Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF629 SOX18 ZNF668 ELK1 RELB ZFP42 KMT2D GLIS2	2.72e-06	560	33	8	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF629 SOX18 ZNF668 ELK1 RELB ZFP42 KMT2D GLIS2	2.95e-06	566	33	8	GO:0001216
GeneOntologyMolecularFunction	molecular adaptor activity	MED14 SHARPIN ELK1 KMT2D ABI3 SCRIB FLYWCH1 AKAP1 RUFY1 TLE1	4.41e-05	1356	33	10	GO:0060090
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	MED14 SHARPIN ELK1 KMT2D ABI3 SCRIB FLYWCH1 RUFY1 TLE1	7.92e-05	1160	33	9	GO:0030674
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF629 SOX18 ZNF668 ELK1 RELB ZFP42 SNAPC4 GLIS2 ZNF316	1.35e-04	1244	33	9	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF629 SOX18 ZNF668 ELK1 RELB ZFP42 SNAPC4 GLIS2 ZNF316	1.59e-04	1271	33	9	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF629 SOX18 ZNF668 ELK1 RELB ZFP42 KMT2D GLIS2 ZNF316	3.51e-04	1412	33	9	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF629 SOX18 ZNF668 ELK1 RELB ZFP42 SNAPC4 GLIS2 ZNF316	4.48e-04	1459	33	9	GO:0000977
GeneOntologyMolecularFunction	transcription coregulator activity	MED14 ELK1 KMT2D FLYWCH1 TLE1	2.14e-03	562	33	5	GO:0003712
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	MED14 ELK1	4.56e-03	61	33	2	GO:0030374
GeneOntologyBiologicalProcess	auditory receptor cell stereocilium organization	SCRIB STRC STRCP1	9.46e-06	26	33	3	GO:0060088
GeneOntologyBiologicalProcess	auditory receptor cell morphogenesis	SCRIB STRC STRCP1	1.63e-05	31	33	3	GO:0002093
GeneOntologyBiologicalProcess	auditory receptor cell development	SCRIB STRC STRCP1	3.54e-05	40	33	3	GO:0060117
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	ZNF629 MED14 SOX18 ZNF668 ELK1 RELB ZFP42 KMT2D CDK12 GLIS2	4.13e-05	1390	33	10	GO:0045944
GeneOntologyBiologicalProcess	epidermis development	SHARPIN SOX18 SCRIB STRC HPSE STRCP1	8.01e-05	461	33	6	GO:0008544
GeneOntologyBiologicalProcess	inner ear receptor cell stereocilium organization	SCRIB STRC STRCP1	8.28e-05	53	33	3	GO:0060122
GeneOntologyBiologicalProcess	inner ear auditory receptor cell differentiation	SCRIB STRC STRCP1	1.67e-04	67	33	3	GO:0042491
GeneOntologyBiologicalProcess	inner ear receptor cell development	SCRIB STRC STRCP1	2.15e-04	73	33	3	GO:0060119
GeneOntologyBiologicalProcess	hair cell differentiation	SCRIB STRC STRCP1	2.62e-04	78	33	3	GO:0035315
GeneOntologyBiologicalProcess	inner ear receptor cell differentiation	SCRIB STRC STRCP1	4.82e-04	96	33	3	GO:0060113
GeneOntologyBiologicalProcess	mechanoreceptor differentiation	SCRIB STRC STRCP1	6.09e-04	104	33	3	GO:0042490
GeneOntologyBiologicalProcess	detection of mechanical stimulus involved in sensory perception of sound	STRC STRCP1	6.15e-04	23	33	2	GO:0050910
GeneOntologyCellularComponent	transcription regulator complex	MED14 SOX18 RELB ZFP42 SNAPC4 FLYWCH1 TLE1 GLIS2	3.08e-06	596	33	8	GO:0005667
GeneOntologyCellularComponent	kinocilium	STRC STRCP1	2.17e-04	14	33	2	GO:0060091
GeneOntologyCellularComponent	9+2 non-motile cilium	STRC STRCP1	2.17e-04	14	33	2	GO:0097732
GeneOntologyCellularComponent	stereocilium tip	STRC STRCP1	5.47e-04	22	33	2	GO:0032426
GeneOntologyCellularComponent	nuclear protein-containing complex	MED14 RELB ZFP42 KMT2D POM121C CTC1 CDK12 TLE1	1.09e-03	1377	33	8	GO:0140513
Domain	-	ZNF629 ZNF668 ZFP42 GLIS2 ZFP91 ZNF316	7.64e-04	679	31	6	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF629 ZNF668 ZFP42 GLIS2 ZFP91 ZNF316	8.56e-04	694	31	6	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF629 ZNF668 ZFP42 GLIS2 ZFP91 ZNF316	1.51e-03	775	31	6	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF629 ZNF668 ZFP42 GLIS2 ZFP91 ZNF316	1.53e-03	777	31	6	PS00028
Domain	Znf_C2H2-like	ZNF629 ZNF668 ZFP42 GLIS2 ZFP91 ZNF316	1.74e-03	796	31	6	IPR015880
Domain	Znf_C2H2	ZNF629 ZNF668 ZFP42 GLIS2 ZFP91 ZNF316	1.84e-03	805	31	6	IPR007087
Domain	ZnF_C2H2	ZNF629 ZNF668 ZFP42 GLIS2 ZFP91 ZNF316	1.87e-03	808	31	6	SM00355
Domain	HMG_box	SOX18 KMT2D	3.49e-03	53	31	2	PF00505
Domain	HMG	SOX18 KMT2D	3.62e-03	54	31	2	SM00398
Domain	-	SOX18 KMT2D	3.75e-03	55	31	2	1.10.30.10
Domain	HMG_box_dom	SOX18 KMT2D	5.20e-03	65	31	2	IPR009071
Domain	zf-C2H2	ZNF629 ZNF668 GLIS2 ZFP91 ZNF316	5.29e-03	693	31	5	PF00096
Domain	Prefoldin	RUFY1 TLE1	6.34e-03	72	31	2	IPR009053
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MED14 RELB KMT2D SNAPC4 POM121C ARVCF CTC1 CDK12 WNK2 ZNF316	4.79e-08	1105	33	10	35748872
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	8.73e-07	2	33	2	34910522
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	8.73e-07	2	33	2	11687802
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	2.62e-06	3	33	2	30801007
Pubmed	HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.	SOX18 RELB TLE1	3.79e-06	32	33	3	11748221
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	5.23e-06	4	33	2	18849963
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MED14 KMT2D SCRIB SNAPC4 AKAP1 CDK12 ZFP91	6.79e-06	774	33	7	15302935
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	8.72e-06	5	33	2	24920589
Pubmed	Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.	RELB KMT2D	1.83e-05	7	33	2	19219072
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	2.44e-05	8	33	2	21165971
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	4.78e-05	11	33	2	31776257
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	4.78e-05	11	33	2	31448880
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	KMT2D CDK12 TLE1	6.79e-05	83	33	3	28794006
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	ZNF629 MED14 ZNF668 AKAP1 CDK12 BCKDK	7.09e-05	759	33	6	35915203
Pubmed	UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.	AKAP1 RUFY1 TLE1 LRRC47	1.17e-04	267	33	4	33417871
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	1.18e-04	17	33	2	20856818
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	KMT2D SCRIB LRRC47	1.40e-04	106	33	3	31024071
Pubmed	SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.	ELK1 SCRIB	1.48e-04	19	33	2	21965329
Pubmed	Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering.	TLE1 WNK2	1.48e-04	19	33	2	9070936
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	MED14 KMT2D SCRIB RUFY1 CDK12	1.59e-04	549	33	5	38280479
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	ZNF629 MED14 SCRIB ZFP91 LRRC47	3.34e-04	645	33	5	25281560
Pubmed	Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2.	ARVCF SCARF2	4.53e-04	33	33	2	10704284
Pubmed	A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.	STRC STRCP1	6.01e-04	38	33	2	38346162
Pubmed	Association of gene polymorphisms with chronic kidney disease in Japanese individuals.	ARVCF WNK2	6.33e-04	39	33	2	19724895
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KMT2D AKAP1 RUFY1 TLE1	6.39e-04	418	33	4	34709266
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ZNF629 TLE1 WNK2 LRRC47	8.48e-04	451	33	4	36168627
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	MED14 FLYWCH1 CTC1 ZNF316	8.62e-04	453	33	4	29656893
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	KMT2D POM121C CDK12 TLE1	8.90e-04	457	33	4	32344865
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	AKAP1 CTC1 WNK2 BCKDK	9.27e-04	462	33	4	31138677
Cytoband	15q15.3	STRC STRCP1	1.49e-04	25	33	2	15q15.3
Cytoband	16p11.2	ZNF629 ZNF668 BCKDK	3.53e-04	191	33	3	16p11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16p11	ZNF629 ZNF668 BCKDK	1.05e-03	278	33	3	chr16p11
Cytoband	22q11.21	ARVCF SCARF2	2.91e-03	111	33	2	22q11.21
Cytoband	8q24.3	SHARPIN SCRIB	3.02e-03	113	33	2	8q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	STRC STRCP1	5.04e-03	147	33	2	chr15q15
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF629 ZNF668 ZFP42 GLIS2 ZFP91 ZNF316	2.17e-04	718	23	6	28
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	1.14e-06	2	32	2	DOID:0110471 (implicated_via_orthology)
Disease	atopic dermatitis (implicated_via_orthology)	SHARPIN RELB	6.23e-05	11	32	2	DOID:3310 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	MED14 ZNF668 KMT2D HPSE RUFY1 SCARF2	9.22e-04	1074	32	6	C0006142
Disease	visceral adipose tissue measurement	ZNF668 ZFP42 POM121C TLE1	1.75e-03	481	32	4	EFO_0004765
Disease	Alzheimer disease, gastroesophageal reflux disease	ZNF629 RELB ABI3	1.91e-03	228	32	3	EFO_0003948, MONDO_0004975
Disease	wellbeing measurement, alcohol consumption measurement	RELB CDK12	2.93e-03	74	32	2	EFO_0007869, EFO_0007878
Disease	central corneal thickness	ARVCF BCKDK GLIS2	4.51e-03	309	32	3	EFO_0005213
Disease	Alzheimer disease, family history of Alzheimer’s disease	RELB BCKDK	7.39e-03	119	32	2	EFO_0009268, MONDO_0004975
Disease	puberty onset measurement	AKAP1 GLIS2	8.13e-03	125	32	2	EFO_0005677

Protein segments in the cluster

Peptide	Gene	Start	Entry
DAGLPLPGLPAEGSP	AKAP1	416	Q92667
LTDLPLPPELPGGDL	CDK12	666	Q9NYV4
LPLSPSLLGGPGPER	ELK1	321	P19419
VGPDGLPLLDGGPPL	ARVCF	141	O00192
LPLLDGGPPLGPFAD	ARVCF	146	O00192
EDPHLPPSLGLLPGA	CTC1	951	Q2NKJ3
SDLLSPEGPGPGPDL	GTPBP3	376	Q969Y2
PGGGLPLRPLLGPAL	BCKDK	11	O14874
VSLPGLEPPGGPDLL	RELB	471	Q01201
DLPPPPPLDGDELGL	ABI3	276	Q9P2A4
PSLALPEGLGEPQGP	FLYWCH1	191	Q4VC44
ALGPGLSPELGPLPA	LRRC47	86	Q8N1G4
LLLSGAPGLPLPPGA	LIX1L	56	Q8IVB5
GLPGLPLPLAPGPLD	GLIS2	366	Q9BZE0
GGLGPLSLPPDLPDL	OSTM1	66	Q86WC4
LLLGPLGPLSPGALP	HPSE	16	Q9Y251
LLPSPTPGLVPGLAG	MED14	1186	O60244
LPPLGLSQSGPPGLL	POM121C	611	A8CG34
LEPELEPGPGPGSAL	RUFY1	16	Q96T51
GELGRLFPPSLGLPP	SHARPIN	321	Q9H0F6
GGGLRLPLLPPESPG	SCRIB	841	Q14160
EGLLGPLLPSLPPLG	STRC	571	Q7RTU9
GLRPGLGKPPAIDPL	TLE1	336	Q04724
GLGDPPAGLLGLPPE	ZNF668	451	Q96K58
GEGLALSPLLPGVPP	nan	36	Q6ZSN1
GAGGPPSPLLPSLLL	SCARF2	16	Q96GP6
KLPPGGIPGIDLSDP	ZFP42	151	Q96MM3
PLPAPLGGPLSLVEG	ZNF316	631	A6NFI3
GTPGPAGLLATLLPP	SNAPC4	1101	Q5SXM2
EGLLGPLLPSLPPLG	STRCP1	571	A6NGW2
PPLGAEFDGLGLPTP	SOX18	201	P35713
PSDGQGLPLLPEPLG	ZFP91	486	Q96JP5
PLAGIDGLPPALPDL	WNK2	806	Q9Y3S1
LLGLGDPSLLTPPPG	ZNF629	551	Q9UEG4
PGEPSLSPLLGEPAL	KMT2D	886	O14686