Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	microfilament motor activity	MYH1 MYH2 MYH4 MYH9 MYO5B MYO5C	6.23e-09	38	76	6	GO:0000146
GeneOntologyMolecularFunction	calmodulin binding	MYH1 MYH2 MYH4 SLC8A1 MYH9 MYO5B SCN2A RYR2 RYR3 MYO5C	1.66e-08	230	76	10	GO:0005516
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH1 MYH2 MYH4 MYH9 MYO5B MYO5C	5.85e-06	118	76	6	GO:0003774
GeneOntologyMolecularFunction	nicotinic acid receptor activity	HCAR3 HCAR2	1.43e-05	2	76	2	GO:0070553
GeneOntologyMolecularFunction	ATP-dependent activity	MYH1 MYH2 MYH4 MYH9 MYO5B ABCC8 CHD5 FIGNL2 NAV3 DICER1 MYO5C	1.98e-05	614	76	11	GO:0140657
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR2 RYR3 MCOLN2	4.15e-05	18	76	3	GO:0015278
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR2 RYR3	8.54e-05	4	76	2	GO:0005219
GeneOntologyMolecularFunction	channel activity	TPTE GJD2 NALCN ABCC8 SCN2A GJC2 RYR2 RYR3 MCOLN2	1.67e-04	525	76	9	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	TPTE GJD2 NALCN ABCC8 SCN2A GJC2 RYR2 RYR3 MCOLN2	1.69e-04	526	76	9	GO:0022803
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR2 RYR3	2.12e-04	6	76	2	GO:0048763
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR2 RYR3 MCOLN2	2.21e-04	31	76	3	GO:0099604
GeneOntologyMolecularFunction	actin filament binding	MYH1 MYH2 MYH4 MYH9 MYO5B MYO5C	2.28e-04	227	76	6	GO:0051015
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR2 RYR3 MCOLN2	2.66e-04	33	76	3	GO:0005217
GeneOntologyMolecularFunction	sulfur compound binding	SELP BMP7 ACACA LTC4S DHTKD1 RYR2	1.45e-03	323	76	6	GO:1901681
GeneOntologyMolecularFunction	transmembrane transporter activity	TPTE SLC8A1 GJD2 SLC16A5 NALCN ABCC8 SCN2A GJC2 SPNS3 RYR2 RYR3 MCOLN2	1.59e-03	1180	76	12	GO:0022857
GeneOntologyMolecularFunction	monoatomic ion channel activity	TPTE NALCN ABCC8 SCN2A RYR2 RYR3 MCOLN2	1.81e-03	459	76	7	GO:0005216
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC8A1 NALCN ABCC8 SCN2A RYR2 RYR3 MCOLN2	1.95e-03	465	76	7	GO:0046873
GeneOntologyMolecularFunction	monoatomic cation channel activity	NALCN ABCC8 SCN2A RYR2 RYR3 MCOLN2	1.96e-03	343	76	6	GO:0005261
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	ABCC8 RYR2 RYR3 MCOLN2	2.01e-03	140	76	4	GO:0099094
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	SLC8A1 RYR2 RYR3 MCOLN2	2.64e-03	151	76	4	GO:0015085
GeneOntologyBiologicalProcess	actin filament-based movement	MYH2 MYH4 MYH9 MYO5B SCN2A RYR2 MYO5C	1.53e-06	153	76	7	GO:0030048
GeneOntologyBiologicalProcess	cellular response to caffeine	SLC8A1 RYR2 RYR3	7.77e-06	11	76	3	GO:0071313
GeneOntologyBiologicalProcess	cellular response to purine-containing compound	SLC8A1 RYR2 RYR3	1.70e-05	14	76	3	GO:0071415
GeneOntologyBiologicalProcess	response to caffeine	SLC8A1 RYR2 RYR3	6.10e-05	21	76	3	GO:0031000
GeneOntologyBiologicalProcess	negative regulation of blood-brain barrier permeability	IFNB1 ABCC8	8.00e-05	4	76	2	GO:1905604
GeneOntologyBiologicalProcess	positive regulation of adiponectin secretion	HCAR3 HCAR2	8.00e-05	4	76	2	GO:0070165
GeneOntologyBiologicalProcess	negative regulation of cytosolic calcium ion concentration	SLC8A1 RYR2 RYR3	1.04e-04	25	76	3	GO:0051481
GeneOntologyBiologicalProcess	positive regulation of the force of heart contraction	SLC8A1 RYR2	1.33e-04	5	76	2	GO:0098735
GeneOntologyBiologicalProcess	spermatogonial cell division	ZNF449 DICER1	1.33e-04	5	76	2	GO:0007284
GeneOntologyBiologicalProcess	muscle system process	MYH1 MYH2 MYH4 SLC8A1 ABCC8 SCN2A CAMTA2 RYR2 RYR3	1.78e-04	547	76	9	GO:0003012
GeneOntologyCellularComponent	myosin complex	MYH1 MYH2 MYH4 MYH9 MYO5B MYO5C	8.54e-08	59	78	6	GO:0016459
GeneOntologyCellularComponent	myosin filament	MYH1 MYH2 MYH4 MYH9	2.14e-06	25	78	4	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH1 MYH2 MYH4 MYH9	3.43e-06	28	78	4	GO:0016460
GeneOntologyCellularComponent	muscle myosin complex	MYH1 MYH2 MYH4	2.70e-05	16	78	3	GO:0005859
GeneOntologyCellularComponent	actomyosin contractile ring	MYH2 MYH9	2.85e-04	7	78	2	GO:0005826
GeneOntologyCellularComponent	sarcomere	MYH1 MYH2 MYH4 SLC8A1 RYR2 RYR3	3.37e-04	249	78	6	GO:0030017
GeneOntologyCellularComponent	cell-cell junction	MYH1 MYH2 SLC8A1 MYH9 GJD2 PTPRM SCN2A GJC2 CDH13	3.49e-04	591	78	9	GO:0005911
GeneOntologyCellularComponent	myofibril	MYH1 MYH2 MYH4 SLC8A1 RYR2 RYR3	5.49e-04	273	78	6	GO:0030016
GeneOntologyCellularComponent	sarcolemma	SLC8A1 ABCC8 SCN2A RYR2 RYR3	7.26e-04	190	78	5	GO:0042383
GeneOntologyCellularComponent	contractile muscle fiber	MYH1 MYH2 MYH4 SLC8A1 RYR2 RYR3	7.53e-04	290	78	6	GO:0043292
GeneOntologyCellularComponent	A band	MYH1 MYH2 RYR2	9.68e-04	52	78	3	GO:0031672
GeneOntologyCellularComponent	contractile ring	MYH2 MYH9	1.21e-03	14	78	2	GO:0070938
GeneOntologyCellularComponent	paranode region of axon	SCN2A GJC2	1.80e-03	17	78	2	GO:0033270
GeneOntologyCellularComponent	intercalated disc	MYH1 SLC8A1 SCN2A	2.10e-03	68	78	3	GO:0014704
GeneOntologyCellularComponent	node of Ranvier	SCN2A BCAN	2.50e-03	20	78	2	GO:0033268
Domain	IQ	MYH1 MYH2 MYH4 MYH9 MYO5B SCN2A CAMTA2 MYO5C	1.31e-09	81	76	8	SM00015
Domain	Myosin_N	MYH1 MYH2 MYH4 MYH9 MYO5C	2.84e-09	15	76	5	PF02736
Domain	Myosin_N	MYH1 MYH2 MYH4 MYH9 MYO5C	2.84e-09	15	76	5	IPR004009
Domain	IQ_motif_EF-hand-BS	MYH1 MYH2 MYH4 MYH9 MYO5B SCN2A CAMTA2 MYO5C	3.06e-09	90	76	8	IPR000048
Domain	IQ	MYH1 MYH2 MYH4 MYH9 MYO5B SCN2A CAMTA2 MYO5C	3.98e-09	93	76	8	PS50096
Domain	Myosin_head_motor_dom	MYH1 MYH2 MYH4 MYH9 MYO5B MYO5C	9.24e-09	38	76	6	IPR001609
Domain	MYOSIN_MOTOR	MYH1 MYH2 MYH4 MYH9 MYO5B MYO5C	9.24e-09	38	76	6	PS51456
Domain	Myosin_head	MYH1 MYH2 MYH4 MYH9 MYO5B MYO5C	9.24e-09	38	76	6	PF00063
Domain	MYSc	MYH1 MYH2 MYH4 MYH9 MYO5B MYO5C	9.24e-09	38	76	6	SM00242
Domain	Myosin-like_IQ_dom	MYH1 MYH2 MYH4 MYH9 MYO5C	1.09e-08	19	76	5	IPR027401
Domain	-	MYH1 MYH2 MYH4 MYH9 MYO5C	1.09e-08	19	76	5	4.10.270.10
Domain	IQ	MYH1 MYH2 MYH4 MYH9 MYO5B CAMTA2 MYO5C	1.50e-08	71	76	7	PF00612
Domain	Myosin_tail_1	MYH1 MYH2 MYH4 MYH9	7.42e-07	18	76	4	PF01576
Domain	Myosin_tail	MYH1 MYH2 MYH4 MYH9	7.42e-07	18	76	4	IPR002928
Domain	Ion_trans_dom	TPTE NALCN SCN2A RYR2 RYR3 MCOLN2	6.99e-06	114	76	6	IPR005821
Domain	Ion_trans	TPTE NALCN SCN2A RYR2 RYR3 MCOLN2	6.99e-06	114	76	6	PF00520
Domain	HCAR2/3_rcpt	HCAR3 HCAR2	1.63e-05	2	76	2	IPR028017
Domain	Ryanrecept_TM4-6	RYR2 RYR3	4.89e-05	3	76	2	IPR009460
Domain	RyR	RYR2 RYR3	4.89e-05	3	76	2	PF02026
Domain	Ryanodine_rcpt	RYR2 RYR3	4.89e-05	3	76	2	IPR003032
Domain	RR_TM4-6	RYR2 RYR3	4.89e-05	3	76	2	PF06459
Domain	Ryan_recept	RYR2 RYR3	4.89e-05	3	76	2	IPR013333
Domain	P-loop_NTPase	MYH1 MYH2 MYH4 MYH9 MYO5B ABCC8 CHD5 FIGNL2 NAV3 LRRK1 DICER1 MYO5C	1.51e-04	848	76	12	IPR027417
Domain	Myosin_S1_N	MYO5B MYO5C	1.62e-04	5	76	2	IPR008989
Domain	DIL	MYO5B MYO5C	2.43e-04	6	76	2	PF01843
Domain	RIH_assoc	RYR2 RYR3	2.43e-04	6	76	2	PF08454
Domain	RIH_assoc-dom	RYR2 RYR3	2.43e-04	6	76	2	IPR013662
Domain	RIH_dom	RYR2 RYR3	2.43e-04	6	76	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 RYR3	2.43e-04	6	76	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 RYR3	2.43e-04	6	76	2	IPR015925
Domain	Dilute_dom	MYO5B MYO5C	2.43e-04	6	76	2	IPR002710
Domain	-	RYR2 RYR3	2.43e-04	6	76	2	1.25.10.30
Domain	DILUTE	MYO5B MYO5C	2.43e-04	6	76	2	PS51126
Domain	RYDR_ITPR	RYR2 RYR3	2.43e-04	6	76	2	PF01365
Domain	DIL	MYO5B MYO5C	2.43e-04	6	76	2	SM01132
Domain	Ins145_P3_rec	RYR2 RYR3	2.43e-04	6	76	2	PF08709
Domain	ConA-like_dom	COL15A1 PTPRM TRIM36 RYR2 RYR3 TRIM7	2.68e-04	219	76	6	IPR013320
Domain	SPRY	TRIM36 RYR2 RYR3 TRIM7	5.85e-04	94	76	4	PF00622
Domain	SPRY_dom	TRIM36 RYR2 RYR3 TRIM7	5.85e-04	94	76	4	IPR003877
Domain	B30.2/SPRY	TRIM36 RYR2 RYR3 TRIM7	6.09e-04	95	76	4	IPR001870
Domain	B302_SPRY	TRIM36 RYR2 RYR3 TRIM7	6.09e-04	95	76	4	PS50188
Domain	MIR	RYR2 RYR3	7.20e-04	10	76	2	PS50919
Domain	MIR	RYR2 RYR3	7.20e-04	10	76	2	PF02815
Domain	MIR	RYR2 RYR3	7.20e-04	10	76	2	SM00472
Domain	MIR_motif	RYR2 RYR3	7.20e-04	10	76	2	IPR016093
Domain	CONNEXINS_1	GJD2 GJC2	2.67e-03	19	76	2	PS00407
Domain	CONNEXINS_2	GJD2 GJC2	2.96e-03	20	76	2	PS00408
Domain	Connexin	GJD2 GJC2	2.96e-03	20	76	2	IPR000500
Domain	Connexin_CCC	GJD2 GJC2	2.96e-03	20	76	2	IPR019570
Domain	Connexin_N	GJD2 GJC2	2.96e-03	20	76	2	IPR013092
Domain	Connexin	GJD2 GJC2	2.96e-03	20	76	2	PF00029
Domain	Connexin_CCC	GJD2 GJC2	2.96e-03	20	76	2	SM01089
Domain	Connexin_CS	GJD2 GJC2	2.96e-03	20	76	2	IPR017990
Domain	CNX	GJD2 GJC2	2.96e-03	20	76	2	SM00037
Pathway	KEGG_VIRAL_MYOCARDITIS	MYH1 MYH2 MYH4 MYH9 HLA-DOB	1.06e-05	70	59	5	M12294
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	SLC8A1 GJD2 ADRB3 GJC2 RYR2 RYR3	3.32e-05	147	59	6	MM15854
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	SLC8A1 GJD2 ADRB3 GJC2 RYR2 RYR3	3.86e-05	151	59	6	M39329
Pubmed	Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation.	MYH1 MYH2 MYH4	1.09e-08	3	78	3	26059207
Pubmed	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.	MYH1 MYH2 MYH4	4.33e-08	4	78	3	10388558
Pubmed	A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth.	MYH1 MYH2 MYH4	4.33e-08	4	78	3	11023856
Pubmed	Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle.	MYH1 MYH2 MYH4	4.33e-08	4	78	3	11029314
Pubmed	Modulation of skeletal muscle fiber type by mitogen-activated protein kinase signaling.	MYH1 MYH2 MYH4	4.33e-08	4	78	3	18417546
Pubmed	Detection of Gene and Protein Expression in Mouse Embryos and Tissue Sections.	MYH1 MYH2 MYH4	1.08e-07	5	78	3	30737693
Pubmed	Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.	MYH1 MYH2 MYH4	1.08e-07	5	78	3	6196357
Pubmed	Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.	MYH1 MYH2 MYH4	1.08e-07	5	78	3	3829126
Pubmed	Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development.	MYH1 MYH2 MYH4	1.08e-07	5	78	3	12919077
Pubmed	Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.	MYH1 MYH2 MYH4	2.16e-07	6	78	3	1728586
Pubmed	A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity.	MYH1 MYH2 MYH4	2.16e-07	6	78	3	20417199
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH1 MYH2 MYH4	2.16e-07	6	78	3	10077619
Pubmed	A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre.	MYH1 MYH2 MYH4	2.16e-07	6	78	3	17559643
Pubmed	Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.	MYH1 MYH2 MYH4	2.16e-07	6	78	3	10588881
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MYH4 MYH9 ACACA SBF1 HERC2 DICER1 MYO5C	3.74e-07	202	78	7	33005030
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH1 MYH2 MYH4	3.77e-07	7	78	3	35210422
Pubmed	ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.	MYH1 MYH2 MYH4	3.77e-07	7	78	3	29758057
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH1 MYH2 MYH4	3.77e-07	7	78	3	16819597
Pubmed	Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.	MYH1 MYH2 MYH4	6.03e-07	8	78	3	26993635
Pubmed	Cell lineage- and expression-based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development.	MYH1 MYH2 MYH4	6.03e-07	8	78	3	33667029
Pubmed	A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning.	MYH1 MYH2 MYH4	6.03e-07	8	78	3	14667415
Pubmed	Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.	CAND1 CEP76 HERC2 RPA1	7.03e-07	31	78	4	22261722
Pubmed	GASP-2 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP-1 transgenics.	MYH1 MYH2 MYH4	9.03e-07	9	78	3	31960486
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RGMA KMT2C ACACA SBF1 SLC16A5 CHD5 AOC2 WDR70 TRMT1 LRRC14 LRRK1 HERC2 TRIM7	1.02e-06	1105	78	13	35748872
Pubmed	Extracellular matrix protein composition dynamically changes during murine forelimb development.	MYH1 MYH2 MYH4	1.77e-06	11	78	3	38303699
Pubmed	Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.	MYH1 MYH2 MYH4	1.77e-06	11	78	3	18310078
Pubmed	The histone code reader Spin1 controls skeletal muscle development.	MYH1 MYH2 MYH4	1.77e-06	11	78	3	29168801
Pubmed	Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity.	MYH1 MYH2 MYH4	1.77e-06	11	78	3	8136524
Pubmed	Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.	MYH1 MYH2 MYH4	1.77e-06	11	78	3	16024798
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	SLC8A1 RYR2 RYR3	2.35e-06	12	78	3	19095005
Pubmed	Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.	MYH1 MYH2 MYH4	3.05e-06	13	78	3	8404542
Pubmed	Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy.	MYH1 MYH2 MYH4	3.88e-06	14	78	3	24938781
Pubmed	Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.	MYH1 MYH2 MYH4	3.88e-06	14	78	3	27184118
Pubmed	Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation.	MYH1 MYH2 MYH4	3.88e-06	14	78	3	33742095
Pubmed	Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.	MYH9 MYO5B MYO5C	3.88e-06	14	78	3	8022818
Pubmed	Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.	MYH1 MYH2 MYH4	4.84e-06	15	78	3	24852826
Pubmed	Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization.	HCAR3 HCAR2	4.97e-06	2	78	2	28186140
Pubmed	The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.	HCAR3 HCAR2	4.97e-06	2	78	2	30154797
Pubmed	The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.	HCAR3 HCAR2	4.97e-06	2	78	2	24371223
Pubmed	Myosin heavy chains IIa and IId are functionally distinct in the mouse.	MYH1 MYH2	4.97e-06	2	78	2	9585413
Pubmed	High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice.	HCAR3 HCAR2	4.97e-06	2	78	2	21774590
Pubmed	The role of HCA2 (GPR109A) in regulating macrophage function.	HCAR3 HCAR2	4.97e-06	2	78	2	23882124
Pubmed	Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.	HCAR3 HCAR2	4.97e-06	2	78	2	36891315
Pubmed	Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.	RYR2 RYR3	4.97e-06	2	78	2	21531043
Pubmed	GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.	HCAR3 HCAR2	4.97e-06	2	78	2	36208084
Pubmed	Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.	RYR2 RYR3	4.97e-06	2	78	2	16678258
Pubmed	Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a.	HCAR3 HCAR2	4.97e-06	2	78	2	38007572
Pubmed	The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells.	HCAR3 HCAR2	4.97e-06	2	78	2	26656756
Pubmed	Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.	HCAR3 HCAR2	4.97e-06	2	78	2	37597514
Pubmed	The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.	HCAR3 HCAR2	4.97e-06	2	78	2	33924461
Pubmed	Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.	HCAR3 HCAR2	4.97e-06	2	78	2	24691444
Pubmed	Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx.	HCAR3 HCAR2	4.97e-06	2	78	2	33977048
Pubmed	Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.	HCAR3 HCAR2	4.97e-06	2	78	2	31347703
Pubmed	PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily.	HCAR3 HCAR2	4.97e-06	2	78	2	11745392
Pubmed	Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis.	HCAR3 HCAR2	4.97e-06	2	78	2	30659164
Pubmed	Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.	HCAR3 HCAR2	4.97e-06	2	78	2	25622782
Pubmed	Analysis of mouse conceptuses with uniparental duplication/deficiency for distal chromosome 12: comparison with chromosome 12 uniparental disomy and implications for genomic imprinting.	MYH1 MYH2	4.97e-06	2	78	2	16575183
Pubmed	GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice.	HCAR3 HCAR2	4.97e-06	2	78	2	33420329
Pubmed	Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium.	HCAR3 HCAR2	4.97e-06	2	78	2	19223991
Pubmed	Molecular identification of nicotinic acid receptor.	HCAR3 HCAR2	4.97e-06	2	78	2	12646212
Pubmed	PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.	HCAR3 HCAR2	4.97e-06	2	78	2	12563315
Pubmed	Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.	HCAR3 HCAR2	4.97e-06	2	78	2	23967184
Pubmed	Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice.	HCAR3 HCAR2	4.97e-06	2	78	2	26371038
Pubmed	Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle.	MYH1 MYH2	4.97e-06	2	78	2	7545970
Pubmed	Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease.	HCAR3 HCAR2	4.97e-06	2	78	2	34653248
Pubmed	Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G).	HCAR3 HCAR2	4.97e-06	2	78	2	19136666
Pubmed	G Protein-Coupled Receptor 109A Maintains the Intestinal Integrity and Protects Against ETEC Mucosal Infection by Promoting IgA Secretion.	HCAR3 HCAR2	4.97e-06	2	78	2	33488584
Pubmed	Lactate-induced activation of HCA2 improves survival in mice with sepsis.	HCAR3 HCAR2	4.97e-06	2	78	2	30951370
Pubmed	Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.	SLC8A1 RYR2	4.97e-06	2	78	2	22456474
Pubmed	Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.	RYR2 RYR3	4.97e-06	2	78	2	8898078
Pubmed	Growth and muscle defects in mice lacking adult myosin heavy chain genes.	MYH1 MYH4	4.97e-06	2	78	2	9382868
Pubmed	Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains.	MYH1 MYH4	4.97e-06	2	78	2	11150240
Pubmed	Myosin heavy chain composition of the human genioglossus muscle.	MYH1 MYH2	4.97e-06	2	78	2	22337492
Pubmed	Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet.	HCAR3 HCAR2	4.97e-06	2	78	2	31858105
Pubmed	Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.	HCAR3 HCAR2	4.97e-06	2	78	2	30625381
Pubmed	Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy.	HCAR3 HCAR2	4.97e-06	2	78	2	32068460
Pubmed	The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.	HCAR3 HCAR2	4.97e-06	2	78	2	30657794
Pubmed	Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.	HCAR3 HCAR2	4.97e-06	2	78	2	30085883
Pubmed	Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.	HCAR3 HCAR2	4.97e-06	2	78	2	21655214
Pubmed	Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.	HCAR3 HCAR2	4.97e-06	2	78	2	34092246
Pubmed	(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.	HCAR3 HCAR2	4.97e-06	2	78	2	15929991
Pubmed	The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.	RYR2 RYR3	4.97e-06	2	78	2	14550562
Pubmed	Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.	HCAR3 HCAR2	4.97e-06	2	78	2	36991440
Pubmed	Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages.	HCAR3 HCAR2	4.97e-06	2	78	2	25320346
Pubmed	Molecular identification of high and low affinity receptors for nicotinic acid.	HCAR3 HCAR2	4.97e-06	2	78	2	12522134
Pubmed	Nicotinic acid inhibits glucose-stimulated insulin secretion via the G protein-coupled receptor PUMA-G in murine islet β cells.	HCAR3 HCAR2	4.97e-06	2	78	2	21441844
Pubmed	G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.	HCAR3 HCAR2	4.97e-06	2	78	2	30271409
Pubmed	Niacin fine-tunes energy homeostasis through canonical GPR109A signaling.	HCAR3 HCAR2	4.97e-06	2	78	2	30596513
Pubmed	The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.	HCAR3 HCAR2	4.97e-06	2	78	2	35320002
Pubmed	GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.	HCAR3 HCAR2	4.97e-06	2	78	2	16322797
Pubmed	BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease.	HCAR3 HCAR2	4.97e-06	2	78	2	31914599
Pubmed	Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling.	MYH2 MYH4	4.97e-06	2	78	2	21102503
Pubmed	Nicotinic acid receptor agonists.	HCAR3 HCAR2	4.97e-06	2	78	2	18983141
Pubmed	Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms.	HCAR3 HCAR2	4.97e-06	2	78	2	31366236
Pubmed	Myosin-IIA and ICAM-1 regulate the interchange between two distinct modes of T cell migration.	MYH2 MYH9	4.97e-06	2	78	2	19201857
Pubmed	Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.	HCAR3 HCAR2	4.97e-06	2	78	2	20655299
Pubmed	Evidence for constitutive dimerization of niacin receptor subtypes.	HCAR3 HCAR2	4.97e-06	2	78	2	20380810
Pubmed	GPR109A Expression in the Murine Min6 Pancreatic Beta Cell Line, and Its Relation with Glucose Metabolism and Inflammation.	HCAR3 HCAR2	4.97e-06	2	78	2	26116596
Pubmed	Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function.	HCAR3 HCAR2	4.97e-06	2	78	2	35649469
Pubmed	GPR109A expressed on medullary thymic epithelial cells affects thymic Treg development.	HCAR3 HCAR2	4.97e-06	2	78	2	37595951
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	MYH1 MYH2 MYH4 SENP3 CAMTA2 SPNS3 RPA1	2.17e-06	346	78	7	chr17p13
GeneFamily	Myosin heavy chains	MYH1 MYH2 MYH4 MYH9	1.10e-07	15	56	4	1098
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR2 RYR3	2.82e-05	3	56	2	287
GeneFamily	Hydroxy-carboxylic acid receptors	HCAR3 HCAR2	2.82e-05	3	56	2	200
GeneFamily	Myosins, class V	MYO5B MYO5C	2.82e-05	3	56	2	1100
GeneFamily	Gap junction proteins	GJD2 GJC2	2.09e-03	22	56	2	314
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELP BCAN	7.15e-03	41	56	2	1298
GeneFamily	C1-set domain containing	CD1B HLA-DOB	7.49e-03	42	56	2	591
Coexpression	GSE16386_IL4_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_6H_DN	IFNB1 HCAR2 GJD2 NALCN ABCC8 OTOG	2.62e-05	198	77	6	M7916
Coexpression	HUMMERICH_BENIGN_SKIN_TUMOR_DN	MYH1 MYH2 MYH4	2.68e-05	20	77	3	M1123
Coexpression	HALLMARK_MYOGENESIS	MYH1 MYH2 MYH4 MYH9 COL15A1 CDH13	2.77e-05	200	77	6	M5909
Coexpression	HUMMERICH_BENIGN_SKIN_TUMOR_DN	MYH1 MYH2 MYH4	3.12e-05	21	77	3	MM1102
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH1 SLC8A1 SCN2A NAV3 RYR2 RYR3 OTOG	3.53e-08	184	78	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH1 SLC8A1 SCN2A NAV3 RYR2 RYR3 OTOG	3.53e-08	184	78	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH1 SLC8A1 SCN2A NAV3 RYR2 RYR3 OTOG	3.53e-08	184	78	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD1B SLC8A1 ADRB3 HLA-DOB LTC4S LRRK1 MCOLN2	5.07e-08	194	78	7	e56c6e5c9b7d287ae94566b561e21cec2055f83d
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD1B SLC8A1 ADRB3 HLA-DOB LTC4S LRRK1 MCOLN2	5.25e-08	195	78	7	85fee07d71c0393ea42bcf1130566dff4a62f507
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-cDC1\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC8A1 NALCN HLA-DOB AOC2 LRRK1 MCOLN2	5.28e-07	169	78	6	da3485d77bb7876fad4f166f6099e681b27457ae
ToppCell	NS-moderate-d_07-13-Lymphoid-NK\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RGMA COL15A1 NAV3 BCAN RAB3IL1 CDH13	6.47e-07	175	78	6	f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCell	tumor_Lung-Myeloid_cells-CD207+CD1a+_LCs\|tumor_Lung / Location, Cell class and cell subclass	CD1B SLC8A1 ADRB3 HLA-DOB OCSTAMP MCOLN2	8.14e-07	182	78	6	243779ba1009097f8fafa1a691e296ec3aeefc04
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD1B SLC8A1 ADRB3 HLA-DOB LTC4S LRRK1	8.67e-07	184	78	6	1c56378b3888c46258d446b47de4d6282fe74b0d
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD1B SLC8A1 ADRB3 HLA-DOB LTC4S LRRK1	8.67e-07	184	78	6	a45980306c4e697a2703bed72a7b48fb23d942f4
ToppCell	COVID-19-Myeloid-DC2\|COVID-19 / Condition, Lineage and Cell class	CD1B SLC8A1 ADRB3 HLA-DOB LTC4S LRRK1	1.08e-06	191	78	6	1304ab7b5713f29f3966ffc020ea1b52e8e2f375
ToppCell	cellseq-Immune-Immune_Myeloid-Myeloid_Dendritic\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD1B SLC8A1 ADRB3 HLA-DOB SPNS3 MCOLN2	1.18e-06	194	78	6	74d588de2f84a4ef112fd642f7e112a542d5ef11
ToppCell	Transplant_Alveoli_and_parenchyma-Immune-Dendritic_cells\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	CD1B SLC8A1 ADRB3 HLA-DOB LTC4S MCOLN2	1.25e-06	196	78	6	f278b144b8deaee0bf41682081b9fbb0b1e82b19
ToppCell	Control-Myeloid-DC2\|Myeloid / Condition, Lineage and Cell class	CD1B ADRB3 HLA-DOB LTC4S SPNS3 MCOLN2	1.29e-06	197	78	6	e0ee15188ff0d9df3c3b5ea523553ce18d223c33
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD1B SLC8A1 ADRB3 HLA-DOB LTC4S MCOLN2	1.33e-06	198	78	6	59214e34b077dffa989c48635fdef143f57f1320
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Dendritic_cell\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CD1B SLC8A1 ADRB3 HLA-DOB LRRK1 MCOLN2	1.41e-06	200	78	6	1adebb306112bfc4926678de80f70d35dd57a586
ToppCell	Influenza-Influenza_Severe-Myeloid-cDC\|Influenza_Severe / Disease, condition lineage and cell class	CD1B GPR135 SPNS3 RYR3 MYO5C MCOLN2	1.41e-06	200	78	6	b8415a68ad6f4fea562236a1b0da0dc376d874fb
ToppCell	RV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	SLC8A1 NPIPB7 PTPRM CDH13 RYR2	2.43e-06	122	78	5	1cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Sphkap\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MYH2 ADGRG3 MTNR1A SPNS3	2.87e-06	56	78	4	af55596513ddbe60b08648b27e41a7b65e3da58c
ToppCell	Adult-Immune-dendritic_cell-D122\|Adult / Lineage, Cell type, age group and donor	C5orf34 SLC8A1 HLA-DOB LRRK1 MCOLN2	7.60e-06	154	78	5	64a4686586d08b1e9632dde917b472ac660de2d3
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_D3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SELP HCAR3 ADGRG3 SLC16A5 LTC4S	9.43e-06	161	78	5	3e5a125a25d55bf27652f456239b00b315d54d91
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	COL15A1 CHD5 CDH13 RYR2 RYR3	1.33e-05	173	78	5	a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TPTE COL15A1 MTNR1A CDH13 RYR2	1.37e-05	174	78	5	9f2e253694eb5860c00528fda31c305c6de8a2a1
ToppCell	P15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADGRG3 GJC2 LTC4S RAB3IL1 RYR3	1.41e-05	175	78	5	84d252f3e432231687613299bbea14978bb4b06b
ToppCell	P15-Endothelial-lymphatic_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADGRG3 GJC2 LTC4S RAB3IL1 RYR3	1.41e-05	175	78	5	a00c6fa9b33640710dd05a3799031147196f0986
ToppCell	Dendritic_Cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	CD1B ADRB3 HLA-DOB LRRK1 MCOLN2	1.49e-05	177	78	5	d2cd081bdda0eba9f6f6473c4d3939e4bee3440e
ToppCell	metastatic_Brain-Myeloid_cells-CD207+CD1a+_LCs\|metastatic_Brain / Location, Cell class and cell subclass	CD1B SLC8A1 ADRB3 HLA-DOB OCSTAMP	1.62e-05	180	78	5	51727cb66fe7a7709453f7026e0ff3d6c93d5aa5
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	RGMA SLC8A1 ADRB3 MTNR1A BCAN	1.66e-05	181	78	5	7e3bcfa2ba5b98a7df5854aa6e7a31e9a71faa8a
ToppCell	IPF-Myeloid-DC_Langerhans\|World / Disease state, Lineage and Cell class	CD1B SLC8A1 HLA-DOB LRRK1 MCOLN2	1.70e-05	182	78	5	0e8cfbd8ea196f27a227dbb4d2eb93bc48d27922
ToppCell	P03-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADGRG3 GJC2 LTC4S RAB3IL1 CDH13	1.75e-05	183	78	5	89727b4f65949ed2dce9d2e0228c79fe4280230c
ToppCell	cellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-maDC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD1B ADRB3 HLA-DOB LRRK1 MCOLN2	1.75e-05	183	78	5	e01dacb08a9c36cf09c0b6764ce032a7232d4cdc
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 MYO5B TRIM36 RYR3 EPG5	1.75e-05	183	78	5	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	P03-Endothelial-lymphatic_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADGRG3 GJC2 LTC4S RAB3IL1 CDH13	1.75e-05	183	78	5	113e6d8d4bb271be984af06cd6c22b180425dcfc
ToppCell	IPF-Myeloid-DC_Langerhans\|IPF / Disease state, Lineage and Cell class	CD1B SLC8A1 HLA-DOB LRRK1 MCOLN2	1.84e-05	185	78	5	f8ee3cb2aa9ec70f9ce8797be2b155da27ef6464
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1B SLC8A1 ADRB3 HLA-DOB OCSTAMP	1.84e-05	185	78	5	7cf69717b88347833819c161ca89e751416f6c67
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KMT2C SLC8A1 SCN2A ZFHX3 RYR2	1.89e-05	186	78	5	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYH1 MYH9 COL15A1 PTPRM MYO5C	1.94e-05	187	78	5	0ef82111b9049cc7ee78d64d240e1f10ab14d6b6
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_granulocytic\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HCAR3 HCAR2 SLC8A1 ADGRG3 LTC4S	1.99e-05	188	78	5	36ff615154d6d9e3ba6ccb73a0f11574bcbf5ece
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC8 CHD5 ZFHX3 CDH13 RYR2	2.04e-05	189	78	5	7fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-cDC2-C\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HCAR3 HCAR2 ADRB3 SPNS3 MCOLN2	2.04e-05	189	78	5	cfa45fa6b13fcd3f54c29c823885f5b938812474
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC8 CHD5 ZFHX3 CDH13 RYR2	2.04e-05	189	78	5	06b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCell	(3)_DC_activated\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	CD1B ADRB3 HLA-DOB LRRK1 MCOLN2	2.04e-05	189	78	5	e977838793fc0eb1499e81018e33e4ccb4a5f0c5
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG3 PCDHGB5 SCN2A NAV3 GJC2	2.10e-05	190	78	5	e80d66ba0d5c263e94c1ab0b89d1dc7b837af3e1
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1B ADRB3 HLA-DOB LRRK1 MCOLN2	2.10e-05	190	78	5	2ff4b50b864a35f22c558d7d585cd2b54612b50c
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG3 PCDHGB5 SCN2A NAV3 GJC2	2.10e-05	190	78	5	f32d66c0e74e0a2a23ecb857c4daf0d8573a806c
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG3 PCDHGB5 SCN2A NAV3 GJC2	2.10e-05	190	78	5	b79ffd05806244a9790cd04c66fb4f92c824e69f
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A1 NALCN ABCC8 NAV3 RYR2	2.10e-05	190	78	5	562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	SLC8A1 CHD5 SCN2A ZFHX3 RYR2	2.10e-05	190	78	5	6e92c78799f34b31d098854503c796edb0dc7f80
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A1 NALCN ABCC8 NAV3 RYR2	2.10e-05	190	78	5	f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-Migratory_DCs_L.1.2.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1B ADRB3 HLA-DOB LRRK1 MCOLN2	2.10e-05	190	78	5	5175bf022d55a52988014abe7cece326a8406a38
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1B ADRB3 HLA-DOB LRRK1 MCOLN2	2.10e-05	190	78	5	29e60b9b1c86b44550619c01306b8b1bb2e340dc
ToppCell	368C-Myeloid-Dendritic-cDC2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CD1B SLC8A1 ADRB3 HLA-DOB LTC4S	2.15e-05	191	78	5	85dba3a8a52307df52d1d78a6f278501298f3067
ToppCell	droplet-Lung-30m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RGMA BMP7 ADGRG3 NAV3 GJC2	2.15e-05	191	78	5	51cff0594ac7ad8c065c8ea2301f8c149bd062b4
ToppCell	COPD-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	CD1B SLC8A1 HLA-DOB LTC4S MCOLN2	2.15e-05	191	78	5	4e4887175200a57e1b041f2f131e3df774df3509
ToppCell	droplet-Lung-30m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RGMA BMP7 ADGRG3 NAV3 GJC2	2.15e-05	191	78	5	a55b6f0a7ec1a8852ffca593cfdccd7edea09b7b
ToppCell	droplet-Lung-30m-Endothelial-lymphatic_endothelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RGMA BMP7 ADGRG3 NAV3 GJC2	2.15e-05	191	78	5	38681a1b182d6af5cce85db5431b6eba4b20ad96
ToppCell	367C-Myeloid-Dendritic-cDC2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CD1B ADRB3 HLA-DOB SPNS3 MCOLN2	2.26e-05	193	78	5	940e9a419d0de1f9e72b5cc9c86684057003be58
ToppCell	MNPs-Dendritic_Cells\|MNPs / lung cells shred on cell class, cell subclass, sample id	CD1B HLA-DOB LTC4S SPNS3 MCOLN2	2.26e-05	193	78	5	0e6b8e179bfe1c6e93137c76c76a91c7782a4989
ToppCell	10x5'-Lung-Myeloid_Dendritic\|Lung / Manually curated celltypes from each tissue	CD1B SLC8A1 HLA-DOB LRRK1 MCOLN2	2.26e-05	193	78	5	7bce609699c515d2d114596a0c527f90cc09c4af
ToppCell	COVID-19-Myeloid-DC2\|Myeloid / Condition, Lineage and Cell class	CD1B SLC8A1 ADRB3 HLA-DOB LTC4S	2.26e-05	193	78	5	5f3f6db3d3de887d004662d229f42549601efa81
ToppCell	10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-basophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HCAR3 MYH9 ADGRG3 LTC4S RYR3	2.32e-05	194	78	5	5da8873cddff582e5693b32fd3aaebc102f65fc0
ToppCell	cellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD1B SLC8A1 ADRB3 HLA-DOB MCOLN2	2.32e-05	194	78	5	024568d8a862f0fe4da1f66a58c6e71f0e8279f3
ToppCell	distal-2-Hematologic-Myeloid_Dendritic_Type_2\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD1B ADRB3 HLA-DOB SPNS3 MCOLN2	2.32e-05	194	78	5	6881cfe12837a32e598535a564e4c31d4846167b
ToppCell	medial-2-Hematologic-Myeloid_Dendritic_Type_2\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD1B ADRB3 HLA-DOB SPNS3 MCOLN2	2.37e-05	195	78	5	54a404ee1b97d0659fcffafb20d11f878ed453d4
ToppCell	distal-Hematologic-Myeloid_Dendritic_Type_2-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD1B ADRB3 HLA-DOB SPNS3 MCOLN2	2.37e-05	195	78	5	7606b8b40e704bb5447ac57ccf8698794e9c7890
ToppCell	medial-Hematologic-Myeloid_Dendritic_Type_2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD1B ADRB3 HLA-DOB SPNS3 MCOLN2	2.37e-05	195	78	5	c0d1ecb378bb482a8e08d7065fcca07a65687dac
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD1B SLC8A1 LTC4S LRRK1 MCOLN2	2.37e-05	195	78	5	7bb3bdfb8caaae357b1f7841d8d00936c4373dfe
ToppCell	Healthy_Control-Myeloid-mDC\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	CD1B ADRB3 HLA-DOB LTC4S MCOLN2	2.37e-05	195	78	5	32f505b2c24f4386367706b775e79271f99156f2
ToppCell	medial-Hematologic-Myeloid_Dendritic_Type_2-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD1B ADRB3 HLA-DOB SPNS3 MCOLN2	2.37e-05	195	78	5	35a5302b8b3e76bc92dc38979400c979f0e86550
ToppCell	Transplant_Alveoli_and_parenchyma-Immune-Dendritic_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	CD1B ADRB3 HLA-DOB LTC4S MCOLN2	2.37e-05	195	78	5	c12c73861f53e28f6e357001eccc1300db06e816
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD1B SLC8A1 LTC4S LRRK1 MCOLN2	2.37e-05	195	78	5	d579150d176e6bd81004b5146de4901ca13a3c3e
ToppCell	Control-Myeloid-MoAM4\|Control / Condition, Lineage and Cell class	CD1B ADRB3 HLA-DOB LTC4S LRRK1	2.37e-05	195	78	5	211a736acbe875bd3c1942c62aaacc9b170ece6d
ToppCell	Healthy_Control-Myeloid-mDC-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	CD1B ADRB3 HLA-DOB LTC4S MCOLN2	2.37e-05	195	78	5	d9a6fc7fa0047472821e1dcf0962ccb3f061313e
ToppCell	Control-Myeloid-DC2\|Control / Condition, Lineage and Cell class	CD1B ADRB3 HLA-DOB LTC4S MCOLN2	2.43e-05	196	78	5	0ccc26c2811e4c8631e0abd8555b167ac1e7a982
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Neuronal-CPNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	SLC8A1 CHD5 SCN2A CDH13 RYR2	2.43e-05	196	78	5	c9e7ac34993c873de4f198cdae77dcf099731532
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 PTPRM NAV3 CDH13 RYR3	2.49e-05	197	78	5	cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1B ADRB3 HLA-DOB LRRK1 MCOLN2	2.49e-05	197	78	5	2a140c61e81aa18de2c9c1c443e314d6f09cdc18
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1B ADRB3 HLA-DOB LRRK1 MCOLN2	2.49e-05	197	78	5	fa3fe934bd5fd8c6520a9c46357f9e441c794aba
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Dendritic_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CD1B SLC8A1 ADRB3 LRRK1 MCOLN2	2.49e-05	197	78	5	e0fc098bfb5a8b7824ae339f3adda30f78360d0b
ToppCell	BAL-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CD1B ADRB3 HLA-DOB LTC4S MCOLN2	2.49e-05	197	78	5	513ada82bbbb6a624d89edaa54f8c4a303dfb5e7
ToppCell	BAL-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD1B ADRB3 HLA-DOB LTC4S MCOLN2	2.49e-05	197	78	5	6f83fc049f38f3de6bc5180ad4b51ceb4d5dcdb6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SELP COL15A1 PTPRM NAV3 RYR3	2.49e-05	197	78	5	412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell	Control-Myeloid-cDC\|Control / Disease group,lineage and cell class （2021.01.30）	CD1B ADRB3 HLA-DOB LTC4S MCOLN2	2.49e-05	197	78	5	aef933107da42a763b35041c90950db07707c0cb
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Dendritic_cell\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CD1B SLC8A1 ADRB3 HLA-DOB MCOLN2	2.49e-05	197	78	5	7e15ed71881105dee5c7ffc052063ecc8ac0b36e
ToppCell	BAL-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CD1B ADRB3 HLA-DOB LTC4S MCOLN2	2.49e-05	197	78	5	15e683f4a610aad3e06723747c8e56ca25f57414
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-Migratory_DCs_L.1.2.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD1B ADRB3 HLA-DOB LRRK1 MCOLN2	2.49e-05	197	78	5	32eb4437cc608b8369e376446d639497ecfdd17a
ToppCell	BAL-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD1B ADRB3 HLA-DOB LTC4S MCOLN2	2.49e-05	197	78	5	6ac50c02899531a25885749d5305da788dfa9dbc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SELP PTPRM NAV3 CDH13 RYR3	2.55e-05	198	78	5	07701c73137947ed4a27e225975329235bbb8734
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD1B SLC8A1 ADRB3 LTC4S MCOLN2	2.55e-05	198	78	5	7f7024b26337ae2bc7f57c3274a7dfdaaa64ab7c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SELP PTPRM NAV3 CDH13 RYR3	2.55e-05	198	78	5	fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCell	distal-3-Hematologic-Myeloid_Dendritic_Type_1\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD1B ADRB3 HLA-DOB LRRK1 MCOLN2	2.55e-05	198	78	5	b21227c7366ef79b36048509a91d2d35fd5e4956
ToppCell	BAL-Severe-Myeloid-cDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADRB3 HLA-DOB LTC4S LRRK1 MCOLN2	2.61e-05	199	78	5	0b20ae65b9340d844e271acda9e116d98fc1cc69
ToppCell	distal-Hematologic-Myeloid_Dendritic_Type_1-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD1B ADRB3 HLA-DOB LRRK1 MCOLN2	2.61e-05	199	78	5	3860f30114b54abff91898308df71b8b4e05b51e
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	HCAR3 HCAR2 MYH9 ADGRG3 MMP8	2.61e-05	199	78	5	5919933c4b842b98fc98685dc8c72c8dd32c6ea3
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CD1B SLC8A1 ADRB3 HLA-DOB MCOLN2	2.61e-05	199	78	5	fdd8c4c04837341e17a4772a2adcdf2f187c56b1
ToppCell	BAL-Severe-Myeloid-cDC-cDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADRB3 HLA-DOB LTC4S LRRK1 MCOLN2	2.61e-05	199	78	5	bb9e7418468b88cdfaa78788d062362794ea8230
ToppCell	distal-2-Hematologic-Myeloid_Dendritic_Type_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD1B ADRB3 HLA-DOB SPNS3 MCOLN2	2.61e-05	199	78	5	86ee039189c75e66b97453c20a34d7fb5a31e51d
ToppCell	BAL-Severe-Myeloid-cDC-cDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADRB3 HLA-DOB LTC4S LRRK1 MCOLN2	2.61e-05	199	78	5	9a0e853693e572c63b135f937b2cffd4dd4026fb
ToppCell	Severe_COVID-19-Myeloid-cDC\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	ADRB3 HLA-DOB LTC4S LRRK1 MCOLN2	2.61e-05	199	78	5	9132c1929d3445fcca49f76f010ca37adeb70315
ToppCell	BAL-Severe-Myeloid-cDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADRB3 HLA-DOB LTC4S LRRK1 MCOLN2	2.61e-05	199	78	5	d017848256704ae7237030868b143c3f0842a9c3
Drug	formycin triphosphate	MYH1 MYH2 MYH4 MYH9 MYO5B MYO5C	2.12e-08	51	78	6	CID000122274
Drug	clenbuterol	MYH1 MYH2 MYH4 MYH9 ADRB3 MYO5B AOC2 MYO5C	3.05e-08	142	78	8	CID000002783
Drug	purealin	MYH1 MYH2 MYH4 MYH9 MYO5B MYO5C	4.67e-08	58	78	6	CID006419303
Drug	S-(-)-Etomoxir	MYH1 MYH2 MYH4 MYH9 ACACA MYO5B MYO5C	5.22e-08	100	78	7	CID000060765
Drug	blebbistatin	RGMA MYH1 MYH2 MYH4 MYH9 MYO5B MYO5C	1.45e-07	116	78	7	CID003476986
Drug	AC1N9ZZC	MYH1 MYH2 MYH4 ADRB3 NAV3 RYR2 RYR3	7.99e-07	149	78	7	CID004369374
Drug	carvedilol	MYH1 MYH2 MYH4 MYH9 ADRB3 MYO5B MMP8	1.34e-06	161	78	7	CID000002585
Drug	trifluoperazine	MYH1 HCAR3 MYH2 MYH4 HCAR2 MYH9 ACACA MYO5B MYO5C	1.65e-06	324	78	9	CID000005566
Drug	B0683	MYH1 MYH2 MYH4 MYH9 MYO5B MYO5C	3.07e-06	117	78	6	CID006398969
Drug	LOPAC	ADRB3 SCN2A RYR2 RYR3	3.26e-06	30	78	4	CID000062696
Drug	carbachol	MYH1 HCAR3 MYH2 MYH4 HCAR2 MYH9 ADRB3 MYO5B MMP8 RYR2 RYR3 MYO5C	3.69e-06	688	78	12	CID000002551
Drug	creatine	MYH1 MYH2 MYH4 MYO5B GJC2 RYR2 RYR3	4.48e-06	193	78	7	CID000000586
Drug	AC1LADJ6	IFNB1 MYH1 MYH2 MYH4 MYH9 MYO5B	5.66e-06	130	78	6	CID000486032
Drug	verapamil	SELP MYH1 HCAR3 MYH2 MYH4 HCAR2 MYH9 MYO5B RYR2 RYR3	6.61e-06	490	78	10	CID000002520
Drug	AC1L1IZ2	MYH1 MYH2 MYH4 MYH9 MYO5B RYR2 RYR3 MYO5C	9.61e-06	304	78	8	CID000004795
Drug	NSC107658	MYH1 MYH2 MYH4 MYH9 MYO5B AOC2 MMP8 MYO5C	1.01e-05	306	78	8	CID000002919
Drug	fast white	MYH1 MYH2 MYH4 MYO5B	1.29e-05	42	78	4	CID000024008
Drug	2-hydroxycarbazole	RYR2 RYR3	3.47e-05	3	78	2	CID000093551
Drug	cis-diammineplatinum(II	RYR2 RYR3	3.47e-05	3	78	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR2 RYR3	3.47e-05	3	78	2	CID002750949
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR2 RYR3	3.47e-05	3	78	2	CID005748312
Drug	8N3-cADPR	RYR2 RYR3	3.47e-05	3	78	2	CID000127713
Drug	aminodantrolene	RYR2 RYR3	3.47e-05	3	78	2	CID009570289
Drug	eye gene	MYH1 MYH2 MYH4 MYH9 ADRB3 ACACA MYO5B MYO5C	3.85e-05	369	78	8	CID000004782
Drug	PCB74	RYR2 RYR3	6.92e-05	4	78	2	CID000036218
Drug	148504-47-6	RYR2 RYR3	6.92e-05	4	78	2	CID006444275
Drug	SC 38249	RYR2 RYR3	6.92e-05	4	78	2	CID000134834
Drug	AC1L1U7A	RYR2 RYR3	6.92e-05	4	78	2	CID000035682
Drug	Niacin	HCAR3 HCAR2	6.92e-05	4	78	2	DB00627
Drug	succinylcholine	HCAR3 HCAR2 RYR2 RYR3	6.93e-05	64	78	4	CID000005314
Drug	procyclidine	HCAR3 HCAR2 CDH13	7.43e-05	24	78	3	CID000004919
Drug	D-triiodothyronine	MYH1 MYH2 MYH4 MYH9 ADRB3 ACACA MYO5B LTC4S	7.92e-05	409	78	8	CID000000861
Drug	nifedipine	MYH1 MYH2 MYH4 MYH9 ADRB3 MYO5B RYR2 RYR3	8.77e-05	415	78	8	CID000004485
Drug	strontium	MYH4 RYR2 RYR3 MYO5C	8.79e-05	68	78	4	CID000104798
Drug	isoproterenol	MYH1 MYH2 MYH4 MYH9 ADRB3 MYO5B ABCC8 RYR2 RYR3 MYO5C	9.33e-05	669	78	10	CID000003779
Drug	acifran	HCAR3 HCAR2	1.15e-04	5	78	2	ctd:C036804
Drug	K-Cl	MYH1 MYH2 MYH4 MYH9 ADRB3 MYO5B RYR2 RYR3 MYO5C	1.37e-04	567	78	9	CID000004873
Drug	candesartan cilexetil	MYH1 MYH2 MYH4 MYH9 MYO5B	1.42e-04	145	78	5	CID000002540
Drug	nicardipine	HCAR3 HCAR2 BDKRB1 RYR2 RYR3	1.42e-04	145	78	5	CID000004473
Drug	MBED	RYR2 RYR3	1.72e-04	6	78	2	CID000129958
Drug	chloro-m-cresol	RYR2 RYR3	1.72e-04	6	78	2	CID000012008
Drug	AC1O528X	RYR2 RYR3	1.72e-04	6	78	2	CID006475857
Drug	NSC114784	RYR2 RYR3	1.72e-04	6	78	2	CID000419425
Drug	sulfoxamine	ABCC8 MMP8	1.72e-04	6	78	2	CID003000415
Drug	chrysene	MYH1 MYH4 SLC8A1 HLA-DOB UQCRQ LTC4S TUG1 LRRK1 MMP8 DICER1 CDH13	1.80e-04	871	78	11	ctd:C031180
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH2 MYH4	1.87e-06	10	75	3	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH2 MYH4	1.87e-06	10	75	3	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH2 MYH4	1.87e-06	10	75	3	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH2 MYH4	1.87e-06	10	75	3	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH2 MYH4	1.87e-06	10	75	3	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH2 MYH4	1.87e-06	10	75	3	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH2 MYH4	1.87e-06	10	75	3	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH2 MYH4	1.87e-06	10	75	3	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH2 MYH4	3.41e-06	12	75	3	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH2 MYH4	3.41e-06	12	75	3	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH2 MYH4	4.43e-06	13	75	3	DOID:397 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 COL15A1	6.88e-06	48	75	4	DOID:423 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH2 MYH4	7.02e-06	15	75	3	DOID:0050646 (implicated_via_orthology)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR2 RYR3	1.91e-05	3	75	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR2 RYR3	1.91e-05	3	75	2	DOID:8545 (implicated_via_orthology)
Disease	cardiomyopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 COL15A1	3.29e-05	71	75	4	DOID:0050700 (implicated_via_orthology)
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 DICER1	5.26e-05	80	75	4	DOID:12930 (implicated_via_orthology)
Disease	AIDS dementia	SLC8A1 NALCN	9.50e-05	6	75	2	EFO_0002608
Disease	congestive heart failure (biomarker_via_orthology)	SELP SLC8A1 ADRB3 MMP8	1.63e-04	107	75	4	DOID:6000 (biomarker_via_orthology)
Disease	hypertension (is_implicated_in)	SLC8A1 ADRB3 ABCC8 BDKRB1	2.61e-04	121	75	4	DOID:10763 (is_implicated_in)
Disease	generalised epilepsy	MMP8 TRIM36 RYR2	3.19e-04	52	75	3	EFO_0005917
Disease	polybrominated biphenyl measurement, gestational serum measurement, fetal genotype effect measurement, polybrominated diphenyl ether measurement	PTPRM ZFHX3	3.45e-04	11	75	2	EFO_0007959, EFO_0007961, EFO_0007962, EFO_0007964
Disease	adiponectin measurement	RGMA HCAR2 HERC2 CDH13	5.32e-04	146	75	4	EFO_0004502
Disease	eating disorder, bipolar disorder	NALCN RYR2	5.69e-04	14	75	2	EFO_0005203, MONDO_0004985
Disease	glucose homeostasis measurement, glucose effectiveness measurement	CDH13 MYO5C	6.55e-04	15	75	2	EFO_0006833, EFO_0006896
Disease	esophageal carcinoma, gastric carcinoma	BDKRB1 EPG5	8.46e-04	17	75	2	EFO_0000178, EFO_0002916
Disease	mucocutaneous lymph node syndrome	HLA-DOB ZFHX3 EPG5	9.70e-04	76	75	3	EFO_0004246
Disease	susceptibility to scarlet fever measurement	HLA-DOB SPNS3 CDH13	1.09e-03	79	75	3	EFO_0008409
Disease	anti-Mullerian hormone measurement	RGMA MYH4	1.18e-03	20	75	2	EFO_0004769
Disease	breast cancer (is_marker_for)	BMP7 ZFHX3 MMP8 CDH13	1.28e-03	185	75	4	DOID:1612 (is_marker_for)
Disease	Abnormality of refraction	RGMA BMP7 SLC8A1 GJD2 MYO5B SCN2A ZFHX3	1.61e-03	673	75	7	HP_0000539
Disease	trans fatty acid measurement, trans/trans-18:2 fatty acid measurement	CDH13 RYR3	1.70e-03	24	75	2	EFO_0006821, EFO_0006826
Disease	middle cerebral artery infarction (biomarker_via_orthology)	RGMA BCAN DICER1	1.74e-03	93	75	3	DOID:3525 (biomarker_via_orthology)
Disease	sciatic neuropathy (biomarker_via_orthology)	RGMA MYH4 ABCC8	2.08e-03	99	75	3	DOID:11446 (biomarker_via_orthology)
Disease	obsessive-compulsive disorder	HCAR3 HCAR2 GPR135	2.14e-03	100	75	3	EFO_0004242
Disease	periodontitis	RGMA SCN2A ZFHX3 CDH13	2.54e-03	223	75	4	EFO_0000649

Protein segments in the cluster

Peptide	Gene	Start	Entry
VGLETFNRARYRQFV	EPG5	626	Q9HCE0
FLVVAISQDRYRVLV	BDKRB1	126	P46663
RQEGISRFYIIQVVF	GJD2	191	Q9UKL4
SRFYIIQVVFRNALE	GJD2	196	Q9UKL4
YRFVTRASVEERITQ	CHD5	1146	Q8TDI0
QRFVELVVVVDNIRY	ADAM20	206	O43506
RELYEAARVIQTAFR	CAMTA2	1046	O94983
VTDYRFFVRAIIRHS	ACACA	1416	Q13085
TIILYAFLRLSRERF	ADGRG3	286	Q86Y34
GDQVRLAVRVRVFTY	CEP76	626	Q8TAP6
LFVYARVFVVATRQL	ADRB3	221	P13945
RTLDREVIAVYQLFV	CDH13	201	P55290
VRATRLAFEYQRQFR	DHTKD1	406	Q96HY7
IFVERRYTAVVLNRL	DICER1	446	Q9UPY3
EIFRVYIFGFAREVQ	CD1B	86	P29016
IRERFDNETFRISVY	BMP7	181	P18075
RYYAFDLIAQRVTRV	MMP8	441	P22894
RARITAVCNFFTYIR	RAB3IL1	331	Q8TBN0
RIRESFFRVVPQFVV	UQCRQ	41	O14949
LRIFDVRFQGERIAY	AOC2	341	O75106
VRVKVNEAYRFRVAL	BCAN	96	Q96GW7
VFRRVYVQRDEVRQI	KMT2C	4521	Q8NEZ4
FRVERIATLRAYVLA	LRRK1	766	Q38SD2
RVYVAQLVARAAFEV	GJC2	211	Q5T442
IFLTVVAVDRYFRVV	HCAR2	116	Q8TDS4
ILERYFIALNRTVFQ	HERC2	146	O95714
LREYCIQAFESFVRR	CAND1	271	Q86VP6
AQYIRTERVEQAFRA	PCMTD1	21	Q96MG8
YFSLQVISARRAFRV	LTC4S	21	Q16873
RAIVFTRQLVTYIVV	OR52A4P	136	A6NMU1
VERREAIFCIQYNIR	MYH2	811	Q9UKX2
VIRRLFKEYVFRIDT	NAV3	1956	Q8IVL0
FVFRIRVAYQREPQI	NOL6	791	Q9H6R4
RRESIFCIQYNVRAF	MYH1	811	P12882
RVVFQEFRQRYEILT	MYH9	711	P35579
IIIIIGFLRRYTFNV	NPIPB7	61	O75200
VFNRDVYRVSLRENV	PCDHGB5	241	Q9Y5G0
ARRLEVVRNCISYVF	SBF1	561	O95248
NFRSFIFRVRVKVET	RPA1	566	P27694
VRPVNTYARVLRFFS	GPR135	311	Q8IZ08
QFVVRFIFNLEEYVR	HLA-DOB	51	P13765
IVRVEILRNFYFINR	IFNB1	166	P01574
IAILYQRFQRVVFGI	SELP	6	P16109
LDEATRRRFSLRFYV	FIGNL2	541	A6NMB9
ERIRQRTHFVISTYR	C5orf34	51	Q96MH7
FIYLRDSTEFFIRVR	COL15A1	1156	P39059
ARVIRSTVFLFNRFI	RYR2	416	Q92736
FRLEFYRLLQVEISF	MCOLN2	211	Q8IZK6
EDIISRIFRIYNAAR	PTPRM	1321	P28827
FLRVRTNVGVRVLYD	OTOG	616	Q6ZRI0
ISADFYVRVFVRVFT	TRMT1	316	Q9NXH9
YVRVFVRVFTGQAKV	TRMT1	321	Q9NXH9
FTLETIVERYRQAAR	TRIM36	136	Q9NQ86
IFLTVVAVDRYFRVV	HCAR3	116	P49019
RLTLAAIYRFITERF	FOXE3	91	Q13461
RRESIFCIQYNIRAF	MYH4	811	Q9Y623
FTIDVTYFPRRDVVR	OCSTAMP	541	Q9BR26
VVRLARVRDHYIFSV	POLR1C	296	O15160
IVVRQVGRYLTFAVR	RGMA	281	Q96B86
EVNVIRVRRYIFFKT	ABCC8	186	Q09428
RRAVVVFVRHFLCYI	PRXL2C	56	Q7RTV5
VDVRRRTITYFDSQR	SENP3	471	Q9H4L4
VLLRVFVERRQQYFS	TPTE	141	P56180
FRLIQFYEVVESSLR	SPATA2	61	Q9UM82
RHLYTFRVNFQERVF	TRIM7	481	Q9C029
ITVLGFYFVRRRVLA	SLC16A5	126	O15375
VRDQRTRVLAVFYIF	SPNS3	166	Q6ZMD2
VSIDKIRFFRVERSY	RYR3	1066	Q15413
FERRTFQRVYEIDIT	WDR70	456	Q9NW82
EVSAIIIQRAYRRYL	SCN2A	1906	Q99250
VFLLVRRTRAAAYAF	TUG1	56	A0A6I8PU40
AAYAFAIRRGVVRVV	TUG1	66	A0A6I8PU40
IRFFNRFIDIRAYVT	WASHC4	716	Q2M389
CEVFRQRFRQFQYRE	ZNF449	26	Q6P9G9
RTRFTDYQLRVLQDF	ZFHX3	2246	Q15911
YRRIIVSLCTARVFF	MTNR1A	306	P48039
EVRVDLRVNRASYAF	LRRC14	166	Q15048
IFAFINVGVLLYRRR	SLC8A1	916	P32418
IYFRFELPRTRITNI	NALCN	156	Q8IZF0
AYQRVRRAAVVIQAF	MYO5B	831	Q9ULV0
FLRERRAALIIQQYF	MYO5C	776	Q9NQX4