Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	steroid hormone binding	ATP1A1 ATP1A3	1.39e-04	7	52	2	GO:1990239
GeneOntologyMolecularFunction	P-type sodium transporter activity	ATP1A1 ATP1A3	2.95e-04	10	52	2	GO:0008554
GeneOntologyMolecularFunction	P-type sodium:potassium-exchanging transporter activity	ATP1A1 ATP1A3	2.95e-04	10	52	2	GO:0005391
GeneOntologyMolecularFunction	P-type potassium transmembrane transporter activity	ATP1A1 ATP1A3	3.60e-04	11	52	2	GO:0008556
GeneOntologyBiologicalProcess	organophosphate metabolic process	PNPLA6 PIK3C2B MTHFD1 NT5C3A ENTPD1 PIPOX RBKS PLCG1 IDH2 INPP5F MDH2 LDHC	2.06e-05	1142	52	12	GO:0019637
GeneOntologyBiologicalProcess	phosphatidylinositol-mediated signaling	PIK3C2B PLCG1 INPP5F	2.95e-05	24	52	3	GO:0048015
GeneOntologyBiologicalProcess	phosphatidylinositol catabolic process	PLCG1 INPP5F	3.73e-05	4	52	2	GO:0031161
GeneOntologyBiologicalProcess	response to glycoside	ATP1A1 ATP1A3	6.20e-05	5	52	2	GO:1903416
GeneOntologyBiologicalProcess	glycerophospholipid catabolic process	PNPLA6 PLCG1 INPP5F	1.11e-04	37	52	3	GO:0046475
GeneOntologyCellularComponent	photoreceptor inner segment membrane	ATP1A1 ATP1A3	3.63e-05	4	52	2	GO:0060342
GeneOntologyCellularComponent	sodium:potassium-exchanging ATPase complex	ATP1A1 ATP1A3	3.94e-04	12	52	2	GO:0005890
MousePheno	abnormal muscle contractility	CACNB1 FBXO10 ENTPD1 TRPM2 PARD3B RBKS ATP1A1 SOD1	2.89e-05	418	42	8	MP:0005620
Domain	P-type_ATPase_IIC	ATP1A1 ATP1A3	1.05e-04	6	50	2	IPR005775
Domain	L-lactate/malate_DH	MDH2 LDHC	1.95e-04	8	50	2	IPR001557
Domain	Ldh_1_N	MDH2 LDHC	1.95e-04	8	50	2	PF00056
Domain	Lactate/malate_DH_N	MDH2 LDHC	1.95e-04	8	50	2	IPR001236
Domain	-	MDH2 LDHC	2.50e-04	9	50	2	3.90.110.10
Domain	Lactate/malate_DH_C	MDH2 LDHC	2.50e-04	9	50	2	IPR022383
Domain	Lactate_DH/Glyco_Ohase_4_C	MDH2 LDHC	2.50e-04	9	50	2	IPR015955
Domain	Ldh_1_C	MDH2 LDHC	2.50e-04	9	50	2	PF02866
Domain	WAP	WFDC3 WFDC12	8.23e-04	16	50	2	SM00217
Domain	-	ATP1A1 ATP1A3	8.23e-04	16	50	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP1A1 ATP1A3	8.23e-04	16	50	2	IPR023298
Domain	WAP	WFDC3 WFDC12	8.23e-04	16	50	2	PF00095
Domain	ATPase_P-typ_cation-transptr_C	ATP1A1 ATP1A3	9.31e-04	17	50	2	IPR006068
Domain	Cation_ATPase_C	ATP1A1 ATP1A3	9.31e-04	17	50	2	PF00689
Domain	WAP	WFDC3 WFDC12	9.31e-04	17	50	2	PS51390
Domain	-	WFDC3 WFDC12	9.31e-04	17	50	2	4.10.75.10
Domain	Cation_ATPase_N	ATP1A1 ATP1A3	1.05e-03	18	50	2	PF00690
Domain	Cation_ATPase_N	ATP1A1 ATP1A3	1.05e-03	18	50	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP1A1 ATP1A3	1.17e-03	19	50	2	IPR004014
Domain	HAD-like_dom	NT5C3A ATP1A1 ATP1A3	1.24e-03	79	50	3	IPR023214
Domain	WAP_dom	WFDC3 WFDC12	1.57e-03	22	50	2	IPR008197
Domain	-	ATP1A1 ATP1A3	3.31e-03	32	50	2	3.40.1110.10
Domain	-	ATP1A1 ATP1A3	3.31e-03	32	50	2	2.70.150.10
Domain	ATPase_P-typ_cyto_domN	ATP1A1 ATP1A3	3.95e-03	35	50	2	IPR023299
Domain	P_typ_ATPase	ATP1A1 ATP1A3	4.18e-03	36	50	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP1A1 ATP1A3	4.18e-03	36	50	2	IPR018303
Domain	ATPASE_E1_E2	ATP1A1 ATP1A3	4.18e-03	36	50	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP1A1 ATP1A3	4.41e-03	37	50	2	IPR008250
Domain	E1-E2_ATPase	ATP1A1 ATP1A3	4.41e-03	37	50	2	PF00122
Pubmed	DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.	EEF2 UBR5 MTHFD1 HAT1 ATP1A1 ATP1A3 HNRNPK	8.00e-09	175	52	7	25756610
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	EEF2 UBR5 MTHFD1 DNAJA2 NCAPD2 HAT1 IDH2 HARS1 ATP1A1 MDH2 HNRNPK SOD1	9.72e-08	1149	52	12	35446349
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	EEF2 MTHFD1 DNAJA2 EIF2S3B ATP1A1 MDH2 LDHC HNRNPK FBXO2	3.23e-07	621	52	9	22794259
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	EEF2 MTHFD1 ATP1A1 MDH2 HNRNPK	5.04e-07	104	52	5	36055981
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	EEF2 MTHFD1 DNAJA2 NCAPD2 HAT1 POGZ PLCG1 IDH2 HARS1 ATP1A1 MDH2 HNRNPK	9.64e-07	1425	52	12	30948266
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	EEF2 UBR5 DNAJA2 ATP1A1 ATP1A3 MDH2	9.81e-07	221	52	6	29991511
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	EEF2 PNPLA6 ZC2HC1A MTHFD1 DNAJA2 EIF2S3B IDH2 ATP1A1 ATP1A3 MDH2 HNRNPK SOD1	1.01e-06	1431	52	12	37142655
Pubmed	Immunohistochemical analyses of alpha1 and alpha3 Na+/K+-ATPase subunit expression in medulloblastomas.	ATP1A1 ATP1A3	2.19e-06	2	52	2	21498719
Pubmed	All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides.	ATP1A1 ATP1A3	2.19e-06	2	52	2	11546672
Pubmed	Properties and expression of Na+/K+-ATPase α-subunit isoforms in the brain of the swamp eel, Monopterus albus, which has unusually high brain ammonia tolerance.	ATP1A1 ATP1A3	2.19e-06	2	52	2	24391932
Pubmed	Na+/K+ ATPase α1 and α3 isoforms are differentially expressed in α- and γ-motoneurons.	ATP1A1 ATP1A3	2.19e-06	2	52	2	23761886
Pubmed	The family of human Na+,K+-ATPase genes. A partial nucleotide sequence related to the alpha-subunit.	ATP1A1 ATP1A3	2.19e-06	2	52	2	3030810
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	EEF2 MTHFD1 DNAJA2 HAT1 EIF2S3B IDH2 ATP1A1 HNRNPK SOD1	2.70e-06	803	52	9	36517590
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	EEF2 MTHFD1 DNAJA2 ZFHX3 IDH2 HARS1 ATP1A1 MDH2 HNRNPK	2.81e-06	807	52	9	30575818
Pubmed	K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.	UBR5 MTHFD1 DNAJA2 ATP1A1	2.81e-06	65	52	4	29378950
Pubmed	Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.	EEF2 MTHFD1 IPO13 HAT1 MDH2 HNRNPK	3.19e-06	271	52	6	26816005
Pubmed	Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.	EEF2 UBR5 HAT1	4.11e-06	21	52	3	30179224
Pubmed	Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.	EEF2 MTHFD1 IDH2 ATP1A1 HNRNPK	4.22e-06	160	52	5	23798571
Pubmed	MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.	EEF2 MTHFD1 DNAJA2 HAT1 ATP1A3 HNRNPK	4.44e-06	287	52	6	36180891
Pubmed	Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.	ATP1A1 ATP1A3	6.57e-06	3	52	2	2822726
Pubmed	Na+/K+-ATPase α isoform deficiency results in distinct spreading depolarization phenotypes.	ATP1A1 ATP1A3	6.57e-06	3	52	2	30819023
Pubmed	Oxidative stress mediates the disruption of airway epithelial tight junctions through a TRPM2-PLCγ1-PKCα signaling pathway.	TRPM2 PLCG1	6.57e-06	3	52	2	23629676
Pubmed	Glycoprotein nonmetastatic melanoma protein B (GPNMB) promotes the progression of brain glioblastoma via Na+/K+-ATPase.	ATP1A1 ATP1A3	6.57e-06	3	52	2	27836549
Pubmed	Identification of a VxP Targeting Signal in the Flagellar Na+ /K+ -ATPase.	ATP1A1 ATP1A3	6.57e-06	3	52	2	26373354
Pubmed	Differential expression of Na+/K+-ATPase alpha-subunits in mouse hippocampal interneurones and pyramidal cells.	ATP1A1 ATP1A3	6.57e-06	3	52	2	17947306
Pubmed	Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders.	ATP1A1 ATP1A3	6.57e-06	3	52	2	19058785
Pubmed	Knockout of sodium pump α3 subunit gene (Atp1a3-/-) results in perinatal seizure and defective respiratory rhythm generation.	ATP1A1 ATP1A3	6.57e-06	3	52	2	28465228
Pubmed	Expression Analyses of POGZ, A Responsible Gene for Neurodevelopmental Disorders, during Mouse Brain Development.	RELN POGZ	6.57e-06	3	52	2	31430754
Pubmed	Developmental cell-specific regulation of Na(+)-K(+)-ATPase alpha 1-, alpha 2-, and alpha 3-isoform gene expression.	ATP1A1 ATP1A3	6.57e-06	3	52	2	8203495
Pubmed	Decreased Expression of Synaptophysin 1 (SYP1 Major Synaptic Vesicle Protein p38) and Contactin 6 (CNTN6/NB3) in the Cerebellar Vermis of reln Haplodeficient Mice.	RELN CNTN6	6.57e-06	3	52	2	31098770
Pubmed	SIRT5 alleviates hepatic ischemia and reperfusion injury by diminishing oxidative stress and inflammation via elevating SOD1 and IDH2 expression.	IDH2 SOD1	6.57e-06	3	52	2	35995176
Pubmed	Na,K-ATPase and the role of alpha isoforms in behavior.	ATP1A1 ATP1A3	6.57e-06	3	52	2	18044013
Pubmed	Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase.	ATP1A1 ATP1A3	6.57e-06	3	52	2	26988030
Pubmed	Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model.	ATP1A1 ATP1A3	6.57e-06	3	52	2	26911348
Pubmed	Cardiac glycosides induced toxicity in human cells expressing α1-, α2-, or α3-isoforms of Na-K-ATPase.	ATP1A1 ATP1A3	6.57e-06	3	52	2	25994790
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	EEF2 MTHFD1 DNAJA2 EIF2S3B ATP1A1 ITGAV HNRNPK	7.95e-06	488	52	7	31324722
Pubmed	Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.	EEF2 UBR5 NCAPD2 HNRNPK	9.02e-06	87	52	4	24169447
Pubmed	Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice.	IDH2 ATP1A1 HNRNPK	1.01e-05	28	52	3	30947518
Pubmed	Hereditary Ataxia Overview	EEF2 PNPLA6 ZFHX3 ATP1A3	1.13e-05	92	52	4	20301317
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	EEF2 PNPLA6 UBR5 DNAJA2 ATP1A1	1.16e-05	197	52	5	31620119
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	EEF2 ZC2HC1A NT5C3A DNAJA2 EIF2S3B HARS1 MDH2 HNRNPK	1.23e-05	732	52	8	34732716
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	EEF2 MTHFD1 DNAJA2 HAT1 ATP1A1 HNRNPK	1.24e-05	344	52	6	36282215
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	MTHFD1 DNAJA2 PLCG1 ATP1A1 MDH2 HNRNPK	1.24e-05	344	52	6	30333137
Pubmed	AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.	EEF2 MTHFD1 ATP1A1 MDH2 HNRNPK	1.25e-05	200	52	5	35546148
Pubmed	Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2.	ATP1A1 ATP1A3	1.31e-05	4	52	2	21731499
Pubmed	The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice.	ATP1A1 ATP1A3	1.31e-05	4	52	2	12458206
Pubmed	A mouse homologue of Strawberry Notch is transcriptionally regulated by Reelin signal.	RELN SBNO2	1.31e-05	4	52	2	17045962
Pubmed	Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.	ATP1A1 ATP1A3	1.31e-05	4	52	2	21849490
Pubmed	Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes.	ATP1A1 ATP1A3	1.31e-05	4	52	2	17446412
Pubmed	Na,K-ATPase expression in the mouse cochlea is not dependent on the mineralocorticoid receptor.	ATP1A1 ATP1A3	1.31e-05	4	52	2	11591489
Pubmed	Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1.	ATP1A1 ATP1A3	1.31e-05	4	52	2	19751721
Pubmed	Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction.	ATP1A1 ATP1A3	1.31e-05	4	52	2	19376779
Pubmed	Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice.	ATP1A1 ATP1A3	1.31e-05	4	52	2	17234593
Pubmed	Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism.	ATP1A1 ATP1A3	1.31e-05	4	52	2	2887455
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	EEF2 UBR5 MTHFD1 POGZ ATP1A1 HNRNPK	1.53e-05	357	52	6	37059091
Pubmed	MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.	EEF2 MTHFD1 ENTPD1 ATP1A1 MDH2 ITGAV HNRNPK	2.04e-05	565	52	7	20458337
Pubmed	USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.	EEF2 MTHFD1 DNAJA2 HAT1 IDH2 ATP1A1 HNRNPK	2.04e-05	565	52	7	33567341
Pubmed	Multiple genes encode the human Na+,K+-ATPase catalytic subunit.	ATP1A1 ATP1A3	2.19e-05	5	52	2	3035563
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	EEF2 DNAJA2 ZFHX3 POGZ ATP1A1 ATXN1L HNRNPK	2.50e-05	583	52	7	29844126
Pubmed	Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.	RBKS IDH2 MDH2 LDHC	2.63e-05	114	52	4	28245920
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	EEF2 PNPLA6 ZC2HC1A UBR5 MTHFD1 DNAJA2 NCAPD2 POGZ PLCG1 HNRNPK	2.74e-05	1353	52	10	29467282
Pubmed	An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.	EEF2 MTHFD1 IDH2 ATP1A1 MDH2 HNRNPK	2.78e-05	397	52	6	21319273
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	EEF2 MTHFD1 DNAJA2 NCAPD2 PLCG1	2.82e-05	237	52	5	29564676
Pubmed	SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption.	MTHFD1 DNAJA2 ATP1A1 HNRNPK	3.21e-05	120	52	4	37929963
Pubmed	The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.	ATP1A1 ATP1A3	3.28e-05	6	52	2	3036582
Pubmed	Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.	PIK3C2B PLCG1	3.28e-05	6	52	2	8084603
Pubmed	Transport and pharmacological properties of nine different human Na, K-ATPase isozymes.	ATP1A1 ATP1A3	3.28e-05	6	52	2	10636900
Pubmed	Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells.	EEF2 MTHFD1 IDH2 MDH2 SOD1	3.43e-05	247	52	5	30713523
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	EEF2 MTHFD1 IDH2 ATP1A1 MDH2 ITGAV HNRNPK SOD1	3.86e-05	859	52	8	31536960
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	EEF2 MTHFD1 DNAJA2 NCAPD2 HAT1 ATP1A1 HNRNPK	4.42e-05	638	52	7	33239621
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	EEF2 MTHFD1 HARS1 ATP1A1 ATP1A3 MDH2 LDHC HNRNPK	4.50e-05	878	52	8	37223481
Pubmed	Differential involvement of Na(+),K(+)-ATPase isozymes in preimplantation development of the mouse.	ATP1A1 ATP1A3	4.58e-05	7	52	2	10837135
Pubmed	Molecular genetics of Na,K-ATPase.	ATP1A1 ATP1A3	4.58e-05	7	52	2	2158121
Pubmed	Expression and distribution of Na, K-ATPase isoforms in the human uterus.	ATP1A1 ATP1A3	4.58e-05	7	52	2	20065300
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	EEF2 UBR5 NT5C3A DNAJA2 NCAPD2 IPO13 HAT1 IDH2 ATP1A1 MDH2	4.64e-05	1440	52	10	30833792
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	EEF2 UBR5 MTHFD1 DNAJA2 NCAPD2 IDH2 MDH2	4.83e-05	647	52	7	26618866
Pubmed	Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.	EEF2 MTHFD1 IDH2 ATP1A1 HNRNPK	5.15e-05	269	52	5	30442662
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	AEBP1 UBR5 HAT1 ATP1A1 ATP1A3	5.15e-05	269	52	5	29511261
Pubmed	Systematic analyses of the ultraviolet radiation resistance-associated gene product (UVRAG) protein interactome by tandem affinity purification.	EEF2 ATP1A1 MDH2	5.20e-05	48	52	3	26590968
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	EEF2 UBR5 MTHFD1 DNAJA2 HAT1 ATP1A1 HNRNPK	5.22e-05	655	52	7	35819319
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	EEF2 UBR5 DNAJA2 NCAPD2 IPO13 ATP1A1 HNRNPK	5.32e-05	657	52	7	36180527
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	EEF2 UBR5 MTHFD1 IDH2 ATP1A1	5.43e-05	272	52	5	25315684
Pubmed	Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit.	ATP1A1 ATP1A3	6.10e-05	8	52	2	19683723
Pubmed	Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse.	ATP1A1 ATP1A3	6.10e-05	8	52	2	2885848
Pubmed	Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice.	ATP1A1 ATP1A3	6.10e-05	8	52	2	23652595
Pubmed	Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.	UBR5 MTHFD1 DNAJA2 IDH2 ATP1A1 HNRNPK	6.53e-05	463	52	6	27503909
Pubmed	Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes.	ZFHX3 ATP1A1 ATP1A3	6.62e-05	52	52	3	20114047
Pubmed	PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2.	EEF2 MTHFD1 DNAJA2 ATP1A1 HNRNPK	7.34e-05	290	52	5	32929329
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	PNPLA6 UBR5 NT5C3A DNAJA2 NCAPD2 HAT1 ATP1A1 ATP1A3	7.36e-05	942	52	8	31073040
Pubmed	The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm.	ATP1A1 ATP1A3	7.84e-05	9	52	2	15253893
Pubmed	FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.	RELN FBXO10	7.84e-05	9	52	2	20554749
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	UBR5 DNAJA2 HAT1 PLCG1 IDH2 ATP1A1 HNRNPK	8.20e-05	704	52	7	29955894
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNB1 EEF2 ZC2HC1A UBR5 SH3D19 DNAJA2 HNRNPK FBXO2	8.58e-05	963	52	8	28671696
Pubmed	Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.	EEF2 MDH2 HNRNPK SOD1	8.70e-05	155	52	4	22673621
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	EEF2 ZC2HC1A MTHFD1 DNAJA2 ATP1A1 ATP1A3 MDH2 HNRNPK SOD1	8.72e-05	1247	52	9	27684187
Pubmed	Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.	EEF2 MTHFD1 DNAJA2 ATP1A1	8.92e-05	156	52	4	37108203
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	EEF2 UBR5 MTHFD1 NT5C3A DNAJA2 HAT1 EIF2S3B ATP1A1 HNRNPK	9.27e-05	1257	52	9	37317656
Pubmed	Reproduction and immunity-driven natural selection in the human WFDC locus.	WFDC3 WFDC12	9.79e-05	10	52	2	23292442
Pubmed	Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons.	RELN PLCG1	9.79e-05	10	52	2	15062102
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	EEF2 MTHFD1 DNAJA2 HAT1 HARS1 ATP1A1 HNRNPK	9.84e-05	725	52	7	27025967
Interaction	CRY2 interactions	EEF2 UBR5 MTHFD1 HAT1 ATP1A1 ATP1A3 HNRNPK	6.38e-07	194	52	7	int:CRY2
Interaction	NFIX interactions	ZFHX3 POGZ IDH2 ATP1A1 ATXN1L HNRNPK	2.52e-05	227	52	6	int:NFIX
Interaction	GAA interactions	MTHFD1 PARD3B ITGAV HNRNPK FBXO2	2.53e-05	135	52	5	int:GAA
Cytoband	20q13.12	WFDC3 WFDC12	2.14e-03	60	52	2	20q13.12
GeneFamily	ATPase Na+/K+ transporting subunits	ATP1A1 ATP1A3	6.34e-05	7	32	2	1208
GeneFamily	WAP four-disulfide core domain containing\|Fibronectin type III domain containing	WFDC3 WFDC12	4.56e-04	18	32	2	361
GeneFamily	Cyclins\|F-boxes other	FBXO10 FBXO2	2.16e-03	39	32	2	560
Coexpression	GSE32901_NAIVE_VS_TH17_NEG_CD4_TCELL_UP	TNFRSF9 PIK3C2B ENTPD1 NCAPD2 HAT1	2.32e-05	172	52	5	M8932
Coexpression	BUSSLINGER_DUODENAL_DIFFERENTIATING_STEM_CELLS	EEF2 MTHFD1 IDH2 MDH2 HNRNPK SOD1	3.07e-05	305	52	6	M40025
Coexpression	GSE27786_CD8_TCELL_VS_MONO_MAC_DN	ZC2HC1A TRPM2 PARD3B ATXN1L SBNO2	4.78e-05	200	52	5	M4849
Coexpression	GSE7852_TREG_VS_TCONV_LN_UP	ZC2HC1A ENTPD1 INPP5F ITGAV ATXN1L	4.78e-05	200	52	5	M5727
Coexpression	GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_4H_UP	SH3D19 ENTPD1 MDH2 ITGAV SOD1	4.78e-05	200	52	5	M6955
ToppCell	Severe-Treg\|World / Disease group and Cell class	TNFRSF9 ZC2HC1A ENTPD1 RBKS SOD1	2.89e-06	191	52	5	0a80b8c317e8da4d4722cfd13cdabc32b58021eb
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-Treg\|T/NK_cells / Location, Cell class and cell subclass	TNFRSF9 ZC2HC1A ENTPD1 INPP5F SOD1	3.12e-06	194	52	5	e46963d5f156526342ebc0fb9e767d266e812c42
ToppCell	Severe-Treg\|Severe / Disease group and Cell class	TNFRSF9 ZC2HC1A ENTPD1 RBKS SOD1	3.12e-06	194	52	5	7d232d87262ec5f505901345da5113cabf821321
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EEF2 MTHFD1 SH3D19 ATP1A1 HNRNPK	3.45e-06	198	52	5	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EEF2 MTHFD1 SH3D19 ATP1A1 HNRNPK	3.53e-06	199	52	5	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4-POLYDENDROCYTE_(Neurogenesis.Sox4.Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	WFDC3 PIPOX HNRNPK SBNO2	1.34e-05	124	52	4	1483be8700eca7e2c288784a290d945d4022b17f
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFDC3 PDCL2 WFDC12 LDHC	2.62e-05	147	52	4	9bc4185920b2b0f1fd5c6e2ec5583b9cd49c2efd
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFDC3 PDCL2 WFDC12 LDHC	2.62e-05	147	52	4	9b0f87a6dd5224c2b06deafeae04a1b04e53eb75
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TNFRSF9 ZC2HC1A ENTPD1 PIPOX	3.39e-05	157	52	4	6a0aa66964eecbbc232abf1d2e6c8422e4ce69d0
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TNFRSF9 ZC2HC1A ENTPD1 PIPOX	3.74e-05	161	52	4	22fea192cd5f6d3544533d8b10e1d74dfedf0f05
ToppCell	Control-Treg\|World / Disease group and Cell class	TNFRSF9 ZC2HC1A PARD3B INPP5F	3.74e-05	161	52	4	ead9f5a491321f9e307f7c97e47a4ca124f59bb6
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TNFRSF9 ZC2HC1A ENTPD1 INPP5F	4.42e-05	168	52	4	63437b3c3a66f953eaed600965ab193f9cc49da2
ToppCell	ASK452-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	WFDC3 RELN AEBP1 PLCG1	5.65e-05	179	52	4	c3cf49c069e66db16d2fce1de4c52a4c4fe7e832
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AEBP1 KIAA1755 ITGAV ZSCAN23	5.77e-05	180	52	4	d1c52aeceb3627e3c5fb6cc3af77e0400f9380ab
ToppCell	COVID-19-Fibroblasts-Adventitial_FB\|COVID-19 / group, cell type (main and fine annotations)	BOC SH3D19 KIAA1755 PARD3B	6.42e-05	185	52	4	a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCell	Control-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	TNFRSF9 ZC2HC1A ENTPD1 INPP5F	6.42e-05	185	52	4	e481cacda0b6b25f5f0062b962df9a442053ac30
ToppCell	normal_Lung-T/NK_cells-Treg\|T/NK_cells / Location, Cell class and cell subclass	TNFRSF9 ZC2HC1A ENTPD1 SOD1	6.42e-05	185	52	4	ea416362d3f06b4a0a7f08c2e5dbbc864f121555
ToppCell	metastatic_Lymph_Node-B_lymphocytes-Undetermined\|metastatic_Lymph_Node / Location, Cell class and cell subclass	BOC NT5C3A ENTPD1 INPP5F	6.83e-05	188	52	4	0ddc5dbe2fd905fee20c33d9845629e259faacd9
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNB1 RELN THNSL1 IPO13	6.83e-05	188	52	4	c2febf9fd4632af1f922067c3a30e5c50f75f480
ToppCell	IPF-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	TNFRSF9 ZC2HC1A ENTPD1 INPP5F	6.98e-05	189	52	4	7a260485c2a7c743c14d048e5e480ae0a9b8e32c
ToppCell	(1)_T_cells-(1)_T_CD4_reg\|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	TNFRSF9 ZC2HC1A ENTPD1 SOD1	7.12e-05	190	52	4	ff42af092173c2d4472bb9a02f5a334c272e05a0
ToppCell	Control-Treg\|Control / Disease group and Cell class	TNFRSF9 ZC2HC1A INPP5F SOD1	7.41e-05	192	52	4	3a9a8ac2aa278adde848608f9bb92a002dbb9bcc
ToppCell	ILEUM-inflamed-(1)_Tregs\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TNFRSF9 ZC2HC1A ENTPD1 SOD1	7.41e-05	192	52	4	1fe3417dfd1cf1758fd82c9ac13dbd88bdf0b548
ToppCell	metastatic_Lymph_Node-T/NK_cells-Treg\|T/NK_cells / Location, Cell class and cell subclass	TNFRSF9 ZC2HC1A ENTPD1 SOD1	7.56e-05	193	52	4	bac302e69455aaaf1c18f3272bb213242664d747
ToppCell	18-Distal-Mesenchymal-Cartilage\|Distal / Age, Tissue, Lineage and Cell class	BOC RELN KIAA1755 FBXO2	7.56e-05	193	52	4	52f3d1bb8d8ca91ba12439d46392f377928ff8f8
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BOC AEBP1 KIAA1755 CNTN6	7.72e-05	194	52	4	7826fe5eb254ac032de0d978f39585a40e0b3ee4
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_Tregs\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TNFRSF9 ZC2HC1A ENTPD1 SOD1	7.72e-05	194	52	4	0396457834bbfed8d0b9b2ddaaecd9f28e1d56ed
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BOC RELN PIK3C2B ENTPD1	7.72e-05	194	52	4	b490fffc94f005dff9a34ce34d80ca776e3a1387
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BOC AEBP1 SH3D19 KIAA1755	7.87e-05	195	52	4	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	COVID-19-Lymphoid-Tregs\|Lymphoid / Condition, Lineage and Cell class	TNFRSF9 ZC2HC1A ENTPD1 SOD1	7.87e-05	195	52	4	9ad844d9d5aac39d133ae8ab9c4839300f08064c
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|GI_small-bowel / Manually curated celltypes from each tissue	EEF2 TNFRSF9 ENTPD1 SOD1	8.03e-05	196	52	4	5755ca4abcae3717894bbf7cbd49bca0a3a03067
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EEF2 DNAJA2 ATP1A1 HNRNPK	8.03e-05	196	52	4	151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo\|GI_small-bowel / Manually curated celltypes from each tissue	EEF2 TNFRSF9 ENTPD1 SOD1	8.03e-05	196	52	4	181f3c1af565355b29f20ca6074147c313ca3477
ToppCell	mLN-T_cell-Treg\|T_cell / Region, Cell class and subclass	TNFRSF9 ENTPD1 INPP5F SOD1	8.19e-05	197	52	4	3779489d57ebda33277c79cba037f4c73128c8ba
ToppCell	(1)_T_cell-(15)_Treg\|(1)_T_cell / shred on Cell_type and subtype	TNFRSF9 ZC2HC1A ENTPD1 SOD1	8.19e-05	197	52	4	6e7723e8b977be35c60cc11ac7cfa4f71339441e
ToppCell	Transverse-T_cell-Treg\|T_cell / Region, Cell class and subclass	TNFRSF9 ZC2HC1A ENTPD1 SOD1	8.19e-05	197	52	4	b7a1637e4baadd657f6279f4aa96cd590c9cd8c9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EEF2 ATP1A1 HNRNPK SOD1	8.19e-05	197	52	4	02cc9d39afefa5e5b6f5d93f9adc3a20050b70dd
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNFRSF9 ZC2HC1A ENTPD1 INPP5F	8.19e-05	197	52	4	54fb7197db3c0dc87a1114e1ab1d2bfafd564b35
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNFRSF9 ZC2HC1A ENTPD1 INPP5F	8.35e-05	198	52	4	03423d6c614440b9c738f75ac3f5a6941719a279
ToppCell	COVID-19-Heart-Mito_CM\|Heart / Disease (COVID-19 only), tissue and cell type	EEF2 IDH2 MDH2 SOD1	8.35e-05	198	52	4	b6cd439863d17209b86dc50ae51282dc1725955d
ToppCell	severe-Treg\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EEF2 TNFRSF9 ZC2HC1A SOD1	8.35e-05	198	52	4	377980b9f7d02818e1d145e6884604f8bfacc4f2
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTHFD1 NCAPD2 HAT1 TMEM121	8.35e-05	198	52	4	c78ff8fc71dfcba1ac0c373bc90ea7b87c5699a4
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNFRSF9 ZC2HC1A ENTPD1 RBKS	8.35e-05	198	52	4	d021d0edb6aba2f15c51a3ec4e08c7233d0c1962
ToppCell	Transverse-T_cell-gd_T\|T_cell / Region, Cell class and subclass	TNFRSF9 ENTPD1 TRPM2 RBKS	8.51e-05	199	52	4	8baea162803cea7d72dff5866a0eebfcf2e5dcd6
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BOC AEBP1 SH3D19 KIAA1755	8.68e-05	200	52	4	0b2614b8513693dd508c9003699049efd9abac52
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Cortical_neuron\|5w / Sample Type, Dataset, Time_group, and Cell type.	RELN ZC2HC1A ZFHX3 ATP1A3	8.68e-05	200	52	4	085060d148158f7d9e938b6c4a3700ccbb3bca15
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	BOC AEBP1 SH3D19 KIAA1755	8.68e-05	200	52	4	8d2ceb2080c67b20f452eeca605aa27a58033c04
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Interneuron\|5w / Sample Type, Dataset, Time_group, and Cell type.	RELN ZC2HC1A ZFHX3 ATP1A3	8.68e-05	200	52	4	c7e33057466915d4e2b34f2062b22d9cdffa69dc
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal\|5w / Sample Type, Dataset, Time_group, and Cell type.	RELN ZC2HC1A ZFHX3 ATP1A3	8.68e-05	200	52	4	9b5753726c17dda98d7384a60f26a5eaf4f6c4d6
ToppCell	Parenchyma_COVID-19-Stromal-TX-Fibroblasts-2,_SCARA5\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	BOC AEBP1 SH3D19 KIAA1755	8.68e-05	200	52	4	c338a08c1605527ab9aaf62ea151a19e8469dc6d
ToppCell	droplet-Spleen-nan-21m-Hematologic-erythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN NT5C3A SH3D19	1.54e-04	89	52	3	e7d9498a1a3aa974fdd68b394c3eaff8e35c9727
ToppCell	BAL-Control-cDC_4\|Control / Compartment, Disease Groups and Clusters	ZFHX3 TMEM121 ABCC10	6.45e-04	145	52	3	3b2a2965dc18abd39d5ed70c0fcad0210e7f12c8
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PNPLA6 NT5C3A ATP1A1	6.45e-04	145	52	3	47a3bb973a508d3097213a2d86ad1ce697af9bae
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3C2B TEDDM1 TMEM121	6.45e-04	145	52	3	2eebf2294c53f081d3b0169071388e477a195218
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TNFRSF9 ZC2HC1A ENTPD1	7.40e-04	152	52	3	6d02b50e9e9ecf820f84a79e46d153a4840a1cfe
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TNFRSF9 ZC2HC1A ENTPD1	7.40e-04	152	52	3	eb7ff36792c3c54ac88cfe976f84016b70b1a1d7
ToppCell	(2)_NK/T-(23)_CD4+_T_cell-(230)_CD4+/CD25+_Reg_T_cell\|(23)_CD4+_T_cell / immune cells in Peripheral Blood (logTPM normalization)	TNFRSF9 ZC2HC1A ENTPD1	7.69e-04	154	52	3	059bdf6843f94f5028d4df6aa025865a9edb4521
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDCL2 WFDC12 LDHC	7.69e-04	154	52	3	c6f1a0806d492b1f01cded2daffaf3f13422deb6
ToppCell	normal_Lung-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	THNSL1 ENTPD1 PDCL2	7.69e-04	154	52	3	835ef49d314ecbcbfd8d1041ba202a5eedcda0bd
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TNFRSF9 ENTPD1 PIPOX	7.69e-04	154	52	3	9200e2f1783e54cbc5dfc3b485b57c761af74a46
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TNFRSF9 ENTPD1 PIPOX	7.69e-04	154	52	3	b16f3139ce50e70a6a2377b1da7d7877b4000ea1
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDCL2 WFDC12 LDHC	7.69e-04	154	52	3	665885d8aca168513ab7a65f70d52181c821eb78
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDCL2 WFDC12 LDHC	7.69e-04	154	52	3	3c64111e2ca1bb04ddd1ecb19938a307778ff7eb
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	BOC CACNB1 EIF2S3B	7.83e-04	155	52	3	335cd798afbaa0a3a3e1dc558a81cfa32da48983
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	BOC CACNB1 EIF2S3B	7.98e-04	156	52	3	fc8b8aef29d6d1c0f0c1d08280d8aaff8d30535e
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBXO10 ATP1A3 SBNO2	7.98e-04	156	52	3	d411116d54add2d4fe649a97ac54cb94c085312f
ToppCell	droplet-Liver-Npc-21m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB1 ATP1A3 SBNO2	8.13e-04	157	52	3	264b22d0ffc43049161843bb55d2eccbf5fca575
ToppCell	droplet-Liver-Npc-21m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB1 ATP1A3 SBNO2	8.13e-04	157	52	3	67945d37027be62c880d3072afa7ca7e97c76c20
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-AT1_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRPM2 PLCG1 ABCC10	8.13e-04	157	52	3	a93866f051472506f1468f379c0d5313e02c9731
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN PLCG1 INPP5F	8.13e-04	157	52	3	a426c54fd1545093d41426e9620862f71bd06f6b
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D122\|Adult / Lineage, Cell type, age group and donor	BOC AEBP1 KIAA1755	8.28e-04	158	52	3	410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCell	facs-Heart-LV-24m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNFRSF9 PDCL2 WFDC12	8.28e-04	158	52	3	12a82230c01de552f12977634c304626e1cd6903
ToppCell	facs-Heart-LV-24m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNFRSF9 PDCL2 WFDC12	8.28e-04	158	52	3	bd432ecd2524656804e7c2775250e27db7906b70
ToppCell	facs-Heart-LA-24m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EEF2 WFDC12 LDHC	8.74e-04	161	52	3	248487415a0601d57ef2a6692e22a61368d0b9c8
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TNFRSF9 ZC2HC1A ENTPD1	9.06e-04	163	52	3	bca9abd02ffb2a90c8386a59f5e25126ae7b6acd
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TNFRSF9 PARD3B TAC3	9.06e-04	163	52	3	39181c58387189a815e7b3eb29fbd1dd4ee24d0a
ToppCell	facs-SCAT-Fat-24m-Epithelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDCL2 WFDC12 LDHC	9.06e-04	163	52	3	9fd2e495efb6c447cdc52efdb3b695cb2fa8b914
ToppCell	facs-SCAT-Fat-24m-Epithelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDCL2 WFDC12 LDHC	9.06e-04	163	52	3	ade2f59bca0ab0c4856202f980464f3287bddd24
ToppCell	10x5'-Lung-Lymphocytic_T_CD8-Tnaive/CM_CD8\|Lung / Manually curated celltypes from each tissue	ZNF594 PARD3B PLCG1	9.06e-04	163	52	3	c8e4440d1a857e4da83002303940dd42b273c92e
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-T_cells-TRGV4_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TNFRSF9 ENTPD1 RBKS	9.06e-04	163	52	3	11cc18f36604d9a5f4e7fb8626a8f0fb141da5e1
ToppCell	facs-SCAT-Fat-24m-Epithelial-epithelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDCL2 WFDC12 LDHC	9.06e-04	163	52	3	aaf5d96bab1957c7bde84c741c7f2fb86ef41e8b
ToppCell	facs-Skin-nan-24m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC WFDC3 FBXO2	9.22e-04	164	52	3	7a65c7a6dbe5fb9067f83efafbb7ec8206d79325
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TNFRSF9 ZC2HC1A PLCG1	9.38e-04	165	52	3	dbe231d00843cae917efd1abea6079ace3b45cdf
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TNFRSF9 ZC2HC1A PLCG1	9.38e-04	165	52	3	9ccce713d4122054bf4bef4a7126d90cf9141b84
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-TRGV4_gdT\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ENTPD1 FBXO2 SBNO2	9.38e-04	165	52	3	9f6f3a614ac614488e9f59cf2805467ff075ccca
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-BM_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNFRSF9 THNSL1 SH3D19	9.55e-04	166	52	3	aa2df07eff323ded751ced8938af08223d7f2029
ToppCell	facs-BAT-Fat-24m-Myeloid\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDCL2 WFDC12 LDHC	9.55e-04	166	52	3	001a31aaa4ab4d5606b894faf6fcaad524405064
ToppCell	facs-BAT-Fat-24m-Myeloid-myeloid_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDCL2 WFDC12 LDHC	9.55e-04	166	52	3	31ed1290b4a977eabfc29674a5c593985bff6a74
ToppCell	facs-BAT-Fat-24m-Myeloid-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDCL2 WFDC12 LDHC	9.55e-04	166	52	3	c71ad3fc6a14507609d17756431d3deff9fda418
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WFDC3 PIPOX CNTN6	9.55e-04	166	52	3	c11dcf9705b85ac3da6ae86358f5ffd64ae8327e
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNFRSF9 THNSL1 SH3D19	9.55e-04	166	52	3	695298a94d62b8adab083900003ec636fbaae5d9
ToppCell	facs-Heart-LV-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 WFDC12 LDHC	9.55e-04	166	52	3	c02c2a68d61dbd7ed086d9b02cfcb1778b8a8656
ToppCell	facs-Heart-LV-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 WFDC12 LDHC	9.55e-04	166	52	3	20c24a9d2eb67a20e5154d25656da14186034f02
ToppCell	droplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB1 PLCG1 ABCC10	9.71e-04	167	52	3	bad33497ceeab968a7eb8a48b921c6f936390743
ToppCell	COVID-19_Moderate-Treg\|COVID-19_Moderate / disease group, cell group and cell class	TNFRSF9 ZC2HC1A SOD1	9.71e-04	167	52	3	4ddb21421cbe72c06b61dd3a5eb1337e59de42e5
ToppCell	droplet-Lung-18m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NT5C3A WFDC12 LDHC	9.88e-04	168	52	3	0e99ecd94ab8e5372e30433d7d0aa76b4d54257a
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRPM2 ATP1A3 SBNO2	9.88e-04	168	52	3	27cdf5cfa1d906868cfd60fdfab3cd51f3b3602f
ToppCell	3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TNFRSF9 PIK3C2B PARD3B	9.88e-04	168	52	3	55f328353119cbdc521c782ebb8d163876f4186d
ToppCell	droplet-Lung-18m-Hematologic-myeloid-Basophil/Mast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NT5C3A WFDC12 LDHC	9.88e-04	168	52	3	34722e14f28313f2e4644b3c1861ef12958cee9f
ToppCell	droplet-Lung-nan-18m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NT5C3A WFDC12 LDHC	1.01e-03	169	52	3	f2e20049a17eee533d49bd5f24a51962d123d132
Computational	Genes in the cancer module 286	IDH2 MDH2 LDHC	1.58e-04	37	31	3	MODULE_286
Drug	arabinosyladenine	BOC PIK3C2B NT5C3A ENTPD1 RBKS TAC3 IDH2 HARS1 ATP1A1 ATP1A3 MDH2 LDHC	8.67e-08	762	51	12	CID000000191
Drug	bromfenacoum	RELN EEF2 ZC2HC1A MTHFD1 PLCG1 HARS1 ATP1A3 MDH2 HNRNPK SOD1	1.37e-06	644	51	10	ctd:C013418
Drug	NaCl	PNPLA6 PIK3C2B TAC3 HARS1 ATP1A1 ATP1A3 MDH2 LDHC SOD1	3.97e-06	564	51	9	CID000005234
Drug	NSC-7616	UBR5 IDH2 MDH2 LDHC	4.77e-06	50	51	4	CID000000309
Drug	nsc25485	BOC PIK3C2B NT5C3A ENTPD1 PLCG1 ATP1A1 ATP1A3	5.86e-06	312	51	7	CID000004605
Drug	glutamate	CACNB1 RELN EEF2 MTHFD1 TRPM2 TAC3 PLCG1 IDH2 MDH2 LDHC SOD1	7.30e-06	962	51	11	CID000000611
Drug	AC1O54Y4	IDH2 MDH2 LDHC SOD1	1.37e-05	65	51	4	CID006452212
Drug	AC1L2506	IDH2 MDH2	1.47e-05	3	51	2	CID000066271
Drug	pyridine	BOC EEF2 PDCL2 IDH2 MDH2 LDHC	1.52e-05	239	51	6	CID000001049
Drug	T-2 Toxin	RELN EEF2 RBKS ATP1A1 HNRNPK SOD1 FBXO2	1.54e-05	362	51	7	ctd:D013605
Drug	hydroxymalonate	IDH2 MDH2 LDHC	1.82e-05	23	51	3	CID000000044
Drug	AC1L1D5O	BOC PIPOX MDH2 LDHC SOD1	2.28e-05	152	51	5	CID000002204
Drug	carnitine	BOC PIPOX IDH2 MDH2 LDHC SOD1	2.73e-05	265	51	6	CID000000085
Drug	magnesium	EEF2 MTHFD1 NT5C3A ENTPD1 RBKS IDH2 INPP5F ATP1A1 ATP1A3 MDH2 LDHC SOD1	2.74e-05	1325	51	12	CID000000888
Drug	genistein	CACNB1 EEF2 PIK3C2B MTHFD1 NT5C3A NCAPD2 PLCG1 ITGAV ABCC10 HNRNPK SOD1	2.94e-05	1117	51	11	CID005280961
Drug	fluorocitrate	UBR5 IDH2 MDH2	2.98e-05	27	51	3	CID000107647
Drug	formate	BOC UBR5 MTHFD1 MDH2 LDHC SOD1	3.09e-05	271	51	6	CID000000283
Drug	U46619	CACNB1 ENTPD1 TAC3 PLCG1 LDHC SOD1	4.10e-05	285	51	6	CID000005618
Drug	isofenphos	PNPLA6 LDHC SOD1	4.55e-05	31	51	3	CID000032872
Drug	22,23-dihydrobufalin	ATP1A1 ATP1A3	4.90e-05	5	51	2	CID000195392
Drug	3-acetylstrophanthin	ATP1A1 ATP1A3	4.90e-05	5	51	2	CID003082282
Drug	butanesulfonate	IDH2 MDH2	4.90e-05	5	51	2	CID000049935
Drug	thevetin A	ATP1A1 ATP1A3	4.90e-05	5	51	2	CID000441873
Drug	alphaNMN	NT5C3A PIPOX IDH2 LDHC	4.95e-05	90	51	4	CID000000939
Drug	butandiol	BOC UBR5 LDHC	5.02e-05	32	51	3	CID000165788
Drug	acetate	BOC MTHFD1 PIPOX HAT1 IDH2 MDH2 LDHC SOD1	5.14e-05	599	51	8	CID000000175
Drug	aluminum	RELN PLCG1 IDH2 ATP1A1 SOD1	5.67e-05	184	51	5	CID000104727
Drug	S-allyl-L-cysteine	IDH2 LDHC SOD1	7.18e-05	36	51	3	CID000098280
Drug	N-methylhydantoin	PIPOX IDH2	7.34e-05	6	51	2	CID000069217
Drug	ETH157	ATP1A1 ATP1A3	7.34e-05	6	51	2	CID000563154
Drug	Haloperidol [52-86-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A	CACNB1 RELN TNFRSF9 IPO13 TAC3	7.84e-05	197	51	5	5638_UP
Drug	chloride	BOC HAT1 TAC3 PDCL2 ATP1A1 ATP1A3 MDH2 LDHC SOD1 FBXO2	8.02e-05	1029	51	10	CID000000312
Drug	Mephenytoin [50-12-4]; Up 200; 18.4uM; MCF7; HT_HG-U133A	CACNB1 PNPLA6 ENTPD1 TRPM2 SBNO2	8.03e-05	198	51	5	6275_UP
Drug	lead nitrate	TRPM2 ZFHX3 ATP1A1 LDHC SOD1	9.90e-05	207	51	5	ctd:C017461
Drug	Metazamide	IDH2 MDH2	1.03e-04	7	51	2	CID000026433
Drug	dihydrodigitoxigenin	ATP1A1 ATP1A3	1.03e-04	7	51	2	CID000107549
Drug	reduced diphosphopyridine nucleotide	MTHFD1 PIPOX IDH2 MDH2 LDHC SOD1	1.12e-04	342	51	6	CID000000928
Drug	NSC20257	BOC EEF2 NT5C3A ENTPD1 HARS1	1.13e-04	213	51	5	CID000001172
Drug	3-phosphoglycerate	MTHFD1 IDH2 MDH2 LDHC	1.24e-04	114	51	4	CID000000724
Drug	alpha-methyl-D-mannoside	BOC IDH2 ATP1A1 ATP1A3	1.33e-04	116	51	4	CID000002108
Drug	adenine	MTHFD1 NT5C3A ENTPD1 RBKS IDH2 MDH2 LDHC	1.34e-04	510	51	7	CID000000190
Drug	S-(1,2-dichlorovinyl)-L-homocysteine	IDH2 MDH2	1.37e-04	8	51	2	CID006437876
Drug	O-acetyltyrosine	BOC TAC3	1.37e-04	8	51	2	CID000226267
Drug	Ouabain	ZFHX3 ATP1A1 ATP1A3 MDH2	1.47e-04	119	51	4	ctd:D010042
Drug	NiCl2	PDCL2 IDH2 MDH2 LDHC	1.47e-04	119	51	4	CID000024385
Drug	hydroxyl radicals	BOC EEF2 MTHFD1 NT5C3A ENTPD1 PIPOX PLCG1 ATP1A1 ATP1A3 MDH2 SOD1	1.52e-04	1341	51	11	CID000000961
Drug	D-ribofuranose	EEF2 RBKS IDH2 MDH2 LDHC	1.56e-04	228	51	5	CID000000854
Drug	AC1L4B0X	IDH2 MDH2 LDHC SOD1	1.61e-04	122	51	4	CID000153769
Drug	AC1MBZB6	ATP1A1 ATP1A3	1.75e-04	9	51	2	CID002733620
Drug	2-butenedioate	UBR5 IDH2 MDH2 LDHC HNRNPK	1.76e-04	234	51	5	CID000000723
Drug	AC1L9785	IDH2 MDH2 SOD1	1.81e-04	49	51	3	CID000439374
Drug	silver nitrate	BOC PDCL2 LDHC	1.81e-04	49	51	3	CID000024470
Drug	CO(2	BOC MTHFD1 PIPOX IDH2 MDH2 LDHC	1.93e-04	378	51	6	CID000000280
Drug	mercury	BOC CACNB1 PIK3C2B PLCG1 LDHC ABCC10 SOD1	1.95e-04	542	51	7	CID000023931
Drug	limonene	DNAJA2 ATP1A1 SOD1	2.17e-04	52	51	3	ctd:C008281
Drug	nickel	CACNB1 UBR5 NT5C3A PLCG1 PDCL2 SOD1 FBXO2	2.18e-04	552	51	7	CID000000934
Drug	8-bromoadenine	IDH2 MDH2	2.19e-04	10	51	2	CID000081457
Drug	mivazerol	BOC LDHC	2.19e-04	10	51	2	CID000060783
Drug	prostacyclin sodium salt	BOC UBR5 ENTPD1 TAC3 SOD1	2.39e-04	250	51	5	CID000000159
Drug	H2O2	PIK3C2B TRPM2 PIPOX PLCG1 IDH2 ATP1A1 ATP1A3 MDH2 LDHC SOD1	2.51e-04	1183	51	10	CID000000784
Drug	DMTU	TAC3 LDHC SOD1	2.56e-04	55	51	3	CID002723631
Drug	K-Cl	RELN EEF2 IDH2 ATP1A1 ATP1A3 MDH2 LDHC	2.56e-04	567	51	7	CID000004873
Drug	butylmalonate	IDH2 MDH2	2.67e-04	11	51	2	CID000010801
Drug	Calix[4]arene	BOC PDCL2	2.67e-04	11	51	2	CID000562409
Drug	26 d	BOC PDCL2	2.67e-04	11	51	2	CID000008861
Drug	benzyl chloride	BOC PDCL2	2.67e-04	11	51	2	CID000007503
Drug	ouabagenin	ATP1A1 ATP1A3	2.67e-04	11	51	2	CID000010497
Drug	NSC-312017	BOC PDCL2	2.67e-04	11	51	2	CID000432667
Drug	Xanthine	IDH2 MDH2 SOD1	2.84e-04	57	51	3	ctd:D019820
Drug	AMP group	EEF2 NT5C3A ENTPD1 TRPM2 HARS1 MDH2 LDHC	2.91e-04	579	51	7	CID000000224
Drug	dimethylformamide	BOC PDCL2 SOD1	3.00e-04	58	51	3	CID000006228
Drug	2-isopropylmalate	IDH2 SOD1	3.20e-04	12	51	2	CID000000036
Drug	trifluoro-methyl	BOC PNPLA6 PDCL2	3.31e-04	60	51	3	CID000137518
Drug	alanine	BOC PIPOX IDH2 MDH2 LDHC	3.34e-04	269	51	5	CID000000602
Drug	coenzyme 1	EEF2 MTHFD1 TRPM2 PIPOX IDH2 MDH2 LDHC	3.47e-04	596	51	7	CID000000925
Drug	manganese	CACNB1 PIPOX IDH2 INPP5F MDH2 ITGAV LDHC SOD1	3.47e-04	791	51	8	CID000023930
Disease	Bipolar Disorder	RELN MTHFD1 TRPM2 PLCG1 ATP1A1 ATP1A3 CNTN6	1.51e-05	477	50	7	C0005586
Disease	Anterior Horn Cell Disease	PNPLA6 SOD1	1.68e-05	4	50	2	C0154681
Disease	Motor Neuron Disease, Upper	PNPLA6 SOD1	1.68e-05	4	50	2	C0521659
Disease	Motor Neuron Disease, Secondary	PNPLA6 SOD1	1.68e-05	4	50	2	C0543858
Disease	Motor Neuron Disease	PNPLA6 SOD1	1.68e-05	4	50	2	C0085084
Disease	Familial Motor Neuron Disease	PNPLA6 SOD1	1.68e-05	4	50	2	C0270763
Disease	Motor Neuron Disease, Lower	PNPLA6 SOD1	1.68e-05	4	50	2	C0270764
Disease	Lateral Sclerosis	PNPLA6 SOD1	2.80e-05	5	50	2	C0154682
Disease	Down syndrome (is_implicated_in)	MTHFD1 SOD1	4.20e-05	6	50	2	DOID:14250 (is_implicated_in)
Disease	familial hemiplegic migraine (implicated_via_orthology)	ATP1A1 ATP1A3	5.88e-05	7	50	2	DOID:0060178 (implicated_via_orthology)
Disease	Acute Cerebrovascular Accidents	ZFHX3 ITGAV SOD1	1.07e-04	54	50	3	C0751956
Disease	colorectal cancer (is_marker_for)	EEF2 ZFHX3 PLCG1 HNRNPK	1.47e-04	157	50	4	DOID:9256 (is_marker_for)
Disease	Cerebrovascular accident	ZFHX3 ITGAV SOD1	1.61e-04	62	50	3	C0038454
Disease	nervous system disease (implicated_via_orthology)	ATP1A1 ATP1A3	1.84e-04	12	50	2	DOID:863 (implicated_via_orthology)
Disease	hypothyroidism (biomarker_via_orthology)	RELN ENTPD1 SOD1	3.43e-04	80	50	3	DOID:1459 (biomarker_via_orthology)
Disease	lung adenocarcinoma (is_marker_for)	EEF2 PLCG1 IDH2	4.10e-04	85	50	3	DOID:3910 (is_marker_for)
Disease	Degenerative polyarthritis	EEF2 IDH2 ATP1A3	5.34e-04	93	50	3	C0029408
Disease	Osteoarthrosis Deformans	EEF2 IDH2 ATP1A3	5.34e-04	93	50	3	C0086743
Disease	Down syndrome (is_marker_for)	RELN MTHFD1	6.36e-04	22	50	2	DOID:14250 (is_marker_for)
Disease	calcium measurement	ZFHX3 PDCL2 ATP1A1 ATP1A3 TMEM121 ABCC10	6.51e-04	628	50	6	EFO_0004838
Disease	low density lipoprotein cholesterol measurement, response to escitalopram, response to citalopram	RELN ZFHX3	7.58e-04	24	50	2	EFO_0004611, EFO_0006329, EFO_0007871
Disease	severe acute respiratory syndrome, COVID-19	RELN FBXO10 TRPM2 ZFHX3 CNTN6	9.43e-04	447	50	5	EFO_0000694, MONDO_0100096
Disease	Alzheimer's disease (is_marker_for)	RELN EEF2 PLCG1 SOD1	9.45e-04	257	50	4	DOID:10652 (is_marker_for)
Disease	Ventricular Dysfunction, Left	IDH2 ATP1A3	1.19e-03	30	50	2	C0242698

Protein segments in the cluster

Peptide	Gene	Start	Entry
TRVEEIICGLIKGGA	NT5C3A	66	Q9H0P0
IGRLVKEGCEVGFIP	CACNB1	146	Q02641
RGIKGVVTDEQGIPI	AEBP1	906	Q8IUX7
VPVEIVGQGKLGEVA	FBXO10	151	Q9UK96
KRGCQVVIITLGAEG	RBKS	226	Q9H477
VTFCVQPGEKLGIVG	ABCC10	1266	Q5T3U5
GIVVPCKEGQLRVGE	PARD3B	11	Q8TEW8
GPDGKECVVKEVVPG	PNPLA6	246	Q8IY17
PGLIKVEQARCGEVA	KIAA1755	246	Q5JYT7
KGCDVVVIPAGVPRK	MDH2	91	P40926
VVGDLVEVKGGDRIP	ATP1A1	186	P05023
GQGLVPVVECVVDGQ	ATXN1L	296	P0C7T5
KCQQEGLVPEGGVEE	FBXO2	91	Q9UK22
QIEAKFIGIIECGGI	PDCL2	171	Q8N4E4
IPCVLGRNGVSDVVK	LDHC	291	P07864
GVVHQVEECRVKGPG	ENTPD1	76	P49961
VIGGEIVKPEQGCGV	RELN	1086	P78509
VDPLGENIRVIFKCG	PIK3C2B	1071	O00750
GKVIEPGCVRVVRGE	DNAJA2	301	O60884
NILGGTVFREPIICK	IDH2	141	P48735
DVEGKIRQIIPPGFC	HAT1	106	O14929
VQKPGGTVILGCVVE	BOC	46	Q9BWV1
TQPGIVEGGQVLKCD	ITGAV	76	P06756
VQVGGDIVIGCKPNA	CNTN6	421	Q9UQ52
VVGDLVEIKGGDRVP	ATP1A3	176	P13637
IEDVPCGNIVGLVGV	EEF2	461	P13639
GVLKVGQETEVRPGI	EIF2S3B	286	Q2VIR3
NPICLGLVEGVIGKI	INPP5F	41	Q9Y2H2
KVPCVGLSIGVERIF	HARS1	376	P12081
PRCGEVESVGKVVQE	IPO13	846	O94829
GCLELIKETGVPIAG	MTHFD1	151	P11586
VIIDIPEGGNGKREC	SH3D19	551	Q5HYK7
VLPQRCVGLEKGTLV	TEDDM1	91	Q5T9Z0
RVVLIGGKPDRVVEC	HNRNPK	191	P61978
GEVLGVIGDCPELVQ	POGZ	1306	Q7Z3K3
GIKIPEGCVRRVLQE	SBNO2	1206	Q9Y2G9
VCVLKGDGPVQGIIN	SOD1	6	P00441
GEIVREIGQKCPQEL	NCAPD2	276	Q15021
RGGDCPKVLVGLCIV	WFDC3	166	Q8IUB2
VEGVKEGIEKAGVCP	WFDC12	21	Q8WWY7
IKIPIVCVVLEGGPG	TRPM2	321	O94759
EQNQGPRKIGVCIIV	TMEM121	31	Q9BTD3
VLVNGTKERDVVCGP	TNFRSF9	146	Q07011
PKNGRGIVCPFVEIE	PLCG1	1101	P19174
VGRIIGQKLGCCVID	THNSL1	71	Q8IYQ7
ENGGVVQVGELLPCK	ZC2HC1A	6	Q96GY0
IIPQKAIVGEIGHGC	ZNF594	71	Q96JF6
GGIVRDGEKVVEINP	PIPOX	166	Q9P0Z9
AVCKEPQEEVVPGGG	TAC3	21	Q9UHF0
LCKEEGGGQVELIPN	UBR5	2606	O95071
CEVLGNDIGLPKRVV	ZFHX3	2976	Q15911
LREVCPVQEIDGKAG	ZSCAN23	176	Q3MJ62