Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	clathrin-coated vesicle cargo loading	AP3B1 AP3B2	6.90e-05	7	38	2	GO:0035652
GeneOntologyBiologicalProcess	clathrin-coated vesicle cargo loading, AP-3-mediated	AP3B1 AP3B2	6.90e-05	7	38	2	GO:0035654
Domain	DUF4195	ZNF280A ZNF280B ZNF280D	2.86e-08	4	37	3	IPR025243
Domain	DUF4195	ZNF280A ZNF280B ZNF280D	2.86e-08	4	37	3	PF13836
Domain	AP3_beta	AP3B1 AP3B2	3.82e-06	2	37	2	IPR026740
Domain	AP3B1_C	AP3B1 AP3B2	3.82e-06	2	37	2	PF14796
Domain	AP3B1_C	AP3B1 AP3B2	3.82e-06	2	37	2	SM01355
Domain	AP3B_C	AP3B1 AP3B2	3.82e-06	2	37	2	IPR029390
Domain	AP_beta	AP3B1 AP3B2	3.80e-05	5	37	2	IPR026739
Domain	Calpain_III	CAPN3 CAPN6	2.49e-04	12	37	2	IPR022683
Domain	calpain_III	CAPN3 CAPN6	2.49e-04	12	37	2	SM00720
Domain	C2_III	CAPN3 CAPN6	2.49e-04	12	37	2	IPR033883
Domain	Calpain_domain_III	CAPN3 CAPN6	2.94e-04	13	37	2	IPR022682
Domain	Calpain_III	CAPN3 CAPN6	2.94e-04	13	37	2	PF01067
Domain	Calpain_cysteine_protease	CAPN3 CAPN6	3.42e-04	14	37	2	IPR022684
Domain	Clathrin/coatomer_adapt-like_N	AP3B1 AP3B2	3.95e-04	15	37	2	IPR002553
Domain	Adaptin_N	AP3B1 AP3B2	3.95e-04	15	37	2	PF01602
Domain	CysPc	CAPN3 CAPN6	3.95e-04	15	37	2	SM00230
Domain	CALPAIN_CAT	CAPN3 CAPN6	3.95e-04	15	37	2	PS50203
Domain	Peptidase_C2_calpain_cat	CAPN3 CAPN6	3.95e-04	15	37	2	IPR001300
Domain	Peptidase_C2	CAPN3 CAPN6	3.95e-04	15	37	2	PF00648
Domain	ARM-type_fold	IPO8 AP3B1 CWC22 AOPEP AP3B2	5.17e-04	339	37	5	IPR016024
Domain	THIOL_PROTEASE_CYS	CAPN3 CAPN6	1.20e-03	26	37	2	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN3 CAPN6	1.30e-03	27	37	2	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN3 CAPN6	1.30e-03	27	37	2	PS00639
Domain	Pept_cys_AS	CAPN3 CAPN6	1.40e-03	28	37	2	IPR000169
Domain	-	IPO8 AP3B1 AP3B2	9.56e-03	222	37	3	1.25.10.10
Pathway	WP_INTEGRINMEDIATED_CELL_ADHESION	ITGA3 CAPN3 CAPN6	7.53e-04	102	25	3	M39577
Pathway	WP_INTEGRINMEDIATED_CELL_ADHESION	ITGA3 CAPN3 CAPN6	7.53e-04	102	25	3	MM15830
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC4A10 SLC9A5 SLC15A2 SLC2A12	7.58e-04	238	25	4	MM15076
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC4A10 SLC9A5 SLC15A2	8.90e-04	108	25	3	M823
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC4A10 SLC9A5 SLC15A2 SLC2A12	8.97e-04	249	25	4	M5988
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC4A10 SLC9A5 SLC15A2	9.14e-04	109	25	3	MM15074
Pubmed	The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform.	AP3B1 AP3B2	3.48e-06	3	38	2	10930456
Pubmed	Characterization of the cloned full-length and a truncated human target of rapamycin: activity, specificity, and enzyme inhibition as studied by a high capacity assay.	PA2G4 RPS6KB1	3.48e-06	3	38	2	15896331
Pubmed	Regulation of large dense-core vesicle volume and neurotransmitter content mediated by adaptor protein 3.	AP3B1 AP3B2	6.96e-06	4	38	2	16788073
Pubmed	Adaptor protein-3 produces synaptic vesicles that release phasic dopamine.	AP3B1 AP3B2	1.16e-05	5	38	2	37812725
Pubmed	Association analysis between schizophrenia and the AP-3 complex genes.	AP3B1 AP3B2	1.16e-05	5	38	2	19481122
Pubmed	Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.	AP3B1 AP3B2	1.74e-05	6	38	2	15537701
Pubmed	Structure and physiological function of calpains.	CAPN3 CAPN6	2.43e-05	7	38	2	9396712
Pubmed	The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy.	SLC15A2 RPS6KB1	2.43e-05	7	38	2	27553280
Pubmed	Characterization of the adaptor-related protein complex, AP-3.	AP3B1 AP3B2	2.43e-05	7	38	2	9151686
Pubmed	Association of the AP-3 adaptor complex with clathrin.	AP3B1 AP3B2	3.24e-05	8	38	2	9545220
Pubmed	Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord.	CAPN3 CAPN6	3.24e-05	8	38	2	9473662
Pubmed	AP-3 and Rabip4' coordinately regulate spatial distribution of lysosomes.	AP3B1 AP3B2	4.16e-05	9	38	2	23144738
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	MAGI2 SGO2 ZGRF1 CAPN3 CAPN6	4.56e-05	363	38	5	14691545
Pubmed	HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes.	AP3B1 AP3B2	5.20e-05	10	38	2	18076669
Pubmed	Regulation of arrestin-3 phosphorylation by casein kinase II.	AP3B1 AP3B2	5.20e-05	10	38	2	11877451
Pubmed	Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.	AP3B1 AP3B2	7.62e-05	12	38	2	19144828
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	KNTC1 SGO2 UFL1 IPO8 ZNF280D AP3B1 CWC22 PA2G4	1.27e-04	1425	38	8	30948266
Pubmed	Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles.	AP3B1 AP3B2	1.38e-04	16	38	2	23247405
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	FNBP1 ADGRE2 AP3B1 PA2G4 AOPEP RPS6KB1 CEP63	1.52e-04	1084	38	7	11544199
Pubmed	The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.	AP3B1 AP3B2	1.76e-04	18	38	2	21998198
Pubmed	KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.	ERGIC1 PA2G4	2.90e-04	23	38	2	28869606
Pubmed	Substrate specificities and identification of putative substrates of ATM kinase family members.	AP3B1 PA2G4	3.43e-04	25	38	2	10608806
Pubmed	The AP-3 complex: a coat of many colours.	AP3B1 AP3B2	4.32e-04	28	38	2	9714600
Pubmed	Defining the molecular character of the developing and adult kidney podocyte.	MAGI2 ITGA3	8.40e-04	39	38	2	21931791
Cytoband	22q11.22	ZNF280A ZNF280B	1.67e-04	23	38	2	22q11.22
Cytoband	15q21.3	ZNF280D WDR72	3.90e-04	35	38	2	15q21.3
Cytoband	12q24.31	AACS KNTC1	2.02e-03	80	38	2	12q24.31
GeneFamily	C2 domain containing\|Calpains	CAPN3 CAPN6	1.34e-04	15	21	2	975
GeneFamily	Solute carriers	SLC4A10 SLC9A5 SLC15A2 SLC2A12	1.00e-03	395	21	4	752
Disease	intellectual disability (implicated_via_orthology)	ZNF280A ZNF280B ZNF280D CAPN3	2.66e-06	75	38	4	DOID:1059 (implicated_via_orthology)
Disease	triacylglycerol 46:0 measurement	CWC22 WDR72	1.68e-04	15	38	2	EFO_0010400
Disease	autism spectrum disorder (implicated_via_orthology)	ZNF280A ZNF280B ZNF280D	9.91e-04	152	38	3	DOID:0060041 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	DCHS2 SLC15A2 CAPN3	2.67e-03	215	38	3	DOID:9970 (implicated_via_orthology)
Disease	wheezing	MAGI2 AP3B1	3.19e-03	65	38	2	EFO_0009715
Disease	urinary metabolite measurement	AACS ZKSCAN5 RPS6KB1	3.85e-03	245	38	3	EFO_0005116
Disease	testosterone measurement	DCHS2 ZNF280D CWC22 ZKSCAN5 AOPEP WDR72	5.42e-03	1275	38	6	EFO_0004908
Disease	uric acid measurement	MED4 SLC15A2 ZKSCAN5 WDR72	7.65e-03	610	38	4	EFO_0004761

Protein segments in the cluster

Peptide	Gene	Start	Entry
DQVLLQHMKDHHKPG	ZNF280A	376	P59817
QVLLQHMKDHHKPGE	ZNF280B	386	Q86YH2
HVLLQHMKDNHKPGE	ZNF280D	401	Q6N043
EHNHMEKLQQVVKGL	AACS	216	Q86V21
LEPEKQMLLHETHQG	ADGRE2	421	Q9UHX3
IKHGLNPEKIFMQVH	AOPEP	571	Q8N6M6
KKLLQMQPAQHGEII	AP3B1	466	O00203
KKLLQMQPAQHGEII	AP3B2	471	Q13367
MQPAQHGEIIKHLAK	AP3B2	476	Q13367
FMSHHQEELVPKQPQ	SLC2A12	576	Q8TD20
PIEGMLSHQLKQHVI	PA2G4	181	Q9UQ80
KLQQHNMPHTELGTK	MAGI2	386	Q86UL8
LQGKPQSHELKVHEM	NUDCD3	316	Q8IVD9
QEMHIDLENKHGDPK	CWC22	806	Q9HCG8
HMDNGLVPQKIVSVH	HLCS	6	P50747
MNITVKNDPGHHIIE	ITGA3	106	P26006
HEVGHIDNSMKIPLN	ERGIC1	96	Q969X5
PENIMLNHQGHVKLT	RPS6KB1	221	P23443
EQLVKQHLEMDHPKV	KNTC1	816	P50748
QHLEMDHPKVKLLQE	KNTC1	821	P50748
QGKIHHEMQVLEKEV	MED4	86	Q9NPJ6
KELHVKVLEGQPVNM	DCHS2	1301	Q6V1P9
QEIKQEIHQVLMDHG	CCNYL3	251	P0C7X3
HTHIPNIFQKIQEME	FNBP1	206	Q96RU3
GMLHQQVEEHEKIKQ	CEP63	76	Q96MT8
VPEDGHKVIMSLQQK	CAPN6	391	Q9Y6Q1
IYEVPKEMHGNKQHL	CAPN3	506	P20807
HIPHIQGNMIKLETK	SLC15A2	711	Q16348
KQMKPHIQNISEDVI	IPO8	341	O15397
LLKPDKEIEHQGNHM	RBP5	36	P82980
VDNPINIVLQEKMKH	SAMD3	376	Q8N6K7
PNHIEHVVLNQKNMT	PHF12	316	Q96QT6
QQQELQPLMGHKDHT	SLC9A5	861	Q14940
EIQNVLGVKHGHDMQ	SGO2	781	Q562F6
QLNLVHMHPEKGQEL	UNC80	2071	Q8N2C7
HMHPEKGQELIQKQV	UNC80	2076	Q8N2C7
MKQRHEKGPPHQQER	SLC4A10	301	Q6U841
EVQQHMKSLGKIPVN	WDR72	996	Q3MJ13
KSKGINMNLHIPHIQ	ZGRF1	681	Q86YA3
HQKAEKEMKNNPVHL	UFL1	381	O94874
LIEHQVLHMGQKNEK	ZKSCAN5	676	Q9Y2L8