Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ornithine decarboxylase activator activity	AZIN2 AZIN1	1.32e-05	2	73	2	GO:0042978
GeneOntologyMolecularFunction	floppase activity	RFT1 ATP8B2 ABCB1	2.54e-05	16	73	3	GO:0140328
GeneOntologyMolecularFunction	transporter activity	SLC22A9 GJA5 SLC27A6 SCN7A SV2C SLC7A5 RFT1 SLC39A10 SLC4A5 ATP8B2 MFSD12 NDUFS3 RYR2 RYR3 ABCB1	5.42e-05	1289	73	15	GO:0005215
GeneOntologyMolecularFunction	ornithine decarboxylase activity	AZIN2 AZIN1	7.87e-05	4	73	2	GO:0004586
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR2 RYR3	7.87e-05	4	73	2	GO:0005219
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC22A9 SLC27A6 SLC7A5 SLC39A10 SLC4A5 MFSD12 ABCB1	9.71e-05	293	73	7	GO:0008514
GeneOntologyMolecularFunction	ornithine decarboxylase regulator activity	AZIN2 AZIN1	1.31e-04	5	73	2	GO:0042979
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	RFT1 ATP8B2 ABCB1	1.44e-04	28	73	3	GO:0140326
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR2 RYR3	1.96e-04	6	73	2	GO:0048763
GeneOntologyMolecularFunction	carboxy-lyase activity	AZIN2 PCK1 AZIN1	3.07e-04	36	73	3	GO:0016831
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC22A9 GJA5 SLC27A6 SCN7A SV2C SLC7A5 SLC39A10 SLC4A5 MFSD12 NDUFS3 RYR2 RYR3 ABCB1	3.14e-04	1180	73	13	GO:0022857
GeneOntologyMolecularFunction	phosphatidylcholine floppase activity	ATP8B2 ABCB1	3.64e-04	8	73	2	GO:0090554
GeneOntologyMolecularFunction	lipid transporter activity	SLC22A9 SLC27A6 RFT1 ATP8B2 ABCB1	7.57e-04	196	73	5	GO:0005319
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	RFT1 ATP8B2 ABCB1	8.61e-04	51	73	3	GO:0140303
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC22A9 SLC27A6 SLC7A5 MFSD12 ABCB1	9.67e-04	207	73	5	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC22A9 SLC27A6 SLC7A5 MFSD12 ABCB1	9.89e-04	208	73	5	GO:0005342
GeneOntologyMolecularFunction	monoatomic cation:bicarbonate symporter activity	SLC39A10 SLC4A5	1.00e-03	13	73	2	GO:0140410
GeneOntologyMolecularFunction	lyase activity	AZIN2 POLG ALAD PCK1 AZIN1	1.08e-03	212	73	5	GO:0016829
GeneOntologyMolecularFunction	carbon-carbon lyase activity	AZIN2 PCK1 AZIN1	1.13e-03	56	73	3	GO:0016830
GeneOntologyMolecularFunction	glycerophospholipid flippase activity	ATP8B2 ABCB1	1.17e-03	14	73	2	GO:0140333
GeneOntologyMolecularFunction	glucosidase activity	MGAM LCT	1.34e-03	15	73	2	GO:0015926
GeneOntologyMolecularFunction	flippase activity	ATP8B2 ABCB1	1.73e-03	17	73	2	GO:0140327
GeneOntologyMolecularFunction	ATP-dependent activity	DNAH3 SLC27A6 MYO7A RFT1 DNAH7 ATP8B2 ZRANB3 ABCB1	1.77e-03	614	73	8	GO:0140657
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC22A9 SLC7A5 SLC39A10 SLC4A5 MFSD12 NDUFS3 ABCB1	1.78e-03	477	73	7	GO:0022804
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR2 RYR3	1.94e-03	18	73	2	GO:0015278
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH3 DNAH7	1.94e-03	18	73	2	GO:0008569
GeneOntologyMolecularFunction	phosphatidylcholine transporter activity	ATP8B2 ABCB1	2.40e-03	20	73	2	GO:0008525
GeneOntologyMolecularFunction	fatty acid transmembrane transporter activity	SLC22A9 SLC27A6	3.17e-03	23	73	2	GO:0015245
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC22A9 SLC7A5 SLC39A10 SLC4A5 MFSD12	4.57e-03	296	73	5	GO:0015291
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH3 DNAH7	4.69e-03	28	73	2	GO:0051959
GeneOntologyMolecularFunction	lysine-acetylated histone binding	MLLT1 MLLT3	5.37e-03	30	73	2	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	MLLT1 MLLT3	5.72e-03	31	73	2	GO:0140033
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR2 RYR3	5.72e-03	31	73	2	GO:0099604
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC39A10 SLC4A5	6.09e-03	32	73	2	GO:0015106
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	MGAM MAN1A2 LCT	6.38e-03	103	73	3	GO:0004553
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR2 RYR3	6.47e-03	33	73	2	GO:0005217
GeneOntologyMolecularFunction	spectrin binding	MYO7A CAMSAP3	6.86e-03	34	73	2	GO:0030507
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH3 DNAH7	8.08e-03	37	73	2	GO:0045505
GeneOntologyBiologicalProcess	positive regulation of polyamine transmembrane transport	AZIN2 AZIN1	1.20e-05	2	72	2	GO:1902269
GeneOntologyBiologicalProcess	response to nutrient	ACACB LIPG BCHE ALAD LCT BECN1	5.64e-05	192	72	6	GO:0007584
GeneOntologyBiologicalProcess	putrescine biosynthetic process from ornithine	AZIN2 AZIN1	7.18e-05	4	72	2	GO:0033387
GeneOntologyBiologicalProcess	disaccharide catabolic process	MGAM LCT	7.18e-05	4	72	2	GO:0046352
GeneOntologyBiologicalProcess	regulation of atrial cardiac muscle cell action potential	GJA5 RYR2	7.18e-05	4	72	2	GO:0098910
GeneOntologyBiologicalProcess	organic anion transport	SLC22A9 RAB3GAP1 ACACB SLC27A6 SLC7A5 SLC39A10 SLC4A5 MFSD12 ABCB1	7.40e-05	515	72	9	GO:0015711
GeneOntologyBiologicalProcess	response to lead ion	ALAD LCT BECN1	8.88e-05	25	72	3	GO:0010288
GeneOntologyBiologicalProcess	regulation of AV node cell action potential	GJA5 RYR2	1.19e-04	5	72	2	GO:0098904
GeneOntologyBiologicalProcess	regulation of polyamine transmembrane transport	AZIN2 AZIN1	1.19e-04	5	72	2	GO:1902267
GeneOntologyBiologicalProcess	response to nutrient levels	ACACB LIPG SLC7A5 BCHE ALAD LCT BECN1 MEAK7 PCK1	1.51e-04	566	72	9	GO:0031667
GeneOntologyBiologicalProcess	response to iron ion	ALAD LCT BECN1	1.71e-04	31	72	3	GO:0010039
GeneOntologyBiologicalProcess	putrescine biosynthetic process	AZIN2 AZIN1	1.79e-04	6	72	2	GO:0009446
GeneOntologyBiologicalProcess	Purkinje myocyte to ventricular cardiac muscle cell communication	GJA5 RYR2	1.79e-04	6	72	2	GO:0086068
GeneOntologyBiologicalProcess	Purkinje myocyte to ventricular cardiac muscle cell signaling	GJA5 RYR2	1.79e-04	6	72	2	GO:0086029
GeneOntologyBiologicalProcess	response to aluminum ion	ALAD BECN1	1.79e-04	6	72	2	GO:0010044
GeneOntologyBiologicalProcess	carboxylic acid transmembrane transport	SLC22A9 ACACB SLC7A5 MFSD12 ABCB1	2.65e-04	163	72	5	GO:1905039
GeneOntologyBiologicalProcess	response to activity	SLC7A5 ALAD PCK1 RYR2	2.78e-04	90	72	4	GO:0014823
GeneOntologyBiologicalProcess	organic acid transmembrane transport	SLC22A9 ACACB SLC7A5 MFSD12 ABCB1	2.96e-04	167	72	5	GO:1903825
GeneOntologyBiologicalProcess	response to iron(II) ion	LCT BECN1	3.32e-04	8	72	2	GO:0010040
GeneOntologyBiologicalProcess	positive regulation of transmembrane transport	RELN AZIN2 SLC7A5 RYR2 ABCB1 AZIN1	3.83e-04	273	72	6	GO:0034764
GeneOntologyBiologicalProcess	putrescine metabolic process	AZIN2 AZIN1	4.26e-04	9	72	2	GO:0009445
GeneOntologyCellularComponent	external side of apical plasma membrane	SLC7A5 LCT ABCB1	8.11e-07	6	73	3	GO:0098591
GeneOntologyCellularComponent	endoplasmic reticulum membrane	RAB3GAP1 RAB9A POMGNT2 SLC27A6 ALG11 ERGIC2 RFT1 MBOAT4 BECN1 TMEM86A ATP8B2 RYR2 RYR3	4.87e-04	1293	73	13	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	RAB3GAP1 RAB9A POMGNT2 SLC27A6 ALG11 ERGIC2 RFT1 MBOAT4 BECN1 TMEM86A ATP8B2 RYR2 RYR3	5.08e-04	1299	73	13	GO:0098827
GeneOntologyCellularComponent	inner dynein arm	DNAH3 DNAH7	5.32e-04	10	73	2	GO:0036156
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	RAB3GAP1 RAB9A POMGNT2 SLC27A6 ALG11 ERGIC2 RFT1 MBOAT4 BECN1 TMEM86A ATP8B2 RYR2 RYR3	6.22e-04	1327	73	13	GO:0042175
Domain	Orn_de-COase	AZIN2 AZIN1	4.39e-05	3	72	2	IPR002433
Domain	-	AZIN2 AZIN1	4.39e-05	3	72	2	2.40.37.10
Domain	Ala_racemase/Decarboxylase_C	AZIN2 AZIN1	4.39e-05	3	72	2	IPR009006
Domain	Ryanrecept_TM4-6	RYR2 RYR3	4.39e-05	3	72	2	IPR009460
Domain	Orn_Arg_deC_N	AZIN2 AZIN1	4.39e-05	3	72	2	PF02784
Domain	De-COase2_CS	AZIN2 AZIN1	4.39e-05	3	72	2	IPR022657
Domain	De-COase2_N	AZIN2 AZIN1	4.39e-05	3	72	2	IPR022644
Domain	De-COase2_C	AZIN2 AZIN1	4.39e-05	3	72	2	IPR022643
Domain	ODR_DC_2_1	AZIN2 AZIN1	4.39e-05	3	72	2	PS00878
Domain	ODR_DC_2_2	AZIN2 AZIN1	4.39e-05	3	72	2	PS00879
Domain	RyR	RYR2 RYR3	4.39e-05	3	72	2	PF02026
Domain	Ryanodine_rcpt	RYR2 RYR3	4.39e-05	3	72	2	IPR003032
Domain	Orn_DAP_Arg_deC	AZIN2 AZIN1	4.39e-05	3	72	2	PF00278
Domain	RR_TM4-6	RYR2 RYR3	4.39e-05	3	72	2	PF06459
Domain	Orn/DAP/Arg_de-COase	AZIN2 AZIN1	4.39e-05	3	72	2	IPR000183
Domain	Ryan_recept	RYR2 RYR3	4.39e-05	3	72	2	IPR013333
Domain	-	AZIN2 AZIN1	8.75e-05	4	72	2	3.20.20.10
Domain	PLP-binding_barrel	AZIN2 AZIN1	8.75e-05	4	72	2	IPR029066
Domain	YEATS	MLLT1 MLLT3	8.75e-05	4	72	2	IPR005033
Domain	YEATS	MLLT1 MLLT3	8.75e-05	4	72	2	PS51037
Domain	YEATS	MLLT1 MLLT3	8.75e-05	4	72	2	PF03366
Domain	RIH_assoc	RYR2 RYR3	2.18e-04	6	72	2	PF08454
Domain	RIH_assoc-dom	RYR2 RYR3	2.18e-04	6	72	2	IPR013662
Domain	RIH_dom	RYR2 RYR3	2.18e-04	6	72	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 RYR3	2.18e-04	6	72	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 RYR3	2.18e-04	6	72	2	IPR015925
Domain	-	RYR2 RYR3	2.18e-04	6	72	2	1.25.10.30
Domain	RYDR_ITPR	RYR2 RYR3	2.18e-04	6	72	2	PF01365
Domain	Ins145_P3_rec	RYR2 RYR3	2.18e-04	6	72	2	PF08709
Domain	MIR	RYR2 RYR3	6.46e-04	10	72	2	PS50919
Domain	MIR	RYR2 RYR3	6.46e-04	10	72	2	PF02815
Domain	MIR	RYR2 RYR3	6.46e-04	10	72	2	SM00472
Domain	MIR_motif	RYR2 RYR3	6.46e-04	10	72	2	IPR016093
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH7	1.29e-03	14	72	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH7	1.29e-03	14	72	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH7	1.29e-03	14	72	2	IPR013602
Domain	DHC_N2	DNAH3 DNAH7	1.29e-03	14	72	2	PF08393
Domain	MT	DNAH3 DNAH7	1.29e-03	14	72	2	PF12777
Domain	AAA_8	DNAH3 DNAH7	1.29e-03	14	72	2	PF12780
Domain	DHC_fam	DNAH3 DNAH7	1.49e-03	15	72	2	IPR026983
Domain	Dynein_heavy_dom	DNAH3 DNAH7	1.49e-03	15	72	2	IPR004273
Domain	Dynein_heavy	DNAH3 DNAH7	1.49e-03	15	72	2	PF03028
Domain	Cupredoxin	PKHD1L1 HEPH	3.22e-03	22	72	2	IPR008972
Domain	MFS_1	SLC22A9 SV2C MFSD12	3.28e-03	77	72	3	PF07690
Domain	MFS	SLC22A9 SV2C MFSD12	3.28e-03	77	72	3	IPR011701
Pubmed	Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse.	RELN MLLT1 MLLT3	1.05e-06	10	73	3	19000783
Pubmed	Recurrent emergence of catalytically inactive ornithine decarboxylase homologous forms that likely have regulatory function.	AZIN2 AZIN1	4.35e-06	2	73	2	20217058
Pubmed	Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.	RYR2 RYR3	4.35e-06	2	73	2	21531043
Pubmed	The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) - Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer.	MLLT1 MLLT3	4.35e-06	2	73	2	34174329
Pubmed	Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.	RYR2 RYR3	4.35e-06	2	73	2	16678258
Pubmed	Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.	RYR2 RYR3	4.35e-06	2	73	2	8898078
Pubmed	The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.	RYR2 RYR3	4.35e-06	2	73	2	14550562
Pubmed	Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in mammalian cells.	AZIN2 AZIN1	4.35e-06	2	73	2	18508777
Pubmed	Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.	RYR2 RYR3	4.35e-06	2	73	2	14985349
Pubmed	Constitutive Intracellular Na+ Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress Than Ventricular Myocytes From Mice With Catecholaminergic Polymorphic Ventricular Tachycardia.	GJA5 RYR2	4.35e-06	2	73	2	27169737
Pubmed	An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias.	MLLT1 MLLT3	4.35e-06	2	73	2	25509985
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	RAB3GAP1 ACACB MYO7A AZIN2 LPO USP24 ALG11 DNAH7 RYR2	7.59e-06	638	73	9	31182584
Pubmed	Localization of the reeler gene relative to flanking loci on mouse chromosome 5.	RELN ABCB1	1.30e-05	3	73	2	1686837
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR2 RYR3	1.30e-05	3	73	2	18403125
Pubmed	Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.	RAB9A BECN1	1.30e-05	3	73	2	35018428
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR2 RYR3	1.30e-05	3	73	2	18434746
Pubmed	Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.	RYR2 RYR3	1.30e-05	3	73	2	29730765
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR2 RYR3	1.30e-05	3	73	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR2 RYR3	1.30e-05	3	73	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR2 RYR3	1.30e-05	3	73	2	21881589
Pubmed	The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3.	MLLT1 MLLT3	1.30e-05	3	73	2	11313972
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR2 RYR3	1.30e-05	3	73	2	12213830
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR2 RYR3	1.30e-05	3	73	2	9242641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR2 RYR3	1.30e-05	3	73	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR2 RYR3	1.30e-05	3	73	2	10788707
Pubmed	RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.	RYR2 RYR3	1.30e-05	3	73	2	15024040
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR2 RYR3	1.30e-05	3	73	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR2 RYR3	1.30e-05	3	73	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR2 RYR3	1.30e-05	3	73	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR2 RYR3	1.30e-05	3	73	2	11159936
Pubmed	Mouse multidrug resistance 1a/3 gene is the earliest known endothelial cell differentiation marker during blood-brain barrier development.	RELN ABCB1	1.30e-05	3	73	2	7734734
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR2 RYR3	1.30e-05	3	73	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR2 RYR3	1.30e-05	3	73	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR2 RYR3	1.30e-05	3	73	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR2 RYR3	1.30e-05	3	73	2	7635066
Pubmed	Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4.	MLLT1 MLLT3	2.60e-05	4	73	2	25282333
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR2 RYR3	2.60e-05	4	73	2	18206662
Pubmed	Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.	ACACB PCK1	2.60e-05	4	73	2	38447582
Pubmed	Direct detection and isolation of restriction landmark genomic scanning (RLGS) spot DNA markers tightly linked to a specific trait by using the RLGS spot-bombing method.	RELN ABCB1	2.60e-05	4	73	2	7777557
Pubmed	Estimation of genetic distances between "reeler" and nearby loci on mouse chromosome 5.	RELN ABCB1	2.60e-05	4	73	2	1783386
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR2 RYR3	2.60e-05	4	73	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR2 RYR3	2.60e-05	4	73	2	9384575
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR2 RYR3	2.60e-05	4	73	2	9607712
Pubmed	A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes.	GJA5 RYR2	2.60e-05	4	73	2	33664309
Pubmed	The reeler gene: a clue to brain development and evolution.	RELN ABCB1	2.60e-05	4	73	2	1627461
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR2 RYR3	2.60e-05	4	73	2	23482488
Pubmed	Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis.	MLLT1 MLLT3	2.60e-05	4	73	2	16096649
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	PCYOX1L MAN1A2 POMGNT2 ALG11 SLC7A5 ERGIC2 PRSS23 RFT1 SLC39A10 PTK7 NRP1	3.98e-05	1201	73	11	35696571
Pubmed	Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.	RYR2 RYR3	4.33e-05	5	73	2	33060591
Pubmed	Structure, genetic mapping, and expression of the mouse Hgf/scatter factor gene.	RELN ABCB1	4.33e-05	5	73	2	8081873
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR2 RYR3	4.33e-05	5	73	2	23918386
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR2 RYR3	4.33e-05	5	73	2	19011160
Pubmed	Requirement for early-generated neurons recognized by monoclonal antibody lot1 in the formation of lateral olfactory tract.	RELN NRP1	4.33e-05	5	73	2	9742149
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	GJA5 ACACB RYR2	5.07e-05	34	73	3	26378152
Pubmed	Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.	ALAD PRSS23 AZIN1	5.07e-05	34	73	3	12878157
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR2 RYR3	6.48e-05	6	73	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR2 RYR3	6.48e-05	6	73	2	26025922
Pubmed	Connexin Expression Is Altered in the Eye Development of Yotari Mice: A Preliminary Study.	GJA5 RELN	6.48e-05	6	73	2	39334940
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR2 RYR3	6.48e-05	6	73	2	23463619
Pubmed	High-resolution genetic map and YAC contig around the mouse neurological locus reeler.	RELN ABCB1	6.48e-05	6	73	2	7894155
Pubmed	Subcellular localization of antizyme inhibitor 2 in mammalian cells: Influence of intrinsic sequences and interaction with antizymes.	AZIN2 AZIN1	6.48e-05	6	73	2	19449338
Pubmed	Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos.	GJA5 NRP1	6.48e-05	6	73	2	18550715
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR2 RYR3	6.48e-05	6	73	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR2 RYR3	6.48e-05	6	73	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR2 RYR3	6.48e-05	6	73	2	25966694
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR2 RYR3	6.48e-05	6	73	2	19009018
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR2 RYR3	6.48e-05	6	73	2	16844763
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR2 RYR3	9.06e-05	7	73	2	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR2 RYR3	9.06e-05	7	73	2	20962236
Pubmed	Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.	ACACB LIPG PCK1 ABCB1	1.11e-04	117	73	4	18996102
Pubmed	Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin.	MLLT1 MLLT3	1.21e-04	8	73	2	21873227
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR2 RYR3	1.21e-04	8	73	2	19033399
Pubmed	Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom).	MLLT1 MLLT3	1.21e-04	8	73	2	20203130
Pubmed	A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.	SEMA3G NRP1	1.21e-04	8	73	2	27180624
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR2 RYR3	1.21e-04	8	73	2	11784029
Pubmed	Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.	FANCC LIPG AZIN1	1.93e-04	53	73	3	14499622
Pubmed	A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.	MLLT1 MLLT3	1.93e-04	10	73	2	20153263
Pubmed	Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction.	GJA5 RYR2	1.93e-04	10	73	2	32672536
Pubmed	A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels.	GJA5 RYR2	1.93e-04	10	73	2	26897459
Pubmed	Human ALKBH4 interacts with proteins associated with transcription.	MLLT1 MLLT3	1.93e-04	10	73	2	23145062
Pubmed	Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea.	MYO7A SLC7A5	1.93e-04	10	73	2	21878515
Pubmed	Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.	GJA5 ACACB BECN1	2.15e-04	55	73	3	27997827
Pubmed	Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation.	SLC7A5 ABCB1	2.36e-04	11	73	2	18619525
Pubmed	The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly.	GJA5 RYR2	2.36e-04	11	73	2	27217161
Pubmed	HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.	MLLT1 MLLT3	2.36e-04	11	73	2	20471949
Pubmed	Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.	SEMA3G NRP1	2.83e-04	12	73	2	19812329
Pubmed	AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan.	POMGNT2 LARGE1	2.83e-04	12	73	2	24256719
Pubmed	Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.	SEMA3G NRP1	2.83e-04	12	73	2	23991118
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR2 RYR3	2.83e-04	12	73	2	19095005
Pubmed	The little elongation complex regulates small nuclear RNA transcription.	MLLT1 MLLT3	2.83e-04	12	73	2	22195968
Pubmed	Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b.	MYO7A PTK7	2.83e-04	12	73	2	20215345
Pubmed	Maternal Calorie Restriction Induces a Transcriptional Cytoprotective Response in Embryonic Liver Partially Dependent on Nrf2.	ACACB PCK1	3.34e-04	13	73	2	36421460
Pubmed	Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy.	LIPG ABCB1	3.34e-04	13	73	2	17700364
Pubmed	Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin.	GJA5 NRP1	3.34e-04	13	73	2	23395391
Pubmed	Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1.	GJA5 SEMA3G	3.34e-04	13	73	2	27880905
Pubmed	Transcriptional and posttranscriptional regulation of HIV-1 gene expression.	MLLT1 MLLT3	3.34e-04	13	73	2	22355797
Pubmed	Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb.	RELN NRP1	3.34e-04	13	73	2	18024993
Pubmed	Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.	GJA5 NRP1	3.34e-04	13	73	2	22723296
Pubmed	Tag1 deficiency results in olfactory dysfunction through impaired migration of mitral cells.	RELN NRP1	3.34e-04	13	73	2	26525675
Pubmed	MED12 regulates a transcriptional network of calcium-handling genes in the heart.	GJA5 RYR2	3.89e-04	14	73	2	28724790
Cytoband	2q32.3	SLC39A10 DNAH7	1.63e-04	12	73	2	2q32.3
Cytoband	2q21.3	RAB3GAP1 ZRANB3	2.58e-04	15	73	2	2q21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr2q21	RAB3GAP1 LCT ZRANB3	1.83e-03	151	73	3	chr2q21
Cytoband	Ensembl 112 genes in cytogenetic band chr11p11	OR4X2 NDUFS3 OR4C5	1.90e-03	153	73	3	chr11p11
Cytoband	3p21.1	SEMA3G RFT1	2.06e-03	42	73	2	3p21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8q23	ABRA PKHD1L1	3.02e-03	51	73	2	chr8q23
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR2 RYR3	1.81e-05	3	45	2	287
GeneFamily	Super elongation complex\|YEATS domain containing	MLLT1 MLLT3	3.62e-05	4	45	2	1283
GeneFamily	AF4/FMR2 family\|Super elongation complex	MLLT1 MLLT3	2.16e-04	9	45	2	1280
GeneFamily	Dyneins, axonemal	DNAH3 DNAH7	8.04e-04	17	45	2	536
GeneFamily	Solute carriers	SLC22A9 SLC27A6 SLC7A5 SLC39A10 SLC4A5	2.89e-03	395	45	5	752
Coexpression	GSE27786_LIN_NEG_VS_MONO_MAC_DN	GJA5 MYO7A MAP3K8 TMEM86A RYR3 SNX13	1.88e-05	200	72	6	M4798
Coexpression	GSE18893_TCONV_VS_TREG_2H_TNF_STIM_UP	MGAM GJA5 AZIN2 ALG11 PCK1 AZIN1	1.88e-05	200	72	6	M7297
Coexpression	GSE17721_0.5H_VS_8H_PAM3CSK4_BMDC_DN	FANCC MAN1A2 NYNRIN BCHE ERGIC2 AZIN1	1.88e-05	200	72	6	M4111
Coexpression	ZHENG_FOXP3_TARGETS_UP	MAP3K8 ABCB1 NRP1	4.94e-05	26	72	3	MM1220
Coexpression	ZHENG_FOXP3_TARGETS_UP	MAP3K8 ABCB1 NRP1	4.94e-05	26	72	3	M1753
ToppCell	Adult-Endothelial\|Adult / Lineage, Cell type, age group and donor	PALD1 GJA5 RELN SEMA3G PRSS23 PKHD1L1	7.96e-07	194	73	6	963b3fbee0575af8379baa397ace65949eaf34f7
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GJA5 SLC7A5 SEMA3G PRSS23 SLC39A10 ABCB1	8.45e-07	196	73	6	889c9fed857f64664ca1f47fcec9fecb15ed103c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GJA5 SLC7A5 SEMA3G PRSS23 SLC39A10 ABCB1	8.71e-07	197	73	6	e567f91fa398fd306d025dcfe89bd50a60216537
ToppCell	ASK428-Endothelial\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	PALD1 GJA5 RELN SEMA3G PRSS23 PKHD1L1	8.97e-07	198	73	6	d69d0ff115298596173a4278897a65007a71f5df
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	8.37e-06	168	73	5	7abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	8.86e-06	170	73	5	021c3e45955d18e241f7d98acdf22076fee4fc43
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	8.86e-06	170	73	5	417b77c12a7982b1ce4b4bc57f30335d261220f5
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJA5 MYO7A FFAR2 LPO TMEM86A	9.12e-06	171	73	5	dca4aa921896ec935fb7acdf25a62d8eba679602
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJA5 MYO7A FFAR2 LPO TMEM86A	9.12e-06	171	73	5	add2f7d34889ec654b8c71b4b1f084736111dc88
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	9.64e-06	173	73	5	95c723b09254ae7131fe5ba0841472502e83269b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	9.92e-06	174	73	5	e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.02e-05	175	73	5	90e29945aa861082c94bb4f331161adc3a6ef899
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DNAH3 RELN SCN7A PKHD1L1 ATP8B2	1.02e-05	175	73	5	9a96a946db731ba24c9be34bedebf1f4a1372b9e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DNAH3 RELN SCN7A PKHD1L1 ATP8B2	1.02e-05	175	73	5	54c1f080195ad8392a095e83b56a4b54073d4c0d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DNAH3 RELN SCN7A PKHD1L1 ATP8B2	1.02e-05	175	73	5	2b51406a2c2daa13ab4ed283ede038cd11d9e641
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.05e-05	176	73	5	e4b21fd6a5e0c5950f27c3e1868318e48330ae5e
ToppCell	356C-Fibroblasts-Fibroblast-G\|356C / Donor, Lineage, Cell class and subclass (all cells)	SCN7A BCHE HEPH RYR2 NRP1	1.08e-05	177	73	5	8220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.08e-05	177	73	5	4c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell	356C-Fibroblasts-Fibroblast-G-\|356C / Donor, Lineage, Cell class and subclass (all cells)	SCN7A BCHE HEPH RYR2 NRP1	1.08e-05	177	73	5	7617270f49cd6b7ba66db72d20560cee985012b2
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.08e-05	177	73	5	bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.14e-05	179	73	5	7954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.14e-05	179	73	5	f65889bf1e41396979cce44a5e63f49dea2bbd9b
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ALG11 PRSS23 TMEM86A ZRANB3 LARGE1	1.14e-05	179	73	5	ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.17e-05	180	73	5	b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.20e-05	181	73	5	08f44323bf71b6004a921bbc969c954c75feeb66
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.27e-05	183	73	5	65f2a5895d166189a095cf7ea9dda171f0419b08
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM RELN PKHD1L1 RYR2 RYR3	1.30e-05	184	73	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM RELN PKHD1L1 RYR2 RYR3	1.30e-05	184	73	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM RELN PKHD1L1 RYR2 RYR3	1.30e-05	184	73	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN PRSS23 PKHD1L1 ZRANB3 RYR3	1.33e-05	185	73	5	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	Healthy_donor-pDC\|Healthy_donor / disease group, cell group and cell class (v2)	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.33e-05	185	73	5	7fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCell	Adult-Endothelial-endothelial_cell_of_artery\|Adult / Lineage, Cell type, age group and donor	GJA5 CPAMD8 SEMA3G PRSS23 RYR3	1.37e-05	186	73	5	2d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCell	COVID-19_Mild-pDC\|COVID-19_Mild / Disease condition and Cell class	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.44e-05	188	73	5	62d33d2990d4a2d32bd0863147e47f656df1966e
ToppCell	ASK428-Endothelial-Lymphatic\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	PALD1 RELN BCHE PKHD1L1 HEPH	1.44e-05	188	73	5	c371bc340966cfe9205cbf4b62c6452f49f2559f
ToppCell	COVID-19_Mild-pDC-\|COVID-19_Mild / Disease condition and Cell class	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.44e-05	188	73	5	a75c2cf2f8dae343c13aaa66b637658b935ed10a
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PALD1 RELN SLC7A5 PRSS23 PKHD1L1	1.44e-05	188	73	5	aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell	COVID-19_Mild-Myeloid-pDC\|COVID-19_Mild / Disease group, lineage and cell class	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.48e-05	189	73	5	c6cfd6aa21c19f2c62d80218bbc924e14e82aada
ToppCell	Control-Myeloid-pDC\|Control / Disease group, lineage and cell class	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.48e-05	189	73	5	46770b99da42f11f10cfc67cea8562342d60b867
ToppCell	PBMC-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.52e-05	190	73	5	adffa93635da10251f28b2089fd96b189775c8b4
ToppCell	PBMC-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.52e-05	190	73	5	9a91bf1ea105029e6412d0d9060bca325299ce26
ToppCell	PBMC-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.52e-05	190	73	5	39c8ddc2639bf3e986dae11fbae61a735614b604
ToppCell	PBMC-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.52e-05	190	73	5	2c1c079fd411c03bc3f383aa927eea9446716960
ToppCell	PBMC-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.52e-05	190	73	5	a95aea3aa707fc4574810706341a5f32b3d00209
ToppCell	PBMC-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.52e-05	190	73	5	18dfa84c62dcf081ce9958a71e76a394ec0968e4
ToppCell	Control-pDC\|Control / Disease condition and Cell class	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.56e-05	191	73	5	543e1437a52d04436862dd1c27b4fae95c44fcc8
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	GJA5 SCN7A BCHE RYR2 NRP1	1.56e-05	191	73	5	fa380a8752de158974b2ae5e741573439719cc0d
ToppCell	Control-pDC-\|Control / Disease condition and Cell class	PALD1 AZIN2 SLC7A5 PTK7 NRP1	1.56e-05	191	73	5	1d7b0fae4d114d6db933c18b4eb2066ffa61356d
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GJA5 SEMA3G PRSS23 NRP1 AZIN1	1.56e-05	191	73	5	27f23c2254b610abac1a88d0fecff305addde9da
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GJA5 SEMA3G PKHD1L1 RYR3	1.76e-05	196	73	5	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GJA5 SEMA3G PKHD1L1 RYR3	1.76e-05	196	73	5	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	HECTD4 SV2C ALAD PKHD1L1 PCK1	1.89e-05	199	73	5	565404c155dfac57c020a8f2d09cbf756da20ffd
ToppCell	Bronchial-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PALD1 GJA5 RELN PRSS23 PKHD1L1	1.89e-05	199	73	5	36a230b80096455df26c2e2c8c05fd6b231508c5
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	HECTD4 SV2C ALAD PKHD1L1 PCK1	1.89e-05	199	73	5	6c174dbcc25b980f10a3d1dfe39e613acac73bb6
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GJA5 CPAMD8 ACACB SEMA3G ABCB1	1.89e-05	199	73	5	bd43a84e84d8acb8e1008b98a235cc5bd5f43586
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC7A5 SEMA3G PRSS23 SLC39A10 ABCB1	1.89e-05	199	73	5	236b1417ed0875e98c6ec1ec714003bfce438d65
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	HECTD4 SV2C ALAD PKHD1L1 PCK1	1.89e-05	199	73	5	284ee9632413f6404fc0b0c7c393ad813db834f2
ToppCell	5'-Adult-LargeIntestine-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GJA5 SEMA3G PRSS23 PKHD1L1 NRP1	1.89e-05	199	73	5	ffebd99d55d31cf51b4878b2690ed0b9b3799223
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	GJA5 MYO7A BCHE PRSS23 PTK7	1.94e-05	200	73	5	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	Neuronal-Excitatory-eD(FEZF2)-ABO-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.94e-05	200	73	5	e3051dcf9b5c8e4dc71a8080b7a7aafea46f2b2b
ToppCell	Neuronal-Excitatory-eD(FEZF2)-ABO--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.94e-05	200	73	5	1ce9599cc9d8158e8842ca56f35fa7809c234849
ToppCell	Parenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GJA5 CPAMD8 MLLT1 SEMA3G PRSS23	1.94e-05	200	73	5	e90ca26643f8496bdd6672c327da9855490d1aa8
ToppCell	Neuronal-Excitatory-eD(FEZF2)-ABO---L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.94e-05	200	73	5	7b845aabfbdfe893acc9334a5707833761bed60b
ToppCell	distal-1-Endothelial-Bronchial_Vessel_2\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GJA5 LIPG SEMA3G PRSS23 ABCB1	1.94e-05	200	73	5	aa8f8a0271c1363981e6ca1b2c1f0a8eb2652602
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	GJA5 MYO7A BCHE PRSS23 PTK7	1.94e-05	200	73	5	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	Neuronal-Excitatory-eD(FEZF2)-ABO\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MAP3K8 RYR3 PTK7 ABCB1 NRP1	1.94e-05	200	73	5	0638273fc0910f47fe7a0b6d9a8639b0e9976d13
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	GJA5 CPAMD8 BCHE PRSS23 PTK7	1.94e-05	200	73	5	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC22A9 GJA5 SEMA3G ATP8B2	2.22e-05	100	73	4	60c2bdee5d37dedf9be1e03b6b52b539a2277df3
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLC22A9 GJA5 SEMA3G ATP8B2	2.31e-05	101	73	4	de49feca7548640f85d206ebc56a58ab0bf7ac16
ToppCell	LA-10._Endothelium_II\|LA / Chamber and Cluster_Paper	CPAMD8 FFAR2 PKHD1L1 ABCB1	6.98e-05	134	73	4	048fa6ccf305d22d9a53db4ab385f39f558010d8
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LCT SLC4A5 PCK1 HEPH	9.99e-05	147	73	4	a5ed71afe5fcb4f541080f5552252695c7d4d090
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-9\|TCGA-Liver / Sample_Type by Project: Shred V9	POMGNT2 ACACB LIPG PPM1E	1.03e-04	148	73	4	683b2b80ee389469d948aaf6a77632b24f56e989
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LCT SLC4A5 PCK1 HEPH	1.05e-04	149	73	4	7726957b1de638c3bfc659381d15eab626bb179b
ToppCell	10x5'-Liver-Myeloid_Mac-Intestinal_macrophages\|Liver / Manually curated celltypes from each tissue	PALD1 NYNRIN NRP1 LARGE1	1.26e-04	156	73	4	9a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	DNAH3 RELN SV2C RYR2	1.35e-04	159	73	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	Bronchial_Biopsy-Endothelial-Lymphatic\|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X	RELN PPM1E BCHE PKHD1L1	1.49e-04	163	73	4	961c3a1303108afd680365466045f3460a30a7b0
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN MYO7A PRSS23 PKHD1L1	1.52e-04	164	73	4	4cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN MYO7A PRSS23 PKHD1L1	1.52e-04	164	73	4	7a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN MYO7A PRSS23 PKHD1L1	1.52e-04	164	73	4	5e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCell	PND10-Endothelial-Endothelial_lymphatic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN MYO7A PRSS23 PKHD1L1	1.52e-04	164	73	4	f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCell	NS-critical-d_07-13-Myeloid-pDC\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PALD1 SLC7A5 RFX4 NRP1	1.56e-04	165	73	4	17d5c4a111d9b5400780bc5e7b93ce2f5d69ceb7
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	RELN SCN7A BCHE RYR2	1.60e-04	166	73	4	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	RELN SCN7A BCHE RYR2	1.60e-04	166	73	4	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D122\|Adult / Lineage, Cell type, age group and donor	GJA5 CPAMD8 SEMA3G RYR3	1.67e-04	168	73	4	8c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCell	Endothelial-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	PALD1 RELN PRSS23 PKHD1L1	1.71e-04	169	73	4	95c617143e1fbdd1d55a93ffdcc210e0be37cf2f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GJA5 CPAMD8 SEMA3G PKHD1L1	1.71e-04	169	73	4	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	3'_v3-Lung-Myeloid_Mac-Intestinal_macrophages\|Lung / Manually curated celltypes from each tissue	PALD1 MYO7A NYNRIN NRP1	1.71e-04	169	73	4	241644823e6f949aaf4c671d4579721d7ef6b0e5
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	GJA5 TYW5 LIPG AADAT	1.79e-04	171	73	4	6a2f88c2a62cb2f69797804e24eb1137a3e148de
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	GJA5 TYW5 LIPG AADAT	1.79e-04	171	73	4	9be3554626408bb897d1f1c43b3ab4a92651f2e2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC7A5 SLC39A10 MFSD12 ABCB1	1.83e-04	172	73	4	c3a99828838af3b85c8c885d69cc8018f55ced50
ToppCell	Endothelial-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	RELN PRSS23 PKHD1L1 HEPH	1.83e-04	172	73	4	d4e98ff9c7cbc95457e1d71fa60f151a2f178dae
ToppCell	Bronchial_Biopsy-Endothelial-Lymphatic\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	PALD1 RELN BCHE PKHD1L1	1.83e-04	172	73	4	c41f5a66781bbf63afce7ca5d118cc6d8e0fe0bc
ToppCell	droplet-Spleen-SPLEEN-30m-Hematologic-erythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECTD4 MLLT3 SLC7A5 AZIN1	1.87e-04	173	73	4	a8fb8db6061fa4d8d56a7b45004ecbd344501573
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GJA5 CPAMD8 PKHD1L1	1.87e-04	173	73	4	f193c63cc536d891c9d23043765e320252bb6e65
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D122\|Adult / Lineage, Cell type, age group and donor	PALD1 RELN PRSS23 PKHD1L1	1.87e-04	173	73	4	dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCell	droplet-Heart-HEART-1m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN PRSS23 PKHD1L1 RYR3	1.87e-04	173	73	4	9dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GJA5 MBOAT4 NRP1	1.87e-04	173	73	4	afa6bb19df52541d8d17cbfac9cbdd18a5f3632d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC27A6 MAP3K8 PTK7 ABCB1	1.91e-04	174	73	4	912a9e892b29d945666fc37c986009c97c668ac8
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L5-6_FEZF2_ANKRD20A1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K8 RYR3 PTK7 NRP1	1.91e-04	174	73	4	99eb5e1aee136c7039e23b68a43a0fa3d775859f
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	GJA5 PRSS23 PKHD1L1 ABCB1	1.91e-04	174	73	4	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D175\|Adult / Lineage, Cell type, age group and donor	GJA5 CPAMD8 SEMA3G HEPH	1.95e-04	175	73	4	0a65ddfa8c2e8efb5b5338cf07661cb78157a23c
Drug	mag-fura-2	MGAM GJA5 RYR2 RYR3	5.61e-06	37	72	4	CID000123839
Drug	Biliton	DNAH3 MYO7A ASAH1 SLC4A5	8.52e-06	41	72	4	CID000002974
Drug	hydroxyl radicals	FANCC MGAM PCYOX1L MAN1A2 ASAH1 LIPG LPO PPM1E BCHE ALAD LCT ATP8B2 PCK1 PTK7 ABCB1	1.58e-05	1341	72	15	CID000000961
Drug	gabapentin	SCN7A SLC7A5 AADAT RYR2 RYR3 ABCB1	1.59e-05	169	72	6	CID000003446
Drug	AC1L380G	MGAM RYR2 RYR3	2.83e-05	19	72	3	CID000084698
Drug	Estrone	LPO SLC7A5 ALAD PRSS23 ABCB1	2.83e-05	112	72	5	ctd:D004970
Drug	L 30	LCT ABCB1	2.95e-05	3	72	2	CID000088832
Drug	cis-diammineplatinum(II	RYR2 RYR3	2.95e-05	3	72	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR2 RYR3	2.95e-05	3	72	2	CID002750949
Drug	Barbital	BCHE ALAD	2.95e-05	3	72	2	ctd:D001462
Drug	8N3-cADPR	RYR2 RYR3	2.95e-05	3	72	2	CID000127713
Drug	aminodantrolene	RYR2 RYR3	2.95e-05	3	72	2	CID009570289
Drug	dcaB	MGAM LPO	2.95e-05	3	72	2	CID000015340
Drug	2-hydroxycarbazole	RYR2 RYR3	2.95e-05	3	72	2	CID000093551
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR2 RYR3	2.95e-05	3	72	2	CID005748312
Drug	N(3)ATP	MGAM ABCB1	2.95e-05	3	72	2	CID000133414
Drug	methamidophos	BCHE ALAD BECN1	3.33e-05	20	72	3	ctd:C014655
Drug	Bephenium hydroxynaphthoate [3818-50-6]; Up 200; 9uM; PC3; HT_HG-U133A	LIPG RYR2 SNX13 PTK7 NRP1 LARGE1	3.78e-05	197	72	6	4668_UP
Drug	TPGS	MLLT1 MLLT3 ABCB1	3.87e-05	21	72	3	CID000071406
Drug	Chlorprothixene hydrochloride [6469-93-8]; Up 200; 11.4uM; HL60; HT_HG-U133A	DNAH3 MAP3K8 PPM1E USP24 ATP8B2 NRP1	3.89e-05	198	72	6	1272_UP
Drug	3,9-dimethyladenine	MGAM BCHE LCT	5.13e-05	23	72	3	CID000447936
Drug	PCB74	RYR2 RYR3	5.89e-05	4	72	2	CID000036218
Drug	nimbidiol	MGAM LCT	5.89e-05	4	72	2	ctd:C496111
Drug	148504-47-6	RYR2 RYR3	5.89e-05	4	72	2	CID006444275
Drug	SC 38249	RYR2 RYR3	5.89e-05	4	72	2	CID000134834
Drug	AC1L1U7A	RYR2 RYR3	5.89e-05	4	72	2	CID000035682
Drug	AC1L1IZE	MGAM DNAH3 MYO7A RYR2 RYR3	6.00e-05	131	72	5	CID000004799
Drug	NSC406942	MGAM POLG LPO BCHE AADAT LCT PCK1 RYR2 RYR3	7.10e-05	565	72	9	CID000001115
Drug	cisplatin	MLLT1 BCHE BECN1 HEPH ABCB1	7.95e-05	139	72	5	CID000002767
Drug	anthroylouabain	MGAM BCHE	9.80e-05	5	72	2	CID000124910
Drug	lactate	MGAM FARS2 POLG SCN7A LCT DNAH7 PCK1 NDUFS3	1.02e-04	461	72	8	CID000000612
Disease	epilepsy (is_implicated_in)	POLG BCHE ABCB1	1.16e-06	9	72	3	DOID:1826 (is_implicated_in)
Disease	status epilepticus (biomarker_via_orthology)	RELN POLG ALAD BECN1 ABCB1	4.72e-06	100	72	5	DOID:1824 (biomarker_via_orthology)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR2 RYR3	1.76e-05	3	72	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR2 RYR3	1.76e-05	3	72	2	DOID:8545 (implicated_via_orthology)
Disease	hepatocellular carcinoma (is_implicated_in)	POLG SLC7A5 RYR3 ABCB1 AZIN1	8.24e-05	181	72	5	DOID:684 (is_implicated_in)
Disease	Leigh Disease	FARS2 POLG NDUFS3	2.09e-04	47	72	3	C0023264
Disease	Parkinson Disease, Secondary Vascular	BCHE ABCB1	3.81e-04	12	72	2	C0751414
Disease	Atherosclerotic Parkinsonism	BCHE ABCB1	3.81e-04	12	72	2	C0751415
Disease	Secondary Parkinson Disease	BCHE ABCB1	3.81e-04	12	72	2	C0030569
Disease	Alzheimer disease, dementia	RFX4 CFAP46	3.81e-04	12	72	2	MONDO_0001627, MONDO_0004975
Disease	obsolete_red blood cell distribution width	RAB9A SLC27A6 FARS2 LIPG FFAR2 HECTD4 SV2C ALG11 SLC7A5 SNX13 ABCB1	4.02e-04	1347	72	11	EFO_0005192
Disease	mood disorder	RELN SV2C	4.50e-04	13	72	2	EFO_0004247
Disease	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2K	POMGNT2 LARGE1	5.24e-04	14	72	2	C1836373
Disease	alpha-Dystroglycanopathies	POMGNT2 LARGE1	5.24e-04	14	72	2	C2936406
Disease	Fukuyama Type Congenital Muscular Dystrophy	POMGNT2 LARGE1	5.24e-04	14	72	2	C0410174
Disease	Muscle eye brain disease	POMGNT2 LARGE1	5.24e-04	14	72	2	C0457133
Disease	Muscular Dystrophy-Dystroglycanopathy (Congenital with Brain and Eye Anomalies) Type A, 1	POMGNT2 LARGE1	5.24e-04	14	72	2	C4284790
Disease	Walker-Warburg congenital muscular dystrophy	POMGNT2 LARGE1	6.04e-04	15	72	2	C0265221
Disease	anemia (implicated_via_orthology)	ALAD SLC4A5	6.04e-04	15	72	2	DOID:2355 (implicated_via_orthology)
Disease	serum amyloid A-1 protein measurement	BCHE TMEM86A	8.76e-04	18	72	2	EFO_0008282
Disease	Tachycardia	BCHE RYR2	8.76e-04	18	72	2	C0039231
Disease	Tachyarrhythmia	BCHE RYR2	8.76e-04	18	72	2	C0080203
Disease	apolipoprotein A 1 measurement	MGAM ACACB LIPG RFX4 ZRANB3 SNX13 NRP1 AZIN1	1.06e-03	848	72	8	EFO_0004614
Disease	liver cirrhosis (is_marker_for)	RELN ALAD BECN1	1.07e-03	82	72	3	DOID:5082 (is_marker_for)
Disease	epilepsy (biomarker_via_orthology)	BECN1 ABCB1	1.20e-03	21	72	2	DOID:1826 (biomarker_via_orthology)
Disease	low density lipoprotein cholesterol measurement, response to escitalopram, response to citalopram	RELN SNX13	1.57e-03	24	72	2	EFO_0004611, EFO_0006329, EFO_0007871
Disease	Lewy body dementia, Lewy body dementia measurement	ABRA MYO7A	1.84e-03	26	72	2	EFO_0006792, EFO_0006799
Disease	Generalized seizures	POLG BCHE ALAD	1.96e-03	101	72	3	C0234533
Disease	Clonic Seizures	POLG BCHE ALAD	1.96e-03	101	72	3	C0234535
Disease	Convulsive Seizures	POLG BCHE ALAD	1.96e-03	101	72	3	C0751494
Disease	Seizures, Sensory	POLG BCHE ALAD	1.96e-03	101	72	3	C0751496
Disease	Non-epileptic convulsion	POLG BCHE ALAD	1.96e-03	101	72	3	C0751056
Disease	Atonic Absence Seizures	POLG BCHE ALAD	1.96e-03	101	72	3	C0751123
Disease	Complex partial seizures	POLG BCHE ALAD	1.96e-03	101	72	3	C0149958
Disease	Single Seizure	POLG BCHE ALAD	1.96e-03	101	72	3	C0751110
Disease	Nonepileptic Seizures	POLG BCHE ALAD	1.96e-03	101	72	3	C3495874
Disease	Visual seizure	POLG BCHE ALAD	1.96e-03	101	72	3	C0270824
Disease	Epileptic drop attack	POLG BCHE ALAD	1.96e-03	101	72	3	C0270846
Disease	Vertiginous seizure	POLG BCHE ALAD	1.96e-03	101	72	3	C0422855
Disease	Gustatory seizure	POLG BCHE ALAD	1.96e-03	101	72	3	C0422854
Disease	Seizures, Somatosensory	POLG BCHE ALAD	1.96e-03	101	72	3	C0422850
Disease	Olfactory seizure	POLG BCHE ALAD	1.96e-03	101	72	3	C0422853
Disease	Seizures, Auditory	POLG BCHE ALAD	1.96e-03	101	72	3	C0422852
Disease	Generalized Absence Seizures	POLG BCHE ALAD	1.96e-03	101	72	3	C4505436
Disease	Jacksonian Seizure	POLG BCHE ALAD	1.96e-03	101	72	3	C0022333
Disease	Epileptic Seizures	POLG BCHE ALAD	1.96e-03	101	72	3	C4317109
Disease	Absence Seizures	POLG BCHE ALAD	2.01e-03	102	72	3	C4316903
Disease	Convulsions	POLG BCHE ALAD	2.01e-03	102	72	3	C4048158
Disease	Tonic Seizures	POLG BCHE ALAD	2.01e-03	102	72	3	C0270844
Disease	Seizures, Focal	POLG BCHE ALAD	2.13e-03	104	72	3	C0751495
Disease	Myoclonic Seizures	POLG BCHE ALAD	2.13e-03	104	72	3	C4317123
Disease	Tonic - clonic seizures	POLG BCHE ALAD	2.13e-03	104	72	3	C0494475
Disease	susceptibility to rheumatic fever measurement	RELN RYR3	2.13e-03	28	72	2	EFO_0008416
Disease	atrial fibrillation	FANCC GJA5 SLC27A6 ASAH1 MLLT3	2.15e-03	371	72	5	EFO_0000275
Disease	Neurotoxicity Syndromes	BCHE ABCB1	2.28e-03	29	72	2	C0235032
Disease	Encephalopathy, Toxic	BCHE ABCB1	2.28e-03	29	72	2	C0149504
Disease	Toxic Encephalitis	BCHE ABCB1	2.28e-03	29	72	2	C0154659
Disease	1,5 anhydroglucitol measurement	MGAM RAB3GAP1	2.28e-03	29	72	2	EFO_0008009

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLHTMWNEHFGIGVV	ALG11	391	Q2TAA5
LMISQLLHEWGEEGF	AADAT	301	Q8N5Z0
WMGVMHGYEIEFVFG	BCHE	461	P06276
GDWLIFDNMGADSFH	AZIN1	376	O14977
LHVGDWLVFDNMGAY	AZIN2	376	Q96A70
EGFTHDWMVFVRGPE	MLLT3	26	P42568
EEHMPFWQFFVRLCG	ERGIC2	306	Q96RQ1
MIAQAQHLGGSEEFW	CFAP46	1661	Q8IYW2
LMWAAAHGQIAVVEF	ANKRA2	186	Q9H9E1
IHGRNMDFGVFLGWN	ASAH1	156	Q13510
MSVDAFTIQGHLWQG	CAMSAP3	1221	Q9P1Y5
AIGNAIWEHEVGMRF	ATP8B2	311	P98198
GVAHLWQEFVLEMRF	RAB3GAP1	476	Q15042
EALSWQHGVFVGAAM	PCK1	446	P35558
VDGHFVTMQIWDTAG	RAB9A	51	P51151
GEPFWVLAQAHMFVK	RFT1	136	Q96AA3
FDEVQSFLLHFWQGM	RFX4	221	Q33E94
AMVVAVLAFWHIQGF	PALD1	671	Q9ULE6
FFHAIMRQEIGWFDV	ABCB1	151	P08183
WQSGFFDHGSFKEIM	ACACB	2061	O00763
GFGWNKVAHIMELDV	LARGE1	676	O95461
GVIAALVAWVMSFGH	FFAR2	126	O15552
EFAMLWHGAQAGAFD	ALAD	281	P13716
LFHNQVEFDGIWIDM	MGAM	516	O43451
GLRFFWDNKFDHAMV	BECN1	356	Q14457
AVLWGETVHLFMEAG	MAP3K8	196	P41279
AIFGGEHFMLEETDW	PCYOX1L	111	Q8NBM8
LVGIAWVGGFMHSFA	OR4X2	136	Q8NGF9
LFMQWGQIVDHDLDF	LPO	216	P22079
LWIAAVLGDAHFAGM	POLG	896	P54098
VAVDFGNYHLGVMSW	SLC7A5	311	Q01650
FFIIHGWTMSGIFEN	LIPG	86	Q9Y5X9
FMLGWFAHPVFVDGD	LCT	626	P09848
AHEARLFFMEGWGEG	POMGNT2	186	Q8NAT1
LFFMEGWGEGAHFDL	POMGNT2	191	Q8NAT1
MGGQHNYFGLWVDVD	MEAK7	361	Q6P9B6
QHIEFFWGALEMFTQ	HECTD4	3891	Q9Y4D8
GGIQWHLLAEMYFSD	RELN	1161	P78509
FIRGNMLHVAWVGDS	PPM1E	336	Q8WY54
EEYDQLVWMAIGHQG	NRP1	746	O14786
SIVDWHFGKGFDVMF	DNAH3	2226	Q8TD57
MGDWSFLGNFLEEVH	GJA5	1	P36382
LGEWFIFVEMQGHAY	CPAMD8	201	Q8IZJ3
VFQWYGRMGEIFEEH	DNAH7	656	Q8WXX0
LFIHFGGWAEMVAEQ	FANCC	396	Q00597
HPGQVFGFVCWAVMV	MBOAT4	341	Q96T53
IMGLHDEFLDGQRWI	MAN1A2	236	O60476
EGFTHDWMVFVRGPE	MLLT1	26	Q03111
GFLGFIVWAHHMFTV	MT-CO1	281	P00395
WMVIMGDGIHNFSDG	SLC39A10	671	Q9ULF5
WDAVVGFLHVFAHMQ	RYR2	3941	Q92736
FYHWAMVAVTGGVGV	MFSD12	441	Q6NUT3
KHQFQMEGLLGAWEG	NYNRIN	736	Q9P2P1
VAMAWVGGFLHALIQ	OR4C5	166	Q8NGB2
ANGFIMAIHAAEWVQ	TAS2R39	51	P59534
GQAHLFFWMTVEGYR	SNX13	396	Q9Y5W8
GHGRFQWALFFVLGM	SV2C	146	Q496J9
MAFQDLLGHAGDLWR	SLC22A9	1	Q8IVM8
WDMFGVFFANHPDLR	NDUFS3	171	O75489
IIGIFSGHQWVDMNG	PRSS23	336	O95084
AWHLFGMGNEIDVHT	HEPH	291	Q9BQS7
KHGLVDFEGEMLWQG	ABRA	356	Q8N0Z2
IWQDQGYFVHGLLMF	TMEM86A	86	Q8N2M4
LWDAVVGFLHVFANM	RYR3	3836	Q15413
MHEIGEELIWTGRFF	SLC4A5	481	Q9BY07
EWVNGGALQFHNFVM	PKHD1L1	2661	Q86WI1
LVIHLMRFGFDWESG	USP24	1881	Q9UPU5
QVGWNIFDSMIVFHG	SCN7A	566	Q01118
MADIWEVFNGPFAHR	SEMA3G	346	Q9NS98
LMSNEPDFVHVWFGL	SLC27A6	111	Q9Y2P4
EMEINFHGEWLEVLG	FARS2	276	O95363
AFGVLMWEVFTHGEM	PTK7	991	Q13308
ALWFHNVISEEFGVG	TYW5	231	A2RUC4
EMIRNPGEGHFWQVD	ZRANB3	1006	Q5FWF4
QGDHVWMDLRLGQEF	MYO7A	6	Q13402