Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	SUPT20HL1 TCERG1L SH2D3C IRAK2 POU2AF1 ATG2A CBFA2T3 AR ARID5A MAGI2 KMT2C WWC2 IGF2BP1 SMARCA4 IRS2 BRD1 HERPUD1 ZNF541	2.83e-05	1160	104	18	GO:0030674
GeneOntologyMolecularFunction	molecular adaptor activity	SUPT20HL1 TCERG1L SH2D3C IRAK2 POU2AF1 ATG2A CBFA2T3 AR ARID5A MAGI2 KMT2C WWC2 IGF2BP1 SMARCA4 IRS2 BRD1 HERPUD1 ZNF541 PCNT	6.63e-05	1356	104	19	GO:0060090
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	FOXD2 EVX1 POU4F2 GATA5 MLXIP AR FOXP4 HOXD1 GLI2 GLI3 ZNF516 NR2E1 SMARCA4 ZFHX2 SP5 EMX1 ELL FOXD1	9.26e-05	1271	104	18	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	FOXD2 DUX4L9 EVX1 POU4F2 GATA5 MLXIP AR FOXP4 HOXD1 GLI2 GLI3 ZNF516 NR2E1 SMARCA4 ZFHX2 SP5 LHX5 EMX1 FOXD1	1.73e-04	1459	104	19	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXD2 EVX1 POU4F2 GATA5 MLXIP AR FOXP4 HOXD1 GLI2 GLI3 ZNF516 NR2E1 SMARCA4 ZFHX2 SP5 EMX1 FOXD1	2.27e-04	1244	104	17	GO:0000978
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	FOXD2 DUX4L9 EVX1 POU4F2 GATA5 MLXIP AR FOXP4 HOXD1 GLI2 GLI3 ZNF516 NR2E1 ZFHX2 SP5 LHX5 EMX1 FOXD1	3.41e-04	1412	104	18	GO:0000981
GeneOntologyMolecularFunction	POU domain binding	POU2AF1 AR	5.55e-04	7	104	2	GO:0070974
GeneOntologyMolecularFunction	signaling adaptor activity	SH2D3C IRAK2 MAGI2 WWC2 IRS2	5.74e-04	129	104	5	GO:0035591
GeneOntologyMolecularFunction	nuclear androgen receptor binding	AR ARID5A SMARCA4	6.68e-04	33	104	3	GO:0050681
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	SETD1B KMT2C	7.37e-04	8	104	2	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	SETD1B KMT2C	1.18e-03	10	104	2	GO:0140999
GeneOntologyMolecularFunction	structural constituent of postsynaptic density	MAGI2 CTNND2	1.43e-03	11	104	2	GO:0098919
GeneOntologyBiologicalProcess	brain development	GAK TACC2 ATXN1L IGF2BP1 GLI2 GLI3 SEC24B NR2E1 SEC16A SMARCA4 LHX5 IRS2 ULK1 EMX1 PCNT	1.43e-05	859	99	15	GO:0007420
GeneOntologyBiologicalProcess	neural precursor cell proliferation	GAK TACC2 IGF2BP1 GLI3 NR2E1 LHX5 EMX1 PCNT	1.66e-05	233	99	8	GO:0061351
GeneOntologyBiologicalProcess	head development	GAK TACC2 ATXN1L IGF2BP1 GLI2 GLI3 SEC24B NR2E1 SEC16A SMARCA4 LHX5 IRS2 ULK1 EMX1 PCNT	3.14e-05	919	99	15	GO:0060322
GeneOntologyBiologicalProcess	cell proliferation in forebrain	TACC2 IGF2BP1 GLI3 LHX5	3.25e-05	38	99	4	GO:0021846
GeneOntologyBiologicalProcess	cell morphogenesis	WASF3 DACT2 EVX1 POU4F2 AR ARHGAP4 IGF2BP1 GLI2 GLI3 SEC24B NR2E1 SMARCA4 UNK ULK1 CTNND2 EMX1 FOXD1	4.99e-05	1194	99	17	GO:0000902
GeneOntologyBiologicalProcess	smoothened signaling pathway involved in ventral spinal cord interneuron specification	GLI2 GLI3	6.82e-05	3	99	2	GO:0021775
GeneOntologyBiologicalProcess	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	GLI2 GLI3	6.82e-05	3	99	2	GO:0021776
GeneOntologyBiologicalProcess	smoothened signaling pathway involved in ventral spinal cord patterning	GLI2 GLI3	6.82e-05	3	99	2	GO:0021910
GeneOntologyBiologicalProcess	cerebellar cortex morphogenesis	GLI2 LHX5 ULK1 PCNT	8.26e-05	48	99	4	GO:0021696
GeneOntologyBiologicalProcess	forebrain development	GAK TACC2 IGF2BP1 GLI2 GLI3 NR2E1 SMARCA4 LHX5 EMX1 PCNT	1.21e-04	489	99	10	GO:0030900
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	POU4F2 GATA5 CBFA2T3 ATXN1L AR ARID5A FAM220BP WWC2 FOXP4 ZNF469 GLI2 GLI3 NR2E1 SMARCA4 SP5	1.45e-04	1053	99	15	GO:0000122
GeneOntologyBiologicalProcess	central nervous system development	GAK WASF3 TACC2 ATXN1L IGF2BP1 GLI2 GLI3 SEC24B NR2E1 SEC16A SMARCA4 LHX5 IRS2 ULK1 EMX1 PCNT	1.77e-04	1197	99	16	GO:0007417
GeneOntologyBiologicalProcess	cerebellum morphogenesis	GLI2 LHX5 ULK1 PCNT	1.98e-04	60	99	4	GO:0021587
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	EVX1 POU4F2 ARHGAP4 IGF2BP1 GLI2 GLI3 SEC24B NR2E1 UNK ULK1 CTNND2 FOXD1	2.44e-04	748	99	12	GO:0048667
GeneOntologyBiologicalProcess	hindbrain morphogenesis	GLI2 LHX5 ULK1 PCNT	2.54e-04	64	99	4	GO:0021575
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	FOXD2 SUPT20HL1 POU2AF1 EVX1 POU4F2 GATA5 MLXIP AR ARID5A KMT2C CDK13 GLI2 GLI3 NR2E1 SMARCA4 ELL FOXD1	3.12e-04	1390	99	17	GO:0045944
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	POU4F2 GATA5 CBFA2T3 ATXN1L AR ARID5A FAM220BP WWC2 FOXP4 ZNF469 GLI2 GLI3 NR2E1 SMARCA4 SP5 ZNF541 FOXD1	3.36e-04	1399	99	17	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	POU4F2 GATA5 CBFA2T3 ATXN1L AR ARID5A FAM220BP WWC2 FOXP4 ZNF469 GLI2 GLI3 NR2E1 SMARCA4 SP5 ZNF541 FOXD1	3.77e-04	1413	99	17	GO:1902679
GeneOntologyBiologicalProcess	cerebellar cortex development	GLI2 LHX5 ULK1 PCNT	3.79e-04	71	99	4	GO:0021695
GeneOntologyCellularComponent	chromatin	FOXD2 SUPT20HL1 POLA1 BICRA EVX1 POU4F2 GATA5 MLXIP AR FOXP4 HOXD1 NR2E1 SMARCA4 ZFHX2 SP5 LHX5 BRD1 EMX1 ELL FOXD1	3.12e-05	1480	103	20	GO:0000785
GeneOntologyCellularComponent	GLI-SUFU complex	GLI2 GLI3	1.43e-04	4	103	2	GO:1990788
GeneOntologyCellularComponent	nuclear speck	SETD1B POU4F2 AR CDK13 GLI2 GLI3 BRD1 MNDA ELL	2.81e-04	431	103	9	GO:0016607
GeneOntologyCellularComponent	nuclear protein-containing complex	ELOA2 SETD1B POLA1 BICRA RANBP3 POLE2 POU2AF1 NUP214 MLXIP KMT2C POM121 CDK13 AGFG1 SMARCA4 BRD1 ELL ZNF541	3.88e-04	1377	103	17	GO:0140513
GeneOntologyCellularComponent	junctional membrane complex	RYR1 JPH3	8.46e-04	9	103	2	GO:0030314
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PITPNM2 FLNC SETD1B BICRA NUP214 ATG2A MLXIP STK11IP RYR1 KMT2C RPAP1 ZFP36L2 CDK13 ZNF516 SEC16A OGDHL UNKL ZFYVE26 IRS2 ULK1 ELL PCNT	2.20e-12	1105	106	22	35748872
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXD2 EVX1 POU4F2 GATA5 MLXIP AR FOXP4 HOXD1 ZFP36L2 GLI2 GLI3 NR2E1 ZFHX2 SP5 UNKL LHX5 EMX1 ZNF541	3.01e-10	908	106	18	19274049
Pubmed	Cilia-dependent GLI processing in neural crest cells is required for tongue development.	FOXD2 GLI2 GLI3 FOXD1	7.97e-08	14	106	4	28286175
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	BICRA RANBP3 NUP214 ATG2A ZNF469 POM121 GLI2 AGFG1 UNK PRRC1 PCNT	8.82e-08	430	106	11	35044719
Pubmed	Non-canonical activation of hedgehog in prostate cancer cells mediated by the interaction of transcriptionally active androgen receptor proteins with Gli3.	AR GLI2 GLI3	1.10e-07	4	106	3	29429990
Pubmed	BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression.	GLI2 GLI3 NR2E1	9.55e-07	7	106	3	19505455
Pubmed	Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks.	GLI2 GLI3 FOXD1	3.25e-06	10	106	3	33006313
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SETD1B NUP214 MLXIP KLHL29 MAGI2 RPAP1 SEC16A ULK1 PCNT	4.55e-06	407	106	9	12693553
Pubmed	Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.	POU4F2 GLI2 GLI3	5.93e-06	12	106	3	18417110
Pubmed	Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo.	EVX1 GLI2 GLI3	5.93e-06	12	106	3	21337666
Pubmed	Laforin and malin deletions in mice produce similar neurologic impairments.	NHLRC1 EPM2A	9.20e-06	2	106	2	22487859
Pubmed	Lafora Disease Is an Inherited Metabolic Cardiomyopathy.	NHLRC1 EPM2A	9.20e-06	2	106	2	28619201
Pubmed	Loss of malin, but not laforin, results in compromised autophagic flux and proteasomal dysfunction in cells exposed to heat shock.	NHLRC1 EPM2A	9.20e-06	2	106	2	27975203
Pubmed	The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein.	UNK UNKL	9.20e-06	2	106	2	1339381
Pubmed	Determinants of Gli2 co-activation of wildtype and naturally truncated androgen receptors.	AR GLI2	9.20e-06	2	106	2	25132524
Pubmed	Increased laforin and laforin binding to glycogen underlie Lafora body formation in malin-deficient Lafora disease.	NHLRC1 EPM2A	9.20e-06	2	106	2	22669944
Pubmed	Interdependence of laforin and malin proteins for their stability and functions could underlie the molecular basis of locus heterogeneity in Lafora disease.	NHLRC1 EPM2A	9.20e-06	2	106	2	26648032
Pubmed	GLI3 and androgen receptor are mutually dependent for their malignancy-promoting activity in ovarian and breast cancer cells.	AR GLI3	9.20e-06	2	106	2	35134468
Pubmed	A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome.	GLI2 GLI3	9.20e-06	2	106	2	17283082
Pubmed	Lafora progressive myoclonus epilepsy: NHLRC1 mutations affect glycogen metabolism.	NHLRC1 EPM2A	9.20e-06	2	106	2	21505799
Pubmed	Deciphering the role of malin in the lafora progressive myoclonus epilepsy.	NHLRC1 EPM2A	9.20e-06	2	106	2	22815132
Pubmed	Hyperphosphorylation of glucosyl C6 carbons and altered structure of glycogen in the neurodegenerative epilepsy Lafora disease.	NHLRC1 EPM2A	9.20e-06	2	106	2	23663739
Pubmed	New mouse models of congenital anorectal malformations.	GLI2 GLI3	9.20e-06	2	106	2	10693670
Pubmed	Progressive Myoclonus Epilepsy, Lafora Type	NHLRC1 EPM2A	9.20e-06	2	106	2	20301563
Pubmed	Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells.	AR GLI2	9.20e-06	2	106	2	20420697
Pubmed	Structural and Functional Brain Abnormalities in Mouse Models of Lafora Disease.	NHLRC1 EPM2A	9.20e-06	2	106	2	33092303
Pubmed	Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice.	RASGRF2 EMX1	9.20e-06	2	106	2	36645126
Pubmed	TACC2 is an androgen-responsive cell cycle regulator promoting androgen-mediated and castration-resistant growth of prostate cancer.	TACC2 AR	9.20e-06	2	106	2	22456197
Pubmed	Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin.	MAGI2 CTNND2	9.20e-06	2	106	2	10080919
Pubmed	Protein degradation and quality control in cells from laforin and malin knockout mice.	NHLRC1 EPM2A	9.20e-06	2	106	2	24914213
Pubmed	Lafora disease in the Indian population: EPM2A and NHLRC1 gene mutations and their impact on subcellular localization of laforin and malin.	NHLRC1 EPM2A	9.20e-06	2	106	2	18311786
Pubmed	Cortical sensory processing across motivational states during goal-directed behavior.	RASGRF2 EMX1	9.20e-06	2	106	2	36240769
Pubmed	Differential effects of GLI2 and GLI3 in regulating cervical cancer malignancy in vitro and in vivo.	GLI2 GLI3	9.20e-06	2	106	2	29967343
Pubmed	Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.	GLI2 GLI3	9.20e-06	2	106	2	20154143
Pubmed	Age-Related microRNA Overexpression in Lafora Disease Male Mice Provides Links between Neuroinflammation and Oxidative Stress.	NHLRC1 EPM2A	9.20e-06	2	106	2	36674605
Pubmed	Inflammation in Lafora Disease: Evolution with Disease Progression in Laforin and Malin Knock-out Mouse Models.	NHLRC1 EPM2A	9.20e-06	2	106	2	27041370
Pubmed	Impaired malin expression and interaction with partner proteins in Lafora disease.	NHLRC1 EPM2A	9.20e-06	2	106	2	38588813
Pubmed	Mild Lafora disease: clinical, neurophysiologic, and genetic findings.	NHLRC1 EPM2A	9.20e-06	2	106	2	25270369
Pubmed	Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment.	NHLRC1 EPM2A	9.20e-06	2	106	2	17337485
Pubmed	Four novel and two recurrent NHLRC1 (EPM2B) and EPM2A gene mutations leading to Lafora disease in six Turkish families.	NHLRC1 EPM2A	9.20e-06	2	106	2	22047982
Pubmed	Cyclin G-associated kinase: a novel androgen receptor-interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer.	GAK AR	9.20e-06	2	106	2	16161052
Pubmed	Normal exon copy number of the GLI2 and GLI3 genes in patients with esophageal atresia.	GLI2 GLI3	9.20e-06	2	106	2	23442119
Pubmed	Laforin-malin complex degrades polyglucosan bodies in concert with glycogen debranching enzyme and brain isoform glycogen phosphorylase.	NHLRC1 EPM2A	9.20e-06	2	106	2	24068615
Pubmed	Increased endoplasmic reticulum stress and decreased proteasomal function in lafora disease models lacking the phosphatase laforin.	NHLRC1 EPM2A	9.20e-06	2	106	2	19529779
Pubmed	Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease.	NHLRC1 EPM2A	9.20e-06	2	106	2	25416783
Pubmed	Increased oxidative stress and impaired antioxidant response in Lafora disease.	NHLRC1 EPM2A	9.20e-06	2	106	2	24838580
Pubmed	Novel mutations in EPM2A and NHLRC1 widen the spectrum of Lafora disease.	NHLRC1 EPM2A	9.20e-06	2	106	2	20738377
Pubmed	Dimerization of the glucan phosphatase laforin requires the participation of cysteine 329.	NHLRC1 EPM2A	9.20e-06	2	106	2	23922729
Pubmed	Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity.	NHLRC1 EPM2A	9.20e-06	2	106	2	22186021
Pubmed	Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy.	NHLRC1 EPM2A	9.20e-06	2	106	2	22186026
Pubmed	Sensitive quantification of α-glucans in mouse tissues, cell cultures, and human cerebrospinal fluid.	NHLRC1 EPM2A	9.20e-06	2	106	2	32817315
Pubmed	Astrocytes: new players in progressive myoclonus epilepsy of Lafora type.	NHLRC1 EPM2A	9.20e-06	2	106	2	29408991
Pubmed	Adult Gli2+/-;Gli3Δ699/+ Male and Female Mice Display a Spectrum of Genital Malformation.	GLI2 GLI3	9.20e-06	2	106	2	27814383
Pubmed	Dendritic spine abnormalities correlate with behavioral and cognitive deficits in mouse models of Lafora disease.	NHLRC1 EPM2A	9.20e-06	2	106	2	32785985
Pubmed	Modulation of functional properties of laforin phosphatase by alternative splicing reveals a novel mechanism for the EPM2A gene in Lafora progressive myoclonus epilepsy.	NHLRC1 EPM2A	9.20e-06	2	106	2	18617530
Pubmed	Lafora progressive myoclonus epilepsy: a meta-analysis of reported mutations in the first decade following the discovery of the EPM2A and NHLRC1 genes.	NHLRC1 EPM2A	9.20e-06	2	106	2	19267391
Pubmed	A study on etiology of incontinence in double knockout mouse model.	GLI2 GLI3	9.20e-06	2	106	2	36272934
Pubmed	Enhanced sensitivity of laforin- and malin-deficient mice to the convulsant agent pentylenetetrazole.	NHLRC1 EPM2A	9.20e-06	2	106	2	25309313
Pubmed	Gli activity is critical at multiple stages of embryonic mammary and nipple development.	AR GLI2 GLI3	9.77e-06	14	106	3	24260306
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SETD1B POLA1 BICRA RANBP3 NUP214 GATA5 KMT2C ZFP36L2 CDK13 GLI3 SEC16A UNKL BRD1 ELL PCNT	1.22e-05	1327	106	15	32694731
Pubmed	Interaction network of human early embryonic transcription factors.	BICRA NUP214 ATXN1L KMT2C FOXP4 ZNF516 SEC16A SMARCA4	1.27e-05	351	106	8	38297188
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PDE3B RANBP3 PRR5 MLXIP WWC2 ZFP36L2 SEC24B SEC16A AGFG1 IRS2 BRD1 PRRC1	1.28e-05	861	106	12	36931259
Pubmed	FGF signaling is strictly required to maintain early telencephalic precursor cell survival.	LHX5 EMX1 FOXD1	1.50e-05	16	106	3	19542358
Pubmed	Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs.	GLI2 GLI3 VEGFB	1.50e-05	16	106	3	17187775
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	NUP214 IGF2BP1 POM121 SEC16A PCNT	1.50e-05	101	106	5	26949739
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ELOA2 POU2AF1 POU4F2 GATA5 MLXIP AR HOXD1 GLI3 LHX5 BRD1 EMX1 ELL	1.54e-05	877	106	12	20211142
Pubmed	Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.	SYNPO2L IGF2BP1 COQ8A GLI3 IRS2 PRRC1	1.62e-05	174	106	6	29669786
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	PITPNM2 ENTR1 ATG2A MLXIP PTPDC1 WWC2 IGF2BP1 RPAP1 ZFP36L2 SEC24B SEC16A AGFG1 IRS2	1.70e-05	1038	106	13	26673895
Pubmed	Ablation of BAF170 in Developing and Postnatal Dentate Gyrus Affects Neural Stem Cell Proliferation, Differentiation, and Learning.	NR2E1 SMARCA4 EMX1	2.17e-05	18	106	3	27392482
Pubmed	All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3.	EVX1 GLI2 GLI3	2.17e-05	18	106	3	14723851
Pubmed	Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog.	GLI2 GLI3 EMX1	2.57e-05	19	106	3	32234482
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	POU4F2 FOXP4 GLI2 GLI3 SMARCA4 FOXD1	2.74e-05	191	106	6	24146773
Pubmed	Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway.	GLI2 GLI3	2.76e-05	3	106	2	11172440
Pubmed	Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.	GLI2 GLI3	2.76e-05	3	106	2	26010061
Pubmed	Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease.	NHLRC1 EPM2A	2.76e-05	3	106	2	28536304
Pubmed	Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG).	NHLRC1 EPM2A	2.76e-05	3	106	2	18070875
Pubmed	P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease.	NHLRC1 EPM2A	2.76e-05	3	106	2	36638890
Pubmed	Homeostasis of the astrocytic glutamate transporter GLT-1 is altered in mouse models of Lafora disease.	NHLRC1 EPM2A	2.76e-05	3	106	2	26976331
Pubmed	The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system.	NHLRC1 EPM2A	2.76e-05	3	106	2	19036738
Pubmed	Dual role of Brg chromatin remodeling factor in Sonic hedgehog signaling during neural development.	GLI3 SMARCA4	2.76e-05	3	106	2	21768360
Pubmed	A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus.	NUP214 AGFG1	2.76e-05	3	106	2	8943370
Pubmed	Gli family members are differentially expressed during the mitotic phase of spermatogenesis.	GLI2 GLI3	2.76e-05	3	106	2	9178901
Pubmed	Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.	GLI2 GLI3	2.76e-05	3	106	2	8378770
Pubmed	Early-onset Lafora body disease.	NHLRC1 EPM2A	2.76e-05	3	106	2	22961547
Pubmed	Skeletal Muscle Glycogen Chain Length Correlates with Insolubility in Mouse Models of Polyglucosan-Associated Neurodegenerative Diseases.	NHLRC1 EPM2A	2.76e-05	3	106	2	31042462
Pubmed	Laforin is required for the functional activation of malin in endoplasmic reticulum stress resistance in neuronal cells.	NHLRC1 EPM2A	2.76e-05	3	106	2	22578008
Pubmed	A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.	GLI2 GLI3	2.76e-05	3	106	2	8387379
Pubmed	Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase.	GLI2 GLI3	2.76e-05	3	106	2	38968120
Pubmed	Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.	GLI2 GLI3	2.76e-05	3	106	2	16571352
Pubmed	OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR.	AR SMARCA4	2.76e-05	3	106	2	35233061
Pubmed	Malin and laforin are essential components of a protein complex that protects cells from thermal stress.	NHLRC1 EPM2A	2.76e-05	3	106	2	21652633
Pubmed	DNA Polymerases as targets for gene therapy of hepatocellular carcinoma.	POLA1 POLE2	2.76e-05	3	106	2	25924900
Pubmed	Different expression patterns of Gli1-3 in mouse embryonic maxillofacial development.	GLI2 GLI3	2.76e-05	3	106	2	22178118
Pubmed	RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor.	RANBP9 AR	2.76e-05	3	106	2	12361945
Pubmed	Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase.	GLI2 GLI3	2.76e-05	3	106	2	19955409
Pubmed	Sonic hedgehog through Gli2 and Gli3 is required for the proper development of placental labyrinth.	GLI2 GLI3	2.76e-05	3	106	2	25695606
Pubmed	FoxO3a-mediated autophagy is down-regulated in the laforin deficient mice, an animal model for Lafora progressive myoclonus epilepsy.	NHLRC1 EPM2A	2.76e-05	3	106	2	27107699
Pubmed	Human transcription factor protein interaction networks.	BICRA ENTR1 NUP214 ATXN1L KMT2C FOXP4 IGF2BP1 GLI2 GLI3 ZNF516 SEC24B SEC16A SMARCA4 UNK KIFC1	2.89e-05	1429	106	15	35140242
Pubmed	The ULK1-FBXW5-SEC23B nexus controls autophagy.	SEC24B SEC16A ULK1	3.02e-05	20	106	3	30596474
Pubmed	Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling.	GLI2 GLI3 VEGFB	3.52e-05	21	106	3	29487191
Interaction	TOP3B interactions	PITPNM2 FLNC SETD1B BICRA NUP214 ATG2A MLXIP STK11IP RYR1 KMT2C IGF2BP1 RPAP1 ZFP36L2 CDK13 ZNF516 SEC24B SEC16A OGDHL UNK UNKL ZFYVE26 IRS2 ULK1 ELL PCNT	8.24e-08	1470	104	25	int:TOP3B
GeneFamily	Forkhead boxes	FOXD2 FOXP4 FOXD1	5.89e-04	43	69	3	508
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_7DY_DN	GAK SETD1B BICRA RANBP3 ATG2A ATXN1L ARHGAP4 ZFP36L2 SMARCA4 UNK ULK1 MNDA HERPUD1	1.74e-06	634	106	13	M40866
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN	GAK BICRA RANBP3 ATG2A ATXN1L ARHGAP4 ZFP36L2 SMARCA4 UNK ZFYVE26 ULK1 MNDA HERPUD1 MAST3 PCNT	3.65e-06	905	106	15	M40865
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K27ME3	TCERG1L DACT2 EVX1 POU4F2 GATA5 IGF2BP1 LHX5 EMX1 JPH3	1.14e-05	345	106	9	M2009
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K27ME3	TCERG1L DACT2 EVX1 POU4F2 GATA5 IGF2BP1 LHX5 EMX1 JPH3	1.20e-05	347	106	9	MM860
Coexpression	LEF1_UP.V1_UP	FLNC WASF3 ZAP70 RYR1 ARHGAP4 WWC2 ADGRG2	1.43e-05	194	106	7	M2905
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	FOXD2 PRR5 EVX1 POU4F2 GATA5 IGF2BP1 HOXD1 LHX5	1.52e-05	272	106	8	M1938
Coexpression	GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN	SETD1B SH2D3C NUP214 MLXIP ZFP36L2 ULK1 MAST3	1.58e-05	197	106	7	M5853
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	FOXD2 PRR5 EVX1 POU4F2 GATA5 IGF2BP1 HOXD1 LHX5	1.97e-05	282	106	8	MM822
Coexpression	GARCIA_PINERES_PBMC_HPV_16_L1_VLP_AGE_18_25YO_2MO_DN	GAK BICRA ENTR1 WASF3 EVX1 AR MAGI2 IRS2	2.24e-05	287	106	8	M40958
Coexpression	THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN	PDE3B NUP214 CBFA2T3 ARHGAP4 ZFP36L2 CDK13 ULK1	3.92e-05	227	106	7	M11234
Coexpression	SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP	ATG2A ARID5A ZFP36L2 AGFG1 IRS2 HERPUD1	6.58e-05	169	106	6	M40877
Coexpression	MARSON_FOXP3_TARGETS_DN	PDE3B POU2AF1 ZAP70 ZFP36L2	6.84e-05	54	106	4	M2160
Coexpression	MARSON_FOXP3_TARGETS_DN	PDE3B POU2AF1 ZAP70 ZFP36L2	1.04e-04	60	106	4	MM847
Coexpression	GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_8H_UP	ATG2A MLXIP ARID5A AGFG1 BRD1 ELL	1.33e-04	192	106	6	M8272
Coexpression	GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN	SETD1B SH2D3C NUP214 MLXIP ZFP36L2 MAST3	1.53e-04	197	106	6	M5877
Coexpression	GSE33292_WT_VS_TCF1_KO_DN3_THYMOCYTE_UP	NUP214 MLXIP MAGI2 AGFG1 BRD1 PSD4	1.61e-04	199	106	6	M9420
Coexpression	GSE13522_CTRL_VS_T_CRUZI_BRAZIL_STRAIN_INF_SKIN_DN	PDE3B POU2AF1 CBFA2T3 WWC2 AGFG1 EMX1	1.61e-04	199	106	6	M2921
Coexpression	GSE40655_FOXO1_KO_VS_WT_NTREG_UP	AR KMT2C ZFP36L2 UNK MAST3 PCNT	1.66e-04	200	106	6	M9439
Coexpression	GSE9988_LPS_VS_CTRL_TREATED_MONOCYTE_DN	SETD1B TMEM121B NUP214 MLXIP BRD1 MAST3	1.66e-04	200	106	6	M5859
Coexpression	GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP	IRAK2 COQ8A ZNF516 IRS2 MAST3 VEGFB	1.66e-04	200	106	6	M9748
Coexpression	ZENG_GU_ICB_CONTROL_METAGENE_31_PRECICTIVE_ICB_RESISTANCE	NHLRC1 DACT2 POU2AF1 KLHL29 CTNND2 FAM181B	1.70e-04	201	106	6	MM17086
Coexpression	LI_WILMS_TUMOR	WASF3 ADGRG2 GLI3	1.75e-04	27	106	3	M10773
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXD2 PITPNM2 RASGRF2 BEND4 CBFA2T3 ZNF516 SP5	3.07e-07	185	106	7	bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Deep_Layer-27\|World / Primary Cells by Cluster	TCERG1L NPDC1 PODXL2 IGF2BP1 SMARCA4 LHX5 EMX1	3.94e-07	192	106	7	cf989f26c0ebdc0cd12e1e41958f063e4fa3e468
ToppCell	droplet-Heart-HEART-1m-Hematologic-red_blood_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR9 PODXL2 MICALL2 KIFC1 PCNT	4.37e-06	101	106	5	6c4524be89cf3eb06769c2963dcded3da1e71ca0
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 NPDC1 CBFA2T3 HERPUD1 PRRC1 VEGFB	6.11e-06	189	106	6	e11998c57609c5714705713ac3a32016d6d841dd
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3B ZAP70 ARHGAP4 FOXP4 ZFHX2	7.57e-06	113	106	5	357bc20edc5bc14eab8262d52260ed1686e9dc54
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3B ZAP70 ARHGAP4 FOXP4 ZFHX2	7.57e-06	113	106	5	91e73e3b93be242fef0f14eddd8085a1f1c730ef
ToppCell	mild_COVID-19-CD8+_Tem\|World / disease group, cell group and cell class (v2)	PDE3B NPDC1 ATG2A ZAP70 ARID5A ZFP36L2	7.74e-06	197	106	6	97fead264e986d922669a6006cbcec530c697df7
ToppCell	mild_COVID-19-CD8+_Tem\|mild_COVID-19 / disease group, cell group and cell class (v2)	PDE3B PRR5 NPDC1 ATG2A ZAP70 ZFP36L2	7.97e-06	198	106	6	12847340c36a6791d8bdcb81e731e2fdeec46326
ToppCell	mLN-Dendritic_cell-pDC\|Dendritic_cell / Region, Cell class and subclass	KMT2C ZFP36L2 ULK1 HERPUD1 MAST3 VEGFB	8.44e-06	200	106	6	10ae1ac8a98346320a92e855aebb3a7109f0ab9b
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCERG1L RASGRF2 RANBP3 PRR5 POU2AF1	4.17e-05	161	106	5	249c2b97cc25de5053f5048ee354615df49b2081
ToppCell	facs-Heart-LA-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2L EVX1 COQ8A MTUS2 VEGFB	4.83e-05	166	106	5	829a8998ce68739a58202851afd73e049ab0f84f
ToppCell	facs-Heart-LA-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2L EVX1 COQ8A MTUS2 VEGFB	4.83e-05	166	106	5	c43aec09578975df8984886993d15b42a10190c8
ToppCell	facs-Marrow-KLS-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WASF3 CBFA2T3 CTNND2 MNDA KIFC1	5.26e-05	169	106	5	d6ad3b637de2935c656aad47ad82d6e8a8bd1227
ToppCell	facs-Marrow-KLS-24m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WASF3 CBFA2T3 CTNND2 MNDA KIFC1	5.26e-05	169	106	5	60ef186518d0dc63dbded2a77c65cfe3129df754
ToppCell	droplet-Fat-Scat-21m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNM2 RASGRF2 SYNPO2L MICALL2 FAM181B	5.87e-05	173	106	5	f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCell	droplet-Kidney-nan-21m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXD2 RASGRF2 BICRA WASF3 FAM181B	6.90e-05	179	106	5	b7281160c84dd053a2981c9c76ea6cc6d2592cd5
ToppCell	facs-Heart-RA-18m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR9 COQ8A FRMPD3 MTUS2 VEGFB	7.86e-05	184	106	5	72b42dfca7e9c0257f11d8242531e843271871a7
ToppCell	facs-Heart-RA-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR9 COQ8A FRMPD3 MTUS2 VEGFB	7.86e-05	184	106	5	c6f4537ae8b6e8fde1be17df14629b7b49b4997c
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma\|TCGA-Prostate / Sample_Type by Project: Shred V9	ENTR1 PODXL2 SEC16A SMARCA4 FRMPD3	8.06e-05	185	106	5	9d53e0a92e4f99370be2e4be1dd737630796b1ca
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRR5 NPDC1 ATG2A ZAP70 PCNT	8.48e-05	187	106	5	8c69fd469df2915c56ede534cee3ef23d5f64ebf
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	8.70e-05	188	106	5	73f6ec915934154f435a376cb274b058ff7c5f35
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	8.70e-05	188	106	5	789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	9.14e-05	190	106	5	474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	9.14e-05	190	106	5	a3c6eec6df052105ab78b7e3c78f94218d5912eb
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	9.14e-05	190	106	5	106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCell	T_cells-Central_memory_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	PDE3B RASGRF2 NPDC1 MLXIP COQ8A	9.37e-05	191	106	5	25dd538d6a361bd3367c8a1c0dfc9e7003061af3
ToppCell	10x5'v1-week_12-13-Mesenchymal_fibro-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FLNC DACT2 TACC2 ADGRG2 GLI3	9.60e-05	192	106	5	4ed5040594ba2d0639f0990697504ecef872ca70
ToppCell	10x5'v1-week_12-13-Mesenchymal_fibro\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FLNC DACT2 TACC2 ADGRG2 GLI3	9.60e-05	192	106	5	d4f5d6653564c2c5d0f5f7c932d89cb1b1412844
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	9.60e-05	192	106	5	c618ede75dce3988c87a5b8f98d8e94e1dd66efd
ToppCell	LPS-IL1RA+antiTNF-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	9.60e-05	192	106	5	04f5a2e3dd6beff027b89d66eefdd92036e041af
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B NPDC1 CTNND2 FAM181B	9.60e-05	192	106	5	0aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	9.60e-05	192	106	5	c07d7b40b2aa4eb27ac85801c014a656e2fd01dc
ToppCell	LPS-antiTNF-Endothelial-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	9.84e-05	193	106	5	02f633b016ab19bfa65bfd0cf32f000549a62148
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	9.84e-05	193	106	5	af5108260783e69a7d67896c5bf64f862525926d
ToppCell	LPS-antiTNF-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	9.84e-05	193	106	5	5122b1ffba42de190061be34ecdc6176f84e56a3
ToppCell	10x5'v1-week_12-13-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FLNC NPDC1 TACC2 ADGRG2 GLI3	9.84e-05	193	106	5	3d85c28f6ebdcb15e875ad01d52d6c138fbf8525
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	1.01e-04	194	106	5	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	1.01e-04	194	106	5	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	LPS_only-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	1.01e-04	194	106	5	58f069efdefa0366033764446b9d6ffd4a17807e
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM2 PDE3B SH2D3C NPDC1 CTNND2	1.01e-04	194	106	5	bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	ARID5A KLHL29 ZNF469 GLI3 ZNF516	1.03e-04	195	106	5	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	myeloid-Monocyte-CD14+_Monocyte\|myeloid / Lineage, cell class and subclass	NUP214 AGFG1 IRS2 ULK1 MNDA	1.03e-04	195	106	5	15ba9c5f6ecb6ae2c603e6b036eb92b00b46f13f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE3B ATG2A ZAP70 ZFP36L2 BRD1	1.06e-04	196	106	5	e4c76e7ad68455e51fe93ce588bcec9383f8654b
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Deep_Layer\|World / Primary Cells by Cluster	TCERG1L NPDC1 PODXL2 SMARCA4 EMX1	1.08e-04	197	106	5	41e823b14697827f657b13adb3afa581bd91a9cb
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	WWC2 FOXP4 SMARCA4 OGDHL FRMPD3	1.08e-04	197	106	5	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	T_cells-CCR7+_T_cells\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	PDE3B RASGRF2 ZAP70 ARID5A IRS2	1.08e-04	197	106	5	904430779c42b51d3eec62cf0cdd501b17058d8b
ToppCell	myeloid-Monocyte\|myeloid / Lineage, cell class and subclass	NUP214 AGFG1 IRS2 ULK1 MNDA	1.08e-04	197	106	5	6acf059cee6ba6bdeacc089b090d72336790972a
ToppCell	severe_COVID-19-CD8+_Tem\|severe_COVID-19 / disease group, cell group and cell class (v2)	PRR5 NPDC1 ZAP70 ZFP36L2 BRD1	1.11e-04	198	106	5	69d49f37cf5095e65c71cddc6d43748322ff19a3
ToppCell	(220)_CD8+_Cytotoxic_T_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	PRR5 NPDC1 ATG2A ZAP70 ZFP36L2	1.11e-04	198	106	5	2af389b8ea5767ba56fe64d719afe5be3f9a43ec
ToppCell	severe-B_memory\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	POU2AF1 BEND4 CBFA2T3 HERPUD1 VEGFB	1.14e-04	199	106	5	6d3436dd65d525aaa23ec02672005380f21c4d0f
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PDE3B PRR5 ATG2A ZAP70 ZFP36L2	1.14e-04	199	106	5	1c12b15004fa6ca9ae72a6d6f8f9a5fdeb755bd1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE3B PRR5 ATG2A ZAP70 ZFP36L2	1.14e-04	199	106	5	c8c89779dda4dcfb26bf86492c2e5a4f158eb8d2
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Mesenchymal-Mesoderm\|10w / Sample Type, Dataset, Time_group, and Cell type.	TCERG1L POLA1 SYNPO2L BEND4 SP5	1.16e-04	200	106	5	9ef226ebb0a7cdb9431e2fa65faa2a7d67da590d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial-Astrocyte\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	BICRA ZFP36L2 GLI3 NR2E1 FAM181B	1.16e-04	200	106	5	98a994692440cb4f505b050276f0c8022c814a21
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-dn_T\|Int-URO / Disease, condition lineage and cell class	POLA1 POU2AF1 RPAP1 ZFYVE26 CCDC180	1.16e-04	200	106	5	020439d9e70fff7246650ab0e9105236688c3ec3
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	BICRA ZFP36L2 GLI3 NR2E1 FAM181B	1.16e-04	200	106	5	ef222dc4a205d670172dae74990bdb952ac92e5b
Drug	diclofenac sodium; Down 200; 10uM; MCF7; HG-U133A	FLNC BICRA RANBP3 HOXD1 MICALL2 ZFP36L2 IRS2 PSD4 VEGFB	2.59e-07	195	103	9	333_DN
Drug	Acyclovir [59277-89-3]; Up 200; 17.8uM; MCF7; HT_HG-U133A	FLNC KLHL29 MAGI2 HOXD1 ZFP36L2 OGDHL IRS2 MNDA	3.21e-06	197	103	8	5643_UP
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A	EPM2A PODXL2 ZFP36L2 UNKL IRS2 HERPUD1 VEGFB	2.00e-05	183	103	7	6985_UP
Drug	CP-690334-01 [459212-38-5]; Up 200; 10uM; PC3; HT_HG-U133A	ELOA2 KLHL29 GLI2 ZNF516 CTNND2 EMX1 JPH3	3.00e-05	195	103	7	4558_UP
Drug	felodipine; Down 200; 10uM; MCF7; HT_HG-U133A_EA	ATG2A WWC2 CDK13 AGFG1 CTNND2 ELL VEGFB	3.10e-05	196	103	7	848_DN
Drug	Nalidixic acid sodium salt hydrate; Up 200; 14.6uM; PC3; HT_HG-U133A	PDE3B EPM2A AR KLHL29 HOXD1 GLI2 CTNND2	3.10e-05	196	103	7	3668_UP
Drug	Benzethonium chloride [121-54-0]; Down 200; 9uM; MCF7; HT_HG-U133A	PDE3B EPM2A BICRA RANBP3 GLI3 AGFG1 MAST3	3.21e-05	197	103	7	7207_DN
Drug	Carteolol hydrochloride [51781-21-6]; Up 200; 12.2uM; PC3; HT_HG-U133A	ELOA2 NUP214 HOXD1 ZNF516 CTNND2 MNDA MAST3	3.31e-05	198	103	7	4096_UP
Drug	Xylometazoline hydrochloride [1218-35-5]; Down 200; 14.2uM; MCF7; HT_HG-U133A	PDE3B EPM2A RANBP3 PODXL2 AR HOXD1 ELL	3.42e-05	199	103	7	2270_DN
Drug	prochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT_HG-U133A	PDE3B BICRA PRR5 PODXL2 RPAP1 GLI3 ZNF516	3.42e-05	199	103	7	5575_DN
Disease	Colorectal Carcinoma	FLNC ELOA2 TCERG1L RASGRF2 GATA5 CBFA2T3 KMT2C RPAP1 HOXD1 ZFP36L2 GLI3 CTNND2 JPH3	1.05e-06	702	103	13	C0009402
Disease	Lafora disease	NHLRC1 EPM2A	1.21e-05	2	103	2	cv:C0751783
Disease	Lafora disease (is_implicated_in)	NHLRC1 EPM2A	1.21e-05	2	103	2	DOID:3534 (is_implicated_in)
Disease	Lafora Body Disease, Late Onset	NHLRC1 EPM2A	1.21e-05	2	103	2	C0751784
Disease	Lafora Disease	NHLRC1 EPM2A	1.21e-05	2	103	2	C0751783
Disease	pancreas fat measurement	NHLRC1 EPM2A CBFA2T3	1.82e-05	15	103	3	EFO_0600049
Disease	Progressive myoclonic epilepsy	NHLRC1 EPM2A	7.21e-05	4	103	2	cv:C0751778
Disease	Lafora disease (implicated_via_orthology)	NHLRC1 EPM2A	7.21e-05	4	103	2	DOID:3534 (implicated_via_orthology)
Disease	response to mepolizumab	NHLRC1 EPM2A	1.20e-04	5	103	2	EFO_0008459
Disease	free cholesterol to total lipids in large VLDL percentage	SEC16A SMARCA4 HERPUD1	2.94e-04	37	103	3	EFO_0022281
Disease	primary bacterial infectious disease (implicated_via_orthology)	GLI2 GLI3	4.28e-04	9	103	2	DOID:0050338 (implicated_via_orthology)
Disease	Colorectal Neoplasms	FLNC TCERG1L GATA5 HOXD1 ZFP36L2 JPH3	4.33e-04	277	103	6	C0009404
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	SMARCA4 HERPUD1 MAST3	5.62e-04	46	103	3	EFO_0008317, EFO_0008596, EFO_0020943
Disease	total cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement	PAQR9 SETD1B RPAP1	6.77e-04	49	103	3	EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612
Disease	cholesteryl esters to total lipids in small VLDL percentage	SEC16A SMARCA4 HERPUD1	6.77e-04	49	103	3	EFO_0022256
Disease	rheumatoid arthritis (implicated_via_orthology)	ZAP70 KMT2C	7.78e-04	12	103	2	DOID:7148 (implicated_via_orthology)
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	NUP214 ZFP36L2 SMARCA4	8.52e-04	53	103	3	C1961099
Disease	ovarian carcinoma	NHLRC1 EPM2A POU2AF1 TACC2 GLI3 MTUS2	9.34e-04	321	103	6	EFO_0001075
Disease	triglycerides to total lipids in small VLDL percentage	SMARCA4 HERPUD1 VEGFB	1.11e-03	58	103	3	EFO_0022338
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	PITPNM2 SEC16A SMARCA4 HERPUD1 VEGFB	1.11e-03	222	103	5	EFO_0008317, EFO_0020943
Disease	reticulocyte measurement	PAQR9 PITPNM2 PDE3B CBFA2T3 ATXN1L AR FOXP4 ZNF469 ZFP36L2 IRS2 ELL	1.13e-03	1053	103	11	EFO_0010700
Disease	level of Phosphatidylcholine (16:0_16:0) in blood serum	SMARCA4 HERPUD1	1.23e-03	15	103	2	OBA_2045067
Disease	lateral occipital cortex volume measurement	NHLRC1 EPM2A	1.59e-03	17	103	2	EFO_0010311
Disease	Familial Progressive Myoclonic Epilepsy	NHLRC1 EPM2A	1.59e-03	17	103	2	C0751777
Disease	Atypical Inclusion-Body Disease	NHLRC1 EPM2A	1.59e-03	17	103	2	C0751776
Disease	Myoclonic Epilepsies, Progressive	NHLRC1 EPM2A	1.59e-03	17	103	2	C0751778
Disease	Biotin-Responsive Encephalopathy	NHLRC1 EPM2A	1.59e-03	17	103	2	C0751780
Disease	May-White Syndrome	NHLRC1 EPM2A	1.59e-03	17	103	2	C0751782
Disease	Dentatorubral-Pallidoluysian Atrophy	NHLRC1 EPM2A	1.59e-03	17	103	2	C0751781
Disease	very low density lipoprotein cholesterol measurement, esterified cholesterol measurement	SMARCA4 HERPUD1	1.78e-03	18	103	2	EFO_0008317, EFO_0008589
Disease	Action Myoclonus-Renal Failure Syndrome	NHLRC1 EPM2A	1.78e-03	18	103	2	C0751779
Disease	sodium-coupled monocarboxylate transporter 1 measurement	SMARCA4 HERPUD1	1.99e-03	19	103	2	EFO_0802076
Disease	prostate cancer (is_marker_for)	AR KMT2C CDK13 SMARCA4	2.21e-03	156	103	4	DOID:10283 (is_marker_for)
Disease	cholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage	SMARCA4 HERPUD1	2.43e-03	21	103	2	EFO_0022246

Protein segments in the cluster

Peptide	Gene	Start	Entry
VSAHPVLSFFPTAPA	EPM2A	246	B3EWF7
SAHGTPASASALPEP	BRD1	106	O95696
IPAFPAHFLATAGPS	ARID5A	531	Q03989
ATHATPGAPADTPGL	ELL	476	P55199
SHAAAAGGLPYPFPS	EVX1	261	P49640
SAATPSAAVGLFPAP	FAM220BP	91	B1ANY3
PFAPHAAVSISSSEP	BEND4	61	Q6ZU67
LADHPRGPPFSSSQS	ADGRG2	246	Q8IZP9
HVNAFGFPPTEPSST	POLE2	236	P56282
PSASATSAGSFTPHP	CCDC180	1336	Q9P1Z9
HSGGPPQPSAFSESF	CDK13	1386	Q14004
SAFHLPDAPPAAAAA	CTNND2	236	Q9UQB3
TSAPSSGPPDLATHF	ATG2A	441	Q2TAZ0
PDHAVPAAFPATDST	MTUS2	221	Q5JR59
HALEPPAPAGASAST	RANBP3	61	Q9H6Z4
PALVAGSSAAAPFPH	RANBP9	121	Q96S59
AAAAAAAAFHPHSPP	FOXD1	296	Q16676
LAATAASGAFVPPPS	HERPUD1	186	Q15011
LPSFPQTTAPSGAEH	PODXL2	306	Q9NZ53
GFPENATAPRSPSHS	ELOA2	111	Q8IYF1
GLSPTDAPHAGVSPA	GLI3	221	P10071
AQSPPHSAGAPAAKG	KMT2C	3756	Q8NEZ4
PSSNASPPEGFASHS	MAGI2	901	Q86UL8
ATFPGPGSSPARAHQ	IRAK2	136	O43187
ADGHPGAFQTASPAP	HOXD1	171	Q9GZZ0
AAVGLFPASSSAVPP	IGF2BP1	371	Q9NZI8
APSPAHSFNKAPSAT	ATXN1L	191	P0C7T5
SGAPAPPTRHDFSFD	KIFC1	361	Q9BW19
AAAASHPAVPPSAPD	MICALL2	356	Q8IY33
AFSGSAQPRPPSVVH	OGDHL	81	Q9ULD0
AGSAAPHTPPEAAAG	PDE3B	181	Q13370
HVAFAGAPITRSPFP	FLNC	451	Q14315
SPSHPISAPQAAAAA	NUP214	1081	P35658
FAHGPPSQAQSPADS	LHX5	296	Q9H2C1
LSAGALSPAFTFPHP	GLI2	276	P10070
ADSFPDGLVHPPTSA	FOXP4	401	Q8IVH2
HPEAASAAPPGASLL	AR	41	P10275
GSHSPGEPVSPSFAN	PTPDC1	496	A2A3K4
APSAPTVAAPAHGKA	FAM181B	131	A6NEQ2
AFQEHGAPSSPGTAP	PITPNM2	811	Q9BZ72
AASQGATRPPSFTPH	CBFA2T3	86	O75081
AAASPHSGGRATPSP	PCNT	3271	O95613
PNPFSVHTATAVPSG	POLA1	191	P09884
PAPAPAASGAARNSH	PAQR9	16	Q6ZVX9
FDHAALSAPLPAPSS	NPDC1	306	Q9NQX5
RGHASSGAAPAPTAV	POU2AF1	36	Q16633
TFGNSAAPAAAPTPA	POM121	996	Q96HA1
TTGTPPDFFSAALHP	IRS2	776	Q9Y4H2
PPASGAATPARAHAS	MLXIP	41	Q9HAP2
HPPGATAFPFAHSPS	GATA5	86	Q9BWX5
FPSAHSAPPPSCSAD	GAK	996	O14976
SAPPPSCSADFLHLG	GAK	1001	O14976
PSPASGHFAHPSFAA	DACT2	471	Q5SW24
PASPAGSPSADFAVH	ENTR1	241	Q96C92
AGAATEHPPGSPTSA	FRMPD3	1781	Q5JV73
AASPGDSPVFEPHIA	FUT11	406	Q495W5
APPDASAASTDASHP	DUX4L9	336	Q6RFH8
ASAPDQSAPPSLGHA	COQ8A	96	Q8NI60
SPASPAAAGHTRPSS	MAST3	1146	O60307
PHPSAAEAAFVSGFP	EMX1	86	Q04741
RAGDHPFSSPSPASG	DCLRE1A	181	Q6PJP8
GRTPAPSYPHAASAG	BICRA	1516	Q9NZM4
GSSHPAASARIPPKF	SEC24B	6	O95487
HFSPPCFVAALPAAG	RYR1	1776	P21817
PAAHRAAPSAPGALT	NHLRC1	101	Q6VVB1
AAAHFPSAALPAPAF	NR2E1	116	Q9Y466
PSGASTSAAVDHPPL	MNDA	161	P41218
SVFAGAGSAPAPAPA	FOXD2	326	O60548
FTSGVPSHAPVSGSP	SYNPO2L	521	Q9H987
QTGFVALPSHPADSP	STK11IP	56	Q8N1F8
APHAPRFPASAAAAA	SP5	216	Q6BEB4
PAAPAAAASAAPSHS	SUPT20HL1	491	Q3ZLR7
GHPRSVSSASGSFPP	TMEM121B	6	Q9BXQ6
QGPTGTFRSSPAPHS	PRR5	301	P85299
AFAIATAAAGHGSPP	RASGRF2	881	O14827
AGPDGAVVSTPAHAP	POU4F2	206	Q12837
AATHSAPPFPAAVGS	PSD4	891	Q8NDX1
SGSASFAHTAPPPAG	SMARCA4	1266	P51532
ATFAHTPPPAQATPA	SETD1B	376	Q9UPS6
PSTAAAFGNPPVSHF	PRRC1	96	Q96M27
APVAPHFALTPAFAS	SCFD2	161	Q8WU76
GTAVCPFSPHSSPSF	RUSC1-AS1	116	Q66K80
FSRGPGAPASPSASH	ARHGAP4	921	P98171
PFGATPSTNPFVAAA	AGFG1	426	P52594
LPPSHLGSSSPFSAN	NDUFV1-DT	131	Q8NBR9
APDSAAAAAAHPFPA	TCERG1L	96	Q5VWI1
PPAGAGFAPTNKHSA	ZNF516	956	Q92618
NASGAAAPTLPAHPS	ZAP70	261	P43403
AAAATGHTPPLAEAP	WWC2	526	Q6AWC2
PGHNAPSLPSDTFSS	ZFHX2	16	Q9C0A1
KFPTSAPGSLSPDAH	ZFHX2	676	Q9C0A1
QPRAHASPFSGALTP	SEC16A	116	O15027
FPASASSTHAAPPHP	WASF3	371	Q9UPY6
ISPAAAHAGLPPSAA	TACC2	1901	O95359
DSVEGSPFRPPSHSF	TACC2	2006	O95359
CVAPGAAPHLTPFSA	RPAP1	931	Q9BWH6
APHSDSPLGFSHAAP	TNXA	11	Q16473
AAVHPPAPSVSSSVA	UNKL	366	Q9H9P5
SSPGAAHSAPRPFSD	ZNF469	356	Q96JG9
APGPSAHAAPSTTSA	VEGFB	171	P49765
HAAPAAPSATALPAS	SH2D3C	426	Q8N5H7
LGSSASFHSASPSPP	UNK	566	Q9C0B0
VGTPVAAAPSSGFAP	ZFP36L2	36	P47974
EFSPAAPPGISSIHS	ZFYVE26	1766	Q68DK2
LGFARASPSPPAHAE	ULK1	471	O75385
SSCTPAGPHAAPAAL	ZNF541	316	Q9H0D2
AATATSPPPHFPHAA	UBALD1	101	Q8TB05
AHSYGVAQPPTFSPA	KLHL29	161	Q96CT2
ASPVPAPSSGLHAAV	KIAA1522	861	Q9P206
ALHPDASPAVAGSPA	JPH3	176	Q8WXH2