Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane transporter activity

NIPAL4 ABCA3 CACNA2D2 ABCA12 SLC38A4 SLC35F1 SLC7A7 SLC7A6 SLC40A1 SLC22A7 SLC6A1 SLC6A8 SLC6A11 SLC7A4 CLCN1 SLC22A13 SCN4A SLC10A6 NIPAL2 SLC17A7 CACNA1I ATP12A SLC25A28 ATP4A

4.27e-08118011424GO:0022857
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC38A4 SLC6A1 SLC6A8 SLC6A11 SCN4A SLC10A6 SLC17A7 CACNA1I ATP12A ATP4A

5.15e-0817111410GO:0015081
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

NIPAL4 CACNA2D2 SLC38A4 SLC40A1 SLC6A1 SLC6A8 SLC6A11 SCN4A SLC10A6 NIPAL2 SLC17A7 CACNA1I ATP12A SLC25A28 ATP4A

6.49e-0846511415GO:0046873
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC38A4 SLC7A7 SLC7A6 SLC6A1 SLC6A8 SLC6A11 SLC7A4 SLC17A7

1.55e-071051148GO:0015171
GeneOntologyMolecularFunctiontransporter activity

NIPAL4 ABCA3 CACNA2D2 ABCA12 SLC38A4 SLC35F1 SLC7A7 SLC7A6 SLC40A1 SLC22A7 SLC6A1 SLC6A8 SLC6A11 SLC7A4 CLCN1 SLC22A13 SCN4A SLC10A6 NIPAL2 SLC17A7 CACNA1I ATP12A SLC25A28 ATP4A

2.21e-07128911424GO:0005215
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC38A4 SLC7A7 SLC7A6 SLC22A7 SLC6A1 SLC6A8 SLC6A11 SLC22A13 SLC10A6 SLC17A7

3.08e-0720711410GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC38A4 SLC7A7 SLC7A6 SLC22A7 SLC6A1 SLC6A8 SLC6A11 SLC22A13 SLC10A6 SLC17A7

3.22e-0720811410GO:0005342
GeneOntologyMolecularFunctionmonocarboxylate:sodium symporter activity

SLC6A1 SLC6A8 SLC6A11 SLC10A6

1.31e-06151144GO:0140161
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC38A4 SLC6A1 SLC6A8 SLC6A11 SLC10A6

1.57e-06351145GO:0005343
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

NIPAL4 CACNA2D2 SLC38A4 SLC40A1 SLC6A1 SLC6A8 SLC6A11 SCN4A SLC10A6 NIPAL2 SLC17A7 CACNA1I ATP12A SLC25A28 ATP4A

2.84e-0662711415GO:0022890
GeneOntologyMolecularFunctiongamma-aminobutyric acid:sodium:chloride symporter activity

SLC6A1 SLC6A8 SLC6A11

3.58e-0661143GO:0005332
GeneOntologyMolecularFunctionsecondary active monocarboxylate transmembrane transporter activity

SLC6A1 SLC6A8 SLC6A11 SLC10A6

3.66e-06191144GO:0015355
GeneOntologyMolecularFunctionbasic amino acid transmembrane transporter activity

SLC38A4 SLC7A7 SLC7A6 SLC7A4

4.55e-06201144GO:0015174
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

NIPAL4 CACNA2D2 SLC38A4 SLC40A1 SLC6A1 SLC6A8 SLC6A11 SCN4A SLC10A6 NIPAL2 SLC17A7 CACNA1I ATP12A SLC25A28 ATP4A

5.68e-0666411415GO:0008324
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

NIPAL4 CACNA2D2 SLC38A4 SLC40A1 SLC6A1 SLC6A8 SLC6A11 CLCN1 SCN4A SLC10A6 NIPAL2 SLC17A7 CACNA1I ATP12A SLC25A28 ATP4A

6.37e-0675811416GO:0015318
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC38A4 SLC6A1 SLC6A8 SLC6A11 SLC10A6 SLC17A7

6.95e-06811146GO:0015370
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC38A4 SLC7A7 SLC7A6 SLC22A7 SLC6A1 SLC6A8 SLC6A11 SLC22A13 SLC10A6 SLC17A7

7.05e-0629311410GO:0008514
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC38A4 SLC6A1 SLC6A8 SLC6A11

8.21e-06231144GO:0005283
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

NIPAL4 CACNA2D2 SLC38A4 SLC40A1 SLC6A1 SLC6A8 SLC6A11 CLCN1 SCN4A SLC10A6 NIPAL2 SLC17A7 CACNA1I ATP12A SLC25A28 ATP4A

1.12e-0579311416GO:0015075
GeneOntologyMolecularFunctiongamma-aminobutyric acid transmembrane transporter activity

SLC6A1 SLC6A8 SLC6A11

1.48e-0591143GO:0015185
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ABCA3 ABCA12 SLC38A4 SLC7A6 SLC22A7 SLC6A1 SLC6A8 SLC6A11 SLC10A6 SLC17A7 ATP12A ATP4A

1.83e-0547711412GO:0022804
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC38A4 SLC6A1 SLC6A8 SLC6A11

2.14e-05291144GO:0005416
GeneOntologyMolecularFunctionL-arginine transmembrane transporter activity

SLC38A4 SLC7A7 SLC7A6

4.97e-05131143GO:0061459
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC38A4 SLC6A1 SLC6A8 SLC6A11 SLC10A6 SLC17A7

6.23e-051191146GO:0015294
GeneOntologyMolecularFunctionP-type potassium:proton transporter activity

ATP12A ATP4A

9.66e-0531142GO:0008900
GeneOntologyMolecularFunctionsodium:chloride symporter activity

SLC6A1 SLC6A8 SLC6A11

1.16e-04171143GO:0015378
GeneOntologyMolecularFunctionmonoatomic anion:sodium symporter activity

SLC6A1 SLC6A8 SLC6A11

1.64e-04191143GO:0015373
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

SLC6A1 SLC6A8 SLC6A11 SLC22A13 SLC10A6

1.66e-04901145GO:0008028
GeneOntologyMolecularFunctionsymporter activity

SLC38A4 SLC6A1 SLC6A8 SLC6A11 SLC10A6 SLC17A7

2.23e-041501146GO:0015293
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC6A1 SLC6A8 SLC6A11

2.95e-04231143GO:0015377
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC38A4 SLC7A6 SLC22A7 SLC6A1 SLC6A8 SLC6A11 SLC10A6 SLC17A7

3.00e-042961148GO:0015291
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC38A4 SLC6A1 SLC6A8 SLC6A11 SLC10A6 SLC17A7 ATP12A ATP4A

3.36e-043011148GO:0022853
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC6A1 SLC6A8 SLC6A11

4.28e-04261143GO:0015296
GeneOntologyMolecularFunctionbeta-N-acetylhexosaminidase activity

HEXA HEXD

4.77e-0461142GO:0004563
GeneOntologyMolecularFunctioncollagen receptor activity

DDR2 ITGA2

4.77e-0461142GO:0038064
GeneOntologyMolecularFunctionferrous iron transmembrane transporter activity

SLC40A1 SLC25A28

4.77e-0461142GO:0015093
GeneOntologyMolecularFunctionADP phosphatase activity

ENTPD1 ENTPD2

6.66e-0471142GO:0043262
GeneOntologyMolecularFunctionL-amino acid transmembrane transporter activity

SLC38A4 SLC7A7 SLC7A6 SLC17A7

7.29e-04711144GO:0015179
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC6A1 SLC6A8 SLC6A11 CLCN1 SLC17A7

7.56e-041251145GO:0015108
GeneOntologyMolecularFunctioncell adhesion mediator activity

ITGA2 CNTN6 IZUMO1 PKP2

9.42e-04761144GO:0098631
GeneOntologyMolecularFunctionUDP phosphatase activity

ENTPD1 ENTPD2

1.13e-0391142GO:0045134
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC38A4 SLC7A7 SLC7A6 SLC6A8

1.31e-03831144GO:0015101
GeneOntologyMolecularFunctionP-type sodium transporter activity

ATP12A ATP4A

1.41e-03101142GO:0008554
GeneOntologyMolecularFunctionP-type proton-exporting transporter activity

ATP12A ATP4A

1.41e-03101142GO:0008553
GeneOntologyMolecularFunctionP-type sodium:potassium-exchanging transporter activity

ATP12A ATP4A

1.41e-03101142GO:0005391
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

HEXA GALC HEXD MUTYH MGAM2

1.42e-031441145GO:0016798
GeneOntologyMolecularFunctionP-type potassium transmembrane transporter activity

ATP12A ATP4A

1.72e-03111142GO:0008556
GeneOntologyMolecularFunctioniron ion transmembrane transporter activity

SLC40A1 SLC25A28

1.72e-03111142GO:0005381
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC6A1 SLC6A8 SLC6A11 CLCN1 SLC17A7

1.75e-031511145GO:0008509
GeneOntologyMolecularFunctionGDP phosphatase activity

ENTPD1 ENTPD2

2.05e-03121142GO:0004382
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing O-glycosyl compounds

HEXA GALC HEXD MGAM2

2.89e-031031144GO:0004553
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC6A1 SLC6A8 SLC6A11 CLCN1 SLC17A7

3.01e-031711145GO:0015103
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCA3 ABCA12 ATP12A ATP4A

3.54e-031091144GO:0042626
GeneOntologyMolecularFunctionhexosaminidase activity

HEXA HEXD

4.15e-03171142GO:0015929
GeneOntologyMolecularFunctionprotein binding involved in heterotypic cell-cell adhesion

IZUMO1 PKP2

4.66e-03181142GO:0086080
GeneOntologyMolecularFunctionmagnesium ion transmembrane transporter activity

NIPAL4 NIPAL2

4.66e-03181142GO:0015095
GeneOntologyMolecularFunctioncell-cell adhesion mediator activity

CNTN6 IZUMO1 PKP2

5.13e-03611143GO:0098632
GeneOntologyMolecularFunctionendopeptidase activator activity

LGMN PSENEN

5.19e-03191142GO:0061133
GeneOntologyMolecularFunctionnucleoside diphosphate phosphatase activity

ENTPD1 ENTPD2

5.74e-03201142GO:0017110
GeneOntologyBiologicalProcesssodium ion transport

DRD2 SLC38A4 SLC6A1 SLC6A8 SLC6A11 SCN4A SLC10A6 PKP2 SLC17A7 CACNA1I ATP12A ATP4A

7.29e-0827512012GO:0006814
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC38A4 SLC6A1 SLC6A8 SLC6A11 SCN4A SLC17A7 CACNA1I ATP12A ATP4A

3.61e-062081209GO:0035725
GeneOntologyBiologicalProcessmonoatomic ion transport

NIPAL4 HIF1A DRD2 CACNA2D2 SLC38A4 SLC40A1 SLC22A7 SLC6A1 SLC6A8 SLC6A11 PLLP CLCN1 SCN4A SLC10A6 NIPAL2 PKP2 SLC17A7 CACNA1I MMP9 ATP12A SLC25A28 ATP4A CYBA

3.76e-06137412023GO:0006811
GeneOntologyBiologicalProcessbasic amino acid transmembrane transport

SLC38A4 SLC7A7 SLC7A6 SLC7A4

3.95e-06191204GO:1990822
GeneOntologyBiologicalProcessmetal ion transport

NIPAL4 HIF1A DRD2 CACNA2D2 SLC38A4 SLC40A1 SLC6A1 SLC6A8 SLC6A11 SCN4A SLC10A6 NIPAL2 PKP2 SLC17A7 CACNA1I ATP12A SLC25A28 ATP4A CYBA

5.02e-06100012019GO:0030001
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

NIPAL4 HIF1A DRD2 CACNA2D2 SLC38A4 SLC40A1 SLC6A1 SLC6A8 SLC6A11 PLLP CLCN1 SCN4A NIPAL2 SLC17A7 CACNA1I MMP9 ATP12A SLC25A28 ATP4A CYBA

6.48e-06111512020GO:0034220
GeneOntologyBiologicalProcessbasic amino acid transport

SLC38A4 SLC7A7 SLC7A6 SLC7A4

7.35e-06221204GO:0015802
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

NIPAL4 HIF1A DRD2 CACNA2D2 SLC38A4 SLC40A1 SLC6A1 SLC6A8 SLC6A11 SCN4A NIPAL2 SLC17A7 CACNA1I MMP9 ATP12A SLC25A28 ATP4A CYBA

8.49e-0694212018GO:0098655
GeneOntologyBiologicalProcessmonoatomic cation transport

NIPAL4 HIF1A DRD2 CACNA2D2 SLC38A4 SLC40A1 SLC6A1 SLC6A8 SLC6A11 SCN4A SLC10A6 NIPAL2 PKP2 SLC17A7 CACNA1I MMP9 ATP12A SLC25A28 ATP4A CYBA

1.12e-05115712020GO:0006812
GeneOntologyBiologicalProcessmulticellular organismal-level chemical homeostasis

ABCA3 ABCA12 TMPRSS6 EXT2 SLC40A1 ADGRF5

1.43e-05901206GO:0140962
GeneOntologyBiologicalProcessamino acid transport

SLC38A4 SLC7A7 SLC7A6 SLC6A1 SLC6A8 SLC6A11 SLC7A4 SLC17A7

1.88e-051951208GO:0006865
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

NIPAL4 HIF1A DRD2 CACNA2D2 SLC38A4 SLC40A1 SLC6A1 SLC6A8 SLC6A11 CLCN1 SCN4A NIPAL2 SLC17A7 CACNA1I ATP12A SLC25A28 ATP4A CYBA

2.37e-05101712018GO:0098660
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

NIPAL4 HIF1A DRD2 CACNA2D2 SLC38A4 SLC40A1 SLC6A1 SLC6A8 SLC6A11 SCN4A NIPAL2 SLC17A7 CACNA1I ATP12A SLC25A28 ATP4A CYBA

2.45e-0592212017GO:0098662
GeneOntologyBiologicalProcesscarboxylic acid transport

DRD2 SLC38A4 SLC7A7 SLC7A6 SLC22A7 SLC6A1 SLC6A8 SLC6A11 SLC22A13 SLC10A6 SLC17A7

2.79e-0541012011GO:0046942
GeneOntologyBiologicalProcessorganic acid transport

DRD2 SLC38A4 SLC7A7 SLC7A6 SLC22A7 SLC6A1 SLC6A8 SLC6A11 SLC22A13 SLC10A6 SLC17A7

2.92e-0541212011GO:0015849
GeneOntologyBiologicalProcesscell-cell adhesion

CLDN18 SDK2 ITCH ABCA12 NT5E CDHR3 ITGA2 TENM2 CNTN6 CELSR1 ENTPD1 IZUMO1 PKP2 ALCAM SIGLEC1 SDK1 NCK2 CD276

5.02e-05107712018GO:0098609
GeneOntologyBiologicalProcessamino acid transmembrane transport

SLC38A4 SLC7A7 SLC7A6 SLC6A11 SLC7A4 SLC17A7

7.28e-051201206GO:0003333
GeneOntologyBiologicalProcessL-arginine transmembrane transport

SLC38A4 SLC7A7 SLC7A6

8.30e-05151203GO:1903826
GeneOntologyBiologicalProcessiron import into the mitochondrion

HIF1A SLC25A28

2.00e-0441202GO:0048250
GeneOntologyBiologicalProcessgamma-aminobutyric acid reuptake

SLC6A1 SLC6A11

2.00e-0441202GO:0051936
GeneOntologyBiologicalProcessorganic anion transport

DRD2 SLC38A4 SLC7A7 SLC7A6 SLC22A7 SLC6A1 SLC6A8 SLC6A11 SLC22A13 SLC10A6 SLC17A7

2.12e-0451512011GO:0015711
GeneOntologyBiologicalProcesssodium ion homeostasis

DRD2 EXT2 ATP12A ATP4A

2.20e-04511204GO:0055078
GeneOntologyBiologicalProcesscollagen metabolic process

HIF1A TMPRSS6 DDR2 ITGA2 MMP9 MMP15

2.30e-041481206GO:0032963
GeneOntologyBiologicalProcessregulation of body fluid levels

HIF1A DRD2 KALRN EXT2 ITGA2 F5 PTPRO ENTPD1 ENTPD2 CYBA

2.63e-0444212010GO:0050878
GeneOntologyBiologicalProcesssurfactant homeostasis

ABCA3 ABCA12 ADGRF5

4.02e-04251203GO:0043129
GeneOntologyBiologicalProcessorganic acid transmembrane transport

SLC38A4 SLC7A7 SLC7A6 SLC6A8 SLC6A11 SLC17A7

4.39e-041671206GO:1903825
GeneOntologyBiologicalProcessnegative regulation of glomerular filtration

PTPRO CYBA

4.96e-0461202GO:0003105
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

CLDN18 SDK2 CDHR3 TENM2 CNTN6 CELSR1 ALCAM SDK1

4.97e-043131208GO:0098742
GeneOntologyCellularComponentpotassium:proton exchanging ATPase complex

ATP12A ATP4A

9.44e-0531182GO:0005889
GeneOntologyCellularComponentapical part of cell

LGMN DDR2 SLC22A7 SLC6A8 PTPRO SLC22A13 PTPRQ ADGRF5 C1QTNF5 ATP12A ATP4A CYBA

1.32e-0459211812GO:0045177
GeneOntologyCellularComponentlamellar body membrane

ABCA3 ABCA12

1.88e-0441182GO:0097232
GeneOntologyCellularComponentapical plasma membrane

DDR2 SLC22A7 SLC6A8 PTPRO SLC22A13 PTPRQ C1QTNF5 ATP12A ATP4A CYBA

4.43e-0448711810GO:0016324
GeneOntologyCellularComponentsynaptic membrane

DRD2 CACNA2D2 PSENEN NT5E TENM2 CNTN6 SLC6A1 SLC6A8 SLC6A11 PTPRO ENTPD1

4.67e-0458311811GO:0097060
GeneOntologyCellularComponentpresynapse

DRD2 KALRN CACNA2D2 PSENEN CDHR3 ITGA2 SLC35F1 SLC40A1 CNTN6 SLC6A1 SLC6A11 TNN ENTPD1 SLC17A7

4.75e-0488611814GO:0098793
GeneOntologyCellularComponentplasma membrane protein complex

DRD2 CACNA2D2 PSENEN CDHR3 ITGA2 SSPOP TRBV7-4 SCN4A CACNA1I ALCAM ATP12A ATP4A CYBA

4.93e-0478511813GO:0098797
DomainBACK

KBTBD6 KLHL32 KLHL9 KBTBD4 KLHL13

2.98e-05601125SM00875
DomainBACK

KBTBD6 KLHL32 KLHL9 KBTBD4 KLHL13

3.23e-05611125IPR011705
DomainBACK

KBTBD6 KLHL32 KLHL9 KBTBD4 KLHL13

3.23e-05611125PF07707
Domain-

SDK2 KALRN NXPE1 PTGFRN CNTN6 TGM1 PTPRO TNN IZUMO1 ADGRF5 ALCAM SIGLEC1 SDK1 CD276

4.26e-05663112142.60.40.10
DomainAA_permease_2

SLC7A7 SLC7A6 SLC7A4

5.75e-05131123PF13520
DomainAA/rel_permease1

SLC7A7 SLC7A6 SLC7A4

5.75e-05131123IPR002293
DomainIg-like_fold

SDK2 KALRN NXPE1 PTGFRN CNTN6 TGM1 PTPRO TNN IZUMO1 ADGRF5 ALCAM SIGLEC1 SDK1 CD276

8.36e-0570611214IPR013783
DomainIGc2

SDK2 KALRN CNTN6 ADGRF5 ALCAM SIGLEC1 SDK1 CD276

8.61e-052351128SM00408
DomainIg_sub2

SDK2 KALRN CNTN6 ADGRF5 ALCAM SIGLEC1 SDK1 CD276

8.61e-052351128IPR003598
DomainGlyco_hydro_20_cat

HEXA HEXD

1.07e-0431122IPR015883
DomainGlyco_hydro_20

HEXA HEXD

1.07e-0431122PF00728
DomainNA_NEUROTRAN_SYMP_2

SLC6A1 SLC6A8 SLC6A11

1.60e-04181123PS00754
DomainSNF

SLC6A1 SLC6A8 SLC6A11

1.90e-04191123PF00209
DomainNa/ntran_symport

SLC6A1 SLC6A8 SLC6A11

1.90e-04191123IPR000175
DomainNA_NEUROTRAN_SYMP_1

SLC6A1 SLC6A8 SLC6A11

1.90e-04191123PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A1 SLC6A8 SLC6A11

1.90e-04191123PS50267
DomainIG

SDK2 KALRN PTGFRN CNTN6 IZUMO1 ADGRF5 ALCAM SIGLEC1 SDK1 CD276

2.23e-0442111210SM00409
DomainIg_sub

SDK2 KALRN PTGFRN CNTN6 IZUMO1 ADGRF5 ALCAM SIGLEC1 SDK1 CD276

2.23e-0442111210IPR003599
DomainFA58C

DDR2 F5 SSPOP

2.58e-04211123SM00231
DomainFA58C_3

DDR2 F5 SSPOP

2.58e-04211123PS50022
DomainFA58C_1

DDR2 F5 SSPOP

2.58e-04211123PS01285
DomainFA58C_2

DDR2 F5 SSPOP

2.58e-04211123PS01286
DomainGlycoside_hydrolase_SF

HEXA GALC HEXD MGAM2

2.86e-04531124IPR017853
DomainAA-permease/SLC12A_dom

SLC7A7 SLC7A6 SLC7A4

2.97e-04221123IPR004841
DomainAA_permease

SLC7A7 SLC7A6 SLC7A4

2.97e-04221123PF00324
DomainF5_F8_type_C

DDR2 F5 SSPOP

3.88e-04241123PF00754
DomainFA58C

DDR2 F5 SSPOP

3.88e-04241123IPR000421
DomainKelch

KBTBD6 KLHL32 KLHL9 KLHL13

4.05e-04581124SM00612
Domainfn3

SDK2 KALRN CNTN6 PTPRO TNN SDK1

4.35e-041621126PF00041
DomainMg_trans_NIPA

NIPAL4 NIPAL2

5.26e-0461122IPR008521
DomainMg_trans_NIPA

NIPAL4 NIPAL2

5.26e-0461122PF05653
DomainP-type_ATPase_IIC

ATP12A ATP4A

5.26e-0461122IPR005775
DomainIG_LIKE

SDK2 KALRN PTGFRN CNTN6 IZUMO1 ADGRF5 ALCAM SIGLEC1 SDK1 CD276

7.43e-0449111210PS50835
DomainKelch_1

KBTBD6 KLHL32 KLHL9 KLHL13

8.29e-04701124PF01344
DomainKelch_1

KBTBD6 KLHL32 KLHL9 KLHL13

8.29e-04701124IPR006652
DomainFN3

SDK2 KALRN CNTN6 PTPRO TNN SDK1

8.74e-041851126SM00060
DomainIg-like_dom

SDK2 KALRN PTGFRN CNTN6 IZUMO1 ADGRF5 ALCAM SIGLEC1 SDK1 CD276

8.93e-0450311210IPR007110
DomainNeurexophilin

NXPE1 NXPE2

9.75e-0481122PF06312
DomainNXPH/NXPE

NXPE1 NXPE2

9.75e-0481122IPR026845
DomainGDA1_CD39_NTPase

ENTPD1 ENTPD2

9.75e-0481122IPR000407
DomainGDA1_CD39

ENTPD1 ENTPD2

9.75e-0481122PF01150
DomainGDA1_CD39_NTPASE

ENTPD1 ENTPD2

9.75e-0481122PS01238
DomainIg_I-set

SDK2 KALRN CNTN6 ADGRF5 SIGLEC1 SDK1

1.00e-031901126IPR013098
DomainI-set

SDK2 KALRN CNTN6 ADGRF5 SIGLEC1 SDK1

1.00e-031901126PF07679
Domainig

SDK2 PTGFRN ADGRF5 ALCAM SIGLEC1 CD276

1.00e-031901126PF00047
DomainImmunoglobulin

SDK2 PTGFRN ADGRF5 ALCAM SIGLEC1 CD276

1.00e-031901126IPR013151
DomainBTB

KBTBD6 KLHL32 KLHL9 KBTBD4 KLHL13

1.16e-031311125PF00651
Domain-

HEXA GALC HEXD

1.19e-033511233.20.20.80
DomainFN3

SDK2 KALRN CNTN6 PTPRO TNN SDK1

1.27e-031991126PS50853
DomainGlyco_hydro_catalytic_dom

HEXA GALC HEXD

1.52e-03381123IPR013781
DomainFN3_dom

SDK2 KALRN CNTN6 PTPRO TNN SDK1

1.63e-032091126IPR003961
DomainC2-set_2

ALCAM SIGLEC1 CD276

1.90e-03411123PF08205
DomainCD80_C2-set

ALCAM SIGLEC1 CD276

1.90e-03411123IPR013162
DomainBTB-kelch_protein

KLHL32 KLHL9 KLHL13

2.18e-03431123IPR017096
DomainABC_A

ABCA3 ABCA12

2.26e-03121122IPR026082
DomainLdl_recept_a

TMPRSS6 SSPOP C1QTNF5

2.48e-03451123PF00057
DomainBTB

KBTBD6 KLHL32 KLHL9 KBTBD4 KLHL13

2.78e-031601125PS50097
DomainLDLRA_1

TMPRSS6 SSPOP C1QTNF5

2.98e-03481123PS01209
Domain-

KBTBD6 KLHL32 KBTBD4

2.98e-034811232.120.10.80
DomainLDrepeatLR_classA_rpt

TMPRSS6 SSPOP C1QTNF5

3.16e-03491123IPR002172
DomainLDLa

TMPRSS6 SSPOP C1QTNF5

3.16e-03491123SM00192
DomainLDLRA_2

TMPRSS6 SSPOP C1QTNF5

3.16e-03491123PS50068
Domain-

TMPRSS6 ADGRF5

3.56e-031511223.30.70.960
DomainPept_M10A_Zn_BS

MMP9 MMP15

3.56e-03151122IPR021158
DomainATPase_P-typ_TM_dom

ATP12A ATP4A

4.05e-03161122IPR023298
Domain-

ATP12A ATP4A

4.05e-031611221.20.1110.10
DomainKelch-typ_b-propeller

KBTBD6 KLHL32 KBTBD4

4.39e-03551123IPR015915
DomainATPase_P-typ_cation-transptr_C

ATP12A ATP4A

4.57e-03171122IPR006068
DomainCation_ATPase_C

ATP12A ATP4A

4.57e-03171122PF00689
DomainHemopexin_CS

MMP9 MMP15

4.57e-03171122IPR018486
DomainBTB

KBTBD6 KLHL32 KLHL9 KBTBD4 KLHL13

4.60e-031801125SM00225
DomainCation_ATPase_N

ATP12A ATP4A

5.12e-03181122PF00690
DomainCation_ATPase_N

ATP12A ATP4A

5.12e-03181122SM00831
DomainBTB/POZ_dom

KBTBD6 KLHL32 KLHL9 KBTBD4 KLHL13

5.16e-031851125IPR000210
DomainGal_Oxase/kelch_b-propeller

KBTBD6 KLHL9 KLHL13

5.35e-03591123IPR011043
DomainSKP1/BTB/POZ

KBTBD6 KLHL32 KLHL9 KBTBD4 KLHL13

5.64e-031891125IPR011333
DomainATPase_P-typ_cation-transptr_N

ATP12A ATP4A

5.70e-03191122IPR004014
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

NIPAL4 ABCA3 ABCA12 SLC38A4 SLC7A7 SLC7A6 SLC40A1 SLC22A7 SLC6A1 SLC6A11 CLCN1 SLC10A6 NIPAL2 SLC17A7 LCN9 ATP12A ATP4A

2.61e-066819517MM14985
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC38A4 SLC7A7 SLC7A6 SLC40A1 SLC22A7 SLC6A1 SLC6A11 SLC10A6 SLC17A7 LCN9

4.48e-062389510MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC38A4 SLC7A7 SLC7A6 SLC40A1 SLC22A7 SLC6A1 SLC6A11 SLC10A6 SLC17A7 LCN9

6.69e-062499510M5988
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

NIPAL4 ABCA3 ABCA12 SLC38A4 SLC7A7 SLC7A6 SLC40A1 SLC22A7 SLC6A1 SLC6A11 CLCN1 SLC10A6 NIPAL2 SLC17A7 LCN9 ATP12A ATP4A

7.36e-067369517M27287
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC40A1 SLC22A7 SLC6A1 SLC6A11 SLC10A6

1.58e-0476955MM15072
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC40A1 SLC22A7 SLC6A1 SLC6A11 SLC10A6

2.54e-0484955M27334
PathwayREACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION

SLC6A1 SLC6A11 ALDH5A1

2.66e-0419953MM15523
PathwayREACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION

SLC6A1 SLC6A11 ALDH5A1

2.66e-0419953M927
PathwayREACTOME_NEUROTRANSMITTER_RELEASE_CYCLE

SLC6A1 SLC6A11 SLC17A7 ALDH5A1

3.80e-0451954M4281
PathwayREACTOME_NEUROTRANSMITTER_RELEASE_CYCLE

SLC6A1 SLC6A11 SLC17A7 ALDH5A1

3.80e-0451954MM14499
Pubmed

Evaluation of CD39, CD73, HIF-1α, and their related miRNAs expression in decidua of preeclampsia cases compared to healthy pregnant women.

HIF1A NT5E ENTPD1

4.11e-083121336048381
Pubmed

Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure.

HIF1A NT5E ENTPD1

4.11e-083121327899277
Pubmed

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.

SLC7A6 SLC22A7 SLC6A1 SLC7A4 SLC22A13 SLC10A6 ALDH5A1

9.93e-06212121719521566
Pubmed

Autosomal Recessive Congenital Ichthyosis

NIPAL4 ABCA12 TGM1

1.15e-0513121320301593
Pubmed

Redefining the clinical phenotypes of non-dystrophic myotonic syndromes.

CLCN1 SCN4A

1.20e-052121219211598
Pubmed

Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury.

NT5E ENTPD1

1.20e-052121217548651
Pubmed

Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes.

NT5E ENTPD1

1.20e-052121232707842
Pubmed

CD39 and CD73 in the aortic valve-biochemical and immunohistochemical analysis in valve cell populations and its changes in valve mineralization.

NT5E ENTPD1

1.20e-052121230056298
Pubmed

Mineralocorticoids stimulate the activity and expression of renal H+,K+-ATPases.

ATP12A ATP4A

1.20e-052121221164026
Pubmed

Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region.

HIF1A TMPRSS6

1.20e-052121222628316
Pubmed

A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance.

SLC7A7 SLC7A6

1.20e-052121215756301
Pubmed

A novel founder SCN4A mutation causes painful cold-induced myotonia in French-Canadians.

CLCN1 SCN4A

1.20e-052121217998485
Pubmed

Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas.

NT5E ENTPD1

1.20e-052121223737488
Pubmed

Expression and clinical significance of CD73 and hypoxia-inducible factor-1α in gastric carcinoma.

HIF1A NT5E

1.20e-052121223569336
Pubmed

CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages.

NT5E ENTPD1

1.20e-052121229103803
Pubmed

Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy.

SDK2 SDK1

1.20e-052121215213259
Pubmed

CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression.

NT5E ENTPD1

1.20e-052121226226423
Pubmed

Characterization of ecto-nucleotidases in human oviducts with an improved approach simultaneously identifying protein expression and in situ enzyme activity.

NT5E ENTPD2

1.20e-052121229273916
Pubmed

Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain.

DRD2 DDR2

1.20e-05212128247548
Pubmed

Altered CD39 and CD73 Expression in Rheumatoid Arthritis: Implications for Disease Activity and Treatment Response.

NT5E ENTPD1

1.20e-052121238275742
Pubmed

Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms.

ATP12A ATP4A

1.20e-052121218057185
Pubmed

Simultaneous overexpression of human E5NT and ENTPD1 protects porcine endothelial cells against H2O2-induced oxidative stress and cytotoxicity in vitro.

NT5E ENTPD1

1.20e-052121228389406
Pubmed

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α.

HIF1A CD276

1.20e-052121227197253
Pubmed

Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs.

NT5E ENTPD1

1.20e-052121218838482
Pubmed

Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling.

ENTPD1 ENTPD2

1.20e-052121215632415
Pubmed

Definition of the critical domains required for homophilic targeting of mouse sidekick molecules.

SDK2 SDK1

1.20e-052121215703275
Pubmed

Ferroportin Is Essential for Iron Absorption During Suckling, But Is Hyporesponsive to the Regulatory Hormone Hepcidin.

TMPRSS6 SLC40A1

1.20e-052121228462381
Pubmed

Architecture of cell-cell adhesion mediated by sidekicks.

SDK2 SDK1

1.20e-052121230150416
Pubmed

Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma.

HIF1A ENTPD2

1.20e-052121228894087
Pubmed

XIAP upregulates expression of HIF target genes by targeting HIF1α for Lys63-linked polyubiquitination.

HIF1A XIAP

1.20e-052121228666324
Pubmed

Functional and Structural Characterization of ClC-1 and Nav1.4 Channels Resulting from CLCN1 and SCN4A Mutations Identified Alone and Coexisting in Myotonic Patients.

CLCN1 SCN4A

1.20e-052121233670307
Pubmed

Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity.

NT5E ENTPD1

1.20e-052121222421436
Pubmed

CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8+ T Cells.

NT5E ENTPD1

1.20e-052121229066514
Pubmed

The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain.

NT5E ENTPD1

1.20e-052121228376099
Pubmed

Is the regulation by miRNAs of NTPDase1 and ecto-5'-nucleotidase genes involved with the different profiles of breast cancer subtypes?

NT5E ENTPD1

1.20e-052121234741235
Pubmed

NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis.

ENTPD1 ENTPD2

1.20e-052121231188623
Pubmed

Non-dystrophic myotonia: prospective study of objective and patient reported outcomes.

CLCN1 SCN4A

1.20e-052121223771340
Pubmed

Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism.

NT5E ENTPD1

1.20e-052121215319286
Pubmed

Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin.

TMPRSS6 SLC40A1

1.20e-052121234838540
Pubmed

HIF-1α/MMP-9 Axis Is Required in the Early Phases of Skeletal Myoblast Differentiation under Normoxia Condition In Vitro.

HIF1A MMP9

1.20e-052121238132171
Pubmed

Coexistence of SCN4A and CLCN1 mutations in a family with atypical myotonic features: A clinical and functional study.

CLCN1 SCN4A

1.20e-052121236720299
Pubmed

Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis.

NT5E ENTPD1

1.20e-052121224266925
Pubmed

HIF-1-Dependent TGM1 Expression is Associated with Maintenance of Airway Epithelial Junction Proteins.

HIF1A TGM1

1.20e-052121227423780
Pubmed

Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation.

ENTPD1 ENTPD2

1.20e-052121211929769
Pubmed

High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors.

NT5E ENTPD1

1.20e-052121224707115
Pubmed

y+LAT1 and y+LAT2 contribution to arginine uptake in different human cell models: Implications in the pathophysiology of Lysinuric Protein Intolerance.

SLC7A7 SLC7A6

1.20e-052121231705628
Pubmed

A novel murine myotonia congenita without molecular defects in the ClC-1 and the SCN4A.

CLCN1 SCN4A

1.20e-052121212370472
Pubmed

3p25.3 microdeletion of GABA transporters SLC6A1 and SLC6A11 results in intellectual disability, epilepsy and stereotypic behavior.

SLC6A1 SLC6A11

1.20e-052121225256099
Pubmed

ENTPD1 (CD39) and NT5E (CD73) expression in human glioblastoma: an in silico analysis.

NT5E ENTPD1

1.20e-052121237402102
Pubmed

Sequence CLCN1 and SCN4A genes in patients with nondystrophic myotonia in Chinese people.

CLCN1 SCN4A

1.20e-052121235866763
Pubmed

Hypoxia promotes invasion of retinoblastoma cells in vitro by upregulating HIF-1α/MMP9 signaling pathway.

HIF1A MMP9

1.20e-052121229243776
Pubmed

Monitoring and characterizing soluble and membrane-bound ectonucleotidases CD73 and CD39.

NT5E ENTPD1

1.20e-052121231652269
Pubmed

HIF-1α and CD73 expression in cardiac leukocytes correlates with the severity of myocarditis in end-stage Chagas disease patients.

HIF1A NT5E

1.20e-052121232450615
Pubmed

Immune cell expression patterns of CD39/CD73 ectonucleotidases in rodent models of cardiac arrest and resuscitation.

NT5E ENTPD1

1.20e-052121238545102
Pubmed

High-Throughput Screening Assays for Cancer Immunotherapy Targets: Ectonucleotidases CD39 and CD73.

NT5E ENTPD1

1.20e-052121231868071
Pubmed

Human platelets express functional ectonucleotidases that restrict platelet activation signaling.

NT5E ENTPD1

1.20e-052121232446352
Pubmed

In tandem analysis of CLCN1 and SCN4A greatly enhances mutation detection in families with non-dystrophic myotonia.

CLCN1 SCN4A

1.20e-052121218337730
Pubmed

Double trouble in a patient with myotonia.

CLCN1 SCN4A

1.20e-052121223417379
Pubmed

Benzamil-mediated urine alkalization is caused by the inhibition of H+-K+-ATPases.

ATP12A ATP4A

1.20e-052121233554781
Pubmed

Oxidized low-density lipoproteins enhance expression and activity of CD39 and CD73 in the human aortic valve endothelium.

NT5E ENTPD1

1.20e-052121227906627
Pubmed

CD39-mediated effect of human bone marrow-derived mesenchymal stem cells on the human Th17 cell function.

NT5E ENTPD1

1.20e-052121224043462
Pubmed

Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73).

NT5E ENTPD1

1.20e-052121237055675
Pubmed

Myotonia congenita: mutation spectrum of CLCN1 in Spanish patients.

CLCN1 SCN4A

1.20e-052121231544778
Pubmed

Non-dystrophic myotonia Chilean cohort with predominance of the SCN4A Gly1306Glu variant.

CLCN1 SCN4A

1.20e-052121232593548
Pubmed

Role of the CD39/CD73 Purinergic Pathway in Modulating Arterial Thrombosis in Mice.

NT5E ENTPD1

1.20e-052121227417582
Pubmed

Novel mutations in TGM1 and ABCA12 cause autosomal recessive congenital ichthyosis in five Saudi families.

ABCA12 TGM1

1.20e-052121227061915
Pubmed

GAT-1 (rs2697153) and GAT-3 (rs2272400) polymorphisms are associated with febrile seizures and temporal lobe epilepsy.

SLC6A1 SLC6A11

1.20e-052121232301730
Pubmed

Activity and expression of E-NTPDase is altered in peripheral lymphocytes of systemic lupus erythematosus patients.

NT5E ENTPD1

1.20e-052121230409763
Pubmed

Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole.

NIPAL4 TGM1

1.20e-052121219197536
Pubmed

Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice.

NT5E ENTPD1

1.20e-052121218256308
Pubmed

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.

HIF1A MMP9

1.20e-052121218328425
Pubmed

Transcriptional upregulation of MT2-MMP in response to hypoxia is promoted by HIF-1α in cancer cells.

HIF1A MMP15

1.20e-052121221751260
Pubmed

Resident cardiac immune cells and expression of the ectonucleotidase enzymes CD39 and CD73 after ischemic injury.

NT5E ENTPD1

1.20e-052121222514659
Pubmed

Protein Tyrosine Phosphatase PTPRO Signaling Couples Metabolic States to Control the Development of Granulocyte Progenitor Cells.

HIF1A PTPRO

1.20e-052121235246496
Pubmed

Variability in CD39 and CD73 protein levels in uveal melanoma patients.

NT5E ENTPD1

1.20e-052121235199627
Pubmed

Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina.

SDK2 SDK1

1.20e-052121212230981
Pubmed

Oridonin inhibits hypoxia-induced epithelial-mesenchymal transition and cell migration by the hypoxia-inducible factor-1α/matrix metallopeptidase-9 signal pathway in gallbladder cancer.

HIF1A MMP9

1.20e-052121231517732
Pubmed

Susceptibility of aging mice to listeriosis: Role of anti-inflammatory responses with enhanced Treg-cell expression of CD39/CD73 and Th-17 cells.

NT5E ENTPD1

1.20e-052121231974050
Pubmed

Immunocytochemical localization of NTPDases1 and 2 in the neural retina of mouse and zebrafish.

ENTPD1 ENTPD2

1.20e-052121219116950
Pubmed

CD73 on T Cells Orchestrates Cardiac Wound Healing After Myocardial Infarction by Purinergic Metabolic Reprogramming.

NT5E ENTPD1

1.20e-052121228432149
Pubmed

The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy.

NT5E ENTPD1

1.20e-052121236776866
Pubmed

CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages.

NT5E ENTPD1

1.20e-052121228060378
Pubmed

Regulation of immune responses through CD39 and CD73 in cancer: Novel checkpoints.

NT5E ENTPD1

1.20e-052121234265363
Pubmed

Sequence CLCN1 and SCN4A in patients with Nondystrophic myotonias in Chinese populations: Genetic and pedigree analysis of 10 families and review of the literature.

CLCN1 SCN4A

1.20e-052121227415035
Pubmed

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.

HIF1A NT5E

1.20e-052121234650224
Pubmed

Hippocampal GABA transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis.

SLC6A1 SLC6A11

1.20e-052121226212582
Pubmed

Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production.

NT5E ENTPD1

1.20e-052121221677139
Pubmed

Molecular basis of sidekick-mediated cell-cell adhesion and specificity.

SDK2 SDK1

1.20e-052121227644106
Pubmed

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.

SDK2 TENM2 CNTN6 ALCAM SDK1

1.72e-0591121528558017
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

KALRN PTGFRN CNTN6 ADGRF5 ALCAM SIGLEC1

2.30e-05162121625826454
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HEXA KALRN MYO9B KHNYN AOC2 KDM3B MIB2 SLC6A8 CELSR1 ADAMTSL5 ENTPD2 CTSZ NCK2 CD276

3.17e-0511051211435748872
Pubmed

Chronic cerebral hypoperfusion-induced impairment of Aβ clearance requires HB-EGF-dependent sequential activation of HIF1α and MMP9.

HIF1A MMP9

3.59e-053121227431094
Pubmed

Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID.

NT5E ENTPD1

3.59e-053121222184407
Pubmed

Feedback regulation of ALDOA activates the HIF-1α/MMP9 axis to promote lung cancer progression.

HIF1A MMP9

3.59e-053121228610954
Pubmed

Altered E-NTPDase/E-ADA activities and CD39 expression in platelets of sickle cell anemia patients.

NT5E ENTPD1

3.59e-053121227044834
Pubmed

Summary of mutations underlying autosomal recessive congenital ichthyoses (ARCI) in Arabs with four novel mutations in ARCI-related genes from the United Arab Emirates.

ABCA12 TGM1

3.59e-053121228236338
Pubmed

Expression of functional inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 by astrocytes of inferior colliculus and hippocampus.

SLC6A1 SLC6A11

3.59e-053121229370841
Pubmed

A critical influence of HIF-1 on MMP-9 and Galectin-3 in oral lichen planus.

HIF1A MMP9

3.59e-053121238951854
Pubmed

Role of HIF-1α-activated Epac1 on HSC-mediated neuroplasticity in stroke model.

HIF1A MMP9

3.59e-053121223702312
Pubmed

Mutation spectrum and health status in skeletal muscle channelopathies in Japan.

CLCN1 SCN4A

3.59e-053121232660787
GeneFamilySolute carriers

SLC38A4 SLC35F1 SLC7A7 SLC7A6 SLC40A1 SLC22A7 SLC6A1 SLC6A8 SLC6A11 SLC7A4 SLC22A13 SLC10A6 SLC17A7 SLC25A28

8.99e-093959014752
GeneFamilyFibronectin type III domain containing

SDK2 KALRN CNTN6 PTPRO TNN PTPRQ SDK1

1.50e-05160907555
GeneFamilyATPase H+/K+ transporting

ATP12A ATP4A

7.33e-0539021211
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

SDK2 KALRN CNTN6 ADGRF5 SIGLEC1 SDK1

1.53e-04161906593
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KBTBD6 KLHL32 KLHL9 KBTBD4 KLHL13

5.51e-04134905861
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

ALCAM SIGLEC1 CD276

1.03e-0340903592
GeneFamilyKelch like|BTB domain containing

KLHL32 KLHL9 KLHL13

1.19e-0342903617
GeneFamilyATP binding cassette subfamily A

ABCA3 ABCA12

2.14e-0314902805
GeneFamilyImmunoglobulin like domain containing

SDK2 PTGFRN ADGRF5 ALCAM SDK1

2.78e-03193905594
GeneFamilyADAM metallopeptidase domain containing|CD molecules

NT5E ITGA2 PTGFRN ENTPD1 ALCAM SIGLEC1 CD276

3.51e-03394907471
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRO PTPRQ

4.84e-0321902813
GeneFamilyEndogenous ligands|Matrix metallopeptidases

MMP9 MMP15

6.30e-0324902891
GeneFamilyCalcium voltage-gated channel subunits

CACNA2D2 CACNA1I

7.37e-0326902253
GeneFamilyAdenosine receptors|V-set domain containing

PTGFRN ALCAM SIGLEC1 CD276

8.93e-03163904590
GeneFamilyImmunoglobulin lambda locus at 22q11.2

IGLV5-48 IGLV5-45 IGLV5-39

9.95e-0389903353
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HEXA LGMN HIF1A SLC7A7 SLC40A1 SIGLEC1 MARCO CTSZ CYBA

3.59e-0920011992cca77b2c9d829daa674a844e068f2b083e90d6e
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

F5 CNTN6 SLC6A11 PTPRQ BUB1 SIGLEC1 ATP12A MARCO

1.33e-081621198bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DPP7 LGMN SLC7A7 ADAMTSL5 SIGLEC1 MARCO CTSZ CD276

3.73e-0818511980e8064bb317f26959d3c59b4f73d0c455161ccd7
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LGMN HIF1A SLC7A7 SLC40A1 SIGLEC1 MARCO CTSZ CYBA

6.56e-081991198f965eb89d6d023c83154276b8fded490fd89c100
ToppCellBronchial-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CHIT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

HEXA LGMN SLC7A7 SIGLEC1 MMP9 MARCO CTSZ CD276

6.56e-08199119854a54ad983503ed515d476882d86b17d97892037
ToppCellE16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT2_Precursor|E16.5-samps / Age Group, Lineage, Cell class and subclass

CLDN18 ABCA3 ADAMTSL5 NIPAL2 ADGRF5 ALCAM ATP4A

2.04e-0715511979cad73d0b8ead289e1073d1a2e00bbeb1228308c
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CLDN18 SLC7A7 GALNT18 TGM1 PKP2 ALCAM MMP9

2.75e-07162119734b4cd3d2258f88dfbd6d32abd1db87aff8a6b6f
ToppCellnormal_Lung-Epithelial_cells-Undetermined|normal_Lung / Location, Cell class and cell subclass

CLDN18 ABCA3 CACNA2D2 SNX25 ADGRF5 MARCO CTSZ

2.99e-071641197fa2dae15b38cb8f9642dbf00549beec8ee19e9bb
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEXA LGMN SLC40A1 PTPRO SIGLEC1 CTSZ CYBA

4.13e-071721197f0e767a20d93e546ce278db67dbd779cc68af533
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CLDN18 ABCA3 GALNT18 SLC6A1 CELSR1 PKP2 ALCAM

4.29e-07173119745808cf69122c16b9d2b5ffa06d15392c55954b7
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CLDN18 ABCA3 GALNT18 SLC6A1 CELSR1 PKP2 ALCAM

4.29e-0717311977fa9dbcb258c3ab974490063951620e2def03db1
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEXA LGMN SLC40A1 PTPRO SIGLEC1 CTSZ CYBA

4.46e-071741197f520b79d277e286c9bb5d091e6c94e7ec7e46699
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DPP7 HEXA LGMN HIF1A MARCO CTSZ CYBA

4.46e-071741197062e7bd9072ca7ee68e09b1da28af13f1bc60b44
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXA LGMN SLC40A1 ENTPD1 SIGLEC1 MARCO CYBA

5.82e-071811197a93df1ba23d5b5f249491d69d12bfc0e274dafcf
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTN6 SLC6A1 SLC6A11 PKP2 LCN9 ALCAM SDK1

5.82e-071811197154d5e586cab25155c6d06dfe6ae01203b88e0fb
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SLC7A7 TGM1 SLC7A4 PLLP ENTPD2 PTPRQ PKP2

7.24e-0718711978e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|368C / Donor, Lineage, Cell class and subclass (all cells)

LGMN SLC40A1 ENTPD1 ALCAM SIGLEC1 CTSZ CYBA

8.06e-071901197cbba3d94a4c3e0b0d14f3b7c60dba5d6e097c5e3
ToppCellCOVID-19-lung-Macrophage_metabolically_active|COVID-19 / Disease (COVID-19 only), tissue and cell type

LGMN MYO9B ALCAM SIGLEC1 MARCO CTSZ CYBA

9.92e-0719611971b7928f4eee94d4bb6ea410bab68a471dba12979
ToppCellASK440-Epithelial-Type_1|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

CLDN18 GALNT18 CNTN6 TGM1 SLC7A4 PLLP ALCAM

1.03e-0619711971eda2c2504451a3d626dda5c2b2b12eeaa6bca54
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HEXA LGMN HIF1A SLC7A7 MARCO CTSZ CYBA

1.06e-061981197eb0a94c426a7c567f94490b848e28784587c6dcd
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO9B SLC7A7 PTPRO ENTPD1 SIGLEC1 MARCO CTSZ

1.06e-0619811970b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HEXA LGMN SLC7A7 SLC40A1 MMP9 MARCO CTSZ

1.06e-061981197641e7be258303bb9782d19fcf8693f317581d3b8
ToppCellBronchial-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA3 CACNA2D2 ST7 CELSR1 SNX25 ADGRF5 ALCAM

1.10e-0619911975f7da3eab58ace6cddb3179a415cd839d5767958
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA3 CACNA2D2 ST7 CELSR1 SNX25 ADGRF5 ALCAM

1.10e-0619911975cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LGMN SLC40A1 SIGLEC1 MMP9 MARCO CTSZ CYBA

1.10e-061991197e1066e638af83ba5e89c7cabb8ad00b6bcdee5f4
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LGMN HIF1A SLC7A7 SIGLEC1 MARCO CTSZ CYBA

1.10e-061991197994e885b8d1874006302a081d13f1ee881d64612
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LGMN SLC40A1 SIGLEC1 MMP9 MARCO CTSZ CYBA

1.10e-061991197ca0f6526ba0dcf8789dd3b583291519626427f2f
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CLDN18 ABCA3 ITGA2 CNTN6 PLLP CELSR1 PTPRQ

1.10e-061991197a270630626df614f8605abddb7dee7c4d74f6149
ToppCellBronchial-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

HEXA LGMN SLC7A7 ALCAM SIGLEC1 MARCO CTSZ

1.14e-062001197ea039de8bd8b325845ce361f84e600c6dad922ed
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_other|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LGMN SLC7A7 ALCAM SIGLEC1 MMP9 MARCO CTSZ

1.14e-062001197eac46978e2b3d38cf42b44f7b0350d0489d036b3
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CNTN6 SLC6A11 PTPRQ BUB1 ATP12A MARCO

2.60e-06145119696712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellnormal_Lymph_Node-Myeloid_cells-mo-Mac|Myeloid_cells / Location, Cell class and cell subclass

LGMN SLC40A1 SNX25 SIGLEC1 MMP9 CTSZ

3.54e-0615311965424494ea1f09542799045a875cc3eac13de5079
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLDN18 KLHL32 CNTN6 TGM1 PLLP PTPRQ

4.11e-0615711969665a1375cfd8e9b8781c852686591226c0e0d9a
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CLDN18 ABCA3 CACNA2D2 SLC6A11 SNX25 ALCAM

4.42e-061591196e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NT5E DDR2 SLC6A1 PTPRO KLHL13 ATP12A

4.42e-0615911960dccc4275b9b4f8554dd556da7218e130bff8fd1
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CLDN18 GALNT18 TGM1 PKP2 ALCAM MMP9

5.10e-06163119656b8668dbf06faa6866ec71f29b92907b73f074d
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEXA LGMN GALC SLC40A1 SIGLEC1 MMP9

5.47e-06165119647e716ce8dc283d406352c1909e09362fcb9e3a3
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEXA LGMN GALC SLC40A1 SIGLEC1 MMP9

5.47e-061651196fe2135fdacf3807eb4b5ea5e790febfb8cd54335
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HEXA ACOX1 AOC2 SLC6A11 MARCO CYBA

6.07e-061681196eba865465feb0f42055bb8f98946050eeb03d177
ToppCellP28-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CLDN18 SLC7A7 WDR19 ALCAM ALDH5A1 SDK1

6.07e-0616811968c8dbdbc7053f34e4ca0c5067af502fbea109fc1
ToppCell367C-Epithelial_cells-Epithelial-B_(AT2)|367C / Donor, Lineage, Cell class and subclass (all cells)

CLDN18 ABCA3 CACNA2D2 PLLP SNX25 ADGRF5

6.07e-061681196e20e1936573fdde78426d7a4eb45c458d5c4dbb4
ToppCell367C-Epithelial_cells-Epithelial-B_(AT2)-|367C / Donor, Lineage, Cell class and subclass (all cells)

CLDN18 ABCA3 CACNA2D2 PLLP SNX25 ADGRF5

6.07e-06168119616b517e3159ad6e6d25fd48f7d5f46e77b2b318d
ToppCellfacs-Liver-Non-hepatocytes-3m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN SLC40A1 SLC6A1 ENTPD1 SIGLEC1 MARCO

6.28e-0616911960f5e737b265ba333275a0cd289dab029a1542075
ToppCellfacs-Liver-Non-hepatocytes-3m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN SLC40A1 SLC6A1 ENTPD1 SIGLEC1 MARCO

6.28e-061691196aec1b4c7e973a31c53aaea47c2c05d24ce16aa4f
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_4|390C / Donor, Lineage, Cell class and subclass (all cells)

MYO9B WDR19 PTPRO SIGLEC1 MARCO CTSZ

6.49e-061701196439167e44a1bd5ac8e1e457351dd202ec968db46
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-6|TCGA-Bladder / Sample_Type by Project: Shred V9

ABCA12 PTGFRN TENM2 TGM1 CELSR1 SLC10A6

6.72e-0617111960e78389f8f3d54570a6deb3dd307b865b46307e9
ToppCellControl-Epithelial_cells-Airway_basal|Control / group, cell type (main and fine annotations)

ITGA2 SLC6A1 CAPN13 CELSR1 PTPRQ SDK1

6.72e-0617111963965ced4be6db14265a90673502fceee425837ca
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLDN18 ABCA3 TSPEAR CNTN6 PLLP CELSR1

7.42e-061741196d0e3d15731de6c19c232e3aa492c39d8151cf4ed
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXA LGMN SLC40A1 ENTPD1 SIGLEC1 MARCO

7.42e-061741196dc4298c1d9359f7e37454e9451f889017227d5cf
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HEXA LGMN SLC7A7 SIGLEC1 MARCO CTSZ

8.18e-061771196382f0d6bbff01e84b0c7840e74ac865864e6da89
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TSPEAR F5 TENM2 PTPRO SNX25 PTPRQ

8.18e-0617711964d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ITGA2 SLC6A1 CAPN13 CELSR1 PTPRQ SDK1

8.18e-061771196cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ITGA2 SLC6A1 CAPN13 CELSR1 PTPRQ SDK1

8.18e-061771196ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCellControl-Epithelial_alveolar-AT_1-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLDN18 KLHL32 CNTN6 CELSR1 PTPRQ ALCAM

8.18e-0617711969af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCellControl-Epithelial_alveolar-AT_1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLDN18 CNTN6 PLLP CELSR1 PTPRQ ALCAM

8.45e-061781196aa7d43c655df493f1330a5001efaa484e4a19f69
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TSPEAR F5 TENM2 PTPRO SNX25 PTPRQ

8.45e-061781196edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ITGA2 GALNT18 PLLP ENTPD1 CRYBG1 ADGRF5

8.45e-061781196c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LGMN SLC7A7 SLC40A1 NIPAL2 SIGLEC1 CTSZ

9.00e-0618011966f8fa9fa91cd25b92584972bb34d90c483222f52
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTN6 SLC6A1 SLC6A11 ACSM4 PKP2 SDK1

9.59e-061821196d3a037268f026eb2f84428b1821022503cef7756
ToppCellControl-Epithelial-Basal|Control / Disease state, Lineage and Cell class

ITGA2 SLC6A1 CAPN13 CELSR1 PTPRQ SDK1

9.59e-061821196caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA3 TSPEAR GALNT18 CELSR1 TMEM232 MMP9

9.59e-061821196f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HEXA SLC7A7 PTPRO SIGLEC1 MARCO CTSZ

9.89e-061831196103c4c4595d8daa677679fd2fa1e99cd398e56dd
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSPEAR F5 TENM2 PTPRO SNX25 PTPRQ

9.89e-061831196612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSPEAR F5 TENM2 PTPRO SNX25 PTPRQ

9.89e-061831196eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLDN18 ABCA3 CNTN6 PLLP CELSR1 PTPRQ

9.89e-061831196ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSPEAR F5 TENM2 PTPRO SNX25 PTPRQ

9.89e-0618311967c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KALRN ABCA12 SLC35F1 SSPOP PTPRQ SDK1

1.02e-0518411962cbed6462fea2622871bb7e49b0df3d984239281
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CLDN18 GALNT18 CNTN6 CAPN13 PTPRQ ALCAM

1.02e-05184119657c792e6e2fedba25d3350ffe649fd74750b579d
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KALRN ABCA12 SLC35F1 SSPOP PTPRQ SDK1

1.02e-051841196ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLDN18 ABCA3 ITGA2 CNTN6 PLLP CELSR1

1.02e-051841196cdf6f1c6cce97a7effa0c55959652e2c0b6992b3
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KALRN ABCA12 SLC35F1 SSPOP PTPRQ SDK1

1.02e-0518411962b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CLDN18 GALNT18 CNTN6 CAPN13 PTPRQ ALCAM

1.02e-051841196d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TSPEAR F5 TENM2 PTPRO SNX25 PTPRQ

1.05e-0518511969197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TSPEAR F5 TENM2 PTPRO SNX25 PTPRQ

1.05e-051851196ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTN6 SLC6A1 ACSM4 KLHL13 PKP2 SDK1

1.05e-0518511960b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TSPEAR F5 TENM2 PTPRO SNX25 PTPRQ

1.05e-051851196b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLDN18 LGMN ABCA3 CACNA2D2 SNX25 ADGRF5

1.05e-0518511967460387f48f33674330bd53b759681b264228f5a
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLDN18 ITGA2 CNTN6 PLLP CELSR1 PTPRQ

1.08e-0518611963aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ITGA2 SLC35F1 CNTN6 ENTPD2 ALCAM MMP15

1.08e-0518611966f88b68735d0f7c9904eb8413e6007910d556185
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KALRN ST7 SLC35F1 TENM2 SLC6A1 SDK1

1.08e-0518611964780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCellEpithelial-alveolar_epithelial_cell_type_1|World / Lineage, Cell type, age group and donor

CLDN18 GALNT18 CNTN6 PLLP CELSR1 PTPRQ

1.08e-05186119609d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCell10x5'-Liver-Myeloid_Dendritic-DC1|Liver / Manually curated celltypes from each tissue

LGMN ABCA12 IZUMO1 PKP2 SDK1 CTSZ

1.08e-051861196e823529ffd06352c6bdec102f221fdf27f7c7369
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLDN18 ABCA3 CACNA2D2 TM9SF1 SNX25 ADGRF5

1.12e-0518711967c44cec1c26ca5907a495f2d7e633410e2e9728f
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CLDN18 ABCA3 CACNA2D2 SNX25 ADGRF5 ALCAM

1.12e-0518711965df9e1f5ca32217af255e76e6fb5afa346337811
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 SDK2 TSPEAR ITGA2 CNTN6 CELSR1

1.12e-05187119658d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCellnormal_Lymph_Node-Myeloid_cells-mo-Mac|normal_Lymph_Node / Location, Cell class and cell subclass

LGMN SLC7A7 SLC40A1 SIGLEC1 MMP9 CTSZ

1.15e-051881196e83de94a9b47a6a90e98face887eae031a322af6
ToppCell5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NT5E TSPEAR SSPOP GALNT18 IZUMO1 ADGRF5

1.15e-051881196524a12f433c7b6f33fad36c0716afa06cd3235e9
ToppCell5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NT5E TSPEAR SSPOP GALNT18 IZUMO1 ADGRF5

1.15e-051881196d2610b81b3c7f22977b5e2137b1f61410fc4ef16
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LGMN SLC7A7 ALCAM MARCO CTSZ CD276

1.19e-0518911960a490730cdc912d5233de59057550de0e4065747
ToppCell(7)_Epithelial-D_(AT2)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

CLDN18 ABCA3 CACNA2D2 PLLP SNX25 ADGRF5

1.22e-051901196832d6d3ad14665e50623afe1b8586ccae1a97de5
ToppCellfacs-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLDN18 ABCA3 SLC38A4 CELSR1 SNX25 ALCAM

1.26e-051911196c06bbad24e4897b2c3b5015e4de02411ebf75367
ToppCellfacs-Lung-nan-3m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLDN18 ABCA3 SLC38A4 CELSR1 SNX25 ALCAM

1.26e-0519111965f43f98cfe7a08d61ed55f34808fabfe47f1ac2e
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

LGMN SLC40A1 PTPRO ENTPD1 SIGLEC1 CTSZ

1.26e-05191119624d75b7e1d6fb9d24aa7844f584ee888a449841f
ToppCellCOVID-19-lung-Macrophage_PPARGhi_CD5Lhi|lung / Disease (COVID-19 only), tissue and cell type

MYO9B PTPRO ALCAM SIGLEC1 MARCO CTSZ

1.26e-051911196dab953682b8c9ed680a799161f837f792a7e4f33
ToppCellfacs-Lung-EPCAM-3m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLDN18 ABCA3 SLC38A4 CELSR1 SNX25 ALCAM

1.26e-051911196629007189034ee8451411428f1c6cc57daee2d91
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LGMN ENTPD1 MMP9 CTSZ NCK2 CYBA

1.26e-051911196b5715eeb72a97b7bc87b83f6c289e225f58da842
ToppCellwk_08-11-Mesenchymal-Mesothelial-intermediate_mesothelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SLC7A7 TGM1 SLC7A4 PLLP ENTPD2 PTPRQ

1.30e-051921196ac9e5288ecd4b1e142f2e15a1fcd11c8eb9e15cd
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

ABCA3 CACNA2D2 CELSR1 SNX25 ADGRF5 ALCAM

1.30e-051921196499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCelldroplet-Lung-3m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CLDN18 ABCA3 CELSR1 SNX25 ADGRF5 MMP15

1.30e-05192119613e4b17d7a592604140777aca235f795df6b3f91
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC7A7 PTPRO SIGLEC1 MARCO CTSZ CYBA

1.30e-051921196fb0d05a2c83816794652a6e5af8713e9bb22d5db
DrugBM212

NT5E ITGA2 ALCAM

4.33e-0671153CID000456926
Drugchlorine cation

ITGA2 SLC6A1 SLC6A11

4.33e-0671153CID006857643
Drugalpha-estradiol; Up 200; 0.01uM; MCF7; HT_HG-U133A

DRD2 SCN4A BUB1 SLC17A7 CACNA1I ADGRF5 SIGLEC1 CTSZ

8.16e-0620011585570_UP
Drugmosapride

DRD2 SLC6A1 SLC6A11 TGM1

8.47e-06261154CID000119583
DrugBBCH

SLC7A7 SLC7A6 SLC6A1 SLC6A11

9.91e-06271154CID000115288
DrugAC1LA6XN

DPP7 SLC6A1 SLC6A11

1.03e-0591153CID000462826
Drug3-dimethylaminobenzoic acid

AOC2 EPX TGM1

1.47e-05101153CID000066837
Druglithium chromate

HEXA DRD2 ABCA12 NT5E SLC38A4 ITGA2 SLC6A1 TGM1 SLC17A7

1.98e-052961159CID000026627
Druggastrodin

SLC6A1 SLC6A11 ALDH5A1

2.01e-05111153CID000115067
Drug3-nitro-4-hydroxyphenylacetic acid

GALC DRD2 ITCH SLC6A1 SLC6A11 BUB1

2.25e-051121156CID000447364
Drugacetonitrile anion

ABCA12 TGM1

2.53e-0521152CID003015105
Drugbeta-homoproline

SLC6A1 SLC6A11

2.53e-0521152CID000123784
DrugM209-7

ACOX1 TGM1

2.53e-0521152CID000079417
DrugI Tax

DRD2 SLC6A1 SLC6A11

2.67e-05121153CID000003792
Drugbenzohydroxamic acid

HEXA ACOX1 EPX CYBA

2.87e-05351154CID000010313
Drug1-Naphthylisothiocyanate

DPP7 LGMN HIF1A GALC IARS1 ACOX1 F5 SLC22A7 PTPRO NIPAL2 MMP9 MMP15 CTSZ CD276 CYBA

3.31e-0587111515ctd:D015058
Drugaldosterone

LGMN CACNA2D2 SLC7A6 SAR1A SCN4A CACNA1I C1QTNF5 MMP9 MMP15 CYBA

3.40e-0539711510CID000005839
Drugsipatrigine

SLC6A1 SLC6A11 SCN4A SLC17A7

3.59e-05371154CID000060803
DrugMonobenzone [103-16-2]; Down 200; 20uM; MCF7; HT_HG-U133A

NT5E PLLP PTPRO BUB1 ALCAM MMP15 ALDH5A1

4.52e-0518611573391_DN
DrugEvoxine [522-11-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A

KALRN EPX SLC22A7 CLCN1 PTPRO PKP2 SIGLEC1

6.50e-0519711576041_UP
Drug8-bromo-ATP

ITGA2 ENTPD1 ENTPD2

6.70e-05161153CID003082217
Drug(+/-)-verapamil hydrochloride; Up 200; 10uM; MCF7; HG-U133A

ST7 TMPRSS6 EXT2 SLC7A6 CACNA1I ALCAM SIGLEC1

6.71e-051981157161_UP
Drugtetraethylenepentamine pentahydrochloride; Down 200; 100uM; PC3; HG-U133A

TMPRSS6 AOC2 F5 PLLP KBTBD4 SLC17A7 SIGLEC1

6.93e-051991157457_DN
DrugASPAN

SLC6A1 SLC6A11

7.56e-0531152CID005475577
DrugAC1LUEYS

NT5E ACOX1

7.56e-0531152CID001629204
DrugGaba-Glu

SLC6A1 SLC6A11

7.56e-0531152CID000129795
Drug2,5-dimethyltetrahydrofuran

ITGA2 TGM1

7.56e-0531152CID000013855
Drugglutathione monoester

CLDN18 HIF1A MYO9B SLC40A1 MMP9

7.57e-05861155CID000452938
DiseaseCongenital Nonbullous Ichthyosiform Erythroderma

NIPAL4 ABCA12 TGM1

9.55e-06111163C0079154
DiseaseCongenital ichthyosis of skin

NIPAL4 ABCA12 TGM1

9.55e-06111163cv:C0020758
DiseaseMyotonia Congenita

CLCN1 SCN4A

1.53e-0521162C0027127
DiseaseMyotonia Levior

CLCN1 SCN4A

1.53e-0521162C0270959
DiseaseBecker Generalized Myotonia

CLCN1 SCN4A

1.53e-0521162C0751360
DiseaseGeneralized Myotonia of Thomsen

CLCN1 SCN4A

1.53e-0521162C2936781
Diseaseeye colour measurement

DRD2 MIB2 SLC7A7 CNTN6 CELSR1 CRYBG1 ALCAM

2.57e-052181167EFO_0009764
Diseasethrombosis (is_implicated_in)

ITGA2 F5 MMP9

2.60e-05151163DOID:0060903 (is_implicated_in)
DiseaseRetinal Vein Occlusion

ITGA2 F5

4.58e-0531162C0035328
Diseasemeningococcal meningitis (biomarker_via_orthology)

MMP9 MARCO

4.58e-0531162DOID:0080176 (biomarker_via_orthology)
DiseaseThrombosis of retinal vein

ITGA2 F5

4.58e-0531162C1527411
DiseaseHyperkalemic periodic paralysis

CLCN1 SCN4A

4.58e-0531162C0238357
Diseaseepilepsy (implicated_via_orthology)

KALRN CACNA2D2 SCN4A ATP12A ALDH5A1 ATP4A

4.66e-051631166DOID:1826 (implicated_via_orthology)
DiseaseIchthyosis Congenita I

ABCA12 TGM1

9.15e-0541162C4551630
DiseaseHarlequin Fetus

ABCA12 TGM1

9.15e-0541162C0239849
DiseaseIchthyosis Congenita II

ABCA12 TGM1

9.15e-0541162C3536797
Diseaseautosomal recessive congenital ichthyosis 1 (is_implicated_in)

ABCA12 TGM1

9.15e-0541162DOID:0060656 (is_implicated_in)
DiseaseCollodion Fetus

ABCA12 TGM1

9.15e-0541162C3543867
DiseaseCongenital ichthyosis

ABCA12 TGM1

1.52e-0451162C0020758
Diseasecardiovascular measurement

SLC35F1 TMEM232

2.27e-0461162EFO_0004298
DiseaseMyotonia

CLCN1 SCN4A

2.27e-0461162C0027125
DiseaseLiver Cirrhosis, Experimental

DPP7 LGMN GALC NT5E PTPRO NIPAL2 MMP9 MMP15 CTSZ CD276 CYBA

2.44e-0477411611C0023893
Diseasefamilial hemiplegic migraine (implicated_via_orthology)

ATP12A ATP4A

3.18e-0471162DOID:0060178 (implicated_via_orthology)
Diseaseatrial natriuretic factor measurement

DRD2 CRYBG1

3.18e-0471162EFO_0004789
Diseaseretinal vein occlusion (is_implicated_in)

ITGA2 F5

3.18e-0471162DOID:1727 (is_implicated_in)
Diseaseretinal ischemia (biomarker_via_orthology)

HIF1A MMP9

3.18e-0471162DOID:12510 (biomarker_via_orthology)
Diseasebrain ischemia (implicated_via_orthology)

HIF1A SLC6A1 MMP9

3.53e-04351163DOID:2316 (implicated_via_orthology)
Diseasemyocardial infarction (is_implicated_in)

HIF1A ITGA2 F5 MMP9

6.40e-04991164DOID:5844 (is_implicated_in)
Diseaseplatelet component distribution width

KALRN MYO9B TMPRSS6 ITGA2 TNN ENTPD1 ADGRF5 SIGLEC1 CTSZ NCK2

8.09e-0475511610EFO_0007984
Diseasedisease progression measurement, Crohn's disease

CDHR3 ALDH5A1 SDK1

8.46e-04471163EFO_0000384, EFO_0008336
Diseaseiron biomarker measurement

TMPRSS6 SLC40A1 KLHL13

9.00e-04481163EFO_0004461
DiseaseHepatic fibrosis

SDK2 ATP12A SDK1

9.56e-04491163HP_0001395
Diseasenervous system disease (implicated_via_orthology)

ATP12A ATP4A

9.86e-04121162DOID:863 (implicated_via_orthology)
Diseaseskin melanoma (is_marker_for)

HIF1A MMP9

1.16e-03131162DOID:8923 (is_marker_for)
DiseaseLeft ventricular noncompaction

MIB2 PKP2

1.35e-03141162C1960469
Diseaseacute graft vs. host disease, donor genotype effect measurement

KALRN SDK1

1.56e-03151162EFO_0004599, EFO_0007892
DiseaseWithdrawal Symptoms

DRD2 SLC6A1 MMP9

1.56e-03581163C0087169
DiseaseDrug Withdrawal Symptoms

DRD2 SLC6A1 MMP9

1.56e-03581163C0086189
DiseaseSubstance Withdrawal Syndrome

DRD2 SLC6A1 MMP9

1.56e-03581163C0038587
Diseasepre-eclampsia (is_marker_for)

HIF1A ENTPD1 MMP9

1.56e-03581163DOID:10591 (is_marker_for)
DiseaseBrain Ischemia

HIF1A F5 MMP9

1.72e-03601163C0007786
DiseaseCerebral Ischemia

HIF1A F5 MMP9

1.72e-03601163C0917798
DiseaseSeizures

GALC DRD2 KDM3B SLC6A1 SLC17A7

1.74e-032181165C0036572
Diseasecholesteatoma of middle ear (is_marker_for)

HIF1A MMP9

1.77e-03161162DOID:10964 (is_marker_for)
Diseasecalcium/calmodulin-dependent protein kinase type 1 measurement

F5 SLC25A28

1.77e-03161162EFO_0008062
DiseasePolyposis, Adenomatous Intestinal

F5 MUTYH

1.77e-03161162C2713442
DiseaseFamilial Intestinal Polyposis

F5 MUTYH

1.77e-03161162C2713443
DiseaseAdenomatous Polyposis Coli

F5 MUTYH

2.00e-03171162C0032580
Diseaseiron biomarker measurement, ferritin measurement

TMPRSS6 SLC40A1

2.51e-03191162EFO_0004459, EFO_0004461
Diseasestroke

KALRN GALNT18 SLC22A7 CRYBG1

2.55e-031441164EFO_0000712
Diseaseiron biomarker measurement, transferrin measurement

TMPRSS6 SLC40A1

2.78e-03201162EFO_0004461, EFO_0006341
Diseasetemporal lobe epilepsy (is_marker_for)

SLC6A1 MMP9

2.78e-03201162DOID:3328 (is_marker_for)
DiseaseIdiopathic Pulmonary Fibrosis

HIF1A ABCA3

3.06e-03211162C1800706
DiseaseAlzheimer disease

CLDN18 CDHR3 TENM2 FNIP1 ALCAM SDK1 NCK2

3.11e-034851167MONDO_0004975
Diseasetransient cerebral ischemia (biomarker_via_orthology)

HIF1A ENTPD1 SLC17A7 MMP9

3.48e-031571164DOID:224 (biomarker_via_orthology)
Diseasecolorectal cancer (is_marker_for)

HIF1A KDM3B XIAP MMP9

3.48e-031571164DOID:9256 (is_marker_for)
DiseaseDisproportionate short stature

DDR2 EXT2 MMP9

3.50e-03771163C0878659
Diseasetotal iron binding capacity

TMPRSS6 F5 SLC40A1

3.63e-03781163EFO_0006334

Protein segments in the cluster

PeptideGeneStartEntry
DNWTDAEGYYRVNIG

PRPF4B

666

Q13523
YGARQYDQGVDLWSV

CDK20

176

Q8IZL9
PWNYQIDYFGVAATV

BUB1

981

O43683
AIRNYTLWRVGDYGS

CTSZ

181

Q9UBR2
LWQVFGSATGVTRYY

CACNA2D2

246

Q9NY47
RQGWQRYYFEGIKQT

AHSA1

316

O95433
QYIARYEEQGIGLQW

ABCA12

1221

Q86UK0
YQENFYAWSAPGVGR

ABCA3

1291

Q99758
EQWRVQTGLELYEGY

ACSM4

356

P0C7M7
YTVTGAEQIQYRRGW

CAPN13

251

Q6MZZ7
YRGYPEAEVFWQDGQ

CD276

386

Q5ZPR3
TGSVRSQEDQWYLGY

CCDC144CP

26

Q8IYA2
GVSDGRWHSVQVQYY

CELSR1

1521

Q9NYQ6
ADAFYQRGYRWAGFI

SLC7A4

306

O43246
GQERFWTITSSYYRG

RAB1C

66

Q92928
QSQQYLYWDGERRTY

RBM10

601

P98175
VSAFFSYQAWRGVGS

PLLP

156

Q9Y342
VRSVSSVGNYDYIWD

AOC2

456

O75106
FFSGRQVWVYTGASV

MMP9

581

P14780
AGREWYYGNVTRHQA

NCK2

281

O43639
GINVGTYRIYWYQQK

IGLV5-39

46

A0A0G2JS06
GYIRIWGVNTYVTQV

MGAM2

1751

Q2M2H8
YVGWRNESATNGYIE

DDR2

256

Q16832
RGGYVWVETQATVIY

HIF1A

311

Q16665
WTGYTAFFVGILVQQ

ATP12A

931

P54707
YWRFNEETQRGDPGY

MMP15

486

P51511
RNYNVARVSGVWYSI

LCN9

26

Q8WX39
IVATAGRFTQWYFGA

CYBA

26

P13498
GRFTQWYFGAYSIVA

CYBA

31

P13498
GVFGWVTANYLLENF

ENTPD2

166

Q9Y5L3
ELFDYGLQQYWGSRA

PERCC1

176

A0A1W2PR82
SAFFASWRIVYEGGI

EPX

501

P11678
SGYTVEYREEGSQIW

KALRN

2601

O60229
QGIILTGWQRYDHYS

HEXD

291

Q8WVB3
WQNEGAGAFYRSYTT

SLC25A28

216

Q96A46
RLYEEYGVQGWAIVQ

KDM3B

1661

Q7LBC6
AVFENKIYVVGGYSW

KLHL9

541

Q9P2J3
GQEEGAYGWITINYL

ENTPD1

171

P49961
YFVNVTTRIWNGTFA

ITGA2

1071

P17301
VFRDAGAFAGYWNVT

ADAMTSL5

206

Q6ZMM2
AYTEQSQIKGYVWRS

PSENEN

46

Q9NZ42
YEVAYQAEAGWFSQR

NUP155

236

O75694
KYNVFTRVNISYWEG

PTPRO

146

Q16827
WYRFQVAASTNAGYG

PTPRQ

1551

Q9UMZ3
GWEQRVDQHGRVYYV

ITCH

331

Q96J02
LGRYDGNVYENLFEW

ACOX1

621

Q15067
ENKIYVVGGYSWNNR

KLHL13

586

Q9P2N7
WVQVGVGDYIGIYAS

C1QTNF5

206

Q9BXJ0
AFRVNWLSGTYFEVV

CDHR3

71

Q6ZTQ4
TRQVSSYYGGEQEDW

FNIP1

956

Q8TF40
LGLYFGEQAYLRSSW

CACNA1I

1226

Q9P0X4
WVTNYIASVYVRGQE

GALNT18

31

Q6P9A2
NTGRVLGYEVLYWTD

CNTN6

831

Q9UQ52
NRGRAEVYYSGTWGT

MARCO

431

Q9UEW3
YFSSRGIAIAVQYFW

KHNYN

456

O15037
EGLTDYSFYRVWGNN

IZUMO1

191

Q8IYV9
YSFYRVWGNNTETLV

IZUMO1

196

Q8IYV9
VLYSAFTWLGYVNSA

DRD2

406

P14416
RSVQVIGGIWVTYEY

CRYBG1

1536

Q9Y4K1
FFWIFANGSYRVTGD

GALC

596

P54803
VVVWFGVNFSYYGLS

SLC22A7

351

Q9Y694
WFVDSLGYYGLSLQV

SLC22A13

341

Q9Y226
IITGYQISWEVYGRN

SDK1

1001

Q7Z5N4
IQGYKIYFWEAQRGN

SDK2

1656

Q58EX2
LGWYTVNSAYGDTII

ALCAM

26

Q13740
YNTGWVLCQIGRAYF

CDC27

496

P30260
QTRYTFGAALFVGWV

CLDN18

166

P56856
DSYGQEWTFGQRLYQ

ATP4A

911

P20648
FLQGAYDTVRWEFGT

DPP7

231

Q9UHL4
YEYDIRGDQWINIGT

KBTBD6

586

Q86V97
NGTYLVSFTLFWEGQ

NXPE1

161

Q8N323
WDQGTRTNYRAGYQG

MIB2

56

Q96AX9
DIVSSYGKGYVVWQE

HEXA

361

P06865
GISVGSYRIYWYQQK

IGLV5-48

46

A0A075B6I7
SGEANVRFTVSWYYR

PTGFRN

436

Q9P2B2
ISWFYGVNRFYDNIQ

SLC6A1

471

P30531
LAGYFYSQDPAQIWR

ALDH5A1

466

P51649
ALRQYYFTVGWNIFD

SCN4A

1406

P35499
YSFWGGQGCRYSLVQ

SSPOP

581

A2VEC9
LRQFYVAAQGISWSY

F5

31

P12259
GINVGTYRIYWYQQK

IGLV5-45

46

A0A087WSX0
NNGTYLVSFTLFWEG

NXPE2

171

Q96DL1
YILSWYGNLSRDEGQ

SNX25

16

Q9H3E2
NAVIYYRVGDNVWTE

KBTBD4

346

Q9NVX7
QAISARTVQYYLVGW

NIPAL2

166

Q9H841
VWNQRYFVISNTTGY

FNTA

236

P49354
EWIYNGFSSVLQFLG

SAR1A

6

Q9NR31
RDGWVSYYNQPVFLA

SLC40A1

296

Q9NP59
NKASGWSVQYRYDGV

TENM2

2291

Q9NT68
EVNQLWAGLGYYSRG

MUTYH

166

Q9UIF7
GVLVQYSGWSSVFYV

SLC17A7

226

Q9P2U7
FGNIVCYNWYGDGRI

WDR19

231

Q8NEZ3
FIAEGIDQTRGWFYT

IARS1

556

P41252
WIDAGTQIFFSYAIG

SLC6A8

306

P48029
TGEWYLNGNYLIIFV

SLC38A4

191

Q969I6
NLFRGAEYNRYTWVT

ST7

141

Q9NRC1
QYQGTIWFTVYKGAE

NT5E

86

P21589
EVYWNTSAGIKIYQR

ADGRF5

501

Q8IZF2
LVGYITNYSRRFWQG

CHAC2

21

Q8WUX2
EVTSTYFAVRNYWRG

CLCN1

291

P35523
GATLYGISNVWEEYI

SLC35F1

226

Q5T1Q4
EARIFTFGTWIYSVN

XIAP

266

P98170
AYKVYVWAERGNQGS

TNN

506

Q9UQP3
CDQVVWTGYYGLVYN

TMEM232

426

C9JQI7
LFGRVYTLSTAGQYW

TECPR1

11

Q7Z6L1
SFSYWFFVGLSIVGQ

SLC7A7

386

Q9UM01
GFSTWTYRQGYDVSI

EXT2

216

Q93063
CIGWVYGSNRFYDNI

SLC6A11

486

P48066
VAFGVYVNYRWPKQS

SLC10A6

176

Q3KNW5
VGFIYGYVAEQFGWT

SPCS1

101

Q9Y6A9
FNTGALYTQIGTWRY

RHPN2P1

136

A8MT19
TAIWYYDYSGQRQVV

SIGLEC1

56

Q9BZZ2
WQERIRQNYGFYIGL

NIPAL4

46

Q0D2K0
SYWFFVGLSVVGQLY

SLC7A6

396

Q92536
YYGTEAQIGERTWNY

TGM1

276

P22735
FSVNSIIYRWQGYEG

TSPEAR

611

Q8WU66
IIYRWQGYEGFVAVH

TSPEAR

616

Q8WU66
GATYFQRGSLFWFTV

TMEM254

6

Q8TBM7
TATYEGRWGRGTAQY

PKP2

116

Q99959
SGHVTLYWYRQTLGQ

TRBV7-4

46

A0A1B0GX95
FATVWGREQYTLYGI

TM9SF1

486

O15321
NYFGVYTRITGVISW

TMPRSS6

791

Q8IU80
NGRIYLVGGYSIWTN

KLHL32

546

Q96NJ5
VVIVAGSNGWYNYRH

LGMN

31

Q99538
RTQAAVYLQASWRGY

MYO9B

1001

Q13459