Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	lipid transporter activity	SLC22A6 ABCD4 XKR8 ATP10B ABCD1 ABCD2 GLTPD2 ATP10D	2.25e-06	196	87	8	GO:0005319
GeneOntologyMolecularFunction	glycosylceramide flippase activity	ATP10B ATP10D	5.61e-05	3	87	2	GO:0140351
GeneOntologyMolecularFunction	long-chain fatty acid transmembrane transporter activity	ABCD4 ABCD1 ABCD2	6.22e-05	18	87	3	GO:0005324
GeneOntologyMolecularFunction	sphingolipid transporter activity	ATP10B GLTPD2 ATP10D	8.63e-05	20	87	3	GO:0046624
GeneOntologyMolecularFunction	fatty acid transmembrane transporter activity	ABCD4 ABCD1 ABCD2	1.33e-04	23	87	3	GO:0015245
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	SLC22A6 ABCD4 ABCD1 ABCD2	2.91e-04	73	87	4	GO:0170055
GeneOntologyBiologicalProcess	long-chain fatty acid import into peroxisome	ABCD4 ABCD1 ABCD2	2.89e-07	4	87	3	GO:0015910
GeneOntologyBiologicalProcess	very long-chain fatty acid metabolic process	ACSL6 ABCD4 ELOVL3 ABCD1 ABCD2	3.49e-07	35	87	5	GO:0000038
GeneOntologyBiologicalProcess	fatty acid transmembrane transport	ACSL6 ABCD4 ABCD1 ABCD2	2.04e-06	22	87	4	GO:1902001
GeneOntologyBiologicalProcess	very long-chain fatty acid catabolic process	ABCD4 ABCD1 ABCD2	2.51e-06	7	87	3	GO:0042760
GeneOntologyBiologicalProcess	lipid localization	ACSL6 TTC39B SLC22A6 ABCD4 XKR8 ATP10B PNPLA8 ABCD1 ABCD2 GLTPD2 ATP10D FBXW7	4.34e-06	565	87	12	GO:0010876
GeneOntologyBiologicalProcess	lipid transport	ACSL6 TTC39B SLC22A6 ABCD4 XKR8 ATP10B PNPLA8 ABCD1 ABCD2 GLTPD2 ATP10D	9.05e-06	506	87	11	GO:0006869
GeneOntologyBiologicalProcess	long-chain fatty acid transport	ACSL6 ABCD4 PNPLA8 ABCD1 ABCD2	1.52e-05	74	87	5	GO:0015909
GeneOntologyBiologicalProcess	fatty acid transport	ACSL6 SLC22A6 ABCD4 PNPLA8 ABCD1 ABCD2	2.02e-05	132	87	6	GO:0015908
GeneOntologyBiologicalProcess	unsaturated fatty acid biosynthetic process	ELOVL3 PNPLA8 ABCD1 ABCD2	9.17e-05	56	87	4	GO:0006636
GeneOntologyBiologicalProcess	peroxisomal membrane transport	ABCD4 ABCD1 ABCD2	1.05e-04	22	87	3	GO:0015919
GeneOntologyBiologicalProcess	peroxisomal transport	ABCD4 ABCD1 ABCD2	1.05e-04	22	87	3	GO:0043574
GeneOntologyBiologicalProcess	linoleic acid metabolic process	ELOVL3 PNPLA8 ABCD1	1.21e-04	23	87	3	GO:0043651
GeneOntologyBiologicalProcess	Wnt protein secretion	PORCN PTPN23	2.61e-04	6	87	2	GO:0061355
GeneOntologyBiologicalProcess	monocarboxylic acid transport	ACSL6 SLC22A6 ABCD4 PNPLA8 ABCD1 ABCD2	2.85e-04	213	87	6	GO:0015718
GeneOntologyCellularComponent	microbody membrane	ACSL6 ABCD4 PNPLA8 ABCD1 ABCD2	9.57e-06	69	86	5	GO:0031903
GeneOntologyCellularComponent	peroxisomal membrane	ACSL6 ABCD4 PNPLA8 ABCD1 ABCD2	9.57e-06	69	86	5	GO:0005778
GeneOntologyCellularComponent	microbody	ACSL6 ABCD4 PNPLA8 ABCD1 NUDT17 ABCD2	5.56e-05	162	86	6	GO:0042579
GeneOntologyCellularComponent	peroxisome	ACSL6 ABCD4 PNPLA8 ABCD1 NUDT17 ABCD2	5.56e-05	162	86	6	GO:0005777
GeneOntologyCellularComponent	CKM complex	CDK8 CDK19	1.66e-04	5	86	2	GO:1990508
GeneOntologyCellularComponent	ionotropic glutamate receptor complex	CPT1C PORCN GRIN2A	8.42e-04	45	86	3	GO:0008328
GeneOntologyCellularComponent	neurotransmitter receptor complex	CPT1C PORCN GRIN2A	1.15e-03	50	86	3	GO:0098878
GeneOntologyCellularComponent	phospholipid-translocating ATPase complex	ATP10B ATP10D	1.47e-03	14	86	2	GO:1990531
Domain	ABC_membrane_2	ABCD4 ABCD1 ABCD2	3.76e-07	4	86	3	PF06472
Domain	ABC_TM1F	ABCD4 ABCD1 ABCD2	2.84e-04	28	86	3	PS50929
Domain	ABC1_TM_dom	ABCD4 ABCD1 ABCD2	2.84e-04	28	86	3	IPR011527
Domain	-	DNAJC13 IPO7 MROH5 IPO13 FRYL HEATR5B	5.62e-04	222	86	6	1.25.10.10
Domain	Hydrolase_3	ATP10B ATP10D	9.21e-04	10	86	2	PF08282
Domain	ABC_transporter_CS	ABCD4 ABCD1 ABCD2	9.50e-04	42	86	3	IPR017871
Domain	ABC_tran	ABCD4 ABCD1 ABCD2	1.40e-03	48	86	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCD4 ABCD1 ABCD2	1.40e-03	48	86	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCD4 ABCD1 ABCD2	1.49e-03	49	86	3	PS00211
Domain	ARM-like	DNAJC13 IPO7 MROH5 IPO13 FRYL HEATR5B	1.54e-03	270	86	6	IPR011989
Domain	ABC_transporter-like	ABCD4 ABCD1 ABCD2	1.58e-03	50	86	3	IPR003439
Domain	Protein_kinase_ATP_BS	CDK8 TYK2 NRK CDK19 MYLK4 MAPK4 PLK3	1.82e-03	379	86	7	IPR017441
Domain	IMPORTIN_B_NT	IPO7 IPO13	1.84e-03	14	86	2	PS50166
Domain	P_typ_ATPase_c	ATP10B ATP10D	1.84e-03	14	86	2	IPR032630
Domain	P-type_ATPase_N	ATP10B ATP10D	1.84e-03	14	86	2	IPR032631
Domain	P-type_ATPase_IV	ATP10B ATP10D	1.84e-03	14	86	2	IPR006539
Domain	PhoLip_ATPase_C	ATP10B ATP10D	1.84e-03	14	86	2	PF16212
Domain	PhoLip_ATPase_N	ATP10B ATP10D	1.84e-03	14	86	2	PF16209
Domain	IBN_N	IPO7 IPO13	2.12e-03	15	86	2	PF03810
Domain	IBN_N	IPO7 IPO13	2.41e-03	16	86	2	SM00913
Domain	Importin-beta_N	IPO7 IPO13	2.72e-03	17	86	2	IPR001494
Domain	TSP_1	THBS2 UNC5B SSPOP	3.07e-03	63	86	3	PF00090
Domain	TSP1	THBS2 UNC5B SSPOP	3.35e-03	65	86	3	SM00209
Domain	TSP1_rpt	THBS2 UNC5B SSPOP	3.35e-03	65	86	3	IPR000884
Domain	TSP1	THBS2 UNC5B SSPOP	3.35e-03	65	86	3	PS50092
Domain	CONNEXINS_2	GJD3 GJA10	3.77e-03	20	86	2	PS00408
Domain	Connexin	GJD3 GJA10	3.77e-03	20	86	2	IPR000500
Domain	Connexin_CCC	GJD3 GJA10	3.77e-03	20	86	2	IPR019570
Domain	Connexin_N	GJD3 GJA10	3.77e-03	20	86	2	IPR013092
Domain	Connexin	GJD3 GJA10	3.77e-03	20	86	2	PF00029
Domain	Connexin_CCC	GJD3 GJA10	3.77e-03	20	86	2	SM01089
Domain	Connexin_CS	GJD3 GJA10	3.77e-03	20	86	2	IPR017990
Domain	CNX	GJD3 GJA10	3.77e-03	20	86	2	SM00037
Domain	ARM-type_fold	DNAJC13 IPO7 MROH5 IPO13 FRYL HEATR5B	4.76e-03	339	86	6	IPR016024
Domain	PROTEIN_KINASE_ATP	CDK8 TYK2 NRK CDK19 MYLK4 MAPK4 PLK3	5.24e-03	459	86	7	PS00107
Domain	Ser/Thr_kinase_AS	CDK8 NRK CDK19 MYLK4 MAPK4 PLK3	6.10e-03	357	86	6	IPR008271
Domain	S_TKc	CDK8 NRK CDK19 MYLK4 MAPK4 PLK3	6.26e-03	359	86	6	SM00220
Domain	PROTEIN_KINASE_ST	CDK8 NRK CDK19 MYLK4 MAPK4 PLK3	6.52e-03	362	86	6	PS00108
Domain	Prot_kinase_dom	CDK8 TYK2 NRK CDK19 MYLK4 MAPK4 PLK3	7.33e-03	489	86	7	IPR000719
Domain	PROTEIN_KINASE_DOM	CDK8 TYK2 NRK CDK19 MYLK4 MAPK4 PLK3	7.65e-03	493	86	7	PS50011
Domain	Pkinase	CDK8 NRK CDK19 MYLK4 MAPK4 PLK3	8.28e-03	381	86	6	PF00069
Pubmed	Identification of novel SNPs of ABCD1, ABCD2, ABCD3, and ABCD4 genes in patients with X-linked adrenoleukodystrophy (ALD) based on comprehensive resequencing and association studies with ALD phenotypes.	ABCD4 ABCD1 ABCD2	6.25e-08	4	88	3	20661612
Pubmed	ABC Transporter Subfamily D: Distinct Differences in Behavior between ABCD1-3 and ABCD4 in Subcellular Localization, Function, and Human Disease.	ABCD4 ABCD1 ABCD2	6.25e-08	4	88	3	27766264
Pubmed	The four murine peroxisomal ABC-transporter genes differ in constitutive, inducible and developmental expression.	ABCD4 ABCD1 ABCD2	5.44e-07	7	88	3	10504404
Pubmed	Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy.	ABCD1 ABCD2	6.33e-06	2	88	2	20179078
Pubmed	CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: novel microglial models for X-linked Adrenoleukodystrophy.	ABCD1 ABCD2	6.33e-06	2	88	2	30769094
Pubmed	A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.	ABCD1 ABCD2	6.33e-06	2	88	2	18854420
Pubmed	Mediator kinase inhibition further activates super-enhancer-associated genes in AML.	CDK8 CDK19	6.33e-06	2	88	2	26416749
Pubmed	Peroxisomal ATP-binding cassette transporters form mainly tetramers.	ABCD1 ABCD2	6.33e-06	2	88	2	28258215
Pubmed	Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.	CDK8 CDK19	6.33e-06	2	88	2	32560467
Pubmed	CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.	CDK8 CDK19	6.33e-06	2	88	2	28855340
Pubmed	Targeted Brain Delivery of Dendrimer-4-Phenylbutyrate Ameliorates Neurological Deficits in a Long-Term ABCD1-Deficient Mouse Model of X-Linked Adrenoleukodystrophy.	ABCD1 ABCD2	6.33e-06	2	88	2	36207570
Pubmed	Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.	CDK8 CDK19	6.33e-06	2	88	2	35181333
Pubmed	Regulatory functions of the Mediator kinases CDK8 and CDK19.	CDK8 CDK19	6.33e-06	2	88	2	30585107
Pubmed	Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers.	ABCD1 ABCD2	6.33e-06	2	88	2	25043761
Pubmed	Abcd2 is a strong modifier of the metabolic impairments in peritoneal macrophages of ABCD1-deficient mice.	ABCD1 ABCD2	6.33e-06	2	88	2	25255441
Pubmed	ATP-binding and -hydrolysis activities of ALDP (ABCD1) and ALDRP (ABCD2), human peroxisomal ABC proteins, overexpressed in Sf21 cells.	ABCD1 ABCD2	6.33e-06	2	88	2	16946495
Pubmed	Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.	CDK8 CDK19	6.33e-06	2	88	2	27678455
Pubmed	HIV Transcription Is Independent of Mediator Kinases.	CDK8 CDK19	6.33e-06	2	88	2	31044597
Pubmed	Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy.	ABCD1 ABCD2	6.33e-06	2	88	2	15489218
Pubmed	CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.	CDK8 CDK19	6.33e-06	2	88	2	36006697
Pubmed	Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid β-oxidation.	ABCD1 ABCD2	6.33e-06	2	88	2	21145416
Pubmed	[Mechanisms of transcriptional regulation upon protein phosphorylation by mediator complexes].	CDK8 CDK19	6.33e-06	2	88	2	20408451
Pubmed	The role of peroxisomal ABC transporters in the mouse adrenal gland: the loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage.	ABCD1 ABCD2	6.33e-06	2	88	2	17260006
Pubmed	CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.	CDK8 CDK19	6.33e-06	2	88	2	37378433
Pubmed	Targeting of the human adrenoleukodystrophy protein to the peroxisomal membrane by an internal region containing a highly conserved motif.	ABCD4 ABCD1	6.33e-06	2	88	2	14533738
Pubmed	Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy.	ABCD1 ABCD2	6.33e-06	2	88	2	18723473
Pubmed	Adrenoleukodystrophy-related protein can compensate functionally for adrenoleukodystrophy protein deficiency (X-ALD): implications for therapy.	ABCD1 ABCD2	6.33e-06	2	88	2	10196381
Pubmed	Identification of target genes for the CDK subunits of the Mediator complex.	CDK8 CDK19	6.33e-06	2	88	2	22117896
Pubmed	Live cell FRET microscopy: homo- and heterodimerization of two human peroxisomal ABC transporters, the adrenoleukodystrophy protein (ALDP, ABCD1) and PMP70 (ABCD3).	ABCD1 ABCD2	1.90e-05	3	88	2	17609205
Pubmed	Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.	CDK8 CDK19	1.90e-05	3	88	2	26002960
Pubmed	Homo- and heterodimerization of peroxisomal ATP-binding cassette half-transporters.	ABCD1 ABCD2	1.90e-05	3	88	2	10551832
Pubmed	Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.	ABCD1 ABCD2	1.90e-05	3	88	2	25822341
Pubmed	Characterization of human ATP-binding cassette protein subfamily D reconstituted into proteoliposomes.	ABCD1 ABCD2	1.90e-05	3	88	2	29397936
Pubmed	CEMIP promotes small cell lung cancer proliferation by activation of glutamine metabolism via FBXW7/c-Myc-dependent axis.	FBXW7 CEMIP	1.90e-05	3	88	2	36746261
Pubmed	Peroxisomal ABC Transporters: An Update.	ABCD1 ABCD2	1.90e-05	3	88	2	34198763
Pubmed	Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.	CDK8 CDK19	1.90e-05	3	88	2	28151579
Pubmed	Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy.	ABCD1 ABCD2	3.79e-05	4	88	2	29997171
Pubmed	Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.	CDK8 CDK19	3.79e-05	4	88	2	29440396
Pubmed	Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p.	ABCD1 ABCD2	3.79e-05	4	88	2	10777694
Pubmed	Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.	CDK8 CDK19	3.79e-05	4	88	2	32439758
Pubmed	CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.	CDK8 CDK19	6.30e-05	5	88	2	36545778
Pubmed	Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly.	ABCD1 ABCD2	6.30e-05	5	88	2	11883941
Pubmed	Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues.	GJD3 GJA10	9.43e-05	6	88	2	12881038
Pubmed	Cyclin C is a haploinsufficient tumour suppressor.	CDK8 FBXW7	9.43e-05	6	88	2	25344755
Pubmed	Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics.	ATP10B ATP10D	9.43e-05	6	88	2	25947375
Pubmed	Subunit-specific regulation of NMDA receptor endocytosis.	GRIN2A AP4M1	1.32e-04	7	88	2	15254094
Pubmed	Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage.	ABCD1 ABCD2	1.32e-04	7	88	2	16223892
Pubmed	Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.	CDK8 CDK19	1.32e-04	7	88	2	22668559
Pubmed	Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13.	IPO7 IPO13	1.32e-04	7	88	2	15964792
Pubmed	Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein.	IPO7 IPO13	1.75e-04	8	88	2	36690276
Pubmed	Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.	CDK8 CDK19	1.75e-04	8	88	2	23749998
Pubmed	The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.	CDK8 CDK19	1.75e-04	8	88	2	30695077
Pubmed	ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.	ATP10B ATP10D	4.11e-04	12	88	2	21914794
Pubmed	A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.	CDK8 CDK19	4.11e-04	12	88	2	23563140
Pubmed	Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.	COG2 FCRLB HEATR5B	5.31e-04	62	88	3	17975119
Pubmed	Gene variants associated with ischemic stroke: the cardiovascular health study.	COG2 FCRLB HEATR5B	5.57e-04	63	88	3	19023099
Pubmed	Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases.	HDAC9 REV3L	5.65e-04	14	88	2	15964851
Pubmed	PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.	ABCD1 ABCD2	7.42e-04	16	88	2	10704444
Pubmed	Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.	CH25H SORCS1	8.40e-04	17	88	2	20413850
Pubmed	An expression atlas of connexin genes in the mouse.	GJD3 GJA10	9.43e-04	18	88	2	15081111
Pubmed	A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.	USP22 LCOR	9.43e-04	18	88	2	29628311
Pubmed	Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.	DXO EFNA3 ABCD1	1.04e-03	78	88	3	19204726
Pubmed	A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.	TYK2 REV3L	1.05e-03	19	88	2	20953190
Pubmed	An update on connexin genes and their nomenclature in mouse and man.	GJD3 GJA10	1.05e-03	19	88	2	14681012
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP22 C1RL USP27X	1.16e-03	81	88	3	12838346
Pubmed	Assessment of Alzheimer's disease case-control associations using family-based methods.	CH25H SORCS1	1.41e-03	22	88	2	18830724
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DNAJC13 MTMR4 FRYL	1.42e-03	87	88	3	12465718
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	SLC22A6 ABCD4 ABCD1 ABCD2	1.49e-03	193	88	4	19343046
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCD4 ABCD1	1.55e-03	23	88	2	10708515
Pubmed	High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.	CPT1C PORCN	1.68e-03	24	88	2	22632720
Pubmed	Intermediate phenotypes identify divergent pathways to Alzheimer's disease.	CH25H SORCS1	1.83e-03	25	88	2	20574532
Pubmed	Whole-genome sequencing reveals host factors underlying critical COVID-19.	TYK2 ACSL6	1.83e-03	25	88	2	35255492
Pubmed	Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia.	ABCD1 ABCD2	1.83e-03	25	88	2	35681537
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	HDAC9 IPO13 ATP10B	2.18e-03	101	88	3	9872452
Pubmed	SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.	DXO TTC39B TBC1D30 ALG9 ZNF256 ZNF772 AP4M1 PLK3	2.24e-03	915	88	8	32393512
Pubmed	Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.	CH25H SORCS1	2.29e-03	28	88	2	20534741
Pubmed	Biosynthesis of triacylglycerols.	ACSL6 ELOVL3	2.29e-03	28	88	2	8944226
GeneFamily	ATP binding cassette subfamily D	ABCD4 ABCD1 ABCD2	1.25e-07	4	58	3	808
GeneFamily	ATPase phospholipid transporting	ATP10B ATP10D	1.03e-03	15	58	2	1210
GeneFamily	Armadillo repeat containing\|Importins	IPO7 IPO13	1.50e-03	18	58	2	596
GeneFamily	Gap junction proteins	GJD3 GJA10	2.24e-03	22	58	2	314
GeneFamily	Cyclin dependent kinases	CDK8 CDK19	3.13e-03	26	58	2	496
GeneFamily	Cyclins\|Mediator complex	CDK8 CDK19	5.01e-03	33	58	2	1061
Disease	developmental and epileptic encephalopathy 87 (implicated_via_orthology)	CDK8 CDK19	7.63e-06	2	82	2	DOID:0112221 (implicated_via_orthology)
Disease	progressive familial intrahepatic cholestasis (implicated_via_orthology)	ATP10B ATP10D	2.28e-05	3	82	2	DOID:0070221 (implicated_via_orthology)
Disease	Adenocarcinoma of large intestine	CDK8 TYK2 NRK FBXW7	1.52e-04	96	82	4	C1319315
Disease	adrenoleukodystrophy (implicated_via_orthology)	ABCD1 ABCD2	1.59e-04	7	82	2	DOID:10588 (implicated_via_orthology)
Disease	glioblastoma (implicated_via_orthology)	USP22 USP27X	2.71e-04	9	82	2	DOID:3068 (implicated_via_orthology)
Disease	rheumatoid arthritis, COVID-19	TYK2 EFNA3 FRYL	7.63e-04	64	82	3	EFO_0000685, MONDO_0100096
Disease	phosphoenolpyruvic acid measurement	CMIP ALPL	7.82e-04	15	82	2	EFO_0010522
Disease	urate measurement	SLC22A6 DNAJC13 CMIP EFNA3 CPT1C ALG9 GJA10 HEATR5B CEMIP	8.46e-04	895	82	9	EFO_0004531
Disease	Infiltrating duct carcinoma of female breast	NRK MYLK4	1.55e-03	21	82	2	C3165106
Disease	ICAM-1 measurement	TYK2 ATG4D	2.02e-03	24	82	2	EFO_0004520
Disease	Varicose veins	DXO HDAC9 UNC5B GJD3	2.08e-03	193	82	4	HP_0002619

Protein segments in the cluster

Peptide	Gene	Start	Entry
WTQLRLSGHLKPLHY	TRHDE	136	Q9UKU6
NTHWYHSLPVRKKVL	ALKBH2	231	Q6NS38
YLHANWVLHRDLKPA	CDK19	141	Q9BWU1
ITHRPSLWKYHTHLL	ABCD2	661	Q9UBJ2
YIYHHSLIRISLKSW	ADGRA3	781	Q8IWK6
YLLLHAWPAAFHARI	ALG9	116	Q9H6U8
YLWRDKIIHSIHSVK	GJA10	526	Q969M2
LTSKFLRRWEPHHLT	CMIP	76	Q8IY22
PLSYVRAHLFKLWHH	DUS1L	266	Q6P1R4
LLYVSWRKDLTEHLH	ABCD4	106	O14678
LHLGFRHPWSFLTVK	CEMIP	261	Q8WUJ3
KLLLVHGHWCYSRLA	ATP10B	1096	O94823
SKLLLVHGHWCYTRL	ATP10D	1096	Q9P241
PHKWVRHLSHSDAYV	AP4M1	436	O00189
QSLKRSLVHLHFPTW	PTPN23	1341	Q9H3S7
SITHRPSLWKYHTHL	ABCD1	656	P33897
WSKARHYLLTHLPAV	KLHL33	91	A6NCF5
LWISSKLLSHDLPHY	KIAA0100	71	Q14667
LPTYHLWKRCRHLAE	MADCAM1	336	Q13477
RHWFSHSIPLAIFAL	GLTPD2	11	A6NH11
RLSWGLPKYHHIVLY	NUDT17	171	P0C025
TLRQHEKTHWLTRPY	HIC1	521	Q14526
SYLDKLLWRDNKPHH	MAPK4	436	P31152
LKPQHLTWYRTHLAR	CFAP65	571	Q6ZU64
AWKHLLCPDVSYRHL	IL17RE	441	Q8NFR9
HATWYVKAFLALLRP	BNIPL	296	Q7Z465
LSSHDPLWRRHCKKY	FBXO3	46	Q9UK99
HIIKHDYPSRWTAIV	IPO7	116	O95373
HLILSREASWAKPHY	LCOR	186	Q96JN0
AHHWIFIPLLAAYIS	OR51B6	21	Q9H340
SVKVEWGSYLHLLLH	FRYL	1611	O94915
TGWFSPYHRQRKLIH	HEXD	391	Q8WVB3
LKHPWLSDHKLHSRL	MYLK4	356	Q86YV6
HSPGQWRSFYRHKLL	DXO	261	O77932
RALHLWTAVYLPASS	MTMR4	561	Q9NYA4
PRYKHSHFIWNRTEL	ALPL	261	P05186
LLWRLGLPSYLKHAS	PORCN	41	Q9H237
TLHVALRLLLSYHGW	CPT1C	121	Q8TCG5
RLHYRNSWAPILHAV	HEATR5B	1521	Q9P2D3
YISTPTHNLHWKCLR	EFNA3	146	P52797
LRKRPLIFIHWYHHS	ELOVL3	136	Q9HB03
FIHSPWKSAYIRQHR	FBXW7	346	Q969H0
RWILTAAHTIYPKDS	C1RL	276	Q9NZP8
PVSHYRFWLFHILLL	GJD3	71	Q8N144
CYKHHWSDSRKPVIL	DNAJC13	116	O75165
WHFRHRLLHPSDKYE	IGFN1	341	Q86VF2
RLRAHPAYHSFNKKW	COG2	366	Q14746
WYLGHLLLPSHKKSI	FCRLB	61	Q6BAA4
NHSVSRHPKLWYTAA	HDAC9	166	Q9UKV0
RHPKLWYTAAHHTSL	HDAC9	171	Q9UKV0
YLHANWVLHRDLKPA	CDK8	141	P49336
WKYPLSLALHFHNKI	C5orf34	251	Q96MH7
PLHSWLILYSRSSHR	PIWIL3	506	Q7Z3Z3
AYAVPHWRHLQLLVS	SLC22A6	241	Q4U2R8
RGAVLHALRKTTYHW	METTL17	131	Q9H7H0
ALHIKISRYWSDIPT	IPO13	81	O94829
VWHLLHHKVPWLYRT	CH25H	141	O95992
AGLWLVTYLHALLHT	OR1C1	146	Q15619
LLSHLYIWLASEKAH	MROH5	586	Q6ZUA9
SGHKNRLRVYHLTWL	NRK	1266	Q7Z2Y5
FLFSPKHYWRISHIS	PNPLA8	31	Q9NP80
VCSLAWHIRLKLYHS	RSBN1L	681	Q6PCB5
SLPVHLRAHFTIWDK	MRPL39	301	Q9NYK5
AKWHTRPHYLQLDLL	SSPOP	2116	A2VEC9
LRKWHAYETAKVHPR	PKDREJ	1481	Q9NTG1
LAAILAYWFTHRPKA	ACSL6	36	Q9UKU0
IHRTPYEHKTVWKFL	CNBD1	146	Q8NA66
EILMHLWRYPSLSIH	CNDP1	336	Q96KN2
LPYHTLRTVHLTTWK	CYSLTR2	261	Q9NS75
WYGPSLVAHILRKAV	ATG4D	246	Q86TL0
SLAHIWKARHTLLEP	PLK3	146	Q9H4B4
HVPYKLLHLVWIHAR	USP27X	141	A6NNY8
PYKLLHLVWTHARHL	USP22	241	Q9UPT9
HFRIQAALHLWRKPS	TTC39B	666	Q5VTQ0
FSWYHELPRIHKATS	REV3L	3006	O60673
SYLISHWKVHTGARP	ZNF256	476	Q9Y2P7
RSKLAAHLWTHAPTR	ZNF575	131	Q86XF7
RKVWLTLADHYLHSI	TBC1D30	256	Q9Y2I9
ASVIYKIWEHRSHHP	TEX50	141	A0A1B0GTY4
HQSWIPRSEHRKYKV	nan	296	Q6ZUG5
LSLHDLPHAHWRSKL	UNC5B	756	Q8IZJ1
LPHAHWRSKLLAKYQ	UNC5B	761	Q8IZJ1
SLARHWRIHTGEKPY	ZNF415	446	Q09FC8
DYTAYRWHLTHRPKT	THBS2	1106	P35442
KHTSLPIRHLWLSFD	SORCS1	601	Q8WY21
YRLIKHWSVHTGARP	ZNF772	391	Q68DY9
YLIHWSTSHPYRLIL	TYK2	471	P29597
LALRLVYYHWLHPSC	XKR8	331	Q9H6D3
KLLRHAQWDHGLSIY	ZNF296	171	Q8WUU4
SRHYVHLERSPWKGL	AGL	1486	P35573
SHWLLHAYGIISISR	JKAMP	256	Q9P055
HTLSLRHAVWPRYKS	GRIN2A	381	Q12879