Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A7	1.84e-05	3	50	2	GO:0008389
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2A6 CYP2A7	1.64e-03	24	50	2	GO:0008392
GeneOntologyMolecularFunction	gap junction channel activity	GJA4 GJA8	1.78e-03	25	50	2	GO:0005243
GeneOntologyMolecularFunction	aminoacyltransferase activity	AREL1 FBXO44 FBXO17 HERC2 TRIM52 EPB42	2.04e-03	532	50	6	GO:0016755
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2A6 CYP2A7	2.07e-03	27	50	2	GO:0008391
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	AREL1 FBXO44 FBXO17 HERC2 TRIM52	2.33e-03	372	50	5	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	AREL1 FBXO44 FBXO17 HERC2 TRIM52	3.11e-03	398	50	5	GO:0061659
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP2A6 CYP2A7	3.28e-03	34	50	2	GO:0008395
GeneOntologyMolecularFunction	aromatase activity	CYP2A6 CYP2A7	3.47e-03	35	50	2	GO:0070330
GeneOntologyMolecularFunction	wide pore channel activity	GJA4 GJA8	3.87e-03	37	50	2	GO:0022829
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A7	4.20e-05	4	50	2	IPR008067
Domain	F-box-assoc_dom	FBXO44 FBXO17	1.05e-04	6	50	2	IPR007397
Domain	FBA	FBXO44 FBXO17	1.05e-04	6	50	2	PS51114
Domain	FBA	FBXO44 FBXO17	1.05e-04	6	50	2	PF04300
Domain	FBA	FBXO44 FBXO17	1.05e-04	6	50	2	SM01198
Domain	KRAB	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF77	3.71e-04	358	50	6	PS50805
Domain	KRAB	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF77	3.71e-04	358	50	6	PF01352
Domain	KRAB	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF77	4.36e-04	369	50	6	SM00349
Domain	KRAB	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF77	4.42e-04	370	50	6	IPR001909
Domain	SEA	MUC3B MUC3A	6.26e-04	14	50	2	SM00200
Domain	-	FBXO44 FBXO17 HERC2	9.84e-04	73	50	3	2.60.120.260
Domain	CONNEXINS_1	GJA4 GJA8	1.17e-03	19	50	2	PS00407
Domain	CONNEXINS_2	GJA4 GJA8	1.29e-03	20	50	2	PS00408
Domain	Connexin	GJA4 GJA8	1.29e-03	20	50	2	IPR000500
Domain	Connexin_CCC	GJA4 GJA8	1.29e-03	20	50	2	IPR019570
Domain	Connexin_N	GJA4 GJA8	1.29e-03	20	50	2	IPR013092
Domain	Connexin	GJA4 GJA8	1.29e-03	20	50	2	PF00029
Domain	Connexin_CCC	GJA4 GJA8	1.29e-03	20	50	2	SM01089
Domain	Connexin_CS	GJA4 GJA8	1.29e-03	20	50	2	IPR017990
Domain	CNX	GJA4 GJA8	1.29e-03	20	50	2	SM00037
Domain	zf-C2H2_6	ZNF135 ZNF473 ZNF468 ZNF710 ZNF77	1.48e-03	314	50	5	PF13912
Domain	FCH	FCHSD2 FCHO2	1.57e-03	22	50	2	PF00611
Domain	FCH	FCHSD2 FCHO2	1.57e-03	22	50	2	SM00055
Domain	SEA	MUC3B MUC3A	1.71e-03	23	50	2	PS50024
Domain	SEA_dom	MUC3B MUC3A	1.71e-03	23	50	2	IPR000082
Domain	FCH_dom	FCHSD2 FCHO2	1.71e-03	23	50	2	IPR001060
Domain	F_BAR	FCHSD2 FCHO2	2.03e-03	25	50	2	IPR031160
Domain	F_BAR	FCHSD2 FCHO2	2.03e-03	25	50	2	PS51741
Domain	Galactose-bd-like	FBXO44 FBXO17 HERC2	2.04e-03	94	50	3	IPR008979
Domain	-	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF710 ZNF77	2.09e-03	679	50	7	3.30.160.60
Domain	zf-C2H2	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF710 ZNF77	2.34e-03	693	50	7	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF710 ZNF77	2.36e-03	694	50	7	IPR013087
Domain	HECT	AREL1 HERC2	2.36e-03	27	50	2	PF00632
Domain	HECTc	AREL1 HERC2	2.36e-03	27	50	2	SM00119
Domain	HECT_dom	AREL1 HERC2	2.36e-03	27	50	2	IPR000569
Domain	HECT	AREL1 HERC2	2.36e-03	27	50	2	PS50237
Domain	Ank_2	NFKB2 PPP1R13B POTEI ASB15	2.60e-03	215	50	4	PF12796
Domain	Ig_E-set	AREL1 NFKB2 EPB42	2.72e-03	104	50	3	IPR014756
Domain	Ank	NFKB2 PPP1R13B POTEI ASB15	3.21e-03	228	50	4	PF00023
Domain	EGF	MEP1A MUC3B FCGBP MUC3A	3.58e-03	235	50	4	SM00181
Domain	-	NFKB2 PPP1R13B POTEI ASB15	4.33e-03	248	50	4	1.25.40.20
Domain	ZINC_FINGER_C2H2_2	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF710 ZNF77	4.35e-03	775	50	7	PS50157
Domain	EGF-like_dom	MEP1A MUC3B FCGBP MUC3A	4.39e-03	249	50	4	IPR000742
Domain	ZINC_FINGER_C2H2_1	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF710 ZNF77	4.41e-03	777	50	7	PS00028
Domain	ANK	NFKB2 PPP1R13B POTEI ASB15	4.52e-03	251	50	4	SM00248
Domain	ANK_REPEAT	NFKB2 PPP1R13B POTEI ASB15	4.65e-03	253	50	4	PS50088
Domain	Ankyrin_rpt-contain_dom	NFKB2 PPP1R13B POTEI ASB15	4.71e-03	254	50	4	IPR020683
Domain	ANK_REP_REGION	NFKB2 PPP1R13B POTEI ASB15	4.71e-03	254	50	4	PS50297
Domain	Znf_C2H2-like	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF710 ZNF77	5.03e-03	796	50	7	IPR015880
Domain	Ankyrin_rpt	NFKB2 PPP1R13B POTEI ASB15	5.26e-03	262	50	4	IPR002110
Domain	Znf_C2H2	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF710 ZNF77	5.34e-03	805	50	7	IPR007087
Domain	ZnF_C2H2	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF710 ZNF77	5.45e-03	808	50	7	SM00355
Domain	F-box-like	FBXO44 FBXO17	6.18e-03	44	50	2	PF12937
Domain	Cyt_P450_E_grp-I	CYP2A6 CYP2A7	6.46e-03	45	50	2	IPR002401
Pubmed	Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.	CYP2A6 CYP2A7	2.19e-06	2	52	2	12325023
Pubmed	Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus.	MUC3B MUC3A	2.19e-06	2	52	2	12958310
Pubmed	CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.	CYP2A6 CYP2A7	2.19e-06	2	52	2	16636685
Pubmed	The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.	CYP2A6 CYP2A7	2.19e-06	2	52	2	2322567
Pubmed	Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B.	MUC3B MUC3A	2.19e-06	2	52	2	10973822
Pubmed	Expression and alternative splicing of the cytochrome P-450 CYP2A7.	CYP2A6 CYP2A7	2.19e-06	2	52	2	7864805
Pubmed	MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region.	MUC3B MUC3A	2.19e-06	2	52	2	9334251
Pubmed	Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6).	CYP2A6 CHRNA5	2.19e-06	2	52	2	24033696
Pubmed	Molecular cloning of cDNAs derived from a novel human intestinal mucin gene.	MUC3B MUC3A	2.19e-06	2	52	2	2393399
Pubmed	Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease.	MUC3B MUC3A	2.19e-06	2	52	2	11289722
Pubmed	OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3.	OTUD1 IRF3	2.19e-06	2	52	2	32075857
Pubmed	[Association between genotype and allele frequencies of CYP2A6*12 and rs16969968 in CHRNA5 variants with smoking and body mass index in young subjects from Northeast Mexico].	CYP2A6 CHRNA5	2.19e-06	2	52	2	26757861
Pubmed	The MUC3 gene encodes a transmembrane mucin and is alternatively spliced.	MUC3B MUC3A	2.19e-06	2	52	2	10405327
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A7	6.57e-06	3	52	2	31645370
Pubmed	CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	CYP2A6 CYP2A7	6.57e-06	3	52	2	11960914
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A7	6.57e-06	3	52	2	3346244
Pubmed	Combined analysis of CHRNA5, CHRNA3 and CYP2A6 in relation to adolescent smoking behaviour.	CYP2A6 CHRNA5	6.57e-06	3	52	2	21765098
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A7	6.57e-06	3	52	2	2733794
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A7	6.57e-06	3	52	2	8297477
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A7	6.57e-06	3	52	2	8188299
Pubmed	Expression of mucin 3 and mucin 5AC in arthritic synovial tissue.	MUC3B MUC3A	6.57e-06	3	52	2	18163520
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A7	6.57e-06	3	52	2	8484736
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A7	6.57e-06	3	52	2	8250953
Pubmed	Age-related accumulation of Reelin in amyloid-like deposits.	PSEN1 SYNGAP1	6.57e-06	3	52	2	17904250
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A7	6.57e-06	3	52	2	2703500
Pubmed	Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin.	MUC3B MUC3A	6.57e-06	3	52	2	10512748
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A7	6.57e-06	3	52	2	1417950
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A7	6.57e-06	3	52	2	24045421
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A7	6.57e-06	3	52	2	32987105
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A7	6.57e-06	3	52	2	22217847
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A7	6.57e-06	3	52	2	2765478
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A7	6.57e-06	3	52	2	2415518
Pubmed	SNPs within CHRNA5-A3-B4 and CYP2A6/B6, nicotine metabolite concentrations and nicotine dependence treatment success in smokers.	CYP2A6 CHRNA5	6.57e-06	3	52	2	31796940
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A7	6.57e-06	3	52	2	22890016
Pubmed	CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.	CYP2A6 CYP2A7	6.57e-06	3	52	2	25710939
Pubmed	Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk.	CYP2A6 CHRNA5	1.31e-05	4	52	2	21747048
Pubmed	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.	CYP2A6 CYP2A7	1.31e-05	4	52	2	9408084
Pubmed	Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.	CYP2A6 CYP2A7	1.31e-05	4	52	2	10490589
Pubmed	Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide.	CYP2A6 CHRNA5	1.31e-05	4	52	2	25072098
Pubmed	Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.	CYP2A6 CYP2A7	1.31e-05	4	52	2	1970547
Pubmed	A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation.	IRF3 FBXO17	1.31e-05	4	52	2	27956528
Pubmed	A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.	CYP2A6 CYP2A7	1.31e-05	4	52	2	7565685
Pubmed	Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders.	OTUD1 IRF3	1.31e-05	4	52	2	30100102
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	KDM3A THNSL1 FBXO44 OTUD1 YLPM1 KLHL8 FBXO17 HERC2 GPRASP2	1.63e-05	1005	52	9	19615732
Pubmed	A new subfamily of structurally related human F-box proteins.	FBXO44 FBXO17	2.19e-05	5	52	2	12383498
Pubmed	Chromosomal localization of four human zinc finger cDNAs.	ZNF135 ZNF77	2.19e-05	5	52	2	8478004
Pubmed	A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling.	NFKB2 IRF3	2.19e-05	5	52	2	30018345
Pubmed	Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes.	GJA8 CFTR	2.19e-05	5	52	2	17546509
Pubmed	The DNA sequence and analysis of human chromosome 14.	AREL1 PSEN1 YLPM1 PPP1R13B	2.36e-05	111	52	4	12508121
Pubmed	A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.	CYP2A6 CYP2A7	3.28e-05	6	52	2	7668294
Pubmed	Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.	CYP2A6 CYP2A7	3.28e-05	6	52	2	8587134
Pubmed	Genetic diseases and gene knockouts reveal diverse connexin functions.	GJA4 GJA8	4.58e-05	7	52	2	10099690
Pubmed	Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.	CYP2A6 CYP2A7	4.58e-05	7	52	2	14630516
Pubmed	Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy.	NFKB2 IRF3	4.58e-05	7	52	2	30170810
Pubmed	Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.	CYP2A6 CYP2A7	4.58e-05	7	52	2	9630227
Pubmed	I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection.	NFKB2 IRF3	6.10e-05	8	52	2	23422957
Pubmed	Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases.	FBXO44 FBXO17	6.10e-05	8	52	2	18203720
Pubmed	Diverse functions of vertebrate gap junctions.	GJA4 GJA8	6.10e-05	8	52	2	9861669
Pubmed	Skp1 stabilizes the conformation of F-box proteins.	FBXO44 FBXO17	6.10e-05	8	52	2	21640084
Pubmed	A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins.	GJA4 GJA8	7.84e-05	9	52	2	32272685
Pubmed	Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.	CYP2A6 CYP2A7	7.84e-05	9	52	2	37838304
Pubmed	A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.	CYP2A6 CHRNA5	9.79e-05	10	52	2	22080838
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	KDM3A ZNF473 YLPM1 ZNF565 HERC2 ZNF583 GPRASP2 TRIM52 SYNGAP1	1.10e-04	1285	52	9	35914814
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	FCHSD2 PSEN1 ZNF473 INPP1 HOMER3 CWF19L1 GPRASP2	1.14e-04	742	52	7	26871637
Pubmed	Multiple members of the connexin gene family participate in preimplantation development of the mouse.	GJA4 GJA8	1.20e-04	11	52	2	8631157
Pubmed	mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse.	GJA4 GJA8	1.20e-04	11	52	2	15255617
Pubmed	Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.	CYP2A6 CHRNA5	1.43e-04	12	52	2	25006744
Pubmed	Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.	PSEN1 YLPM1	1.43e-04	12	52	2	7596406
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP2A6 CYP2A7	2.27e-04	15	52	2	29968852
Pubmed	Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.	CYP2A6 CYP2A7	2.94e-04	17	52	2	27197076
Pubmed	An expression atlas of connexin genes in the mouse.	GJA4 GJA8	3.30e-04	18	52	2	15081111
Pubmed	The novel mouse connexin39 gene is expressed in developing striated muscle fibers.	GJA4 GJA8	3.30e-04	18	52	2	15466892
Pubmed	An update on connexin genes and their nomenclature in mouse and man.	GJA4 GJA8	3.69e-04	19	52	2	14681012
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP2A6 CYP2A7	4.09e-04	20	52	2	9890157
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KDM3A FCHSD2 PPP1R13B	4.74e-04	101	52	3	9872452
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	AREL1 HERC2	6.96e-04	26	52	2	26949039
Pubmed	Resveratrol improves health and survival of mice on a high-calorie diet.	CYP2A6 CYP2A7	6.96e-04	26	52	2	17086191
Pubmed	FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.	YLPM1 FCHO2	9.92e-04	31	52	2	22323290
Pubmed	Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis.	GJA4 PSEN1	1.49e-03	38	52	2	22783020
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	CYP2A6 CYP2A7 ZNF135 FCGBP ZNF473 IRF3 ZNF565 FBXO17 ZNF468 ZNF583	7.88e-07	1192	52	10	chr19q13
Cytoband	14q24.3	AREL1 PSEN1 YLPM1	1.65e-04	93	52	3	14q24.3
Cytoband	7q22	MUC3B MUC3A	8.62e-04	38	52	2	7q22
Cytoband	19q13.2	CYP2A6 CYP2A7 FBXO17	8.70e-04	164	52	3	19q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr14q24	AREL1 PSEN1 YLPM1	1.54e-03	200	52	3	chr14q24
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF135 ZNF473 ZNF565 ZNF468 ZNF583 ZNF710 ZNF77	6.51e-04	718	38	7	28
GeneFamily	CD molecules\|Mucins	MUC3B MUC3A	8.81e-04	21	38	2	648
GeneFamily	Gap junction proteins	GJA4 GJA8	9.68e-04	22	38	2	314
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	FCHSD2 FCHO2	1.06e-03	23	38	2	1288
GeneFamily	Ankyrin repeat domain containing	NFKB2 PPP1R13B POTEI ASB15	1.62e-03	242	38	4	403
GeneFamily	Cytochrome P450 family 2	CYP2A6 CYP2A7	2.45e-03	35	38	2	1001
GeneFamily	Cyclins\|F-boxes other	FBXO44 FBXO17	3.03e-03	39	38	2	560
Drug	ASA404	CYP2A6 ECD NFKB2 IRF3	6.52e-06	53	52	4	CID000123964
Drug	chlorzoxazone	CYP2A6 CYP2A7 CFTR ZNF77	1.30e-05	63	52	4	CID000002733
Drug	2'-methoxyacetophenone	CYP2A6 CYP2A7	1.53e-05	3	52	2	CID000068481
Disease	nicotine metabolite ratio	CYP2A6 CYP2A7	1.62e-04	12	47	2	EFO_0007794
Disease	TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)	CYP2A6 CHRNA5	1.62e-04	12	47	2	C1861063
Disease	Tobacco Dependence	CYP2A6 CHRNA5	2.23e-04	14	47	2	C0040332
Disease	Nicotine Dependence	CYP2A6 CHRNA5	2.23e-04	14	47	2	C0028043
Disease	Nicotine Use Disorder	CYP2A6 CHRNA5	2.23e-04	14	47	2	C0376384
Disease	emphysema pattern measurement	CYP2A6 CHRNA5	4.17e-04	19	47	2	EFO_0005850
Disease	caffeine metabolite measurement	CYP2A6 CYP2A7	4.17e-04	19	47	2	EFO_0007872
Disease	Bronchiectasis	NFKB2 CFTR	5.62e-04	22	47	2	C0006267
Disease	cotinine measurement	CYP2A6 CHRNA5	6.15e-04	23	47	2	EFO_0007813
Disease	smoking cessation	CYP2A6 CYP2A7 TBC1D22A CHRNA5	1.77e-03	325	47	4	EFO_0004319
Disease	heart rate response to exercise	MUC3B MUC3A	2.15e-03	43	47	2	EFO_0009184

Protein segments in the cluster

Peptide	Gene	Start	Entry
AESWDFGQFEGDVID	EPB42	176	P16452
NVTAFWEEGFGELFE	CFTR	396	P13569
FVTEQNWDSLEVFDG	CSMD2	1841	Q7Z408
EEFSGRGEQATFDWV	CYP2A6	96	P11509
FVENFWGEKNSGFDV	FCHO2	6	Q0JRZ9
GDIFGNSFVWSEIQE	ASB15	451	Q8WXK1
VGEEDCAEFSGNGWN	CD209	351	Q9NNX6
FGVTKFGDNIEDEWF	ECD	76	O95905
LDFGVNVNAADSDGW	PPP1R13B	941	Q96KQ4
FFTSGNEGNWFEIQT	DSG3	306	P32926
DVGEFIIAAAQDGAW	OTUD1	361	Q5VV17
IFGEESNEFTNDWGE	INPP1	76	P49441
EDGEVYTWGDNDEGQ	HERC2	4266	O95714
FNAGLSWGQDQDEED	LBHD1	146	Q9BQE6
SEGSVGEVQWEAEFF	HOMER3	176	Q9NSC5
GEVQWEAEFFALQDS	HOMER3	181	Q9NSC5
VGNFFGSTQDAEWEE	CWF19L1	41	Q69YN2
GDGEDSFIFEANEAW	KLHL8	36	Q9P2G9
EEVVGTFSNWGFEDD	MUC3A	3276	Q02505
CAEEGFEFWSLDVNG	FBXO44	86	Q9H4M3
GTQFGQWDTAGFENE	KNOP1	356	Q1ED39
FNSCGEQGFRGWEVE	FBXO17	111	Q96EF6
DFFDNGEWEIVSATG	CHRNA5	211	P30532
TGATVGDFWDGFEDV	KDM3A	1016	Q9Y4C1
AGNANEFGNSWEEVV	FCGBP	3811	Q9Y6R7
EEFSGRGEQATFDWV	CYP2A7	96	P20853
AEFVWGDEQSDFVCN	GJA8	41	P48165
TVNDDENAFGTLWGV	C4orf17	51	Q53FE4
FEVVFQDEEALDWGG	AREL1	491	O15033
GESVWGDEQSDFECN	GJA4	41	P35212
NQDDDGFWEGEFNGR	FCHSD2	601	O94868
AQQEDFGIFQAWAEA	IRF3	46	Q14653
EVVGTFSNWGFEDDG	MUC3B	1191	Q9H195
DTVAENDDGGFSEEW	PSEN1	326	P49768
NDDGGFSEEWEAQRD	PSEN1	331	P49768
DEASNPFSFWVGENT	GPRASP2	286	Q96D09
IFQQFDGCWSEVGDQ	MEP1A	121	Q16819
NVGAWGDYDDSAFVE	POTEI	116	P0CG38
GENNTAKGDFFWDDG	SI	821	P14410
FGDFDWVIENHGVEQ	PMVK	161	Q15126
FTQGDSWGEGEVDEE	ARL6IP6	31	Q8N6S5
FQDQDDDELWLGDSG	TRIM52	96	Q96A61
SIFGENWRFDNTGDQ	ZNF77	81	Q15935
EGSDFRADWECEGQF	ZNF565	151	Q8N9K5
FEDVVVGFSQEEWGQ	ZNF135	16	P52742
ASGDTVFWGEHFEFN	SYNGAP1	301	Q96PV0
FVWQEASEFEADTAG	ZNF710	246	Q8N1W2
ENGWAVGVESDFDFC	THNSL1	426	Q8IYQ7
FQEFESNTSDAWDAG	TBC1D22A	61	Q8WUA7
EDSFYGLWDTNDEQG	YLPM1	1576	P49750
GFEFQWKEDETNGHA	ZNF468	96	Q5VIY5
VTFGDVAVNFSQEEW	ZNF583	6	Q96ND8
GFWNSNFGEACIEDT	ZNF473	106	Q8WTR7
DENGWQAFGDFSPTD	NFKB2	266	Q00653