Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylcholine binding	CHRM3 CHRNA3 CHRNA5 CHRND	3.77e-07	13	98	4	GO:0042166
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRM3 CHRNA3 CHRNA5 CHRND	4.50e-06	23	98	4	GO:0015464
GeneOntologyMolecularFunction	TIR domain binding	MYD88 PRKCD	2.38e-05	2	98	2	GO:0070976
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRNA3 CHRNA5 CHRND	7.42e-05	17	98	3	GO:0022848
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	CHRM3 CHRNA3 CHRNA5 CHRND	5.08e-04	75	98	4	GO:0098960
GeneOntologyBiologicalProcess	postsynaptic signal transduction	CHRM3 CHRNA3 CHRNA5 STAT3 CHRND	2.03e-05	69	99	5	GO:0098926
GeneOntologyCellularComponent	acetylcholine-gated channel complex	CHRNA3 CHRNA5 CHRND	8.23e-05	18	100	3	GO:0005892
Domain	zf-C2H2	BNC2 ZNF671 ZNF680 PHF20 ZNF423 ZNF200 ZNF595 ZIK1 BCL11B GTF3A ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF664 ZBTB11 ZNF583	1.82e-08	693	98	18	PF00096
Domain	ZINC_FINGER_C2H2_2	BNC2 ZNF671 ZNF680 PHF20 ZNF423 ZNF200 ZNF595 ZIK1 BCL11B GTF3A ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF664 ZBTB11 ZNF583	9.92e-08	775	98	18	PS50157
Domain	ZINC_FINGER_C2H2_1	BNC2 ZNF671 ZNF680 PHF20 ZNF423 ZNF200 ZNF595 ZIK1 BCL11B GTF3A ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF664 ZBTB11 ZNF583	1.03e-07	777	98	18	PS00028
Domain	Znf_C2H2	BNC2 ZNF671 ZNF680 PHF20 ZNF423 ZNF200 ZNF595 ZIK1 BCL11B GTF3A ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF664 ZBTB11 ZNF583	1.75e-07	805	98	18	IPR007087
Domain	ZnF_C2H2	BNC2 ZNF671 ZNF680 PHF20 ZNF423 ZNF200 ZNF595 ZIK1 BCL11B GTF3A ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF664 ZBTB11 ZNF583	1.85e-07	808	98	18	SM00355
Domain	Znf_C2H2-like	BNC2 ZNF671 ZNF680 PHF20 ZNF423 ZNF200 ZIK1 BCL11B GTF3A ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF664 ZBTB11 ZNF583	7.62e-07	796	98	17	IPR015880
Domain	-	ZNF671 ZNF680 ZNF423 ZNF200 ZIK1 BCL11B GTF3A ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF664 ZBTB11 ZNF583	2.44e-06	679	98	15	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF671 ZNF680 ZNF423 ZNF200 ZIK1 BCL11B GTF3A ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF664 ZBTB11 ZNF583	3.19e-06	694	98	15	IPR013087
Domain	zf-C2H2_6	ZNF671 ZNF680 ZNF423 ZNF200 ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZBTB11	5.93e-06	314	98	10	PF13912
Domain	KRAB	ZNF671 ZNF680 ZNF595 ZIK1 ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF583	1.85e-05	358	98	10	PS50805
Domain	KRAB	ZNF671 ZNF680 ZNF595 ZIK1 ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF583	1.85e-05	358	98	10	PF01352
Domain	KRAB	ZNF671 ZNF680 ZNF595 ZIK1 ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF583	2.40e-05	369	98	10	SM00349
Domain	KRAB	ZNF671 ZNF680 ZNF595 ZIK1 ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF583	2.46e-05	370	98	10	IPR001909
Domain	Nicotinic_acetylcholine_rcpt	CHRNA3 CHRNA5 CHRND	7.47e-05	16	98	3	IPR002394
Domain	DUF2075	SLFN5 SLFN11	8.15e-05	3	98	2	IPR018647
Domain	P_trefoil_chordata	TFF1 TFF2	8.15e-05	3	98	2	IPR017994
Domain	DUF2075	SLFN5 SLFN11	8.15e-05	3	98	2	PF09848
Domain	-	CHRNA3 CHRNA5 CHRND	2.30e-04	23	98	3	1.20.120.370
Domain	Acetylcholine_rcpt_TM	CHRNA3 CHRNA5 CHRND	2.30e-04	23	98	3	IPR027361
Domain	AlbA_2	SLFN5 SLFN11	5.63e-04	7	98	2	PF04326
Domain	Schlafen	SLFN5 SLFN11	5.63e-04	7	98	2	IPR029684
Domain	Schlafen_AAA_dom	SLFN5 SLFN11	5.63e-04	7	98	2	IPR007421
Domain	Trefoil	TFF1 TFF2	7.48e-04	8	98	2	PF00088
Domain	P_TREFOIL_1	TFF1 TFF2	7.48e-04	8	98	2	PS00025
Domain	P_trefoil_CS	TFF1 TFF2	7.48e-04	8	98	2	IPR017957
Domain	P_TREFOIL_2	TFF1 TFF2	9.58e-04	9	98	2	PS51448
Domain	PD	TFF1 TFF2	9.58e-04	9	98	2	SM00018
Domain	-	TFF1 TFF2	1.45e-03	11	98	2	4.10.110.10
Domain	Neurotransmitter_ion_chnl_CS	CHRNA3 CHRNA5 CHRND	1.69e-03	45	98	3	IPR018000
Domain	P_trefoil_dom	TFF1 TFF2	1.74e-03	12	98	2	IPR000519
Domain	Neur_chan_memb	CHRNA3 CHRNA5 CHRND	1.81e-03	46	98	3	PF02932
Domain	Neur_chan_LBD	CHRNA3 CHRNA5 CHRND	1.92e-03	47	98	3	PF02931
Domain	NEUROTR_ION_CHANNEL	CHRNA3 CHRNA5 CHRND	1.92e-03	47	98	3	PS00236
Domain	Neurotrans-gated_channel_TM	CHRNA3 CHRNA5 CHRND	1.92e-03	47	98	3	IPR006029
Domain	-	CHRNA3 CHRNA5 CHRND	1.92e-03	47	98	3	2.70.170.10
Domain	Neur_channel	CHRNA3 CHRNA5 CHRND	1.92e-03	47	98	3	IPR006201
Domain	Neur_chan_lig-bd	CHRNA3 CHRNA5 CHRND	1.92e-03	47	98	3	IPR006202
Domain	FN_type2_col-bd	BSPH1 LY75	2.38e-03	14	98	2	IPR000562
Domain	FN2_2	BSPH1 LY75	2.38e-03	14	98	2	PS51092
Domain	PLAC	ADAMTS18 ADAMTSL2	2.38e-03	14	98	2	PF08686
Domain	TIL_dom	MUC19 LRP2	2.38e-03	14	98	2	IPR002919
Domain	fn2	BSPH1 LY75	2.38e-03	14	98	2	PF00040
Domain	FN2_1	BSPH1 LY75	2.38e-03	14	98	2	PS00023
Domain	FN2	BSPH1 LY75	2.38e-03	14	98	2	SM00059
Domain	PLAC	ADAMTS18 ADAMTSL2	4.40e-03	19	98	2	PS50900
Domain	PLAC	ADAMTS18 ADAMTSL2	4.40e-03	19	98	2	IPR010909
Domain	TSP_1	ADAMTS18 C7 ADAMTSL2	4.43e-03	63	98	3	PF00090
Domain	TSP1	ADAMTS18 C7 ADAMTSL2	4.84e-03	65	98	3	SM00209
Domain	TSP1_rpt	ADAMTS18 C7 ADAMTSL2	4.84e-03	65	98	3	IPR000884
Domain	TSP1	ADAMTS18 C7 ADAMTSL2	4.84e-03	65	98	3	PS50092
Domain	ADAM_spacer1	ADAMTS18 ADAMTSL2	6.42e-03	23	98	2	IPR010294
Domain	ADAM_spacer1	ADAMTS18 ADAMTSL2	6.42e-03	23	98	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS18 ADAMTSL2	6.98e-03	24	98	2	IPR013273
Pathway	REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA3 CHRNA5 CHRND	2.50e-05	12	70	3	M48008
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRNA3 CHRNA5 CHRND	4.10e-05	14	70	3	M757
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRNA3 CHRNA5 CHRND	5.11e-05	15	70	3	MM14704
Pubmed	Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.	CHRNA3 CHRNA5 CHRND	9.49e-08	4	101	3	20840187
Pubmed	Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.	CHRNA3 CHRNA5 CHRND	5.13e-06	12	101	3	20584212
Pubmed	CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms are associated with heavy smoking, lung cancer, and chronic obstructive pulmonary disease in a mexican population.	CHRNA3 CHRNA5	8.35e-06	2	101	2	29993116
Pubmed	Polymorphisms of CHRNA3 and CHRNA5: Head and neck cancer and cigarette consumption intensity in a Brazilian population.	CHRNA3 CHRNA5	8.35e-06	2	101	2	31599127
Pubmed	The role of protein kinase C delta activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation.	STAT3 PRKCD	8.35e-06	2	101	2	16418226
Pubmed	Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach.	TFF1 TFF2	8.35e-06	2	101	2	8405856
Pubmed	hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.	TFF1 TFF2	8.35e-06	2	101	2	2303034
Pubmed	Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain.	CD74 CTSS	8.35e-06	2	101	2	19074353
Pubmed	TFF2 deficiency exacerbates weight loss and alters immune cell and cytokine profiles in DSS colitis, and this cannot be rescued by wild-type bone marrow.	TFF1 TFF2	8.35e-06	2	101	2	25324506
Pubmed	The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer.	CHRNA3 CHRNA5	8.35e-06	2	101	2	18957677
Pubmed	CHRNA5 and CHRNA3 polymorphism and lung cancer susceptibility in Palestinian population.	CHRNA3 CHRNA5	8.35e-06	2	101	2	29609626
Pubmed	Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer.	TFF1 TFF2	8.35e-06	2	101	2	16718800
Pubmed	Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.	CHRNA3 CHRNA5	8.35e-06	2	101	2	19132693
Pubmed	Immunoassays of human trefoil factors 1 and 2: measured on serum from patients with inflammatory bowel disease.	TFF1 TFF2	8.35e-06	2	101	2	15115253
Pubmed	Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.	CHRNA3 CHRNA5	8.35e-06	2	101	2	18227835
Pubmed	Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity.	MUC19 CTSS	8.35e-06	2	101	2	12163455
Pubmed	Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers.	CHRNA3 CHRNA5	8.35e-06	2	101	2	21385908
Pubmed	Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk.	CHRNA3 CHRNA5	8.35e-06	2	101	2	20564069
Pubmed	CHRNA5/CHRNA3 Locus Associates with Increased Mortality among Smokers.	CHRNA3 CHRNA5	8.35e-06	2	101	2	26751916
Pubmed	Hepatitis C virus-mediated inhibition of cathepsin S increases invariant-chain expression on hepatocyte surface.	CD74 CTSS	8.35e-06	2	101	2	22761382
Pubmed	In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs.	CHRNA3 CHRNA5	8.35e-06	2	101	2	15716100
Pubmed	Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland.	CHRNA3 CHRNA5	8.35e-06	2	101	2	27127891
Pubmed	Four SNPs in the CHRNA3/5 alpha-neuronal nicotinic acetylcholine receptor subunit locus are associated with COPD risk based on meta-analyses.	CHRNA3 CHRNA5	8.35e-06	2	101	2	25051068
Pubmed	A second genetic variant on chromosome 15q24-25.1 associates with lung cancer.	CHRNA3 CHRNA5	8.35e-06	2	101	2	20395203
Pubmed	Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation.	STAT3 PRKCD	8.35e-06	2	101	2	11335711
Pubmed	MEN2A-RET-induced cellular transformation by activation of STAT3.	RET STAT3	8.35e-06	2	101	2	11536047
Pubmed	A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes.	CHRNA3 CHRNA5	8.35e-06	2	101	2	21748402
Pubmed	Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine.	CHRNA3 CHRNA5	8.35e-06	2	101	2	36078193
Pubmed	CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.	CHRNA3 CHRNA5	8.35e-06	2	101	2	24588897
Pubmed	Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity.	CHRNA3 CHRNA5	8.35e-06	2	101	2	20725741
Pubmed	A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction.	CHRNA3 CHRNA5	8.35e-06	2	101	2	20643934
Pubmed	Alpha-nicotinic acetylcholine receptor and tobacco smoke exposure: effects on bronchial hyperresponsiveness in children.	CHRNA3 CHRNA5	8.35e-06	2	101	2	22017462
Pubmed	In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression.	CHRNA3 CHRNA5	8.35e-06	2	101	2	21858091
Pubmed	Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk.	CHRNA3 CHRNA5	8.35e-06	2	101	2	21559498
Pubmed	Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort.	CHRNA3 CHRNA5	8.35e-06	2	101	2	22223462
Pubmed	Activation of signal transducer and activator of transcription 3 by oncogenic RET/PTC (rearranged in transformation/papillary thyroid carcinoma) tyrosine kinase: roles in specific gene regulation and cellular transformation.	RET STAT3	8.35e-06	2	101	2	12637586
Pubmed	Multilayer OMIC Data in Medullary Thyroid Carcinoma Identifies the STAT3 Pathway as a Potential Therapeutic Target in RETM918T Tumors.	RET STAT3	8.35e-06	2	101	2	27620278
Pubmed	Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese.	CHRNA3 CHRNA5	8.35e-06	2	101	2	19005185
Pubmed	CHRNA5/CHRNA3 gene cluster is a risk factor for lumbar disc herniation: a case-control study.	CHRNA3 CHRNA5	8.35e-06	2	101	2	31362771
Pubmed	Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer.	CHRNA3 CHRNA5	8.35e-06	2	101	2	19641473
Pubmed	Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties.	CHRNA3 CHRNA5 CHRND	8.45e-06	14	101	3	19059502
Pubmed	Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse.	CHRNA3 CHRNA5 CHRND	1.05e-05	15	101	3	8838678
Pubmed	Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.	CHRNA3 CHRNA5 CHRND	1.30e-05	16	101	3	19259974
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF680 ZNF595 ZNF684 ZNF718 ZBTB11 ZNF583	1.54e-05	181	101	6	37372979
Pubmed	No evidence for association between 19 cholinergic genes and bipolar disorder.	CHRM3 CHRNA3 CHRNA5	2.23e-05	19	101	3	17373692
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	KBTBD3 BNC2 PHF20 ZNF423 ZNF595 STAT3 ZDHHC20 GTF3A ZNF718 ZNF43 ZNF790	2.37e-05	808	101	11	20412781
Pubmed	Association of CHRNA5-A3-B4 variation with esophageal squamous cell carcinoma risk and smoking behaviors in a Chinese population.	CHRNA3 CHRNA5	2.50e-05	3	101	2	23844051
Pubmed	Differential Expression of TFF Genes and Proteins in Breast Tumors.	TFF1 TFF2	2.50e-05	3	101	2	30431719
Pubmed	Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.	CHRNA3 CHRNA5	2.50e-05	3	101	2	25471942
Pubmed	Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs.	CHRNA3 CHRNA5	2.50e-05	3	101	2	19671882
Pubmed	Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects.	CHRNA3 CHRNA5	2.50e-05	3	101	2	22101982
Pubmed	The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies.	CHRNA3 CHRNA5	2.50e-05	3	101	2	24750073
Pubmed	Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study.	CHRNA3 CHRNA5	2.50e-05	3	101	2	21646606
Pubmed	ATP drives lamina propria T(H)17 cell differentiation.	MYD88 STAT3	2.50e-05	3	101	2	18716618
Pubmed	Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula-interpeduncular nucleus pathway in mice.	CHRNA3 CHRNA5	2.50e-05	3	101	2	38902419
Pubmed	Combined analysis of CHRNA5, CHRNA3 and CYP2A6 in relation to adolescent smoking behaviour.	CHRNA3 CHRNA5	2.50e-05	3	101	2	21765098
Pubmed	Urine Trefoil Factors as Prognostic Biomarkers in Chronic Kidney Disease.	TFF1 TFF2	2.50e-05	3	101	2	29850501
Pubmed	Pleiotropic effects of Chr15q25 nicotinic gene cluster and the relationship between smoking, cognition and ADHD.	CHRNA3 CHRNA5	2.50e-05	3	101	2	27302872
Pubmed	A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.	CHRNA3 CHRNA5	2.50e-05	3	101	2	19429911
Pubmed	Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight.	CHRNA3 CHRNA5	2.50e-05	3	101	2	22956269
Pubmed	Association between Promoter Polymorphisms of TFF1, TFF2, and TFF3 and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population.	TFF1 TFF2	2.50e-05	3	101	2	26240479
Pubmed	A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.	CHRNA3 CHRNA5	2.50e-05	3	101	2	18618000
Pubmed	Meta-analysis and imputation refines the association of 15q25 with smoking quantity.	CHRNA3 CHRNA5	2.50e-05	3	101	2	20418889
Pubmed	In vivo control of endosomal architecture by class II-associated invariant chain and cathepsin S.	CD74 CTSS	2.50e-05	3	101	2	16094690
Pubmed	The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments.	CD74 CTSS	2.50e-05	3	101	2	28550201
Pubmed	Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach.	CHRNA3 CHRNA5	2.50e-05	3	101	2	11606319
Pubmed	Association of a variant in the CHRNA5-A3-B4 gene cluster region to heavy smoking in the Italian population.	CHRNA3 CHRNA5	2.50e-05	3	101	2	21248747
Pubmed	Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.	CHRNA3 CHRNA5	2.50e-05	3	101	2	18414406
Pubmed	Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass.	MSTN STAT3	2.50e-05	3	101	2	24011072
Pubmed	Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits.	CHRNA3 CHRNA5	2.50e-05	3	101	2	1572664
Pubmed	GDNF family ligand dependent STAT3 activation is mediated by specific alternatively spliced isoforms of GFRα2 and RET.	RET STAT3	2.50e-05	3	101	2	23872421
Pubmed	IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells.	STAT3 CTSS	2.50e-05	3	101	2	16286017
Pubmed	Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice.	CHRNA3 CHRNA5	2.50e-05	3	101	2	22459873
Pubmed	Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence.	CHRNA3 CHRNA5	2.50e-05	3	101	2	30453884
Pubmed	Examination of rare missense variants in the CHRNA5-A3-B4 gene cluster to level of response to alcohol in the San Diego Sibling Pair study.	CHRNA3 CHRNA5	2.50e-05	3	101	2	23458267
Pubmed	Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients.	CHRNA3 CHRNA5	2.50e-05	3	101	2	19733931
Pubmed	The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer.	CHRNA3 CHRNA5	2.50e-05	3	101	2	20685379
Pubmed	Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes.	CHRNA3 CHRNA5	2.50e-05	3	101	2	22336398
Pubmed	Clinicopathologic significance of MYD88 L265P mutation and expression of TLR4 and P-STAT3 in primary central nervous system diffuse large B-cell lymphomas.	MYD88 STAT3	2.50e-05	3	101	2	33079297
Pubmed	Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes.	CHRNA3 CHRNA5	2.50e-05	3	101	2	18996504
Pubmed	Association of IREB2 and CHRNA3/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population.	CHRNA3 CHRNA5	2.50e-05	3	101	2	22914670
Pubmed	Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males.	CHRNA3 CHRNA5	2.50e-05	3	101	2	26942719
Pubmed	Overexpression of α3/α5/β4 nicotinic receptor subunits modifies impulsive-like behavior.	CHRNA3 CHRNA5	2.50e-05	3	101	2	22024278
Pubmed	IREB2, CHRNA5, CHRNA3, FAM13A & hedgehog interacting protein genes polymorphisms & risk of chronic obstructive pulmonary disease in Tatar population from Russia.	CHRNA3 CHRNA5	2.50e-05	3	101	2	28474623
Pubmed	An exploratory study on the CHRNA3-CHRNA5-CHRNB4 cluster, smoking, and Parkinson's disease.	CHRNA3 CHRNA5	2.50e-05	3	101	2	21228559
Pubmed	Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression.	TFF1 TFF2	2.50e-05	3	101	2	9043862
Pubmed	Reversal of multidrug resistance by icaritin in doxorubicin-resistant human osteosarcoma cells.	ABCC1 STAT3	2.50e-05	3	101	2	29425587
Pubmed	Role of genetic variants in the CHRNA5-CHRNA3-CHRNB4 cluster in nicotine dependence risk: importance of gene-environment interplay.	CHRNA3 CHRNA5	2.50e-05	3	101	2	19696770
Pubmed	The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations.	CHRNA3 CHRNA5	2.50e-05	3	101	2	27758088
Pubmed	Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium.	CHRNA3 CHRNA5	2.50e-05	3	101	2	25293386
Pubmed	Gene variance in the nicotinic receptor cluster (CHRNA5-CHRNA3-CHRNB4) predicts death from cardiopulmonary disease and cancer in smokers.	CHRNA3 CHRNA5	2.50e-05	3	101	2	26689306
Pubmed	The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.	TFF1 TFF2	2.50e-05	3	101	2	9070946
Pubmed	Role of CHRNA5-A3 genetic Locus variants and developing drug for chronic obstructive pulmonary disease.	CHRNA3 CHRNA5	2.50e-05	3	101	2	23061658
Pubmed	Requirement for invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation.	CD74 CTSS	2.50e-05	3	101	2	21576321
Pubmed	The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.	CHRNA3 CHRNA5	2.50e-05	3	101	2	19706762
Pubmed	Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers.	CHRNA3 CHRNA5	2.50e-05	3	101	2	25474695
Pubmed	Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine.	CHRNA3 CHRNA5	2.50e-05	3	101	2	19010884
Pubmed	In search of causal variants: refining disease association signals using cross-population contrasts.	CHRNA3 CHRNA5	2.50e-05	3	101	2	18759969
Pubmed	Trefoil factor family (TFF)-domain peptides in the mouse: embryonic gastrointestinal expression and wounding response.	TFF1 TFF2	2.50e-05	3	101	2	10350130
Pubmed	Trefoil factor family peptides in normal and diseased human pancreas.	TFF1 TFF2	2.50e-05	3	101	2	22286382
Interaction	CLGN interactions	NPC1 ABCC1 RET CHRNA3 CHRNA5 TXNDC15 SPRING1 ALDH3B2 CTSS	1.68e-06	235	95	9	int:CLGN
Cytoband	12q24.22	LINC00173 SPRING1	2.09e-04	10	100	2	12q24.22
Cytoband	3q12.3	NXPE3 ZBTB11	5.53e-04	16	100	2	3q12.3
Cytoband	19q13.43	ZNF671 ZIK1 ZNF583	9.31e-04	87	100	3	19q13.43
Cytoband	15q24	CHRNA3 CHRNA5	9.60e-04	21	100	2	15q24
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	ABCC1 RHBDF1 MPV17L ZNF200 ZNF75A	2.46e-03	426	100	5	chr16p13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	BNC2 ZNF671 ZNF680 ZNF423 ZNF200 ZNF595 ZIK1 BCL11B GTF3A ZNF684 ZNF718 ZNF43 ZNF790 ZNF75A ZNF664 ZBTB11 ZNF583	2.77e-09	718	73	17	28
GeneFamily	Cholinergic receptors nicotinic subunits	CHRNA3 CHRNA5 CHRND	3.41e-05	16	73	3	173
GeneFamily	Schlafen family	SLFN5 SLFN11	3.33e-04	7	73	2	1110
GeneFamily	Cadherin related	CDHR5 RET	2.10e-03	17	73	2	24
GeneFamily	CD molecules\|Mucins	MUC19 MUC3A	3.21e-03	21	73	2	648
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMA3 TM6SF2 CHRM3 TFF1 TFF2 MUC3A	5.22e-06	195	100	6	23ab7e2a419377c05bab0e92a2457afbcd3d9e07
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RYR3 BCL11B ADAMTS18 C7 MUC3A	1.30e-05	134	100	5	cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SYNDIG1L RYR3 BCL11B KCNA4 MUC3A	3.16e-05	161	100	5	ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCell	Striatum-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Notum_(Notum)--\|Striatum / BrainAtlas - Mouse McCarroll V32	GPAM OPN1SW TFF2 ADAMTS18	3.35e-05	81	100	4	c9145c994abcf49e5492270b18b0580a3d771ccf
ToppCell	Striatum-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Notum_(Notum)-\|Striatum / BrainAtlas - Mouse McCarroll V32	GPAM OPN1SW TFF2 ADAMTS18	3.35e-05	81	100	4	34d2a2c30c749bd2ad447dfb1e43444953d9b154
ToppCell	Striatum-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Notum_(Notum)\|Striatum / BrainAtlas - Mouse McCarroll V32	GPAM OPN1SW TFF2 ADAMTS18	3.35e-05	81	100	4	f84bfa55c6b9548f8829b16a145690d207a7bfc1
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SYNDIG1L BNC2 RET CHRNA3 CHRNA5	3.65e-05	166	100	5	6a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MMS22L ALG8 CD74 ZNF583 CTSS	3.87e-05	168	100	5	93b7138f17aa14a6398c9b4ea7237781a0e19a66
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MMS22L ALG8 CD74 ZNF583 CTSS	3.87e-05	168	100	5	e393553208617a023f1646169c892a87c95db3f5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF423 CHRM3 CHRND BCL11B SLC37A4	3.87e-05	168	100	5	1dfe87129fdf4cef71dbc17cf39692f0b8dc3345
ToppCell	facs-Kidney\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPV17L CDHR5 SLC13A1 LRP2 CTSS	3.87e-05	168	100	5	d2f17a470e04f8f0edb111894027bcfc6ee1a12f
ToppCell	mild_COVID-19_(asymptomatic)-RBC\|World / disease group, cell group and cell class (v2)	ABCC1 ZNF680 CENPL TMEM116 ZNF200	3.98e-05	169	100	5	2bda6ab3f32e05cb7daf91eb7c39b4fcc9ae91bb
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF423 DNAAF10 LPAR6 ADAMTS18 CD74	3.98e-05	169	100	5	7c994653b0d629dfb046755d6b678452de0a15d2
ToppCell	mild_COVID-19_(asymptomatic)-RBC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	ABCC1 ZNF680 CENPL TMEM116 ZNF200	4.21e-05	171	100	5	78491478ba65bad45238fe114f5251b2adea323d
ToppCell	10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-NK_progenitor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CALCR TMEM116 SLFN5 PTGDR BCL11B	4.32e-05	172	100	5	a126dacd94939851de1403d30f0b63eaad48bfa1
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RNF217 ZIK1 TMTC3 ALG8 NEIL3	4.45e-05	173	100	5	12f779b8dce79431b2d1002ba524dd3f9566aeb0
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF680 GPAM PTGDR ZIK1 CRBN	4.57e-05	174	100	5	ccc79febfcf588d8294ffc712338be96de8a5033
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC19 LRP2 CD74 C7 CTSS	4.70e-05	175	100	5	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	STXBP5L RET CHRNA3 SLC46A3 KCNA4	5.09e-05	178	100	5	38ffbd01230c99f52274424ee6c172381daffc73
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP5L RYR3 KCNA4 PIK3C2G LRP2	5.96e-05	184	100	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHRNA3 ZDHHC20 CD74 SLFN11 CTSS	5.96e-05	184	100	5	840fac463665ed18752f402f7d1ef2e5052bdf74
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RET CSMD2 CHRNA3 RYR3 CD74	5.96e-05	184	100	5	658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP5L RYR3 KCNA4 PIK3C2G LRP2	5.96e-05	184	100	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP5L RYR3 KCNA4 PIK3C2G LRP2	5.96e-05	184	100	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BNC2 CSMD2 CHRNA3 C7 ADAMTSL2	6.11e-05	185	100	5	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SCAMP2 LPAR6 PRKCD CD74 CTSS	6.93e-05	190	100	5	4498705c5c1c7ba88a26fd2f412cf1aadd0f572a
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|368C / Donor, Lineage, Cell class and subclass (all cells)	CALCR STXBP5L LPAR6 CD74 CTSS	6.93e-05	190	100	5	cbba3d94a4c3e0b0d14f3b7c60dba5d6e097c5e3
ToppCell	(210)_NKT_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	BNC2 SLFN5 PTGDR BCL11B SPRING1	7.28e-05	192	100	5	08dc0c019c594da7b9944db8fd706aa7780e6ae9
ToppCell	(21)_NKT_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	BNC2 SLFN5 PTGDR BCL11B SPRING1	7.28e-05	192	100	5	b0a573ddde2978485a857b8261ee1ee5ef68ecef
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Thalamus / BrainAtlas - Mouse McCarroll V32	CWH43 KCNA4 PIK3C2G PRKCD	7.65e-05	100	100	4	20675fc2ffc5ab63047d38da083b50d470f3db19
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6\|Thalamus / BrainAtlas - Mouse McCarroll V32	CWH43 KCNA4 PIK3C2G PRKCD	7.65e-05	100	100	4	1de3895e16f14ff32b901b18ce14d965afaa7e76
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora\|Thalamus / BrainAtlas - Mouse McCarroll V32	CWH43 KCNA4 PIK3C2G PRKCD	7.65e-05	100	100	4	ff1bdb511700a041a90034d1d30dfc25f51d6c82
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SCAMP2 LPAR6 PRKCD CD74 CTSS	7.83e-05	195	100	5	b6bf75669f267ecdc96818c7022db852e37a9fe1
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMA3 CDHR5 TM6SF2 CHRM3 MUC3A	7.83e-05	195	100	5	e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCell	3'-Child09-12\|3' / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDHR5 TM6SF2 SLC13A1 CD74 MUC3A	8.03e-05	196	100	5	1bcc4ffff51cdb6211824686c2422c43b09e24b2
ToppCell	Enterocyte\|World / shred on cell type and cluster	CDHR5 TM6SF2 SLC46A3 CD74 MUC3A	8.22e-05	197	100	5	1dd980fd066aef21694395a4b69df938501d9631
ToppCell	Sigmoid-B_cell-B_cell_IgG_Plasma\|B_cell / Region, Cell class and subclass	CWH43 SCAMP2 RYR3 CTSS CRBN	8.42e-05	198	100	5	305d7ae9b070ac7211638a5282374c02bf13af40
ToppCell	mLN-B_cell-B_cell_IgA_Plasma\|B_cell / Region, Cell class and subclass	SLFN5 BCL11B TXNDC5 LPAR6 GPRC5D	8.62e-05	199	100	5	09494953bc7fff63cf2763ea89fca7abb97c186f
ToppCell	Control_saline-Hematopoietic_Myeloid-Dendritic_cells\|Control_saline / Treatment groups by lineage, cell group, cell type	ACRBP SLC46A3 PRKCD CD74 CTSS	8.83e-05	200	100	5	1559844b3116d41a69081e4ee89e64744a760181
Disease	Smoking as a quantitative trait locus 3	CHRNA3 CHRNA5	1.05e-05	2	96	2	cv:C3150168
Disease	–	CHRNA3 CHRNA5	1.05e-05	2	96	2	612052
Disease	chronic obstructive pulmonary disease (is_implicated_in)	ABCC1 CHRM3 CHRNA3 CHRNA5	5.41e-05	63	96	4	DOID:3083 (is_implicated_in)
Disease	nicotine dependence (is_implicated_in)	CHRNA3 CHRNA5	1.56e-04	6	96	2	DOID:0050742 (is_implicated_in)
Disease	free cholesterol measurement	GPAM TM6SF2 LIPG PPP6R2	5.16e-04	113	96	4	EFO_0008591
Disease	TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)	CHRNA3 CHRNA5	6.77e-04	12	96	2	C1861063
Disease	C-C motif chemokine 16 measurement	SLFN5 SLFN11	6.77e-04	12	96	2	EFO_0008044
Disease	vitamin D measurement	ZNF680 GPAM TM6SF2 LIPG BSPH1 PPP6R2	8.18e-04	336	96	6	EFO_0004631
Disease	response to bronchodilator, FEV/FEC ratio	BNC2 MMS22L CHRM3 CHRNA3 CHRNA5 FAM227A CD74 C7 SLC37A4	8.87e-04	766	96	9	EFO_0004713, GO_0097366
Disease	cholesterol in IDL measurement	GPAM TM6SF2 LIPG	9.04e-04	58	96	3	EFO_0021899
Disease	membranous glomerulonephritis (biomarker_via_orthology)	LRP2 C7	9.29e-04	14	96	2	DOID:10976 (biomarker_via_orthology)
Disease	Tobacco Dependence	CHRNA3 CHRNA5	9.29e-04	14	96	2	C0040332
Disease	Nicotine Dependence	CHRNA3 CHRNA5	9.29e-04	14	96	2	C0028043
Disease	Nicotine Use Disorder	CHRNA3 CHRNA5	9.29e-04	14	96	2	C0376384
Disease	total lipids in IDL	GPAM TM6SF2 LIPG	9.98e-04	60	96	3	EFO_0022161
Disease	lung small cell carcinoma (is_marker_for)	CHRNA3 CHRNA5	1.22e-03	16	96	2	DOID:5409 (is_marker_for)
Disease	congenital myasthenic syndrome (implicated_via_orthology)	CHRNA3 CHRND	1.22e-03	16	96	2	DOID:3635 (implicated_via_orthology)
Disease	emphysema pattern measurement	CHRNA3 CHRNA5	1.73e-03	19	96	2	EFO_0005850
Disease	lung cancer (is_implicated_in)	MYD88 CHRNA3 CHRNA5	1.83e-03	74	96	3	DOID:1324 (is_implicated_in)
Disease	non-high density lipoprotein cholesterol measurement	NPC1 BNC2 GPAM TM6SF2 STAT3 KCNA4 LIPG PPP6R2	2.29e-03	713	96	8	EFO_0005689
Disease	Acute Lung Injury	TFF1 TFF2	2.32e-03	22	96	2	C0242488
Disease	lipoprotein measurement, phospholipid measurement	GPAM TM6SF2 LIPG	2.72e-03	85	96	3	EFO_0004639, EFO_0004732
Disease	intermediate density lipoprotein measurement	GPAM TM6SF2 LIPG	2.90e-03	87	96	3	EFO_0008595
Disease	non-alcoholic fatty liver disease	GPAM TM6SF2 KCNA4 PRKCD	2.99e-03	182	96	4	EFO_0003095
Disease	paracentral lobule volume measurement	STXBP5L C7	2.99e-03	25	96	2	EFO_0010317
Disease	cigarettes per day measurement	MMS22L CALCR ZNF423 RET CHRNA3 CHRNA5	3.12e-03	438	96	6	EFO_0006525
Disease	lipid measurement, lipoprotein measurement	TM6SF2 LIPG PPP6R2	3.19e-03	90	96	3	EFO_0004529, EFO_0004732
Disease	colon adenocarcinoma (is_implicated_in)	MYD88 STAT3	3.24e-03	26	96	2	DOID:234 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
AVYTSFCCCFPQSWF	FAM227A	251	F5H4B4
CPISVTYFPFDWQNC	CHRND	151	Q07001
QWSAKKPGCVFSCFF	CSMD2	566	Q7Z408
FPFDYQNCTMKFGSW	CHRNA3	166	P32297
WPAYFKVPCCGVDTS	BNC2	26	Q6ZN30
CWDDTPAGVLSYQFC	CALCR	81	P30988
CSNLPYASWFESFCQ	ACRBP	91	Q8NEB7
FCDSCIPKTFWNLGY	CHRM3	516	P20309
FPGYAWTVAQCKICA	CRBN	381	Q96SW2
VAWFCYFNAGQTCVA	ALDH3B2	151	P48448
WFLPCTFSDGYVCIQ	CDHR5	236	Q9HBB8
YVFASPGCKKWDTCA	BPNT1	236	O95861
TEPKICNAFSCPAYW	ADAMTS18	921	Q8TE60
FGKFVQYCPGTWCFI	PTGDR	171	Q13258
FYSCAGWCVVTFILG	PIK3C2G	1016	O75747
DQTWCYCPVKNDFFL	KBTBD3	371	Q8NAB2
GPCDIVYLWSFLNCF	HHATL	381	Q9HCP6
GFYSFPICQACWCSA	LAMA3	526	Q16787
CGFFEWADLSFPFCN	NEIL3	541	Q8TAT5
CRDTYQFFCPDWTCV	ERVS71-1	141	P61550
QFFCPDWTCVTLATY	ERVS71-1	146	P61550
FGQPTFCSVCKDFVW	PRKCD	166	Q05655
TEWCKPPYFSCAVDN	MMS22L	21	Q6ZRQ5
GFNYTVFDCKWVPCS	DNAAF10	16	Q96MX6
SVQCWIGIPFCATYV	OR52A4P	26	A6NMU1
AQTFPCDSNPYCKAW	MUC19	1451	Q7Z5P9
QWDGLKCQCPSTFYG	MUC3A	2991	Q02505
FGTILVYTCEKSCWP	PDCD2L	321	Q9BRP1
ITVCDYTNPCTKSWF	MYD88	271	Q99836
PLLCFWSLCYCFAAG	LIPG	6	Q9Y5X9
GWQSFPASLSCYKVF	LY75	646	O60449
YQCFKVSSWTECPPT	LY6L	31	H3BQJ8
ESTCFERPCFKWYTS	ADAMTSL2	846	Q86TH1
EACFENFPEATWKTY	LPAR6	166	P43657
YFKCQSEGQCIPNSW	LRP2	71	P98164
YIPRFWTFETGCTVC	PLOD1	256	Q02809
CPAQVFSQSCVWYGE	NPC1	16	O15118
VFGVKTCCTDWGQFF	SLC37A4	236	O43826
SKGNRTDSCCWYPYV	CHRNA5	226	P30532
YICTTCKQPFNSAWF	BCL11B	221	Q9C0K0
FCSAEDFANCVFPFW	BSPH1	81	Q075Z2
IGTWFQKTFDCYFSP	CENPL	196	Q8N0S6
FVSKATFCGPCENWK	GPRC5D	186	Q9NZD1
DFYAPWSECNGCTKT	C7	31	P10643
HCCPWIYFDGKLFQS	FAM120C	846	Q9NX05
SEIGCYQGFAFAWKC	LTO1	51	Q8WV07
FQSCSPGWCSAFYEA	KNDC1	1086	Q76NI1
KYQGSCGACWAFSAV	CTSS	131	P25774
SIGYCWCVFPNGTEV	CD74	246	P04233
CRCLNFGSWFTFSFP	SLC13A1	276	Q9BZW2
WAKFTDFQPFCCSES	PPP6R2	751	O75170
YFAVSPASPCAWNVC	PPP6R2	796	O75170
CWSDCRFYPAKVTAV	PHF20	96	Q9BVI0
QCSCGPDWYTVGTKY	OPN1SW	181	P03999
ACADISINFWYGFCV	OR52H1	196	Q8NGJ2
KCFQNTVLVWVPCFY	ABCC1	31	P33527
EIFFCAWCTAFKFVP	CWH43	326	Q9H720
CCFWPLGIAAFYFSQ	SYNDIG1L	171	A6NDD5
VNVPSTKQYCCDGCW	SPRING1	106	Q9H741
GAVQSLFPWFCFCFQ	TBC1D21	231	Q8IYX1
CNFTDLYTGEPWFCF	NXPE3	236	Q969Y0
CCRYPLTVDFEAFGW	MSTN	281	O14793
CCYSCTPQSWDKFFN	GPAM	66	Q9HCL2
WCEFLTCIPFTDKFC	RHBDF1	831	Q96CC6
TFWGACFAYIVDQCK	SLC46A3	146	Q7Z3Q1
RCFYIFVKSWSSGPF	SLFN11	101	Q7Z7L1
WCPVKPCFYQDFSTE	SCAMP2	126	O15127
YKIQCPTCQFVWCFK	RNF217	371	Q8TC41
YWCPESRIFCVSGVS	STXBP5L	521	Q9Y2K9
CCFDDTVRGVPWCFY	TFF1	56	P04155
EVCCEFVFPFTSWKV	ALG8	471	Q9BVK2
GGSEFKFWFCYCLIA	LINC00173	116	Q6ZV60
KPYECSQCGKTFTWN	ZNF684	241	Q5T5D7
PYTCEECGKAFNWSS	ZNF718	366	Q3SXZ3
PFTCEECGKAFNWSS	ZNF595	591	Q8IYB9
VKPFQCQFCDKCYSW	ZBTB11	791	O95625
CPWVNNCVGFSNYKF	ZDHHC20	156	Q5W0Z9
PYLCGACGKQFWFST	ZNF671	191	Q8TAW3
LACCTLYGISWQFDP	TMEM11	116	P17152
AYAGVCGFLWATFIC	MPV17L	151	Q2QL34
CWDFFPAGDCFRKQY	RYR3	4851	Q15413
GVNYSGCQITWAKFC	STAT3	536	P40763
PWECNECGKFFSQTS	ZIK1	266	Q3SY52
CCFSNFIFEVPWCFF	TFF2	106	Q03403
NGSDCTLVLFYTPWC	TXNDC15	206	Q96J42
FYPVAFFCCWGPAVI	TMEM116	141	Q8NCL8
ECQWPGCARVYFSFF	RET	136	P07949
WYTCPLCGKQFNESS	ZNF200	251	P98182
KYAWSGYVIECPNCG	ZFYVE1	501	Q9HBF4
YKCEECGKAFNWPST	ZNF43	426	P17038
PYECKQCGKTFTWAS	ZNF790	421	Q6PG37
PYKCYECGKAFNWSS	ZNF664	86	Q8N3J9
TFIKFYAPWCGHCKT	TXNDC5	341	Q8NBS9
ICSFPDCSANYSKAW	GTF3A	41	Q92664
GQGWTKVVYSCPYCS	ZNF423	401	Q2M1K9
YRVPEDTWGCFFVCN	TM6SF2	326	Q9BZW4
PYKCSWCGKSFSQNT	ZNF75A	216	Q96N20
VTACYWNSLFCGFVF	TMTC3	16	Q6ZXV5
TFCCKFASFPEGSWE	PVRIG	131	Q6DKI7
SYKCDECGNVFNWPA	ZNF680	461	Q8NEM1
FCCAVFAKVPSSWQV	SLFN5	301	Q08AF3
CPDWEYVFKNSEFSS	ZNF583	76	Q96ND8
VGKTFFFSCWCHPLF	nan	46	Q9UFV3
WFSFEFVVRCFACPS	KCNA4	381	P22459