DomainRabGAP-TBC

TBC1D8 TBC1D8B

2.65e-0353272PF00566
DomainTBC_RABGAP

TBC1D8 TBC1D8B

2.85e-0355272PS50086
DomainRab-GTPase-TBC_dom

TBC1D8 TBC1D8B

2.85e-0355272IPR000195
DomainC_TYPE_LECTIN_1

CLEC4M ATRNL1

5.93e-0380272PS00615
DomainLectin_C

CLEC4M ATRNL1

6.52e-0384272PF00059
DomainCLECT

CLEC4M ATRNL1

6.52e-0384272SM00034
DomainC_TYPE_LECTIN_2

CLEC4M ATRNL1

6.67e-0385272PS50041
DomainC-type_lectin-like

CLEC4M ATRNL1

6.83e-0386272IPR001304
Domain-

CLEC4M ATRNL1

8.61e-03972723.10.100.10
DomainC-type_lectin-like/link

CLEC4M ATRNL1

8.96e-0399272IPR016186
Domainzf-C2H2_6

ZNF561 ZNF556 ZNF283

1.02e-02314273PF13912
DomainCTDL_fold

CLEC4M ATRNL1

1.04e-02107272IPR016187
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

JAG2 NOTCH2 JAG1

4.96e-0713183M47423
PathwayREACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

JAG2 NOTCH2 JAG1

2.65e-0622183M27210
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

JAG2 NOTCH2 JAG1

5.02e-0627183M39545
PathwayREACTOME_SIGNALING_BY_NOTCH2

JAG2 NOTCH2 JAG1

9.31e-0633183M604
PathwayWP_NOTCH_SIGNALING_WP268

JAG2 NOTCH2 JAG1

2.40e-0545183M39571
PathwayWP_NOTCH_SIGNALING_PATHWAY

JAG2 NOTCH2 JAG1

2.56e-0546183MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

JAG2 NOTCH2 JAG1

2.74e-0547183M7946
PathwayREACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT

JAG2 JAG1

3.22e-057182M27199
PathwayPID_NOTCH_PATHWAY

JAG2 NOTCH2 JAG1

5.43e-0559183M17
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_LIGAND_UBIQUITYLATION

JAG2 JAG1

5.51e-059182M47866
PathwayWP_NOTCH_SIGNALING_WP61

JAG2 NOTCH2 JAG1

6.01e-0561183M39540
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH2 JAG1

1.01e-0412182M47532
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

JAG2 NOTCH2 JAG1

1.45e-0482183MM15922
PathwayREACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER

JAG2 JAG1

1.60e-0415182M27202
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

JAG2 JAG1

1.83e-0416182M47424
PathwayWP_NOTCH1_REGULATION_OF_ENDOTHELIAL_CELL_CALCIFICATION

JAG2 JAG1

2.07e-0417182M39389
PathwayWP_NEPHROGENESIS

NOTCH2 JAG1

2.33e-0418182M40045
PathwayREACTOME_SIGNALING_BY_NOTCH3

JAG2 JAG1

2.60e-0419182MM15594
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

JAG2 NOTCH2 JAG1

4.26e-04118183M39852
PathwayREACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

JAG2 JAG1

4.54e-0425182M27879
PathwayREACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS

JAG2 JAG1

7.01e-0431182M592
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

JAG2 NOTCH2 JAG1

1.05e-03161183M39770
PathwayREACTOME_SIGNALING_BY_NOTCH

JAG2 JAG1

1.11e-0339182MM14604
PathwayREACTOME_SIGNALING_BY_NOTCH3

JAG2 JAG1

1.75e-0349182M618
PathwayREACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER

JAG2 JAG1

2.44e-0358182M29616
PathwayREACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS

JAG2 ZMYM2 SEC31A JAG1

2.46e-03464184M27547
PathwayWP_MARKERS_OF_KIDNEY_CELL_LINEAGE

FAT4 JAG1

2.52e-0359182M46460
PathwayREACTOME_SIGNALING_BY_NOTCH

JAG2 NOTCH2 JAG1

3.53e-03246183M10189
PathwayREACTOME_SIGNALING_BY_NOTCH1

JAG2 JAG1

3.94e-0374182M616
PathwayREACTOME_SIGNALING_BY_NOTCH4

NOTCH2 JAG1

4.81e-0382182M594
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ITGBL1 ZNF561 ZNF214 ZNF556 NOTCH2 JAG1

5.89e-031387186M734
Pubmed

Notch signaling drives multiple myeloma induced osteoclastogenesis.

JAG2 NOTCH2 JAG1

4.17e-10327325257302
Pubmed

Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse.

JAG2 NOTCH2 JAG1

1.67e-09427324398584
Pubmed

Hepatocyte nuclear factor 1β controls nephron tubular development.

JAG2 VIL1 NOTCH2 JAG1

2.52e-092327423362349
Pubmed

Functional diversity of notch family genes in fetal lung development.

JAG2 NOTCH2 JAG1

4.17e-09527315064243
Pubmed

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.

JAG2 NOTCH2 JAG1

8.33e-09627310958687
Pubmed

Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

JAG2 NOTCH2 JAG1

1.46e-08727310383933
Pubmed

Human ligands of the Notch receptor.

JAG2 NOTCH2 JAG1

1.46e-08727310079256
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

JAG2 NOTCH2 JAG1

1.46e-08727312846471
Pubmed

P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis.

JAG2 NOTCH2 JAG1

2.33e-08827322652674
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

JAG2 NOTCH2 JAG1

2.33e-0882739858718
Pubmed

Notch/Delta expression in the developing mouse lung.

JAG2 NOTCH2 JAG1

2.33e-08827311044610
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

JAG2 NOTCH2 JAG1

3.49e-08927311118901
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

JAG2 NOTCH2 JAG1

3.49e-08927316245338
Pubmed

Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress.

JAG2 NOTCH2 JAG1

4.99e-081027326542370
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

JAG2 NOTCH2 JAG1

4.99e-081027323665443
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

JAG2 NOTCH2 JAG1

6.86e-081127310878608
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

JAG2 NOTCH2 JAG1

6.86e-081127312866128
Pubmed

p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis.

JAG2 NOTCH2 JAG1

9.14e-081227326527653
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

JAG2 NOTCH2 JAG1

9.14e-081227315465494
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

JAG2 NOTCH2 JAG1

1.19e-071327311578869
Pubmed

Jagged1 is Essential for Radial Glial Maintenance in the Cortical Proliferative Zone.

JAG2 NOTCH2 JAG1

1.19e-071327331202705
Pubmed

Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation.

JAG2 NOTCH2 JAG1

1.19e-071327311171333
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

JAG2 NOTCH2 JAG1

1.51e-071427314757642
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

JAG2 NOTCH2 JAG1

1.89e-071527312971992
Pubmed

Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.

JAG2 NOTCH2 JAG1

1.89e-071527312167404
Pubmed

COUP-TFI controls Notch regulation of hair cell and support cell differentiation.

JAG2 NOTCH2 JAG1

1.89e-071527316914494
Pubmed

Notch gene expression during pancreatic organogenesis.

JAG2 NOTCH2 JAG1

2.32e-071627310842072
Pubmed

The Cellular Prion Protein Controls Notch Signaling in Neural Stem/Progenitor Cells.

JAG2 NOTCH2 JAG1

2.32e-071627327641601
Pubmed

Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice.

JAG2 NOTCH2 JAG1

2.32e-071627332161758
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

JAG2 NOTCH2 JAG1

2.32e-071627312617809
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

JAG2 NOTCH2 JAG1

2.32e-071627317273555
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

JAG2 NOTCH2 JAG1

2.82e-071727318694942
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

JAG2 NOTCH2 JAG1

2.82e-071727315821257
Pubmed

Notch Signaling Pathway in Tooth Shape Variations throughout Evolution.

JAG2 NOTCH2 JAG1

3.38e-071827336899896
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

JAG2 NOTCH2 JAG1

3.38e-071827318093989
Pubmed

Lunatic fringe null female mice are infertile due to defects in meiotic maturation.

JAG2 NOTCH2 JAG1

3.38e-071827315659488
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

JAG2 NOTCH2 JAG1

3.38e-071827315689374
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

JAG2 NOTCH2 JAG1

4.01e-071927316518823
Pubmed

Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development.

JAG2 NOTCH2 JAG1

4.01e-071927321302255
Pubmed

Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.

JAG2 NOTCH2 JAG1

5.50e-072127328656980
Pubmed

Conversion of biliary system to pancreatic tissue in Hes1-deficient mice.

JAG2 NOTCH2 JAG1

5.50e-072127314702043
Pubmed

FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development.

JAG2 NOTCH2 JAG1

5.50e-072127314651921
Pubmed

Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool.

JAG2 JAG1

5.80e-07227238750026
Pubmed

Clinical features, outcomes, and genetic analysis in Korean children with Alagille syndrome.

NOTCH2 JAG1

5.80e-07227225676721
Pubmed

Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction.

JAG2 JAG1

5.80e-07227211549580
Pubmed

The Notch2-Jagged1 interaction mediates stem cell factor signaling in erythropoiesis.

NOTCH2 JAG1

5.80e-07227220829885
Pubmed

Renal involvement and the role of Notch signalling in Alagille syndrome.

NOTCH2 JAG1

5.80e-07227223752887
Pubmed

Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable.

JAG2 JAG1

5.80e-07227228111308
Pubmed

NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma.

JAG2 JAG1

5.80e-07227224708907
Pubmed

Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage.

NOTCH2 JAG1

5.80e-07227217366661
Pubmed

Activated NOTCH2 is overexpressed in hepatoblastomas: an immunohistochemical study.

NOTCH2 JAG1

5.80e-07227221639801
Pubmed

Notch signaling regulates bile duct morphogenesis in mice.

NOTCH2 JAG1

5.80e-07227218365007
Pubmed

A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency.

NOTCH2 JAG1

5.80e-07227211861489
Pubmed

Evaluation of the Genetic Association and Expressions of Notch-2 /Jagged-1 in Patients with Type 2 Diabetes Mellitus.

NOTCH2 JAG1

5.80e-07227234219868
Pubmed

Effects of chlorpyrifos exposure on kidney Notch2-Jagged1 pathway of early prenatal embryo.

NOTCH2 JAG1

5.80e-07227221328691
Pubmed

NOTCH2 participates in Jagged1-induced osteogenic differentiation in human periodontal ligament cells.

NOTCH2 JAG1

5.80e-07227232770090
Pubmed

Alagille syndrome mutation update: Comprehensive overview of JAG1 and NOTCH2 mutation frequencies and insight into missense variant classification.

NOTCH2 JAG1

5.80e-07227231343788
Pubmed

Notch signaling in kidney development.

JAG2 NOTCH2

5.80e-07227212496659
Pubmed

Alagille Syndrome

NOTCH2 JAG1

5.80e-07227220301450
Pubmed

Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.

JAG2 NOTCH2 JAG1

6.36e-072227321750033
Pubmed

Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice.

JAG2 NOTCH2 JAG1

7.31e-072327323386589
Pubmed

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.

JAG2 NOTCH2 JAG1

7.31e-072327314701881
Pubmed

Rbpj regulates development of prosensory cells in the mammalian inner ear.

JAG2 NOTCH2 JAG1

8.35e-072427321420948
Pubmed

Notch signaling controls liver development by regulating biliary differentiation.

JAG2 NOTCH2 JAG1

1.07e-062627319369401
Pubmed

A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice.

JAG2 NOTCH2 JAG1

1.21e-062727329956664
Pubmed

Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.

JAG2 NOTCH2 JAG1

1.50e-062927325535917
Pubmed

Notch signaling in stomach epithelial stem cell homeostasis.

JAG2 NOTCH2 JAG1

1.50e-062927321402740
Pubmed

Notch signaling regulates ovarian follicle formation and coordinates follicular growth.

JAG2 NOTCH2 JAG1

1.67e-063027324552588
Pubmed

p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation.

JAG2 NOTCH2 JAG1

1.67e-063027316524929
Pubmed

β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.

JAG2 JAG1

1.74e-06327224907271
Pubmed

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.

JAG2 NOTCH2

1.74e-06327228572448
Pubmed

miR-598 inhibits metastasis in colorectal cancer by suppressing JAG1/Notch2 pathway stimulating EMT.

NOTCH2 JAG1

1.74e-06327228161537
Pubmed

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.

JAG2 JAG1

1.74e-06327223530123
Pubmed

The Notch-mediated circuitry in the evolution and generation of new cell lineages: the tooth model.

JAG2 NOTCH2

1.74e-06327237330998
Pubmed

Notch Signaling Regulates Differentiation and Steroidogenesis in Female Mouse Ovarian Granulosa Cells.

NOTCH2 JAG1

1.74e-06327229126263
Pubmed

Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.

JAG2 NOTCH2

1.74e-06327218458347
Pubmed

Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells.

JAG2 JAG1

1.74e-0632729716576
Pubmed

Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice.

JAG2 JAG1

1.74e-06327211841846
Pubmed

Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells.

NOTCH2 JAG1

1.74e-06327214726396
Pubmed

Absence of NOTCH2 and Hey2 mutations in a familial Alagille syndrome case with a novel frameshift mutation in JAG1.

NOTCH2 JAG1

1.74e-06327218266235
Pubmed

Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency.

JAG2 JAG1

1.74e-06327224191040
Pubmed

ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling.

JAG2 NOTCH2 JAG1

1.85e-063127337573008
Pubmed

Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.

JAG2 NOTCH2 JAG1

2.24e-063327316000382
Pubmed

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.

JAG2 NOTCH2 JAG1

2.46e-063427321311046
Pubmed

Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.

JAG2 NOTCH2 JAG1

2.69e-063527321252157
Pubmed

The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.

JAG2 NOTCH2 JAG1

2.69e-063527328402857
Pubmed

Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification.

JAG2 NOTCH2 JAG1

3.19e-063727324673559
Pubmed

Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells.

JAG2 NOTCH2 JAG1

3.19e-063727327631609
Pubmed

FGF10 signaling controls stomach morphogenesis.

JAG2 NOTCH2 JAG1

3.46e-063827317196193
Pubmed

Activation of Notch signaling in human tongue carcinoma.

JAG2 JAG1

3.48e-06427220819128
Pubmed

Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws.

JAG2 JAG1

3.48e-06427220040020
Pubmed

A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea.

JAG2 JAG1

3.48e-06427210837254
Pubmed

Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate.

JAG2 JAG1

3.48e-06427220602435
Pubmed

Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes.

NOTCH2 JAG1

3.48e-06427222390640
Pubmed

Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.

NOTCH2 JAG1

3.48e-06427230226866
Pubmed

The Notch signalling pathway in hair growth.

JAG2 JAG1

3.48e-0642729858728
Pubmed

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods.

NOTCH2 JAG1

3.48e-06427210551863
Pubmed

Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.

JAG2 JAG1

3.48e-0642729315665
Pubmed

Splicing factor ESRP1 derived circ_0068162 promotes the progression of oral squamous cell carcinoma via the miR-186/JAG axis.

JAG2 JAG1

3.48e-06427237966490
Pubmed

Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear.

NOTCH2 JAG1

3.48e-06427228566723
InteractionJAG1 interactions

JAG2 NOTCH2 JAG1

1.97e-0541263int:JAG1
CytobandEnsembl 112 genes in cytogenetic band chr19p13

ZNF561 CLEC4M ZNF556

1.12e-02797273chr19p13
GeneFamilyWD repeat domain containing|GRAM domain containing|BEACH domain containing

TBC1D8 TBC1D8B

1.20e-04132321146
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF561 ZNF214 ZNF556 ZNF283

1.20e-0271823428
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

JAG2 NOTCH2 JAG1

5.41e-0716273M2207
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

JAG2 NOTCH2 JAG1

5.41e-0716273MM1296
CoexpressionBRUNEAU_HEART_GREAT_VESSELS_AND_VALVULOGENESIS

NOTCH2 JAG1

2.85e-058272M9884
CoexpressionSASAKI_TARGETS_OF_TP73_AND_TP63

JAG2 JAG1

6.70e-0512272M17374
ToppCellTCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

TBC1D8 ZNF561 NOTCH2 JAG1

6.14e-062002741fa8422fd820d21e285a7e7c4c6fbd8b7277d2af
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ZNF556 TBC1D8B ZNF283

7.33e-051352739f9d0787a2e99207a9caa88a85565189ab8b940a
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ITGBL1 FAT4 ATRNL1

1.30e-04164273e3983f655cdba308fb192182829f17bef99ce0ba
ToppCelldroplet-Heart-nan-24m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 FAT4 JAG1

1.38e-04167273a35ace2c722936d2a3e1f0826e5b6ec6b1340d2b
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ZNF214 USP45 ATRNL1

1.40e-0416827353a982869dbf14f6a948589be9f2f3df3b9a7e97
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ITGBL1 FAT4 ATRNL1

1.53e-041732731f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ITGBL1 FAT4 ATRNL1

1.63e-04177273b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 FAT4 JAG1

1.66e-041782735f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

JAG2 FAT4 JAG1

1.69e-041792732a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ITGBL1 FAT4 ATRNL1

1.72e-0418027301f2e5d96016823482f89ba503d007d4bd88eeac
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ITGBL1 FAT4 ATRNL1

1.74e-04181273d7e04e0ca549eac6d9b1192b6578f9b54943d54f
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 FAT4 JAG1

1.86e-04185273f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

JAG2 FAT4 JAG1

1.92e-0418727340ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellMesenchymal-myofibroblast_cell|World / Lineage, Cell type, age group and donor

ITGBL1 FAT4 ATRNL1

1.98e-0418927344e37f88137bb249933eb615235b2cf2ae7f3925
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 ATRNL1 NOTCH2

2.01e-04190273048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VIL1 ZC2HC1A JAG1

2.01e-041902733cf464664d6aa22b212e60b70885953887e92483
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 ATRNL1 NOTCH2

2.01e-041902731121eb607a984c59fbffe7220837fc178745aa55
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|kidney / Disease (COVID-19 only), tissue and cell type

JAG2 FAT4 JAG1

2.01e-041902731519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

JAG2 FAT4 JAG1

2.04e-041912734b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 FAT4 JAG1

2.04e-04191273b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ITGBL1 FAT4 JAG1

2.11e-04193273cf2461af78f65616ce40d552ee9452295e3895ed
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ITGBL1 FAT4 JAG1

2.11e-04193273e4ea7ce011a80b81b841c907719aa532bed39d2e
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ITGBL1 FAT4 JAG1

2.11e-041932736ef9007c9d18fb775d08fb20cdf954a28d54d7eb
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KIAA1210 ITGBL1 ATRNL1

2.11e-0419327309a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 FAT4 JAG1

2.14e-04194273b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCellcellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

JAG2 FAT4 JAG1

2.17e-0419527375db19c0371320ea5fce1d6de8c1b40b1e6a2e58
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 FAT4 ATRNL1

2.24e-041972739b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 ATRNL1 NOTCH2

2.27e-04198273a860246bcea847249a78fd2e86ed8e04371060db
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

JAG2 FAT4 JAG1

2.31e-041992736a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FAT4 ZC2HC1A ATRNL1

2.31e-0419927338cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ITGBL1 ZC2HC1A ATRNL1

2.34e-042002738988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGBL1 FAT4 ATRNL1

2.34e-04200273fb53be20392a8309a7393774c774a1b1aec6e676
ToppCellLPS_IL1RA-Endothelial-Endothelial-Artery|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

JAG2 FAT4 JAG1

2.34e-04200273ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCellTracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

JAG2 FAT4 JAG1

2.34e-042002735ec31c1be6bcc4124e1489d136570f3de33cc2e9
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

ITGBL1 FAT4 ATRNL1

2.34e-0420027316a3685c41194a0a4a772e4eee372160263480e0
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGBL1 FAT4 ATRNL1

2.34e-0420027358b38f9a484ee94191091a0659ed62ebed2d4a14
Druglead stearate

JAG2 VIL1 NOTCH2 JAG1

2.84e-0684274CID000061258
Drugdienol

JAG2 CLEC4M NOTCH2 JAG1

1.92e-05136274CID000003049
DrugAC1L1GUQ

JAG2 NOTCH2 JAG1

2.81e-0550273CID000003849
DiseaseHepatic ductular hypoplasia

NOTCH2 JAG1

8.06e-072272C2930797
DiseaseAlagille syndrome (is_implicated_in)

NOTCH2 JAG1

8.06e-072272DOID:9245 (is_implicated_in)
DiseaseAlagille Syndrome

NOTCH2 JAG1

8.06e-072272C0085280
DiseaseArteriohepatic dysplasia

NOTCH2 JAG1

8.06e-072272cv:C0085280
DiseaseAlagille Syndrome 2

NOTCH2 JAG1

8.06e-072272C1857761
DiseaseAlagille Syndrome 1

NOTCH2 JAG1

8.06e-072272C1956125
Diseasenephrotic syndrome type 20 (implicated_via_orthology)

TBC1D8 TBC1D8B

4.83e-064272DOID:0070357 (implicated_via_orthology)
DiseaseGlioblastoma

JAG2 NOTCH2 JAG1

5.16e-0579273C0017636
DiseaseGiant Cell Glioblastoma

JAG2 NOTCH2 JAG1

6.20e-0584273C0334588
DiseaseGlioblastoma Multiforme

JAG2 NOTCH2 JAG1

1.42e-04111273C1621958
DiseaseCarcinoma, Pancreatic Ductal

JAG2 JAG1

2.20e-0424272C0887833
DiseaseCongenital Heart Defects

TRRAP JAG1

7.45e-0444272C0018798
DiseaseDiffuse Large B-Cell Lymphoma

SEC31A NOTCH2

1.16e-0355272C0079744
Diseaseneutrophil percentage of leukocytes

TBC1D8 SEC31A CLEC4M ZC2HC1A

2.18e-03610274EFO_0007990
Diseasedilated cardiomyopathy (implicated_via_orthology)

JAG2 JAG1

2.44e-0380272DOID:12930 (implicated_via_orthology)
DiseaseSquamous cell carcinoma of esophagus

FAT4 NOTCH2

3.42e-0395272C0279626
Disease3-hydroxy-1-methylpropylmercapturic acid measurement

KIAA1210 WFDC11 TBC1D8B

3.98e-03352273EFO_0007015

Protein segments in the cluster

PeptideGeneStartEntry
FLCKCLPGYAGSWCE

FAT4

3846

Q6V0I7
YKCLCDAGWVGINCE

NOTCH2

741

Q04721
FYCACDDGWKGKTCH

JAG2

696

Q9Y219
SCTKGCKAVYKAWLC

NALF2

281

O75949
VYCECDKYWKGEACD

ATRNL1

231

Q5VV63
CCSCLWLTYKGKKEG

KIAA1210

46

Q9ULL0
YCGNCYCKAGWHGDK

ITGBL1

201

O95965
YCKAGWHGDKCEFQC

ITGBL1

206

O95965
CGRCDCKAGWYGKKC

ITGBL1

296

O95965
CRCQYGWQGLYCDKC

JAG1

251

P78504
VNDFYCDCKNGWKGK

JAG1

686

P78504
CDVDNYWICKKPAAC

CLEC4M

381

Q9H2X3
GYSGWKLCDCKNCGE

ZNF561

111

Q8N587
FVLKTQSCCYLWCGK

VIL1

546

P09327
DIWLCLKCGFQGCGK

USP45

81

Q70EL2
FKKELFLSCYWCLGC

TBC1D8B

806

Q0IIM8
AEKLVTYYSCCCWKG

TBC1D8

156

O95759
PYECKQCGKAYCWAT

ZNF556

286

Q9HAH1
RGWCIVGKKQTCPYC

RNF121

261

Q9H920
WYYKAARCDCCKSQG

ZMYM2

761

Q9UBW7
KYPVEWAKFCCECGI

ZC2HC1A

306

Q96GY0
DPWYQKACKCDCQGG

RS1

31

O15537
CYICAGNVEKLVACW

SEC31A

691

O94979
FCFWSKKYKTLCWCG

SLC5A12

546

Q1EHB4
CKYWPACKNGDECAY

ZC3H14

601

Q6PJT7
CACCYEQAWYAKLGG

TRRAP

1146

Q9Y4A5
CKDKNYTCCWTYCGN

WFDC11

61

Q8NEX6
GCKCQYKHIVDWCGC

XYLT2

466

Q9H1B5
CNKCKGIYYWNSRCV

ZNF214

221

Q9UL59
ECKICGKAFCWGYQL

ZNF283

376

Q8N7M2