Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	methionine adenosyltransferase activity	MAT1A MAT2A	1.71e-05	2	83	2	GO:0004478
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	FEM1B CUL2 KLHDC3	1.21e-05	12	80	3	GO:0140627
GeneOntologyCellularComponent	methionine adenosyltransferase complex	MAT1A MAT2A	4.66e-05	3	83	2	GO:0048269
MousePheno	abnormal tongue morphology	SLC35A3 DSG3 WNT5A STAC3 FGF9 POU2F3 ITGB4	1.97e-06	118	70	7	MP:0000762
Domain	Quinoprot_gluc/sorb_DH	HHIPL2 LRP1 HHIPL1	1.68e-05	12	81	3	IPR011041
Domain	S-AdoMet_synt_M	MAT1A MAT2A	1.86e-05	2	81	2	PF02772
Domain	S-AdoMet_synt_C	MAT1A MAT2A	1.86e-05	2	81	2	PF02773
Domain	ADOMET_SYNTHASE_CS	MAT1A MAT2A	1.86e-05	2	81	2	IPR022631
Domain	S-AdoMet_synt_C	MAT1A MAT2A	1.86e-05	2	81	2	IPR022630
Domain	S-AdoMet_synthetase_sfam	MAT1A MAT2A	1.86e-05	2	81	2	IPR022636
Domain	S-AdoMet_synt_N	MAT1A MAT2A	1.86e-05	2	81	2	PF00438
Domain	S-AdoMet_synt_central	MAT1A MAT2A	1.86e-05	2	81	2	IPR022629
Domain	S-AdoMet_synt_N	MAT1A MAT2A	1.86e-05	2	81	2	IPR022628
Domain	S-AdoMet_synthetase	MAT1A MAT2A	1.86e-05	2	81	2	IPR002133
Domain	ADOMET_SYNTHASE_1	MAT1A MAT2A	1.86e-05	2	81	2	PS00376
Domain	ADOMET_SYNTHASE_2	MAT1A MAT2A	1.86e-05	2	81	2	PS00377
Domain	MORN	MORN1 ALS2 ANKMY1	2.76e-05	14	81	3	SM00698
Domain	MORN	MORN1 ALS2 ANKMY1	3.44e-05	15	81	3	IPR003409
Domain	MORN	MORN1 ALS2 ANKMY1	3.44e-05	15	81	3	PF02493
Domain	Glc/Sorbosone_DH	HHIPL2 HHIPL1	5.56e-05	3	81	2	IPR012938
Domain	GSDH	HHIPL2 HHIPL1	5.56e-05	3	81	2	PF07995
Domain	Desmoglein	DSG1 DSG3	1.11e-04	4	81	2	IPR009123
Domain	FN3	PAPPA2 COL12A1 RIMBP2 ITGB4 HCFC1 PTPRT	1.53e-04	185	81	6	SM00060
Domain	FN3_dom	PAPPA2 COL12A1 RIMBP2 ITGB4 HCFC1 PTPRT	2.95e-04	209	81	6	IPR003961
Domain	Desmosomal_cadherin	DSG1 DSG3	3.85e-04	7	81	2	IPR009122
Domain	Folate_rcpt-like	HHIPL2 HHIPL1	5.11e-04	8	81	2	IPR018143
Domain	Folate_rec	HHIPL2 HHIPL1	5.11e-04	8	81	2	PF03024
Domain	-	HHIPL2 LRP1 HHIPL1	6.42e-04	39	81	3	2.120.10.30
Domain	6-blade_b-propeller_TolB-like	HHIPL2 LRP1 HHIPL1	1.04e-03	46	81	3	IPR011042
Domain	Kelch_2	KLHDC3 HCFC1	1.40e-03	13	81	2	IPR011498
Domain	6-hairpin_glycosidase-like	TREH GBA2	1.40e-03	13	81	2	IPR008928
Domain	Kelch_2	KLHDC3 HCFC1	1.40e-03	13	81	2	PF07646
Domain	FN3	COL12A1 RIMBP2 ITGB4 HCFC1 PTPRT	1.74e-03	199	81	5	PS50853
Domain	ConA-like_dom	PAPPA2 COL12A1 LAMA1 ITGB4 PTPRT	2.63e-03	219	81	5	IPR013320
Domain	ZF_DAG_PE_1	STAC3 DGKA TNS2	2.71e-03	64	81	3	PS00479
Domain	ZF_DAG_PE_2	STAC3 DGKA TNS2	2.71e-03	64	81	3	PS50081
Domain	C1	STAC3 DGKA TNS2	2.83e-03	65	81	3	SM00109
Domain	PE/DAG-bd	STAC3 DGKA TNS2	2.95e-03	66	81	3	IPR002219
Domain	RCC1	ALS2 HERC2	3.36e-03	20	81	2	PF00415
Domain	RCC1_1	ALS2 HERC2	3.70e-03	21	81	2	PS00625
Domain	RCC1_2	ALS2 HERC2	3.70e-03	21	81	2	PS00626
Domain	RCC1_3	ALS2 HERC2	3.70e-03	21	81	2	PS50012
Domain	FGF	FGF20 FGF9	4.06e-03	22	81	2	SM00442
Domain	Reg_chr_condens	ALS2 HERC2	4.06e-03	22	81	2	IPR000408
Domain	-	ALS2 HERC2	4.06e-03	22	81	2	2.130.10.30
Domain	FGF	FGF20 FGF9	4.06e-03	22	81	2	PF00167
Domain	HBGF_FGF	FGF20 FGF9	4.06e-03	22	81	2	PS00247
Domain	Fibroblast_GF_fam	FGF20 FGF9	4.06e-03	22	81	2	IPR002209
Domain	IL-1_fam/FGF_fam	FGF20 FGF9	4.43e-03	23	81	2	IPR028142
Domain	RCC1/BLIP-II	ALS2 HERC2	4.43e-03	23	81	2	IPR009091
Domain	Cadherin_cytoplasmic-dom	DSG1 DSG3	5.22e-03	25	81	2	IPR000233
Domain	Cadherin_C	DSG1 DSG3	5.22e-03	25	81	2	PF01049
Domain	fn3	COL12A1 RIMBP2 ITGB4 PTPRT	5.41e-03	162	81	4	PF00041
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	FEM1B CUL2 STK11 TTC28 SND1 DSG1 CLTA WDR70 NUFIP2 LRP1 RIMBP2 HERC2 EIF3J PFKP HCFC1	1.43e-08	1005	83	15	19615732
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	CUL2 DNAJC10 SND1 MAT1A MAT2A WDR70 SARDH PFKP POU2F3 HCFC1	1.27e-07	451	83	10	36168627
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CUL2 ACSL3 SLC9C1 SND1 DCTN2 CTR9 PI4KB CLTA WDR70 NUFIP2 LARS1 SCYL1 PFKP RSPH9 VTI1B	4.91e-07	1321	83	15	27173435
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	CUL2 ACSL3 SND1 DSG1 DCTN2 MAT2A HEBP1 CLTA LRP1 GLOD4 EIF3J PFKP HCFC1 SNX1 GOT2	7.55e-07	1367	83	15	32687490
Pubmed	Network organization of the human autophagy system.	ATG101 CUL2 STK11 SND1 PI4KB CLTA LARS1 PFKP VTI1B	1.04e-06	437	83	9	20562859
Pubmed	The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.	FEM1B CUL2 KLHDC3	1.55e-06	10	83	3	29779948
Pubmed	Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis.	DSG1 DSG3 ITGB4	2.13e-06	11	83	3	21844209
Pubmed	Epithelial Migration and Non-adhesive Periderm Are Required for Digit Separation during Mammalian Development.	DSG1 LAMA1 GRHL3	4.68e-06	14	83	3	32109382
Pubmed	Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus.	DSG1 DSG3	5.63e-06	2	83	2	28620161
Pubmed	Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3.	DSG1 DSG3	5.63e-06	2	83	2	17640963
Pubmed	Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer.	ACSL3 MAT2A	5.63e-06	2	83	2	35182729
Pubmed	Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris.	DSG1 DSG3	5.63e-06	2	83	2	21602032
Pubmed	Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.	MAT1A MAT2A	5.63e-06	2	83	2	22318685
Pubmed	Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation.	DSG1 DSG3	5.63e-06	2	83	2	12485422
Pubmed	Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions.	DSG1 DSG3	5.63e-06	2	83	2	11120754
Pubmed	The mapping of linear B-cell epitope regions in the extracellular parts of the desmoglein 1 and 3 proteins: recognition of immobilized peptides by pemphigus patients' serum autoantibodies.	DSG1 DSG3	5.63e-06	2	83	2	23297065
Pubmed	S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells.	MAT1A MAT2A	5.63e-06	2	83	2	27076759
Pubmed	Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells.	HPGD WNT5A	5.63e-06	2	83	2	27522468
Pubmed	The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12.	DSG1 DSG3	5.63e-06	2	83	2	8034325
Pubmed	A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.	MAT1A MAT2A	5.63e-06	2	83	2	29749642
Pubmed	Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin.	DSG1 DSG3	5.63e-06	2	83	2	35711465
Pubmed	Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix.	FGF20 FGF9	5.63e-06	2	83	2	19564416
Pubmed	The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.	LRP1 BACE1	5.63e-06	2	83	2	15749709
Pubmed	Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.	MAT1A MAT2A	5.63e-06	2	83	2	31234428
Pubmed	The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1.	LRP1 BACE1	5.63e-06	2	83	2	20685197
Pubmed	Expression of desmoglein 1 compensates for genetic loss of desmoglein 3 in keratinocyte adhesion.	DSG1 DSG3	5.63e-06	2	83	2	12164920
Pubmed	Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.	MAT1A MAT2A	5.63e-06	2	83	2	29448301
Pubmed	Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens.	DSG1 DSG3	5.63e-06	2	83	2	9405290
Pubmed	Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion.	DSG1 DSG3	5.63e-06	2	83	2	1720352
Pubmed	Desmoplakin is essential in epidermal sheet formation.	DSG1 DSG3 ITGB4	8.70e-06	17	83	3	11781569
Pubmed	Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.	FEM1B CUL2 KLHDC3	1.04e-05	18	83	3	18187417
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	CUL2 ACSL3 COL12A1 DNAJC10 SND1 MAT2A CLTA NUFIP2 LARS1 PFKP HCFC1 SNX1 GOT2	1.19e-05	1297	83	13	33545068
Pubmed	Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.	MAT1A MAT2A	1.69e-05	3	83	2	23425511
Pubmed	LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling.	WNT5A LRP1	1.69e-05	3	83	2	18990694
Pubmed	Multiple species of mammalian S-adenosylmethionine synthetase. Partial purification and characterization.	MAT1A MAT2A	1.69e-05	3	83	2	7213623
Pubmed	Deciphering the Role of the rs2651899, rs10166942, and rs11172113 Polymorphisms in Migraine: A Meta-Analysis.	LRP1 TRPM8	1.69e-05	3	83	2	35454329
Pubmed	BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma.	FEM1B CUL2	1.69e-05	3	83	2	33299012
Pubmed	Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation.	DSG1 DSG3	1.69e-05	3	83	2	12787134
Pubmed	Genetics of migraine in the age of genome-wide association studies.	LRP1 TRPM8	1.69e-05	3	83	2	22072275
Pubmed	Structure and function study of the complex that synthesizes S-adenosylmethionine.	MAT1A MAT2A	1.69e-05	3	83	2	25075345
Pubmed	Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition†.	MAT1A MAT2A	1.69e-05	3	83	2	30265288
Pubmed	Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins.	DSG1 DSG3	1.69e-05	3	83	2	8143788
Pubmed	Genome-wide association study reveals three susceptibility loci for common migraine in the general population.	LRP1 TRPM8	1.69e-05	3	83	2	21666692
Pubmed	Expression of desmogleins 1-3 and their clinical impacts on human lung cancer.	DSG1 DSG3	1.69e-05	3	83	2	25468811
Pubmed	Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment.	DSG1 DSG3	1.69e-05	3	83	2	7738346
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	SND1 DSG1 MAT2A HPGD CLTA SCYL1 HHIPL1 GLOD4 PFKP GOT2	2.17e-05	803	83	10	36517590
Pubmed	Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms.	EOMES FGF20 FGF9	2.24e-05	23	83	3	20713518
Pubmed	Regulation of desmocollin transcription in mouse preimplantation embryos.	DSG1 DSG3	3.37e-05	4	83	2	7536656
Pubmed	The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease.	MAT2A BACE1	3.37e-05	4	83	2	22879628
Pubmed	Expression patterns of laminin receptor splice variants alpha 6A beta 1 and alpha 6B beta 1 suggest different roles in mouse development.	LAMA1 ITGB4	3.37e-05	4	83	2	8573717
Pubmed	Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6.	DSG1 DSG3	3.37e-05	4	83	2	12787123
Pubmed	Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.	LRP1 BACE1	3.37e-05	4	83	2	19251705
Pubmed	Desmoglein as a target in skin disease and beyond.	DSG1 DSG3	3.37e-05	4	83	2	22189787
Pubmed	Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris.	DSG1 DSG3	3.37e-05	4	83	2	12705872
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	CUL2 SND1 DSG1 CTR9 MAT2A WDR70 GOT2	4.95e-05	400	83	7	35013556
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FEM1B ARFGEF3 TTC28 NUFIP2 ALS2 RIMBP2 ADGRL3	5.52e-05	407	83	7	12693553
Pubmed	cDNA cloning and chromosomal assignment of the mouse gene for desmoglein 3 (Dsg3), the pemphigus vulgaris antigen.	DSG1 DSG3	5.60e-05	5	83	2	7894164
Pubmed	Conversion of ES cells to columnar epithelia by hensin and to squamous epithelia by laminin.	DSG1 LAMA1	5.60e-05	5	83	2	15452149
Pubmed	The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells.	WNT5A LRP1	5.60e-05	5	83	2	23011131
Pubmed	COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels.	LRP1 BACE1	5.60e-05	5	83	2	23926111
Pubmed	Nomenclature of the desmosomal cadherins.	DSG1 DSG3	5.60e-05	5	83	2	8486729
Pubmed	SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.	COL12A1 DNAJC10 DSG1 NUFIP2 PFKP	6.10e-05	173	83	5	23979707
Pubmed	Liver and brain differential expression of one-carbon metabolism genes during ontogenesis.	MAT1A MAT2A SARDH	6.79e-05	33	83	3	34702858
Pubmed	Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF.	FGF20 LAMA1 FGF9	8.12e-05	35	83	3	34032268
Pubmed	Essential role of alpha 6 integrins in cortical and retinal lamination.	LAMA1 ITGB4	8.39e-05	6	83	2	9742403
Pubmed	Protein kinase C isoenzymes differentially regulate the differentiation-dependent expression of adhesion molecules in human epidermal keratinocytes.	DSG1 DSG3	8.39e-05	6	83	2	18637128
Pubmed	Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1.	STK11 HERC2	8.39e-05	6	83	2	27259994
Pubmed	Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse.	DSG1 DSG3	8.39e-05	6	83	2	9404003
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	DNAJC10 SND1 DSG1 DCTN2 CTR9 MAT2A CLTA LARS1 DNAH7 HCFC1 GOT2	9.22e-05	1153	83	11	29845934
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	ACSL3 DNAJC10 SND1 DSG1 LARS1 PFKP	1.05e-04	312	83	6	37120454
Pubmed	CRL2KLHDC3 mediates p14ARF N-terminal ubiquitylation degradation to promote non-small cell lung carcinoma progression.	CUL2 KLHDC3	1.17e-04	7	83	2	35468939
Pubmed	The tumor-suppressor function of E-cadherin.	DSG1 DSG3	1.17e-04	7	83	2	9837810
Pubmed	FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.	FGF20 FGF9	1.17e-04	7	83	2	22698282
Pubmed	Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart.	FGF20 FGF9	1.17e-04	7	83	2	18816849
Pubmed	Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling.	FGF20 FGF9	1.17e-04	7	83	2	22833125
Pubmed	Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.	LRP1 BACE1	1.17e-04	7	83	2	17920016
Pubmed	Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.	DSG1 DSG3 FAM3D	1.31e-04	41	83	3	16740002
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	PRR12 DNAJC10 DSG1 WDR70 NUFIP2 HERC2 EIF3J	1.44e-04	475	83	7	31040226
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CUL2 ARFGEF3 ACSL3 DNAJC10 SND1 DCTN2 CLTA LARS1 EIF3J PFKP HCFC1 VTI1B	1.55e-04	1440	83	12	30833792
Pubmed	Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha.	MAT1A MAT2A	1.56e-04	8	83	2	19158324
Pubmed	Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse.	NCALD GRHL3	1.56e-04	8	83	2	21262862
Pubmed	Localization of the homolog of a mouse craniofacial mutant to human chromosome 18q11 and evaluation of linkage to human CLP and CPO.	DSG1 DSG3	1.56e-04	8	83	2	8786128
Pubmed	ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.	FEM1B CUL2 DNAJC10 KLHDC3 CTR9 CLTA	1.57e-04	336	83	6	31253590
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	ACSL3 MORN1 SND1 DCTN2 CTR9 SCYL1 EIF3J SNX1	1.69e-04	653	83	8	33742100
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	CUL2 DNAJC10 SND1 NUFIP2 LARS1 PFKP HCFC1	1.83e-04	494	83	7	26831064
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	CUL2 ACSL3 DNAJC10 SND1 DSG1 DCTN2 CTR9 MAT2A LARS1 PFKP HCFC1	1.96e-04	1257	83	11	37317656
Pubmed	FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.	ATG101 DNAJC10 NUFIP2 LARS1 HERC2	2.00e-04	223	83	5	34226595
Pubmed	Integrin β4 regulation of PTHrP underlies its contribution to mammary gland development.	LAMA1 ITGB4	2.00e-04	9	83	2	26432258
Pubmed	Regulation of neural stem cell proliferation and survival by protein arginine methyltransferase 1.	EOMES LAMA1	2.00e-04	9	83	2	36440275
Pubmed	A Cellular Mechanism to Detect and Alleviate Reductive Stress.	FEM1B CUL2	2.00e-04	9	83	2	32941802
Pubmed	Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the receptor protein of CRL2Prame complex.	FEM1B CUL2 KLHDC3	2.10e-04	48	83	3	33504946
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	ADPRS DNAJC10 SND1 HEBP1 LARS1 LRP1 GLOD4 HCFC1 GOT2	2.11e-04	859	83	9	31536960
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	DSG1 CTR9 WDR70 NUFIP2 HCFC1 SNX1	2.18e-04	357	83	6	37059091
Pubmed	An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).	MAT1A MAT2A SARDH	2.23e-04	49	83	3	19161160
Pubmed	Vti1b promotes TRPV1 sensitization during inflammatory pain.	SND1 NUFIP2 PFKP VTI1B	2.49e-04	127	83	4	30335684
Pubmed	FEM1 proteins are ancient regulators of SLBP degradation.	FEM1B CUL2	2.50e-04	10	83	2	28118078
Pubmed	Genetic patterning of the posterior neuropore region of curly tail mouse embryos: deficiency of Wnt5a expression.	WNT5A GRHL3	2.50e-04	10	83	2	9712518
Pubmed	Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.	DSG1 DSG3	2.50e-04	10	83	2	12724416
Pubmed	Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.	EOMES PFKP	2.50e-04	10	83	2	18194653
Pubmed	Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth.	WNT5A FGF9	2.50e-04	10	83	2	12591596
Cytoband	12q13.3	DCTN2 STAC3 LRP1 DGKA	2.33e-06	51	83	4	12q13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	ATG101 DCTN2 STAC3 LRP1 DGKA TNS2	1.23e-04	423	83	6	chr12q13
Cytoband	18q12.1	DSG1 DSG3	1.02e-03	26	83	2	18q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr9p13	CLTA SHB GBA2	3.94e-03	174	83	3	chr9p13
GeneFamily	Desmosomal cadherins	DSG1 DSG3	1.82e-04	7	54	2	1188
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 COL12A1 OTOGL LAMA1 DISP3 ADGRL3	1.25e-06	184	83	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 COL12A1 OTOGL LAMA1 DISP3 ADGRL3	1.25e-06	184	83	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 COL12A1 OTOGL LAMA1 DISP3 ADGRL3	1.25e-06	184	83	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NCALD COL12A1 WNT5A FGF9 PTPRT ADGRL3	1.92e-06	198	83	6	d83707b69fb64721ac3cff90ba58cdd999d6b386
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRPH2 TNS2 CPT1B POU2F3 ADGRL3	4.35e-06	129	83	5	2f30b4897343586c9b49a1d2bec3007ec737085c
ToppCell	facs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOGL MAT1A LAMA1 PRPH2 SEC14L2	6.72e-06	141	83	5	4aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCell	facs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOGL MAT1A LAMA1 PRPH2 SEC14L2	6.72e-06	141	83	5	e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCell	facs-Heart-Unknown-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOGL MAT1A LAMA1 PRPH2 SEC14L2	6.95e-06	142	83	5	759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT2_Precursor\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ARFGEF3 MAT1A SHB CTSH SEC14L2	1.06e-05	155	83	5	9cad73d0b8ead289e1073d1a2e00bbeb1228308c
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 LAMA1 TRPM8 RIMBP2 PTPRT	1.24e-05	160	83	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 LAMA1 TRPM8 RIMBP2 PTPRT	1.24e-05	160	83	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDKL2 HPGD LRP1 DGKA AFG1L	1.91e-05	175	83	5	c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 CDKL2 RIMBP2 PFKP DNAH7	2.83e-05	190	83	5	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARFGEF3 CDKL2 PPIL6 CTSH DNAH7	3.05e-05	193	83	5	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	Control-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	SLC9C1 PPIL6 DNAH7 RSPH9 PTPRT	3.13e-05	194	83	5	958e648138676d46698090b4046cb484083ae449
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Ciliated\|Control_saline / Treatment groups by lineage, cell group, cell type	TREH MAT1A PPIL6 ANKMY1 DNAH7	3.21e-05	195	83	5	60067b5359174f0d1a8b5748bfc0690762e9e740
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Mucous-Mucous\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARFGEF3 ACSL3 SLC35A3 DNAJC10 FAM3D	3.29e-05	196	83	5	357a5440aeebf69688bfe9fbc8585950ad00906b
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Mucous\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARFGEF3 ACSL3 SLC35A3 DNAJC10 FAM3D	3.29e-05	196	83	5	98e3f9c886063def16c74ab75fc81511a7872f1c
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	ARFGEF3 SLC9C1 DNAH7 RSPH9 PTPRT	3.29e-05	196	83	5	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MORN1 MAT1A PPIL6 ANKMY1 DNAH7	3.62e-05	200	83	5	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	Children_(3_yrs)-Immune-mast_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DSG3 SIGLEC8 HPGD ALS2	1.60e-04	146	83	4	f7349d63bb47f1f22ced8ff514edc1c11bc782e7
ToppCell	Club_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	ARFGEF3 SIGLEC8 WNT5A FAM3D	1.64e-04	147	83	4	5a824c89e4d045af465d7333275f8191fb29b041
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	STK11 LAMA1 DNAH7 SLC5A3	1.64e-04	147	83	4	f5109e0f4e8b46a977a763c9c72a2df9840e3977
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	STK11 LAMA1 DNAH7 SLC5A3	1.64e-04	147	83	4	ad0c575bc9c5f201f2a7810452e8b3f741e65d89
ToppCell	Adult-Mesenchymal-chondrocyte-D122\|Adult / Lineage, Cell type, age group and donor	PRPH2 TNS2 RIMBP2 ADGRL3	1.69e-04	148	83	4	81a1e6fdd942a612bf523c59b8b4974f6ca1fdce
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	EOMES STAC3 NUFIP2 SHB	1.82e-04	151	83	4	4533bccc996395f74b16af939ce79b6fe253c073
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	EOMES STAC3 NUFIP2 SHB	1.82e-04	151	83	4	edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCell	frontal_cortex\|World / Per Region, Lineage, Cell class, Cell type, Cell subtype	PAPPA2 COL12A1 HPGD FGF9	1.87e-04	152	83	4	f9c29d4568402ca07a717dbffb3ccc7f35c5fe56
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NCALD COL12A1 FGF20 PRPH2	2.07e-04	156	83	4	d5207dbfbcfb885557ea1378dfe6a56d7102e94a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NCALD COL12A1 FGF20 PRPH2	2.07e-04	156	83	4	363f1b661048d25895e2b8681c82894c957b29c0
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 HPGD STAC3 HHIPL2	2.12e-04	157	83	4	7fdc0094dd5729990a91a30c1982a14c74650b52
ToppCell	Children_(3_yrs)-Immune-mast_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DSG3 SIGLEC8 HPGD ALS2	2.12e-04	157	83	4	ec185dbeabb67fd9ca85f71cab88463b60f9b1c1
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-microglial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 HPGD STAC3 HHIPL2	2.12e-04	157	83	4	c762b03e254c73222094725ca8ac1c8eb428bccb
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 HPGD STAC3 HHIPL2	2.12e-04	157	83	4	6b5b08bb5520fcf6f4c0560f7ed7645ec179806d
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-SMG_basal_1\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	LAMA1 POU2F3 FAM3D ITGB4	2.17e-04	158	83	4	adad97e6cf479d42791c5ba9cbc5f15f469322bf
ToppCell	18-Airway-Epithelial-Bud_tip_progenitor\|Airway / Age, Tissue, Lineage and Cell class	DSG3 FGF20 FGF9 CPT1B	2.22e-04	159	83	4	e715cadff8e7d5ebe4c2198dbdfd3ca41ecb8a6a
ToppCell	21-Trachea-Epithelial-Submucosal_gland_basal\|Trachea / Age, Tissue, Lineage and Cell class	COL12A1 LAMA1 SHB FGF9	2.22e-04	159	83	4	4f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARFGEF3 ACSL3 WNT5A RIMBP2	2.27e-04	160	83	4	af84da18c85037f49f55e8958f00f12140226982
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARFGEF3 ACSL3 WNT5A RIMBP2	2.27e-04	160	83	4	f7ca98beaa24f9674d503588eb15d341c4135d77
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARFGEF3 ACSL3 WNT5A RIMBP2	2.27e-04	160	83	4	a76ad44b5f25f59d6b9333fb45f8bb96196a3090
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 ARFGEF3 SLC9C1 RIMBP2	2.33e-04	161	83	4	4bb7bae54ba3bdf46b525c01f5ad3db8e49819cb
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MORN1 OTOGL HEBP1 LRP1	2.33e-04	161	83	4	60f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EOMES NCALD COL12A1 HHIPL1	2.44e-04	163	83	4	bbc078761c5043af13d9a6fcf3145a3e300bae5e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EOMES NCALD COL12A1 HHIPL1	2.44e-04	163	83	4	8e32b6431e1862572663aa6ddc4ea299c6acc8a6
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EOMES NCALD KIFC3 PFKP	2.50e-04	164	83	4	9fed5df40f50bde35db8bf89c291cbdc0e104112
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	ARFGEF3 CDKL2 OTOGL CTSH	2.50e-04	164	83	4	beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL12A1 WNT5A TVP23A ADGRL3	2.50e-04	164	83	4	a764b79a127c8f360af0b79a1da64658badf0dfa
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	ARFGEF3 CDKL2 OTOGL CTSH	2.50e-04	164	83	4	d005cfd821b87548b075120bffe65a0be9860463
ToppCell	Ciliated_cells-A-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	DNAH7 FAM3D RSPH9 PTPRT	2.56e-04	165	83	4	0ebdbbdb151fb797335013d5838af1c7bbc45b06
ToppCell	ILEUM-non-inflamed-(4)_Mast\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SIGLEC8 HPGD ALS2 POU2F3	2.68e-04	167	83	4	de0cb257def6049830af068f8f74829a708b810f
ToppCell	ILEUM-non-inflamed-(4)_Mast_cells\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SIGLEC8 HPGD ALS2 POU2F3	2.68e-04	167	83	4	85b39e05eb6e18e06b47e374d808e479ca65173c
ToppCell	10x5'-lymph-node_spleen-Mast-Mast_cells\|lymph-node_spleen / Manually curated celltypes from each tissue	SIGLEC8 HPGD ALS2 RSPH9	2.74e-04	168	83	4	650ad3ea52577887885d82457dbc04202ce3eb34
ToppCell	10x5'-lymph-node_spleen-Mast\|lymph-node_spleen / Manually curated celltypes from each tissue	SIGLEC8 HPGD ALS2 RSPH9	2.74e-04	168	83	4	e58ffbb57c81967766755c3f6f347b158a39cb0d
ToppCell	Severe-B_memory-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SND1 STAC3 PFKP CTSH	2.74e-04	168	83	4	85a36e1b994a8fd2f589563f011913e4944dc1cd
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 HPGD LRP1 CTSH	2.80e-04	169	83	4	44d841fd997a6f26104f16cd00223ecce8352f43
ToppCell	severe-Myeloid-Eosinophils\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SIGLEC8 HPGD SHB ALS2	2.87e-04	170	83	4	863f0266d5837cdbc3e09a3fe6a99dd3e6261674
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HPGD GRHL3 FAM3D ITGB4	2.93e-04	171	83	4	59b9dbaa05b6e5740edc633c9ce1181565550d5b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HPGD GRHL3 FAM3D ITGB4	2.93e-04	171	83	4	a5b9dd2b6a54db7962beeb5a9ceb9dacfb613fa7
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAT1A HEBP1 SEC14L2 GOT2	3.00e-04	172	83	4	feaaf8ca7983d04a59ed0a7b3fb0e6d4b3a055f2
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAT1A HEBP1 SEC14L2 GOT2	3.00e-04	172	83	4	9adfb4a65669cc536343616637058d0a4728013f
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAT1A HEBP1 SEC14L2 GOT2	3.00e-04	172	83	4	8aed9c113f27d00401c272a3684495a4bc75bd0f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARFGEF3 LAMA1 FGF9 KIFC3	3.00e-04	172	83	4	1565f38266891c3acf49778838de134c5dee5460
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal-Basal-Basal_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DSG3 GRHL3 FAM3D ITGB4	3.06e-04	173	83	4	1b2508cc890430bd4b2cf232c633928edb86c57e
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-skeletal_muscle_satellite_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC9C1 OTOGL RIMBP2 PTPRT	3.13e-04	174	83	4	f230d23618a6487f2664efb2c677e0a4559e2bf4
ToppCell	(03)_Secretory-(0)_uninjured\|(03)_Secretory / shred by cell type and Timepoint	ARFGEF3 TTC28 CTSH SEC14L2	3.13e-04	174	83	4	ebdddb5091afcc49ab533c890f260f709880c5f9
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NCALD COL12A1 PFKP PTPRT	3.20e-04	175	83	4	06af6629766e2054e6995e8cdb3907658fec49d3
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	FEM1B DSG3 LRP1 GRHL3	3.20e-04	175	83	4	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-basophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SIGLEC8 HPGD SHB ALS2	3.20e-04	175	83	4	ba1befc4e5f0167452f9ceace39377d16136dfa9
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_3\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 GRHL3 FAM3D ITGB4	3.27e-04	176	83	4	8d9d0fb46c418b2067be58aec822e8c2b1561461
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 SLC9C1 DISP3 RIMBP2	3.27e-04	176	83	4	2e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4-POLYDENDROCYTE_(Neurogenesis.Sox4.Gabra5)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EOMES PAPPA2 OTOGL	3.29e-04	72	83	3	480653f8bd0ef118cb8d541103692e3ec8a1b58d
ToppCell	15-Airway-Epithelial-Multiciliated_precursor\|Airway / Age, Tissue, Lineage and Cell class	MAT1A PPIL6 DNAH7 RSPH9	3.41e-04	178	83	4	d8e0a696bdd6af6422d72af0413f9dbd6bc02afa
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCALD FGF9 FAM3D PTPRT	3.48e-04	179	83	4	7c8a2fa1326c73dc9e774df645b572864fd97133
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 FGF20 DISP3 RIMBP2	3.48e-04	179	83	4	d70791d2a0db35a6b013fa7ed2f9f39364581eff
ToppCell	Ciliated_cells-A-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	PPIL6 DNAH7 RSPH9 PTPRT	3.48e-04	179	83	4	0e6c22de2e3fb0ff23b3301863cf4011c5c59dff
ToppCell	AT1-AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	GRHL3 ITGB4 ADGRL3 SEC14L2	3.56e-04	180	83	4	3c7b2033821f9e34e2924bd8655f566edcbcc7d3
ToppCell	Ciliated_cells-A-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	PPIL6 DNAH7 RSPH9 PTPRT	3.56e-04	180	83	4	d9be152773fe9f2160edad9246fa03c03afeafd6
ToppCell	severe-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SIGLEC8 HPGD SHB ALS2	3.56e-04	180	83	4	ac03812b1409435c55d323a7516deeac82bd3509
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal-Basal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DSG3 GRHL3 FAM3D ITGB4	3.63e-04	181	83	4	6b43dcaeeb02ad5900772b6f16f1581847050e38
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PPIL6 DNAH7 RSPH9 PTPRT	3.63e-04	181	83	4	dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DSG3 GRHL3 FAM3D ITGB4	3.63e-04	181	83	4	f50561fdacfb83ba85fe6476e7cbc2bad1ebc826
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	MAT1A DNAH7 RSPH9 PTPRT	3.71e-04	182	83	4	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HPGD WNT5A GRHL3 ITGB4	3.71e-04	182	83	4	678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HPGD WNT5A GRHL3 ITGB4	3.71e-04	182	83	4	8d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCell	367C-Epithelial_cells-Epithelial-F_(Ciliated)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	PPIL6 DNAH7 RSPH9 PTPRT	3.79e-04	183	83	4	b1336eac5adbffade4cef3e0ce3de75a781ae365
ToppCell	367C-Epithelial_cells-Epithelial-F_(Ciliated)\|367C / Donor, Lineage, Cell class and subclass (all cells)	PPIL6 DNAH7 RSPH9 PTPRT	3.79e-04	183	83	4	cc57dcb59c68d68a546dc108dd9e009b2aab8da5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NCALD COL12A1 PFKP PTPRT	3.87e-04	184	83	4	9cc5c588f7c6631b3fb8a522214a09ca32947e72
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 FGF20 LAMA1 RIMBP2	3.87e-04	184	83	4	fa4915b0498f3069fd5ef497286445528f75187e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9C1 HPGD RIMBP2 PFKP	3.95e-04	185	83	4	a0a629e5d2b65f670ea907bd3f5e3caf17687d8f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARFGEF3 LAMA1 FGF9 KIFC3	3.95e-04	185	83	4	03f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	PPIL6 DNAH7 RSPH9 PTPRT	3.95e-04	185	83	4	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NCALD COL12A1 PFKP PTPRT	3.95e-04	185	83	4	a1b2525da018abe458908cab7268bd403ee98d92
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	PPIL6 DNAH7 RSPH9 PTPRT	3.95e-04	185	83	4	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARFGEF3 LAMA1 FGF9 KIFC3	4.03e-04	186	83	4	1850583d23903d08226aeb0edb3e07b0994330e4
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARFGEF3 SLC9C1 CDKL2 POU2F3	4.03e-04	186	83	4	acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCell	390C-Epithelial_cells-Epithelial-F_(Ciliated)\|390C / Donor, Lineage, Cell class and subclass (all cells)	PPIL6 DNAH7 RSPH9 PTPRT	4.03e-04	186	83	4	708c5edefe36c91df27cf53c1b5101fb2030cc5a
ToppCell	390C-Epithelial_cells-Epithelial-F_(Ciliated)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	PPIL6 DNAH7 RSPH9 PTPRT	4.03e-04	186	83	4	029390c4aaf64e6bcd86124cd4a6dd2e6f3a374b
ToppCell	Ciliated_cells-B-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	PPIL6 DNAH7 RSPH9 PTPRT	4.11e-04	187	83	4	2b4262c2e7c7830a976be168cee6eeb738d4feda
ToppCell	SMG-Goblet\|World / shred by cell class for bronchial biopsy	ACSL3 SLC35A3 DNAJC10 FAM3D	4.11e-04	187	83	4	5178118bdec91495253c88f58fd908cf831de7ef
ToppCell	21-Trachea-Epithelial-Intermediate_ciliated\|Trachea / Age, Tissue, Lineage and Cell class	PPIL6 DNAH7 RSPH9 PTPRT	4.11e-04	187	83	4	1a2178a195d078d1963947b327c6d0d4f2f48341
Computational	Metal / Ca ion binding.	ACSL3 DSG1 DSG3 LRP1 DGKA PFKP	6.26e-05	133	56	6	MODULE_324
Drug	calystegine C1	KLHDC3 TREH GBA2	1.62e-06	7	83	3	CID000385737
Drug	LB-2	TREH LAMA1 CPT1B GBA2	3.14e-06	28	83	4	CID000129887
Drug	2-amino-4-methoxy-3-butenoic acid	MAT1A MAT2A GOT2	1.00e-05	12	83	3	CID004472505
Drug	2-amino-4-methylthio-3-butenoic acid	MAT1A MAT2A	1.31e-05	2	83	2	ctd:C083253
Drug	chikusetsusaponin V	STK11 PRPH2 GOT2	1.65e-05	14	83	3	CID000160238
Drug	calystegine B2	KLHDC3 TREH GBA2	1.65e-05	14	83	3	CID000124434
Disease	Malignant neoplasm of lung	ATG101 STK11 SND1 WNT5A FGF9 PTPRT	9.35e-05	266	81	6	C0242379
Disease	Common Migraine	LRP1 TRPM8	1.55e-04	7	81	2	C0338480
Disease	Abdominal Migraine	LRP1 TRPM8	2.65e-04	9	81	2	C0270858
Disease	Sick Headaches	LRP1 TRPM8	2.65e-04	9	81	2	C0700438
Disease	Acute Confusional Migraine	LRP1 TRPM8	2.65e-04	9	81	2	C0521664
Disease	Status Migrainosus	LRP1 TRPM8	2.65e-04	9	81	2	C0338489
Disease	Cervical Migraine Syndrome	LRP1 TRPM8	2.65e-04	9	81	2	C0007852
Disease	Hemicrania migraine	LRP1 TRPM8	2.65e-04	9	81	2	C0018984
Disease	Migraine Disorders	LRP1 TRPM8	5.69e-04	13	81	2	C0149931
Disease	Headache	NUFIP2 LRP1 TRPM8	7.36e-04	64	81	3	HP_0002315
Disease	Anilide use measurement	LRP1 TRPM8	7.64e-04	15	81	2	EFO_0009938
Disease	lipid metabolism disorder (implicated_via_orthology)	MAT1A MAT2A	7.64e-04	15	81	2	DOID:3146 (implicated_via_orthology)
Disease	Lung Neoplasms	ATG101 STK11 SND1 WNT5A FGF9	8.27e-04	265	81	5	C0024121
Disease	Narcolepsy-Cataplexy Syndrome	CPT1B CTSH	8.71e-04	16	81	2	C0751362
Disease	migraine without aura, susceptibility to, 4	LRP1 TRPM8	8.71e-04	16	81	2	MONDO_0011847
Disease	Narcolepsy	CPT1B CTSH	9.85e-04	17	81	2	C0027404
Disease	Antimigraine preparation use measurement	LRP1 TRPM8	1.51e-03	21	81	2	EFO_0009939
Disease	migraine disorder, Headache	NUFIP2 LRP1 TRPM8	1.73e-03	86	81	3	HP_0002315, MONDO_0005277
Disease	S-warfarin to R-warfarin ratio measurement	ARFGEF3 CTR9 ADGRL3	2.30e-03	95	81	3	EFO_0803331
Disease	Alzheimer disease, age at onset	COL12A1 OTOGL LAMA1 LARS1 HERC2	2.57e-03	343	81	5	EFO_0004847, MONDO_0004975

Protein segments in the cluster

Peptide	Gene	Start	Entry
EEYSKDTSKGMGGYY	EOMES	666	O95936
NLRGKSGQGYYVEMT	BACE1	66	P56817
TERGGKIYYDGMGQD	DISP3	346	Q9P2K9
GYMAQSTQYEKCGGG	AKAP4	576	Q5JQC9
MYSGMFRNGLEDGYG	ALS2	1071	Q96Q42
DSGLYLGMNEKGELY	FGF9	111	P31371
GDAEDVYYKSMPNLG	ADGRL3	1386	Q9HAR2
GLYVYGDVGTGKTMV	AFG1L	131	Q8WV93
TKRTGYESGEYEMLG	DCTN2	76	Q13561
VLGEPQGYGVMEYKA	MORN1	91	Q5T089
SNVKYVMGRNDGGYL	DSG3	421	P32926
VFGGMVEYGKYSNDL	HCFC1	96	P51610
GAVLGQKAFDMYSGD	FAM3D	111	Q96BQ1
GDDGYLYIFTGDGGM	HHIPL1	321	Q96JK4
MKDDLADYGGYDGGY	EIF3J	236	O75822
GVGDYKLGNDFMGIT	GLOD4	91	Q9HC38
GSTNSYRMGKEGKYD	HERC2	1911	O95714
VEIGNPTYKMYEGGE	LRP1	4466	Q07954
GAGDQGLMFGYATDE	MAT2A	131	P31153
MEGLAGYVYKAASEG	FEM1B	1	Q9UK73
YEGYQGMVDGGSNIA	PFKP	61	Q01813
DGEMAKYVQGDAIGY	DGKA	36	P23743
GAGDQGLMFGYATDE	MAT1A	131	Q00266
DIVYGKGDNGESIYG	PPIL6	211	Q8IXY8
DYEMKVCAYGAQGEG	ITGB4	1191	P16144
DVGLAMGKLYGNDFS	POU2F3	211	Q9UKI9
GVYTNEYGGREMQDL	DSG1	631	Q02413
MKRGQGYGFKEEYEA	PTPRT	881	O14522
MYQYQVLAEAGGELG	PAPPA2	1086	Q9BXP8
MEKYENLGLVGEGSY	CDKL2	1	Q92772
GGDGLGQMSLEFYQK	ATG101	91	Q9BSB4
GGRNDQGKRYYHGME	GRHL3	81	Q8TE85
PYKGGNTMTGDAIDY	COL12A1	211	Q99715
GQLMVSYEGKAMGYQ	GBA2	66	Q9HCG7
GQGDFYYGNLMVGGT	GLT6D1	221	Q7Z4J2
EYLVGDYSMGKGQAP	ARFGEF3	1316	Q5TH69
MAALLKFADDQGYGG	DNAH7	3441	Q8WXX0
ADLQYGYGGVDMNEP	CUL2	121	Q13617
GLGQMYIYRGDKENA	CTR9	346	Q6PD62
MAGAIAGAYYGMDQV	ADPRS	321	Q9NX46
MYQGEFGLNMKLGYG	ANKMY1	1	Q9P2S6
NKGIMGEDTYPYQGK	CTSH	196	P09668
LGKIMYIFGGYEQQA	KLHDC3	136	Q9BQ90
YDKYGEKGLEDNQGG	DNAJC10	96	Q8IXB1
LDGYMYIFTGDGGQA	HHIPL2	346	Q6UWX4
QQYLSGGMCGYDLDG	SEC14L2	81	O76054
SMYDLDGNGYISKAE	NCALD	106	P61601
ADDGYGVSYMIAGEN	CPT1B	716	Q92523
EGLGEGPYMLASYGQ	OTOGL	1211	Q3ZCN5
YLGLDYMSKQNGGEG	HPGD	116	P15428
GLYLGMNDKGELYGS	FGF20	116	Q9NP95
AGKYLYVYGDMDEDG	RIMBP2	196	O15034
KNYGYVYVGTGEKNM	RSPH9	256	Q9H1X1
GKGESAGYMEPYEAQ	SHB	261	Q15464
YGILKGYVQGEADIM	SLC9C1	746	Q4G0N8
KLGGLDYMYSAQGNG	SCYL1	156	Q96KG9
GFYEGIMLVDGFKGQ	LARS1	471	Q9P2J5
AYGQTGAGKTYTMEG	KIFC3	526	Q9BVG8
QGDQLMAYGGKLKYS	LAMA1	1226	P25391
GMEGDRQYGDGYLLQ	SIGLEC8	16	Q9NYZ4
GREYGMIYLGKDTNG	SND1	106	Q7KZF4
NEQGAFYGGMAGFVL	SLC5A3	466	P53794
IGKYLMGDLLGEGSY	STK11	46	Q15831
EEMFGGGAADDYGKA	PRR12	951	Q9ULL5
DVMGGLDGDMFNYYK	PI4KB	716	Q9UBF8
GDGYYLAMGGAVAQH	SARDH	641	Q9UL12
SYAKNMGLYGERVGA	GOT2	276	P00505
GGQSVTMGYYKNEAK	ACSL3	531	O95573
GPDAVDGVMNGEYYQ	CLTA	71	P09496
DGVMNGEYYQESNGP	CLTA	76	P09496
GYITNGYMGKGADND	NUFIP2	196	Q7Z417
DPEKIGDGMNAYVAY	SNX1	151	Q13596
GQGLKNGMKYYRDTD	PRPH2	131	P23942
IMVGTGNGLAKVYYD	WDR70	486	Q9NW82
AMYEKYDVSNGGQPG	TREH	511	O43280
YQDHMQYIGEGAKTG	WNT5A	86	P41221
CGLGGVYQQMGEYDT	TTC28	1001	Q96AY4
MGVYIYDGELVSKNG	SLC35A3	221	Q9Y2D2
YGYILCKMGGNSDIG	TVP23A	166	A6NH52
TGGTHYGLMKYIGEV	TRPM8	181	Q7Z2W7
QKGDEAGGYVKVYTG	STAC3	336	Q96MF2
GRGDMKYGIYAVENE	VTI1B	106	Q9UEU0
YEGSPQGYAEASMEK	TNS2	626	Q63HR2
EGITVYSMQFGGYAK	HEBP1	126	Q9NRV9