Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionalpha-amylase activity

AMY1A AMY1B AMY1C AMY2A AMY2B

1.27e-155235GO:0004556
GeneOntologyMolecularFunctionamylase activity

AMY1A AMY1B AMY1C AMY2A AMY2B

7.63e-156235GO:0016160
GeneOntologyMolecularFunctionchloride ion binding

AMY1A AMY1B AMY1C AMY2A AMY2B

5.51e-1216235GO:0031404
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing O-glycosyl compounds

AMY1A AMY1B AMY1C AMY2A AMY2B

1.03e-07103235GO:0004553
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

AMY1A AMY1B AMY1C AMY2A AMY2B

5.51e-07144235GO:0016798
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

DUX4L2 DUX4 DUX5 DUX1 DUXA LHX8 SNAPC4 DUX4L4 DUX4L9

1.85e-051459239GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

DUX4L2 DUX4 DUX5 DUX1 DUXA LHX8 DUX4L4 DUX4L9

1.15e-041412238GO:0000981
GeneOntologyMolecularFunctioncalcium ion binding

AMY1A AMY1B AMY1C AMY2A AMY2B

1.40e-03749235GO:0005509
GeneOntologyBiologicalProcessoligosaccharide metabolic process

AMY1A AMY1B AMY1C

5.50e-0570223GO:0009311
MousePhenoincreased basal metabolism

GNAS TBC1D1

1.38e-042892MP:0008965
MousePhenoabnormal basal metabolism

GNAS TBC1D1

3.92e-044792MP:0008961
MousePhenoincreased white adipose tissue amount

GNAS TBC1D1

4.81e-045292MP:0000008
MousePhenoneonatal lethality, incomplete penetrance

GNAS LHX8 RTL1

7.32e-0429893MP:0011088
MousePhenoabnormal muscle cell glucose uptake

GNAS TBC1D1

7.97e-046792MP:0004130
DomainAamy_C

AMY1A AMY1C AMY2A AMY2B

7.65e-134194SM00632
DomainAlpha_amylase

AMY1A AMY1C AMY2A AMY2B

7.65e-134194IPR006046
DomainAlpha-amylase_C

AMY1A AMY1C AMY2A AMY2B

3.82e-125194PF02806
DomainA-amylase/branching_C

AMY1A AMY1C AMY2A AMY2B

3.82e-125194IPR006048
DomainGlyco_hydro_13_cat_dom

AMY1A AMY1C AMY2A AMY2B

2.67e-117194IPR006047
DomainAamy

AMY1A AMY1C AMY2A AMY2B

2.67e-117194SM00642
DomainAlpha-amylase

AMY1A AMY1C AMY2A AMY2B

2.67e-117194PF00128
DomainA-amylase_C

AMY1A AMY2A AMY2B

8.93e-103193IPR031319
DomainGlyco_hydro_b

AMY1A AMY1C AMY2A AMY2B

1.04e-0915194IPR013780
DomainGlyco_hydro_13

AMY1A AMY2A AMY2B

1.78e-086193IPR015902
DomainGlyco_hydro_catalytic_dom

AMY1A AMY1C AMY2A AMY2B

5.52e-0838194IPR013781
DomainGlycoside_hydrolase_SF

AMY1A AMY1C AMY2A AMY2B

2.17e-0753194IPR017853
Domain-

DUX4 DUX5 DUX1 DUXA LHX8 SNAPC4

2.64e-072831961.10.10.60
Domain-

AMY1A AMY2A AMY2B

3.23e-07141932.60.40.1180
DomainHTH_motif

DUX4 DUX5 DUX1 DUXA

6.34e-0769194IPR000047
DomainHomeodomain-like

DUX4 DUX5 DUX1 DUXA LHX8 SNAPC4

6.73e-07332196IPR009057
DomainHomeobox

DUX4 DUX5 DUX1 DUXA LHX8

2.98e-06234195PF00046
DomainHOX

DUX4 DUX5 DUX1 DUXA LHX8

3.17e-06237195SM00389
DomainHomeobox_dom

DUX4 DUX5 DUX1 DUXA LHX8

3.31e-06239195IPR001356
DomainHOMEOBOX_2

DUX4 DUX5 DUX1 DUXA LHX8

3.31e-06239195PS50071
Domain-

AMY1A AMY2A AMY2B

5.72e-06351933.20.20.80
DomainHOMEOBOX_1

DUX5 DUX1 DUXA LHX8

8.30e-05236194PS00027
DomainHomeobox_CS

DUX5 DUX1 LHX8

8.37e-04186193IPR017970
PathwayKEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION_AMYLASE_

AMY1A AMY1B AMY1C AMY2A AMY2B

1.18e-139165M47622
PathwayREACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE

AMY1A AMY1B AMY1C AMY2A AMY2B

4.34e-1311165M1091
PathwayREACTOME_DIGESTION

AMY1A AMY1B AMY1C AMY2A AMY2B

3.13e-1123165M27790
PathwayREACTOME_DIGESTION_AND_ABSORPTION

AMY1A AMY1B AMY1C AMY2A AMY2B

9.12e-1128165M27837
PathwayKEGG_STARCH_AND_SUCROSE_METABOLISM

AMY1A AMY1B AMY1C AMY2A AMY2B

2.37e-0952165M14171
PathwayREACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE

AMY1B AMY2A AMY2B

6.69e-088163MM14717
PathwayREACTOME_DIGESTION

AMY1B AMY2A AMY2B

1.58e-0621163MM15526
PathwayREACTOME_DIGESTION_AND_ABSORPTION

AMY1B AMY2A AMY2B

2.72e-0625163MM15557
PathwayREACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA

DUX4 DUXA

1.63e-0417162M48025
Pubmed

Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.

DUX4L2 DUX4 DUX5 DUX1 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

5.54e-251727911245978
Pubmed

Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7 DUX4L9

2.07e-231227810433963
Pubmed

Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7 DUX4L9

5.37e-231327817668377
Pubmed

The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

5.82e-22827717588759
Pubmed

DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

8.72e-211027717984056
Pubmed

Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

1.24e-19132777739628
Pubmed

Concerted evolution of human amylase genes.

AMY1A AMY1B AMY1C AMY2A AMY2B

1.14e-1562752452973
Pubmed

Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1.

AMY1A AMY1B AMY1C AMY2A AMY2B

1.14e-1562756608795
Pubmed

The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes.

AMY1A AMY1B AMY1C AMY2A AMY2B

1.14e-1562752788608
Pubmed

Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers.

AMY1A AMY1B AMY1C AMY2A AMY2B

1.14e-1562752081604
Pubmed

Detection of large-scale variation in the human genome.

AMY1A AMY1B AMY1C AMY2A AMY2B

1.14e-15627515286789
Pubmed

AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex.

AMY1A AMY1B AMY1C AMY2A AMY2B

1.06e-14827512414807
Pubmed

The mouse alpha-amylase multigene family. Sequence organization of members expressed in the pancreas, salivary gland and liver.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342746176715
Pubmed

Low Copy Number of the AMY1 Locus Is Associated with Early-Onset Female Obesity in Finland.

AMY1B AMY1C AMY2A AMY2B

2.88e-13427426132294
Pubmed

Mouse liver and salivary gland alpha-amylase mRNAs differ only in 5' non-translated sequences.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342746162108
Pubmed

Characterization of the amino termini of mouse salivary and pancreatic amylases.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342746165618
Pubmed

Multiple polyadenylation sites in a mouse alpha-amylase gene.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342746166922
Pubmed

A single mouse alpha-amylase gene specifies two different tissue-specific mRNAs.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342746162570
Pubmed

Additional evidence for the close linkage of amy-1 and amy-2 in the mouse.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342746163812
Pubmed

Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity.

AMY1B AMY1C AMY2A AMY2B

2.88e-13427426098870
Pubmed

Simultaneous expression of salivary and pancreatic amylase genes in cultured mouse hepatoma cells.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342742431276
Pubmed

Multiple structural genes for mouse amylase.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342746160849
Pubmed

On the genetic polymorphism of the serum alpha-amylase in the population of the south western Bulgaria (second communication).

AMY1A AMY1B AMY2A AMY2B

2.88e-13427416152770
Pubmed

Members of the Amy-2 alpha-amylase gene family of mouse strain CE/J contain duplicated 5' termini.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342742987507
Pubmed

Independent regulation of nonallelic pancreatic amylase genes in diabetic mice.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342746207174
Pubmed

Electrophoretic variation of alpha-amylase in two inbred strains of Mus musculus.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342744745489
Pubmed

Termination of transcription in the mouse alpha-amylase gene Amy-2a occurs at multiple sites downstream of the polyadenylation site.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342746091898
Pubmed

Primary structure of human salivary alpha-amylase gene.

AMY1A AMY1B AMY1C AMY2A

2.88e-1342742423416
Pubmed

Gentic polymorphism of amylase isoenzymes in feral populations of the house mouse.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342741141004
Pubmed

Genetic variation in mouse salivary amylase rate of synthesis.

AMY1B AMY1C AMY2A AMY2B

2.88e-13427494264
Pubmed

Genetic regulation of GM4(NeuAc) expression in mouse erythrocytes.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342742332419
Pubmed

A 78-kilobase region of mouse chromosome 3 contains salivary and pancreatic amylase genes and a pseudogene.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342742410924
Pubmed

A salivary amylase transgene is efficiently expressed in liver but not in parotid gland of transgenic mice.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342742476716
Pubmed

Genetic determination of amylase synthesis in the mouse.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342746161122
Pubmed

Expression of mouse Amy-2a alpha-amylase genes is regulated by strong pancreas-specific promoters.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342743877171
Pubmed

The two promoters of the mouse alpha-amylase gene Amy-1a are differentially activated during parotid gland differentiation.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342743872721
Pubmed

Mouse alpha-amylase loci, Amy-1a and Amy-2a, are closely linked.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342742989529
Pubmed

Tissue-specific expression of mouse-alpha-amylase genes: nucleotide sequence of isoenzyme mRNAs from pancreas and salivary gland.

AMY1B AMY1C AMY2A AMY2B

2.88e-1342746157477
Pubmed

Structure of the murine tissue factor gene. Chromosome location and conservation of regulatory elements in the promoter.

AMY1B AMY1C AMY2A AMY2B

1.44e-1252741348427
Pubmed

Genetic mapping of the IL-12 alpha chain gene (Il12a) on mouse chromosome 3.

AMY1B AMY1C AMY2A AMY2B

1.44e-1252748661735
Pubmed

Esterase-26 (ES-26): characterization and genetic location on chromosome 3 of an eserine-sensitive esterase of the house mouse (Mus musculus).

AMY1B AMY1C AMY2A AMY2B

1.44e-1252746529441
Pubmed

Murine Salivary Amylase Protects Against Streptococcus mutans-Induced Caries.

AMY1B AMY1C AMY2A AMY2B

1.44e-12527434276419
Pubmed

Altered salivary amylase gene in the mouse strain BXD-16.

AMY1B AMY1C AMY2A AMY2B

1.44e-1252746176569
Pubmed

The spastic mouse: aberrant splicing of glycine receptor beta subunit mRNA caused by intronic insertion of L1 element.

AMY1B AMY1C AMY2A AMY2B

4.31e-1262747946325
Pubmed

Expression of calcyclin, a calcium-binding protein, in the keratogenous region of growing hair follicles.

AMY1B AMY1C AMY2A AMY2B

4.31e-1262742002257
Pubmed

Ampd-2 maps to distal mouse chromosome 3 in linkage with Ampd-1.

AMY1B AMY1C AMY2A AMY2B

4.31e-1262742328996
Pubmed

An unmethylated 3' promoter-proximal region is required for efficient transcription initiation.

AMY1B AMY2A AMY2B GNAS

4.31e-12627417305432
Pubmed

Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3.

AMY1B AMY1C AMY2A AMY2B

4.31e-1262742450406
Pubmed

Genetics of hydroxyacid oxidase isozymes in the mouse: localisation of Hao-2 on linkage group XVI.

AMY1B AMY1C AMY2A AMY2B

4.31e-126274284003
Pubmed

The mouse urate oxidase gene, Uox, maps to distal chromosome 3.

AMY1B AMY1C AMY2A AMY2B

4.31e-1262749250879
Pubmed

A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis.

AMY1B AMY1C AMY2A AMY2B

4.31e-1262747859283
Pubmed

Linkage of the cadmium resistance locus to loci on mouse chromosome 12.

AMY1B AMY1C AMY2A AMY2B

4.31e-1262741021597
Pubmed

Structure and chromosomal location of the mouse medium-chain acyl-CoA dehydrogenase-encoding gene and its promoter.

AMY1B AMY1C AMY2A AMY2B

1.01e-1172748666240
Pubmed

Genetic mapping of the gene encoding guanylate cyclase-A/atrial natriuretic factor receptor (Npra) to mouse chromosome 3.

AMY1B AMY1C AMY2A AMY2B

1.01e-1172747949740
Pubmed

Assignment of LH XVI to chromosome 3 in the mouse.

AMY1B AMY1C AMY2A AMY2B

1.01e-1172746160178
Pubmed

Rostral cerebellar malformation, (rcm): a new recessive mutation on chromosome 3 of the mouse.

AMY1B AMY1C AMY2A AMY2B

1.01e-1172741401878
Pubmed

cDNA cloning, sequencing and chromosomal assignment of the gene for mouse complement factor I (C3b/C4b inactivator): identification of a species specific divergent segment in factor I.

AMY1B AMY1C AMY2A AMY2B

1.01e-1172748604219
Pubmed

Analysis of the mouse Amy locus in recombinant inbred mouse strains.

AMY1B AMY1C AMY2A AMY2B

1.01e-1172742451911
Pubmed

Murine VCAM-1. Molecular cloning, mapping, and analysis of a truncated form.

AMY1B AMY1C AMY2A AMY2B

2.01e-1182747523515
Pubmed

The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships.

AMY1B AMY1C AMY2A AMY2B

2.01e-1182742824476
Pubmed

Biochemical and genetic characterization of esterase-27 (ES-27), the major plasma cholinesterase of the house mouse (Mus musculus).

AMY1B AMY1C AMY2A AMY2B

2.01e-1182742040456
Pubmed

Linkage relationships among eleven biochemical loci in Peromyscus.

AMY1B AMY1C AMY2A AMY2B

2.01e-1182746200103
Pubmed

cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I).

AMY1B AMY1C AMY2A AMY2B

2.01e-1182743038891
Pubmed

The genes encoding gonadal and nongonadal forms of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are closely linked on mouse chromosome 3.

AMY1B AMY1C AMY2A AMY2B

2.01e-1182748486361
Pubmed

[Genetic analysis of interspecific crosses Mus musculus L. x Mus spretus Lataste: linkage of Adh-1 with Amy-1 on chromosome 3 and Es-14 with Mod-1 on chromosome 9].

AMY1B AMY1C AMY2A AMY2B

3.62e-11927493520
Pubmed

The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas.

AMY1B AMY1C AMY2A AMY2B

6.03e-11102749121556
Pubmed

Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors.

AMY1B AMY1C AMY2A AMY2B

6.03e-11102742897103
Pubmed

Mouse R-cadherin: expression during the organogenesis of pancreas and gastrointestinal tract.

AMY1B AMY1C AMY2A AMY2B

9.47e-11112747493641
Pubmed

Chromosomal locations of genes encoding 2',3' cyclic nucleotide 3'-phosphodiesterase and glial fibrillary acidic protein in the mouse.

AMY1B AMY1C AMY2A AMY2B

9.47e-11112742903254
Pubmed

The murine M-CSF gene is localized on chromosome 3.

AMY1B AMY1C AMY2A AMY2B

9.47e-11112742565740
Pubmed

A far-upstream (-70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration.

AMY1B AMY1C AMY2A AMY2B

9.47e-111127423449223
Pubmed

Four loci from human chromosome 1 are physically assigned to sheep chromosome 1p.

AMY1B AMY1C AMY2A AMY2B

9.47e-11112748589528
Pubmed

Molecular cloning, characterization, and genetic mapping of the cDNA coding for a novel secretory protein of mouse. Demonstration of alternative splicing in skin and cartilage.

AMY1B AMY1C AMY2A AMY2B

9.47e-11112747608209
Pubmed

Multilocus markers for mouse genome analysis: PCR amplification based on single primers of arbitrary nucleotide sequence.

AMY1B AMY1C AMY2A AMY2B

9.47e-11112741617215
Pubmed

Mapping of glutathione transferase (GST) genes in the rat.

AMY1B AMY1C AMY2A AMY2B

1.42e-10122748144363
Pubmed

Assignment of the mouse homologues of 6 loci from HSA1p to chromosomes 3 and 4.

AMY1B AMY1C AMY2A AMY2B

2.05e-10132747829080
Pubmed

Gene order in linkage group XVI of the house mouse.

AMY1B AMY1C AMY2A AMY2B

2.05e-1013274489953
Pubmed

Fim-1, Fim-2/c-fms, and Fim-3, three common integration sites of Friend murine leukemia virus in myeloblastic leukemias, map to mouse chromosomes 13, 18, and 3, respectively.

AMY1B AMY1C AMY2A AMY2B

2.87e-10142742902233
Pubmed

New murine polymorphisms detected by random amplified polymorphic DNA (RAPD) PCR and mapped by use of recombinant inbred strains.

AMY1B AMY1C AMY2A AMY2B

2.87e-10142747894156
Pubmed

Syntenic assignment of human chromosome 1 homologous loci in the bovine.

AMY1B AMY1C AMY2A AMY2B

2.87e-10142748001974
Pubmed

Salivary α-amylase copy number is not associated with weight trajectories and glycemic improvements following clinical weight loss: results from a 2-phase dietary intervention study.

AMY1A AMY1B AMY1C

4.17e-10327330982860
Pubmed

Structure of human salivary alpha-amylase at 1.6 A resolution: implications for its role in the oral cavity.

AMY1A AMY1B AMY1C

4.17e-10327315299664
Pubmed

Report of the Committee on the Genetic Constitution of Chromosome 1.

AMY1B AMY2A AMY2B

4.17e-1032736360562
Pubmed

AMY1 Gene Copy Number Correlates With Glucose Absorption and Visceral Fat Volume, but Not with Insulin Resistance.

AMY1A AMY1B AMY1C

4.17e-10327332697825
Pubmed

Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in major depressive disorder patients.

AMY1A AMY1B AMY1C

4.17e-10327322063648
Pubmed

The structure of two distinct pancreatic amylase genes in mouse strain YBR.

AMY1B AMY2A AMY2B

4.17e-1032732413838
Pubmed

Multiple non-allelic genes encoding pancreatic alpha-amylase of mouse are expressed in a strain-specific fashion.

AMY1B AMY2A AMY2B

4.17e-1032736098446
Pubmed

Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase.

AMY1A AMY1B AMY1C

4.17e-10327312527308
Pubmed

Evolution of the amylase multigene family. YBR/Ki mice express a pancreatic amylase gene which is silent in other strains.

AMY1B AMY2A AMY2B

4.17e-1032732414282
Pubmed

Tissue-specific and insulin-dependent expression of a pancreatic amylase gene in transgenic mice.

AMY1B AMY2A AMY2B

4.17e-1032732436036
Pubmed

Regulation of amylase gene expression in diabetic mice is mediated by a cis-acting upstream element close to the pancreas-specific enhancer.

AMY1B AMY2A AMY2B

4.17e-1032731699843
Pubmed

Two distinct pancreatic amylase genes are active in YBR mice.

AMY1B AMY2A AMY2B

4.17e-1032736180955
Pubmed

Glucocorticoid receptor binding site in the mouse alpha-amylase 2 gene mediates response to the hormone.

AMY1B AMY2A AMY2B

4.17e-1032738413315
Pubmed

An insulin-responsive element in the pancreatic enhancer of the amylase gene.

AMY1B AMY2A AMY2B

4.17e-1032737678001
Pubmed

Salivary alpha amylase diurnal pattern and stress response are associated with body mass index in low-income preschool-aged children.

AMY1A AMY1B AMY1C

4.17e-10327325588701
Pubmed

Starch Digestion-Related Amylase Genetic Variant Affects 2-Year Changes in Adiposity in Response to Weight-Loss Diets: The POUNDS Lost Trial.

AMY1A AMY2A AMY2B

4.17e-10327328659346
Pubmed

Evidence of duplication of the human salivary amylase gene.

AMY1A AMY1B AMY1C

4.17e-1032736176528
Pubmed

Comparative genomic analysis of the mouse and rat amylase multigene family.

AMY1B AMY2A AMY2B

4.17e-10327317223109
Pubmed

State and trait variance in salivary α-amylase: a behavioral genetic study.

AMY1A AMY1B AMY1C

4.17e-10327321827821
Pubmed

A mouse linkage testing stock possessing multiple copies of the endogenous ecotropic murine leukemia virus genome.

AMY1B AMY1C AMY2A AMY2B

5.21e-10162742571572
InteractionAMY2B interactions

AMY1C AMY2A AMY2B

9.99e-0810203int:AMY2B
InteractionHTN3 interactions

AMY1A AMY1B AMY1C

3.34e-0630203int:HTN3
InteractionZNF843 interactions

AMY2A AMY2B

8.45e-0514202int:ZNF843
InteractionAMY2A interactions

AMY2A AMY2B

1.94e-0421202int:AMY2A
InteractionDUSP4 interactions

AMY1A AMY2A AMY2B

2.07e-04118203int:DUSP4
CytobandEnsembl 112 genes in cytogenetic band chr4q35

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7 DUX4L9

1.45e-15117258chr4q35
Cytoband4q35.2

DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

4.00e-15272564q35.2
Cytoband1p21

AMY1A AMY1B AMY1C AMY2A AMY2B

1.32e-12242551p21
CytobandEnsembl 112 genes in cytogenetic band chr1p21

AMY1A AMY1B AMY1C AMY2A AMY2B

3.20e-09107255chr1p21
GeneFamilyPRD class homeoboxes and pseudogenes

DUX4L2 DUXA DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7 DUX4L9

2.06e-1592158521
CoexpressionLEE_AGING_MUSCLE_UP

AMY1B AMY1C AMY2A AMY2B

5.35e-0841244MM698
CoexpressionBERGER_MBD2_TARGETS

AMY1B AMY2A AMY2B

1.11e-0711243MM905
CoexpressionMCCLUNG_CREB1_TARGETS_DN

AMY1B AMY1C AMY2A AMY2B

2.55e-0760244MM654
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_DN

DUX4 SFI1 SNAPC4 DUX4L5 DUX4L6 DUX4L4 DUX4L7 TBC1D1

9.10e-07909248M41018
CoexpressionNAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP

AMY1A AMY1B AMY1C AMY2A AMY2B GNAS

1.28e-06399246M41172
CoexpressionIGLESIAS_E2F_TARGETS_DN

AMY1B AMY2A AMY2B

1.94e-0627243MM643
CoexpressionCADWELL_ATG16L1_TARGETS_UP

AMY1B AMY1C AMY2A AMY2B

3.61e-06116244MM1240
CoexpressionCHEBOTAEV_GR_TARGETS_DN

AMY1B AMY1C AMY2A AMY2B

6.04e-06132244MM470
CoexpressionBOYLAN_MULTIPLE_MYELOMA_PCA1_UP

AMY1B AMY1C AMY2A AMY2B

8.29e-06143244MM1056
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP

AMY1B AMY1C AMY2A AMY2B

1.49e-05166244MM563
CoexpressionOHGUCHI_LIVER_HNF4A_TARGETS_UP

AMY1B AMY2A AMY2B

1.62e-0554243MM889
CoexpressionBORLAK_LIVER_CANCER_EGF_UP

AMY1B AMY2A AMY2B

1.91e-0557243MM527
CoexpressionSERVITJA_ISLET_HNF1A_TARGETS_UP

AMY1B AMY1C AMY2A AMY2B

2.29e-05185244MM1072
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_3DY_DN

AMY1A AMY1B AMY1C SFI1 AMY2A

3.90e-05432245M41149
CoexpressionCAIRO_LIVER_DEVELOPMENT_DN

AMY1B AMY1C AMY2A AMY2B

6.21e-05239244MM1274
CoexpressionLEIN_MIDBRAIN_MARKERS

AMY1B AMY2A AMY2B

7.03e-0588243MM717
CoexpressionLIAN_LIPA_TARGETS_6M

AMY1B AMY2A AMY2B

9.40e-0597243MM1016
CoexpressionCUI_TCF21_TARGETS_2_DN

AMY1B ATP8B1 AMY1C AMY2A AMY2B TBC1D1

1.19e-04888246MM1018
CoexpressionRAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN

AMY1B AMY1C AMY2A AMY2B

1.29e-04289244MM1238
CoexpressionBOYLAN_MULTIPLE_MYELOMA_C_D_DN

AMY1B AMY1C AMY2A AMY2B

1.53e-04302244MM1046
CoexpressionSHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4

AMY1B AMY1C AMY2A AMY2B

2.15e-04330244MM1120
CoexpressionMARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN

DUX4L2 DUX4L4 DUX4L9

4.82e-04169243MM526
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP

AMY1A AMY1B AMY1C AMY2A AMY2B TBC1D1

6.42e-041215246M41122
CoexpressionZENG_GU_ICB_CONTROL_METAGENE_19_PRECICTIVE_ICB_RESPONSE

DUX4L2 DUX4L4 DUX4L9

7.53e-04197243MM17080
CoexpressionAtlassalivary gland

AMY1A AMY1B AMY1C

3.76e-0583173salivary gland
Drug4,6-O-3-ketobutylidene maltopentaose

AMY1A AMY1B AMY1C AMY2A AMY2B

6.25e-156255CID003083414
DrugCNP-G3

AMY1A AMY1B AMY1C AMY2A AMY2B

6.25e-156255CID003082910
DrugR 623

AMY1A AMY1B AMY1C AMY2A AMY2B

6.25e-156255CID003027594
Drugdimethylaminomethylferrocene

AMY1A AMY1B AMY1C AMY2A AMY2B

6.25e-156255CID000102082
Drugmono-6-deoxy-6-fluorocyclomaltoheptaose

AMY1A AMY1B AMY1C AMY2A AMY2B

6.25e-156255CID000127364
Drugmercuric thiocyanate

AMY1A AMY1B AMY1C AMY2A GNAS

6.25e-156255CID000011615
DrugS-p-nitrobenzyloxycarbonylglutathione

AMY1A AMY1B AMY1C AMY2A AMY2B GNAS TBC1D1

1.15e-1439257CID004632704
DrugBG5P

AMY1A AMY1B AMY1C AMY2A AMY2B

2.19e-147255CID003082752
DrugAC1L5BOU

AMY1A AMY1B AMY1C AMY2A AMY2B

2.19e-147255CID000174858
Drugdesethylaprophen

AMY1A AMY1B AMY1C AMY2A AMY2B

5.83e-148255CID000163919
Drugazintamide

AMY1A AMY1B AMY1C AMY2A AMY2B

5.83e-148255CID000071105
Drugalpha-maltosyl fluoride

AMY1A AMY1B AMY1C AMY2A AMY2B

1.31e-139255CID000194237
Drugtrestatin A

AMY1A AMY1B AMY1C AMY2A AMY2B

1.31e-139255CID003054994
DrugAC1LAC07

AMY1A AMY1B AMY1C AMY2A AMY2B

2.62e-1310255CID000485275
DrugAC1L3M0Q

AMY1A AMY1B AMY1C AMY2A AMY2B

2.62e-1310255CID000118008
DrugGlc)4

AMY1A AMY1B AMY1C AMY2A AMY2B

2.62e-1310255CID000189098
DrugRo 20-0083

AMY1A AMY1B AMY1C AMY2A AMY2B

2.62e-1310255CID003082332
Drugvalidamycin D

AMY1A AMY1B AMY1C AMY2A AMY2B

4.80e-1311255CID000166726
DrugHgI2

AMY1A AMY1B AMY1C AMY2A AMY2B

4.80e-1311255CID000024485
Drug2C KM

AMY1A AMY1B AMY1C AMY2A AMY2B

4.80e-1311255CID009549196
DrugFG5P

AMY1A AMY1B AMY1C AMY2A AMY2B

4.80e-1311255CID000127486
DrugCNP-G5

AMY1A AMY1B AMY1C AMY2A AMY2B

4.80e-1311255CID000127309
Drugazaprophen

AMY1A AMY1B AMY1C AMY2A AMY2B

8.21e-1312255CID000129486
DrugAvenin

AMY1A AMY1B AMY1C AMY2A GNAS

8.21e-1312255CID000095924
DrugDembrexine

AMY1A AMY1B AMY1C AMY2A

1.13e-124254CID000072009
Drugg lw

AMY1A AMY1B AMY1C AMY2A

1.13e-124254CID000444139
DrugAC1MQT4V

AMY1A AMY1B AMY1C AMY2A

1.13e-124254CID003482066
Drugbeta-santalene

AMY1A AMY1B AMY1C AMY2A

1.13e-124254CID000010534
Drug2-nitropropyl acetate

AMY1A AMY1B AMY1C AMY2A

1.13e-124254CID013573844
DrugN-PMT

AMY1A AMY1B AMY1C AMY2A

1.13e-124254CID000194224
DrugSAIB-SG

AMY1A AMY1B AMY1C AMY2A

1.13e-124254CID002735139
Drugmethyl 1'-epiacarviosin

AMY1A AMY1B AMY1C AMY2A AMY2B

1.33e-1213255CID000197426
Drugisoacarbose

AMY1A AMY1B AMY1C AMY2A AMY2B

1.33e-1213255CID000449165
DrugCyclodextrins

AMY1A AMY1B AMY1C AMY2A AMY2B

2.07e-1214255CID000024238
Drugterephthaloyl chloride

AMY1A AMY1B AMY1C AMY2A AMY2B

2.07e-1214255CID000007488
Drug2-chloro-4-nitrophenol

AMY1A AMY1B AMY1C AMY2A AMY2B

2.07e-1214255CID000012074
Drug4-nitrophenylmaltoheptaoside

AMY1A AMY1B AMY1C AMY2A AMY2B

3.11e-1215255CID000173254
Druggamma-cyclodextrin

AMY1A AMY1B AMY1C AMY2A AMY2B

4.52e-1216255CID000086575
DrugBay e 4609

AMY1A AMY1B AMY1C AMY2A AMY2B

4.52e-1216255CID003085308
Drugcimicifugic acid A

AMY1A AMY1B AMY1C AMY2A

5.65e-125254CID006449879
Drugsilver perchlorate

AMY1A AMY1B AMY1C AMY2A

5.65e-125254CID000024562
Drugactinidine

AMY1A AMY1B AMY1C AMY2A

5.65e-125254CID000068231
DrugDeposiston

AMY1A AMY1B AMY1C AMY2A

5.65e-125254CID003080829
Druglunularic acid

AMY1A AMY1B AMY1C AMY2A

5.65e-125254CID000161413
Drug2-[[(2-amino-1,3-thiazol-4-yl)-(2-oxoethylcarbamoyl)methylidene]amino]oxy-2-methyl-propanoic Acid

AMY1A AMY1B AMY1C AMY2A

5.65e-125254CID010358258
Drughimachalene

AMY1A AMY1B AMY1C AMY2A

5.65e-125254CID000015095
Drug2TAA

AMY1A AMY1B AMY1C AMY2A

5.65e-125254CID000127374
DrugAC1L4DZ4

AMY1A AMY1B AMY1C AMY2A

5.65e-125254CID000155287
Drugtrimitan

AMY1A AMY1B AMY1C AMY2A AMY2B

8.85e-1218255CID000005561
Drugaprophen

AMY1A AMY1B AMY1C AMY2A AMY2B

8.85e-1218255CID000071128
Drug(2S)-2-acetamido-3-[(3E)-3-[(4-arsonophenyl)hydrazono]-4-oxo-cyclohexa-1,5-dien-1-yl]propanoic acid

AMY1A AMY1B AMY1C AMY2A

1.69e-116254CID009577343
DrugBorane dimethylamine complex

AMY1A AMY1B AMY1C AMY2A

1.69e-116254CID009898794
DrugAC1L3OV4

AMY1A AMY1B AMY1C AMY2A

1.69e-116254CID000092801
Drug2-amino-6-picoline

AMY1A AMY1B AMY1C AMY2A

1.69e-116254CID000015765
Drugphenol blue

AMY1A AMY1B AMY1C AMY2A

1.69e-116254CID000075078
DrugAC1OAGH8

AMY1A AMY1B AMY1C AMY2A

1.69e-116254CID006857368
Drugvermella

AMY1A AMY1B AMY1C AMY2A

1.69e-116254CID000203726
DrugGu-4

AMY1A AMY1B AMY1C AMY2A

1.69e-116254CID000448679
Drughymenin

AMY1A AMY1B AMY1C AMY2A

1.69e-116254CID000010499
DrugAC1L3XPY

AMY1A AMY1B AMY1C AMY2A AMY2B

2.10e-1121255CID000124005
DrugEudragit RS

AMY1A AMY1B AMY1C AMY2A TBC1D1

2.71e-1122255CID000104931
Drugmaltosaccharide

AMY1A AMY1B AMY1C AMY2A AMY2B

2.71e-1122255CID005461034
DrugParamax

AMY1A AMY1B AMY1C AMY2A

3.95e-117254CID000156411
Drug3KBG5CNP

AMY1A AMY1B AMY1C AMY2A

3.95e-117254CID003083250
DrugAC1L9UU3

AMY1A AMY1B AMY1C AMY2A

3.95e-117254CID000071762
Drugmethyl blue

AMY1A AMY1B AMY1C AMY2A

3.95e-117254CID011969534
Drugamino-methyl

AMY1A AMY1B AMY1C AMY2A

3.95e-117254CID000142005
DrugPanose B

AMY1A AMY1B AMY1C AMY2A AMY2B

4.37e-1124255CID000439297
DrugCID439354

AMY1A AMY1B AMY1C AMY2A AMY2B

5.46e-1125255CID000439354
Drugboric acid gel

AMY1A AMY1B AMY1C AMY2A

7.89e-118254CID003016474
DrugAC1NSVJM

AMY1A AMY1B AMY1C AMY2A

7.89e-118254CID005317411
Drugtheodrenaline

AMY1A AMY1B AMY1C AMY2A

7.89e-118254CID000071857
Drugrhodanile blue

AMY1A AMY1B AMY1C AMY2A

7.89e-118254CID000073372
DrugN-vinylcaprolactam

AMY1A AMY1B AMY1C AMY2A

7.89e-118254CID000075227
Drug9-azidoacridine

AMY1A AMY1B AMY1C AMY2A

7.89e-118254CID000146692
Drugacrinor

AMY1A AMY1B AMY1C AMY2A

7.89e-118254CID005489637
DrugNSC300622

AMY1A AMY1B AMY1C AMY2A

7.89e-118254CID000028426
DrugAtonik

AMY1A AMY1B AMY1C AMY2A

1.42e-109254CID000069471
DrugGSAD

AMY1A AMY1B AMY1C AMY2A

1.42e-109254CID009909127
Drugzingiberene

AMY1A AMY1B AMY1C AMY2A

1.42e-109254CID000092776
DrugH 187

AMY1A AMY1B AMY1C AMY2A

1.42e-109254CID000001742
DrugGU-3

AMY1A AMY1B AMY1C AMY2A

1.42e-109254CID000448687
Drugmercuric nitrate

AMY1A AMY1B AMY1C AMY2A

1.42e-109254CID000024864
DrugN,N'-disalicylidene-1,3-diaminopropane

AMY1A AMY1B AMY1C AMY2A AMY2B

1.46e-1030255CID005373003
DrugFolin Marenzi reagent

AMY1A AMY1B AMY1C AMY2A AMY2B

2.06e-1032255CID000452313
DrugI ZE

AMY1A AMY1B AMY1C AMY2A

2.36e-1010254CID009549200
Drugeicosa-11,14-dienoic acid

AMY1A AMY1B AMY1C AMY2A

2.36e-1010254CID000003208
Drugtrans-cinnamamide

AMY1A AMY1B AMY1C AMY2A

2.36e-1010254CID000012135
DrugCG-120

AMY1A AMY1B AMY1C AMY2A

2.36e-1010254CID000171403
DrugUDP-pyridoxal

AMY1A AMY1B AMY1C AMY2A

2.36e-1010254CID000126789
Drugnaphthalene-1,3,6,8-tetrol

AMY1A AMY1B AMY1C AMY2A

2.36e-1010254CID000440202
DrugR625

AMY1A AMY1B AMY1C AMY2A AMY2B

2.42e-1033255CID000072375
DrugPNPC

AMY1A AMY1B AMY1C AMY2A AMY2B

3.31e-1035255CID000165125
DrugTempamine

AMY1A AMY1B AMY1C AMY2A

3.71e-1011254CID000550942
DrugL-tert-leucine

AMY1A AMY1B AMY1C AMY2A

3.71e-1011254CID000164608
DrugAMO-1618

AMY1A AMY1B AMY1C AMY2A

3.71e-1011254CID000017103
DrugAC1L8PXO

AMY1A AMY1B AMY1C AMY2A

3.71e-1011254CID000430710
DrugBCDs

AMY1A AMY1B AMY1C AMY2A AMY2B

4.44e-1037255CID000364214
DrugAC1L4W0B

AMY1A AMY1B AMY1C AMY2A

5.56e-1012254CID000193311
Drugchitosan

AMY1A AMY1B AMY1C AMY2A

5.56e-1012254CID000071853
Diseasealpha-amylase 1 measurement

AMY1A AMY1C AMY2A AMY2B

1.54e-119194EFO_0801371
DiseaseSclerocystic Ovaries

GNAS DUX4L5

3.83e-03144192C1136382
DiseasePolycystic Ovary Syndrome

GNAS DUX4L5

3.83e-03144192C0032460
Diseaseamyotrophic lateral sclerosis

LHX8 TBC1D1

3.88e-03145192MONDO_0004976

Protein segments in the cluster

PeptideGeneStartEntry
WFQNERSRQLRQHRR

DUX4L4

66

P0CJ87
SRIQIWFQNRRARHP

DUX4L4

136

P0CJ87
HRWRQIRNMVNFRNV

AMY1B

401

P0DTE7
HRWRQIRNMVNFRNV

AMY1C

401

P0DTE8
HRWRQIRNMVNFRNV

AMY1A

401

P0DUB6
WFQNERSRQLRQHRR

DUX4L6

66

P0CJ89
SRIQIWFQNRRARHP

DUX4L6

136

P0CJ89
HRWRQIRNMVNFRNV

AMY2B

401

P19961
WQRRQQVFRRGVSTR

ATP8B1

1191

O43520
HRWRQIRNMVIFRNV

AMY2A

401

P04746
WFQNERSRQLRQHRR

DUX4

66

Q9UBX2
SRIQIWFQNRRARHP

DUX4

136

Q9UBX2
QIWFQNRRARHRGQS

DUX5

166

Q96PT3
WFQNERSRQLRQHRR

DUX4L3

66

P0CJ86
SRIQIWFQNRRARHP

DUX4L3

136

P0CJ86
RRVIQVWFQNCRARH

LHX8

266

Q68G74
RSRTLANNRRNVWFA

GRM8

346

O00222
WFQNERSRQLRQHRR

DUX4L9

66

Q6RFH8
SRIQIWFQNRRARHP

DUX4L9

136

Q6RFH8
WFQNERSRQLRQHRR

DUX4L7

66

P0CJ90
SRIQIWFQNRRARHP

DUX4L7

136

P0CJ90
WFQNERSCQLRQHRR

DUX1

66

O43812
SRIQIWFQNRRARHR

DUX1

136

O43812
FHLWIRRNRERNSRS

KHDC1

46

Q4VXA5
WFQNERSRQLRQHRR

DUX4L5

66

P0CJ88
SRIQIWFQNRRARHP

DUX4L5

136

P0CJ88
ESRIQIWFQNRRARH

DUXA

56

A6NLW8
VRNLRWRRAFQRNTA

RTL1

996

A6NKG5
WRRAFQRNTAARQTL

RTL1

1001

A6NKG5
RTCFRQWRQQLAARR

SFI1

821

A8K8P3
WFQHRRNRRRRKPQR

GNAS

591

Q5JWF2
WYQHRQRKLRRNRRS

HEPH

1131

Q9BQS7
TRRHSWRQQIFLRVA

TBC1D1

656

Q86TI0
VQWLRHRATQSGQRR

SNAPC4

716

Q5SXM2
RLHLKRFRWSGRNNR

USP44

571

Q9H0E7
WFQNERSRQLRQHRR

DUX4L2

66

P0CJ85
SRIQIWFQNRRARHP

DUX4L2

136

P0CJ85