Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionC2H2 zinc finger domain binding

MBD2 ZXDA ZXDB

2.71e-0517703GO:0070742
GeneOntologyMolecularFunctiontelomerase RNA binding

DHX36 GAR1 HNRNPU

8.98e-0525703GO:0070034
GeneOntologyMolecularFunctionbHLH transcription factor binding

BHLHE41 TCF15 SCX

2.94e-0437703GO:0043425
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2B KMT2A

3.35e-048702GO:0140945
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2B KMT2A

5.35e-0410702GO:0140999
GeneOntologyMolecularFunctionunmethylated CpG binding

KMT2B KMT2A

5.35e-0410702GO:0045322
GeneOntologyBiologicalProcessneuron projection morphogenesis

SEMA6B CACNA1A DHX36 ARHGEF40 GDF7 EFNB3 LZTS3 SYT3 AFG3L2 SRF SHOX2 SRCIN1 NYAP1 TLX2

2.82e-078026814GO:0048812
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

SEMA6B CACNA1A DHX36 ARHGEF40 GDF7 EFNB3 LZTS3 SYT3 AFG3L2 SRF SHOX2 SRCIN1 NYAP1 TLX2

3.64e-078196814GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

SEMA6B CACNA1A DHX36 ARHGEF40 GDF7 EFNB3 LZTS3 SYT3 AFG3L2 SRF SHOX2 SRCIN1 NYAP1 TLX2

4.03e-078266814GO:0048858
GeneOntologyBiologicalProcesscell morphogenesis

SEMA6B CACNA1A DHX36 BCL9L ARHGEF40 GDF7 EFNB3 LZTS3 SYT3 AFG3L2 SRF SHOX2 SRCIN1 NYAP1 RHOU TLX2

1.21e-0611946816GO:0000902
GeneOntologyBiologicalProcessneuron projection development

XYLT1 SEMA6B CACNA1A DHX36 ARHGEF40 GDF7 EFNB3 LZTS3 SYT3 AFG3L2 SRF SHOX2 NLGN2 SRCIN1 NYAP1 TLX2

3.16e-0612856816GO:0031175
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

SEMA6B CACNA1A DHX36 ARHGEF40 GDF7 EFNB3 LZTS3 AFG3L2 SRF SHOX2 SRCIN1 TLX2

5.34e-067486812GO:0048667
GeneOntologyBiologicalProcessRNA stabilization

DHX36 FUS PAIP1 HNRNPU METTL14

1.06e-0588685GO:0043489
GeneOntologyBiologicalProcessneuron development

XYLT1 SEMA6B CACNA1A DHX36 ARHGEF40 GDF7 EFNB3 LZTS3 SYT3 AFG3L2 SRF SHOX2 NLGN2 SRCIN1 NYAP1 TLX2

1.63e-0514636816GO:0048666
GeneOntologyBiologicalProcessnegative regulation of RNA catabolic process

DHX36 FUS PAIP1 HNRNPU METTL14

2.08e-05101685GO:1902369
GeneOntologyBiologicalProcesspositive regulation of cytoplasmic translation

DHX36 PAIP1 HNRNPU

2.25e-0517683GO:2000767
GeneOntologyBiologicalProcesstendon cell differentiation

GDF7 SCX

6.40e-054682GO:0035990
GeneOntologyBiologicalProcesstendon formation

GDF7 SCX

6.40e-054682GO:0035992
GeneOntologyBiologicalProcessregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

DHX36 PAIP1 HNRNPU

9.47e-0527683GO:1900151
GeneOntologyBiologicalProcessmRNA stabilization

FUS PAIP1 HNRNPU METTL14

1.22e-0477684GO:0048255
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

HJV BHLHE41 BPTF ZBTB46 SCRT1 ZBTB4 SRF SHOX2 ZBTB12 MBD2 SCX ZNF282 PRDM6 HNRNPU

1.58e-0413996814GO:0045892
GeneOntologyBiologicalProcessregulation of neuron projection development

XYLT1 CACNA1A DHX36 EFNB3 LZTS3 SRF SHOX2 SRCIN1 TLX2

1.74e-04612689GO:0010975
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

HJV BHLHE41 BPTF ZBTB46 SCRT1 ZBTB4 SRF SHOX2 ZBTB12 MBD2 SCX ZNF282 PRDM6 HNRNPU

1.75e-0414136814GO:1902679
GeneOntologyBiologicalProcessnegative regulation of mRNA catabolic process

FUS PAIP1 HNRNPU METTL14

1.96e-0487684GO:1902373
GeneOntologyBiologicalProcessgamma-aminobutyric acid signaling pathway

CACNA1A PLCL2 SHISA7

2.08e-0435683GO:0007214
GeneOntologyBiologicalProcessregulation of anatomical structure morphogenesis

CACNA1A DHX36 BCL9L EFNB3 LZTS3 SYT3 SRF SHOX2 SRCIN1 SCX RHOU TLX2

2.09e-0410906812GO:0022603
GeneOntologyBiologicalProcesstendon development

GDF7 SCX

2.23e-047682GO:0035989
GeneOntologyBiologicalProcessregulation of cytoplasmic translation

DHX36 PAIP1 HNRNPU

2.46e-0437683GO:2000765
GeneOntologyBiologicalProcessaxon development

XYLT1 SEMA6B CACNA1A ARHGEF40 GDF7 EFNB3 AFG3L2 SRF SHOX2

2.48e-04642689GO:0061564
GeneOntologyBiologicalProcesssynapse organization

CACNA1A DHX36 EFNB3 LZTS3 AFG3L2 HNRNPM NLGN2 SRCIN1 SHISA7

3.99e-04685689GO:0050808
GeneOntologyBiologicalProcessDNA methylation-dependent constitutive heterochromatin formation

KMT2B KMT2A MBD2

4.12e-0444683GO:0006346
GeneOntologyBiologicalProcessregulation of hematopoietic progenitor cell differentiation

DHX36 TCF15 METTL14

4.70e-0446683GO:1901532
GeneOntologyBiologicalProcessdendrite morphogenesis

CACNA1A DHX36 LZTS3 SRCIN1 TLX2

4.95e-04198685GO:0048813
GeneOntologyBiologicalProcessaxonogenesis

SEMA6B CACNA1A ARHGEF40 GDF7 EFNB3 AFG3L2 SRF SHOX2

5.32e-04566688GO:0007409
GeneOntologyBiologicalProcessnegative regulation of mRNA metabolic process

FUS PAIP1 HNRNPU METTL14

5.67e-04115684GO:1903312
GeneOntologyBiologicalProcessCRD-mediated mRNA stabilization

PAIP1 HNRNPU

5.78e-0411682GO:0070934
GeneOntologyBiologicalProcesspostsynapse organization

DHX36 LZTS3 HNRNPM NLGN2 SRCIN1 SHISA7

5.78e-04313686GO:0099173
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

HJV BHLHE41 BPTF ZBTB46 SCRT1 ZBTB4 SHOX2 ZBTB12 MBD2 PRDM6 HNRNPU

6.15e-0410536811GO:0000122
GeneOntologyBiologicalProcessnegative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

PAIP1 HNRNPU

6.92e-0412682GO:1900152
GeneOntologyBiologicalProcessfacultative heterochromatin formation

KMT2B KMT2A MBD2

7.95e-0455683GO:0140718
GeneOntologyBiologicalProcessdendrite development

CACNA1A DHX36 LZTS3 NLGN2 SRCIN1 TLX2

8.24e-04335686GO:0016358
GeneOntologyBiologicalProcessnegative regulation of hematopoietic progenitor cell differentiation

TCF15 METTL14

9.50e-0414682GO:1901533
DomainMeTrfase_trithorax

KMT2B KMT2A

1.42e-052712IPR016569
DomainFYrich_C

KMT2B KMT2A

1.41e-045712IPR003889
DomainFYrich_N

KMT2B KMT2A

1.41e-045712IPR003888
DomainFYRC

KMT2B KMT2A

1.41e-045712SM00542
DomainFYRN

KMT2B KMT2A

1.41e-045712SM00541
DomainFYRN

KMT2B KMT2A

1.41e-045712PF05964
DomainFYRC

KMT2B KMT2A

1.41e-045712PF05965
DomainFYRC

KMT2B KMT2A

1.41e-045712PS51543
DomainFYRN

KMT2B KMT2A

1.41e-045712PS51542
DomainBPI1

BPIFB3 BPIFB4

5.04e-049712SM00328
DomainLBP_BPI_CETP

BPIFB3 BPIFB4

5.04e-049712PS00400
DomainBPI2

BPIFB3 BPIFB4

5.04e-049712SM00329
DomainSET

KMT2B KMT2A PRDM6

5.06e-0441713PF00856
Domain-

EWSR1 FUS

6.29e-04107124.10.1060.10
DomainLBP_BPI_CETP_C

BPIFB3 BPIFB4

6.29e-0410712PF02886
DomainSET

KMT2B KMT2A PRDM6

7.11e-0446713SM00317
DomainZnf_CXXC

KMT2B KMT2A

7.66e-0411712IPR002857
DomainZF_CXXC

KMT2B KMT2A

7.66e-0411712PS51058
Domainzf-CXXC

KMT2B KMT2A

7.66e-0411712PF02008
DomainSET_dom

KMT2B KMT2A PRDM6

9.08e-0450713IPR001214
DomainSET

KMT2B KMT2A PRDM6

9.08e-0450713PS50280
DomainLipid-bd_serum_glycop_C

BPIFB3 BPIFB4

9.18e-0412712IPR001124
DomainLBP_BPI_CETP

BPIFB3 BPIFB4

1.08e-0313712PF01273
DomainBPI/LBP/Plunc

BPIFB3 BPIFB4

1.08e-0313712IPR032942
DomainBactericidal_perm-incr_a/b_dom

BPIFB3 BPIFB4

1.08e-0313712IPR017943
DomainLipid-bd_serum_glycop_N

BPIFB3 BPIFB4

1.08e-0313712IPR017942
DomainPost-SET_dom

KMT2B KMT2A

1.65e-0316712IPR003616
DomainPostSET

KMT2B KMT2A

1.65e-0316712SM00508
DomainPOST_SET

KMT2B KMT2A

1.65e-0316712PS50868
DomainZnf_FYVE_PHD

BPTF KMT2B ZBTB4 KMT2A

2.38e-03147714IPR011011
DomainPHD

BPTF KMT2B KMT2A

2.92e-0375713PF00628
Domainzf-RanBP

EWSR1 FUS

3.13e-0322712PF00641
DomainEPHD

KMT2B KMT2A

3.13e-0322712PS51805
DomainBTB

ZBTB46 ZBTB4 ZBTB12 KCTD2

3.23e-03160714PS50097
DomainZnf_PHD-finger

BPTF KMT2B KMT2A

3.39e-0379713IPR019787
DomainZnF_RBZ

EWSR1 FUS

3.42e-0323712SM00547
DomainZF_RANBP2_2

EWSR1 FUS

3.42e-0323712PS50199
DomainZF_RANBP2_1

EWSR1 FUS

3.73e-0324712PS01358
DomainZnf_RanBP2

EWSR1 FUS

4.04e-0325712IPR001876
Domain-

ZBTB46 SCRT1 ZBTB4 ZBTB12 ZNF282 ZXDA PRDM6 ZXDB

4.14e-036797183.30.160.60
Domainzf-C2H2

ZBTB46 SCRT1 ZBTB4 ZBTB12 ZNF282 ZXDA PRDM6 ZXDB

4.68e-03693718PF00096
DomainAT_hook

KMT2B KMT2A

4.70e-0327712SM00384
DomainAT_hook_DNA-bd_motif

KMT2B KMT2A

4.70e-0327712IPR017956
DomainZnf_C2H2/integrase_DNA-bd

ZBTB46 SCRT1 ZBTB4 ZBTB12 ZNF282 ZXDA PRDM6 ZXDB

4.72e-03694718IPR013087
DomainPHD

BPTF KMT2B KMT2A

4.73e-0389713SM00249
DomainBTB

ZBTB46 ZBTB4 ZBTB12 KCTD2

4.91e-03180714SM00225
DomainZnf_PHD

BPTF KMT2B KMT2A

5.04e-0391713IPR001965
DomainBTB/POZ_dom

ZBTB46 ZBTB4 ZBTB12 KCTD2

5.40e-03185714IPR000210
DomainZF_PHD_2

BPTF KMT2B KMT2A

5.68e-0395713PS50016
DomainSKP1/BTB/POZ

ZBTB46 ZBTB4 ZBTB12 KCTD2

5.82e-03189714IPR011333
DomainZF_PHD_1

BPTF KMT2B KMT2A

5.84e-0396713PS01359
DomainHMGI/Y_DNA-bd_CS

EWSR1 MBD2

6.17e-0331712IPR000637
DomainRRM_1

HNRNPM EWSR1 FUS HNRNPLL

8.12e-03208714PF00076
Domain-

BHLHE41 TCF15 SCX

8.29e-031097134.10.280.10
DomainHLH

BHLHE41 TCF15 SCX

8.71e-03111713PF00010
DomainZINC_FINGER_C2H2_2

ZBTB46 SCRT1 ZBTB4 ZBTB12 ZNF282 ZXDA PRDM6 ZXDB

8.99e-03775718PS50157
Pubmed

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes.

AVEN KMT2B KMT2A

3.26e-08471326267306
Pubmed

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.

OSBP GAR1 FUS MBD2 PRRC2A PAIP1

5.88e-0714771628977470
Pubmed

ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center.

HNRNPM EWSR1 FUS HNRNPU

2.44e-064671420890123
Pubmed

KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions.

KMT2B KMT2A

4.11e-06271228723559
Pubmed

Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.

EWSR1 FUS

4.11e-0627128921363
Pubmed

Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies.

ZXDA ZXDB

4.11e-0627128268913
Pubmed

Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma.

BPTF METTL14

4.11e-06271233664855
Pubmed

EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.

EWSR1 FUS

4.11e-06271226573619
Pubmed

Chromatin remodeling complex NURF regulates thymocyte maturation.

BPTF SRF

4.11e-06271221289071
Pubmed

An RNAi screen unravels the complexities of Rho GTPase networks in skin morphogenesis.

KRT5 RHOU

4.11e-06271231556874
Pubmed

A morphologic and molecular reappraisal of myoepithelial tumors of soft tissue, bone, and viscera with EWSR1 and FUS gene rearrangements.

EWSR1 FUS

4.11e-06271231994243
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

PPP1R10 BPTF KMT2B KMT2A ZNF282

4.68e-0611971523508102
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CACNA1A DHX36 KRT5 DPP6 LZTS3 SYT3 AFG3L2 HNRNPM KMT2A EWSR1 SRCIN1 PRRC2A HNRNPU

5.76e-061431711337142655
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

DHX36 PPP1R10 HNRNPM EWSR1 FUS PRRC2A HNRNPU

6.24e-0634071724332808
Pubmed

GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.

DHX36 CAPNS1 EWSR1 KCTD2 FUS PRRC2A

6.57e-0622371633731348
Pubmed

Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.

KRT5 HNRNPM FUS PAIP1 HNRNPU

8.99e-0613671526979993
Pubmed

Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.

PPP1R10 HNRNPM EWSR1 FUS PRRC2A HNRNPU

1.10e-0524471629884807
Pubmed

FUS-NFATC2 or EWSR1-NFATC2 Fusions Are Present in a Large Proportion of Simple Bone Cysts.

EWSR1 FUS

1.23e-05371232991339
Pubmed

Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population.

ZBTB12 PRRC2A

1.23e-05371223079975
Pubmed

Selective interactions of hnRNP M isoforms with the TET proteins TAF15 and TLS/FUS.

HNRNPM FUS

1.23e-05371224474660
Pubmed

The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response.

EWSR1 FUS

1.23e-05371218620564
Pubmed

Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides.

BPIFB3 BPIFB4

1.23e-05371212837268
Pubmed

mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.

EWSR1 FUS

1.23e-05371221344536
Pubmed

A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins.

EWSR1 FUS

1.23e-05371223975937
Pubmed

A Subset of Malignant Mesotheliomas in Young Adults Are Associated With Recurrent EWSR1/FUS-ATF1 Fusions.

EWSR1 FUS

1.23e-05371228505004
Pubmed

Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis.

EWSR1 FUS

1.23e-05371227311318
Pubmed

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.

EWSR1 FUS

1.23e-05371221856723
Pubmed

Unclassified low grade spindle cell sarcoma with storiform pattern characterized by recurrent novel EWSR1/FUS-NACC1 fusions.

EWSR1 FUS

1.23e-05371233859361
Pubmed

Role of FET proteins in neurodegenerative disorders.

EWSR1 FUS

1.23e-05371227415968
Pubmed

Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors.

EWSR1 FUS

1.23e-05371225706482
Pubmed

Ewing sarcoma with ERG gene rearrangements: A molecular study focusing on the prevalence of FUS-ERG and common pitfalls in detecting EWSR1-ERG fusions by FISH.

EWSR1 FUS

1.23e-05371226690869
Pubmed

SRE elements are binding sites for the fusion protein EWS-FLI-1.

SRF EWSR1

1.23e-0537128604338
Pubmed

Cytokeratin-positive Malignant Tumor in the Abdomen With EWSR1/FUS-CREB Fusion: A Clinicopathologic Study of 8 Cases.

EWSR1 FUS

1.23e-05371234049318
Pubmed

O-GlcNAc glycosylation stoichiometry of the FET protein family: only EWS is glycosylated with a high stoichiometry.

EWSR1 FUS

1.23e-05371227903134
Pubmed

Characterization of a new brain-specific isoform of the EWS oncoprotein.

EWSR1 FUS

1.23e-05371211422378
Pubmed

Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions.

EWSR1 FUS

1.23e-05371238168093
Pubmed

Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions.

EWSR1 FUS

1.23e-05371223049996
Pubmed

Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.

EWSR1 FUS HNRNPU

1.40e-052371318320585
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

DHX36 HNRNPM EWSR1 FUS HNRNPLL PRRC2A

1.50e-0525871637794589
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

CACNA1A BCL9L OSBP LZTS3 AFG3L2 HNRNPM USP24 SRCIN1 HNRNPLL SHISA7 HNRNPU

1.88e-051139711136417873
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

DHX36 HNRNPM EWSR1 FUS PRRC2A HNRNPU

2.11e-0527471634244482
Pubmed

Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation.

EWSR1 FUS

2.46e-05471228453628
Pubmed

Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites.

TCF15 SCX

2.46e-0547127729571
Pubmed

FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements.

SRF EWSR1

2.46e-0547129010223
Pubmed

Characterization of TFG in mus musculus and Caenorhabditis elegans.

EWSR1 FUS

2.46e-05471210092511
Pubmed

Integration of CREB and bHLH transcriptional signaling pathways through direct heterodimerization of the proteins: role in muscle and testis development.

TCF15 SCX

2.46e-05471218361414
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2B KMT2A

2.46e-05471223129768
Pubmed

Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation.

KMT2B KMT2A

2.46e-05471217166833
Pubmed

Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA.

KMT2B KMT2A

2.46e-05471234156981
Pubmed

WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.

KMT2B KMT2A

2.46e-05471218840606
Pubmed

Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma.

HNRNPM MBD2

2.46e-05471235158098
Pubmed

The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex.

EWSR1 FUS

2.46e-05471230398641
Pubmed

MLL1 is required for PAX7 expression and satellite cell self-renewal in mice.

KMT2B KMT2A

2.46e-05471231534153
Pubmed

The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.

EWSR1 FUS

2.46e-0547129660765
Pubmed

Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.

KMT2B KMT2A

2.46e-05471225834037
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CACNA1A LZTS3 SYT3 HNRNPM EWSR1 NLGN2 FUS PRRC2A SHISA7 HNRNPU

2.53e-05963711028671696
Pubmed

A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.

KRT5 HNRNPM EWSR1 KCTD2 FUS HNRNPU

2.68e-0528671632041737
Pubmed

EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3.

HNRNPM EWSR1 FUS PRRC2A HNRNPU

2.95e-0517471535031058
Pubmed

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

EWSR1 FUS HNRNPU

3.18e-053071315782174
Pubmed

Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer.

HNRNPM EWSR1 FUS HNRNPU

3.27e-058871426318153
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

PPP1R10 GAR1 CAPNS1 HNRNPM USP24 EWSR1 PRRC2A HNRNPU

3.65e-0561571831048545
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

DHX36 PPP1R10 GAR1 HNRNPM EWSR1 FUS HNRNPLL PRRC2A HNRNPU

3.84e-0580771922681889
Pubmed

Evolving Catalytic Properties of the MLL Family SET Domain.

KMT2B KMT2A

4.09e-05571226320581
Pubmed

Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.

KMT2B KMT2A

4.09e-05571225561738
Pubmed

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

KMT2B KMT2A

4.09e-05571228609655
Pubmed

IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.

EWSR1 FUS

4.09e-05571218648544
Pubmed

Mohawk is a novel homeobox gene expressed in the developing mouse embryo.

TCF15 SCX

4.09e-05571216408284
Pubmed

The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

CACNA1A TMEM121B SHOX2

4.26e-053371319336002
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

DHX36 HNRNPM EWSR1 FUS HNRNPLL PRRC2A HNRNPU

4.46e-0546271731138677
Pubmed

Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations.

GAR1 HNRNPM FUS HNRNPU

4.60e-059671425948554
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

DHX36 PPP1R10 KRT5 GAR1 CAPNS1 AFG3L2 HNRNPM EWSR1 FUS HNRNPU METTL14

4.61e-051257711136526897
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

RABL6 CACNA1A SYT3 TMEM121B USP24 PRRC2A SHISA7

5.31e-0547571731040226
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

PPP1R10 BPTF KMT2B GAR1 AFG3L2 HNRNPM KMT2A EWSR1 FUS MBD2 HNRNPU

5.99e-051294711130804502
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

KRT5 ARHGEF40 KMT2A PRRC2A HNRNPU

6.00e-0520271524639526
Pubmed

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.

EWSR1 FUS

6.13e-05671218509338
Pubmed

The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.

EWSR1 FUS

6.13e-05671230354839
Pubmed

Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.

KMT2B KMT2A

6.13e-05671224176642
Pubmed

MLL associates specifically with a subset of transcriptionally active target genes.

KMT2B KMT2A

6.13e-05671216199523
Pubmed

Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.

DHX36 HNRNPM EWSR1 FUS HNRNPU

6.58e-0520671522174317
Pubmed

A cohesin-RAD21 interactome.

MSRB2 OSBP TCF15 EWSR1 HNRNPU

6.89e-0520871522145905
Pubmed

Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.

KRT5 HNRNPM FUS HNRNPU

7.02e-0510771432989256
Pubmed

Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.

DHX36 HNRNPM HNRNPU

7.63e-054071323825951
Pubmed

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

DHX36 KRT5 HNRNPM EWSR1 FUS HNRNPU

7.72e-0534671625324306
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

CACNA1A TMEM121B NLGN2 SRCIN1 TRAPPC14 PRRC2A

7.84e-0534771617114649
Pubmed

PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx.

BPIFB3 BPIFB4

8.57e-05771211971875
Pubmed

Expression of a twist-related gene, Bbtwist, during the development of a lancelet species and its relation to cephalochordate anterior structures.

TCF15 SCX

8.57e-0577129520323
Pubmed

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.

KRT5 LZTS3 AFG3L2 HNRNPM FUS HNRNPU

8.61e-0535371627545878
Pubmed

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

DHX36 LZTS3 FUS PRRC2A HNRNPU

8.97e-0522071524550385
Pubmed

A census of human transcription factors: function, expression and evolution.

BHLHE41 TCF15 ZBTB4 SRF KMT2A SHOX2 ONECUT3 ZNF282 TLX2

9.48e-0590871919274049
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

DHX36 GAR1 HNRNPM FUS HNRNPLL PRRC2A PAIP1 HNRNPU

1.02e-0471371829802200
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

KMT2B KMT2A

1.14e-04871223130995
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

KMT2B KMT2A

1.14e-04871222266653
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

BHLHE41 SCRT1 SRF ZBTB12 ONECUT3 ZNF282 TLX2

1.23e-0454471728473536
Pubmed

Identification of DeltaNp63alpha protein interactions by mass spectrometry.

KRT5 ZBTB4 FUS

1.32e-044871320085233
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

DHX36 KRT5 GAR1 CAPNS1 AFG3L2 HNRNPM USP24 EWSR1 FUS PRRC2A HNRNPU

1.32e-041415711128515276
Pubmed

Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.

DHX36 GAR1 HNRNPM KCTD2 FUS PRRC2A

1.36e-0438471631059266
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

PPP1R10 BPTF GAR1 HNRNPM KMT2A EWSR1 FUS PRRC2A HNRNPU

1.38e-0495471936373674
Pubmed

Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.

HNRNPM FUS MBD2

1.40e-044971327352031
Pubmed

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.

KRT5 AFG3L2 HNRNPM KCTD2 FUS PRRC2A HNRNPU

1.44e-0455871727591049
Pubmed

PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.

FUS HNRNPU

1.47e-04971211850402
InteractionRBM45 interactions

KRT5 AFG3L2 HNRNPM EWSR1 FUS PAIP1 HNRNPU

7.55e-06207707int:RBM45
InteractionKDM5B interactions

CACNA1A TMEM121B KMT2A SHOX2 MBD2

2.55e-05100705int:KDM5B
InteractionWDR77 interactions

OSBP GAR1 HNRNPM FUS MBD2 PRRC2A PAIP1 METTL14

3.52e-05361708int:WDR77
InteractionCAPN13 interactions

PPP1R10 EWSR1 PRRC2A

3.74e-0519703int:CAPN13
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2B KMT2A PRDM6

1.41e-0434543487
GeneFamilyZinc fingers CXXC-type

KMT2B KMT2A

5.67e-0412542136
GeneFamilyBPI fold containing

BPIFB3 BPIFB4

1.02e-0316542456
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZBTB46 SCRT1 ZBTB4 ZBTB12 ZNF282 ZXDA PRDM6 ZXDB

1.23e-0371854828
GeneFamilyZinc fingers RANBP2-type |RNA binding motif containing

EWSR1 FUS

1.77e-032154289
GeneFamilyPHD finger proteins

BPTF KMT2B KMT2A

2.46e-039054388
GeneFamilyRNA binding motif containing

HNRNPM EWSR1 FUS HNRNPLL

3.74e-03213544725
GeneFamilyBasic helix-loop-helix proteins

BHLHE41 TCF15 SCX

4.34e-03110543420
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ZBTB46 ZBTB4 ZBTB12

7.50e-03134543861
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A GJD2 C3orf80 SRCIN1 ONECUT3

8.41e-0617371507798461d12d04f3dabff03481c999cb07c5af2f
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A GJD2 C3orf80 SRCIN1 ONECUT3

8.41e-06173715f31e738c2b3b319fb40b0b16b2393a51c9a8999c
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B3_(IPAN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 SCRT1 SRCIN1 NYAP1 TLX2

9.14e-0617671504dad262929581872e5bbc66cd8182c963e7e52f
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

XYLT1 SHOX2 HNRNPU ZXDB FAM43A

9.40e-06177715eb0cfe8e9a91910f9979608ed47add48d98ce4dd
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DPP6 RUNDC3B TMEM121B SRCIN1 TLX2

9.92e-06179715af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCL9L CAPNS1 SRF FUS PRRC2A

1.19e-05186715bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A TMEM121B SRCIN1 NYAP1 SHISA7

1.43e-05193715be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A TMEM121B SRCIN1 NYAP1 SHISA7

1.43e-051937150c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A TMEM121B SRCIN1 NYAP1 SHISA7

1.43e-051937158689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DHX36 USP24 KMT2A FUS HNRNPU

1.58e-0519771557ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

XYLT1 DPP6 LZTS3 USP24 SHISA7

1.65e-0519971519a97e27a4758e794ce7246d295e112b47931a48
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

XYLT1 DPP6 LZTS3 USP24 SHISA7

1.65e-05199715333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

XYLT1 DPP6 LZTS3 USP24 SHISA7

1.65e-05199715e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCellMild/Remission-B_naive-13|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

KRT5 NLGN2 ZBTB12 ONECUT3

7.84e-0514271449873a2d9b1ae4bdbf253d1c09bf8845cc0cc917
ToppCellMild/Remission-B_naive-13|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

KRT5 NLGN2 ZBTB12 ONECUT3

8.50e-051457147827aef87f834cd0d19780417757c9386e19b22e
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue-9|TCGA-Colorectal / Sample_Type by Project: Shred V9

DPP6 EPM2A PRDM6 PDZRN4

1.21e-04159714f376bf6cd0ed374211edac3c384f3a78f0caef2a
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A USP24 NLGN2 PDZRN4

1.37e-04164714b895674ed2df87db8fbfb30b7e31620945588491
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue|TCGA-Colorectal / Sample_Type by Project: Shred V9

DPP6 EPM2A PRDM6 PDZRN4

1.53e-0416971491f4b6a14708e701b2af22989004282041777491
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue|TCGA-Colorectal / Sample_Type by Project: Shred V9

DPP6 EPM2A PRDM6 PDZRN4

1.53e-0416971441cb92b0558f0d5a3e511058efd9110258b88ee3
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A TMEM121B C3orf80 ONECUT3

1.57e-0417071402f0be0aab8ba2d35a83238609352ef3677511c9
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BHLHE41 CACNA1A CBLC ONECUT3

1.57e-04170714985c2d5962100fab0d95bee39f382ccbe799331e
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 SCRT1 SRF SRCIN1

1.72e-04174714271c51d220842402975d97c86c9acfdbdf62a32c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XYLT1 NLGN2 NYAP1 SHISA7

1.75e-041757141d1cdbf3221b03e24eae38afd57cbd6736b37a53
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A DPP6 C3orf80 ONECUT3

1.75e-04175714c031da47ca63d1133e13530cbf779df9435e22cb
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XYLT1 NLGN2 NYAP1 SHISA7

1.75e-04175714d67c77eee979ad029e7545f383326f0ff77c6e5f
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_A|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 SCRT1 RUNDC3B TLX2

1.79e-04176714116741fef5895ca85057d2d31eca9eba5764ab44
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A TMEM121B C3orf80 ONECUT3

1.79e-041767142e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 SCRT1 RUNDC3B TLX2

1.79e-041767145b707f58d164ee7a6a527dd5d053472ce9a631c1
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 SYT3 RUNDC3B SHISA7

1.91e-04179714228d12ed1c8dc92aefbcea4aaf7d108783c22be0
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BHLHE41 MAN1A1 CBLC FAM43A

1.95e-04180714d8135f73a89b97168f2048258f4648e23536ece4
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-Zbtb32+_B_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BHLHE41 MAN1A1 CBLC FAM43A

1.95e-04180714c12c1cc206f7e63e5722471bd3eb84caddb84129
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

XYLT1 DPP6 SCRT1 TLX2

1.99e-041817147f99002a6411117cc2361334c7c9228e20c574b4
ToppCellPCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DPP6 GJD2 RUNDC3B TLX2

2.12e-04184714571136c832cb8c08457744152231537aa8e8abd7
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XYLT1 DPP6 NLGN2 PDZRN4

2.12e-041847148d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A GJD2 MAN1A1 ONECUT3

2.12e-041847141e6f86f9e379cd9f453f6b7185f681b44eb63e09
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XYLT1 DPP6 NLGN2 PDZRN4

2.12e-04184714278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DPP6 RUNDC3B SRCIN1 TLX2

2.21e-04186714cf96f880e6e22189593ce1357c55e65c34644559
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A TMEM121B NYAP1 SHISA7

2.21e-041867147278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Cd9_(Mural.Rgs5Acta2.Cd9)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

HJV KRT5 CBLC

2.25e-04747137c7e45cf219b0be5cf0d0e5ea5daeb32284c8ccd
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Cd9_(Mural.Rgs5Acta2.Cd9)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

HJV KRT5 CBLC

2.25e-04747136183baf43010268f54a6db9332296338f4f74009
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

PPP1R10 USP24 KMT2A FUS

2.31e-04188714ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XYLT1 DPP6 SHISA7 PDZRN4

2.31e-04188714a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XYLT1 DPP6 SHISA7 PDZRN4

2.31e-04188714c8530c9ff98666c64a94683261af4288cb790a7e
ToppCellwk_15-18-Epithelial-PNS-PCP4+_neuron|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DPP6 GJD2 RUNDC3B TLX2

2.35e-0418971422c927d2691b867fbdee1fbee042a6d3f7eadd7d
ToppCell(3)_Chondrocytes-(31)_Chondro-hyper|World / Cell class and subclass of bone marrow stroma cells in homeostatis

XYLT1 BHLHE41 SHOX2 PRDM6

2.35e-04189714394b153393904c3dba51a6bfe338afd554e66649
ToppCellPCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DPP6 SCRT1 RUNDC3B TLX2

2.35e-04189714de06ef69f3f97b3f21dc269eb6965da9b2f6e3f8
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XYLT1 DPP6 SHISA7 PDZRN4

2.40e-041907149b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XYLT1 DPP6 SHISA7 PDZRN4

2.40e-04190714d146af1926474328a7c822bc140c4dda66e1bbfb
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 RUNDC3B SRCIN1 TLX2

2.50e-04192714fe9297cb65234d9f511bab1a5dbf2679d5a4cd15
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAN1A1 USP24 PAIP1 HNRNPU

2.55e-0419371406b65110db974f4ef90d3511ff34428976a52c9c
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAN1A1 USP24 PAIP1 HNRNPU

2.55e-041937149c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 RUNDC3B SRCIN1 TLX2

2.55e-04193714a189d46c39067b717509cd144e0225cc93d7731d
ToppCellfacs-Brain_Myeloid-Hippocampus-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAN1A1 USP24 PAIP1 HNRNPU

2.55e-04193714a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 SCRT1 RUNDC3B TLX2

2.55e-041937148851275bcf4ecd6e87a91c8784fc5d76d246ff3b
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAN1A1 USP24 PAIP1 HNRNPU

2.55e-04193714b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell10x3'2.3-week_14-16-Lymphocytic_B-B_lineage-pro_B_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MAN1A1 HNRNPM EWSR1 FAM43A

2.60e-04194714f64da5f62e29253d60b9546edf734ba5c17daae1
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 SYT3 ONECUT3 TLX2

2.65e-041957145a6a5048af638872700b76b7c71a8fa3fb8d3772
ToppCellwk_08-11-Epithelial-PNS-TM4SF4+_PENK+_neuron|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

DPP6 GJD2 RUNDC3B TLX2

2.70e-04196714afa3a2f5f3a51d1830c6f95f97a4b3e13ed42512
ToppCellCV-Moderate-6|CV / Virus stimulation, Condition and Cluster

DHX36 BPTF CAPNS1 KMT2A

2.70e-041967147bced0cc2112697593c478fa291b8ed3941fb811
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 SYT3 RUNDC3B TLX2

2.75e-04197714b9478212f14b7888e3abac02995177974ac3bd17
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 SCRT1 RUNDC3B TLX2

2.75e-04197714c220102fadbb7ba385a61704a144e0b814cb5c46
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 RUNDC3B SRCIN1 TLX2

2.81e-0419871485881637641d8996be2edc65c4bceff0433135e7
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

DHX36 BPTF KMT2A PDZRN4

2.81e-04198714de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BPTF USP24 FUS HNRNPU

2.86e-04199714f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellHSPCs|World / Lineage and Cell class

GAR1 HNRNPM EWSR1 HNRNPU

2.86e-04199714df1ffc416c6946f1ba182f242a50ee41a571d565
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

XYLT1 BPTF EFNB3 KMT2A

2.86e-04199714358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

XYLT1 DPP6 LZTS3 SHISA7

2.92e-04200714ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

XYLT1 CACNA1A DPP6 PDZRN4

2.92e-042007144fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

XYLT1 CACNA1A DPP6 PDZRN4

2.92e-04200714f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

XYLT1 CACNA1A DPP6 PDZRN4

2.92e-04200714cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

XYLT1 CACNA1A DPP6 PDZRN4

2.92e-04200714310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

SCRT1 EFNB3 KMT2A NLGN2

2.92e-04200714c92e4fc0442404481fcac623d691dae6215b852d
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

XYLT1 CACNA1A DPP6 PDZRN4

2.92e-04200714c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Mesenchymal-Mesoderm|GW13 / Sample Type, Dataset, Time_group, and Cell type.

CACNA1A DPP6 EFNB3 TRAPPC14

2.92e-042007140f4b8b0868bda406fe6bf01d1b722510fdfd0168
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BPTF KMT2A FUS HNRNPU

2.92e-0420071412f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal-Unfolded_protein_responsible_cell|GW12 / Sample Type, Dataset, Time_group, and Cell type.

FZD8 EPM2A GAR1 PLCL2

2.92e-042007146b7314c425f6b40f1301dd39cc02b0436e96a2ec
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

XYLT1 CACNA1A DPP6 PDZRN4

2.92e-04200714961858738ce35db8760c8c2e136f8369bc444ccf
Diseaseprogressive myoclonus epilepsy (is_implicated_in)

SEMA6B EPM2A

1.57e-053682DOID:891 (is_implicated_in)
Diseaseamyotrophic lateral sclerosis type 6 (implicated_via_orthology)

EWSR1 FUS

1.57e-053682DOID:0060198 (implicated_via_orthology)
Diseaseparenchymal hematoma, response to recombinant tissue-plasminogen activator

ZBTB46 PDZRN4

7.80e-056682EFO_0020101, EFO_0600080
Diseasechronic kidney disease, Proteinuria

CACNA1A KMT2A

2.84e-0411682EFO_0003884, HP_0000093
Diseasecarbamazepine-induced hyponatremia, response to carbamazepine

RUNDC3B PLCL2

2.84e-0411682EFO_0008484, EFO_0009894
DiseaseAmyotrophic Lateral Sclerosis

DPP6 EWSR1 FUS

3.30e-0458683C0002736
Diseasefrontotemporal dementia (implicated_via_orthology)

EWSR1 FUS

3.40e-0412682DOID:9255 (implicated_via_orthology)
DiseaseFamilial Progressive Myoclonic Epilepsy

EPM2A AFG3L2

6.96e-0417682C0751777
DiseaseAtypical Inclusion-Body Disease

EPM2A AFG3L2

6.96e-0417682C0751776
DiseaseMyoclonic Epilepsies, Progressive

EPM2A AFG3L2

6.96e-0417682C0751778
DiseaseBiotin-Responsive Encephalopathy

EPM2A AFG3L2

6.96e-0417682C0751780
DiseaseMay-White Syndrome

EPM2A AFG3L2

6.96e-0417682C0751782
DiseaseDentatorubral-Pallidoluysian Atrophy

EPM2A AFG3L2

6.96e-0417682C0751781
DiseaseAction Myoclonus-Renal Failure Syndrome

EPM2A AFG3L2

7.82e-0418682C0751779
DiseaseDystonia

CACNA1A KMT2B AFG3L2

1.04e-0386683C0013421
Diseaselevel of Sterol ester (27:1/16:0) in blood serum

USP24 CBLC

1.64e-0326682OBA_2045191
DiseaseBarrett's esophagus

DPP6 GDF7

1.90e-0328682EFO_0000280
DiseaseAmyotrophic Lateral Sclerosis With Dementia

DPP6 FUS

2.04e-0329682C0393554
Diseaseamyotrophic lateral sclerosis (implicated_via_orthology)

EWSR1 FUS

2.18e-0330682DOID:332 (implicated_via_orthology)
DiseaseEpileptic encephalopathy

CACNA1A HNRNPU

2.18e-0330682C0543888

Protein segments in the cluster

PeptideGeneStartEntry
GSGGGRGAGGSRQGG

CACNA1A

26

O00555
DRGGFGGGRRGGPGG

EWSR1

606

Q01844
GGGAGRGGAGPRGHV

EPM2A

121

B3EWF7
SGGLLGGGGLLGHGG

BPIFB3

66

P59826
RPGELRGGGGGGQGA

ARHGEF40

351

Q8TER5
GPGGTGGGGSGGGKR

GJD2

126

Q9UKL4
SRRAAGGGGPGGPGG

CBLC

61

Q9ULV8
RSSGGGGGGGGKRGG

AFG3L2

106

Q9Y4W6
LGGGGLLGDGGLLGG

BPIFB4

191

P59827
KLDSRGGGSGGGPGG

BHLHE41

281

Q9C0J9
STSAPGRGGRGGGGG

BPTF

86

Q12830
GRGGRGGGGGRTGGG

BPTF

91

Q12830
RGGGARGGPPGGRWG

PDZRN4

141

Q6ZMN7
LGGGAPGGRHPGGGD

RABL6

711

Q3YEC7
GGSSGALRGGGGGGR

HJV

56

Q6ZVN8
ALRGGGGGGRGGGVG

HJV

61

Q6ZVN8
TPRGGGDGGGGGRSF

HNRNPLL

46

Q8WVV9
MGRPGHLGSGEGGGG

LZTS3

291

O60299
SGGYEPRGRGGGRGG

FUS

236

P35637
GGRGGGDRGGFGPGK

FUS

496

P35637
SDRGGGAPRGGGRGG

METTL14

406

Q9HCE5
GLGGGLGGGLGGGLA

KRT5

511

P13647
GGGGGGSVPGIERMG

HNRNPM

391

P52272
MPQRGGGGGGSGGIG

HNRNPU

736

Q00839
PGRPRGAGGGGGRGG

KMT2B

21

Q9UMN6
GPPVVGGGGGRGDAG

OSBP

26

P22059
SRGLGRGGGGPEGGG

PAIP1

16

Q9H074
GGGGGGGGEGRGAPR

PRDM6

151

Q9NQX0
RPPSGGSGLGGDGGG

MBD2

96

Q9UBB5
CGGGGSGGGGAPRRE

MBD2

111

Q9UBB5
PHRGGGRGGGGGDAA

FZD8

191

Q9H461
GARGGRGGGGAPRGS

AVEN

61

Q9NQS1
RDGGPRSSGGGYGGG

DHX36

11

Q9H2U1
GGGGGGRGGRGRHPG

DHX36

41

Q9H2U1
GGGGGLGGGLGNVLG

CAPNS1

16

P04632
GLRPDAPGGGGGGGG

BCL9L

216

Q86UU0
GGGGRGRGGGGRSDP

C3orf80

161

F5H4A9
RGEALGGGGGSLGPG

FAM43A

321

Q8N2R8
GVLGGGLGGGGGRKG

MAN1A1

16

P33908
GLGGGGGRKGSGPAA

MAN1A1

21

P33908
ARPGTTGGGGGGGRR

KMT2A

11

Q03164
TGGGGGGGRRGLGGA

KMT2A

16

Q03164
AAPRERGGGGGGAGG

DPP6

51

P42658
PGSFGRGGSLGLGGG

EFNB3

266

Q15768
RGGSLGLGGGGGMGP

EFNB3

271

Q15768
LAGAQRGGGGPGGGA

NLGN2

11

Q8NFZ4
GRGVGPGAGPGAGDG

IL17RC

776

Q8NAC3
GGGSGVGDGGGPVRG

KCTD2

16

Q14681
RGLPGGGGGTGSGGA

ONECUT3

261

O60422
GGGRSGGGLAGPPLG

NYAP1

226

Q6ZVC0
GPPRGGGRGGRGGGR

GAR1

166

Q9NY12
LGGLSGIRGGGGGGG

RUNDC3B

6

Q96NL0
QGTGPGGRRSGGGPG

SYT3

276

Q9BQG1
GGRRSGGGPGSGEAG

SYT3

281

Q9BQG1
GGGGAGGRSLGSGPG

SCRT1

151

Q9BWW7
GGRSLGSGPGGRGGT

SCRT1

156

Q9BWW7
GSGPGGRGGTRAGAG

SCRT1

161

Q9BWW7
STSRGGGGGRRGGGG

TMEM121B

51

Q9BXQ6
GGGGRRGGGGGSPSS

TMEM121B

56

Q9BXQ6
GGGGGGGGGGRTLAQ

GDF7

41

Q7Z4P5
GVGEGGGGGGRLGHG

PLCL2

31

Q9UPR0
GGGPGGRTGPGRGDK

PRRC2A

1416

P48634
GGAGGGAGGGRSPVR

SHOX2

81

O60902
GGAGGRGGEGPGGST

SHISA7

171

A6NL88
GGGGGTRGANGGRVP

SRF

31

P11831
GGRGGRGPGEPGGRG

RHOU

26

Q7L0Q8
PGPGGGRRAGGGGGA

TCF15

51

Q12870
ERRAQGPGGRGGGGG

SEMA6B

656

Q9H3T3
GGGGGIPAGGGRVHR

ZXDB

16

P98169
GGGGGRGPQARARGG

XYLT1

86

Q86Y38
PGGLGGGLGIGGSVG

ZBTB12

226

Q9Y330
VRGQAGGGGPGTGPG

MSRB2

21

Q9Y3D2
LGGGGGGGSGGRRFS

SRCIN1

31

Q9C0H9
RCRGGAGSGTGGGPG

TRAPPC14

51

Q8WVR3
GRGTGGGPGGPEGGD

SLC12A9

846

Q9BXP2
GGGREPGGGRGKSGS

ZBTB4

881

Q9P1Z0
GGGGGIPAGGGRVHR

ZXDA

16

P98168
RGDGGGDGGGGGPSR

USP24

71

Q9UPU5
AGGRRAGGGGPGGRP

SCX

56

Q7RTU7
LLSGRGGGGGGGGGA

nan

91

Q6ZS46
RGGRSGGGPPNGRGG

PPP1R10

726

Q96QC0
PGGDRSTGGGGGDGG

ZNF282

466

Q9UDV7
GRGMAGPLDHGGGGG

ZBTB46

506

Q86UZ6
PGGGLGLGRGGQGHG

TLX2

31

O43763