Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentacrosomal membrane

TRIP11 CAV2

5.40e-0438192GO:0002080
GeneOntologyCellularComponenttransport vesicle

APBA1 TRIP11 CAV2 APP

1.08e-03519194GO:0030133
MousePhenodecreased corpus callosum size

NIPBL ZIC2 APP

1.58e-0547153MP:0000781
MousePhenoabnormal corpus callosum size

NIPBL ZIC2 APP

2.14e-0552153MP:0020573
MousePhenohematoma

ZIC2 APP

2.93e-0424152MP:0008817
MousePhenoabnormal corpus callosum morphology

NIPBL ZIC2 APP

3.22e-04129153MP:0000780
MousePhenoabnormal dorsal telencephalic commissure morphology

NIPBL ZIC2 APP

3.45e-04132153MP:0008219
MousePhenoabnormal skeletal muscle fiber size

FZD4 CAV2 APP

4.10e-04140153MP:0009398
DomainZnf_C2H2-like

RBM6 ZNF426 ZNF587B ZIC2

7.61e-03796194IPR015880
DomainZnF_C2H2

RBM6 ZNF426 ZNF587B ZIC2

8.01e-03808194SM00355
DomainPDZ

APBA1 PDZRN4

8.90e-03141192PF00595
DomainPDZ

APBA1 PDZRN4

9.76e-03148192SM00228
Domain-

APBA1 PDZRN4

1.00e-021501922.30.42.10
DomainPDZ

APBA1 PDZRN4

1.01e-02151192PS50106
DomainPDZ

APBA1 PDZRN4

1.03e-02152192IPR001478
Pubmed

X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence.

APBA1 APP

2.83e-07219212849748
Pubmed

Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing.

APBA1 APP

2.83e-07219222355143
Pubmed

Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11alpha.

APBA1 APP

8.48e-07319216458391
Pubmed

Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein.

APBA1 APP

8.48e-07319214970211
Pubmed

Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism.

APBA1 APP

8.48e-07319212016213
Pubmed

RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing.

APBA1 APP

8.48e-07319215699037
Pubmed

X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains.

APBA1 APP

1.70e-06419211083918
Pubmed

X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.

APBA1 APP

1.70e-06419218845544
Pubmed

Novel mediators of amyloid precursor protein signaling.

APBA1 APP

1.70e-06419220016085
Pubmed

X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.

APBA1 APP

1.70e-06419214756819
Pubmed

Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid β generation.

APBA1 APP

1.70e-06419224742670
Pubmed

Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production.

APBA1 APP

1.70e-06419217428983
Pubmed

Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling.

FZD4 APP

1.70e-06419218234671
Pubmed

Interrogation and validation of the interactome of neuronal Munc18-interacting Mint proteins with AlphaFold2.

APBA1 APP

4.24e-06619238072052
Pubmed

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.

APBA1 APP

4.24e-0661928887653
Pubmed

Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms.

APBA1 APP

4.24e-06619212196555
Pubmed

Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.

FZD4 PDZRN4

1.06e-042819222808246
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

APBA1 NFE2L3 TRIP11 NIPBL APP

5.15e-04128519535914814
GeneFamilyPDZ domain containing

APBA1 PDZRN4

3.02e-031521021220
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF426 ZNF587B ZIC2

6.07e-0371810328
CoexpressionAtlasMyeloid Cells, MF.II-480hi.PC, F4/80hi CD115hi CD11b+ MHC II- CD11c-, Peritoneal Cavity, avg-3

FZD4 GSR CAV2 SMPDL3B APP

3.34e-05438195GSM605850_500
ToppCell390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|390C / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

5.09e-05172193fd8097299fc05390b30afaa9e6c80b1f607c27aa
ToppCell390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|390C / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

5.09e-051721936f302ed795767a9636081dc64373f8f039ea16d2
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CAV2 SMPDL3B PDZRN4

5.35e-0517519390e29945aa861082c94bb4f331161adc3a6ef899
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CAV2 SMPDL3B PDZRN4

5.45e-05176193e4b21fd6a5e0c5950f27c3e1868318e48330ae5e
ToppCell356C-Endothelial_cells-Endothelial-D|356C / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

5.54e-05177193a0b172f40e0df97a288a5549ae7066697ad469b3
ToppCell356C-Endothelial_cells-Endothelial-D-|356C / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

5.54e-05177193ab8f09e118e4df696b0b4d33f013da020bdbd351
ToppCell390C-Endothelial_cells-Endothelial-E|390C / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

5.63e-05178193ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCell390C-Endothelial_cells-Endothelial-E-|390C / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

5.63e-05178193804ac3725c1f88e2212172bfb9aa01d97a735621
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CAV2 SMPDL3B PDZRN4

5.73e-051791937954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|367C / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

5.82e-05180193162cec1734e560c068cd61717e40e18dcf92308c
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|367C / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

5.82e-0518019333c86c22ba877358cd8c1e39b5c0b3dc3a45b7dd
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CAV2 SMPDL3B PDZRN4

5.82e-05180193b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCellfacs-Thymus-Epithelium-3m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

5.92e-05181193bce56e12ab93693c9c04fa6aad8f2e1dff0c4d45
ToppCellfacs-Kidney-nan-3m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

6.02e-051821934c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCellCOPD-Endothelial-VE_Capillary_A|COPD / Disease state, Lineage and Cell class

FZD4 CAV2 APP

6.21e-051841935f4f7775d488ececf086c71441defecbee9d8a9c
ToppCelldroplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 TRIP11 CAV2

6.31e-0518519360206c7322b4ddb2010040aac70561df842c9843
ToppCellControl-Endothelial-VE_Capillary_A|World / Disease state, Lineage and Cell class

FZD4 CAV2 APP

6.31e-05185193a28187c2fd23564314b35759479ff2ca21f61485
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FZD4 CAV2 APP

6.52e-0518719397b2463fb37e7196dd2f92553acf8e7bc3ec40dd
ToppCellControl-Endothelial-VE_Capillary_A|Control / Disease state, Lineage and Cell class

FZD4 CAV2 APP

6.52e-0518719354d7588172ac145ff5045ad9771636729ca3f0ca
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|343B / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

6.62e-05188193fe7143c36e4a883745862d3c3147cf751b440e46
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|343B / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

6.62e-05188193cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCellIPF-Endothelial-VE_Capillary_A|World / Disease state, Lineage and Cell class

FZD4 CAV2 APP

6.73e-05189193ea3aa3ef38f1d405bb527ae383cd12c551a3dd6f
ToppCellLAM-Endothelial-VasEndo-1|LAM / Condition, Lineage and Cell class

FZD4 CAV2 APP

6.73e-05189193454e64b1ee93edebbc1576fbf7c3a6db332fa927
ToppCellfacs-Thymus-Epithelium-3m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

6.94e-051911936676ef9aeb890668cb69e67865404061b8467c25
ToppCellfacs-Thymus-Epithelium-3m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

6.94e-05191193a157cee0fbc9dce64308128c3578e7327fa178b7
ToppCellfacs-Thymus-Epithelium-3m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

6.94e-05191193d2311a5b0cf186839000f9f272b6fbc2270ddb44
ToppCellfacs-Thymus-Epithelium-24m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

7.05e-05192193597db951b1fbc37db22134c3d27d3ec4ceaa85f7
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

7.05e-051921934bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCellfacs-Thymus-Epithelium-24m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

7.05e-0519219339afea574725ce0c67afdd79facdb34f819a828d
ToppCellfacs-Thymus-Epithelium-24m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

7.05e-05192193bc275a9eccb1c7a46fd58b15ca5acdd9f7495842
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FZD4 CAV2 APP

7.16e-05193193aaf681f16f310168e4719464814a1fc0a2f8431a
ToppCellCOPD-Endothelial|COPD / Disease state, Lineage and Cell class

FZD4 CAV2 APP

7.16e-05193193093b28dcccb5841c995d0b33fae0efd6b88f97e0
ToppCell(6)_Endothelial-C_(Capillary_Aerocyte_)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

FZD4 CAV2 APP

7.16e-05193193f7f2dc6aff02d096a282835094d26d12b3b73e61
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

7.27e-05194193f159ef8541d75a4e98468947f231bb463bec922c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FZD4 ZIC2 APP

7.27e-05194193ea5e1bc8d9e27cabfe1fb833ca47ec0893593b12
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FZD4 ZIC2 APP

7.27e-05194193cceb7c88492bb6cd531e1c2651638da1ddf30931
ToppCellfacs-Thymus-Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

7.27e-05194193255d6eead8da740a942a5e7d554dbd895d736d1a
ToppCellLAM-Endothelial|LAM / Condition, Lineage and Cell class

FZD4 CAV2 APP

7.27e-051941931241e3e75414b619abc9431627619f5c194ec930
ToppCellfacs-Aorta-Heart-3m-Endothelial|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

7.38e-051951938493f2f60fc356af28b9c0e287d4cd8c8899c081
ToppCellfacs-Lung-nan-3m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

7.38e-051951937f9b7f15006610ad591063d90e90367bd6083c7f
ToppCellfacs-Aorta-Heart-3m-Endothelial-aortic_endothelial_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

7.38e-051951935e5ca7bd94c9e924ed76f7ccac199be745d4c4eb
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FZD4 CAV2 APP

7.49e-05196193a53caedd0103bd162b3aee8ab87b4442a5e0338f
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-sinusoidal_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FZD4 CAV2 APP

7.61e-05197193f1080d93acf1a4756d2f2c8cabd1fb50bc7bcd09
ToppCell390C-Endothelial_cells|390C / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

7.61e-05197193aa381acea0f7882d39435a6f713386bf0588b5f8
ToppCelltumor_Lung-Endothelial_cells|tumor_Lung / Location, Cell class and cell subclass

FZD4 CAV2 APP

7.61e-051971936870b311c54a73723768276a58456620f5217d43
ToppCell356C-Endothelial_cells|356C / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

7.61e-05197193f20eda534b2b28986790b28ce150ca3ba067593a
ToppCellfacs-Heart-RV-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD4 CAV2 APP

7.61e-05197193a2d9d3098e5103290b434919dbbc40d7e79fcae0
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FZD4 CAV2 APP

7.61e-0519719386591849476b3925857a82b6913f65e74df200c1
ToppCell3'-Child09-12-SmallIntestine-Endothelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FZD4 CAV2 APP

7.61e-0519719386a02fd7b4762b3278e5e60b5483b5fc1206e597
ToppCelltumor_Lung-Endothelial_cells-Tip-like_ECs|tumor_Lung / Location, Cell class and cell subclass

FZD4 CAV2 APP

7.61e-05197193353b76ca3e2aa4b8f51396e7121c4baa114083a0
ToppCell5'-Adult-LymphNode-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FZD4 CAV2 APP

7.72e-05198193d7e15e61b6018e4c36461c9471ee29601929925c
ToppCelltumor_Lung-Endothelial_cells-Tumor_ECs|tumor_Lung / Location, Cell class and cell subclass

FZD4 CAV2 APP

7.72e-051981935228c4bf2513186140c2c4eaa67a268c732bdc84
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FZD4 CAV2 APP

7.72e-051981939ecf944984aade1bf902e3a92ea4d46a3696822f
ToppCell3'-Child04-06-SmallIntestine-Endothelial|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FZD4 CAV2 APP

7.72e-05198193bf4e086c3fc924e999b6eaca87d2beee9b9526c2
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FZD4 CAV2 APP

7.72e-051981935b86dc00acf8ac2ede008f5d79c09996485bf250
ToppCell(6)_Endothelial-A_(Artery)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

FZD4 CAV2 APP

7.72e-0519819344f8cd5afa3685dcc8bfea0b15af5e8817e12e2e
ToppCelldistal-1-Endothelial-Vein|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FZD4 CAV2 PDZRN4

7.72e-05198193eee6cb4fe0e1caf460869d5a0a57c9d259573f10
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FZD4 CAV2 APP

7.72e-0519819313203249e5743ba2699871c184d141207e550a86
ToppCell3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FZD4 CAV2 APP

7.72e-0519819399be7a7a84199dac598e993a5a0144d9030f13ce
ToppCellILEUM-inflamed-(7)_CD36+_endothelial_cells|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FZD4 CAV2 APP

7.72e-0519819305d6558c7990ad2277db999025a073d29b273dfc
ToppCell(6)_Endothelial-E|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

FZD4 CAV2 APP

7.72e-05198193a5e1b321376caf262ea48904d31afd1b8e9d3be2
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FZD4 CAV2 APP

7.72e-05198193e9e98c20ff7b3f3851db86381550ce7085e2db9e
ToppCell(6)_Endothelial_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

FZD4 CAV2 APP

7.72e-05198193f38f49d532fa6211f57e36ee494478bdd3f4f89c
ToppCell343B-Endothelial_cells|343B / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

7.72e-05198193fab32347580c7a81ef1fe4fe7b325d9105a947d9
ToppCell10x3'2.3-week_14-16-Endothelial|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FZD4 CAV2 APP

7.84e-0519919341f046646fff65b7e51b63d3204f76ef32054781
ToppCellfacs-Lung-18m|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FZD4 CAV2 APP

7.84e-05199193c11e0044d3cc37f6bb26df033ad4448b419addfc
ToppCellcellseq-Endothelial|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FZD4 CAV2 APP

7.84e-051991934757827efb393c429adec5079d18a173baf23d74
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FZD4 ZIC2 CAV2

7.84e-05199193236b1417ed0875e98c6ec1ec714003bfce438d65
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FZD4 CAV2 APP

7.84e-051991931c69395c9305b6ecb0a826d46c8e8ec95795ad6d
ToppCellcellseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FZD4 CAV2 APP

7.84e-051991939364199c5b4540ce2e14341fd9d504b695f8249d
ToppCelldistal-2-Endothelial-Capillary_Aerocyte|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FZD4 CAV2 APP

7.84e-05199193bf70c8bfe932bccac5014e55f82019c5148627e7
ToppCellmedial-2-Endothelial-Capillary_Aerocyte|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FZD4 CAV2 APP

7.84e-05199193c5048b31649a0b7eddcd481b0458ed96508f5561
ToppCell367C-Endothelial_cells|367C / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

7.84e-05199193636ff80938907f137e955388797072ab45289062
ToppCell343B-Endothelial_cells-Endothelial-E-|343B / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

7.84e-05199193bff61a784ef8bc040f5c7baabccaf7a7cddd5a31
ToppCellcellseq-Endothelial-Endothelial_Vascular-Endothelial_capillary|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FZD4 CAV2 APP

7.84e-051991935f67ea58512856cbdcef759088a5869720a947a8
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FZD4 CAV2 APP

7.84e-0519919382758d0cee9387d002e3f68a6faa324134fb7564
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

FZD4 CAV2 APP

7.84e-051991931621ce2968f3100e4c39e0ef8293232a5d76c614
ToppCell343B-Endothelial_cells-Endothelial-E|343B / Donor, Lineage, Cell class and subclass (all cells)

FZD4 CAV2 APP

7.84e-051991933cb1d9d9de64ed0a56c4f8d5e2fa02a13a73d8ac
ToppCell3'-Parenchyma_lung-Endothelial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FZD4 CAV2 APP

7.84e-05199193920299626a9ec8e50d944f5a7667e855de7edd72
ToppCell5'-Parenchyma_lung-Endothelial|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FZD4 CAV2 APP

7.84e-05199193c0a1ed48bebcd85cbbffb8ac50fb0f902b97f239
ToppCell3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FZD4 CAV2 APP

7.84e-0519919357709dc893da8d9333830b8277a6d92e25aa8bc0
ToppCellmedial-Endothelial-Capillary_Aerocyte|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FZD4 CAV2 APP

7.84e-0519919384e30c39c2f050aa64af167999824c1cba32ba05
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FZD4 CAV2 APP

7.84e-05199193d66514bdffdd96468b543ec96041e42c12472e66
ToppCellcellseq-Endothelial-Endothelial_Vascular|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FZD4 CAV2 APP

7.84e-05199193307d29816a224193aa3d8c4540e128b2ad2e90b9
ToppCellILEUM-inflamed-(7)_Endothelial_cell|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FZD4 CAV2 APP

7.84e-0519919397052c28e354833901f28d339b09f97f50a5b752
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FZD4 CAV2 APP

7.84e-0519919314a7c4cf4bb3d43fd32ec9cc74f6625b225ffaa1
ToppCellmedial-Endothelial-Capillary_Aerocyte-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FZD4 CAV2 APP

7.84e-05199193f1039d1ab498fc58f0feba545df05833c235db74
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FZD4 CAV2 APP

7.84e-051991936cfe5a3d0ad530411ebc11decb4ab4c529e018d5
ToppCell10x3'2.3-week_14-16-Endothelial-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FZD4 CAV2 APP

7.84e-05199193ef7f7f7c861827574b120f48cf4052c563929081
ToppCelldistal-Endothelial-Capillary_Aerocyte-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FZD4 CAV2 APP

7.84e-051991939021f4be004efd51bb3658e5bbff53589356b3df
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO-|Neuronal / cells hierarchy compared to all cells using T-Statistic

CAV2 SMPDL3B PDZRN4

7.96e-05200193e3051dcf9b5c8e4dc71a8080b7a7aafea46f2b2b
ToppCellmedial-Endothelial-Capillary_Intermediate_1|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FZD4 CAV2 APP

7.96e-052001933ef7b7728615710c691aed8977e2582f19692cf9
ToppCelldistal-1-Endothelial-Capillary_Aerocyte|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FZD4 CAV2 APP

7.96e-0520019359bacd738433cec6d05624a25fdfc087fb3ca3b5
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FZD4 CAV2 APP

7.96e-05200193ec9a18576a3d08ddfceb70d114c4ab861fbb0d08
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

FZD4 CAV2 APP

7.96e-052001933653002c805c314043e2a7b0c9980dfe952dc53e
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO|Neuronal / cells hierarchy compared to all cells using T-Statistic

CAV2 SMPDL3B PDZRN4

7.96e-052001930638273fc0910f47fe7a0b6d9a8639b0e9976d13
ToppCelldistal-Endothelial-Capillary_Intermediate_1-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FZD4 CAV2 APP

7.96e-0520019343bc48413b100a06f8edd9acd812296788fcbf5b
ToppCellcellseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FZD4 CAV2 APP

7.96e-0520019313f6ac0dfc9206dd2e6cbd84357a5883952ee5c7
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FZD4 CAV2 APP

7.96e-052001933767abc75176779198505ebc6967d55ce322d9fe
ToppCelldistal-Endothelial-Capillary_Aerocyte-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FZD4 CAV2 APP

7.96e-052001930656906d16b0df19c0511965b5d18e9eab3cb168
DrugThyroxine

GSR ZIC2 EPC1 APP

6.00e-06147194ctd:D013974
DrugAC1L97SZ

GSR APP

1.38e-057192CID000439670
Drugepoxiconazole

GSR APP

1.84e-058192CID000107901
Drug2,5-dihydroxybenzoic acid

GSR APP

2.37e-059192ctd:C010925
DrugMIBK

APBA1 CAV2 APP

2.60e-0570193CID000007909
Drugpycnogenols

GSR APP

3.61e-0511192ctd:C024070
Drug2w0s

GSR APP

5.97e-0514192CID000447714
DrugIdarubicin

GSR APP

6.88e-0515192ctd:D015255
DrugCoA disulfide

GSR APP

8.91e-0517192CID000169341
DrugAC1MRQ5O

GSR APP

1.24e-0420192CID003496892
DrugScopolamine Hydrobromide

APBA1 GSR APP

1.30e-04120193ctd:D012601
DrugAadp

GSR APP

1.65e-0423192CID000163551
DrugSodium Nitrite

GSR APP

3.02e-0431192ctd:D012977
DrugSyrosingopine [84-36-6]; Up 200; 6uM; HL60; HG-U133A

FZD4 PAFAH1B3 APP

5.10e-041911931761_UP
Drugradicicol; Up 200; 0.1uM; HL60; HG-U133A

FZD4 NIPBL APP

5.26e-04193193544_UP
Druggeldanamycin; Down 200; 1uM; PC3; HT_HG-U133A

TRIP11 SMPDL3B APP

5.26e-041931931228_DN
DrugNocodazole [31430-18-9]; Down 200; 13.2uM; PC3; HT_HG-U133A

TRIP11 NIPBL APP

5.26e-041931932076_DN
DrugTranylcypromine hydrochloride [1986-47-6]; Down 200; 23.6uM; HL60; HG-U133A

GSR PAFAH1B3 APP

5.26e-041931931417_DN
DrugCP-320650-01 [172079-28-6]; Down 200; 1uM; MCF7; HT_HG-U133A

PIGA SMPDL3B APP

5.26e-041931933908_DN
DrugDanazol [17230-88-5]; Down 200; 11.8uM; PC3; HG-U133A

FZD4 NIPBL APP

5.34e-041941931954_DN
Drugcobalt(II) chloride hexahydrate; Up 200; 100uM; MCF7; HG-U133A

TRIP11 PAFAH1B3 PIGA

5.50e-04196193379_UP
DrugPaclitaxel [33069-62-4]; Down 200; 4.6uM; HL60; HG-U133A

NIPBL PAFAH1B3 APP

5.50e-041961932043_DN
DrugAlclometasone dipropionate [667634-13-2]; Down 200; 7.6uM; MCF7; HT_HG-U133A

FZD4 SMPDL3B APP

5.58e-041971936229_DN
DrugPheniramine maleate [132-20-7]; Down 200; 11.2uM; HL60; HG-U133A

GSR PAFAH1B3 APP

5.58e-041971931992_DN
DrugCefaclor [70356-03-5]; Down 200; 10.4uM; MCF7; HT_HG-U133A

TRIP11 SMPDL3B APP

5.66e-041981934967_DN
DrugHydrastine hydrochloride [5936-28-7]; Up 200; 9.6uM; HL60; HG-U133A

FZD4 PAFAH1B3 APP

5.66e-041981931740_UP
DrugMolsidomine [25717-80-0]; Up 200; 16.6uM; HL60; HG-U133A

GSR PAFAH1B3 APP

5.66e-041981931711_UP
DrugChloroquine diphosphate [50-63-5]; Up 200; 7.8uM; HL60; HG-U133A

TRIP11 GSR PAFAH1B3

5.66e-041981931719_UP
DrugBetulinic acid [472-15-1]; Down 200; 8.8uM; MCF7; HT_HG-U133A

TRIP11 SMPDL3B APP

5.66e-041981933281_DN
DrugNitrofural [59-87-0]; Down 200; 20.2uM; MCF7; HT_HG-U133A

FZD4 SMPDL3B APP

5.75e-041991935321_DN
DrugZimelidine dihydrochloride monohydrate [61129-30-4]; Up 200; 9.8uM; HL60; HG-U133A

TRIP11 NIPBL PAFAH1B3

5.75e-041991932012_UP
DrugAcyclovir [59277-89-3]; Up 200; 17.8uM; HL60; HG-U133A

TRIP11 ZNF426 APP

5.83e-042001932044_UP
DrugNaphazoline hydrochloride [550-99-2]; Down 200; 16.2uM; HL60; HG-U133A

NIPBL GSR APP

5.83e-042001931966_DN
DrugPhenindione [83-12-5]; Up 200; 18uM; MCF7; HT_HG-U133A

APBA1 TRIP11 APP

5.83e-042001935991_UP
DrugLetrozole [112809-51-5]; Down 200; 14uM; MCF7; HT_HG-U133A

FZD4 NIPBL APP

5.83e-042001937336_DN
DrugDipyrone [5907-38-0]; Down 200; 12uM; HL60; HT_HG-U133A

TRIP11 ZNF426 APP

5.83e-042001932175_DN
DrugAcetylsalicylsalicylic acid [530-75-6]; Down 200; 13.4uM; PC3; HT_HG-U133A

TRIP11 NIPBL APP

5.83e-042001932061_DN
DrugAmitrole

GSR APP

5.84e-0443192ctd:D000640
DrugNSC53670

GSR APP

6.11e-0444192CID000243583
Drugcoenzyme Q10

GSR APP

7.27e-0448192ctd:C024989
Drugladostigil

GSR APP

7.58e-0449192CID000208907
DrugAC1L9M5J

FZD4 GSR APP

7.79e-04221193CID000448615
Drugthymoquinone

GSR APP

7.89e-0450192ctd:C003466
DiseaseDegenerative Diseases, Central Nervous System

GSR APP

2.57e-0439182C0270715
DiseaseDegenerative Diseases, Spinal Cord

GSR APP

2.57e-0439182C0751733
DiseaseNeurodegenerative Disorders

GSR APP

2.57e-0439182C0524851
Diseasecorpus callosum posterior volume measurement

RBM6 PDZRN4

4.58e-0452182EFO_0010298
DiseaseAlzheimer's disease (biomarker_via_orthology)

GSR APP

5.69e-0458182DOID:10652 (biomarker_via_orthology)
Diseasewaist-hip ratio

RBM6 TRIP11 KIAA2013 EPC1 PDZRN4

6.69e-041226185EFO_0004343

Protein segments in the cluster

PeptideGeneStartEntry
HSDYDSVFHHLDLEM

EPC1

471

Q9H2F5
HHSGYLADDEASHSM

CCDC116

6

Q8IYX3
MDAEFRHDSGYEVHH

APP

671

P05067
TAVHSEFMHDHADYG

GSR

116

P00390
DSCHSLHPMEHEFYE

PDZRN4

366

Q6ZMN7
SDGTISHHDMYDYLH

PAFAH1B3

181

Q15102
GHHHTDSFRMLYDDA

SMPDL3B

276

Q92485
AIGYCTDHESSSHHD

NFE2L3

446

Q9Y4A8
HGSSEDYLHMVHRLS

NIPBL

241

Q6KC79
GHEAIEMHSSYFHIA

FZD4

336

Q9ULV1
HFHSLEHEEAMNAAY

APBA1

151

Q02410
QLFMDDDSYSHHSGL

CAV2

11

P51636
KRRNDSGDHSDHMHY

RBM6

741

P78332
HSHSSFSAMAHDALF

PIGA

126

P37287
GAHYSHGDSMKHFST

ZNF587B

211

E7ETH6
SHHPSAFHDDDMDFG

TRIP11

151

Q15643
MAAADLSHGHYLSGD

ZNF426

1

Q9BUY5
HHHSAAAAAAAAAEM

ZIC2

21

O95409
YEDHCFSGHATMHAE

KIAA2013

396

Q8IYS2