Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin binding

TRPM7 MYO9B TMOD4 TMOD2 INO80 SHTN1 ERMN LRPPRC SYNE2 SCNN1A TMOD1 WASF1 FMNL1 PHACTR1

2.72e-0647912914GO:0003779
GeneOntologyMolecularFunctioncytoskeletal protein binding

KIFBP ANK2 TRPM7 MYO9B TMOD4 TMOD2 INO80 SHTN1 DYSF ERMN LRPPRC SLC8A1 SYNE2 SCNN1A TMOD1 KIF13A WASF1 FMNL1 TBCD PHACTR1

2.53e-05109912920GO:0008092
GeneOntologyMolecularFunctiontropomyosin binding

TMOD4 TMOD2 TMOD1

1.13e-04151293GO:0005523
GeneOntologyBiologicalProcesspointed-end actin filament capping

TMOD4 TMOD2 TMOD1

7.65e-0671263GO:0051694
GeneOntologyBiologicalProcessactin filament-based process

WASHC2C ANK2 TRPM7 MYO9B OBSL1 TMOD4 TMOD2 SHTN1 WASHC2A ERMN SYNE2 SCN10A TMOD1 PRKCI WASF1 FMNL1 PHACTR1

4.04e-0591212617GO:0030029
GeneOntologyBiologicalProcessregulation of protein depolymerization

NES WASHC2C TMOD4 TMOD2 DYSF TMOD1

4.53e-051051266GO:1901879
GeneOntologyCellularComponentnuclear ubiquitin ligase complex

BCOR PCGF6 CDC26 ANAPC2 BUB1B

1.70e-05491375GO:0000152
GeneOntologyCellularComponentsupramolecular fiber

NES ANK2 MYO9B DNAH2 OBSL1 TMOD4 TMOD2 HAUS3 INO80 SHTN1 DYSF DNAH7 CEP170 LRPPRC SLC8A1 SYNE2 TMOD1 KIF13A TBCD AHNAK2

8.58e-05117913720GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

NES ANK2 MYO9B DNAH2 OBSL1 TMOD4 TMOD2 HAUS3 INO80 SHTN1 DYSF DNAH7 CEP170 LRPPRC SLC8A1 SYNE2 TMOD1 KIF13A TBCD AHNAK2

9.40e-05118713720GO:0099081
GeneOntologyCellularComponentsarcomere

ANK2 OBSL1 TMOD4 TMOD2 SLC8A1 SYNE2 TMOD1 AHNAK2

2.42e-042491378GO:0030017
GeneOntologyCellularComponentanaphase-promoting complex

CDC26 ANAPC2 BUB1B

4.43e-04231373GO:0005680
GeneOntologyCellularComponentmyofibril

ANK2 OBSL1 TMOD4 TMOD2 SLC8A1 SYNE2 TMOD1 AHNAK2

4.47e-042731378GO:0030016
GeneOntologyCellularComponentcontractile muscle fiber

ANK2 OBSL1 TMOD4 TMOD2 SLC8A1 SYNE2 TMOD1 AHNAK2

6.65e-042901378GO:0043292
GeneOntologyCellularComponentmicrotubule associated complex

DNAH2 HAUS3 SHTN1 DNAH7 KIF13A PEA15

6.81e-041611376GO:0005875
GeneOntologyCellularComponentstriated muscle thin filament

TMOD4 TMOD2 TMOD1

7.18e-04271373GO:0005865
GeneOntologyCellularComponentmicrotubule

DNAH2 HAUS3 INO80 SHTN1 DYSF DNAH7 CEP170 LRPPRC SLC8A1 KIF13A TBCD

7.85e-0453313711GO:0005874
GeneOntologyCellularComponentmyofilament

TMOD4 TMOD2 TMOD1

1.19e-03321373GO:0036379
GeneOntologyCellularComponentfilopodium

RIPOR2 MYO9B SHTN1 ERMN SYNE2

1.31e-031231375GO:0030175
DomainDUF1220

NBPF3 NBPF11 NBPF1 NBPF15 NBPF9 NBPF14

4.99e-11111326PF06758
DomainNBPF_dom

NBPF3 NBPF11 NBPF1 NBPF15 NBPF9 NBPF14

4.99e-11111326IPR010630
DomainNBPF

NBPF3 NBPF11 NBPF1 NBPF15 NBPF9 NBPF14

4.99e-11111326PS51316
DomainDUF1220

NBPF3 NBPF11 NBPF1 NBPF15 NBPF9

2.01e-0991325SM01148
DomainTMOD

TMOD4 TMOD2 TMOD1

1.18e-0571323IPR004934
DomainTropomodulin

TMOD4 TMOD2 TMOD1

1.18e-0571323PF03250
DomainFAM21

WASHC2C WASHC2A

4.96e-0521322IPR027308
DomainCAP-ZIP_m

WASHC2C WASHC2A

1.48e-0431322PF15255
DomainTEX13

TEX13B TEX13A

1.48e-0431322PF15186
DomainTEX13

TEX13B TEX13A

1.48e-0431322IPR028193
DomainFAM21/CAPZIP

WASHC2C WASHC2A

1.48e-0431322IPR029341
DomainTRPM_tetra

TRPM7 TRPM1

2.95e-0441322PF16519
DomainTRPM_tetra

TRPM7 TRPM1

2.95e-0441322IPR032415
DomainP-loop_NTPase

BRIP1 ABCA4 SEPTIN4 VWA8 MYO9B ZGRF1 DNAH2 CARD10 CHST1 INO80 DNAH7 AK3 IQCB1 RAD54B GNL2 KIF13A

3.23e-0484813216IPR027417
DomainAlpha_kinase

TRPM7 ALPK1

7.30e-0461322PF02816
DomainMHCK_EF2_kinase

TRPM7 ALPK1

7.30e-0461322IPR004166
DomainALPHA_KINASE

TRPM7 ALPK1

7.30e-0461322PS51158
DomainAlpha_kinase

TRPM7 ALPK1

7.30e-0461322SM00811
DomainBromodomain_CS

BRPF3 BAZ1A TAF1L

7.97e-04261323IPR018359
DomainFHA

CEP170 MDC1 KIF13A

9.93e-04281323SM00240
DomainFHA_DOMAIN

CEP170 MDC1 KIF13A

1.34e-03311323PS50006
DomainFHA

CEP170 MDC1 KIF13A

1.34e-03311323PF00498
DomainTMC

TMC1 TMC6

1.35e-0381322PF07810
DomainCalx_beta

ITGB4 SLC8A1

1.35e-0381322SM00237
DomainTMC

TMC1 TMC6

1.35e-0381322IPR012496
DomainCalx_beta

ITGB4 SLC8A1

1.73e-0391322IPR003644
DomainBEN

BEND6 BANP

1.73e-0391322PS51457
DomainBEN

BEND6 BANP

1.73e-0391322SM01025
DomainBEN

BEND6 BANP

1.73e-0391322PF10523
DomainBEN_domain

BEND6 BANP

1.73e-0391322IPR018379
DomainCalx-beta

ITGB4 SLC8A1

1.73e-0391322PF03160
Domain-

CEP170 MDC1 KIF13A

2.08e-033613232.60.200.20
DomainFHA_dom

CEP170 MDC1 KIF13A

2.08e-03361323IPR000253
DomainBROMODOMAIN_1

BRPF3 BAZ1A TAF1L

2.25e-03371323PS00633
Domain-

BRIP1 ABCA4 SEPTIN4 VWA8 ZGRF1 DNAH2 CARD10 CHST1 INO80 DNAH7 AK3 RAD54B GNL2

2.42e-03746132133.40.50.300
DomainBromodomain

BRPF3 BAZ1A TAF1L

2.43e-03381323PF00439
DomainBROMODOMAIN_2

BRPF3 BAZ1A TAF1L

3.02e-03411323PS50014
DomainBromodomain

BRPF3 BAZ1A TAF1L

3.24e-03421323IPR001487
DomainBROMO

BRPF3 BAZ1A TAF1L

3.24e-03421323SM00297
Domain-

BRPF3 BAZ1A TAF1L

3.24e-034213231.20.920.10
DomainDynein_heavy_chain_D4_dom

DNAH2 DNAH7

4.27e-03141322IPR024317
DomainDynein_HC_stalk

DNAH2 DNAH7

4.27e-03141322IPR024743
DomainDynein_heavy_dom-2

DNAH2 DNAH7

4.27e-03141322IPR013602
DomainDHC_N2

DNAH2 DNAH7

4.27e-03141322PF08393
DomainATPase_dyneun-rel_AAA

VWA8 DNAH2

4.27e-03141322IPR011704
DomainMT

DNAH2 DNAH7

4.27e-03141322PF12777
DomainAAA_8

DNAH2 DNAH7

4.27e-03141322PF12780
DomainAAA_5

VWA8 DNAH2

4.27e-03141322PF07728
Domain-

ANK2 CARD10 IRAK4 PEA15

4.28e-039313241.10.533.10
DomainDHC_fam

DNAH2 DNAH7

4.90e-03151322IPR026983
DomainDynein_heavy

DNAH2 DNAH7

4.90e-03151322PF03028
DomainDynein_heavy_dom

DNAH2 DNAH7

4.90e-03151322IPR004273
DomainDEATH-like_dom

ANK2 CARD10 IRAK4 PEA15

5.35e-03991324IPR011029
DomainSMAD_FHA_domain

CEP170 MDC1 KIF13A

5.92e-03521323IPR008984
DomainZnf_RING_CS

RC3H2 RNF17 TRIM10 PCGF6 PDZRN3

6.05e-031631325IPR017907
Pubmed

A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.

NBPF3 NBPF8 NBPF12 NBPF11 NBPF20 NBPF1 NBPF19 NBPF15 NBPF9 NBPF10 NBPF14

9.46e-22211391116079250
Pubmed

Evolutionary history and genome organization of DUF1220 protein domains.

NBPF8 NBPF12 NBPF1 NBPF15 NBPF9 NBPF14

7.58e-1310139622973535
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

NES STAM2 TRPM7 ALPK1 SHTN1 TRIP11 DNAH7 CEP170 LRPPRC BMPR2 SLF2 MAP4K1 SYNE2 IQCB1 BUB1B PRKCI BOD1L1 RAPGEF2 PLCH1 KIF13A AHNAK2

3.74e-118611392136931259
Pubmed

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

NBPF8 NBPF12 NBPF11 DNAH7 NBPF1 NBPF9 SYNE2 NBPF10 NBPF14 UNC79

1.85e-091701391023314748
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

STAM2 WASHC2C ANK2 BCOR SHTN1 TRIP11 CEP170 USP14 SNW1 BAZ1A CIAPIN1 BUB1B CYB5R3 FAM169A GNL2 BOD1L1 CDC5L MTDH AHNAK2

6.76e-099341391933916271
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NES DMXL2 KIFBP ANK2 BCOR SHTN1 TRIP11 CEP170 LRPPRC SNW1 SYNE2 PRKCI FRMPD3 LAMTOR1 CDC5L RAPGEF2 WASF1 UNC79 PHACTR1

1.10e-089631391928671696
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

STAM2 DMXL2 KIFBP ANK2 TRPM7 VWA8 PBDC1 OBSL1 DNAJC7 WASHC2A PCGF6 LRPPRC SNW1 SLC20A1 SYNE2 NUP210 BUB1B GNL2 PRKCI LAMTOR1 CDC5L PLCH1 MTDH

2.59e-0814871392333957083
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ATMIN KCNH8 TMC6 ZNF189 RBBP8NL SHTN1 PCDHB16 NBPF1 CEP170 USP14 LRPPRC BMPR2 AOPEP NUP210 BANP SCNN1A PRKCI BOD1L1 ANKRD12 RAPGEF2 PEA15 TBCD

1.19e-0714891392228611215
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

NES BRIP1 WASHC2A CEP170 USP14 SLC20A1 MDC1 IQCB1 CIAPIN1 BANP GNL2 BOD1L1 CDC5L PLCH1 PDZRN3

2.72e-077331391534672954
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

STAM2 WASHC2C MYO9B ZGRF1 OBSL1 BCOR DNAJC7 WASHC2A TRIP11 SLF2 IQCB1 BANP GID8

7.54e-075881391338580884
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

NBPF8 NBPF12 ZGRF1 NBPF11 ITGB4 NBPF1 NBPF15 NBPF9 MDC1 NBPF10 CDC5L NBPF14

1.14e-065131391225798074
Pubmed

Leiomodins: larger members of the tropomodulin (Tmod) gene family.

TMOD4 TMOD2 TMOD1

1.24e-066139311318603
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

RC3H2 VWA8 DNAH2 CARD10 DNAJC7 RNF17 TRIP11 ZNF12 MDC1 SYNE2 NUP210 TMOD1 KIF13A MTDH

2.17e-067541391435906200
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

STAM2 BCOR DNAJC7 SHTN1 CEP170 USP14 SNW1 MDC1 CIAPIN1 BUB1B BOD1L1 CDC5L

2.30e-065491391238280479
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

KIFBP VWA8 TTC27 CARD10 DNAJC7 CEP170 USP14 LRPPRC MDC1 SYNE2 NUP210 BUB1B GNL2 TMOD1 GID8 LAMTOR1 CDC5L MTDH AHNAK2

4.94e-0614401391930833792
Pubmed

Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver.

TMOD4 TMOD2 TMOD1

5.16e-069139324159174
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

RIPOR2 WASHC2C DZIP1L INO80 BCOR WASHC2A ITGB4 BAZ1A AOPEP SLC20A1 IRAK4 BOD1L1 ANKRD12 KIF13A MTDH PHACTR1

7.45e-0610841391611544199
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ATMIN VWA8 MYO9B TMC6 LAD1 CARD10 INO80 DYSF WASHC2A ZBTB42 SLC29A2 ITGB4 NBPF1 BANP TBCD AHNAK2

9.45e-0611051391635748872
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

SP100 WASHC2C BCOR PPWD1 CEP170 SNW1 SLF2 CDC5L MTDH AHNAK2

1.28e-054441391034795231
Pubmed

Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice.

SLC26A4 SCNN1A

1.59e-052139217686956
Pubmed

Role of tropomodulin's leucine rich repeat domain in the formation of neurite-like processes.

TMOD2 TMOD1

1.59e-052139224746171
Pubmed

Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).

WASHC2C WASHC2A

1.59e-052139220827171
Pubmed

Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B.

ANK2 SLC8A1

1.59e-052139217178715
Pubmed

FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.

WASHC2C WASHC2A

1.59e-052139236717248
Pubmed

Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers.

NBPF11 NBPF1

1.59e-05213927700633
Pubmed

Identification of a novel Rev-interacting cellular protein.

WASHC2C WASHC2A

1.59e-052139215847701
Pubmed

Pendrin modulates ENaC function by changing luminal HCO3-.

SLC26A4 SCNN1A

1.59e-052139220966128
Pubmed

Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.

TMOD4 TMOD1

1.59e-052139226586224
Pubmed

Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers.

TMOD4 TMOD1

1.59e-052139224072783
Pubmed

Integrin β4 promotes cell invasion and epithelial-mesenchymal transition through the modulation of Slug expression in hepatocellular carcinoma.

ITGB4 SNAI2

1.59e-052139228084395
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

NES MYO9B OBSL1 DNAJC7 CEP170 LRPPRC SNW1 BAZ1A SLC20A1 MDC1 SYNE2 NUP210 GNL2 CDC5L MTDH

1.60e-0510241391524711643
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

TRPM7 SHTN1 TRIP11 CEP170 USP14 SYNE2 CIAPIN1 LAMTOR1 MTDH FMNL1 AHNAK2

1.90e-055681391137774976
Pubmed

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

CDC26 ANAPC2 BUB1B

2.74e-0515139323007861
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

DMXL2 ANK2 PCDH12 DYSF TRIP11 CEP170 PCGF6 LRPPRC SYNE2 IL6ST

3.34e-054971391023414517
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

BRIP1 INO80 BCOR ZNF12 PCGF6 BAZ1A MDC1 RAD54B FAM169A GNL2 BOD1L1

3.54e-056081391136089195
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

RC3H2 HAUS3 INO80 DYSF WASHC2A CEP170 PCGF6 SNW1 CIAPIN1 PEA15 MTDH AHNAK2

3.63e-057241391236232890
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

DMXL2 KIFBP BRPF3 CLUAP1 ABCA4 TMC1 WASHC2C HMX3 TMC6 PBDC1 ALPK1 WASHC2A C3orf20 LRPPRC TMOD1 CFAP61

3.90e-0512421391630973865
Pubmed

The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments.

TMOD4 TMOD1

4.75e-053139211016930
Pubmed

Sodium channels and mammalian sensory mechanotransduction.

SCN10A SCNN1A

4.75e-053139222449024
Pubmed

Human INO80 chromatin-remodelling complex contributes to DNA double-strand break repair via the expression of Rad54B and XRCC3 genes.

INO80 RAD54B

4.75e-053139220687897
Pubmed

SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.

SNW1 ANAPC2

4.75e-053139225257309
Pubmed

Pendrin gene ablation alters ENaC subcellular distribution and open probability.

SLC26A4 SCNN1A

4.75e-053139225972513
Pubmed

Faster regeneration associated to high expression of Fam65b and Hdac6 in dysferlin-deficient mouse.

RIPOR2 DYSF

4.75e-053139231218594
Pubmed

Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs.

TMOD4 TMOD2

4.75e-053139210662549
Pubmed

Immunohistochemical analysis of NKX2.2, ETV4, and BCOR in a large series of genetically confirmed Ewing sarcoma family of tumors.

BCOR NKX2-2

4.75e-053139228864350
Pubmed

Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle.

TMOD4 TMOD1

4.75e-053139224430868
Pubmed

Molecular and cytogenetic characterization of two azoospermic patients with X-autosome translocation.

TEX13B TEX13A

4.75e-053139214531651
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

DMXL2 RIPOR2 ITGB4 BAZ1A SYNE2 SCN10A ANKRD12 TBCD

4.88e-05322139826514267
Pubmed

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.

CDC26 ANAPC2 BUB1B

4.88e-0518139311535616
Pubmed

The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit.

CDC26 ANAPC2 BUB1B

4.88e-0518139314593737
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

DMXL2 WASHC2C ANK2 VWA8 SNRK WASHC2A AK3 CEP170 LRPPRC CYB5R3 FAM169A GID8 WASF1 MTDH PHACTR1

5.40e-0511391391536417873
Pubmed

APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box.

CDC26 ANAPC2 BUB1B

6.78e-0520139311742988
Pubmed

Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder.

TMOD2 TMOD1

9.47e-054139215095301
Pubmed

Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes.

ITGB4 SNAI2

9.47e-054139216707493
Pubmed

Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1.

BRIP1 MDC1

9.47e-054139220159462
Pubmed

AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.

DYSF AHNAK2

9.47e-054139217185750
Pubmed

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

TMOD4 TMOD1

9.47e-054139225250574
Pubmed

Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes.

ANK2 SLC8A1

9.47e-054139214593108
Pubmed

Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.

WASHC2C OBSL1 WASHC2A

1.04e-0423139331748650
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

STAM2 RC3H2 OBSL1 SNW1 BAZ1A NUP210 BOD1L1 CDC5L UNC79

1.19e-04469139927634302
Pubmed

Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.

STAM2 TRPM7 TRIP11 SYNE2 CYB5R3 MTDH

1.24e-04191139631177093
Pubmed

The TIP60 Complex Is a Conserved Coactivator of HIF1A.

VWA8 MYO9B LRPPRC NUP210 TBCD

1.25e-04120139527320910
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

NES STAM2 SP100 BRIP1 WASHC2A CEP170 BAZ1A CIAPIN1 BUB1B

1.25e-04472139938943005
Pubmed

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.

BRIP1 MDC1 FAM169A GNL2 MTDH

1.30e-04121139522412018
Pubmed

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.

KIFBP BRPF3 VWA8 CCDC28A TMC6 TMOD2 CARD10 HAUS3 AK3 SLC8A1 MAP4K1 AHNAK2

1.35e-048321391236724073
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

USP14 SNW1 MDC1 GNL2 BOD1L1 TAF1L MTDH

1.50e-04283139730585729
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

MYO9B DNAJC7 CEP170 LRPPRC SNW1 GNL2 PRKCI CDC5L MTDH

1.56e-04486139930940648
Pubmed

LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.

AOPEP SYNE2

1.57e-045139222632968
Pubmed

Mice lacking Tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memory.

TMOD2 TMOD1

1.57e-045139212799133
Pubmed

Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma.

NBPF11 NBPF1

1.57e-045139220096688
Pubmed

Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation.

RIPOR2 DYSF

1.57e-045139224687993
Pubmed

Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte.

TRPM7 TRPM1

1.57e-045139216857711
Pubmed

Involvement of gp130-associated cytokine signaling in Müller cell activation following optic nerve lesion.

LRPPRC IL6ST

1.57e-045139220091786
Pubmed

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain.

ANK2 SLC8A1

1.57e-045139216292983
Pubmed

Gene expression and cell identity controlled by anaphase-promoting complex.

INO80 CDC26 ANAPC2 BUB1B

1.63e-0468139432076268
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

NES DMXL2 TMOD2 CEP170 SNW1 SYNE2 BOD1L1 PEA15 TBCD

1.87e-04498139936634849
Pubmed

ELF a beta-spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/beta-G spectrin gene.

NES ANK2

2.35e-046139212149647
Pubmed

Essential role of alpha 6 integrins in cortical and retinal lamination.

NES ITGB4

2.35e-04613929742403
Pubmed

CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain.

NES PRKCI

2.35e-046139220152182
Pubmed

Ankyrin-B regulates Kir6.2 membrane expression and function in heart.

ANK2 SLC8A1

2.35e-046139220610380
Pubmed

Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice.

DYSF SLC8A1

2.35e-046139224662047
Pubmed

Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation.

ANAPC2 BUB1B

2.35e-046139217443186
Pubmed

Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein.

CEP170 IQCB1

2.35e-046139230584065
Pubmed

Alpha-kinases: a new class of protein kinases with a novel catalytic domain.

TRPM7 ALPK1

2.35e-046139210021370
Pubmed

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

SP100 BRPF3 DNAH7 BAZ1A

2.38e-0475139425593309
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ATMIN RIPOR2 WASHC2C OBSL1 WASHC2A PCDHB16 BOD1L1 ANKRD12

2.44e-04407139812693553
Pubmed

Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.

BRIP1 MDC1 RAD54B

2.59e-0431139319690177
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZGRF1 TTC27 RBBP8NL BCOR SHTN1 ZFHX4 BUB1B CYB5R3

2.91e-04418139834709266
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

DMXL2 OBSL1 SNRK ALPK1 SYNE2 CDC5L

3.01e-04225139612168954
Pubmed

Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20.

CDC26 ANAPC2 BUB1B

3.12e-0433139332152539
Pubmed

Ubiquitin chain elongation requires E3-dependent tracking of the emerging conjugate.

CDC26 ANAPC2 BUB1B

3.12e-0433139325306918
Pubmed

A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia.

CDC26 ANAPC2

3.29e-047139234595750
Pubmed

Exo70, a subunit of the exocyst complex, interacts with SNEV(hPrp19/hPso4) and is involved in pre-mRNA splicing.

SNW1 CDC5L

3.29e-047139221639856
Pubmed

Endolymphatic Na⁺ and K⁺ concentrations during cochlear growth and enlargement in mice lacking Slc26a4/pendrin.

SLC26A4 SCNN1A

3.29e-047139223741519
Pubmed

Different expression patterns of Phactr family members in normal and injured mouse brain.

NES PHACTR1

3.29e-047139222766235
Pubmed

CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†.

TPD52L3 TEX13B TEX13A

3.41e-0434139331201419
Pubmed

The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.

NES STAM2 ABCA4 PBDC1 SHTN1 PEA15 TBCD

3.47e-04325139736168628
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NBPF20 NBPF19 MAP4K1 NBPF9 MDC1 SCN10A NBPF14 SLC35A5

3.52e-04430139835044719
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

KCNH8 DNAH2 CARD10 DNAH7 NBPF19 BANP

3.63e-04233139637704626
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

ZGRF1 BCOR MDC1 CDC5L PLCH1 KIF13A

3.71e-04234139636243803
InteractionBAG2 interactions

RC3H2 BRPF3 CLUAP1 DNAH2 OBSL1 HAUS3 BCOR DNAJC7 CEP170 SNW1 MDC1 IQCB1 BUB1B PRKCI BOD1L1 CDC5L TBCD

1.26e-0662213817int:BAG2
InteractionNAA40 interactions

STAM2 WASHC2C ANK2 BCOR SHTN1 TRIP11 CEP170 USP14 SNW1 BAZ1A CIAPIN1 BUB1B CYB5R3 FAM169A GNL2 TMOD1 BOD1L1 CDC5L MTDH AHNAK2

1.14e-0597813820int:NAA40
Cytoband1q21.1

NBPF8 NBPF11 NBPF9 NBPF10 NBPF14 PEA15

3.70e-086213961q21.1
CytobandEnsembl 112 genes in cytogenetic band chr1q21

NBPF12 TMOD4 NBPF11 NBPF20 NBPF19 NBPF15 NBPF9 NBPF10 NBPF14

4.34e-064041399chr1q21
GeneFamilyNeuroblastoma breakpoint family

NBPF3 NBPF8 NBPF12 NBPF26 NBPF11 NBPF20 NBPF1 NBPF19 NBPF15 NBPF9 NBPF10 NBPF14

4.12e-22239812662
GeneFamilyTropomodulins

TMOD4 TMOD2 TMOD1

6.15e-0749831140
GeneFamilyWASH complex

WASHC2C WASHC2A

4.30e-0469821331
GeneFamilyTransmembrane channel likes

TMC1 TMC6

7.97e-0489821135
GeneFamilyBEN domain containing

BEND6 BANP

1.02e-039982422
GeneFamilyAnaphase promoting complex |Tetratricopeptide repeat domain containing

CDC26 ANAPC2

2.54e-0314982402
GeneFamilyDyneins, axonemal

DNAH2 DNAH7

3.75e-0317982536
GeneFamilyDNA helicases

BRIP1 INO80

3.75e-03179821167
CoexpressionCHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_UP

NES BRIP1 ANK2 ZGRF1 DYSF NUP210 BUB1B PEA15

1.10e-061451398M3045
CoexpressionRIGGINS_TAMOXIFEN_RESISTANCE_DN

CLUAP1 SNRK CARD10 SHTN1 AOPEP SCNN1A RAPGEF2 NBPF14 IL6ST

2.91e-062211399M15835
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

HAUS3 DNAJC7 SHTN1 PPWD1 TRIP11 CEP170 ZNF12 BAZ1A SYNE2 RAD54B BUB1B TRPM1 CDC5L MTDH

1.09e-0565613914M18979
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

RIPOR2 KCNH8 ANK2 TMOD2 GRID2 CHST1 SHTN1 SLC8A1 ZFHX4 FAM169A SORCS3 BOD1L1 ANKRD12 FRMPD3 KIF13A WASF1 UNC79 AHNAK2

2.34e-05110613918M39071
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP

STAM2 DMXL2 RIPOR2 WASHC2C OBSL1 HAUS3 WASHC2A TRIP11 LRPPRC BMPR2 SLF2 BAZ1A SYNE2 NUP210 CIAPIN1 PRKCI RAPGEF2 WASF1 MTDH

2.36e-05121513919M41122
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HOPC

ZGRF1 TMOD2 GRID2 DNAH7 BUB1B TMOD1 SORCS3 NKX2-2 KIF13A PEA15

2.69e-0536613910M39052
CoexpressionONKEN_UVEAL_MELANOMA_UP

ATMIN ANK2 HAUS3 BCOR SHTN1 SNW1 BAZ1A SLC20A1 SYNE2 RAD54B PEA15 MTDH AHNAK2 PHACTR1

8.23e-0579013914M12490
CoexpressionGSE31082_DP_VS_CD4_SP_THYMOCYTE_DN

TMC6 LAD1 SNRK LRPPRC NUP210 GID8 PEA15

9.59e-051991397M5065
CoexpressionGSE8835_HEALTHY_VS_CLL_CD4_TCELL_UP

SLC26A4 BCOR TRIP11 PCDHB16 AOPEP SYNE2 WASF1

9.59e-051991397M6260
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HNBGABA

RIPOR2 ANK2 TMOD2 GRID2 CHST1 SLC8A1 BEND6 ZFHX4 FAM169A SORCS3 ANKRD12 NKX2-2 UNC79

9.80e-0570313913M39070
CoexpressionGSE360_L_MAJOR_VS_B_MALAYI_HIGH_DOSE_MAC_UP

SP100 VWA8 DNAH7 SLC20A1 MDC1 CYB5R3 RAPGEF2

9.89e-052001397M5247
CoexpressionGSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_UP

LAD1 WASHC2A ANKRD12 NKX2-2 PEA15 FMNL1 TBCD

9.89e-052001397M3968
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000

DMXL2 BRIP1 ZGRF1 TTC27 TEX13B SHTN1 RNF17 PCGF6 LRPPRC BAZ1A MDC1 IQCB1 NUP210 RAD54B FAM169A ANKRD12 CFAP61

1.81e-0582013517gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
ToppCellControl-B_intermediate-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RIPOR2 NBPF12 WASHC2C NBPF11 WASHC2A NBPF1 NBPF15 SLF2 NBPF10

7.88e-101441399984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCellControl-B_intermediate-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RIPOR2 NBPF12 WASHC2C NBPF11 WASHC2A NBPF1 NBPF15 SLF2 NBPF10

2.92e-091671399948504367ecf58144d9dd74d2ec531358fc4b309
ToppCellCOVID-19_Mild-CD4+_T_activated|COVID-19_Mild / Disease condition and Cell class

RIPOR2 WASHC2C ALPK1 NBPF11 WASHC2A NBPF1 NBPF15 NBPF10 IL6ST

6.20e-091821399877b6e611626628e709568747512f2827ebb2795
ToppCellMild/Remission-B_naive-1|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RIPOR2 WASHC2C NBPF11 WASHC2A NBPF1 NBPF15 SLF2 NBPF10

1.69e-081431398bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCellControl-B_naive-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RIPOR2 WASHC2C NBPF11 WASHC2A NBPF1 NBPF15 SLF2 NBPF10

6.81e-081711398d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCellLV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

ANK2 TRPM7 VWA8 ECT2L SLC8A1 CFAP61 PDZRN3 PHACTR1

1.53e-071901398de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DMXL2 RIPOR2 MYO9B NBPF26 SLC8A1 SLC20A1 FMNL1 PHACTR1

1.80e-071941398dfe0ece81922bfd7c6673726d3ea2365cbdb5513
ToppCellCOVID-19_Mild-PLT_5|World / Disease Group and Platelet Clusters

KIFBP WASHC2C ZGRF1 DZIP1L SHTN1 WASHC2A SYNE2

5.14e-07152139790ba4e8a735ec8921038fa072129535f0e3fd9ae
ToppCellControl-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RIPOR2 WASHC2C NBPF11 WASHC2A NBPF1 NBPF15 NBPF10

5.86e-0715513970a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCellSevere-B_naive-1|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RIPOR2 WASHC2C WASHC2A NBPF1 NBPF15 SLF2 NBPF10

6.96e-0715913972881b054bbeb479221ee3c38bbd9b0815b123579
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNH8 GRID2 NBPF19 SCN10A NBPF10 PLCH1 NBPF14

1.85e-061841397658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

ANK2 TRPM7 VWA8 SLC8A1 CFAP61 PDZRN3 PHACTR1

2.21e-0618913979c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

ANK2 TRPM7 VWA8 SLC8A1 CFAP61 PDZRN3 PHACTR1

2.21e-0618913975e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

ANK2 TRPM7 VWA8 ECT2L SLC8A1 PDZRN3 PHACTR1

2.37e-06191139725f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

ANK2 TRPM7 VWA8 SLC8A1 AOPEP PDZRN3 PHACTR1

2.45e-061921397ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DMXL2 RIPOR2 WASHC2C SHTN1 DYSF WASHC2A NBPF10

2.45e-061921397b86476037ddf8904c1d8a6b3763af7242c031cf3
ToppCellControl-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

DMXL2 RIPOR2 MYO9B NBPF26 NBPF19 SLC8A1 NBPF14

2.72e-061951397b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

SP100 TRIP11 SYNE2 PRKCI BOD1L1 ANKRD12 AHNAK2

3.10e-06199139718a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCellLPS_IL1RA-Endothelial-Endothelial-Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NES SNRK PCDH12 BMPR2 CYB5R3 KIF13A PEA15

3.21e-0620013977034f57e282982c19c13ee8ab78eabaffa069e30
ToppCellSepsis-Int-URO-Myeloid-tDC|Int-URO / Disease, condition lineage and cell class

OBSL1 AK3 NBPF15 SNW1 BUB1B PEA15 PHACTR1

3.21e-062001397f5d0497a72da21cad24e0ef51c3dc4d024dbf294
ToppCellSevere-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RIPOR2 WASHC2C WASHC2A NBPF1 SLF2 NBPF10

5.21e-061401396683ee5e103f0c68cbbec019249404d381dbc39f3
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CLUAP1 BRIP1 SEPTIN4 PKDCC DNAH7 CFAP61

9.00e-0615413966c1e7682c43c40b58b371c58deb10b839700ebcc
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P3|Hippocampus / BrainAtlas - Mouse McCarroll V32

KCNH8 TMC1 LAD1 TRIM10 NKX2-2

9.32e-06901395a0baaf2b3cf07d457f0d242fc213689cba6fd449
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr|Hippocampus / BrainAtlas - Mouse McCarroll V32

KCNH8 TMC1 LAD1 TRIM10 NKX2-2

9.32e-06901395ab4b08c6ac8695b38f841c0ecf2bb2c032111d04
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DMXL2 SHTN1 BEND6 BAZ1A BUB1B CFAP61

1.20e-051621396d712bc31840ad1523e3dbf884acbb428a8995001
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMOD4 ECT2L RNF17 RAD54B TMOD1 PLCH1

1.43e-051671396d78356bf0c473816dbabaee51984940bd822f84e
ToppCelldroplet-Heart-HEART-1m-Hematologic-red_blood_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC27 HAUS3 ZBTB42 TRIM10 RAPGEF2

1.63e-0510113956c4524be89cf3eb06769c2963dcded3da1e71ca0
ToppCellCOVID-19_Severe-Classical_Monocyte-cMono_1|Classical_Monocyte / Disease condition and Cell class

RIPOR2 WASHC2C SHTN1 WASHC2A NBPF1 NBPF10

1.86e-05175139635ea2ed93538e6bf803029fcf7d9243f93e7733d
ToppCell390C-Endothelial_cells-Endothelial-E-|390C / Donor, Lineage, Cell class and subclass (all cells)

NES ZGRF1 CARD10 DYSF BMPR2 UNC79

2.05e-051781396804ac3725c1f88e2212172bfb9aa01d97a735621
ToppCell390C-Endothelial_cells-Endothelial-E|390C / Donor, Lineage, Cell class and subclass (all cells)

NES ZGRF1 CARD10 DYSF BMPR2 UNC79

2.05e-051781396ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCellE17.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SEPTIN4 CHST1 PCDH12 DYSF CYB5R3 PEA15

2.05e-051781396982205ba117a4c7b7e9b713689a5b69190f0bca9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 ZGRF1 TRIM10 NUP210 RAD54B BUB1B

2.11e-05179139680112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCellLV|World / Chamber and Cluster_Paper

TRPM7 VWA8 ECT2L CFAP61 PDZRN3 PHACTR1

2.18e-0518013965ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)-|367C / Donor, Lineage, Cell class and subclass (all cells)

ABCA4 SLC26A4 CARD10 DYSF ITGB4 TMOD1

2.25e-051811396b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCellCOVID-19_Severe-Classical_Monocyte-cMono_1|COVID-19_Severe / Disease condition and Cell class

RIPOR2 WASHC2C SHTN1 WASHC2A NBPF1 NBPF10

2.25e-0518113960d07a67e8ee3bca687b378afbc4044434e63556d
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)|367C / Donor, Lineage, Cell class and subclass (all cells)

ABCA4 SLC26A4 CARD10 DYSF ITGB4 TMOD1

2.25e-051811396dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIFBP SEPTIN4 TMOD2 ERMN TMOD1 NKX2-2

2.25e-05181139604c278ad22e32a4f75af92fc9bfe439363c04f90
ToppCellNS-critical-d_07-13-Lymphoid-NK|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NES SEPTIN4 SNAI2 TMOD1 TRPM1 PDZRN3

2.32e-051821396dd1c59babf7211362452e3e264009d70004d99f6
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam____kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC26A4 HMX3 SLC8A1 SCNN1A CFAP61 PHACTR1

2.32e-051821396fe4fb213dc0ca482b0f94097fe1b0a51fc2690e2
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 BRIP1 ZGRF1 BEND6 RAD54B BUB1B

2.47e-05184139616aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DMXL2 BRIP1 ZGRF1 BEND6 RAD54B BUB1B

2.54e-051851396b4af9ae4c358b48357cb135b740266e1652d886a
ToppCellLV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

ANK2 TRPM7 VWA8 SLC8A1 PDZRN3 PHACTR1

2.54e-0518513966baccb26f999145e51b91d94315bf8d4655bef31
ToppCellRV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

TRPM7 VWA8 ECT2L CFAP61 PDZRN3 PHACTR1

2.70e-05187139678cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

TRPM7 SLC20A1 SYNE2 ANKRD12 RAPGEF2 IL6ST

2.78e-051881396ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNH8 TMC6 ERMN ZFHX4 NKX2-2 KIF13A

2.78e-051881396d9692b6048d9b85524a07a1807bdd4757731c151
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC26A4 HMX3 SLC8A1 SCNN1A CFAP61 PHACTR1

2.78e-051881396315ce1736e3a84a63a8d5dfa70d411b501cb2532
ToppCellHippocampus-Neuronal-Excitatory|Hippocampus / BrainAtlas - Mouse McCarroll V32

RC3H2 SLC26A4 CHST1 WASF1 FMNL1 PHACTR1

2.87e-0518913964b90d181eb0a42814eeb23bc82e52fd3a12392a7
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

ANK2 SLC8A1 AOPEP CFAP61 PDZRN3 PHACTR1

2.87e-0518913960a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellwk_20-22-Endothelial-Lymph_endothelial-Intermediate_lymphatic_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ABCA4 SLC26A4 CARD10 DYSF ITGB4 TMOD1

2.95e-051901396103e78c2233c3ee0c215a9dafe70705477e9ee5e
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

ANK2 TRPM7 VWA8 SLC8A1 PDZRN3 PHACTR1

2.95e-051901396fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellMyeloid-Myeloid-B_(Activated_Macrophage)|Myeloid / shred on cell class and cell subclass (v4)

DMXL2 SHTN1 BAZ1A BUB1B CYB5R3 AHNAK2

3.04e-0519113967bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NES SEPTIN4 TMOD2 CHST1 PCDH12 BMPR2

3.04e-051911396718330bb97fe8a1ffd0c82e9af23311a32eacfe1
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NES SEPTIN4 TMOD2 CHST1 PCDH12 BMPR2

3.04e-051911396454034ad940377ee079afa8ce33f8e0bdeaf44f8
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DMXL2 RIPOR2 WASHC2C SHTN1 DYSF NBPF10

3.04e-051911396c9f3bdb5c0a90268cab24a0fe4c3a8290fcedeb8
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KCNH8 ANK2 SHTN1 DNAH7 SCNN1A PLCH1

3.13e-051921396b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH7 AOPEP SYNE2 SCNN1A PRKCI PHACTR1

3.22e-051931396f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH7 AOPEP SYNE2 SCNN1A PRKCI PHACTR1

3.22e-05193139642df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DMXL2 RIPOR2 WASHC2C SHTN1 DYSF NBPF10

3.22e-0519313964fb020f11fd7aff06952bfeaabc79b2c7b8873f6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH7 AOPEP SYNE2 PRKCI PLCH1 PHACTR1

3.32e-051941396e577d9e88390b36b5a09b97fe1026089892275a3
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 BRIP1 SHTN1 BEND6 RAD54B BUB1B

3.32e-051941396effd38e51062b225ecabc7e1c50154e65495d559
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DMXL2 RIPOR2 WASHC2C SHTN1 DYSF NBPF10

3.32e-051941396885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCellControl-Myeloid-ncMonocyte|Control / Disease state, Lineage and Cell class

RIPOR2 MYO9B NBPF26 NBPF19 SLC8A1 NBPF14

3.42e-051951396fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NES PCDH12 DYSF BMPR2 SNAI2 IL6ST

3.52e-051961396d323f7dc41380446e5967c69832bea88351a9331
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NBPF26 RNF17 BAZ1A SYNE2 ANKRD12 FRMPD3

3.52e-051961396ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|lung / Disease (COVID-19 only), tissue and cell type

DMXL2 RIPOR2 MYO9B DYSF SLC8A1 FMNL1

3.62e-051971396a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_3|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

RIPOR2 KCNH8 SHTN1 PCDHB16 ANKRD12 PDZRN3

3.62e-051971396d77bc37a77546a1f0a508486a38a45e571e4645b
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

DMXL2 RIPOR2 MYO9B DYSF SLC8A1 FMNL1

3.72e-051981396ea34096bee852a7e996f097fa279381afa8f86ff
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

TRIP11 CEP170 BAZ1A SYNE2 BOD1L1 ANKRD12

3.72e-05198139676d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NES PCDH12 DYSF BMPR2 SNAI2 IL6ST

3.83e-0519913968b62d43af8b2ebb4c1b2d068d50beaf35728dbe7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NES PCDH12 DYSF BMPR2 SNAI2 IL6ST

3.83e-051991396da5a88749d859d535daa030d0974485906cc0ba7
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M|organoid_Kanton_Nature / Sample Type, Dataset, Time_group, and Cell type.

TMOD2 SHTN1 CEP170 BOD1L1 ANKRD12 PDZRN3

3.83e-051991396b2d7dea11207cca63d688f8051143850b29dbdf0
ToppCellNeuron|World / Primary Cells by Cluster

ANK2 TMOD2 SHTN1 CEP170 ANKRD12 WASF1

3.83e-0519913961f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCell(05)_Secretory-(2)_GFP_FOXI1|(05)_Secretory / shred by cell type by condition

TRIP11 BAZ1A SYNE2 BOD1L1 ANKRD12 MTDH

3.83e-051991396d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCellNeuron-Postmitotic|World / Primary Cells by Cluster

ANK2 TMOD2 SHTN1 CEP170 ANKRD12 WASF1

3.83e-0519913961973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

NES SNRK PCDH12 BMPR2 CYB5R3 PEA15

3.93e-052001396bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NES PCDH12 DYSF BMPR2 SNAI2 IL6ST

3.93e-052001396b1be27d134a8633e3e7862c6a0d7be2001d387f0
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NES SNRK PCDH12 BMPR2 SYNE2 PEA15

3.93e-05200139679e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Alv_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

NES SNRK PCDH12 BMPR2 CYB5R3 PEA15

3.93e-05200139666f7e8ee63c828f17468e79a4b816346b33e8980
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

ANK2 TMOD2 SHTN1 CEP170 SLC8A1 WASF1

3.93e-052001396db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NES SNRK PCDH12 BMPR2 CYB5R3 PEA15

3.93e-052001396b7533c571eeea0cb3678e1a57d3dc036fa8d0f49
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

ANK2 TMOD2 SHTN1 CEP170 SLC8A1 WASF1

3.93e-05200139630a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NES PCDH12 DYSF BMPR2 SNAI2 IL6ST

3.93e-052001396ced14d83222dbebca85c40540e76824e683354f3
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

SLC26A4 ZNF189 CHST1 ZFHX4 WASF1

8.93e-051441395e2a2f260f5ebaaef46248d199c407a15ce9d024a
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

CLUAP1 BRIP1 PKDCC DNAH7 CFAP61

1.15e-0415213957a1072315cce71eefe2d32149a107d5648999968
ToppCelldroplet-Liver-LIVER-NPC-1m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 TRIM10 MAP4K1 TMOD1 FMNL1

1.19e-041531395a8f83ec640fae51d4fba34b92e3d6cca4999e930
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PPWD1 IQCB1 NUP210 TMOD1 TBCD

1.51e-041611395d72c572613f8eff3251cb7b1e9dcc76d193b2f21
ToppCelldroplet-Liver-LIVER-NPC-1m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 TRIM10 MAP4K1 RAD54B FMNL1

1.60e-04163139566ecd544d7b52e61880b125bf39d1f406af6900a
ToppCellfacs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF17 DYSF TRIM10 BEND6 TMOD1

1.69e-0416513954f95c2fe5ab4416c736fe0d1936695a2b26777eb
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_1|COVID-19_Mild / Disease condition and Cell class

RIPOR2 WASHC2C NBPF11 SHTN1 WASHC2A

1.69e-041651395ef709c5d3231c65d351316e1e31b9c9eba721628
ToppCellfacs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF17 DYSF TRIM10 BEND6 TMOD1

1.69e-0416513953e913b49a868fdd5589200ae3e9be77c0938ba14
ToppCellEndothelial-B-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

ABCA4 ANK2 CARD10 PCDH12 ZFHX4

1.74e-041661395c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCellBasal_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

CARD10 ITGB4 AOPEP SNAI2 AHNAK2

1.74e-041661395aea2ae12e4746149ebc6da063ef694381c098f80
ToppCellEndothelial-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

ABCA4 CARD10 PCDH12 ZFHX4 TMOD1

1.79e-0416713956a03d16165e0b003092c39972928981abd4a75aa
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Il33_(Il33)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SEPTIN4 ERMN TMOD1 TRPM1

1.81e-04901394091bbcceecb7b5c30b92e0c991bb117561b43b89
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Il33_(Il33)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SEPTIN4 ERMN TMOD1 TRPM1

1.81e-049013945046bb6a66ce138c5c1dc4060d1360d494a91a67
ToppCellCOVID-19-Heart-Neuronal|COVID-19 / Disease (COVID-19 only), tissue and cell type

KCNH8 ANK2 TMOD2 ITGB4 SORCS3

1.84e-04168139588c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_1|Classical_Monocyte / Disease condition and Cell class

RIPOR2 WASHC2C NBPF11 WASHC2A SYNE2

1.84e-041681395d50078614f7af74dc2aa4081c1708a5156ac51cf
ToppCelldroplet-Kidney-nan-21m-Lymphocytic-CD45____B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 RIPOR2 DNAJC7 BAZ1A MAP4K1

1.89e-041691395d44fc49056799dfc70a3c7d538c210d88ffded05
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMOD4 RNF17 SORCS3 PLCH1 UNC79

1.89e-04169139512bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DMXL2 SHTN1 BAZ1A MAP4K1 FMNL1

2.10e-041731395279efbab7810fa60ab12ea5d09a84800df4adef0
ComputationalBreast cancer expression clusters.

NBPF3 AK3 NUP210 BOD1L1 TRPM1 KIF13A

8.59e-0598806MODULE_480
ComputationalGenes in the cancer module 427.

NBPF3 AK3 NUP210 BOD1L1 TRPM1 KIF13A

2.18e-04116806MODULE_427
DrugPesticides

NBPF8 NBPF12 NBPF11 NBPF20 NBPF1 NBPF15 NBPF9 NBPF10 NBPF14

3.02e-071501369ctd:D010575
DrugThulium bromide

TMOD4 TMOD2 TMOD1

4.12e-0661363CID000084454
DiseaseSensorineural Hearing Loss (disorder)

DMXL2 RIPOR2 TMC1 SLC26A4

2.55e-06231254C0018784
Diseasesinoatrial node disease (implicated_via_orthology)

ANK2 TRPM7

1.78e-0521252DOID:0050824 (implicated_via_orthology)
Diseaseocular hypertension, response to triamcinolone acetonide

BRIP1 VWA8 ITGB4 CFAP61

5.61e-05491254EFO_0006954, EFO_1001069
DiseaseMicrocephaly

KIFBP PCDH12 BUB1B TBCD

1.91e-04671254C0025958
DiseaseSevere Congenital Microcephaly

KIFBP BUB1B TBCD

3.06e-04311253C3853041
DiseaseMASA syndrome (implicated_via_orthology)

TRPM7 TRPM1

3.69e-0471252DOID:0060246 (implicated_via_orthology)
DiseaseMicrolissencephaly

KIFBP BUB1B TBCD

3.69e-04331253C1956147
DiseaseEmbryonal Rhabdomyosarcoma

BCOR BUB1B

4.90e-0481252C0206656
Diseaseprimary immunodeficiency disease (is_implicated_in)

CARD10 IRAK4 IL6ST

7.55e-04421253DOID:612 (is_implicated_in)
Diseasebrain ischemia (biomarker_via_orthology)

NES SLC8A1 IRAK4 IL6ST

9.47e-041021254DOID:2316 (biomarker_via_orthology)
DiseaseCleft palate, cleft lip

ABCA4 SHTN1 RAD54B TMOD1 NKX2-2 MTDH

1.24e-032791256EFO_0003959, HP_0000175
DiseaseMalformations of Cortical Development

KIFBP TBCD

1.57e-03141252C1955869
DiseaseCortical Dysplasia

KIFBP TBCD

1.57e-03141252C0431380
DiseaseQRS duration

OBSL1 CHST1 SLC8A1 AOPEP SCN10A PDZRN3

1.73e-032981256EFO_0005055
Diseasevascular endothelial growth factor measurement

VWA8 DNAH2 CDC5L

1.75e-03561253EFO_0004762
Diseasecolorectal cancer (is_implicated_in)

BRIP1 BCOR RAD54B BUB1B

1.78e-031211254DOID:9256 (is_implicated_in)
DiseaseGerm Cell Cancer

BUB1B SCNN1A

1.80e-03151252C0740345
DiseaseEmbryonal Neoplasm

BUB1B SCNN1A

1.80e-03151252C0027654
DiseaseNeoplasms, Germ Cell and Embryonal

BUB1B SCNN1A

1.80e-03151252C0027658
DiseaseGerm cell tumor

BUB1B SCNN1A

1.80e-03151252C0205851
DiseaseNeoplasms, Embryonal and Mixed

BUB1B SCNN1A

1.80e-03151252C0205852
DiseaseCancer, Embryonal

BUB1B SCNN1A

1.80e-03151252C0751364
DiseaseCancer, Embryonal and Mixed

BUB1B SCNN1A

1.80e-03151252C0751365
DiseaseQT interval

BRIP1 TRPM7 ZBTB42 SLC8A1 AOPEP SCN10A PDZRN3 PHACTR1

2.02e-035341258EFO_0004682
DiseaseRomano-Ward Syndrome

ANK2 SCN10A

2.05e-03161252C0035828
Diseasebreast carcinoma (is_marker_for)

BRIP1 SNW1 MDC1

2.80e-03661253DOID:3459 (is_marker_for)
DiseaseHereditary hearing loss and deafness

RIPOR2 TMC1 SLC26A4 LRPPRC

3.51e-031461254cv:C0236038
Diseaselung cancer

BRIP1 PKDCC

3.55e-03211252MONDO_0008903
DiseaseNonsyndromic genetic hearing loss

RIPOR2 TMC1 SLC26A4

4.17e-03761253cv:C5680182

Protein segments in the cluster

PeptideGeneStartEntry
VTDEDEPALKRQRLE

BANP

31

Q8N9N5
ERLLPEEDLDVKTSE

BUB1B

636

O60566
DDIESKLRAESEVPI

CEP170

1451

Q5SW79
EKEPDNVDLVSELRA

CARD10

271

Q9BWT7
ILASKEEEDLPSIEQ

CFAP61

1166

Q8NHU2
EIVLPENAEKELEER

CDC5L

491

Q99459
DEKLEVPEDIRAALE

ANAPC2

606

Q9UJX6
ERALEKTEPLTEETE

ABCA4

891

P78363
DLIDSDELLDPEDLK

CIAPIN1

211

Q6FI81
DPLKIITEDELTAQD

BRPF3

56

Q9ULD4
TLNEPKTEDEELLER

ECT2L

166

Q008S8
LENIPEEKRLELSVE

AOPEP

631

Q8N6M6
ALDTLLEQTPKEDDE

DMXL2

1811

Q8TDJ6
PTRLELKLDDIEEFE

CDC26

6

Q8NHZ8
AETEELELLLKREVP

ANKRD12

291

Q6UB98
VDLLREEPDAKTDTN

BCOR

806

Q6W2J9
SEDEEPLAELSKEEL

BEND6

56

Q5SZJ8
TREPLTADEEEALKQ

BAZ1A

766

Q9NRL2
LLLEAPDVSEEDKSE

ALPK1

21

Q96QP1
EDATDTKPDRDIELE

RC3H2

1046

Q9HBD1
IILSREPSASEEEKE

RAD54B

496

Q9Y620
SDPESVDKELELLNE

PDZRN3

676

Q9UPQ7
QTEKDILLRPELEEL

CYB5R3

211

P00387
PKEVVSLLLDDEELE

INO80

1261

Q9ULG1
PEEDLSVKQLLEEEL

PCDH12

1021

Q9NPG4
SDEEIEEARQKAPLE

ANK2

1596

Q01484
RKPQLSEDESDLEIS

DZIP1L

711

Q8IYY4
EEVVESPALLLQKED

OBSL1

936

O75147
EDSPLELKIQALDSE

NUP210

131

Q8TEM1
PASKDEDEDIQSILR

LAD1

76

O00515
VQLTPDDDDIVRKID

PRKCI

561

P41743
PEEQRKTLEEDVDDR

GNL2

636

Q13823
LERETEKLLPERQTD

MDC1

831

Q14676
ELDSKSPDEIILEES

HMX3

166

A6NHT5
DDLTGEPLIQREDDK

AK3

151

Q9UIJ7
ELEELPEDKRKTASD

CCDC28A

226

Q8IWP9
EEKLQELESVSRDPS

DDX58

591

O95786
SRVPSKEDDKEIDLE

GRID2

861

O43424
TLRIDVLDPEELKSE

PBDC1

81

Q9BVG4
EEDELDTKLTRIPSA

PEA15

91

Q15121
PRSLEEDLETLKSLE

NES

576

P48681
SVLELIPELNEKEEA

LRPPRC

1306

P42704
KERITEQPLKEEEDE

ERMN

131

Q8TAM6
RPEDDDEKQLLVEAI

ITGB4

951

P16144
SRELLDEKEPEVLQD

NBPF1

966

Q3BBV0
ELEEKNILPRQTDEE

PHACTR1

436

Q9C0D0
PDIELSLVSEEDKQS

BRIP1

1101

Q9BX63
LDKELDREEEPQLRL

PCDHB16

196

Q9NRJ7
RELLDEKEPEVLQDS

NBPF3

406

Q9H094
SKAEVLRPESDELDE

RBBP8NL

561

Q8NC74
KEENSRDLEELPKTS

BOD1L1

2811

Q8NFC6
DTQELEASEIKLEPS

ATMIN

256

O43313
LLDSEERPEDLQLVD

IL6ST

786

P40189
EEQVSELRDNLPKEV

FRMPD3

956

Q5JV73
LSLEAEKTREPEVEL

C3orf20

871

Q8ND61
NDELLEILSETKDPT

DNAH7

1076

Q8WXX0
EPSVDLETLDERIKI

GID8

56

Q9NWU2
LQLTEEDLETNKLDP

BMPR2

656

Q13873
TPRLDDKELEKLEDE

HAUS3

91

Q68CZ6
DSTSEVLDEELKLQP

FAM169A

446

Q9Y6X4
DTEELEKEIREDLPV

MTDH

461

Q86UE4
DSDQDREERKLLLDP

LAMTOR1

11

Q6IAA8
TRPSALELKVEELEE

FMNL1

471

O95466
PELLDDQEAKREAET

DNAJC7

16

Q99615
IDVPKDELSIELENL

IQCB1

576

Q15051
EISPDLQISIKDEEL

FAM180A

66

Q6UWF9
REPQLLLDIKEEIED

IRAK4

391

Q9NWZ3
ERPELEEQKDSLVIN

DNAH2

3526

Q9P225
PEIKEELEELDRITE

SCNN1A

141

P37088
ERLPSVDLKEETSID

SLC20A1

331

Q8WUM9
DPSEDKEDIESNLLR

DYSF

356

O75923
RFLPEEEKLTEQERS

KIFBP

186

Q96EK5
EDEEERLINLSELTP

PCGF6

116

Q9BYE7
IPKATEEIEDRETLA

KIF13A

1311

Q9H1H9
EPDDDVSTLQKEILI

MAP4K1

51

Q92918
VALTLDLDLEKEPES

SLC29A2

256

Q14542
LKVTDLDDARVEETP

PKDCC

291

Q504Y2
DPETEKLIREKDEEL

SEPTIN4

446

O43236
EIEEEDKLLPTEDQS

SYNE2

2031

Q8WXH0
IQKSEPLDAVLIEDE

SYNE2

6311

Q8WXH0
RELLDEKEPEVLQDS

NBPF8

661

Q3BBV2
RELLDEKEPEVLQDS

NBPF9

696

P0DPF3
ELLDEKEPEVLQDSL

NBPF9

866

P0DPF3
RELLDEKEPEVLQDS

NBPF10

696

Q6P3W6
ELLDEKEPEVLQDSL

NBPF10

941

Q6P3W6
LLDEKEPEVLQDSLD

NBPF10

1186

Q6P3W6
LSRELLDEKEPEVLQ

NBPF10

1426

Q6P3W6
LDEKEPEVLQDSLDR

NBPF10

1431

Q6P3W6
SRELLDEKEPEVLQD

NBPF10

1671

Q6P3W6
RELLDEKEPEVLQDS

NBPF10

1916

Q6P3W6
ELLDEKEPEVLQDSL

NBPF10

2161

Q6P3W6
LLDEKEPEVLQDSLD

NBPF10

2406

Q6P3W6
LSRELLDEKEPEVLQ

NBPF10

2646

Q6P3W6
LDEKEPEVLQDSLDR

NBPF10

2651

Q6P3W6
SRELLDEKEPEVLQD

NBPF10

2891

Q6P3W6
RELLDEKEPEVLQDS

NBPF10

3136

Q6P3W6
ELLDEKEPEVLQDSL

NBPF10

3381

Q6P3W6
LLDEKEPEVLQDSLD

NBPF10

3626

Q6P3W6
RELLDEKEPEVLQDS

NBPF11

621

Q86T75
RELLAEKEPEVLQDS

NBPF11

696

Q86T75
SRELLAEKEPEVLQD

NBPF12

891

Q5TAG4
SRELLAEKEPEVLQD

NBPF12

966

Q5TAG4
RELLAEKEPEVLQDS

NBPF12

1136

Q5TAG4
RELLAEKEPEVLQDS

NBPF12

1211

Q5TAG4
RELLDEKEPEVLQDS

NBPF14

356

Q5TI25
ELLDEKEPEVLQESL

NBPF14

601

Q5TI25
ELLDEKEPEVLQDSL

NBPF14

676

Q5TI25
ELLDEKEPEVLQDSL

NBPF15

351

Q8N660
ELLDEKEPEVLQDSL

NBPF15

426

Q8N660
ELLDEKEPEVLQDSL

NBPF19

426

A0A087WUL8
LLDEKEPEVLQDSLD

NBPF19

671

A0A087WUL8
LSRELLDEKEPEVLQ

NBPF19

911

A0A087WUL8
LDEKEPEVLQDSLDR

NBPF19

916

A0A087WUL8
SRELLDEKEPEVLQD

NBPF19

1156

A0A087WUL8
RELLDEKEPEVLQDS

NBPF19

1401

A0A087WUL8
ELLDEKEPEVLQDSL

NBPF19

1646

A0A087WUL8
LLDEKEPEVLQDSLD

NBPF19

1891

A0A087WUL8
LSRELLDEKEPEVLQ

NBPF19

2131

A0A087WUL8
LDEKEPEVLQDSLDR

NBPF19

2136

A0A087WUL8
SRELLDEKEPEVLQD

NBPF19

2376

A0A087WUL8
RELLDEKEPEVLQDS

NBPF19

2621

A0A087WUL8
ELLDEKEPEVLQDSL

NBPF19

2866

A0A087WUL8
SRELLAEKEPEVLQD

NBPF19

3596

A0A087WUL8
RELLDEKEPEVLQDS

NBPF20

81

P0DPF2
ELLDEKEPEVLQDSL

NBPF20

326

P0DPF2
LLDEKEPEVLQDSLD

NBPF20

571

P0DPF2
LSRELLDEKEPEVLQ

NBPF20

811

P0DPF2
LDEKEPEVLQDSLDR

NBPF20

816

P0DPF2
SRELLDEKEPEVLQD

NBPF20

1056

P0DPF2
RELLDEKEPEVLQDS

NBPF20

1301

P0DPF2
ELLDEKEPEVLQDSL

NBPF20

1546

P0DPF2
LLDEKEPEVLQDSLD

NBPF20

1791

P0DPF2
LSRELLDEKEPEVLQ

NBPF20

2031

P0DPF2
LDEKEPEVLQDSLDR

NBPF20

2036

P0DPF2
SRELLDEKEPEVLQD

NBPF20

2276

P0DPF2
RELLDEKEPEVLQDS

NBPF20

2521

P0DPF2
ELLDEKEPEVLQDSL

NBPF20

2766

P0DPF2
LLDEKEPEVLQDSLD

NBPF20

3011

P0DPF2
LSRELLDEKEPEVLQ

NBPF20

3251

P0DPF2
LDEKEPEVLQDSLDR

NBPF20

3256

P0DPF2
SRELLDEKEPEVLQD

NBPF20

3496

P0DPF2
RELLDEKEPEVLQDS

NBPF20

3741

P0DPF2
ELLDEKEPEVLQDSL

NBPF20

3986

P0DPF2
LLDEKEPEVLQDSLD

NBPF20

4231

P0DPF2
LSRELLDEKEPEVLQ

NBPF20

4396

P0DPF2
LDEKEPEVLQDSLDR

NBPF20

4401

P0DPF2
SRELLDEKEPEVLQD

NBPF20

4566

P0DPF2
SRELLDEKEPEVLQD

NBPF20

4716

P0DPF2
RELLDEKEPEVLQDS

NBPF20

4961

P0DPF2
RELLDEKEPEVLQDS

NBPF26

656

B4DH59
TEPEELLDKELDTRV

SORCS3

1186

Q9UPU3
ENLILEIPDEKEEAT

TAF1L

526

Q8IZX4
DEIAPLKESTDLLDI

NEXMIF

1041

Q5QGS0
EPEKTELSERELAVA

PPWD1

21

Q96BP3
ISDEEERLQSKLSDP

SNAI2

106

O43623
KSLDPENSETELERI

SHTN1

466

A0MZ66
SVKDILDLPDTNDEE

NKX2-2

11

O95096
VLRLEDISKEPSDET

SLF2

386

Q8IX21
KIDVPQDLEDDLTAT

SNRK

366

Q9NRH2
LLQESEEASELKPVE

RIPOR2

541

Q9Y4F9
SSEEEEEVEDKLPRR

TMC1

21

Q8TDI8
ELILPEQDRKADDES

AHNAK2

5771

Q8IVF2
EEELKNPSVSLVEER

CHST1

391

O43916
DDESDSELEERRLPK

CLUAP1

321

Q96AJ1
SLSEKSLEVPLEQED

RNF17

1116

Q9BXT8
LEKDPIDRTDDDIEQ

RAPGEF2

111

Q9Y4G8
VSLDVLNRDKDEEPT

ZNF189

51

O75820
PVLKDDNESEISELE

ZFHX4

106

Q86UP3
PTLEKDLNVDREENT

ZSCAN5DP

216

P0CG00
IEDLEELDIPTKEIE

SLC26A4

621

O43511
EELERLTKPKSDESD

SLC35A5

406

Q9BS91
ELRTLENELDELDPD

TMOD1

26

P28289
EILRKIPELADDLEE

SCN10A

1096

Q9Y5Y9
KLPLQESEEEEREER

SP100

151

P23497
DSKPDSQDLLDLEDI

STAM2

311

O75886
KKERRTPSDDEEDNL

WASHC2C

326

Q9Y4E1
DLQRPDEEAIKEITE

SNW1

131

Q13573
EDEILRTLSPEELEQ

TMOD4

16

Q9NZQ9
ESLLKESQIRDKEDP

PLCH1

496

Q4KWH8
EEVEEETDPRKIELL

TRPM1

441

Q7Z4N2
PLVKDERDSLSEQEE

ZBTB42

221

B2RXF5
KKERRTPSDDEEDNL

WASHC2A

326

Q641Q2
EAELPDSRTKEIEAI

TRIP11

46

Q15643
IEELEEKNERPAREL

TRIM10

236

Q9UDY6
VEDKLRAILEDSEVP

TEX13A

46

Q9BXU3
LKEDEVELSEPLQSV

ZGRF1

891

Q86YA3
QSEQKPLILTEDDDE

TBCD

336

Q9BTW9
DPTALEEEEKQSLLV

TMC6

136

Q7Z403
DDLIERIQEEENKPS

ZNF12

86

P17014
TQLDPKEEELSLQDI

WASF1

81

Q92558
LEDLTEPEQRELKTK

TPD52L3

21

Q96J77
EEILRQELEKKETPS

TTC27

486

Q6P3X3
DDDKVSIVTPEDILR

USP14

451

P54578
TIEINTDDNLEPELK

VWA8

706

A3KMH1
ETRKEEKVTLDPELE

TMOD2

106

Q9NZR1
KRTKDEIVDIDDPET

TRPM7

601

Q96QT4
VEDKLRAILEDSEVP

TEX13B

46

Q9BXU2
ETLDPKEALSELERV

THEG

76

Q9P2T0
ELERVLDKDLEEDIP

THEG

86

Q9P2T0
LDKDLEEDIPEISRL

THEG

91

Q9P2T0
KEESRLVEPTDSLED

UNC79

881

Q9P2D8
NINKRLPSIVEDEEE

KCNH8

701

Q96L42
QPLTSKEEEERRIAE

SLC8A1

686

P32418
PKTRDIQEEELEVLL

MYO9B

1936

Q13459