Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	TSSK2 NEK3 PRKG1 HK2 GRK2 GRK3 EPHA6 NEK5 MAP3K5	8.68e-06	709	40	9	GO:0016773
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	1.17e-05	3	40	2	GO:0018858
GeneOntologyMolecularFunction	kinase activity	TSSK2 NEK3 PRKG1 HK2 GRK2 GRK3 EPHA6 NEK5 MAP3K5	1.58e-05	764	40	9	GO:0016301
GeneOntologyMolecularFunction	protein kinase activity	TSSK2 NEK3 PRKG1 GRK2 GRK3 EPHA6 NEK5 MAP3K5	2.09e-05	600	40	8	GO:0004672
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM2A ACSM2B	2.34e-05	4	40	2	GO:0102391
GeneOntologyMolecularFunction	beta-adrenergic receptor kinase activity	GRK2 GRK3	2.34e-05	4	40	2	GO:0047696
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	TSSK2 NEK3 PRKG1 GRK2 GRK3 NEK5 MAP3K5	2.61e-05	446	40	7	GO:0004674
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	TSSK2 NEK3 PRKG1 HK2 GRK2 GRK3 EPHA6 NEK5 MAP3K5	7.86e-05	938	40	9	GO:0016772
GeneOntologyMolecularFunction	G protein-coupled receptor kinase activity	GRK2 GRK3	8.16e-05	7	40	2	GO:0004703
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM2A ACSM2B	1.09e-04	8	40	2	GO:0004321
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSM2A ACSM2B	2.13e-04	11	40	2	GO:0031956
GeneOntologyMolecularFunction	mRNA regulatory element binding translation repressor activity	CPEB2 CPEB4	5.22e-04	17	40	2	GO:0000900
GeneOntologyMolecularFunction	protein serine kinase activity	TSSK2 NEK3 PRKG1 NEK5 MAP3K5	7.53e-04	363	40	5	GO:0106310
GeneOntologyMolecularFunction	C-acyltransferase activity	ACSM2A ACSM2B	8.02e-04	21	40	2	GO:0016408
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSM2A ACSM2B	1.23e-03	26	40	2	GO:0015645
GeneOntologyMolecularFunction	CoA-ligase activity	ACSM2A ACSM2B	1.33e-03	27	40	2	GO:0016405
GeneOntologyMolecularFunction	acid-thiol ligase activity	ACSM2A ACSM2B	1.75e-03	31	40	2	GO:0016878
GeneOntologyMolecularFunction	ligase activity, forming carbon-sulfur bonds	ACSM2A ACSM2B	3.05e-03	41	40	2	GO:0016877
GeneOntologyMolecularFunction	ligase activity	NADSYN1 ACSM2A ACSM2B	5.07e-03	174	40	3	GO:0016874
GeneOntologyMolecularFunction	tumor necrosis factor receptor superfamily binding	CASP3 TRAF3	5.63e-03	56	40	2	GO:0032813
Domain	Protein_kinase_ATP_BS	TSSK2 NEK3 PRKG1 GRK2 GRK3 EPHA6 NEK5 MAP3K5	1.16e-06	379	40	8	IPR017441
Domain	PROTEIN_KINASE_ATP	TSSK2 NEK3 PRKG1 GRK2 GRK3 EPHA6 NEK5 MAP3K5	4.82e-06	459	40	8	PS00107
Domain	Prot_kinase_dom	TSSK2 NEK3 PRKG1 GRK2 GRK3 EPHA6 NEK5 MAP3K5	7.67e-06	489	40	8	IPR000719
Domain	PROTEIN_KINASE_DOM	TSSK2 NEK3 PRKG1 GRK2 GRK3 EPHA6 NEK5 MAP3K5	8.14e-06	493	40	8	PS50011
Domain	Ser/Thr_kinase_AS	TSSK2 NEK3 PRKG1 GRK2 GRK3 NEK5 MAP3K5	9.52e-06	357	40	7	IPR008271
Domain	S_TKc	TSSK2 NEK3 PRKG1 GRK2 GRK3 NEK5 MAP3K5	9.87e-06	359	40	7	SM00220
Domain	PROTEIN_KINASE_ST	TSSK2 NEK3 PRKG1 GRK2 GRK3 NEK5 MAP3K5	1.04e-05	362	40	7	PS00108
Domain	Pkinase	TSSK2 NEK3 PRKG1 GRK2 GRK3 NEK5 MAP3K5	1.45e-05	381	40	7	PF00069
Domain	Kinase-like_dom	TSSK2 NEK3 PRKG1 GRK2 GRK3 EPHA6 NEK5 MAP3K5	1.62e-05	542	40	8	IPR011009
Domain	CEBP_ZZ	CPEB2 CPEB4	2.68e-05	4	40	2	IPR032296
Domain	CEBP_ZZ	CPEB2 CPEB4	2.68e-05	4	40	2	PF16366
Domain	RRM_7	CPEB2 CPEB4	2.68e-05	4	40	2	PF16367
Domain	GPCR_kinase	GRK2 GRK3	9.33e-05	7	40	2	IPR000239
Domain	AGC-kinase_C	PRKG1 GRK2 GRK3	2.33e-04	56	40	3	IPR000961
Domain	AGC_KINASE_CTER	PRKG1 GRK2 GRK3	2.33e-04	56	40	3	PS51285
Domain	S_TK_X	PRKG1 GRK2 GRK3	2.33e-04	56	40	3	SM00133
Domain	AMP-bd_C	ACSM2A ACSM2B	5.96e-04	17	40	2	IPR025110
Domain	AMP-binding_C	ACSM2A ACSM2B	5.96e-04	17	40	2	PF13193
Domain	AMP-binding_CS	ACSM2A ACSM2B	1.41e-03	26	40	2	IPR020845
Domain	AMP_BINDING	ACSM2A ACSM2B	1.63e-03	28	40	2	PS00455
Domain	AMP-binding	ACSM2A ACSM2B	1.87e-03	30	40	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSM2A ACSM2B	1.87e-03	30	40	2	IPR000873
Domain	RGS	GRK2 GRK3	2.54e-03	35	40	2	PF00615
Domain	RGS	GRK2 GRK3	2.54e-03	35	40	2	SM00315
Domain	RGS	GRK2 GRK3	2.69e-03	36	40	2	PS50132
Domain	RGS	GRK2 GRK3	3.15e-03	39	40	2	IPR016137
Domain	Ser-Thr/Tyr_kinase_cat_dom	NEK3 EPHA6 NEK5	3.19e-03	138	40	3	IPR001245
Domain	RRM_1	CPEB2 MTHFSD CPEB4	9.94e-03	208	40	3	PF00076
Domain	RRM	CPEB2 MTHFSD CPEB4	1.11e-02	217	40	3	SM00360
Domain	RRM_dom	CPEB2 MTHFSD CPEB4	1.26e-02	227	40	3	IPR000504
Pathway	REACTOME_CONJUGATION_OF_SALICYLATE_WITH_GLYCINE	ACSM2A ACSM2B	8.93e-05	6	35	2	MM14693
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM2A ACSM2B	1.25e-04	7	35	2	MM14598
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM2A ACSM2B	2.13e-04	9	35	2	M26968
Pubmed	Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.	CPEB2 CASP3 CPEB4	1.14e-06	18	40	3	30111840
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	1.29e-06	2	40	2	16521160
Pubmed	Cloning of GRK2 cDNA from S49 murine lymphoma cells.	GRK2 GRK3	1.29e-06	2	40	2	8638670
Pubmed	Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.	GRK2 GRK3	1.29e-06	2	40	2	33060647
Pubmed	G protein--coupled receptor kinases.	GRK2 GRK3	1.29e-06	2	40	2	8035170
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	1.29e-06	2	40	2	19634011
Pubmed	Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.	GRK2 GRK3	1.29e-06	2	40	2	10198406
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	1.29e-06	2	40	2	29948332
Pubmed	G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.	GRK2 GRK3	1.29e-06	2	40	2	11762794
Pubmed	Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells.	CASP3 TRAF3	1.29e-06	2	40	2	11261798
Pubmed	Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.	GRK2 GRK3	3.87e-06	3	40	2	10754297
Pubmed	Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.	GRK2 GRK3	3.87e-06	3	40	2	10085131
Pubmed	Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.	GRK2 GRK3	3.87e-06	3	40	2	7761854
Pubmed	CPEB2, a novel putative translational regulator in mouse haploid germ cells.	CPEB2 CPEB4	3.87e-06	3	40	2	12672660
Pubmed	The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.	GRK2 GRK3	3.87e-06	3	40	2	31604529
Pubmed	S-nitrosation of thioredoxin in the nitrogen monoxide/superoxide system activates apoptosis signal-regulating kinase 1.	CASP3 MAP3K5	3.87e-06	3	40	2	15246877
Pubmed	Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk.	GRK2 GRK3	3.87e-06	3	40	2	12130708
Pubmed	Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis.	CASP3 MAP3K5	3.87e-06	3	40	2	15670787
Pubmed	Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity.	CASP3 NEK5	3.87e-06	3	40	2	23727203
Pubmed	Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle.	CPEB2 CPEB4	3.87e-06	3	40	2	26398195
Pubmed	CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue.	CPEB2 CPEB4	7.73e-06	4	40	2	30177570
Pubmed	Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.	CPEB2 CPEB4	7.73e-06	4	40	2	12871996
Pubmed	Expression of the NEK family in normal and cancer tissue: an immunohistochemical study.	NEK3 NEK5	7.73e-06	4	40	2	31906878
Pubmed	Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.	GRK2 GRK3	7.73e-06	4	40	2	21784156
Pubmed	Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.	GRK2 GRK3	7.73e-06	4	40	2	8917529
Pubmed	Quercetin ameliorates ischemia/reperfusion-induced cognitive deficits by inhibiting ASK1/JNK3/caspase-3 by enhancing the Akt signaling pathway.	CASP3 MAP3K5	7.73e-06	4	40	2	27450812
Pubmed	Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.	GRK2 GRK3	7.73e-06	4	40	2	8662816
Pubmed	Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.	ACSM2A ACSM2B	7.73e-06	4	40	2	32830538
Pubmed	Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.	GRK2 GRK3	7.73e-06	4	40	2	23734232
Pubmed	A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons.	CPEB2 CPEB4	1.29e-05	5	40	2	20639532
Pubmed	Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.	GRK2 GRK3	1.29e-05	5	40	2	10338466
Pubmed	Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1).	TRAF3 MAP3K5	1.29e-05	5	40	2	10523862
Pubmed	Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2.	CASP3 GRK2	1.29e-05	5	40	2	24135140
Pubmed	beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.	GRK2 GRK3	1.93e-05	6	40	2	9826657
Pubmed	Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2.	GRK2 GRK3	1.93e-05	6	40	2	20074556
Pubmed	Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.	GRK2 GRK3	1.93e-05	6	40	2	36451830
Pubmed	TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis.	CASP3 TRAF3	2.70e-05	7	40	2	11098060
Pubmed	Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.	GRK2 GRK3	2.70e-05	7	40	2	8672451
Pubmed	Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.	GRK2 GRK3	2.70e-05	7	40	2	11517230
Pubmed	ASK1 is essential for JNK/SAPK activation by TRAF2.	TRAF3 MAP3K5	3.60e-05	8	40	2	9774977
Pubmed	Def-2, -3, -6 and -8, novel mouse genes differentially expressed in the haemopoietic system.	HK2 TEX2	3.60e-05	8	40	2	10460589
Pubmed	Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.	CASP3 CTLA4	4.62e-05	9	40	2	15917267
Pubmed	ARRB1 ameliorates liver ischaemia/reperfusion injury via antagonizing TRAF6-mediated Lysine 6-linked polyubiquitination of ASK1 in hepatocytes.	TRAF3 MAP3K5	4.62e-05	9	40	2	32445435
Pubmed	Molecular determinants of response kinetics of mouse M1 intrinsically-photosensitive retinal ganglion cells.	GRK2 GRK3	4.62e-05	9	40	2	34873237
Pubmed	Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions.	CASP3 EXOC5	4.62e-05	9	40	2	26046524
Pubmed	Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein.	CASP3 GRK2	4.62e-05	9	40	2	23729591
Pubmed	Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family.	GRK2 GRK3	5.77e-05	10	40	2	1869533
Pubmed	The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.	CASP3 TRAF3	5.77e-05	10	40	2	9384571
Pubmed	Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction.	CPEB2 CPEB4	5.77e-05	10	40	2	27810937
Pubmed	Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways.	CASP3 MAP3K5	7.05e-05	11	40	2	17015619
Pubmed	Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development.	CASP3 MAP3K5	9.98e-05	13	40	2	23319608
Pubmed	Fibroproliferative response to urothelial failure obliterates the ureter lumen in a mouse model of prenatal congenital obstructive nephropathy.	CASP3 EXOC5	1.73e-04	17	40	2	27511831
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	CPEB2 EXOC5 AP1B1 DDX6 CPEB4	1.82e-04	462	40	5	31138677
Pubmed	Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.	CASP3 MAP3K5	1.95e-04	18	40	2	23982205
Pubmed	The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice.	CASP3 CDX4	2.18e-04	19	40	2	16396910
Pubmed	Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells.	CASP3 DDX6	2.42e-04	20	40	2	25416063
Pubmed	β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation.	CASP3 CDX4	2.67e-04	21	40	2	24284205
Pubmed	Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions.	CASP3 EPHA6	3.21e-04	23	40	2	25480914
Pubmed	Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination.	CASP3 TRAF3	3.50e-04	24	40	2	27709293
Pubmed	Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.	ACSM2A ACSM2B	3.80e-04	25	40	2	19372376
Pubmed	Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.	CASP3 KMT2B	3.80e-04	25	40	2	25664857
Pubmed	HIV-1 mediated immune pathogenesis: spotlight on the role of viral protein R (Vpr).	CASP3 CTLA4	3.80e-04	25	40	2	19275586
Pubmed	ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development.	CASP3 MAP3K5	4.78e-04	28	40	2	26173459
Pubmed	Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome.	CASP3 HK2	4.78e-04	28	40	2	32369449
Pubmed	Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.	CASP3 EPHA6	5.13e-04	29	40	2	20615956
Pubmed	T-Cell Signaling in HIV-1 Infection.	CTLA4 MAP3K5	6.26e-04	32	40	2	23986795
Pubmed	The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse.	CASP3 MTHFSD	6.26e-04	32	40	2	23369715
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	EXOC5 NEK5 DDX6	7.18e-04	152	40	3	34299191
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	CASP3 TRAF3 CTLA4 MAP3K5	8.60e-04	371	40	4	25241761
Pubmed	mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia.	CASP3 HK2	9.79e-04	40	40	2	34677125
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	NEK3 HK2 AQR DDX6	1.14e-03	400	40	4	35013556
Interaction	ACSM2A interactions	ACSM2A ACSM2B	2.18e-05	4	39	2	int:ACSM2A
Interaction	ACSM2B interactions	ACSM2A ACSM2B	2.18e-05	4	39	2	int:ACSM2B
Cytoband	16p12.3	ACSM2A ACSM2B	4.08e-04	34	40	2	16p12.3
GeneFamily	Acyl-CoA synthetase family	ACSM2A ACSM2B	6.83e-04	26	27	2	40
Coexpression	GSE17721_CTRL_VS_PAM3CSK4_12H_BMDC_DN	HK2 GRK2 EPHA6 ECE2 MAP3K5	1.27e-05	199	40	5	M3750
Coexpression	GSE11961_MEMORY_BCELL_DAY7_VS_MEMORY_BCELL_DAY40_UP	TSSK2 CASP3 CTLA4 AP1B1 SLC22A15	1.27e-05	199	40	5	M9369
Coexpression	RUTELLA_RESPONSE_TO_HGF_UP	TBC1D16 CASP3 TRAF3 HK2 GRK3 TEX2	4.01e-05	421	40	6	M18149
CoexpressionAtlas	kidney_adult_Podocyte_MafB_k-means-cluster#2_top-relative-expression-ranked_200	PRKG1 SLCO2A1 CPEB4	7.45e-06	21	39	3	gudmap_kidney_adult_Podocyte_MafB_k2_200
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_Captopr_top-relative-expression-ranked_1000	PRKG1 FAHD1 ACSM2A TEX2 SLCO2A1 MAP3K5 CPEB4 KCNJ16	7.03e-05	778	39	8	gudmap_kidney_adult_JuxtaGlom_Ren1_Captopr_1000
CoexpressionAtlas	kidney_adult_Mesangium_Meis_k-means-cluster#1_top-relative-expression-ranked_500	SLCO2A1 MAP3K5 CPEB4	7.71e-05	45	39	3	gudmap_kidney_adult_Mesangium_Meis_k1_500
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRAF3 GRK3 EPHA6 FBXW12 TEX2 TRPM2	6.39e-09	160	40	6	5d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HK2 GRK3 TRPM2 KCNJ16	1.18e-05	157	40	4	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF3 HK2 GRK3 MAP3K5	1.27e-05	160	40	4	2020b6defbaf5b5db12af37f0103ac028a8ca76e
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF3 HK2 GRK3 MAP3K5	1.27e-05	160	40	4	af7cf0dc5fe7c02f7d6c436f6dde766c79ff0eae
ToppCell	droplet-Liver-Npc-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HK2 GRK2 TRPM2 KCNJ16	1.81e-05	175	40	4	1973fff0d7e1a94b31f461a39b91cc7984ebd8f1
ToppCell	droplet-Liver-Npc-18m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HK2 GRK2 TRPM2 KCNJ16	1.81e-05	175	40	4	92a4a3fd323ee8360edd659f9e16dfddc8788e2f
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	KCNIP4 ACSM2A ACSM2B KCNJ16	1.85e-05	176	40	4	36f77d878a53b30465b0dea8333a3865dba75613
ToppCell	droplet-Liver-Npc-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HK2 GRK2 TRPM2 KCNJ16	1.85e-05	176	40	4	1e430dffddd315d9a1cb4bd7fef5077656351c65
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KCNIP4 ACSM2A ACSM2B KCNJ16	2.11e-05	182	40	4	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KCNIP4 ACSM2A ACSM2B KCNJ16	2.16e-05	183	40	4	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KCNIP4 ACSM2A ACSM2B KCNJ16	2.35e-05	187	40	4	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	COVID-19-kidney-DCT\|kidney / Disease (COVID-19 only), tissue and cell type	KCNIP4 CPEB4 SLC22A15 KCNJ16	2.40e-05	188	40	4	df1fd0819d301679f3c9ea404e942e39095912eb
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNIP4 CPEB4 SLC22A15 KCNJ16	2.45e-05	189	40	4	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CPEB2 CPEB4 SLC22A15 KCNJ16	2.45e-05	189	40	4	977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNIP4 CPEB4 SLC22A15 KCNJ16	2.45e-05	189	40	4	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CPEB2 KCNIP4 TRAF3 KCNJ16	2.55e-05	191	40	4	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CPEB2 KCNIP4 TRAF3 KCNJ16	2.55e-05	191	40	4	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	KCNIP4 PRKG1 ACSM2A ACSM2B	2.60e-05	192	40	4	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	TBC1D16 GRK3 TEX2 SLC22A15	2.66e-05	193	40	4	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACSM2A CPEB4 ACSM2B KCNJ16	2.66e-05	193	40	4	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KCNIP4 ACSM2A ACSM2B KCNJ16	2.71e-05	194	40	4	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-LTK--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	EPHA6 SLCO2A1 ECE2 MAP3K5	3.05e-05	200	40	4	66e2f3e2e9063f17b47621120eb6009405f69e7e
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-LTK---L2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	EPHA6 SLCO2A1 ECE2 MAP3K5	3.05e-05	200	40	4	6ebdae4438bc64c6620416f64a7e22fbca2664bf
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-LTK\|Neuronal / cells hierarchy compared to all cells using T-Statistic	EPHA6 SLCO2A1 ECE2 MAP3K5	3.05e-05	200	40	4	940892bea41fde567f138a896d151acccef03a6a
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-LTK-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	EPHA6 SLCO2A1 ECE2 MAP3K5	3.05e-05	200	40	4	081ca331b56f85167acfc73af9d2e91f398f8c4d
ToppCell	COVID-19_Mild-dn_T\|COVID-19_Mild / Disease condition and Cell class	CTLA4 GRK2 GRK3	1.54e-04	116	40	3	79c918f3bebfd5e0b865d2c7673af9ee3bc48779
Drug	tempol	CASP3 HK2 GRK2 GRK3 AP1B1 MAP3K5	2.28e-06	221	40	6	CID000137994
Drug	HMS3267E16	CASP3 GRK2 GRK3 SLCO2A1	4.23e-06	62	40	4	CID000003668
Drug	8-CPT-cAMP	CASP3 PRKG1 GRK2 GRK3 MAP3K5	5.20e-06	144	40	5	CID000001903
Drug	AMP group	NADSYN1 PRKG1 HK2 GRK2 GRK3 ACSM2A TRPM2 ACSM2B	6.25e-06	579	40	8	CID000000224
Drug	Sp-8-Cl-cAMPS	PRKG1 GRK2 GRK3	7.56e-06	22	40	3	CID000133987
Drug	glutamin	CASP3 NADSYN1 GRK2 ACSM2A DDX6 MAP3K5 ACSM2B	1.39e-05	461	40	7	CID000000738
Drug	AC1NUTWC	ACSM2A ACSM2B	1.80e-05	4	40	2	CID005460914
Drug	KT5720	CASP3 PRKG1 GRK2 GRK3 MAP3K5	1.94e-05	189	40	5	CID000003844
Drug	Go6976	CASP3 PRKG1 GRK2 GRK3 MAP3K5	1.99e-05	190	40	5	CID000003501
Drug	Cefotaxime sodium salt [64485-93-4]; Up 200; 8.4uM; MCF7; HT_HG-U133A	CASP3 EXOC5 TRAF3 TAF13 SLCO2A1	2.31e-05	196	40	5	7186_UP
Drug	C070379	CASP3 PRKG1 HK2 GRK2 GRK3	2.49e-05	199	40	5	CID003034747
Drug	AC1L1E8W	CASP3 GRK2 GRK3 SLCO2A1	3.70e-05	107	40	4	CID000002691
Drug	Nitroprusside	CASP3 PRKG1 GRK3 MAP3K5	4.27e-05	111	40	4	ctd:D009599
Drug	PTIO	CASP3 PRKG1 MAP3K5	4.39e-05	39	40	3	CID002733513
Drug	betaARKct	GRK2 GRK3	4.49e-05	6	40	2	CID000002295
Drug	S-nitrosocysteine	CASP3 GRK2	4.49e-05	6	40	2	ctd:C021315
Drug	Isosorbide Dinitrate	CASP3 PRKG1	4.49e-05	6	40	2	ctd:D007548
Drug	8-chloroadenosine	CASP3 GRK2 GRK3	4.74e-05	40	40	3	CID000147569
Drug	AC1L1GTT	CASP3 PRKG1 GRK2 GRK3 MAP3K5	5.28e-05	233	40	5	CID000003837
Drug	8-phenyl-6a,7,8,9,9a,10-hexahydro-6H-isoindolo(5,6-g)quinoxaline-7,9-dione	CASP3 MAP3K5	6.28e-05	7	40	2	ctd:C556801
Drug	AH6809	GRK2 GRK3 SLCO2A1	6.77e-05	45	40	3	CID000119461
Drug	Rp-8-Br-cGMPS	PRKG1 GRK2 GRK3	7.24e-05	46	40	3	CID003035839
Drug	Desipramine	CASP3 GRK2 GRK3	7.72e-05	47	40	3	ctd:D003891
Drug	Ammonia	CASP3 NADSYN1 PRKG1	8.22e-05	48	40	3	ctd:D000641
Drug	S-nitroso-N-acetyl-D,L-penicillamine	CASP3 PRKG1 GRK2 GRK3	8.89e-05	134	40	4	CID000005231
Drug	triethylamine	PRKG1 GRK2 GRK3	9.30e-05	50	40	3	CID000008471
Drug	2,3-DPG	PRKG1 HK2 GRK2 GRK3	9.69e-05	137	40	4	CID000000061
Drug	Monensin	CASP3 TRPM2	1.08e-04	9	40	2	ctd:D008985
Drug	SCT-1	GRK2 GRK3	1.08e-04	9	40	2	CID000211458
Drug	Ptpc	CASP3 HK2 MAP3K5	1.24e-04	55	40	3	CID003036276
Drug	8-Br	CASP3 PRKG1 GRK2 GRK3	1.60e-04	156	40	4	CID000168120
Drug	S-nitrosopenicillamine	CASP3 PRKG1	1.64e-04	11	40	2	CID000126366
Drug	dihydrochloride	CASP3 PRKG1 GRK2 GRK3	1.72e-04	159	40	4	CID000070978
Drug	AC1L1GU8	PRKG1 GRK2 GRK3	1.77e-04	62	40	3	CID000003843
Drug	Clotrimazole	CASP3 HK2 TRPM2	2.13e-04	66	40	3	ctd:D003022
Drug	F2-b	PRKG1 GRK2 GRK3	2.13e-04	66	40	3	CID000001700
Drug	MDL-12330A	TRAF3 GRK2 GRK3	2.13e-04	66	40	3	CID000004024
Drug	ciglitazone	CASP3 HK2 SLCO2A1 MAP3K5	2.17e-04	169	40	4	CID000002750
Drug	8-pCPT-cGMP	PRKG1 GRK2 GRK3	2.23e-04	67	40	3	CID000123969
Drug	Chromium Compounds	CASP3 MAP3K5	2.32e-04	13	40	2	ctd:D017608
Drug	geranyl nitrile	GRK2 GRK3	2.32e-04	13	40	2	CID000021768
Drug	salicyluric acid	ACSM2A ACSM2B	2.32e-04	13	40	2	CID000010253
Drug	AC1L19C4	HK2 GRK2 GRK3	2.43e-04	69	40	3	CID000000483
Drug	BAPTA	CASP3 PRKG1 GRK2 GRK3 TRPM2	2.47e-04	324	40	5	CID000104751
Drug	phenylisopropyladenosine	GRK2 GRK3 SLCO2A1	2.53e-04	70	40	3	CID000005022
Drug	tempol	CASP3 TRAF3 PRKG1	2.64e-04	71	40	3	ctd:C001803
Drug	8-N3cAMP	GRK2 GRK3	2.70e-04	14	40	2	CID006426627
Drug	8-(6-aminohexyl)amino cyclic AMP	GRK2 GRK3	2.70e-04	14	40	2	CID000161999
Drug	(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride	CASP3 PRKG1	2.70e-04	14	40	2	ctd:C439285
Drug	obtusilactone A	CASP3 MAP3K5	2.70e-04	14	40	2	CID006442492
Drug	OD-q	CASP3 PRKG1 GRK2 GRK3	2.71e-04	179	40	4	CID000001456
Disease	X-21319 measurement	ACSM2A ACSM2B	1.70e-06	2	39	2	EFO_0800807
Disease	X-11478 measurement	ACSM2A ACSM2B	5.10e-06	3	39	2	EFO_0021242
Disease	hypertension (biomarker_via_orthology)	CASP3 PRKG1 HK2 GRK2 GRK3	1.20e-05	227	39	5	DOID:10763 (biomarker_via_orthology)
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	1.70e-05	5	39	2	EFO_0800378
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	2.54e-05	6	39	2	EFO_0800106
Disease	hyperglycemia (implicated_via_orthology)	HK2 GRK2	2.29e-04	17	39	2	DOID:4195 (implicated_via_orthology)
Disease	brain age measurement	PRKG1 ECE2	3.19e-04	20	39	2	EFO_0010602
Disease	impotence (biomarker_via_orthology)	CASP3 PRKG1	3.87e-04	22	39	2	DOID:1875 (biomarker_via_orthology)
Disease	Sezary Syndrome	CTLA4 PRKG1	5.85e-04	27	39	2	C0036920
Disease	Parkinson's disease (biomarker_via_orthology)	GRK2 GRK3	7.23e-04	30	39	2	DOID:14330 (biomarker_via_orthology)
Disease	primary biliary cirrhosis	CTLA4 NADSYN1 DDX6	7.27e-04	133	39	3	EFO_1001486

Protein segments in the cluster

Peptide	Gene	Start	Entry
YCLKRELLMGIFEMG	DDX6	101	P26196
EDYALGKDCIMHGYM	GRK3	551	P35626
MYGSCLLEKEAGMYP	CDX4	1	O14627
MKIKPGYMGTAASCY	ACSM2A	376	Q08AH3
FMYMCLLGYPADKIS	AQR	1211	O60306
FMEMLSKDLDYYGTL	AP1B1	266	Q10567
SYKMDYPEMGLCIII	CASP3	36	P42574
EDYALGKDCIMHGYM	GRK2	551	P25098
LACGEKGGYKIMMYF	OR9G1	186	Q8NH87
DYGMGLELGMDLFCY	HPF1	286	Q9NWY4
SKYLYMLMEACLGGE	PRKG1	431	Q13976
CIADFLEYMGMKGVS	HK2	581	P52789
TAYLDYMEELGMLLG	ECE2	321	P0DPD6
YCMEAYLTKDGPFLM	FBXW12	191	Q6X9E4
LFIVMEYCDGGDLMK	NEK5	76	Q6P3R8
KAIYDMMGKCTYPVL	KCNIP4	186	Q6PIL6
MDYVGGYALCLDMTA	FAHD1	91	Q6P587
YDGKGIGCYMFRMDD	KMT2B	2621	Q9UMN6
MLDVGPYMKALEYAC	LHPP	166	Q9H008
YIVMEYCDGGDLMQK	NEK3	76	P51956
MGGMLAICDVAEYRK	EXOC5	626	O00471
LAMIMDRLYGGVCYA	CPEB2	456	Q7Z5Q1
CDEMDAGGLGKMIFY	CHAMP1	41	Q96JM3
AMDTGLYICKVELMY	CTLA4	121	P16410
LAMIMDRLYGGVCYA	CPEB4	596	Q17RY0
GEMGIYQMYLCFLLA	SLC22A15	11	Q8IZD6
GIASGMKYLSDMGYV	EPHA6	781	Q9UF33
ASDMYCLVGRIYKDM	MAP3K5	386	Q99683
LFSKELRCMMYGFGD	TAF13	31	Q15543
MKIKPGYMGTAASCY	ACSM2B	376	Q68CK6
MGYKALGMLLLCFIS	SLCO2A1	611	Q92959
GYKMCARVYLNGDGM	TRAF3	451	Q13114
NLLKCGMEVYKGYMD	TRPM2	1416	O94759
GYLCLYMEKDEMLGA	TBC1D16	61	Q8TBP0
YFALIGMRDGKLCLM	KCNJ16	186	Q9NPI9
IGKGEGYADLEYAMM	MTHFSD	151	Q2M296
KMLLDYSVYMGRCVP	TEX2	771	Q8IWB9
LYIMVCGSMPYDDSD	TSSK2	206	Q96PF2
MLLLGSMYGYDKKGN	LIPK	11	Q5VXJ0
DGDRLYYDGCAMIAM	NADSYN1	236	Q6IA69