Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionWnt receptor activity

FZD1 FZD7 FZD8 FZD2

4.06e-06171324GO:0042813
GeneOntologyMolecularFunctionlipid antigen binding

PSAP CD1B CD1C

5.57e-0661323GO:0030882
GeneOntologyMolecularFunctionPDZ domain binding

FZD1 FZD7 FZD8 CLCN3 FZD2 ATP2B2 SNTB1

1.77e-051231327GO:0030165
GeneOntologyMolecularFunctionWnt-protein binding

FZD1 FZD7 FZD8 FZD2

7.25e-05341324GO:0017147
GeneOntologyMolecularFunctionintegrin binding

FN1 ACTN4 ACTN1 ADAM8 ITGB5 SVEP1 CD40LG

1.65e-041751327GO:0005178
GeneOntologyMolecularFunctioncell adhesion molecule binding

FN1 LILRB2 ACTN4 ACTN1 ADAM8 ITGB5 SVEP1 PTPRD PTPRF SND1 CD40LG SNX9 GCN1

1.72e-0459913213GO:0050839
GeneOntologyMolecularFunctionstalled ribosome sensor activity

MAP3K20 GCN1

2.58e-0441322GO:0170011
GeneOntologyMolecularFunctionexogenous lipid antigen binding

CD1B CD1C

4.28e-0451322GO:0030884
GeneOntologyMolecularFunctionendogenous lipid antigen binding

CD1B CD1C

4.28e-0451322GO:0030883
GeneOntologyMolecularFunctionopsonin binding

CFHR1 CFHR5 MASP2

5.84e-04251323GO:0001846
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

ACTN4 ACTN1 HELZ2 MED12

7.11e-04611324GO:0030374
GeneOntologyBiologicalProcessnegative regulation of cell adhesion

EPHB2 TNFAIP8L2 METTL3 PDE3B LILRB2 ACTN4 APOD SIPA1 ADAM8 TNFRSF21 FZD7 ADAMTS18 TMEM131L

9.63e-0737513313GO:0007162
GeneOntologyBiologicalProcesscell-cell adhesion

MAGI1 TNFAIP8L2 METTL3 CARMIL2 LILRB2 ACTN1 CLSTN1 ADAM8 TNFRSF21 ITGB5 SVEP1 SCARF1 PTPRD PTPRF CSK PTPRS LPP CD40LG PCDHGB4 ADAMTS18 TMEM131L COL14A1

1.47e-06107713322GO:0098609
GeneOntologyBiologicalProcessregulation of immune response

EPHB2 CFHR1 METTL3 CARMIL2 LILRB2 GPX1 TLR7 CFHR5 ADAM8 TNFRSF21 SVEP1 CD1B CD1C LIMK1 POLR3B PTPRD CSK PTPRS TRIM56 CD40LG MASP2 SPINK5

1.66e-06108513322GO:0050776
GeneOntologyBiologicalProcesspositive regulation of cell projection organization

EPHB2 CARMIL2 FN1 KALRN NTRK3 TIAM2 FZD1 SCARF1 PLEK2 LIMK1 PTPRD PTPRF MEGF8 RRN3

3.86e-0649413314GO:0031346
GeneOntologyBiologicalProcessregulation of cell adhesion

EPHB2 MAGI1 TNFAIP8L2 METTL3 PDE3B CARMIL2 FN1 LILRB2 ACTN4 APOD SIPA1 ADAM8 TNFRSF21 FZD7 CSK CD40LG ADAMTS18 TMEM131L SPINK5

7.91e-0692713319GO:0030155
GeneOntologyBiologicalProcesscell junction organization

EPHB2 FN1 KALRN LILRB2 NTRK3 ADGRB2 ACTN4 ACTN1 APOD CLSTN1 SVEP1 SEMA4C FZD1 PTPRD PTPRF CSK PTPRS ABCC8 ATP2B2

1.58e-0597413319GO:0034330
GeneOntologyBiologicalProcessresponse to wounding

EPHB2 CARMIL2 FN1 NTRK3 GPX1 ACTN1 APOD ITGB5 SVEP1 SCARF1 FZD7 PTPRF PTPRS CD40LG ADAMTS18

2.34e-0565913315GO:0009611
GeneOntologyBiologicalProcessregulation of cell development

EPHB2 METTL3 CARMIL2 FN1 KALRN LILRB2 NTRK3 ADAM8 TIAM2 LIMK1 PTPRD PTPRF CSF3R MEGF8 PTPRS ABCC8 CD40LG TMEM131L ASXL2 SPINK5

2.39e-05109513320GO:0060284
GeneOntologyBiologicalProcessregulation of synapse organization

EPHB2 KALRN LILRB2 NTRK3 ADGRB2 CLSTN1 SEMA4C FZD1 PTPRD PTPRF PTPRS

4.30e-0538713311GO:0050807
GeneOntologyBiologicalProcesspositive regulation of cell development

EPHB2 CARMIL2 FN1 KALRN LILRB2 NTRK3 ADAM8 TIAM2 LIMK1 PTPRD PTPRF MEGF8 CD40LG ASXL2

4.37e-0561413314GO:0010720
GeneOntologyBiologicalProcessregulation of synapse assembly

EPHB2 NTRK3 ADGRB2 CLSTN1 SEMA4C FZD1 PTPRD PTPRS

5.07e-052021338GO:0051963
GeneOntologyBiologicalProcessregulation of synapse structure or activity

EPHB2 KALRN LILRB2 NTRK3 ADGRB2 CLSTN1 SEMA4C FZD1 PTPRD PTPRF PTPRS

5.17e-0539513311GO:0050803
GeneOntologyBiologicalProcessregulation of nervous system development

EPHB2 FN1 KALRN NTRK3 ADGRB2 CLSTN1 TNFRSF21 TIAM2 LIMK1 PTPRD PTPRF MEGF8 PTPRS ABCC8

5.29e-0562513314GO:0051960
GeneOntologyBiologicalProcesspositive regulation of cellular component organization

EPHB2 NCAPD3 CARMIL2 FN1 KALRN ABCA13 NTRK3 GPX1 ADGRB2 ACTN4 CLSTN1 TIAM2 FZD1 SCARF1 PLEK2 LIMK1 PTPRD PTPRF MEGF8 RRN3 ABCC8 SNX9

6.06e-05136613322GO:0051130
GeneOntologyBiologicalProcessaxon regeneration

NTRK3 APOD SCARF1 PTPRF PTPRS

8.35e-05691335GO:0031103
GeneOntologyBiologicalProcesspositive regulation of nervous system development

EPHB2 FN1 KALRN NTRK3 ADGRB2 CLSTN1 TIAM2 LIMK1 PTPRD PTPRF MEGF8

8.57e-0541813311GO:0051962
GeneOntologyBiologicalProcesspositive regulation of immune response

CFHR1 CARMIL2 TLR7 CFHR5 ADAM8 TNFRSF21 SVEP1 CD1B CD1C LIMK1 POLR3B CSK PTPRS TRIM56 CD40LG MASP2

1.11e-0484513316GO:0050778
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

EPHB2 CARMIL2 FN1 KALRN NTRK3 TIAM2 FZD1 SCARF1 PLEK2 LIMK1 LIMK2 PTPRD PTPRF MEGF8 PTPRS RRN3

1.12e-0484613316GO:0120035
GeneOntologyBiologicalProcessprotein-RNA covalent cross-linking repair

RNF25 GCN1

1.23e-0431332GO:0160127
GeneOntologyBiologicalProcessregulation of axon regeneration

NTRK3 SCARF1 PTPRF PTPRS

1.26e-04401334GO:0048679
GeneOntologyBiologicalProcessnon-canonical Wnt signaling pathway

FZD1 FZD7 FZD8 FZD2 MED12

1.41e-04771335GO:0035567
GeneOntologyBiologicalProcessregulation of cell projection organization

EPHB2 CARMIL2 FN1 KALRN NTRK3 TIAM2 FZD1 SCARF1 PLEK2 LIMK1 LIMK2 PTPRD PTPRF MEGF8 PTPRS RRN3

1.41e-0486313316GO:0031344
GeneOntologyBiologicalProcessregulation of neuron projection development

EPHB2 FN1 KALRN NTRK3 TIAM2 FZD1 SCARF1 LIMK1 PTPRD PTPRF MEGF8 PTPRS RRN3

1.67e-0461213313GO:0010975
GeneOntologyBiologicalProcessT cell activation

TNFAIP8L2 METTL3 PSAP CARMIL2 LILRB2 ADAM8 TNFRSF21 FZD7 FZD8 CD1C CSK CD40LG TMEM131L SPINK5

1.77e-0470113314GO:0042110
GeneOntologyBiologicalProcessneuron projection regeneration

NTRK3 APOD SCARF1 PTPRF PTPRS

1.79e-04811335GO:0031102
GeneOntologyBiologicalProcessregulation of cell junction assembly

EPHB2 NTRK3 ADGRB2 APOD CLSTN1 SEMA4C FZD1 PTPRD PTPRS

1.82e-043091339GO:1901888
GeneOntologyBiologicalProcesspostsynapse organization

EPHB2 KALRN LILRB2 NTRK3 ACTN1 SEMA4C PTPRD PTPRF PTPRS

2.00e-043131339GO:0099173
GeneOntologyBiologicalProcessregulation of postsynapse organization

EPHB2 KALRN LILRB2 SEMA4C PTPRD PTPRF PTPRS

2.00e-041851337GO:0099175
GeneOntologyBiologicalProcessregeneration

NTRK3 GPX1 APOD SCARF1 FZD7 PTPN12 PTPRF PTPRS

2.34e-042521338GO:0031099
GeneOntologyBiologicalProcesspositive regulation of synapse assembly

EPHB2 NTRK3 ADGRB2 CLSTN1 PTPRD

2.37e-04861335GO:0051965
GeneOntologyBiologicalProcessregulation of neuron projection regeneration

NTRK3 SCARF1 PTPRF PTPRS

2.38e-04471334GO:0070570
GeneOntologyBiologicalProcessGCN2-mediated signaling

MAP3K20 GCN1

2.46e-0441332GO:0140469
GeneOntologyBiologicalProcessregulation of axonogenesis

EPHB2 FN1 NTRK3 TIAM2 LIMK1 MEGF8 PTPRS

2.52e-041921337GO:0050770
GeneOntologyBiologicalProcessaxon development

EPHB2 FN1 KALRN NTRK3 APOD TNFRSF21 TIAM2 SEMA4C SCARF1 LIMK1 PTPRF MEGF8 PTPRS

2.66e-0464213313GO:0061564
GeneOntologyBiologicalProcesscell junction assembly

EPHB2 FN1 NTRK3 ADGRB2 ACTN4 ACTN1 APOD CLSTN1 SEMA4C FZD1 PTPRD PTPRS

3.21e-0456913312GO:0034329
GeneOntologyBiologicalProcesspostsynapse assembly

EPHB2 NTRK3 SEMA4C PTPRD PTPRS

3.41e-04931335GO:0099068
GeneOntologyBiologicalProcessregulation of cell activation

EPHB2 TNFAIP8L2 METTL3 CARMIL2 FN1 LILRB2 ADAM8 TNFRSF21 SVEP1 CSK CD40LG ADAMTS18 TMEM131L SPINK5

3.81e-0475613314GO:0050865
GeneOntologyBiologicalProcesspositive regulation of immune system process

EPHB2 CFHR1 CARMIL2 LILRB2 TLR7 CFHR5 ADAM8 TNFRSF21 SVEP1 CD1B CD1C LIMK1 POLR3B CSK PTPRS TRIM56 CD40LG ASXL2 MASP2

3.89e-04124213319GO:0002684
GeneOntologyBiologicalProcessantigen processing and presentation, endogenous lipid antigen via MHC class Ib

CD1B CD1C

4.07e-0451332GO:0048006
GeneOntologyBiologicalProcesspositive regulation of axon extension

FN1 NTRK3 LIMK1 MEGF8

4.37e-04551334GO:0045773
GeneOntologyBiologicalProcessWnt signaling pathway, planar cell polarity pathway

FZD1 FZD7 FZD2 MED12

4.37e-04551334GO:0060071
GeneOntologyBiologicalProcesspositive regulation of neurogenesis

EPHB2 FN1 KALRN NTRK3 TIAM2 LIMK1 PTPRD PTPRF MEGF8

4.92e-043541339GO:0050769
GeneOntologyBiologicalProcesssynapse organization

EPHB2 KALRN LILRB2 NTRK3 ADGRB2 ACTN1 CLSTN1 SEMA4C FZD1 PTPRD PTPRF PTPRS ATP2B2

4.93e-0468513313GO:0050808
GeneOntologyBiologicalProcessregulation of neurogenesis

EPHB2 FN1 KALRN NTRK3 TIAM2 LIMK1 PTPRD PTPRF MEGF8 PTPRS ABCC8

5.15e-0451513311GO:0050767
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

EPHB2 PDE3B PSAP FN1 GPX1 ADGRB2 ACTN1 APOD ADAM8 RBM20 SEMA4C FZD1 FZD7 FZD8 FBN2 CSF3R ABCC8 FZD2 ATP2B2 MED12 SPINK5

5.25e-04148313321GO:0048646
GeneOntologyBiologicalProcesspostsynaptic density organization

LILRB2 NTRK3 PTPRD PTPRS

5.35e-04581334GO:0097106
GeneOntologyBiologicalProcessphosphatidylserine metabolic process

SERINC2 PLA2G15 SERINC5

5.43e-04251333GO:0006658
GeneOntologyBiologicalProcessregulation of axon extension

FN1 NTRK3 LIMK1 MEGF8 PTPRS

5.70e-041041335GO:0030516
GeneOntologyBiologicalProcessresponse to axon injury

NTRK3 APOD SCARF1 PTPRF PTPRS

5.96e-041051335GO:0048678
GeneOntologyBiologicalProcessmuscular septum morphogenesis

FZD1 FZD2

6.09e-0461332GO:0003150
GeneOntologyBiologicalProcesspresynapse assembly

NTRK3 FZD1 PTPRD PTPRS

6.09e-04601334GO:0099054
GeneOntologyBiologicalProcessregulation of cell size

FN1 NTRK3 LIMK1 CLCN3 MEGF8 PTPRS ATP2B2

6.51e-042251337GO:0008361
GeneOntologyBiologicalProcessregulation of postsynaptic density organization

LILRB2 PTPRD PTPRS

6.85e-04271333GO:1905874
GeneOntologyBiologicalProcessneuron projection fasciculation

EPHB2 TNFRSF21 MEGF8

7.63e-04281333GO:0106030
GeneOntologyBiologicalProcessaxonal fasciculation

EPHB2 TNFRSF21 MEGF8

7.63e-04281333GO:0007413
GeneOntologyBiologicalProcessregulation of T cell activation

TNFAIP8L2 METTL3 CARMIL2 LILRB2 ADAM8 TNFRSF21 CSK CD40LG TMEM131L SPINK5

7.84e-0445813310GO:0050863
GeneOntologyBiologicalProcessT cell differentiation

METTL3 PSAP CARMIL2 LILRB2 ADAM8 FZD7 FZD8 TMEM131L SPINK5

8.45e-043821339GO:0030217
GeneOntologyBiologicalProcessantigen processing and presentation, exogenous lipid antigen via MHC class Ib

CD1B CD1C

8.48e-0471332GO:0048007
GeneOntologyBiologicalProcessantigen processing and presentation of lipid antigen via MHC class Ib

CD1B CD1C

8.48e-0471332GO:0048003
GeneOntologyBiologicalProcesscell surface receptor protein tyrosine phosphatase signaling pathway

PTPRD PTPRF

8.48e-0471332GO:0007185
GeneOntologyBiologicalProcesspositive regulation of axonogenesis

FN1 NTRK3 TIAM2 LIMK1 MEGF8

8.65e-041141335GO:0050772
GeneOntologyBiologicalProcesssynapse assembly

EPHB2 NTRK3 ADGRB2 CLSTN1 SEMA4C FZD1 PTPRD PTPRS

8.82e-043081338GO:0007416
GeneOntologyBiologicalProcessmononuclear cell differentiation

METTL3 PSAP CARMIL2 LILRB2 ADAM8 FZD7 FZD8 CD40LG TMEM131L ASXL2 L3MBTL3 SPINK5

9.05e-0464013312GO:1903131
GeneOntologyBiologicalProcesspositive regulation of dendrite morphogenesis

EPHB2 KALRN PTPRD PTPRF

9.25e-04671334GO:0050775
GeneOntologyBiologicalProcesscirculatory system development

EPHB2 PDE3B FN1 NTRK3 GPX1 ADGRB2 APOD ADAM8 RBM20 SVEP1 FZD1 FZD7 FZD8 MEGF8 ABCC8 COL14A1 ASXL2 FZD2 MED12 SPINK5

9.33e-04144213320GO:0072359
GeneOntologyBiologicalProcesspositive regulation of cell morphogenesis

EPHB2 KALRN PTPRD PTPRF

1.03e-03691334GO:0010770
GeneOntologyBiologicalProcesscomplement activation

CFHR1 CFHR5 SVEP1 MASP2

1.09e-03701334GO:0006956
GeneOntologyBiologicalProcesscell activation

EPHB2 TNFAIP8L2 METTL3 PSAP CARMIL2 FN1 LILRB2 ACTN1 ADAM8 TNFRSF21 SVEP1 FZD7 FZD8 CD1C CSK CD40LG ADAMTS18 TMEM131L SPINK5

1.12e-03135613319GO:0001775
GeneOntologyBiologicalProcesspostsynaptic specialization organization

LILRB2 NTRK3 PTPRD PTPRS

1.15e-03711334GO:0099084
GeneOntologyBiologicalProcessregulation of extent of cell growth

FN1 NTRK3 LIMK1 MEGF8 PTPRS

1.17e-031221335GO:0061387
GeneOntologyBiologicalProcesspositive regulation of neuron projection development

EPHB2 KALRN NTRK3 FZD1 SCARF1 PTPRD RRN3

1.18e-032491337GO:0010976
GeneOntologyBiologicalProcessnegative regulation of cell-cell adhesion

TNFAIP8L2 METTL3 LILRB2 ADAM8 TNFRSF21 ADAMTS18 TMEM131L

1.26e-032521337GO:0022408
GeneOntologyBiologicalProcesspresynapse organization

NTRK3 FZD1 PTPRD PTPRS

1.27e-03731334GO:0099172
GeneOntologyBiologicalProcessinterferon-beta production

TLR7 POLR3B PTPRS TRIM56

1.27e-03731334GO:0032608
GeneOntologyBiologicalProcessregulation of interferon-beta production

TLR7 POLR3B PTPRS TRIM56

1.27e-03731334GO:0032648
GeneOntologyBiologicalProcessnegative regulation of peptide hormone secretion

PDE3B KALRN SIRT4 ABCC8

1.27e-03731334GO:0090278
GeneOntologyBiologicalProcessregulation of cell-cell adhesion

MAGI1 TNFAIP8L2 METTL3 CARMIL2 LILRB2 ADAM8 TNFRSF21 CSK CD40LG ADAMTS18 TMEM131L

1.35e-0358013311GO:0022407
GeneOntologyBiologicalProcesspositive regulation of dendritic spine morphogenesis

EPHB2 KALRN PTPRD

1.36e-03341333GO:0061003
GeneOntologyBiologicalProcesspostsynaptic density assembly

NTRK3 PTPRD PTPRS

1.36e-03341333GO:0097107
GeneOntologyBiologicalProcesspeptidyl-tyrosine dephosphorylation

PTPN12 PTPRF PTPRS

1.36e-03341333GO:0035335
GeneOntologyBiologicalProcesswound healing

EPHB2 CARMIL2 FN1 GPX1 ACTN1 ITGB5 SVEP1 FZD7 CD40LG ADAMTS18

1.36e-0349313310GO:0042060
GeneOntologyBiologicalProcessnegative regulation of peptide secretion

PDE3B KALRN SIRT4 ABCC8

1.41e-03751334GO:0002792
GeneOntologyCellularComponentcytoplasmic vesicle membrane

PSAP ABCA13 LILRB2 COPB2 TLR7 ACTN1 ADAM8 CD163 SEMA4C SCARF1 FZD7 CD1B CD1C ZFYVE9 CLCN3 CSF3R PTPRS SV2A ABCC8 SNX9 FZD2 ARHGAP21

1.77e-05130713022GO:0030659
GeneOntologyCellularComponentvesicle membrane

PSAP ABCA13 LILRB2 COPB2 TLR7 ACTN1 ADAM8 CD163 SEMA4C SCARF1 FZD7 CD1B CD1C ZFYVE9 CLCN3 CSF3R PTPRS SV2A ABCC8 SNX9 FZD2 ARHGAP21

2.19e-05132513022GO:0012506
GeneOntologyCellularComponentglutamatergic synapse

EPHB2 KALRN PRSS12 NTRK3 ADGRB2 ACTN1 GRM2 CLSTN1 ITGB5 SEMA4C LIMK1 PTPRD CLCN3 PTPRS SV2A ATP2B2

4.85e-0581713016GO:0098978
GeneOntologyCellularComponentsynaptic membrane

EPHB2 NTRK3 GRM2 CLSTN1 ITGB5 SEMA4C PTPRD CLCN3 PTPRF PTPRS KCNK1 ATP2B2

2.87e-0458313012GO:0097060
DomainFrizzled

FZD1 FZD7 FZD8 FZD2

7.57e-07111324IPR000539
DomainFrizzled

FZD1 FZD7 FZD8 FZD2

7.57e-07111324PF01534
DomainFrizzled

FZD1 FZD7 FZD8 FZD2

7.57e-07111324SM01330
Domainfn3

EPHB2 FN1 KALRN FSD1L PTPRD PTPRF CSF3R PTPRS COL14A1

2.27e-061621329PF00041
DomainFrizzled/SFRP

FZD1 FZD7 FZD8 FZD2

4.06e-06161324IPR015526
DomainFN3

EPHB2 FN1 KALRN FSD1L PTPRD PTPRF CSF3R PTPRS COL14A1

6.73e-061851329SM00060
DomainFRI

FZD1 FZD7 FZD8 FZD2

1.06e-05201324SM00063
DomainFN3

EPHB2 FN1 KALRN FSD1L PTPRD PTPRF CSF3R PTPRS COL14A1

1.21e-051991329PS50853
Domain-

FZD1 FZD7 FZD8 FZD2

1.30e-052113241.10.2000.10
DomainFN3_dom

EPHB2 FN1 KALRN FSD1L PTPRD PTPRF CSF3R PTPRS COL14A1

1.79e-052091329IPR003961
DomainFrizzled_dom

FZD1 FZD7 FZD8 FZD2

2.27e-05241324IPR020067
DomainFZ

FZD1 FZD7 FZD8 FZD2

2.27e-05241324PS50038
DomainFz

FZD1 FZD7 FZD8 FZD2

2.27e-05241324PF01392
DomainSushi

TPO CFHR1 CFHR5 SVEP1 MASP2

3.25e-05521325PF00084
DomainCCP

TPO CFHR1 CFHR5 SVEP1 MASP2

3.91e-05541325SM00032
DomainSUSHI

TPO CFHR1 CFHR5 SVEP1 MASP2

4.68e-05561325PS50923
DomainSushi_SCR_CCP_dom

TPO CFHR1 CFHR5 SVEP1 MASP2

5.10e-05571325IPR000436
DomainPDZ

MAGI1 SIPA1 TIAM2 LIMK1 LIMK2 ARHGAP21 SNTB1

6.47e-051411327PF00595
DomainGPCR_2_secretin-like

ADGRB2 FZD1 FZD7 FZD8 FZD2

6.54e-05601325IPR000832
DomainGPCR_2-like

ADGRB2 FZD1 FZD7 FZD8 FZD2

6.54e-05601325IPR017981
DomainG_PROTEIN_RECEP_F2_4

ADGRB2 FZD1 FZD7 FZD8 FZD2

7.08e-05611325PS50261
DomainEGF_1

TPO FN1 ADAM8 ITGB5 SVEP1 SCARF1 FBN2 MEGF8 MASP2

8.44e-052551329PS00022
DomainPDZ

MAGI1 SIPA1 TIAM2 LIMK1 LIMK2 ARHGAP21 SNTB1

8.78e-051481327SM00228
Domain-

MAGI1 SIPA1 TIAM2 LIMK1 LIMK2 ARHGAP21 SNTB1

9.55e-0515013272.30.42.10
DomainPDZ

MAGI1 SIPA1 TIAM2 LIMK1 LIMK2 ARHGAP21 SNTB1

9.96e-051511327PS50106
DomainEGF-like_CS

TPO FN1 ADAM8 ITGB5 SVEP1 SCARF1 FBN2 MEGF8 MASP2

1.01e-042611329IPR013032
DomainPDZ

MAGI1 SIPA1 TIAM2 LIMK1 LIMK2 ARHGAP21 SNTB1

1.04e-041521327IPR001478
DomainEGF_2

EPHB2 TPO ADAM8 ITGB5 SVEP1 SCARF1 FBN2 MEGF8 MASP2

1.13e-042651329PS01186
DomainPTPc

PTPN12 PTPRD PTPRF PTPRS

1.18e-04361324SM00194
DomainTYR_PHOSPHATASE_PTP

PTPN12 PTPRD PTPRF PTPRS

1.62e-04391324PS50055
DomainPTPase_domain

PTPN12 PTPRD PTPRF PTPRS

1.97e-04411324IPR000242
DomainY_phosphatase

PTPN12 PTPRD PTPRF PTPRS

1.97e-04411324PF00102
DomainEGF

TPO ADAM8 ITGB5 SVEP1 SCARF1 FBN2 MEGF8 MASP2

2.69e-042351328SM00181
DomainPkinase_Tyr

EPHB2 NTRK3 MAP3K20 LIMK1 LIMK2 CSK

3.11e-041291326PF07714
DomainEGF_CA

TPO SVEP1 FBN2 MEGF8 MASP2

3.60e-04861325PF07645
DomainSer-Thr/Tyr_kinase_cat_dom

EPHB2 NTRK3 MAP3K20 LIMK1 LIMK2 CSK

4.46e-041381326IPR001245
DomainIg-like_fold

EPHB2 FN1 KALRN LILRB2 NTRK3 SEMA4C CD1B CD1C FSD1L PTPRD PTPRF CSF3R PTPRS COL14A1

4.77e-0470613214IPR013783
DomainTDE1/TMS

SERINC2 SERINC5

4.89e-0451322IPR005016
DomainSerinc

SERINC2 SERINC5

4.89e-0451322PF03348
DomainSpectrin

KALRN ACTN4 ACTN1

5.51e-04231323PF00435
DomainEGF_Ca-bd_CS

TPO SVEP1 FBN2 MEGF8 MASP2

6.26e-04971325IPR018097
DomainEGF_CA

TPO SVEP1 FBN2 MEGF8 MASP2

6.87e-04991325PS01187
DomainEphrin_rec_like

EPHB2 TNFRSF21 SVEP1

7.08e-04251323SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHB2 TNFRSF21 SVEP1

7.08e-04251323IPR011641
DomainASX_HYDROXYL

TPO SVEP1 FBN2 MEGF8 MASP2

7.19e-041001325PS00010
DomainEFhand_Ca_insen

ACTN4 ACTN1

7.30e-0461322PF08726
DomainEF-hand_Ca_insen

ACTN4 ACTN1

7.30e-0461322IPR014837
DomainMHC_I_3

CD1B CD1C

7.30e-0461322PF16497
DomainPTPc_motif

PTPN12 PTPRD PTPRF PTPRS

8.03e-04591324SM00404
DomainTyr_Pase_cat

PTPN12 PTPRD PTPRF PTPRS

8.03e-04591324IPR003595
Domain-

EPHB2 FN1 KALRN NTRK3 SEMA4C CD1B CD1C FSD1L PTPRD PTPRF CSF3R PTPRS COL14A1

8.47e-04663132132.60.40.10
DomainEGF_extracell

ADAM8 ITGB5 SVEP1 SCARF1

8.56e-04601324IPR013111
DomainEGF_2

ADAM8 ITGB5 SVEP1 SCARF1

8.56e-04601324PF07974
DomainEGF-type_Asp/Asn_hydroxyl_site

TPO SVEP1 FBN2 MEGF8 MASP2

9.36e-041061325IPR000152
DomainSpectrin_repeat

KALRN ACTN4 ACTN1

1.10e-03291323IPR002017
DomainSAM_1

EPHB2 MAP3K20 L3MBTL3 ANKS1A

1.37e-03681324PF00536
DomainEGF_3

TPO ADAM8 SVEP1 SCARF1 FBN2 MEGF8 MASP2

1.42e-032351327PS50026
DomainSPEC

KALRN ACTN4 ACTN1

1.47e-03321323SM00150
DomainSpectrin/alpha-actinin

KALRN ACTN4 ACTN1

1.47e-03321323IPR018159
DomainPSI_integrin

ITGB5 MEGF8

1.73e-0391322PF17205
DomainIntegin_beta_N

ITGB5 MEGF8

1.73e-0391322IPR033760
DomainEGF_CA

TPO SVEP1 FBN2 MEGF8 MASP2

1.75e-031221325SM00179
DomainTyr_Pase_AS

PTPN12 PTPRD PTPRF PTPRS

1.78e-03731324IPR016130
DomainEGF-like_Ca-bd_dom

TPO SVEP1 FBN2 MEGF8 MASP2

1.88e-031241325IPR001881
DomainEGF-like_dom

TPO ADAM8 SVEP1 SCARF1 FBN2 MEGF8 MASP2

1.98e-032491327IPR000742
DomainEphrin_rec_like

EPHB2 SVEP1

2.62e-03111322PF07699
DomainPep_M12B_propep

ADAM8 ADAMTS7 ADAMTS18

2.62e-03391323PF01562
DomainPeptidase_M12B_N

ADAM8 ADAMTS7 ADAMTS18

2.62e-03391323IPR002870
DomainDISINTEGRIN_1

ADAM8 ADAMTS7 ADAMTS18

2.82e-03401323PS00427
DomainReprolysin

ADAM8 ADAMTS7 ADAMTS18

2.82e-03401323PF01421
DomainADAM_MEPRO

ADAM8 ADAMTS7 ADAMTS18

2.82e-03401323PS50215
DomainDISINTEGRIN_2

ADAM8 ADAMTS7 ADAMTS18

2.82e-03401323PS50214
DomainPeptidase_M12B

ADAM8 ADAMTS7 ADAMTS18

2.82e-03401323IPR001590
DomainDisintegrin_dom

ADAM8 ADAMTS7 ADAMTS18

3.02e-03411323IPR001762
DomainIg-like_dom

KALRN LILRB2 NTRK3 SEMA4C CD1B CD1C PTPRD PTPRF CSF3R PTPRS

3.06e-0350313210IPR007110
DomainTYR_PHOSPHATASE_1

PTPN12 PTPRD PTPRF PTPRS

3.24e-03861324PS00383
DomainTYR_PHOSPHATASE_dom

PTPN12 PTPRD PTPRF PTPRS

3.37e-03871324IPR000387
DomainTYR_PHOSPHATASE_2

PTPN12 PTPRD PTPRF PTPRS

3.37e-03871324PS50056
DomainSAM

EPHB2 MAP3K20 L3MBTL3 ANKS1A

3.52e-03881324SM00454
DomainPSI

ITGB5 SEMA4C MEGF8

3.70e-03441323IPR016201
Domain-

PTPN12 PTPRD PTPRF PTPRS

4.12e-039213243.90.190.10
DomainPSI

ITGB5 SEMA4C MEGF8

4.20e-03461323SM00423
DomainSAM_DOMAIN

EPHB2 MAP3K20 L3MBTL3 ANKS1A

4.62e-03951324PS50105
DomainSAM

EPHB2 MAP3K20 L3MBTL3 ANKS1A

4.98e-03971324IPR001660
DomainGrowth_fac_rcpt_

EPHB2 SVEP1 SCARF1 FBN2 MEGF8

5.04e-031561325IPR009030
DomainProt-tyrosine_phosphatase-like

PTPN12 PTPRD PTPRF PTPRS

5.35e-03991324IPR029021
DomainPROTEIN_KINASE_ATP

EPHB2 ERN1 KALRN NTRK3 CLK4 MAP3K20 LIMK1 LIMK2 CSK

5.36e-034591329PS00107
DomainTPR-like_helical_dom

RANBP2 COPB2 TRAPPC8 ZC3H7A TONSL TTC39A

6.28e-032331326IPR011990
Domain-

RANBP2 KALRN ECT2L TIAM2 PLEK2 ARHGAP21 SNTB1 ANKS1A

6.66e-0339113282.30.29.30
Domain-

EPHB2 MAP3K20 L3MBTL3 ANKS1A

6.80e-0310613241.10.150.50
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4

FZD1 FZD7 FZD8 FZD2

2.26e-06141004M47834
PathwayKEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY

FZD1 FZD7 FZD8 FZD2

4.06e-06161004M47823
PathwayWP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS

FN1 GPX1 FZD1 FZD7 FZD8 FZD2

7.06e-06661006M39642
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO

FZD1 FZD7 FZD8 FZD2

8.51e-06191004M47833
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

NTRK3 PTPRD PTPRF PTPRS

1.06e-05201004M27290
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

NTRK3 PTPRD PTPRF PTPRS

1.06e-05201004MM14991
PathwayPID_WNT_SIGNALING_PATHWAY

FZD1 FZD7 FZD8 FZD2

4.28e-05281004M77
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY

FN1 ACTN4 ACTN1 ITGB5

5.67e-05301004M47724
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD1 FZD7 FZD8 FZD2

1.18e-04361004M39699
PathwayKEGG_REGULATION_OF_ACTIN_CYTOSKELETON

FN1 ACTN4 ACTN1 ITGB5 TIAM2 LIMK1 LIMK2 CSK

1.35e-042131008M18306
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

EPHB2 KALRN LIMK1 LIMK2

2.17e-04421004M27308
PathwayWP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS

FZD1 FZD7 FZD8

2.19e-04171003M39525
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD1 FZD7 FZD8 FZD2

2.60e-04441004MM15878
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

FZD1 FZD7 FZD8 FZD2

2.84e-04451004M47412
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

FZD1 FZD7 FZD8 FZD2

3.10e-04461004M47409
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

PTPRD PTPRF PTPRS

3.62e-04201003MM15485
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

PTPRD PTPRF PTPRS

4.20e-04211003M27736
PathwayKEGG_BASAL_CELL_CARCINOMA

FZD1 FZD7 FZD8 FZD2

6.16e-04551004M17807
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR

CFHR1 CFHR5

7.34e-0461002M47880
PathwayREACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS

FZD1 FZD7 FZD8 FZD2

8.57e-04601004MM15150
PathwayREACTOME_SYNDECAN_INTERACTIONS

FN1 ACTN1 ITGB5

8.95e-04271003M27217
PathwayWP_WNT_SIGNALING

FZD1 FZD7 FZD8 FZD2

9.13e-04611004MM15893
Pubmed

Expression of Frizzled genes in developing and postnatal hair follicles.

FZD1 FZD7 FZD8 FZD2

4.35e-0810134415245425
Pubmed

Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.

FZD1 FZD7 FZD8 FZD2

4.35e-0810134417532316
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ITPRIPL2 KALRN ADGRB2 TNFRSF21 ITGB5 EML3 TIAM2 FZD1 FZD7 PTPRF MEGF8 SND1 ADAMTS7 PTPRS HELZ2 CPSF1 GCN1 ARHGAP21 MED12

5.27e-0811051341935748872
Pubmed

Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.

FZD1 FZD7 FZD2

5.59e-08313439813155
Pubmed

LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.

PTPRD PTPRF PTPRS

5.59e-083134331985401
Pubmed

Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.

PTPRD PTPRF PTPRS

5.59e-083134320139422
Pubmed

Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.

PTPRD PTPRF PTPRS

5.59e-083134333656439
Pubmed

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

FZD1 FZD7 FZD2

5.59e-083134327680706
Pubmed

Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse.

PTPRD PTPRF PTPRS

5.59e-08313439784606
Pubmed

Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.

FZD1 FZD7 FZD8 FZD2

6.81e-0811134424860427
Pubmed

PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.

NTRK3 PTPRD PTPRF PTPRS

6.81e-0811134425624497
Pubmed

Molecular determinants of WNT9b responsiveness in nephron progenitor cells.

FZD1 FZD7 FZD8 FZD2

6.81e-0811134430978219
Pubmed

Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.

FZD1 FZD7 FZD8 FZD2

6.81e-0811134417576136
Pubmed

Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.

FZD1 FZD7 FZD8 FZD2

6.81e-0811134417582687
Pubmed

The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.

PTPRD PTPRF PTPRS

2.23e-07413438524829
Pubmed

Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung.

FN1 FZD7 FZD8 FZD2

2.78e-0715134415617677
Pubmed

Protein tyrosine phosphatases expression during development of mouse superior colliculus.

PTPN12 PTPRD PTPRF PTPRS

4.82e-0717134419727691
Pubmed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

FZD1 FZD7 FZD8 FZD2

4.82e-0717134428733458
Pubmed

Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs.

PTPRD PTPRF PTPRS

5.56e-075134310777529
Pubmed

Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule.

PTPRD PTPRF PTPRS

5.56e-075134322357843
Pubmed

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.

FZD1 FZD7 FZD8 FZD2

7.81e-0719134421623369
Pubmed

Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases.

PTPRD PTPRF PTPRS

1.11e-066134319273906
Pubmed

FZD2 regulates limb development by mediating β-catenin-dependent and -independent Wnt signaling pathways.

FZD1 FZD7 FZD2

1.11e-066134336867021
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

NCAPD3 RANBP2 COPB2 GPX1 ACTN4 APOD PTPN12 FBN2 PTPRD PTPRF CSK PTPRS LPP TMEM131L GCN1 SNTB1

1.18e-069741341628675297
Pubmed

Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.

FZD1 FZD7 FZD8 FZD2

1.46e-0622134417064353
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

RANBP2 FN1 COPB2 WDR46 ACTN4 ACTN1 SND1 HELZ2 CPSF1 DDX20 SNX9 GCN1 MED12

1.59e-066531341322586326
Pubmed

Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.

PTPRD PTPRF PTPRS

1.94e-067134312376545
Pubmed

Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).

FZD1 FZD7 FZD8

1.94e-067134315370539
Pubmed

Modulation of apoptotic response by LAR family phosphatases-cIAP1 signaling during urinary tract morphogenesis.

PTPRD PTPRF PTPRS

1.94e-067134329073098
Pubmed

A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.

FN1 FZD7 FZD8 FZD2

2.11e-062413448626800
Pubmed

A role for Wnt/beta-catenin signaling in lens epithelial differentiation.

FZD1 FZD7 FZD8 FZD2

2.50e-0625134412812787
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

RANBP2 COPB2 ACTN4 RBM20 PTPN12 PPP4C ZFYVE9 PTPRD PTPRF CSK PTPRS LPP CPSF1 L3MBTL3 GCN1 SNTB1

3.05e-0610491341627880917
Pubmed

Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis.

FZD1 FZD7 FZD8

3.09e-068134310559494
Pubmed

Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.

PTPRD PTPRF PTPRS

3.09e-068134337591863
Pubmed

Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.

PTPRD PTPRF PTPRS

3.09e-068134328637841
Pubmed

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.

FZD1 FZD7 FZD2

3.09e-068134319388021
Pubmed

Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.

FZD1 FZD7 FZD2

4.62e-069134312067714
Pubmed

Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.

FZD1 FZD7 FZD2

4.62e-069134323095888
Pubmed

A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.

FZD1 FZD7 FZD2

4.62e-06913439707618
Pubmed

3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).

FZD1 FZD7 FZD8 FZD2

4.64e-0629134418364260
Pubmed

A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain.

PTPRD PTPRF PTPRS

9.02e-061113437832766
Pubmed

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.

FZD1 FZD7 FZD8 FZD2

1.13e-0536134424151333
Pubmed

Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder.

PTPRD PTPRS SV2A

1.20e-0512134331875546
Pubmed

Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase.

ACTN4 ACTN1 LPP

1.20e-0512134315465019
Pubmed

Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.

PTPRD PTPRF PTPRS

1.20e-051213439624153
Pubmed

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.

FZD1 FZD7 FZD8 FZD2

1.26e-0537134415342465
Pubmed

Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.

FZD1 FZD7 FZD8 FZD2

1.26e-0537134418800919
Pubmed

Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.

FZD1 FZD7 FZD8 FZD2

1.40e-0538134421041481
Pubmed

Tissue-specific requirements of beta-catenin in external genitalia development.

FZD1 FZD7 FZD8 FZD2

1.40e-0538134418635608
Pubmed

The small GTPase RhoA regulates the LIMK1/2-cofilin pathway to modulate cytoskeletal dynamics in oocyte meiosis.

LIMK1 LIMK2

1.47e-052134229319181
Pubmed

Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens.

CD1B CD1C

1.47e-052134210899914
Pubmed

Fibronectin fragments and the cleaving enzyme ADAM-8 in the degenerative human intervertebral disc.

FN1 ADAM8

1.47e-052134225010013
Pubmed

Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex.

NTRK3 PTPRS

1.47e-052134221262467
Pubmed

Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition.

LIMK1 LIMK2

1.47e-052134216455074
Pubmed

An analysis of splicing, actin-binding properties, heterodimerization and molecular interactions of the non-muscle α-actinins.

ACTN4 ACTN1

1.47e-052134223557398
Pubmed

Cloning and biochemical characterization of LIMK-2, a protein kinase containing two LIM domains.

LIMK1 LIMK2

1.47e-05213429089416
Pubmed

Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin.

EPHB2 KALRN

1.47e-052134212546821
Pubmed

The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization.

PTPRD PTPRF

1.47e-05213427665159
Pubmed

LIMK1 and LIMK2 are important for metastatic behavior and tumor cell-induced angiogenesis of pancreatic cancer cells.

LIMK1 LIMK2

1.47e-052134220047470
Pubmed

Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells.

ACTN4 ACTN1

1.47e-052134220156433
Pubmed

Involvement of LIMK1/2 in actin assembly during mouse embryo development.

LIMK1 LIMK2

1.47e-052134229943641
Pubmed

Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.

SERINC2 SERINC5

1.47e-052134229268082
Pubmed

Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain.

LIMK1 LIMK2

1.47e-052134228669900
Pubmed

Self-association of LIM-kinase 1 mediated by the interaction between an N-terminal LIM domain and a C-terminal kinase domain.

LIMK1 LIMK2

1.47e-05213428980133
Pubmed

LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice.

LIMK1 LIMK2

1.47e-052134223239465
Pubmed

Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion.

EPHB2 TIAM2

1.47e-052134227597758
Pubmed

Distinct forms of the actin cross-linking protein α-actinin support macropinosome internalization and trafficking.

ACTN4 ACTN1

1.47e-052134234010028
Pubmed

The Diagnostic and Prognostic Value of LIMK1/2: A Pan-Cancer Analysis.

LIMK1 LIMK2

1.47e-052134234686503
Pubmed

Differences in susceptibility of inbred and outbred infant mice to enterotoxigenic Escherichia coli of bovine, porcine and human origin.

FN1 FBN2

1.47e-05213422179554
Pubmed

Phosphorylated LIM kinases colocalize with gamma-tubulin in centrosomes during early stages of mitosis.

LIMK1 LIMK2

1.47e-052134218000399
Pubmed

Three-dimensional visualization of extracellular matrix networks during murine development.

FN1 FBN2

1.47e-052134229352963
Pubmed

Saposin C is required for lipid presentation by human CD1b.

PSAP CD1B

1.47e-052134214716313
Pubmed

Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology.

ACTN4 ACTN1

1.47e-052134220037648
Pubmed

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation.

CFHR1 CFHR5

1.47e-052134235392081
Pubmed

HAMLET binding to α-actinin facilitates tumor cell detachment.

ACTN4 ACTN1

1.47e-052134221408150
Pubmed

Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation.

LIMK1 LIMK2

1.47e-052134225344584
Pubmed

Actinin-1 and actinin-4 play essential but distinct roles in invadopodia formation by carcinoma cells.

ACTN4 ACTN1

1.47e-052134228797528
Pubmed

Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion.

LIMK1 LIMK2

1.47e-052134231641031
Pubmed

α-actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation.

ACTN4 ACTN1

1.47e-052134223454549
Pubmed

Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts.

FZD1 FZD2

1.47e-052134220189955
Pubmed

Circulating complement factor H-related proteins 1 and 5 correlate with disease activity in IgA nephropathy.

CFHR1 CFHR5

1.47e-052134228673452
Pubmed

A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.

CFHR1 CFHR5

1.47e-052134228729035
Pubmed

The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma.

PTPRD PTPRS

1.47e-05213429566880
Pubmed

LIM kinases: function, regulation and association with human disease.

LIMK1 LIMK2

1.47e-052134217294230
Pubmed

The lipoma preferred partner LPP interacts with alpha-actinin.

ACTN1 LPP

1.47e-052134212615977
Pubmed

Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.

FZD1 FZD7 FZD2

1.55e-0513134321246654
Pubmed

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.

FZD1 FZD7 FZD8 FZD2

3.30e-0547134428813421
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

FZD1 FZD7 FZD8 FZD2

3.30e-0547134433141892
Pubmed

Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.

FZD1 FZD7 FZD8 FZD2

3.30e-0547134418351675
Pubmed

Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk.

MAGI1 ESRP1 FZD1 FZD7

3.30e-0547134432253237
Pubmed

Cooperative and independent functions of FGF and Wnt signaling during early inner ear development.

FZD1 FZD7 FZD8

3.66e-0517134326443994
Pubmed

Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.

FZD1 FZD7 FZD8 FZD2

3.90e-0549134419562671
Pubmed

Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.

FZD1 FZD7 FZD8 FZD2

4.23e-0550134427510977
Pubmed

ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.

FN1 FBN2 ADAMTS18

4.37e-0518134339040056
Pubmed

Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control.

RNF25 GCN1

4.41e-053134237651229
Pubmed

GPER stabilizes F-actin cytoskeleton and activates TAZ via PLCβ-PKC and Rho/ROCK-LIMK-Cofilin pathway.

LIMK1 LIMK2

4.41e-053134231277940
Pubmed

Direct measurement of antigen binding properties of CD1 proteins using fluorescent lipid probes.

CD1B CD1C

4.41e-053134214551186
Pubmed

LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP.

LIMK1 LIMK2

4.41e-053134227116935
Pubmed

K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution.

RNF25 GCN1

4.41e-053134237951215
Pubmed

RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks.

RNF25 GCN1

4.41e-053134237951216
InteractionSCGB1C1 interactions

FZD1 FZD7 COL14A1 FZD2

1.17e-06131314int:SCGB1C1
InteractionDLG2 interactions

KALRN SEMA4C FZD1 FZD7 CSK ATP2B2

1.68e-05831316int:DLG2
InteractionPTPRQ interactions

ACTN1 PTPRF PTPRS ATP2B2

1.94e-05251314int:PTPRQ
InteractionTOP3B interactions

ITPRIPL2 KALRN ADGRB2 ACTN4 ACTN1 TNFRSF21 ITGB5 EML3 TIAM2 FZD1 FZD7 ZC3H7A PTPRF MEGF8 SND1 ADAMTS7 PTPRS TRIM56 HELZ2 CPSF1 DDX20 GCN1 ARHGAP21 MED12

2.40e-05147013124int:TOP3B
Cytoband8q24.23

FAM135B CPSF1

5.05e-05413428q24.23
GeneFamilyG protein-coupled receptors, Class F frizzled

FZD1 FZD7 FZD8 FZD2

3.43e-07111054286
GeneFamilyFibronectin type III domain containing

EPHB2 FN1 KALRN FSD1L PTPRD PTPRF CSF3R PTPRS COL14A1

3.87e-071601059555
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

TPO CFHR1 CFHR5 SVEP1 MASP2

1.98e-055710551179
GeneFamilyPDZ domain containing

MAGI1 SIPA1 TIAM2 LIMK1 LIMK2 ARHGAP21 SNTB1

2.95e-0515210571220
GeneFamilyActinins

ACTN4 ACTN1

1.99e-04410521112
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRD PTPRF PTPRS

2.35e-04211053813
GeneFamilyADAM metallopeptidase domain containing|CD molecules

LILRB2 ADAM8 TNFRSF21 CD163 CD1B CD1C CSF3R CD40LG

2.10e-033941058471
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

KALRN NTRK3 PTPRD PTPRF PTPRS

2.48e-031611055593
GeneFamilyLIM domain containing

LIMK1 LIMK2 LPP

4.89e-035910531218
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS7 ADAMTS18

5.36e-0319105250
CoexpressionPILON_KLF1_TARGETS_UP

FN1 FZD1 PLEK2 FBN2 PTPRD CLCN3 PTPRF ABCC8 LPP COL14A1 TTC39A ASXL2 SNTB1

1.81e-0650313313M2226
CoexpressionPILON_KLF1_TARGETS_UP

FN1 FZD1 PLEK2 FBN2 PTPRD CLCN3 PTPRF ABCC8 LPP COL14A1 TTC39A ASXL2 SNTB1

4.00e-0654113313MM1061
CoexpressionTRAVAGLINI_LUNG_OLR1_CLASSICAL_MONOCYTE_CELL

RANBP2 ITPRIPL2 PSAP LILRB2 GPX1 MAP3K20 ACTN1 ADAM8 CD163 LIMK2 PTPN12 PPP4C CSF3R MTF1 SNX9

4.28e-0672413315M41700
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

ZNF410 METTL3 PSAP ITGB5 PPP4C PTPRD DAZAP1 SND1 LPP ARID5B KCNK1 L3MBTL3

4.87e-0646713312M1347
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

ZNF410 METTL3 PSAP ITGB5 PPP4C PTPRD DAZAP1 SND1 LPP ARID5B KCNK1 L3MBTL3

6.99e-0648413312MM999
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HPERIC

CFHR1 ITPRIPL2 FN1 MAP3K20 ACTN1 TNFRSF21 ITGB5 EML3 SVEP1 FZD1 LPP ARID5B ADAMTS18 SERINC5 CCT8L1P

1.30e-0579513315M39050
CoexpressionFULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP

TNFAIP8L2 FN1 MAP3K20 SERINC2 ACTN1 ADAM8 SCARF1 LIMK1 FSD1L SND1 CSK LPP

4.51e-0558513312M6659
CoexpressionGSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_NFKBP50_KO_MACROPHAGE_DN

ACTN4 SERINC2 PPP4C CD40LG TTC39A SNX9 L3MBTL3

7.26e-051991337M8113
CoexpressionGSE41978_ID2_KO_AND_BIM_KO_VS_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_UP

FN1 RNF25 SIRT4 PTPRF INMT TMEM131L SNTB1

7.26e-051991337M9566
CoexpressionGSE3982_EOSINOPHIL_VS_MAST_CELL_UP

LILRB2 LIMK2 MTF1 GZMK TMEM131L COL14A1 ATP2B2

7.26e-051991337M5397
CoexpressionGSE44732_UNSTIM_VS_IL27_STIM_IMATURE_DC_UP

CLSTN1 FZD1 SCARF1 CD1B GPBP1L1 MEGF8 HELZ2

7.49e-052001337M9699
CoexpressionGSE1432_CTRL_VS_IFNG_24H_MICROGLIA_UP

EPHB2 PSAP TNFRSF21 ITGB5 CD163 SERINC5 ANKS1A

7.49e-052001337M3407
CoexpressionGSE27786_LIN_NEG_VS_NKCELL_DN

TNFAIP8L2 ITPRIPL2 PSAP TRAPPC8 SIPA1 ZC3H7A PTPN12

7.49e-052001337M4784
CoexpressionGSE29618_BCELL_VS_MONOCYTE_DAY7_FLU_VACCINE_DN

PSAP GPX1 CD163 FZD1 FBN2 CSF3R SERINC5

7.49e-052001337M4955
CoexpressionGSE29618_PDC_VS_MDC_DAY7_FLU_VACCINE_DN

ACTN1 ADAM8 CD163 FZD1 CD1B CD1C LIMK1

7.49e-052001337M4971
CoexpressionGSE29618_BCELL_VS_MDC_DAY7_FLU_VACCINE_DN

PSAP GPX1 ACTN1 ADAM8 FZD1 CD1B CD1C

7.49e-052001337M4962
CoexpressionGSE17580_TREG_VS_TEFF_S_MANSONI_INF_DN

PRSS12 NTRK3 CLK4 ACTN1 ITGB5 LPP GZMK

7.49e-052001337M3674
CoexpressionGSE3982_EOSINOPHIL_VS_CENT_MEMORY_CD4_TCELL_UP

CLK4 COPB2 ACTN1 ADAM8 LIMK2 PTPN12 PPP4C

7.49e-052001337M5418
CoexpressionGSE40274_FOXP3_VS_FOXP3_AND_EOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP

PRSS12 TLR7 PLA2G15 KLHL22 PTPN12 ARID5B L3MBTL3

7.49e-052001337M9121
CoexpressionYAGI_AML_WITH_T_8_21_TRANSLOCATION

NTRK3 CLSTN1 TNFRSF21 LIMK2 PTPN12 CSF3R CSK ARID5B MED12

1.23e-043721339M19261
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

PRSS12 APOD TNFRSF21 ITGB5 LIMK2 PTPRD PTPRS INMT L3MBTL3

5.96e-0918813498231e635706a296db6b6da1029a33bbc1b52478e
ToppCell10x5'-GI_large-bowel-Myeloid_Monocytic|GI_large-bowel / Manually curated celltypes from each tissue

FN1 LILRB2 PLA2G15 ITGB5 CD163 FZD1 FBN2 CSF3R FZD2

5.96e-091881349d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes|GI_large-bowel / Manually curated celltypes from each tissue

FN1 LILRB2 PLA2G15 ITGB5 CD163 FZD1 FBN2 CSF3R FZD2

5.96e-0918813490bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW12-Neuronal-GABAergic_neurons|GW12 / Sample Type, Dataset, Time_group, and Cell type.

EML3 FZD1 POLR3B KCNK1 HELZ2 PCDHGB4 FAM181A C2CD6

1.41e-071951348efdea22118d5be46c5abfe8e3fbe39503390665d
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFHR1 ITPRIPL2 MAP3K20 TNFRSF21 CD1B CD1C FZD2

4.78e-071561347841d653d74c4de41d2f9a114f6ccb92d6a1ebc24
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CFHR1 ITPRIPL2 MAP3K20 TNFRSF21 CD1B CD1C FZD2

4.78e-071561347a917b3e799a7b2a3c7f36af61f2b69292c0fb5c0
ToppCellnormal_Lung-Myeloid_cells-Pleural_Mac|normal_Lung / Location, Cell class and cell subclass

LILRB2 GPX1 FZD1 PLEK2 CD1B CD1C CSF3R

5.43e-071591347f95a5570bf153fc5c598aba855db6b47ba818463
ToppCell390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|390C / Donor, Lineage, Cell class and subclass (all cells)

TNFAIP8L2 LILRB2 TLR7 PLA2G15 ITGB5 CD163 PLEK2

8.19e-0716913472c851b2703c7b8b656026f996f5fc027e4a79b36
ToppCelldroplet-Spleen-SPLEEN-30m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 ESRP1 APOD SEMA4C PTPRF PTPRS SERINC5

9.21e-07172134730916a902c151907745756d14327e24adc34afef
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet-BEST2+_Goblet_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SERINC2 CLSTN1 PTPRF RASEF TTC39A MUC2 SPINK5

1.20e-061791347c833ded1f9e87be2ba2037820d92a389560b711c
ToppCellnormal_Lymph_Node-Myeloid_cells-Pleural_Mac|normal_Lymph_Node / Location, Cell class and cell subclass

ITPRIPL2 LILRB2 GPX1 CD163 CD1C CSF3R FZD2

1.30e-061811347921e917f83105896ad8918dc134b871708024021
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFHR1 APOD ITGB5 SVEP1 FZD1 INMT FZD2

1.50e-061851347eaa54b76743628c89b4310be57b87fa92b75fd37
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFHR1 APOD ITGB5 SVEP1 FZD1 INMT FZD2

1.50e-061851347f7f4c921d248c637351e2e882589b99ba7f04b66
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFHR1 APOD ITGB5 SVEP1 FZD1 INMT FZD2

1.50e-061851347ff38a15af3dec36d9993f06623591872b5d1da9a
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

EPHB2 NTRK3 APOD ITGB5 FBN2 COL14A1 FZD2

1.55e-061861347c0a036096c2cb23305605b8aaf18869d6e0fb512
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

FN1 KALRN NTRK3 ACTN1 RBM20 LPP COL14A1

1.61e-061871347464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellE16.5-samps-Mesenchymal|E16.5-samps / Age Group, Lineage, Cell class and subclass

FN1 MAP3K20 ACTN1 SVEP1 PTPRD PTPRS COL14A1

1.67e-0618813473f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCell3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-cDC2|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNFAIP8L2 LILRB2 TLR7 ADAM8 CD163 CD1C CSF3R

1.67e-061881347239bec13476dd43bebc2c6eba8d1fe35f2744673
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LILRB2 CD163 SCARF1 CD1B CD1C CSF3R FZD2

1.73e-061891347e4b2f00cb3675a4d94e8807d6ff99cc55f9ed233
ToppCell(2)_Dendritic_Cells|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

TNFAIP8L2 LILRB2 ADAM8 CD163 CD1B CD1C CSF3R

1.79e-0619013475163a5be95fb6c2609bfa3d69166af172f74e724
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 KALRN NTRK3 MAP3K20 ACTN1 SVEP1 TMEM131L

1.79e-06190134770c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCelldroplet-Mammary_Gland-nan-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERINC2 TNFRSF21 RBM20 PTPRF ABCC8 KCNK1 RASEF

1.85e-061911347c21e7904e06a5c90176f935f6822dbb5a1aa6755
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FN1 APOD ITGB5 SVEP1 PTPRD INMT COL14A1

1.85e-061911347997abf0cc5873bed0372c4a333ed307fa72774d2
ToppCelldroplet-Fat-Scat-18m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESRP1 SERINC2 RBM20 PTPRF ABCC8 KCNK1 RASEF

1.92e-0619213474098b5170c9995718758a082d1b8bcb86d5a289e
ToppCelldroplet-Fat-Scat-18m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESRP1 SERINC2 RBM20 PTPRF ABCC8 KCNK1 RASEF

1.92e-061921347936028fe851e8dd2b906df0210acc574c017b499
ToppCelldroplet-Fat-Scat-18m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESRP1 SERINC2 RBM20 PTPRF ABCC8 KCNK1 RASEF

1.92e-06192134762e55ed0d46b2e7b07dc42399972a099576cbc5f
ToppCell10x5'v1-week_17-19-Myeloid_DC-DC-pDC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ERN1 GPX1 TLR7 TNFRSF21 PTPRS KCNK1 TTC39A

1.99e-0619313472a48e72f3df2ad64e1680fca759be8fd2190771e
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PSAP LILRB2 TLR7 TNFRSF21 ITGB5 CD163 CSF3R

2.06e-0619413478e2819a9d0529f7b2de1a7c1190575175d6173ee
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ABCA13 ACTN1 FBN2 PTPRD CSF3R ABCC8 COL14A1

2.13e-061951347d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellMonocytes-NUPR1+_Monocytes|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

TNFAIP8L2 LILRB2 TLR7 PLA2G15 CD163 PLEK2 CSF3R

2.13e-0619513475e12201ce7ba912e7faa123ca200e609252ba288
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ABCA13 ACTN1 FBN2 PTPRD CSF3R ABCC8 COL14A1

2.13e-06195134719853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCelldroplet-Mammary_Gland-nan-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERINC2 TNFRSF21 RBM20 PTPRF ABCC8 KCNK1 RASEF

2.13e-06195134718220efbd2d6ce6aa7501744fe430b6b46f2fc30
ToppCell(1)_Osterolineage_cells-(11)_OLC-2|World / Cell class and subclass of bone marrow stroma cells in homeostatis

FN1 PRSS12 ITGB5 FZD1 PTPRS COL14A1 FZD2

2.13e-06195134778978d85273e5463a7f43e4c121e647fa6aba42b
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDE3B ERN1 ACTN4 GZMK ARID5B CD40LG SNX9

2.20e-061961347072e0e29be4639344ead4ea6ad521e3338f5f8af
ToppCelldroplet-Mammary_Gland-nan-18m-Epithelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERINC2 TNFRSF21 RBM20 PTPRF ABCC8 KCNK1 RASEF

2.20e-06196134700f9171da4c791619e8c4c8c3c7da578c96a30ed
ToppCellILEUM-non-inflamed-(3)_Resident_macrophages|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TNFAIP8L2 PSAP LILRB2 GPX1 TNFRSF21 CD163 CSF3R

2.28e-0619713473af24354b6a93c7d105b9fa6549cf215107b9203
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TNFAIP8L2 ITPRIPL2 PSAP LILRB2 GPX1 CD163 CD1C

2.28e-061971347e2c53742c7d8d1b63d93843f82330b9e20f1faa6
ToppCellILEUM-non-inflamed-(3)_MNP|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TNFAIP8L2 PSAP LILRB2 GPX1 CD163 CD1C CSF3R

2.28e-06197134764fdc12e7ffade669cc1de081b10e84a27f0d1b5
ToppCellMonocytes-cDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

ITPRIPL2 GPX1 MAP3K20 CD1B CD1C CSF3R FZD2

2.28e-0619713473388c104af4c6a05988e102627e0c5e34d9dcc45
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-myeloid_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TNFAIP8L2 ITPRIPL2 PSAP LILRB2 GPX1 CD163 CSF3R

2.28e-0619713479838dbd1623babf8de7e9126a28fe5d3666bce42
ToppCellMonocytes-Phagocytic_CD16+_macrophages|World / Immune cells in Kidney/Urine in Lupus Nephritis

EPHB2 PSAP LILRB2 GPX1 ITGB5 CD163 CSF3R

2.35e-06198134709009cc966bf1503c3b15dfa079a6c5f6ad1f507
ToppCellSigmoid-Macrophage-Macrophage|Sigmoid / Region, Cell class and subclass

EPHB2 LILRB2 ACTN1 TNFRSF21 ITGB5 CD163 CSF3R

2.52e-0620013479ee3a799de7bade1bfe94b6827461633f02bc1dc
ToppCellSigmoid-(6)_Macrophage-(60)_Macrophage|Sigmoid / shred on region, Cell_type, and subtype

EPHB2 LILRB2 ACTN1 TNFRSF21 ITGB5 CD163 CSF3R

2.52e-062001347ad84a83a5a1893f7b053d39eddeca851463a8ff0
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FN1 LILRB2 CD163 PLEK2 CD1C FZD2

8.76e-061591346210ac7fa89514a84f38d9f42254e38fbc2bc5f42
ToppCell21-Trachea-Epithelial-Submucosal_gland_basal|Trachea / Age, Tissue, Lineage and Cell class

NTRK3 APOD FZD1 FZD7 ADAMTS18 COL14A1

8.76e-0615913464f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCellfacs-Liver-Non-hepatocytes-3m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 TNFAIP8L2 TLR7 CSF3R PTPRS FAM181A

9.08e-061601346237430af14830b38e58da8a4224036e5c6b71c5b
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_8|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

KALRN SCARF1 PLEK2 FZD7 CD1C TTC39A

9.41e-0616113467e0b8119cea208c0b4a0dffdf94ff6137d0b4c90
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESRP1 KCNK1 RASEF TTC39A MUC2 SPINK5

1.28e-0517013462c5a1469e5743870e96e6c2cc92f0c5096b79f51
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESRP1 KCNK1 RASEF TTC39A MUC2 SPINK5

1.28e-0517013469bea81031cdfe45e8cddac3a3afd9ca6c331c45a
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9|TCGA-Bladder / Sample_Type by Project: Shred V9

ITPRIPL2 ACTN4 CLSTN1 LIMK2 KCNK1 FBXO34

1.33e-051711346adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCellLV-13._Vascular_Smooth_Muscle|LV / Chamber and Cluster_Paper

FN1 KALRN NTRK3 ACTN1 LPP COL14A1

1.33e-051711346e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCellfacs-Marrow-T-cells-24m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 PSAP TLR7 APOD PTPRF PTPRS

1.42e-051731346ca3d2a9562734f76127e3e7d54c10b63e95141bb
ToppCellfacs-Marrow-T-cells-24m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 PSAP TLR7 APOD PTPRF PTPRS

1.42e-05173134619a9e10885173d7712996be8660a3a5a7a9aa39f
ToppCell390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

EPHB2 TNFAIP8L2 PLA2G15 ITGB5 CD163 PLEK2

1.42e-0517313461f725ff16e28636b20ef26f3fa9be8b47c89378d
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KALRN NTRK3 ACTN1 RBM20 LPP COL14A1

1.42e-051731346cb6389536195443633adb06e5f1b7483530773d1
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITPRIPL2 PSAP ACTN1 PLA2G15 ITGB5 CD163

1.46e-051741346dc4298c1d9359f7e37454e9451f889017227d5cf
ToppCell10x5'-blood-Myeloid_Dendritic|blood / Manually curated celltypes from each tissue

TNFRSF21 CD1B CD1C PTPRS PCDHGB4 TTC39A

1.51e-0517513461c48eec300d5a6d4a810947b995af3b8c0a5a601
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFAIP8L2 PDE3B TNFRSF21 PLA2G15 ITGB5 TMEM131L

1.56e-051761346d687e6c3f9043f2574d072f815b8c2258f9dc7b5
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

FN1 APOD SVEP1 INMT BHMT2 COL14A1

1.56e-0517613462e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFAIP8L2 PDE3B TNFRSF21 PLA2G15 ITGB5 TMEM131L

1.56e-0517613464f37854124d77ee64dcb40fd491eaed2ba389891
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Myeloid-microglial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFAIP8L2 PDE3B TNFRSF21 PLA2G15 ITGB5 TMEM131L

1.56e-0517613460afba8707b847e5bdf6f38fe4379967631fe2240
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

FN1 APOD SVEP1 INMT BHMT2 COL14A1

1.56e-051761346f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PSAP KALRN ITGB5 INMT ADAMTS18 SNX9

1.72e-051791346906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD207+CD1a+_LCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

TNFAIP8L2 KALRN SCARF1 PLEK2 CD1B CD1C

1.77e-051801346289f8c4b53ffd164fee1f459a9315c0deb5f76d0
ToppCellmetastatic_Brain-Myeloid_cells-Pleural_Mac|metastatic_Brain / Location, Cell class and cell subclass

TNFAIP8L2 PSAP GPX1 CD163 CD1B CD1C

1.77e-0518013467de1c8ab1152fa517c6b4830d93ff53a19fca3d7
ToppCellControl-Fibroblasts-Airway_smooth_muscle|Control / group, cell type (main and fine annotations)

FN1 KALRN NTRK3 ACTN1 RBM20 COL14A1

1.77e-051801346d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCelldroplet-Lung-nan-3m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESRP1 SERINC2 PTPRF KCNK1 RASEF SPINK5

1.89e-051821346cfba75c1ffc39ac76db9e8e27394731942882b30
ToppCelldroplet-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESRP1 SERINC2 PTPRF KCNK1 RASEF SPINK5

1.89e-051821346d836bfdc298ecd3558a973e393a329eb8bd59d79
ToppCelldroplet-Lung-nan-3m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESRP1 SERINC2 PTPRF KCNK1 RASEF SPINK5

1.89e-0518213467e7c7a26460d3003cdf0c0ffb96208a566aa09a7
ToppCellRA-13._Vascular_Smooth_Muscle|RA / Chamber and Cluster_Paper

FN1 KALRN NTRK3 ACTN1 LPP COL14A1

1.95e-051831346818fd886e0188091310825f9145fa53328f2c979
ToppCellDendritic_Cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

GPX1 ADAM8 PLEK2 CD1B CD1C PCDHGB4

1.95e-051831346dd09e39e8ca282ff0f470e0652d519e190badd0b
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

EPHB2 ADAM8 PLEK2 CD1B CD1C FBN2

1.95e-051831346bd78e5c2670e67b4363078e3ca5a5b7081d24b7e
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

EPHB2 ADAM8 PLEK2 CD1B CD1C FBN2

1.95e-051831346d1bf3abf42eb9d7facf775becf1338d1faadd647
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Macrophages|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNFAIP8L2 PSAP LILRB2 CD163 CD1B CSF3R

1.95e-05183134692d5a61b57851090eba558f19e2a7010043eff81
ToppCellRA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

FN1 KALRN NTRK3 ACTN1 LPP COL14A1

1.95e-051831346cae2ee08f985a6f005b4b8e959e465350315156a
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

EPHB2 FN1 APOD ITGB5 COL14A1 FZD2

2.01e-05184134601257e5c12e38b849fd3d9496c43ded666249ba5
ToppCellmild-Myeloid-mDC|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GPX1 MAP3K20 TNFRSF21 CD1B CD1C FZD2

2.01e-0518413468b37c00d59d9992d3b43268991da7bb94646c70e
ToppCellFrontal_cortex-Neuronal-Excitatory|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

KALRN PRSS12 ADGRB2 SERINC2 GRM2 CLSTN1

2.01e-0518413466e17c8151d6dc543de16d804db956c63c3fda414
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Monocytes|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNFAIP8L2 PSAP LILRB2 CD163 CD1B CSF3R

2.07e-05185134600a991e63e9ac6de3f48a96e3be6073f90cbb442
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Dendritic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LILRB2 MAP3K20 TNFRSF21 SCARF1 CD1C PPP4C

2.07e-0518513460a87d2ee8fffc812224c05a26c729733a5e64d2c
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LILRB2 MAP3K20 TNFRSF21 SCARF1 CD1C PPP4C

2.07e-051851346e63fde030be822ebf32143a41f8cc684cb720f5b
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined|Fibroblasts / Location, Cell class and cell subclass

TNFRSF21 ITGB5 LIMK2 PTPRD PTPRS L3MBTL3

2.13e-051861346403ac98f72a42721f84fbd7826f251a88ae534a2
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB2 APOD RBM20 FZD1 COL14A1 FZD2

2.13e-0518613467c1807fca590cdccf7f5734460bac228d33964ca
ToppCell3'-Adult-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNFAIP8L2 PSAP LILRB2 CD163 CD1C CSF3R

2.20e-0518713468e1d6d25db5b5c91a651bb2d66edfcf073a31704
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

FN1 KALRN NTRK3 ACTN1 LPP COL14A1

2.26e-05188134634e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell5'-Adult-SmallIntestine-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EPHB2 PLEK2 KCNK1 RASEF TTC39A MUC2

2.26e-05188134691fa9cc29cbc88d3c29590ecee5c8ce858ac0aa7
ToppCellfacs-Lung-EPCAM-18m-Epithelial-Basal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 SERINC2 TNFRSF21 PLEK2 LIMK2 PTPRF

2.33e-051891346783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCellMacrophages-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

FN1 TLR7 ACTN1 PLA2G15 ITGB5 CD163

2.33e-051891346c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

FN1 KALRN NTRK3 ACTN1 LPP COL14A1

2.33e-0518913466b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellfacs-Lung-EPCAM-18m-Epithelial-respiratory_basal_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 SERINC2 TNFRSF21 PLEK2 LIMK2 PTPRF

2.33e-05189134688b72fafbe58463543e0818f27f3dd9e5b4d34d2
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FN1 GPX1 APOD SVEP1 INMT COL14A1

2.40e-051901346d13fd234caa3fc69d8a59bc0060cdacdf716ee55
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PSAP GPX1 PLA2G15 ITGB5 CD163 ARHGAP21

2.40e-0519013460a944da2aaaef9289b2a4ffe360b0338724fd59b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B MAP3K20 ACTN1 ABCC8 TMEM131L COL14A1

2.40e-051901346562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCellMonocytes-Tissue-resident_macrophages|World / Immune cells in Kidney/Urine in Lupus Nephritis

ITPRIPL2 FN1 GPX1 CD163 PLEK2 CSF3R

2.40e-05190134607215e8f292cb54c670037aaf28393cddbe5548c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B MAP3K20 ACTN1 ABCC8 TMEM131L COL14A1

2.40e-051901346f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-fibroblast|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FN1 ADGRB2 FZD1 PTPRF PTPRS COL14A1

2.47e-0519113469214655dca96d766737c9f30b624d7fe7050342e
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

FN1 MAP3K20 SVEP1 PTPRD PTPRS INMT

2.47e-051911346e7c605b56934d1383237c1f946dbccef25d91368
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-Macrophages|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNFAIP8L2 PSAP LILRB2 TLR7 CD163 CSF3R

2.47e-05191134694c7da03e5264f4d73bb507ce339a935d90279a0
ToppCellControl-Myeloid-MoAM3,_VCAN|Control / Condition, Lineage and Cell class

PSAP FN1 FBN2 CSF3R SERINC5 FZD2

2.47e-05191134676c2fbc62855a65600cd6b8dd1e2d2c3d7415921
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FN1 SVEP1 CSF3R PTPRS INMT TTC39A

2.47e-051911346f00d6824bd138b192a996e9f7de57b235bb24c18
ComputationalGenes in the cancer module 27.

EPHB2 PRSS12 LILRB2 ADGRB2 GRM2 TNFRSF21 ITGB5 CD163 PTPRF CSF3R PTPRS FZD2

2.99e-053558812MODULE_27
DrugTrimethoprim [738-70-5]; Up 200; 13.8uM; PC3; HT_HG-U133A

EPHB2 METTL3 PRSS12 ITGB5 PTPN12 ZFYVE9 SND1 RRN3 TSTD2

2.11e-0619513297377_UP
Drug3-Acetylcoumarin [3949-36-8]; Up 200; 21.2uM; MCF7; HT_HG-U133A

PRSS12 ADAM8 SVEP1 KLHL22 LIMK1 OVGP1 MEGF8 ABCC8 TTC39A

2.30e-0619713293382_UP
DrugOxytetracycline dihydrate [6153-64-6]; Up 200; 8uM; HL60; HG-U133A

EPHB2 RANBP2 PDE3B FN1 NTRK3 ITGB5 OVGP1 LPP MED12

2.39e-0619813291553_UP
DrugMetixene hydrochloride [1553-34-0]; Up 200; 11.6uM; MCF7; HT_HG-U133A

ADAM8 SIRT4 SVEP1 KLHL22 OVGP1 ABCC8 CPSF1 TTC39A

1.67e-0519213283313_UP
DrugMinaprine dihydrochloride [25953-17-7]; Up 200; 10.8uM; HL60; HG-U133A

EPHB2 ZNF410 FN1 LILRB2 TNFRSF21 OVGP1 SND1 SNTB1

1.94e-0519613281968_UP
DrugDeoxycorticosterone [64-85-7]; Down 200; 12.2uM; PC3; HT_HG-U133A

ADAM8 EML3 FZD1 FZD8 LIMK1 LIMK2 PTPRF SND1

2.01e-0519713286758_DN
DrugEvoxine [522-11-2]; Up 200; 11.6uM; PC3; HT_HG-U133A

GRM2 SEMA4C FZD1 PTPRD CPSF1 COL14A1 TTC39A ATP2B2

2.01e-0519713283681_UP
DrugKanamycin A sulfate [25389-94-0]; Up 200; 6.8uM; MCF7; HT_HG-U133A

EPHB2 SIPA1 ADAM8 CD163 KLHL22 SCARF1 BHMT2 COL14A1

2.16e-0519913285686_UP
DrugMefloquine hydrochloride [51773-92-3]; Down 200; 9.6uM; HL60; HG-U133A

RANBP2 ACTN1 TNFRSF21 EML3 OVGP1 ZFYVE9 MTF1 MED12

2.16e-0519913281364_DN
DrugFenspiride hydrochloride [5053-08-7]; Up 200; 13.4uM; PC3; HT_HG-U133A

LILRB2 ITGB5 SVEP1 CD163 KLHL22 LIMK2 OVGP1 COL14A1

2.16e-0519913287298_UP
DrugProxyphylline [603-00-9]; Up 200; 16.8uM; PC3; HT_HG-U133A

EPHB2 ADAM8 FZD7 LIMK1 ZFYVE9 PTPRS LPP SPINK5

2.16e-0519913287290_UP
Diseaseplatelet measurement

KALRN ACTN4 ACTN1 ITGB5 SVEP1 PTPRF TMEM131L FZD2 FBXO34

1.14e-053151309EFO_0005036
DiseaseCFHR5 DEFICIENCY

CFHR1 CFHR5

1.93e-0521302C3553720
Diseaseperinatal necrotizing enterocolitis (biomarker_via_orthology)

TLR7 CD40LG MUC2

5.43e-05171303DOID:8677 (biomarker_via_orthology)
Diseasecortical surface area measurement

MAGI1 NCAPD3 PRSS12 ACTN4 ACTRT2 CLSTN1 ITGB5 SVEP1 FBN2 PTPRF SND1 ADAMTS7 ADAMTS18 L3MBTL3 ARHGAP21 SNTB1 ANKS1A

8.95e-05134513017EFO_0010736
Diseasecortical thickness

MAGI1 PRSS12 ACTN4 ACTRT2 ITGB5 FBN2 PTPRF SND1 ADAMTS7 CSK PCDHGB4 ADAMTS18 ARHGAP21 SNTB1 ANKS1A

1.19e-04111313015EFO_0004840
Diseaseaortic measurement

KALRN ACTN4 LIMK1 ADAMTS7 ABCC8 ARID5B ADAMTS18

1.29e-042511307EFO_0020865
Diseasefocal segmental glomerulosclerosis 1 (implicated_via_orthology)

ACTN4 ACTN1

1.91e-0451302DOID:0111128 (implicated_via_orthology)
Diseaseazoospermia (implicated_via_orthology)

PTPRD PTPRF PTPRS

2.26e-04271303DOID:14227 (implicated_via_orthology)
Diseasewaist-hip ratio

EPHB2 FN1 ACTRT2 SIPA1 PTPRD MEGF8 CSK PTPRS ABCC8 ARID5B COL14A1 TTC39A L3MBTL3 ARHGAP21 SNTB1

3.37e-04122613015EFO_0004343
DiseaseComplement deficiency disease

CFHR1 CFHR5 MASP2

4.14e-04331303C0272242
Diseaseacute myeloid leukemia (is_implicated_in)

CFHR1 GPX1 CSF3R LPP

5.28e-04841304DOID:9119 (is_implicated_in)
DiseaseC3 glomerulopathy

CFHR1 CFHR5

6.80e-0491302C4087273
Diseasereticulocyte measurement

PDE3B GPX1 ACTN4 SIPA1 SCARF1 PLEK2 PCDHGB4 TMEM131L ASXL2 L3MBTL3 ARHGAP21 MED12 FBXO34

7.85e-04105313013EFO_0010700
DiseaseDisease Exacerbation

ABCA13 WDR46 CLCN3 PTPRF CPSF1

8.39e-041651305C0235874
Diseasevesicular integral-membrane protein VIP36 measurement

KALRN ITGB5

8.47e-04101302EFO_0022012
Diseasedisposition index measurement, glucose homeostasis measurement

SOHLH2 INMT

8.47e-04101302EFO_0006832, EFO_0006896
Diseasehemopexin measurement

CFHR1 CFHR5

1.03e-03111302EFO_0008149
DiseaseLeukemia, Myelocytic, Acute

NTRK3 FANCM CSF3R LPP ASXL2

1.04e-031731305C0023467
DiseaseColorectal Carcinoma

FN1 KALRN ABCA13 OVGP1 FBN2 PTPRD PTPRS ABCC8 ADAMTS18 C2CD6

1.12e-0370213010C0009402
Diseasediabetic angiopathy (is_marker_for)

GPX1 CD40LG

1.24e-03121302DOID:11713 (is_marker_for)
Diseasehyperinsulinism (is_implicated_in)

PTPRF ABCC8

1.24e-03121302DOID:2018 (is_implicated_in)
Diseasecomplement factor H-related protein 4 measurement

TPO CFHR1 CFHR5

1.33e-03491303EFO_0600091
Diseaseiron deficiency anemia (biomarker_via_orthology)

FN1 GPX1

1.46e-03131302DOID:11758 (biomarker_via_orthology)
DiseaseOpioid use measurement

PTPRD SNTB1

1.95e-03151302EFO_0009937
DiseaseWilliams-Beuren syndrome (implicated_via_orthology)

LIMK1 LIMK2

1.95e-03151302DOID:1928 (implicated_via_orthology)
Disease1,3,7-trimethylurate measurement

PTPRF ARID5B

1.95e-03151302EFO_0021172
Diseasetumor necrosis factor beta measurement

EPHB2 SNTB1

1.95e-03151302EFO_0008308
Diseaseurate measurement, spine bone mineral density

RBM20 PTPRD SNX9

2.16e-03581303EFO_0004531, EFO_0007701
Diseaseresponse to antineoplastic agent, response to antimicrotubule agent

ADAMTS18 TMEM131L

2.22e-03161302EFO_0005260, GO_0097327
Diseasemultiple myeloma (is_implicated_in)

CFHR1 GPX1 CD40LG

2.27e-03591303DOID:9538 (is_implicated_in)
Diseasereticulocyte count

PDE3B GPX1 ACTN1 SIPA1 SCARF1 PLEK2 PCDHGB4 TMEM131L ASXL2 L3MBTL3 MED12 FBXO34

2.29e-03104513012EFO_0007986
Diseaseatrophic macular degeneration, age-related macular degeneration, wet macular degeneration

CFHR1 CFHR5 ARHGAP21

2.38e-03601303EFO_0001365, EFO_0004683, EFO_1001492
Diseasethyroxine measurement, triiodothyronine measurement

EPHB2 TIAM2

2.51e-03171302EFO_0005130, EFO_0008392
Diseasepartial epilepsy

FZD7 PTPRD

2.51e-03171302EFO_0004263
Diseasenon-Hodgkin lymphoma (is_implicated_in)

GPX1 TMEM260

2.51e-03171302DOID:0060060 (is_implicated_in)
Diseasecystic fibrosis (is_marker_for)

CSF3R CD40LG MUC2

2.61e-03621303DOID:1485 (is_marker_for)
Diseasesystemic lupus erythematosus

TLR7 SIPA1 LIMK1 FBN2 CSK MTF1 LPP ARID5B L3MBTL3 ANKS1A

2.89e-0379913010MONDO_0007915
DiseaseCoronary Arteriosclerosis

ADAMTS7 CD40LG ANKS1A

2.99e-03651303C0010054
DiseaseCoronary Artery Disease

ADAMTS7 CD40LG ANKS1A

2.99e-03651303C1956346
Diseaseglomerulonephritis (is_marker_for)

FN1 CD163

3.14e-03191302DOID:2921 (is_marker_for)
Diseasepulse pressure measurement

FN1 ACTN4 SIPA1 ITGB5 SVEP1 LIMK1 FBN2 PTPRD DAZAP1 MEGF8 SND1 MTF1 LPP FZD2

3.37e-03139213014EFO_0005763
Diseaseascending aortic diameter

LIMK1 FBN2 ABCC8 ARID5B

3.48e-031401304EFO_0021787
DiseaseMalignant Glioma

NTRK3 APOD CLCN3

3.69e-03701303C0555198
Diseasemixed gliomas

NTRK3 APOD CLCN3

3.69e-03701303C0259783
Diseasethyroid peroxidase antibody measurement

TPO KALRN TMEM131L

3.99e-03721303EFO_0005666
Diseasestomach cancer (is_implicated_in)

NTRK3 GPX1 TMEM260

3.99e-03721303DOID:10534 (is_implicated_in)
DiseaseAutosomal Recessive Primary Microcephaly

NCAPD3 COPB2

4.20e-03221302C3711387

Protein segments in the cluster

PeptideGeneStartEntry
HGGKACEGPELQTKL

ADGRB2

396

O60241
GAAEGQAFHLGKCPN

APOD

16

P05090
DHSGTLGPEEFKACL

ACTN1

761

P12814
KPCGQQSIHLGGVFE

CD40LG

216

P29965
GHTFPCQLDKGLVDD

ACTRT2

201

Q8TDY3
SPNFTLEGHEKGVNC

COPB2

176

P35606
SVQEHVELLGCGAGP

CARMIL2

736

Q6F5E8
LFEKCEVNGAGAHPL

GPX1

111

P07203
GLFPVHQKGGPAEDC

GRM2

36

Q14416
KGDSGGPLICKGVFH

GZMK

211

P49863
SQKGFPGCKLGLHDN

FBXO34

671

Q9NWN3
HGGALGPEEFKACLI

ACTN4

781

O43707
CLGSPQHIKNRFGDG

ABCA13

4936

Q86UQ4
HGTAEQDLPFCKGDV

CSK

21

P41240
GPAHCVGEIVTKFGS

ECT2L

641

Q008S8
GLLHGSSPVCEVGQD

ANKS1A

501

Q92625
EGEICGFKIHGQNVP

CLSTN1

81

O94985
ECHVFIGGTPLSQDK

DDX20

161

Q9UHI6
DLSHLVGGPVCGNLF

ADAM8

401

P78325
PFEIQGIAGCELHSG

CD1B

111

P29016
FVGGIPHNCGETELR

DAZAP1

116

Q96EP5
GIIHPGEDFLCLEGK

ATP2B2

746

Q01814
PVHCAADGTVELKAG

ASXL2

846

Q76L83
HDGEGNPCRKAEGNI

ADAMTS18

446

Q8TE60
QCVKFGELGPRPIHG

ADAMTS18

576

Q8TE60
IQHDGSGNDCEPVGK

ADAMTS7

396

Q9UKP4
EVVAFFGQHCPITGG

ESRP1

341

Q6NXG1
FGQHCPITGGKEGIL

ESRP1

346

Q6NXG1
VIPDFVCQGGDITKH

RANBP2

3116

P49792
HVASGFPAEQAGGLK

RBM20

291

Q5T481
DPKICFGDGDGTVNL

PLA2G15

351

Q8NCC3
TAATEGQKCVPGHFG

RASEF

661

Q8IZ41
HNGEVTCKLEGDVPF

PCDHGB4

376

Q9UN71
QEQVHPKTGCERGDG

PAGE1

106

O75459
FIQSLPGCEEHGKVF

L3MBTL3

716

Q96JM7
GEGKGPIHVDNVKCT

PRSS12

556

P56730
HECTVKRGPQGELGV

MAGI1

16

Q96QZ7
GEISEGCLLFNKPTH

NTRK3

356

Q16288
NLECLHKTFGPGGLQ

INMT

41

O95050
GEEGCHQNGLALPVV

GPBP1L1

361

Q9HC44
FRPCDLIHGEVLGKG

LIMK2

326

P53671
DPIQGPDGKVHGNTC

SPINK5

386

Q9NQ38
DPIEGLDGKIHGNTC

SPINK5

586

Q9NQ38
TVPEKIGVFCDFDGG

FSD1L

446

Q9BXM9
GHTVPLSDGGKAFCI

KCNK1

121

O00180
LPQEGKGTCILVGGH

FANCM

1811

Q8IYD8
VPFGDVVGCLGIHIK

C2CD6

101

Q53TS8
PDLEIVVCSGHGKNG

CPSF1

496

Q10570
EFGEVCSGHLKLPGK

EPHB2

631

P29323
EICGPNGTVEKHFNI

MUC2

1241

Q02817
GKRPHQEFGISSQGC

PDE3B

461

Q13370
ETGGGTPELRCGKHQ

TPO

886

P07202
HGEKGISIPDHGFCQ

FZD2

26

Q14332
LGVTEHVEGDPCKFA

KALRN

1531

O60229
KCRESFHGSPLGGQQ

MEGF8

2426

Q7Z7M0
PRLCHIVKDEGGFGF

PDZD3

221

Q86UT5
GIPFTVDAGGLIHCI

LPP

511

Q93052
GGFILCKEGEDEHPQ

LILRB2

151

Q8N423
CNRIFGLGPSKDGHE

MED12

481

Q93074
LIGNESKGEHVPGFC

GCN1

2241

Q92616
DGKLGGLVQPHDGQC

ITGB5

286

P18084
EHCLVGVKGNPQGFN

METTL3

481

Q86U44
TKEQFGQDGPISVHC

PTPRS

1866

Q13332
EKFPVHGAGELCVGQ

FZD1

216

Q9UP38
HGEKGISVPDHGFCQ

FZD7

36

O75084
FPVHGAGEICVGQNT

FZD7

151

O75084
LVAGHEKVACSGGAP

FZD8

331

Q9H461
DFQCVVGFGGIHSTP

KLHL22

296

Q53GT1
GFHAPDCGKEGFVDL

BHMT2

241

Q9H2M3
PFEVQVKAGCELHSG

CD1C

111

P29017
VKAGCELHSGKSPEG

CD1C

116

P29017
VGKISFCPKDVLGHG

ERN1

566

O75460
FCPKDVLGHGAEGTI

ERN1

571

O75460
GNGKGEFKCDPHEAT

FN1

2371

P02751
TCPVVHKDGIDLAGF

COL14A1

1216

Q05707
GDSILDCVPKDGQSH

CSF3R

171

Q99062
VGGEGTLCDFPKIHH

CFHR5

16

Q9BXR6
VFGFHLKPGTGPQDC

MAP3K20

441

Q9NYL2
LKIQTDREEHGPFCG

MASP2

246

O00187
DLKETGLCADFHPSG

EML3

636

Q32P44
GEGAFGKVVECIDHG

CLK4

166

Q9HAZ1
KGKQFDAQGHCLPDG

FAM135B

851

Q49AJ0
CGNIPGFTFDIHTGK

FBN2

1791

P35556
VGGEATFCDFPKINH

CFHR1

16

Q03591
VLGHAGKESCPVIFG

HELZ2

2456

Q9BYK8
VGGDIPCSGRVEVKH

CD163

481

Q86VB7
KEQFGQDGPITVHCS

PTPRF

1826

P10586
PGGEAGVTEIHGKCE

OVGP1

426

Q12889
KEQFGQDGPISVHCS

PTPRD

1831

P23468
PGELAHLCKDVDGLG

FAM181A

311

Q8N9Y4
LFHCVLGPGGAAAEV

ITPRIPL2

451

Q3MIP1
EHSLVPGCLDGGGVQ

RTP5

31

Q14D33
DSGTKAFCDVALHGP

RRN3

441

Q9NYV6
GCFPDIIGTHKGAIE

SNX9

501

Q9Y5X1
FGGKDGEIQLDLHSC

SNTB1

501

Q13884
CPVGTFTRHENGIEK

TNFRSF21

91

O75509
PTKEGSLGFEVIAHC

TMEM131L

491

A2VDJ0
QCGEHLPFLVGGEEG

MTF1

66

Q14872
LITSENEKCDHPAGG

PTPN12

716

Q05209
LQDITEGGGHCPVHL

SHOX

56

O15266
SDLLHGAPGFVCELG

SIPA1

156

Q96FS4
VQCGGHLKPDVVFFG

SIRT4

221

Q9Y6E7
GCPHVTLQFADSKGD

SND1

836

Q7KZF4
GSFKPERVGVCTLHG

CCT8L1P

196

A6NM43
TLEHGEFEDGKGKCP

SEMA4C

146

Q9C0C4
EGFLLQGHGIITCNP

SVEP1

3386

Q4LDE5
GTQGSELDPKGQHVC

SCARF1

16

Q14162
FLHNKEGCPLDVTGT

SV2A

576

Q7L0J3
GPLCIFGIVDHLGKE

ABCC8

316

Q09428
RCGFHAGPVKTEALG

ARID5B

121

Q14865
SPIHGEGDKVISCVF

NCAPD3

286

P42695
GLSLGKEGPLVHVAC

CLCN3

276

P51790
CPTGGNFLEEKSILG

ZNF132

266

P52740
AFEITGAIHAGQPGK

PLEK2

96

Q9NYT0
GPDFTQHLGKICDGL

TNFAIP8L2

161

Q6P589
VGSFLNVHEGPCGIS

XPNPEP1

491

Q9NQW7
GCLRVEFHNGGNPSK

TIAM2

171

Q8IVF5
GGEQPKLVRGHFCPI

TIAM2

1621

Q8IVF5
GPGAILCSKHFQESD

THAP9

56

Q9H5L6
GPGECTLDHGSKLFF

TONSL

1361

Q96HA7
KGGECHAPKGTRDTQ

RNF25

356

Q96BH1
RIHTGEKPFLCEAQG

ZNF410

301

Q86VK4
HGKNVTICVPDFGQD

SERINC5

291

Q86VE9
DSGTKAFCDVALHGP

RRN3P1

66

Q2M238
HGQKGVCGLIVPQED

POLR3B

901

Q9NW08
KGGAHCFPELRVGVF

TSTD2

246

Q5T7W7
LTVHVTQPKDGGFCE

PSAP

396

P07602
DVTCVGPGAHKGQSV

TLR7

811

Q9NYK1
HGLQFCPFEDVLGVG

WDR46

451

O15213
PEGNSCKFAHGNAEL

ZC3H7A

916

Q8IWR0
IHGEEGLFSLGCVKN

TRIM49D1

371

C9J1S8
IGHGCNEGEKILSAG

ZNF594

81

Q96JF6
TVDGIGALPGCHTGK

TRAPPC8

851

Q9Y2L5
FIIPENFKGCISGHG

SOHLH2

101

Q9NX45
QVKEGGPAFEAGLCT

ARHGAP21

106

Q5T5U3
IDGKIFCVHGGLSPS

PPP4C

156

P60510
CKGENHPHFEGGVKL

TTC39A

211

Q5SRH9
AGIPTVLQGHIDCGS

SERINC2

76

Q96SA4
LVPVIHGGACQLSEG

ZFYVE9

1396

O95405
LHGCQPGSVSVDKKG

TRIM56

676

Q9BRZ2
QKETFVCIGIHEGDP

TMEM260

516

Q9NX78
PSDLIHGEVLGKGCF

LIMK1

336

P53667