Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 OR13C9 OR13C2 OR10AC1 OR6Y1 OR56B4	3.10e-05	431	112	11	GO:0004984
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 OR13C9 OR13C2 OR10AC1 OR6Y1 OR56B4	1.82e-05	432	109	11	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR6B1 OR13C5 CALHM1 OR13C3 OR13C4 OR13F1 OR6M1 OR13C9 OR13C2 OR10AC1 OR6Y1 OR56B4	3.25e-05	547	109	12	GO:0007606
GeneOntologyBiologicalProcess	sensory perception of smell	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 OR13C9 OR13C2 OR10AC1 OR6Y1 OR56B4	3.58e-05	465	109	11	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 OR13C9 OR13C2 OR10AC1 OR6Y1 OR56B4	5.23e-05	485	109	11	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 OR13C9 OR13C2 OR10AC1 PCDH15 OR6Y1 OR56B4	5.91e-05	582	109	12	GO:0050906
GeneOntologyBiologicalProcess	positive regulation of sodium ion transport	ACTN4 ADRB2 CNKSR3 PLCB1	7.08e-05	42	109	4	GO:0010765
GeneOntologyBiologicalProcess	positive regulation of sodium ion transmembrane transporter activity	ACTN4 CNKSR3 PLCB1	7.65e-05	16	109	3	GO:2000651
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 OR13C9 OR13C2 OR10AC1 OR6Y1 OR56B4	1.04e-04	524	109	11	GO:0009593
GeneOntologyBiologicalProcess	phosphatidylinositol catabolic process	PLCB1 PLCG1	1.65e-04	4	109	2	GO:0031161
GeneOntologyBiologicalProcess	positive regulation of sodium ion transmembrane transport	ACTN4 CNKSR3 PLCB1	2.05e-04	22	109	3	GO:1902307
Domain	Pellino	PELI3 PELI1	1.03e-04	3	110	2	PF04710
Domain	Pellino_fam	PELI3 PELI1	1.03e-04	3	110	2	IPR006800
Domain	Olfact_rcpt	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 OR13C9 OR13C2 OR6Y1 OR56B4	1.10e-04	393	110	10	IPR000725
Domain	PET	PRICKLE1 LMCD1	5.08e-04	6	110	2	PF06297
Domain	PET_domain	PRICKLE1 LMCD1	5.08e-04	6	110	2	IPR010442
Domain	PET	PRICKLE1 LMCD1	5.08e-04	6	110	2	PS51303
Domain	GPCR_Rhodpsn_7TM	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 ADRB2 OR13C9 OR13C2 OR6Y1 OR56B4	1.99e-03	670	110	11	IPR017452
Domain	7tm_1	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 ADRB2 OR13C9 OR13C2 OR6Y1 OR56B4	2.16e-03	677	110	11	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 ADRB2 OR13C9 OR13C2 OR6Y1 OR56B4	2.36e-03	685	110	11	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 ADRB2 OR13C9 OR13C2 OR6Y1 OR56B4	2.53e-03	691	110	11	PS50262
Domain	GPCR_Rhodpsn	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 ADRB2 OR13C9 OR13C2 OR6Y1 OR56B4	2.56e-03	692	110	11	IPR000276
Domain	IRS	IRS4 TLN1	2.99e-03	14	110	2	PF02174
Domain	IRS_PTB	IRS4 TLN1	2.99e-03	14	110	2	IPR002404
Domain	EF-hand_like	PLCB1 PLCG1	3.43e-03	15	110	2	PF09279
Domain	PI-PLC-Y	PLCB1 PLCG1	3.43e-03	15	110	2	PF00387
Domain	PLCYc	PLCB1 PLCG1	3.43e-03	15	110	2	SM00149
Domain	PLipase_C_Pinositol-sp_Y	PLCB1 PLCG1	3.43e-03	15	110	2	IPR001711
Domain	PIPLC_Y_DOMAIN	PLCB1 PLCG1	3.43e-03	15	110	2	PS50008
Domain	PI-PLC_fam	PLCB1 PLCG1	3.43e-03	15	110	2	IPR001192
Domain	PLC_EF-hand-like	PLCB1 PLCG1	3.43e-03	15	110	2	IPR015359
Domain	Znf_CCCH	DUS3L ZC3H10 ZC3H12C	4.85e-03	58	110	3	IPR000571
Domain	ZF_C3H1	DUS3L ZC3H10 ZC3H12C	4.85e-03	58	110	3	PS50103
Domain	PI-PLC-X	PLCB1 PLCG1	4.95e-03	18	110	2	PF00388
Domain	PLCXc	PLCB1 PLCG1	4.95e-03	18	110	2	SM00148
Domain	Zn_pept	CPB2 AGBL4	4.95e-03	18	110	2	SM00631
Domain	Fd_Rdtase_FAD-bd	NDOR1 NOX1	5.51e-03	19	110	2	IPR017927
Domain	FAD_FR	NDOR1 NOX1	5.51e-03	19	110	2	PS51384
Domain	PIPLC_X_DOMAIN	PLCB1 PLCG1	5.51e-03	19	110	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCB1 PLCG1	5.51e-03	19	110	2	IPR000909
Domain	CARBOXYPEPT_ZN_2	CPB2 AGBL4	5.51e-03	19	110	2	PS00133
Domain	Riboflavin_synthase-like_b-brl	NDOR1 NOX1	5.51e-03	19	110	2	IPR017938
Pathway	REACTOME_SENSORY_PERCEPTION	OR6B1 OR13C5 CALHM1 OR13C3 OR13C4 OR13F1 OR6M1 OR13C9 OR13C2 OR10AC1 PCDH15 OR6Y1 OR56B4 OTOG	5.49e-06	636	75	14	M41834
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 OR13C9 OR13C2 OR10AC1 OR6Y1 OR56B4	1.19e-05	417	75	11	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 OR13C9 OR13C2 OR6Y1 OR56B4	3.82e-05	389	75	10	M14091
Pathway	WP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY	OCRL FIG4 PLCB1 PLCG1	1.02e-04	46	75	4	M48317
Pubmed	Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.	OR13C5 OR13C3 OR13C4 OR13C9 OR13C2	2.46e-10	12	112	5	12906860
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PITRM1 ZNF507 STOX2 NUP155 EHMT1 PLCB1 BOP1 HERC4 NBR1 MED13 ZMYM4	1.20e-06	529	112	11	14621295
Pubmed	The human olfactory receptor gene family.	OR6B1 OR13C5 OR13C3 OR13C4 OR13F1 OR6M1 OR13C9 OR13C2 OR10AC1 OR6Y1 OR56B4	1.49e-06	541	112	11	14983052
Pubmed	RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State.	RABL2B RABL2A	1.03e-05	2	112	2	27732084
Pubmed	Ins(1,4,5)P(3) regulates phospholipase Cbeta1 expression in cardiomyocytes.	ITPR2 PLCB1	1.03e-05	2	112	2	18692062
Pubmed	Analysis of relative gene dosage and expression differences of the paralogs RABL2A and RABL2B by Pyrosequencing.	RABL2B RABL2A	1.03e-05	2	112	2	20138207
Pubmed	Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13.	RABL2B RABL2A	1.03e-05	2	112	2	10444334
Pubmed	Variants in RABL2A causing male infertility and ciliopathy.	RABL2B RABL2A	1.03e-05	2	112	2	33075816
Pubmed	RABL2 positively controls localization of GPCRs in mammalian primary cilia.	RABL2B RABL2A	1.03e-05	2	112	2	30578315
Pubmed	Analyses of shared genetic factors between asthma and obesity in children.	ETV5 ADRB2 PTPRD KCTD15	1.63e-05	47	112	4	20816195
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	IRS4 PITRM1 POLE ANGEL1 RANBP6 OCRL SSRP1 TRUB2 ITPR2 MRPL2 VPS13D NUP155 MAVS PTAR1 BOP1 NBR1	2.45e-05	1496	112	16	32877691
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	KRI1 AGBL4 ZC3H10 PTPRD FIG4 PCDH15 PLCB1	2.53e-05	265	112	7	19240061
Pubmed	Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle gene.	PRICKLE1 LMCD1	3.08e-05	3	112	2	14516664
Pubmed	Phospholipase C in mouse oocytes: characterization of beta and gamma isoforms and their possible involvement in sperm-induced Ca2+ spiking.	PLCB1 PLCG1	3.08e-05	3	112	2	8687404
Pubmed	Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4.	ACTN4 ADRB2	3.08e-05	3	112	2	28569760
Pubmed	Paraoxonase 2 (PON2) decreases high glucose-induced macrophage triglycerides (TG) accumulation, via inhibition of NADPH-oxidase and DGAT1 activity: studies in PON2-deficient mice.	NOX1 DGAT1	3.08e-05	3	112	2	19748094
Pubmed	Differential modulation of Helicobacter pylori lipopolysaccharide-mediated TLR2 signaling by individual Pellino proteins.	PELI3 PELI1	3.08e-05	3	112	2	27302665
Pubmed	Primary phospholipase C and brain disorders.	PLCB1 PLCG1	3.08e-05	3	112	2	26639088
Pubmed	Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCγ1 axis.	PTPRD PLCG1	3.08e-05	3	112	2	35848503
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	ANGEL1 STK11IP ITPR2 VPS13D NUP155 MAVS FIG4 VPS41 DOP1B	3.85e-05	504	112	9	34432599
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	SRP19 PELI1 DUS3L MAVS HAPLN3 HERC4 NBR1	5.78e-05	302	112	7	30561431
Pubmed	Nuclear PLCs affect insulin secretion by targeting PPARγ in pancreatic β cells.	PLCB1 PLCG1	6.14e-05	4	112	2	21974932
Pubmed	Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.	ITPR2 PLCB1	6.14e-05	4	112	2	17925404
Pubmed	Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases.	PELI3 PELI1	6.14e-05	4	112	2	16884718
Pubmed	Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1.	PELI3 PELI1	6.14e-05	4	112	2	19081057
Pubmed	Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways.	IRS4 PLCG1	6.14e-05	4	112	2	18165436
Pubmed	Molecular cloning and characterization of a novel phospholipase C, PLC-eta.	PLCB1 PLCG1	6.14e-05	4	112	2	15702972
Pubmed	Genome-wide ENU mutagenesis to reveal immune regulators.	RABL2B RABL2A	6.14e-05	4	112	2	11567631
Pubmed	Structural dynamics of alpha-actinin-vinculin interactions.	ACTN4 TLN1	6.14e-05	4	112	2	15988023
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	ITPR2 PLCB1 PLCG1	6.26e-05	24	112	3	10843712
Pubmed	Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling.	RABL2B RABL2A	1.02e-04	5	112	2	33241915
Pubmed	The TRPM7 channel is inactivated by PIP(2) hydrolysis.	PLCB1 PLCG1	1.02e-04	5	112	2	11941371
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	IRS4 EPPK1 ORC3 POLE SSRP1 JAK1 NUP155 UBP1 EHMT1	1.17e-04	583	112	9	29844126
Pubmed	Genome-wide meta-analysis identifies new susceptibility loci for migraine.	ACTN4 PTPRD LEPROTL1 ASTN2	1.21e-04	78	112	4	23793025
Pubmed	The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation.	MAVS NBR1	1.53e-04	6	112	2	33577621
Pubmed	Expression and immunohistochemical localization of eight phospholipase C isoforms in adult male mouse cerebellar cortex.	PLCB1 PLCG1	1.53e-04	6	112	2	8739298
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR2 PLCG1	1.53e-04	6	112	2	21762810
Pubmed	Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases.	PELI3 PELI1	1.53e-04	6	112	2	17675297
Pubmed	The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities.	PELI3 PELI1	1.53e-04	6	112	2	25027698
Pubmed	Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1.	JAK1 PLCG1	1.53e-04	6	112	2	14978237
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	DPY19L3 SELENBP1 PITRM1 LMCD1 RANBP6 STK11IP P3H4 JAK1 MAVS VPS41 MMP15 NBR1	1.64e-04	1061	112	12	33845483
Pubmed	Functional significance of isoform diversification in the protocadherin gamma gene cluster.	SLC27A6 PCDHGB5 PCDHGB4	1.81e-04	34	112	3	22884324
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	IRS4 PITRM1 POLE KRI1 DARS1 ACTN4 SSRP1 NUP155 STARD9 TLN1 EHMT1 BOP1 PLCG1 NBR1	1.99e-04	1425	112	14	30948266
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	ORC3 KRI1 DARS1 LCP1 NUP155 TLN1 BOP1	2.03e-04	370	112	7	22922362
Pubmed	DNA sequence and analysis of human chromosome 9.	OR13C5 OR13C3 OR13C4 OR13F1 RANBP6 TRUB2 OR13C2	2.03e-04	370	112	7	15164053
Pubmed	A quantitative protein interaction network for the ErbB receptors using protein microarrays.	IRS4 JAK1 TLN1 PLCG1	2.10e-04	90	112	4	16273093
Pubmed	Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.	PRICKLE1 LMCD1	2.14e-04	7	112	2	17937400
Pubmed	Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo.	PLCB1 PLCG1	2.14e-04	7	112	2	17634444
Pubmed	The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice.	NDOR1 ADRB2	2.14e-04	7	112	2	36243005
Pubmed	Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development.	NDOR1 MAVS	2.14e-04	7	112	2	26588779
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ORC3 ZNF507 ETV5 SRP19 DARS1 ACTN4 SSRP1 LCP1 ZC3H10 TLN1 EHMT1 ZMYM4	2.34e-04	1103	112	12	34189442
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IRS4 EPPK1 POLE KRI1 ACTN4 LCP1 NUP155 TLN1 BOP1	2.71e-04	653	112	9	22586326
Pubmed	Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.	ETV5 KCTD15	2.84e-04	8	112	2	20520848
Pubmed	Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner.	PELI3 PELI1	2.84e-04	8	112	2	15917247
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	PITRM1 POLE KRI1 RANBP6 ACTN4 LCP1 TBCCD1 PTPRD NUP155 BOP1 PLCG1	3.15e-04	974	112	11	28675297
Pubmed	Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.	SPATA8 PITRM1 PTPRD	3.17e-04	41	112	3	18951430
Pubmed	Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.	PLCB1 PLCG1	3.65e-04	9	112	2	7589147
Pubmed	Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.	PLCB1 PLCG1	3.65e-04	9	112	2	10501179
Pubmed	EphB6-null mutation results in compromised T cell function.	EFNB3 PLCG1	3.65e-04	9	112	2	15599401
Pubmed	Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?	ETV5 KCTD15	4.55e-04	10	112	2	19746409
Pubmed	Expression of phospholipase C isozymes by murine B lymphocytes.	PLCB1 PLCG1	4.55e-04	10	112	2	2033248
Pubmed	Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference.	ETV5 KCTD15	4.55e-04	10	112	2	19692490
Pubmed	Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.	RABL2B RABL2A PTPRD	4.75e-04	47	112	3	15172686
Pubmed	Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae.	ABCA13 TBCCD1 MMP15	5.38e-04	49	112	3	31609468
Pubmed	Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.	ETV5 KCTD15	5.55e-04	11	112	2	19812171
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	PCDH15 OTOG	5.55e-04	11	112	2	31776257
Pubmed	VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation.	MAVS NBR1	5.55e-04	11	112	2	37352355
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	IRS4 EPPK1 ABCA13 TLN1 OTOG	5.82e-04	208	112	5	33230847
Pubmed	Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.	MLH3 VPS41	6.64e-04	12	112	2	7596406
Pubmed	The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.	RABL2B RABL2A	6.64e-04	12	112	2	28625565
Pubmed	The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.	KCTD7 SPATA8	7.83e-04	13	112	2	25293881
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	POLE ANGEL1 RANBP6 STK11IP PARP4 VPS13D NUP155 CNKSR3	7.90e-04	606	112	8	36538041
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	EPPK1 DARS1 ACTN4 SSRP1 LCP1 NUP155 TLN1 PLCG1	7.98e-04	607	112	8	39147351
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	RALGAPB TLN1 EHMT1 PLCB1 DOP1B	8.29e-04	225	112	5	12168954
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR6B1 OR13C3 OR13F1 OR10AC1 OR6Y1 OR56B4	8.38e-04	340	112	6	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR6B1 OR13C3 OR13F1 OR10AC1 OR6Y1 OR56B4	8.77e-04	343	112	6	32295537
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	PITRM1 DARS1 ACTN4 LCP1 TLN1 PLCG1	8.90e-04	344	112	6	30333137
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NDOR1 EPPK1 POLE STK11IP ITPR2 SLC2A4RG TLN1 EHMT1 KCTD15 PLCG1 MED13	8.94e-04	1105	112	11	35748872
Pubmed	Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.	ETV5 KCTD15	9.12e-04	14	112	2	19851340
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR6B1 OR13C3 OR13F1 OR10AC1 OR6Y1 OR56B4	9.17e-04	346	112	6	14611657
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	IRS4 PITRM1 DARS1 ACTN4 SSRP1 NUP155 TLN1	9.99e-04	484	112	7	31995728
Pubmed	Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice.	JAK1 PLCG1	1.05e-03	15	112	2	17114464
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGB5 PCDHGB4	1.05e-03	15	112	2	23515096
Pubmed	Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.	ITPR2 PLCB1	1.05e-03	15	112	2	28578927
Pubmed	Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.	ETV5 KCTD15	1.05e-03	15	112	2	20215397
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	OCRL LCP1 ITPR2 MAVS	1.09e-03	139	112	4	25476789
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	WDR64 PRICKLE1 ORC3 POLE PARP4 UBP1 EHMT1 PLCB1	1.10e-03	638	112	8	31182584
Pubmed	Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.	ETV5 KCTD15	1.20e-03	16	112	2	20724581
Pubmed	Rapid and Integrative Discovery of Retina Regulatory Molecules.	KCTD7 ABCA13	1.20e-03	16	112	2	30157441
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	SPATA8 ORC3 TRUB2 PARP4 UBXN11 PTPRD KCTD15 ADAMTS20 ASTN2	1.30e-03	814	112	9	23251661
Pubmed	Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors.	RABL2B RABL2A	1.35e-03	17	112	2	30838872
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	EPPK1 ORC3 ITPR2 ZMYM4	1.44e-03	150	112	4	30154076
Pubmed	DNA replication in eukaryotic cells.	ORC3 POLE	1.52e-03	18	112	2	12045100
Pubmed	Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.	PLCB1 PLCG1	1.52e-03	18	112	2	1979339
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	LCP1 TLN1	1.52e-03	18	112	2	12119179
Pubmed	Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.	ETV5 PARP4	1.52e-03	18	112	2	25117710
Pubmed	Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.	ABCA13 GCNT7	1.70e-03	19	112	2	25367360
Pubmed	Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.	XIRP1 PLCB1	1.70e-03	19	112	2	24564958
Pubmed	Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate.	ETV5 EHMT1	1.70e-03	19	112	2	34150743
Pubmed	BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites.	DARS1 ACTN4 SSRP1	1.72e-03	73	112	3	32347575
Cytoband	9q31.1	OR13C5 OR13C3 OR13C4 OR13F1 OR13C9 OR13C2	7.72e-10	41	112	6	9q31.1
Cytoband	Ensembl 112 genes in cytogenetic band chr9q31	OR13C5 OR13C3 OR13C4 OR13F1 OR13C9 OR13C2	1.17e-06	137	112	6	chr9q31
Cytoband	19q13.11	DPY19L3 ZNF507 KCTD15	1.86e-04	45	112	3	19q13.11
Cytoband	14q24.3	ANGEL1 ISM2 MLH3	1.56e-03	93	112	3	14q24.3
Cytoband	8q24.3	EPPK1 BOP1 DGAT1	2.72e-03	113	112	3	8q24.3
GeneFamily	Olfactory receptors, family 13	OR13C5 OR13C3 OR13C4 OR13F1 OR13C9 OR13C2	2.59e-10	23	70	6	162
GeneFamily	Pellino E3 ubiquitin protein ligases	PELI3 PELI1	4.42e-05	3	70	2	676
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLA2G4D PLCB1 PLCG1	5.15e-05	19	70	3	832
GeneFamily	RAB like GTPases	RABL2B RABL2A	1.47e-04	5	70	2	394
GeneFamily	Phospholipases	PLA2G4D PLCB1 PLCG1	5.73e-04	42	70	3	467
GeneFamily	Olfactory receptors, family 6	OR6B1 OR6M1 OR6Y1	1.01e-03	51	70	3	153
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KCTD7 POLE CYTL1 ISM2 P3H4 UBXN11	3.35e-06	161	112	6	9703b7e67d9fadb6129cad166bd01be915042e44
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ABCA13 CNNM1 STOX2 PTPRD CNKSR3 ASTN2	6.98e-06	183	112	6	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	ABCA13 CNNM1 STOX2 PTPRD CNKSR3 ASTN2	7.20e-06	184	112	6	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA13 PARP4 STOX2 VPS41 PLCB1 ASTN2	8.91e-06	191	112	6	d0e9afe7b6334dd515d3e68892efdc76347a55e5
Disease	response to anti-tuberculosis drug, drug-induced liver injury	PTPRD ASTN2	3.97e-05	3	108	2	EFO_0004228, EFO_0007918
Disease	metastasis measurement, disease progression measurement	ADRB2 HAPLN3 ASTN2	2.63e-04	34	108	3	EFO_0007675, EFO_0008336
Disease	endometrial cancer (is_implicated_in)	POLE JAK1 MLH3	3.12e-04	36	108	3	DOID:1380 (is_implicated_in)
Disease	unipolar depression	SELENBP1 ABCA13 ETV5 ITPR2 AGBL4 PTPRD LINGO1 FIG4 VPS41 KCTD15 ASTN2 PLCG1 ZMYM4	4.69e-04	1206	108	13	EFO_0003761
Disease	middle temporal gyrus volume measurement	OR13C3 OR13C4	7.14e-04	11	108	2	EFO_0010316
Disease	MAP kinase-activated protein kinase 3 measurement	CPB2 LCP1	1.01e-03	13	108	2	EFO_0008226
Disease	colorectal cancer (is_implicated_in)	POLE PELI1 JAK1 MLH3	1.04e-03	121	108	4	DOID:9256 (is_implicated_in)
Disease	smoking behavior, body mass index	ETV5 AGBL4 KCTD15 ASTN2	1.10e-03	123	108	4	EFO_0004318, EFO_0004340
Disease	obesity (implicated_via_orthology)	ETV5 ITPR2 PLCB1 ADAMTS20 MED13	1.19e-03	215	108	5	DOID:9970 (implicated_via_orthology)
Disease	unipolar depression, mood disorder	DPY19L3 ZNF507 LINGO1 ASTN2	1.51e-03	134	108	4	EFO_0003761, EFO_0004247
Disease	esterified cholesterol measurement, high density lipoprotein cholesterol measurement	LCP1 PCIF1	2.18e-03	19	108	2	EFO_0004612, EFO_0008589
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGB5 PTPRD PCDHGB4	2.27e-03	71	108	3	EFO_0007878, EFO_0007979
Disease	endometriosis	AGBL4 PCDHGB4 PLCB1 KCTD15 ASTN2	2.38e-03	252	108	5	EFO_0001065
Disease	peak expiratory flow	CYTL1 ADRB2 LINGO1 FIG4 CNKSR3 ASTN2 MMP15	2.41e-03	498	108	7	EFO_0009718
Disease	exercise test	PTPRD ZC3H12C	2.42e-03	20	108	2	EFO_0004328
Disease	free cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	LCP1 PCIF1	2.66e-03	21	108	2	EFO_0022277
Disease	HbA1c measurement	DPY19L3 NDOR1 P3H4 LINGO1 FIG4 PLCB1 OR6Y1 DGAT1	3.42e-03	675	108	8	EFO_0004541
Disease	Attention deficit hyperactivity disorder	PTPRD MED13	3.48e-03	24	108	2	C1263846
Disease	short-term memory	PTPRD FIG4 PCDH15	3.54e-03	83	108	3	EFO_0004335
Disease	Colorectal Neoplasms	SELENBP1 ABCA13 POLE MLH3 PTPRD	3.57e-03	277	108	5	C0009404

Protein segments in the cluster

Peptide	Gene	Start	Entry
RDLQPFPTCQALVYR	BOP1	396	Q14137
FNPLIYCRSPDFRIA	ADRB2	321	P07550
ELRRELPPDQAEYCI	ACTN4	866	O43707
TVLRFQEPPRYRDIC	ABCA13	41	Q86UQ4
ELARLLARVPCPEIY	CALHM1	151	Q8IU99
PRFCEEIKRNLPPYV	DPY19L3	681	Q6ZPD9
FLCRYVPVGLLERLP	DUS3L	581	Q96G46
LCYELNFPRSPRIRK	DGAT1	261	O75907
ETVPYLFCRSEEVRP	ASTN2	1291	O75129
LHRLRPIVYQECPVV	ADAMTS20	1626	P59510
EKERFYESRCRPVTP	JAK1	801	P23458
IVFPVPNICEYLTRE	ITPR2	2161	Q14571
CPALCEQIRYRIPEE	PCDHGB4	26	Q9UN71
IQLREYSPFRCIPRT	LRCOL1	136	A6NCL2
YTELREFRPEIPCIV	RABL2A	116	Q9UBK7
YTELREFRPEIPCIV	RABL2B	116	Q9UNT1
IRAFEQQYSPIPRIE	NOX1	366	Q9Y5S8
TPLLCPLIYSLRNRE	OR10AC1	286	Q8NH08
DRYVAICNPLRYPII	OR13C4	121	Q8NGS5
PYECPLLNSLRFERS	KCTD7	201	Q96MP8
EILPYLPCLTARDQD	MAVS	26	Q7Z434
VILPCRYRYEPALVS	HAPLN3	66	Q96S86
PLPQVVCTYRDVRFE	LHB	71	P01229
FRDPLPSAELYVLCR	ASMTL	511	O95671
CYAFLQRLPVPALQE	DOP1B	1766	Q9Y3R5
PLVFQEVPYEDIRLR	MMP15	176	P51511
PRERLDIYQPTARFC	ISM2	461	Q6H9L7
ACLPLPGYRVREITE	LCP1	41	P13796
QYRCQPFRSDLVLPF	MLH3	1096	Q9UHC1
VEALRFYLTLPECPL	HERC4	501	Q5GLZ8
PIPYCIARRLVDDTD	LEPROTL1	46	O95214
IDDLPCRFKYRTVVP	KRI1	516	Q8N9T8
PDVLLPNYFTCRRAR	LINGO1	411	Q96FE5
PRLYFDDTCVVPERL	ETV5	331	P41161
EAQFRDPCRSYVLPE	POLE	2141	Q07864
DRYVAICNPLRYPII	OR13C5	121	Q8NGS8
DRYVAICNPLRYPII	OR13C2	121	Q8NGS9
CPALCEQIRYRIPEE	PCDHGB5	26	Q9Y5G0
VRRTEGQYPSICPRL	PARP4	1676	Q9UKK3
SEPCVRYLPRLYLDI	CYTL1	51	Q9NRR1
FPTIVVTRLPYCRKE	OR6M1	156	Q8NGM8
LPIYDQDPSRCRGLL	LMCD1	161	Q9NZU5
ELFEYCNRPRRTILE	NDOR1	341	Q9UHB4
LRRSNYFRLPPCENV	MFAP5	151	Q13361
YFRLPPCENVDLQRP	MFAP5	156	Q13361
VRLYFSTCPFRQPLA	NUP155	366	O75694
CRPLRYPSIITESFV	OR56B2P	136	Q8NGI1
VDRYIAICRPLQYPS	OR56B4	126	Q8NH76
RPEQIQLYFACLPEE	PRICKLE1	41	Q96MT3
DCRPLTYQAAIPELR	PCDH15	276	Q96QU1
PLNIPRYEFGICVLD	KLHL28	316	Q9NXS3
EVEPRLVYCYPVRLA	PCIF1	396	Q9H4Z3
LPERYIKPTCREAFA	CPB2	396	Q96IY4
VICIFIFLYLRNPTP	GCNT7	16	Q6ZNI0
FFVNRPDSYCSILRP	FIG4	446	Q92562
YDLFIRPDTCNPRFR	AGBL4	66	Q5VU57
YAPVFEGEPLVLRCR	FCRLB	111	Q6BAA4
RLPDDYIILPTDLRC	RTL8C	131	O15255
YPQIGDRLDLLCPRA	EFNB3	51	Q15768
SRDIARGYERIPIPC	EHMT1	1011	Q9H9B1
DRYVAICNPLRYPII	OR13C3	151	Q8NGS6
IICERNPPFTARIYA	PELI1	141	Q96FA3
PLRTPRDEAIYECVA	PTPRD	86	P23468
AFLSPVPYFEQCRRD	OTOG	726	Q6ZRI0
TELYCRARGLPFPRV	PLA2G4D	686	Q86XP0
VNFIDCLVREYLLPP	ORC3	556	Q9UBD5
LIPPRRVITLYQCFS	IRS4	141	O14654
DRYVAICNPLRYPII	OR13C9	121	Q8NGT0
DRYVAICNPLRYPVI	OR13F1	121	Q8NGS4
APILSLRFSYICPDR	STK11IP	611	Q8N1F8
EIGLIPCPEARYNRS	PTAR1	31	Q7Z6K3
NTLPCVFYEIDRELP	SPATA22	291	Q8NHS9
ARSPADQDRFICIYP	SRP19	6	P09132
DYIIILPECFDTSRP	NBR1	731	Q14596
ILCDRRPPYTARIYA	PELI3	191	Q8N2H9
LTYVQLLRRCVPDPD	EPPK1	2931	P58107
QLLRRCVPDPDTGLY	EPPK1	3466	P58107
LTYVQLLRRCVPDPD	EPPK1	3996	P58107
TLPEELRPYVPLFCS	PITRM1	606	Q5JRX3
GPREEIVYLPCIYRN	SELENBP1	21	Q13228
IDAYFQLCQDPRLIP	CCT8L2	396	Q96SF2
FQYPPSTRELFRLLC	SWSAP1	66	Q6NVH7
PFKFLEPTLRLEYCE	DARS1	336	P14868
PAYERFQLVACPQER	STARD9	2001	Q9P2P6
TALRSPDRPECIRLY	MED13	1746	Q9UHV7
PSLNPFIYCLRNREV	OR6B1	281	O95007
DRYVAICNPLRYPVI	OR6Y1	126	Q8NGX8
PFLLECARIRGPEYL	RANBP6	736	O60518
EALPEPVICYELYQR	OCRL	796	Q01968
QCLTPRGRYDIRIYP	SSRP1	206	Q08945
YKPTRFRLLCASPVE	ANGEL1	336	Q9UNK9
LCRYFSNERIPPIIE	CNKSR3	461	Q6P9H4
DCTPLLTVTRFYNRP	CNNM1	491	Q9NRU3
DRVYQGCLTPARLEP	SLC2A4RG	316	Q9NR83
FSEYVLCREERRPQP	KCTD15	256	Q96SI1
VRNIRCLTPTRSFYP	SOGA3	786	Q5TF21
YQEIAPSFQRLPCPR	SPATA8	16	Q6RVD6
YDACRIIRERIPEAP	TLN1	26	Q9Y490
IPAEREYDFCDPLTR	STOX2	391	Q9P2F5
LRRCKRTLPAFQVPY	P3H4	116	Q92791
LELSELVVYCRPVPF	PLCG1	951	P19174
PFEEKVIQVRYDPCR	MRPL2	121	Q5T653
YLDLLPCRPFDTVFI	RALGAPB	1151	Q86X10
REYCARPRLDIIQPL	VPS41	296	P49754
VYRVFLNNLCPRPEI	PLCB1	211	Q9NQ66
VRPRLTIYVCREQPS	UBP1	426	Q9NZI7
VEYIPNAERPYRCRL	ZNF507	631	Q8TCN5
RVFQLLPPCEFYVFI	TBCCD1	456	Q9NVR7
IYINLCNIFPPDLVR	ZC3H12C	841	Q9C0D7
IRCLYFAPPEFLLEV	TRUB2	211	O95900
EYSLAPPRGVECRLL	ZC3H10	226	Q96K80
VTFLPAYACPRFLRI	SLC27A6	546	Q9Y2P4
LCYERQRSELPIRPV	THEGL	356	P0DJG4
RQETSREYLCPPRVL	XIRP1	1646	Q702N8
NTDNPLRCPVRLYEF	ZMYM4	1461	Q5VZL5
PFYDPSTQRCLRDIL	UBXN11	251	Q5T124
TRDFILPCDVTEYPI	WDR64	916	B1ANS9
PCFGQSLPLVYLRTR	VPS13D	2846	Q5THJ4