Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	latrotoxin receptor activity	ADGRL1 ADGRL2	6.40e-06	2	51	2	GO:0016524
GeneOntologyMolecularFunction	Toll-like receptor 2 binding	TLR1 TLR6	3.82e-05	4	51	2	GO:0035663
GeneOntologyMolecularFunction	lipopeptide binding	TLR1 TLR6	2.84e-04	10	51	2	GO:0071723
GeneOntologyMolecularFunction	NAD+ nucleotidase, cyclic ADP-ribose generating	TLR1 TLR6	7.50e-04	16	51	2	GO:0061809
GeneOntologyBiologicalProcess	detection of bacterial lipopeptide	TLR1 TLR6	1.66e-05	3	49	2	GO:0070340
GeneOntologyBiologicalProcess	detection of bacterial lipoprotein	TLR1 TLR6	3.31e-05	4	49	2	GO:0042494
GeneOntologyBiologicalProcess	positive regulation of sterol transport	COMMD1 ABCA5 ABCA8	1.17e-04	40	49	3	GO:0032373
GeneOntologyBiologicalProcess	positive regulation of cholesterol transport	COMMD1 ABCA5 ABCA8	1.17e-04	40	49	3	GO:0032376
GeneOntologyBiologicalProcess	rRNA transcription	ERCC6 GTF3C1 UBTF	1.78e-04	46	49	3	GO:0009303
GeneOntologyBiologicalProcess	transcription elongation by RNA polymerase I	ERCC6 UBTF	1.97e-04	9	49	2	GO:0006362
GeneOntologyBiologicalProcess	cellular response to bacterial lipoprotein	TLR1 TLR6	2.46e-04	10	49	2	GO:0071220
GeneOntologyBiologicalProcess	cellular response to bacterial lipopeptide	TLR1 TLR6	2.46e-04	10	49	2	GO:0071221
GeneOntologyBiologicalProcess	response to bacterial lipopeptide	TLR1 TLR6	2.46e-04	10	49	2	GO:0070339
GeneOntologyBiologicalProcess	response to bacterial lipoprotein	TLR1 TLR6	3.00e-04	11	49	2	GO:0032493
Domain	Latrophilin	ADGRL1 ADGRL2 ADGRL3	1.81e-08	3	50	3	PF02354
Domain	GPCR_2_latrophilin_rcpt_C	ADGRL1 ADGRL2 ADGRL3	1.81e-08	3	50	3	IPR003334
Domain	Lectin_gal-bd_dom	ADGRL1 ADGRL2 ADGRL3	1.80e-07	5	50	3	IPR000922
Domain	Gal_Lectin	ADGRL1 ADGRL2 ADGRL3	1.80e-07	5	50	3	PF02140
Domain	SUEL_LECTIN	ADGRL1 ADGRL2 ADGRL3	1.80e-07	5	50	3	PS50228
Domain	GPCR_2_latrophilin	ADGRL1 ADGRL2 ADGRL3	1.80e-07	5	50	3	IPR003924
Domain	GAIN_dom_N	ADGRL1 ADGRL2 ADGRL3	2.93e-06	11	50	3	IPR032471
Domain	GAIN	ADGRL1 ADGRL2 ADGRL3	2.93e-06	11	50	3	PF16489
Domain	Olfac-like_dom	ADGRL1 ADGRL2 ADGRL3	5.07e-06	13	50	3	IPR003112
Domain	OLF	ADGRL1 ADGRL2 ADGRL3	5.07e-06	13	50	3	SM00284
Domain	OLF	ADGRL1 ADGRL2 ADGRL3	5.07e-06	13	50	3	PF02191
Domain	OLF	ADGRL1 ADGRL2 ADGRL3	5.07e-06	13	50	3	PS51132
Domain	NPIP	NPIPB8 NPIPB9 NPIPB6	6.44e-06	14	50	3	IPR009443
Domain	HormR	ADGRL1 ADGRL2 ADGRL3	3.98e-05	25	50	3	SM00008
Domain	HRM	ADGRL1 ADGRL2 ADGRL3	5.64e-05	28	50	3	PF02793
Domain	Toll-like_receptor	TLR1 TLR6	6.99e-05	5	50	2	IPR017241
Domain	GPS	ADGRL1 ADGRL2 ADGRL3	1.02e-04	34	50	3	SM00303
Domain	GPCR_2_secretin-like_CS	ADGRL1 ADGRL2 ADGRL3	1.02e-04	34	50	3	IPR017983
Domain	GPS	ADGRL1 ADGRL2 ADGRL3	1.11e-04	35	50	3	PF01825
Domain	GPS	ADGRL1 ADGRL2 ADGRL3	1.21e-04	36	50	3	PS50221
Domain	GPS	ADGRL1 ADGRL2 ADGRL3	1.32e-04	37	50	3	IPR000203
Domain	G_PROTEIN_RECEP_F2_1	ADGRL1 ADGRL2 ADGRL3	1.66e-04	40	50	3	PS00649
Domain	G_PROTEIN_RECEP_F2_3	ADGRL1 ADGRL2 ADGRL3	1.66e-04	40	50	3	PS50227
Domain	GPCR_2_extracellular_dom	ADGRL1 ADGRL2 ADGRL3	1.66e-04	40	50	3	IPR001879
Domain	G_PROTEIN_RECEP_F2_2	ADGRL1 ADGRL2 ADGRL3	3.24e-04	50	50	3	PS00650
Domain	7tm_2	ADGRL1 ADGRL2 ADGRL3	3.24e-04	50	50	3	PF00002
Domain	ABC_A	ABCA5 ABCA8	4.56e-04	12	50	2	IPR026082
Domain	GPCR_2-like	ADGRL1 ADGRL2 ADGRL3	5.55e-04	60	50	3	IPR017981
Domain	GPCR_2_secretin-like	ADGRL1 ADGRL2 ADGRL3	5.55e-04	60	50	3	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	ADGRL1 ADGRL2 ADGRL3	5.82e-04	61	50	3	PS50261
Domain	TIR	TLR1 TLR6	1.43e-03	21	50	2	SM00255
Domain	TIR	TLR1 TLR6	1.57e-03	22	50	2	PF01582
Domain	-	TLR1 TLR6	1.71e-03	23	50	2	3.40.50.10140
Domain	TIR	TLR1 TLR6	1.87e-03	24	50	2	PS50104
Domain	TIR_dom	TLR1 TLR6	2.03e-03	25	50	2	IPR000157
Domain	LRRCT	TLR1 TLR6	3.31e-03	32	50	2	PF01463
Domain	ABC_TRANSPORTER_2	ABCA5 ABCA8	7.32e-03	48	50	2	PS50893
Domain	ABC_tran	ABCA5 ABCA8	7.32e-03	48	50	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCA5 ABCA8	7.62e-03	49	50	2	PS00211
Domain	ABC_transporter-like	ABCA5 ABCA8	7.93e-03	50	50	2	IPR003439
Pathway	WP_GPCRS_CLASS_B_SECRETINLIKE	ADGRL1 ADGRL2 ADGRL3	4.43e-05	24	41	3	MM15992
Pathway	WP_GPCRS_CLASS_B_SECRETINLIKE	ADGRL1 ADGRL2 ADGRL3	4.43e-05	24	41	3	M39643
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION	G6PC3 PYGM	2.93e-04	9	41	2	M47621
Pubmed	A family of heptahelical receptors with adhesion-like domains: a marriage between two super families.	ADGRL1 ADGRL2 ADGRL3	3.74e-09	3	55	3	10994649
Pubmed	The multiple actions of black widow spider toxins and their selective use in neurosecretion studies.	ADGRL1 ADGRL2 ADGRL3	3.74e-09	3	55	3	15066411
Pubmed	alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.	ADGRL1 ADGRL2 ADGRL3	3.74e-09	3	55	3	11520923
Pubmed	The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.	ADGRL1 ADGRL2 ADGRL3	7.46e-08	6	55	3	10964907
Pubmed	Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.	ADGRL1 ADGRL2 ADGRL3	4.46e-07	10	55	3	38713721
Pubmed	Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.	TLR1 TLR6	2.46e-06	2	55	2	22315281
Pubmed	Role of TLR1 and TLR6 in the host defense against disseminated candidiasis.	TLR1 TLR6	2.46e-06	2	55	2	18036178
Pubmed	Latrophilin receptors: novel bronchodilator targets in asthma.	ADGRL1 ADGRL3	2.46e-06	2	55	2	27325752
Pubmed	The association of genetic variants in toll-like receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy.	TLR1 TLR6	2.46e-06	2	55	2	24445834
Pubmed	The Roles of TLR Gene Polymorphisms in Atherosclerosis: A Systematic Review and Meta-Analysis of 35,317 Subjects.	TLR1 TLR6	2.46e-06	2	55	2	28474755
Pubmed	[DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS].	TLR1 TLR6	2.46e-06	2	55	2	26470427
Pubmed	Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.	TLR1 TLR6	2.46e-06	2	55	2	21852947
Pubmed	Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).	TLR1 TLR6	2.46e-06	2	55	2	24984237
Pubmed	Latrophilin GPCR signaling mediates synapse formation.	ADGRL2 ADGRL3	2.46e-06	2	55	2	33646123
Pubmed	A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.	TLR1 TLR6	2.46e-06	2	55	2	22778390
Pubmed	Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.	TLR1 TLR6	2.46e-06	2	55	2	11123271
Pubmed	SNPs in the exons of Toll-like receptors are associated with susceptibility to type 1 diabetes in Chinese population.	TLR1 TLR6	2.46e-06	2	55	2	25261617
Pubmed	Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins.	ADGRL2 ADGRL3	2.46e-06	2	55	2	30792275
Pubmed	Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazil.	TLR1 TLR6	2.46e-06	2	55	2	29175392
Pubmed	Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.	TLR1 TLR6	7.36e-06	3	55	2	19931471
Pubmed	Divergent roles of amino acid residues inside and outside the BB loop affect human Toll-like receptor (TLR)2/2, TLR2/1 and TLR2/6 responsiveness.	TLR1 TLR6	7.36e-06	3	55	2	23626692
Pubmed	Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk.	TLR1 TLR6	7.36e-06	3	55	2	15812078
Pubmed	Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.	TLR1 TLR6	7.36e-06	3	55	2	16081826
Pubmed	Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response.	TLR1 TLR6	7.36e-06	3	55	2	28123183
Pubmed	Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.	TLR1 TLR6	7.36e-06	3	55	2	18752252
Pubmed	Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists.	TLR1 TLR6	7.36e-06	3	55	2	22822027
Pubmed	Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.	TLR1 TLR6	7.36e-06	3	55	2	25028161
Pubmed	Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs.	TLR1 TLR6	7.36e-06	3	55	2	15731092
Pubmed	Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors.	TLR1 TLR6	7.36e-06	3	55	2	25246533
Pubmed	TLR1, TLR2, and TLR6 gene polymorphisms are associated with increased susceptibility to complicated skin and skin structure infections.	TLR1 TLR6	7.36e-06	3	55	2	24511099
Pubmed	The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.	TLR1 TLR6	7.36e-06	3	55	2	11095740
Pubmed	Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.	TLR1 TLR6	7.36e-06	3	55	2	18091991
Pubmed	TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation.	TLR1 TLR6	7.36e-06	3	55	2	16461792
Pubmed	Toll-like receptor 2 subfamily gene polymorphisms are associated with Bacillus Calmette-Guérin osteitis following newborn vaccination.	TLR1 TLR6	7.36e-06	3	55	2	25605403
Pubmed	Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.	TLR1 TLR6	7.36e-06	3	55	2	14966134
Pubmed	Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer.	TLR1 TLR6	7.36e-06	3	55	2	17932345
Pubmed	Toll-like receptor 2 subfamily genotypes are not associated with severity of bronchiolitis or postbronchiolitis wheezing in infants.	TLR1 TLR6	7.36e-06	3	55	2	24112285
Pubmed	IFNs activate toll-like receptor gene expression in viral infections.	TLR1 TLR6	7.36e-06	3	55	2	11607792
Pubmed	Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses.	TLR1 TLR6	7.36e-06	3	55	2	23151486
Pubmed	[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan].	TLR1 TLR6	7.36e-06	3	55	2	25850295
Pubmed	Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.	TLR1 TLR6	7.36e-06	3	55	2	12077222
Pubmed	Ureaplasma parvum lipoproteins, including MB antigen, activate NF-{kappa}B through TLR1, TLR2 and TLR6.	TLR1 TLR6	7.36e-06	3	55	2	18451040
Pubmed	TLR1- and TLR6-independent recognition of bacterial lipopeptides.	TLR1 TLR6	7.36e-06	3	55	2	16455646
Pubmed	Toll-like receptor polymorphisms are associated with increased neurosyphilis risk.	TLR1 TLR6	7.36e-06	3	55	2	24922103
Pubmed	Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells.	TLR1 TLR6	7.36e-06	3	55	2	24683188
Pubmed	A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6.	TLR1 TLR6	7.36e-06	3	55	2	16177110
Pubmed	Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins.	TLR1 TLR6	7.36e-06	3	55	2	17595379
Pubmed	Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis.	TLR1 TLR6	7.36e-06	3	55	2	22150367
Pubmed	Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.	TLR1 TLR6	7.36e-06	3	55	2	18056480
Pubmed	Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.	TLR1 TLR6	7.36e-06	3	55	2	16374251
Pubmed	TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes.	TLR1 TLR6	7.36e-06	3	55	2	21998742
Pubmed	Soluble Toll-like receptor 1 family members in the amniotic fluid of women with preterm prelabor rupture of the membranes.	TLR1 TLR6	7.36e-06	3	55	2	22280448
Pubmed	Toll-like receptor 1, 2 and 6 polymorphisms: no association with 11 serum cytokine concentrations.	TLR1 TLR6	7.36e-06	3	55	2	30028533
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	ADGRL1 ADGRL2 ADGRL3	1.33e-05	29	55	3	15203201
Pubmed	Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.	TLR1 TLR6	1.47e-05	4	55	2	23255565
Pubmed	Toll-like receptor heterodimer variants protect from childhood asthma.	TLR1 TLR6	1.47e-05	4	55	2	18547625
Pubmed	TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation.	TLR1 TLR6	1.47e-05	4	55	2	22198949
Pubmed	Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population.	TLR1 TLR6	1.47e-05	4	55	2	20815312
Pubmed	Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.	TLR1 TLR6	1.47e-05	4	55	2	20348427
Pubmed	Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver.	ABCA5 ABCA8	1.47e-05	4	55	2	16445568
Pubmed	A recombinant lipoprotein containing an unsaturated fatty acid activates NF-kappaB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide.	TLR1 TLR6	1.47e-05	4	55	2	20478617
Pubmed	Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum.	ADGRL2 ADGRL3	1.47e-05	4	55	2	32202499
Pubmed	Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes.	TLR1 TLR6	1.47e-05	4	55	2	24860120
Pubmed	Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.	TLR1 TLR6	1.47e-05	4	55	2	11739528
Pubmed	Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.	TLR1 TLR6	1.47e-05	4	55	2	11081518
Pubmed	Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS.	TLR1 TLR6	1.47e-05	4	55	2	16622218
Pubmed	Association of Toll-like receptor polymorphisms with HIV status in North Americans.	TLR1 TLR6	1.47e-05	4	55	2	25253287
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	ADGRL1 ADGRL2 ADGRL3	1.97e-05	33	55	3	25713288
Pubmed	Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.	TLR1 TLR6	2.45e-05	5	55	2	24014382
Pubmed	Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.	TLR1 TLR6	2.45e-05	5	55	2	22703024
Pubmed	Association of MBL2, TLR1, TLR2 and TLR6 Polymorphisms With Production of IFN-γ and IL-12 in BCG Osteitis Survivors R1.	TLR1 TLR6	2.45e-05	5	55	2	27755461
Pubmed	TLR-dependent control of Francisella tularensis infection and host inflammatory responses.	TLR1 TLR6	2.45e-05	5	55	2	19936231
Pubmed	Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses.	TLR1 TLR6	2.45e-05	5	55	2	15294986
Pubmed	Association between toll-like receptors/CD14 gene polymorphisms and inflammatory bowel disease in Korean population.	TLR1 TLR6	2.45e-05	5	55	2	22219617
Pubmed	Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans.	TLR1 TLR6	2.45e-05	5	55	2	19771452
Pubmed	TLR6: A novel member of an expanding toll-like receptor family.	TLR1 TLR6	2.45e-05	5	55	2	10231569
Pubmed	Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.	TLR1 TLR6	2.45e-05	5	55	2	16880211
Pubmed	Abnormal high-density lipoprotein induces endothelial dysfunction via activation of Toll-like receptor-2.	TLR1 TLR6	2.45e-05	5	55	2	23477738
Pubmed	Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk.	TLR1 TLR6	2.45e-05	5	55	2	16537705
Pubmed	A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma.	TLR1 TLR6	2.45e-05	5	55	2	19029192
Pubmed	Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes.	ABCA5 ABCA8	2.45e-05	5	55	2	12532264
Pubmed	NF-κB is activated from endosomal compartments in antiphospholipid antibodies-treated human monocytes.	TLR1 TLR6	2.45e-05	5	55	2	24612386
Pubmed	Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to Porphyromonas gingivalis.	TLR1 TLR6	2.45e-05	5	55	2	23077245
Pubmed	TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.	TLR1 TLR6	2.45e-05	5	55	2	19362712
Pubmed	Respiratory syncytial virus activates innate immunity through Toll-like receptor 2.	TLR1 TLR6	2.45e-05	5	55	2	19019963
Pubmed	TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS.	TLR1 TLR6	3.67e-05	6	55	2	32652111
Pubmed	Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.	TLR1 TLR6	3.67e-05	6	55	2	17004992
Pubmed	Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in experimental autoimmune encephalomyelitis.	TLR1 TLR6	3.67e-05	6	55	2	21685327
Pubmed	Structural and functional understanding of the toll-like receptors.	TLR1 TLR6	3.67e-05	6	55	2	33576548
Pubmed	Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing.	ERCC6 UBTF	3.67e-05	6	55	2	23562818
Pubmed	Genetic differences between five European populations.	TLR1 TLR6	3.67e-05	6	55	2	20616560
Pubmed	Symbionts exploit complex signaling to educate the immune system.	TLR1 TLR6	3.67e-05	6	55	2	31811024
Pubmed	Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses.	TLR1 TLR6	3.67e-05	6	55	2	18195069
Pubmed	Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.	TLR1 TLR6	3.67e-05	6	55	2	10426995
Pubmed	Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India.	TLR1 TLR6	3.67e-05	6	55	2	20797905
Pubmed	Isolated Toll-like receptor transmembrane domains are capable of oligomerization.	TLR1 TLR6	5.13e-05	7	55	2	23155421
Pubmed	Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases.	TLR1 TLR6	5.13e-05	7	55	2	18776592
Pubmed	Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease.	TLR1 TLR6	5.13e-05	7	55	2	17595233
Pubmed	Identification of genetic loci associated with Helicobacter pylori serologic status.	TLR1 TLR6	5.13e-05	7	55	2	23652523
Pubmed	The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation.	ERCC6 UBTF	5.13e-05	7	55	2	23667505
Cytoband	17q23.2	INTS2 PPM1D	7.27e-04	33	55	2	17q23.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	NPIPB7 GTF3C1 NPIPB6	1.17e-03	172	55	3	chr16p12
Cytoband	4p14	TLR1 TLR6	1.18e-03	42	55	2	4p14
Cytoband	16p11.2	NPIPB8 NPIPB7 NPIPB6	1.59e-03	191	55	3	16p11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr4p14	TLR1 TLR6	2.96e-03	67	55	2	chr4p14
Cytoband	17q21.31	G6PC3 UBTF	4.40e-03	82	55	2	17q21.31
GeneFamily	Adhesion G protein-coupled receptors, subfamily L	ADGRL1 ADGRL2 ADGRL3	2.21e-08	4	33	3	918
GeneFamily	CD molecules\|Toll like receptors	TLR1 TLR6	1.44e-04	10	33	2	948
GeneFamily	ATP binding cassette subfamily A	ABCA5 ABCA8	2.90e-04	14	33	2	805
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	CCDC88C GTF3C1 SYNE2 ADGRL1 B3GAT1	4.24e-06	195	55	5	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CCDC88C GTF3C1 SYNE2 ADGRL1 B3GAT1	4.35e-06	196	55	5	6beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC88C GTF3C1 SYNE2 ADGRL1 B3GAT1	4.35e-06	196	55	5	c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CCDC88C GTF3C1 SYNE2 ADGRL1 B3GAT1	4.35e-06	196	55	5	418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC88C GTF3C1 SYNE2 ADGRL1 B3GAT1	4.35e-06	196	55	5	581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T\|COVID-19_Severe / Disease, condition lineage and cell class	CCDC88C GTF3C1 INPP4A SYNE2 B3GAT1	4.79e-06	200	55	5	f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
Drug	tungstate	G6PC3 MTHFD1L UBTF PYGM PNP	3.91e-06	108	50	5	CID000001152
Drug	glycerylcysteine	TLR1 TLR6	2.83e-05	4	50	2	CID000152469
Drug	black widow spider venom	ADGRL1 ADGRL2	2.83e-05	4	50	2	ctd:C038599
Drug	5-deoxyribose-1-phosphate	PYGM PNP	2.83e-05	4	50	2	CID000135786
Drug	alpha-latrotoxin	ADGRL1 ADGRL2	2.83e-05	4	50	2	ctd:C020763
Drug	4-nitrobiphenyl	UBTF MAP3K11 RRP1	3.14e-05	28	50	3	CID000007114
Disease	1-stearoylglycerol 1-monostearin measurement	SYNE2 KIAA1549	2.81e-06	2	50	2	EFO_0021111
Disease	attention deficit hyperactivity disorder (implicated_via_orthology)	ADGRL1 ADGRL2 ADGRL3	1.46e-05	28	50	3	DOID:1094 (implicated_via_orthology)
Disease	aspergillosis (is_implicated_in)	TLR1 TLR6	7.83e-05	8	50	2	DOID:13564 (is_implicated_in)
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR1 TLR6	3.77e-04	17	50	2	DOID:8677 (biomarker_via_orthology)
Disease	tuberculosis (is_implicated_in)	TLR1 TLR6	1.03e-03	28	50	2	DOID:399 (is_implicated_in)
Disease	putamen volume	GRB10 DSCAML1	1.27e-03	31	50	2	EFO_0006932
Disease	neuroimaging measurement, brain volume measurement	CCDC88C NPIPB8 GRB10 DSCAML1	1.40e-03	286	50	4	EFO_0004346, EFO_0006930

Protein segments in the cluster

Peptide	Gene	Start	Entry
PNWEVMRSTRRVREL	TBC1D12	466	O60347
MSTAIREVGVWRQTR	ABCA5	1	Q8WWZ7
GTMQRNLALRWLRET	B3GAT1	166	Q9P2W7
TRRRTWSRDEVMGDN	CEP170	1401	Q5SW79
VPEKTWRAQRMSQRR	FAM74A1	31	Q5RGS3
WRAQRMSQRRRGESS	FAM74A1	36	Q5RGS3
QSRIRRMWNDTVRKQ	ADGRL1	1146	O94910
NRQSVVMVEEWRRPA	CALHM3	71	Q86XJ0
WRIGTDGRTVRRTMN	GPR19	251	Q15760
MPDSWRGLVTRTVRQ	ABHD16A	391	O95870
TGSQSRIRRMWNDTV	ADGRL3	1146	Q9HAR2
RIRRMWNDTVRKQSE	ADGRL3	1151	Q9HAR2
GTQSRIRRMWNDTVR	ADGRL2	1131	O95490
IRRMWNDTVRKQSES	ADGRL2	1136	O95490
RIQNMVSSGRRWLRE	MTHFD1L	326	Q6UB35
MARWTGRNSRSSLQV	INPP4A	506	Q96PE3
RVVERWQKSMTNRTR	SERPIND1	376	P05546
RRRMWRRATVAAGNS	KIAA1549	1206	Q9HCM3
VSVPRRRMFWEQRTD	ERCC6	661	P0DP91
IMRVLNVDARRRWST	P2RY11	266	Q96G91
GNSAREAQVWEMLRR	MAGEF1	181	Q9HAY2
RSRNDQVVTDLRLWM	ASL	111	P04424
SQVATRARSRWVRVM	G6PC3	131	Q9BUM1
LNRAMWSLRERSQVS	CCDC88C	566	Q9P219
QRKRETSSSVLWQMR	INTS2	326	Q9H0H0
DGSMDVQQRAWRSNR	NPIPB8	116	E9PQR5
TWQRNAMRRRQKTTR	DCAF5	581	Q96JK2
MWTRQFKRTGETRRI	MEGF8	2011	Q7Z7M0
ALRTRAWRAGTVRAM	KDM3B	41	Q7LBC6
QLARSSWVGRMLRSQ	LMNTD2	166	Q8IXW0
GRTRGWVQTLARMSR	C6orf223	101	Q8N319
WVQTLARMSRRTRGP	C6orf223	106	Q8N319
GRWRQRMLRADNTSA	PPM1D	356	O15297
MDVQQRAWRSNRSRQ	NPIPB7	101	O75200
MSRRVRTSELWKRNG	POM121B	1	A6NF01
SSRRQRARNMGFWRS	GASK1A	66	Q9UFP1
RRSNIMWLDRDGTVQ	IGSF3	456	O75054
REVKARSMNLRWTQR	DSCAML1	896	Q8TD84
RSMNLRWTQRFDGNS	DSCAML1	901	Q8TD84
RWRTLRSIVERMANV	HUS1B	161	Q8NHY5
RESLMNQSRWNSGLR	COMMD1	106	Q8N668
AWRKRSTRMNILGSQ	GRB10	461	Q13322
DGSMDVQQRAWRSNR	NPIPB6	116	E9PJ23
RQRALSTWKQMGEQR	PNP	171	P00491
RNRAVANTWTLMRKS	KIF28P	356	B7ZC32
AQNGRRRSRMDEATW	MAP3K11	576	Q16584
MDVQQRAWRSNRSRQ	NPIPB9	116	F8W1W9
FQSRMTGSRNWRATR	OGFR	56	Q9NZT2
VPEKTWRAQRMSQRR	FAM74A4	31	Q5TZK3
WRAQRMSQRRRGESS	FAM74A4	36	Q5TZK3
MNRQWIRATATALER	SYNE2	5571	Q8WXH0
QTMNREWTGIDRLRL	RRP1	101	P56182
RMVCQWTQTRRRARN	TLR1	611	Q15399
MWQAIRATFRNTERG	ABCA8	1456	O94911
MEQRNSRWNTVLRAV	TRPA1	1096	O75762
REWTRMVIRNIATSG	PYGM	796	P11217
MTRKIFTNTRERWRQ	TAL2	1	Q16559
RMVCQWTQTRRRARN	TLR6	616	Q9Y2C9
RNEQLWIMTTATRRQ	ZNF226	61	Q9NYT6
RMVEIGSRWQRISQS	UBTF	596	P17480
DQSALQRMTRLRVTW	GTF3C1	1251	Q12789
RSSEAEMQWRLQVNR	NECAB3	216	Q96P71