Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	HMGI/Y_DNA-bd_CS	PLEKHA4 BAZ2A	5.49e-04	31	21	2	IPR000637
Domain	SH3_2	RIMBP2 MIA3	4.16e-03	86	21	2	IPR011511
Domain	SH3_2	RIMBP2 MIA3	4.16e-03	86	21	2	PF07653
Domain	Znf_FYVE_PHD	BAZ2A ZFYVE21	1.17e-02	147	21	2	IPR011011
Domain	-	UBOX5 BAZ2A ZFYVE21	1.33e-02	449	21	3	3.30.40.10
Domain	Znf_RING/FYVE/PHD	UBOX5 BAZ2A ZFYVE21	1.41e-02	459	21	3	IPR013083
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	OGDHL TPGS1 PRPF40A RIMBP2 DLGAP3 HAX1	1.53e-04	1431	21	6	37142655
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	SLC25A46 BAZ2A OGDHL TPGS1 MIA3 HAX1	1.95e-04	1496	21	6	32877691
Cytoband	20p13	UBOX5 SIGLEC1	9.99e-04	102	21	2	20p13
Cytoband	Ensembl 112 genes in cytogenetic band chr20p13	UBOX5 SIGLEC1	1.45e-03	123	21	2	chr20p13
Drug	deferoxamine mesylate salt; Up 200; 100uM; MCF7; HG-U133A	UBOX5 BAZ2A DLC1 TFR2	2.62e-05	192	21	4	485_UP
Drug	dexamethasone; Up 200; 1uM; MCF7; HG-U133A	BAZ2A MIA3 SIGLEC1 TFR2	2.90e-05	197	21	4	255_UP
Drug	Metoclopramide monohydrochloride [7232-21-5]; Down 200; 11.8uM; MCF7; HT_HG-U133A	UBOX5 DHRS12 DLC1 TBC1D2B	2.96e-05	198	21	4	4750_DN
Drug	benzamide riboside	TFR2 BAD	3.71e-04	31	21	2	CID000122749
Drug	Fenoterol hydrobromide [1944-12-3]; Up 200; 10.4uM; PC3; HT_HG-U133A	BAZ2A DNAH7 RIMBP2	6.01e-04	182	21	3	6331_UP
Drug	Methotrexate [59-05-2]; Up 200; 8.8uM; MCF7; HT_HG-U133A	OGDHL DLC1 TBC1D2B	6.50e-04	187	21	3	5419_UP
Drug	ICI182,780; Down 200; 1uM; MCF7; HT_HG-U133A	UBOX5 DHRS12 MIA3	6.81e-04	190	21	3	5926_DN
Drug	Fluocinonide [356-12-7]; Up 200; 8uM; PC3; HT_HG-U133A	DHRS12 TFR2 TBC1D2B	6.81e-04	190	21	3	4314_UP
Drug	Bepridil hydrochloride [74764-40-2]; Up 200; 10uM; PC3; HT_HG-U133A	OGDHL DNAH7 TEX13B	6.91e-04	191	21	3	4613_UP
Drug	Drofenine hydrochloride [548-66-3]; Up 200; 11.4uM; MCF7; HT_HG-U133A	UBOX5 BAZ2A TBC1D2B	6.91e-04	191	21	3	6776_UP
Drug	Simvastatin [79902-63-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A	UBOX5 BAZ2A DLC1	7.23e-04	194	21	3	4828_UP
Drug	Delcorine; Down 200; 8.4uM; PC3; HT_HG-U133A	UBOX5 DLC1 TBC1D2B	7.23e-04	194	21	3	4275_DN
Drug	15d-PGJ2; Up 200; 10uM; PC3; HG-U133A	DLC1 TEX13B TBC1D2B	7.23e-04	194	21	3	446_UP
Drug	Levamisole hydrochloride [16595-80-5]; Up 200; 16.6uM; HL60; HG-U133A	BAZ2A TFR2 BAD	7.34e-04	195	21	3	1410_UP
Drug	Guanfacine hydrochloride [29110-48-3]; Up 200; 14.2uM; MCF7; HT_HG-U133A	BAZ2A RIMBP2 SIGLEC1	7.34e-04	195	21	3	5256_UP
Drug	PF-00539758-00 [351321-34-1]; Up 200; 10uM; PC3; HT_HG-U133A	DLC1 TFR2 TBC1D2B	7.34e-04	195	21	3	6379_UP
Drug	Aminopurine, 6-benzyl [1214-39-7]; Down 200; 17.8uM; MCF7; HT_HG-U133A	UBOX5 BAZ2A DHRS12	7.34e-04	195	21	3	2313_DN
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Up 200; 12.2uM; PC3; HT_HG-U133A	OGDHL SIGLEC1 TBC1D2B	7.34e-04	195	21	3	4016_UP
Drug	Glycopyrrolate [596-51-0]; Up 200; 10uM; MCF7; HT_HG-U133A	UBOX5 BAZ2A DHRS12	7.34e-04	195	21	3	3427_UP
Drug	Crotamiton [483-63-6]; Down 200; 19.6uM; HL60; HT_HG-U133A	UBOX5 DLC1 TFR2	7.34e-04	195	21	3	3050_DN
Drug	Amethopterin (R,S) [59-05-2]; Up 200; 8.8uM; MCF7; HT_HG-U133A	UBOX5 MIA3 DLC1	7.45e-04	196	21	3	5000_UP
Drug	Nystatine [1400-61-9]; Up 200; 4.4uM; MCF7; HT_HG-U133A	UBOX5 RIMBP2 DLC1	7.45e-04	196	21	3	4807_UP
Drug	Pargyline hydrochloride [306-07-0]; Up 200; 20.4uM; HL60; HG-U133A	DHRS12 TFR2 BAD	7.45e-04	196	21	3	1418_UP
Drug	Xamoterol hemifumarate [73210-73-8]; Up 200; 5uM; HL60; HT_HG-U133A	BAZ2A RIMBP2 SIGLEC1	7.45e-04	196	21	3	3064_UP
Drug	1,1-dimethylbiguanide hydrochloride; Down 200; 10uM; MCF7; HG-U133A	BAZ2A PRPF40A DLC1	7.45e-04	196	21	3	2_DN
Drug	6-mercaptopurine monohydrate; Up 200; 10uM; PC3; HG-U133A	BAZ2A MIA3 TBC1D2B	7.45e-04	196	21	3	667_UP
Drug	haloperidol; Down 200; 10uM; MCF7; HG-U133A	UBOX5 TFR2 TBC1D2B	7.45e-04	196	21	3	492_DN
Drug	Spiramycin [8025-81-8]; Down 200; 4.8uM; PC3; HT_HG-U133A	UBOX5 BAZ2A OGDHL	7.45e-04	196	21	3	3762_DN
Drug	Nifedipine [21829-25-4]; Up 200; 11.6uM; HL60; HT_HG-U133A	DHRS12 DLC1 TFR2	7.45e-04	196	21	3	1856_UP
Drug	Tenoxicam [59804-37-4]; Down 200; 11.8uM; MCF7; HT_HG-U133A	UBOX5 DHRS12 DLC1	7.45e-04	196	21	3	4182_DN
Drug	CP-944629 [668990-94-1]; Up 200; 10uM; PC3; HT_HG-U133A	BAZ2A DNAH7 DHRS12	7.45e-04	196	21	3	7502_UP
Drug	Trimethobenzamide hydrochloride [554-92-7]; Down 200; 9.4uM; PC3; HT_HG-U133A	BAZ2A DNAH7 DLC1	7.45e-04	196	21	3	4100_DN
Drug	2-propylpentanoic acid; Down 200; 50uM; PC3; HT_HG-U133A	UBOX5 BAZ2A DNAH7	7.45e-04	196	21	3	4446_DN
Drug	Epiandrosterone [481-29-8]; Down 200; 13.8uM; MCF7; HT_HG-U133A	MIA3 BAD TBC1D2B	7.45e-04	196	21	3	3306_DN
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; HL60; HT_HG-U133A	UBOX5 DLC1 TBC1D2B	7.45e-04	196	21	3	2553_DN
Drug	methyl 4-mercaptobutyrimidate	SIGLEC1 BAD	7.49e-04	44	21	2	CID000123925
Drug	Tiletamine hydrochloride; Up 200; 15.4uM; PC3; HT_HG-U133A	UBOX5 BAZ2A DNAH7	7.56e-04	197	21	3	7311_UP
Drug	aspirin, USP; Up 200; 100uM; MCF7; HT_HG-U133A	DNAH7 DHRS12 DLC1	7.56e-04	197	21	3	6964_UP
Drug	Piracetam [7491-74-9]; Up 200; 28.2uM; MCF7; HT_HG-U133A	DHRS12 TFR2 TEX13B	7.56e-04	197	21	3	5462_UP
Drug	Amiodarone hydrochloride [19774-82-4]; Up 200; 5.8uM; MCF7; HT_HG-U133A	UBOX5 RIMBP2 TFR2	7.56e-04	197	21	3	5618_UP
Drug	Esculin Hydrate [531-75-9]; Up 200; 11.8uM; PC3; HT_HG-U133A	BAZ2A DNAH7 ZFYVE21	7.56e-04	197	21	3	6310_UP
Drug	ICI 182,780; Up 200; 1uM; MCF7; HG-U133A	BAZ2A RIMBP2 TBC1D2B	7.56e-04	197	21	3	367_UP
Drug	Cephalexin monohydrate [23325-78-2]; Down 200; 11uM; MCF7; HT_HG-U133A	UBOX5 BAD TBC1D2B	7.56e-04	197	21	3	5250_DN
Drug	Meglumine [6284-40-8]; Down 200; 20.4uM; HL60; HT_HG-U133A	UBOX5 DHRS12 TFR2	7.56e-04	197	21	3	3068_DN
Drug	Norfloxacin [70458-96-7]; Up 200; 12.6uM; MCF7; HT_HG-U133A	BAZ2A DLC1 TFR2	7.56e-04	197	21	3	2253_UP
Drug	Cinchonine [118-10-5]; Up 200; 13.6uM; PC3; HT_HG-U133A	BAZ2A OGDHL TBC1D2B	7.56e-04	197	21	3	3988_UP
Drug	Sulindac [38194-50-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A	UBOX5 BAZ2A DLC1	7.56e-04	197	21	3	1693_UP
Drug	Haloperidol [52-86-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A	UBOX5 OGDHL DNAH7	7.56e-04	197	21	3	5638_UP
Drug	Lobelanidine hydrochloride [6112-86-3]; Down 200; 10.6uM; MCF7; HT_HG-U133A	UBOX5 BAZ2A DLC1	7.56e-04	197	21	3	5500_DN
Drug	Methylatropine nitrate [52-88-0]; Up 200; 11uM; MCF7; HT_HG-U133A	BAZ2A DHRS12 DLC1	7.68e-04	198	21	3	6495_UP
Drug	Tiletamine hydrochloride; Up 200; 15.4uM; MCF7; HT_HG-U133A	UBOX5 SIGLEC1 DLC1	7.68e-04	198	21	3	6013_UP
Drug	Doxazosin mesylate [77883-43-3]; Down 200; 7.4uM; HL60; HT_HG-U133A	UBOX5 TFR2 BAD	7.68e-04	198	21	3	3024_DN
Drug	Ifosfamide [3778-73-2]; Up 200; 15.4uM; PC3; HT_HG-U133A	OGDHL TFR2 TBC1D2B	7.68e-04	198	21	3	5805_UP
Drug	Atropine-N-oxide hydrochloride [4574-60-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	UBOX5 BAZ2A TBC1D2B	7.68e-04	198	21	3	6812_DN
Drug	Acebutolol hydrochloride [34381-68-5]; Up 200; 10.8uM; MCF7; HT_HG-U133A	BAZ2A DLC1 TBC1D2B	7.68e-04	198	21	3	1493_UP
Drug	Triflusal [322-79-2]; Up 200; 16.2uM; MCF7; HT_HG-U133A	BAZ2A DHRS12 TFR2	7.68e-04	198	21	3	2867_UP
Drug	Astemizole [68844-77-9]; Down 200; 8.8uM; MCF7; HT_HG-U133A	UBOX5 MIA3 TBC1D2B	7.68e-04	198	21	3	2211_DN
Drug	Thalidomide [50-35-1]; Up 200; 15.4uM; HL60; HG-U133A	UBOX5 BAZ2A DLC1	7.68e-04	198	21	3	1411_UP
Drug	Doxycycline hydrochloride [10592-13-9]; Up 200; 8.4uM; MCF7; HT_HG-U133A	BAZ2A DHRS12 TBC1D2B	7.68e-04	198	21	3	3479_UP
Drug	Methacycline hydrochloride [3963-95-9]; Up 200; 8.4uM; PC3; HT_HG-U133A	SIGLEC1 DLC1 TBC1D2B	7.68e-04	198	21	3	4062_UP
Drug	raloxifene hydrochloride; Up 200; 0.1uM; ssMCF7; HG-U133A	UBOX5 BAZ2A BAD	7.68e-04	198	21	3	376_UP
Drug	Iocetamic acid [16034-77-8]; Down 200; 6.6uM; MCF7; HT_HG-U133A	UBOX5 DHRS12 MIA3	7.68e-04	198	21	3	3361_DN
Drug	Oxytetracycline dihydrate [6153-64-6]; Up 200; 8uM; MCF7; HT_HG-U133A	RIMBP2 MIA3 SIGLEC1	7.68e-04	198	21	3	3170_UP
Drug	Minaprine dihydrochloride [25953-17-7]; Up 200; 10.8uM; PC3; HT_HG-U133A	BAZ2A DHRS12 RIMBP2	7.68e-04	198	21	3	4230_UP
Drug	Milrinone [78415-72-2]; Up 200; 19uM; MCF7; HT_HG-U133A	RIMBP2 SIGLEC1 DLC1	7.68e-04	198	21	3	7210_UP
Drug	Ondansetron Hydrochloride [103639-04-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A	UBOX5 DNAH7 DLC1	7.68e-04	198	21	3	6270_UP
Drug	Cholecalciferol [67-97-0]; Up 200; 10.4uM; MCF7; HT_HG-U133A	BAZ2A DHRS12 TBC1D2B	7.68e-04	198	21	3	5002_UP
Drug	Ald1.1-H_000455; Down 200; 10uM; MCF7; HT_HG-U133A	UBOX5 BAZ2A PRPF40A	7.68e-04	198	21	3	7516_DN
Drug	Sulfanilamide [63-74-1]; Down 200; 23.2uM; MCF7; HT_HG-U133A	UBOX5 DHRS12 TBC1D2B	7.79e-04	199	21	3	6810_DN
Drug	Captopril [62571-86-2]; Up 200; 17.2uM; MCF7; HT_HG-U133A	UBOX5 BAZ2A TBC1D2B	7.79e-04	199	21	3	1488_UP
Drug	Retrorsine [480-54-6]; Up 200; 11.4uM; MCF7; HT_HG-U133A	DHRS12 RIMBP2 MIA3	7.79e-04	199	21	3	4946_UP
Drug	Gliquidone [33342-05-1]; Up 200; 7.6uM; MCF7; HT_HG-U133A	BAZ2A DHRS12 SIGLEC1	7.79e-04	199	21	3	6505_UP
Drug	Ornidazole [16773-42-5]; Up 200; 18.2uM; HL60; HG-U133A	UBOX5 SIGLEC1 BAD	7.79e-04	199	21	3	1425_UP
Drug	Flurbiprofen [5104-49-4]; Up 200; 16.4uM; MCF7; HT_HG-U133A	BAZ2A TEX13B TBC1D2B	7.79e-04	199	21	3	5269_UP
Drug	Cefazolin sodium salt [27164-46-1]; Down 200; 8.4uM; HL60; HT_HG-U133A	UBOX5 DHRS12 DLC1	7.79e-04	199	21	3	2564_DN
Drug	Josamycin [16846-24-5]; Up 200; 4.8uM; MCF7; HT_HG-U133A	UBOX5 BAZ2A TEX13B	7.79e-04	199	21	3	1534_UP
Drug	Skimmianine [83-95-4]; Up 200; 15.4uM; PC3; HT_HG-U133A	OGDHL DHRS12 TBC1D2B	7.79e-04	199	21	3	5766_UP
Drug	Nisoxetine hydrochloride [57754-86-6]; Up 200; 13uM; MCF7; HT_HG-U133A	BAZ2A DLC1 TFR2	7.79e-04	199	21	3	5516_UP
Drug	tetraethylenepentamine pentahydrochloride; Down 200; 100uM; ssMCF7; HG-U133A	UBOX5 BAZ2A SIGLEC1	7.79e-04	199	21	3	498_DN
Drug	chlorpromazine hydrochloride; Up 200; 1uM; HL60; HT_HG-U133A	BAZ2A DLC1 TFR2	7.79e-04	199	21	3	2677_UP
Drug	Acetopromazine maleate salt [3598-37-6]; Down 200; 9uM; MCF7; HT_HG-U133A	UBOX5 BAZ2A TBC1D2B	7.79e-04	199	21	3	2769_DN
Drug	Perhexiline maleate [6724-53-4]; Up 200; 10.2uM; PC3; HT_HG-U133A	DNAH7 DHRS12 TFR2	7.79e-04	199	21	3	5081_UP
Drug	rapamycin, Streptomyces hygroscepicus; Up 200; 0.1uM; MCF7; HT_HG-U133A	BAZ2A DNAH7 TBC1D2B	7.79e-04	199	21	3	5927_UP
Drug	Zoxazolamine [61-80-3]; Up 200; 23.8uM; MCF7; HT_HG-U133A	BAZ2A TFR2 TBC1D2B	7.79e-04	199	21	3	2625_UP
Drug	Biperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A	BAZ2A MIA3 DLC1	7.79e-04	199	21	3	5644_DN
Drug	Tropine [120-29-6]; Up 200; 28.4uM; PC3; HT_HG-U133A	BAZ2A OGDHL DHRS12	7.79e-04	199	21	3	5790_UP
Drug	Amiloride hydrochloride dihydrate [17440-83-4]; Up 200; 13.2uM; MCF7; HT_HG-U133A	TFR2 TEX13B TBC1D2B	7.79e-04	199	21	3	1470_UP
Drug	Meprylcaine hydrochloride [956-03-6]; Up 200; 14.8uM; MCF7; HT_HG-U133A	UBOX5 DHRS12 TFR2	7.79e-04	199	21	3	3544_UP
Drug	Sulfamerazine [127-79-7]; Down 200; 15.2uM; HL60; HT_HG-U133A	BAZ2A TFR2 BAD	7.90e-04	200	21	3	2181_DN
Drug	Amiodarone hydrochloride [19774-82-4]; Up 200; 5.8uM; HL60; HT_HG-U133A	UBOX5 DLC1 TFR2	7.90e-04	200	21	3	2434_UP
Drug	Saquinavir mesylate [149845-06-7]; Up 200; 5.2uM; MCF7; HT_HG-U133A	UBOX5 BAZ2A SIGLEC1	7.90e-04	200	21	3	6246_UP
Drug	Sulfathiazole [72-14-0]; Up 200; 15.6uM; MCF7; HT_HG-U133A	OGDHL DLC1 TEX13B	7.90e-04	200	21	3	4769_UP
Drug	thioridazine hydrochloride; Down 200; 10uM; MCF7; HG-U133A	SIGLEC1 DLC1 TFR2	7.90e-04	200	21	3	417_DN
Disease	nicotine dependence	DLGAP3 HAX1	1.27e-03	78	20	2	EFO_0003768
Disease	allergic rhinitis	SLC25A46 DLC1	3.63e-03	133	20	2	EFO_0005854
Disease	emphysema imaging measurement	RIMBP2 DLC1	4.36e-03	146	20	2	EFO_0007626
Disease	platelet component distribution width	BAZ2A SIGLEC1 DLC1	1.37e-02	755	20	3	EFO_0007984

Protein segments in the cluster

Peptide	Gene	Start	Entry
MGEEPSPFRGRSRSA	BAD	86	Q92934
RREHFSFSPRMPVGD	BAZ2A	606	Q9UIF9
PRSHRDPFFGGMTRD	HAX1	16	O00165
EGMGPEHSSARPERF	OGDHL	771	Q9ULD0
ADGFLRRRPSMGHPG	PRPF40A	46	O75400
MRGYHGDRGSHPRPA	DLGAP3	1	O95886
PDSVRAFEHPGFIMR	DNAH7	391	Q8WXX0
MPGFHARFGDRLRSE	DHRS12	241	A0PJE2
TGHRYGPESPERREM	ENPP7	201	Q6UWV6
GRVDHMGRRFPRGSA	RIMBP2	796	O15034
FSHRGFKARPPFGAM	UBOX5	131	O94941
RRDMPRSEFGSVDGP	MIA3	1696	Q5JRA6
GRRFTFTAEHPGMRT	PLEKHA4	116	Q9H4M7
DPLERENFRHGPRFM	PPP1R32	161	Q7Z5V6
HGSELRDFPGRPMGH	DLC1	66	Q96QB1
MHPRRPDGFDGLGYR	SLC25A46	1	Q96AG3
ARFRGRTEFMGNPEH	SIGLEC1	81	Q9BZZ2
LRMVPEHRAFGSPFG	ZFYVE21	21	Q9BQ24
GGRRPSAPMTREEFL	TPGS1	261	Q6ZTW0
MSSFRPGRGHNDSRR	TBC1D2B	231	Q9UPU7
DSPFRHIFMGRGDHT	TFR2	726	Q9UP52
MALRPEDPSSGFRHG	TEX13B	1	Q9BXU2