Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentsymmetric, GABA-ergic, inhibitory synapse

NLGN4Y NLGN4X

1.41e-0441022GO:0098983
DomainNLGN4

NLGN4Y NLGN4X

2.73e-052982IPR030025
DomainWD40

CORO1C NBEA DDB2 SHKBP1 NWD2 PAFAH1B1 WDR89 TAF5L

8.36e-05268988SM00320
DomainWD40_repeat

CORO1C NBEA DDB2 SHKBP1 NWD2 PAFAH1B1 WDR89 TAF5L

9.26e-05272988IPR001680
DomainWD_REPEATS_1

CORO1C NBEA DDB2 SHKBP1 NWD2 PAFAH1B1 WDR89 TAF5L

1.08e-04278988PS00678
DomainWD_REPEATS_2

CORO1C NBEA DDB2 SHKBP1 NWD2 PAFAH1B1 WDR89 TAF5L

1.10e-04279988PS50082
DomainWD_REPEATS_REGION

CORO1C NBEA DDB2 SHKBP1 NWD2 PAFAH1B1 WDR89 TAF5L

1.10e-04279988PS50294
DomainWD40_repeat_dom

CORO1C NBEA DDB2 SHKBP1 NWD2 PAFAH1B1 WDR89 TAF5L

1.70e-04297988IPR017986
DomainNlgn

NLGN4Y NLGN4X

2.70e-045982IPR000460
DomainR-trans_p

RTP4 RTP3

2.70e-045982IPR026096
Domain-

CORO1C NBEA DDB2 SHKBP1 NWD2 PAFAH1B1 WDR89 TAF5L

3.67e-043339882.130.10.10
DomainWD40/YVTN_repeat-like_dom

CORO1C NBEA DDB2 SHKBP1 NWD2 PAFAH1B1 WDR89 TAF5L

3.82e-04335988IPR015943
DomainPIP49_C

PKDCC DIPK2A

4.03e-046982PF12260
DomainFAM69_kinase_dom

PKDCC DIPK2A

4.03e-046982IPR022049
DomainWD40

CORO1C NBEA DDB2 SHKBP1 PAFAH1B1 WDR89 TAF5L

4.30e-04259987PF00400
Domainzf-3CxxC

RTP4 RTP3

5.63e-047982PF13695
Domainzf-3CxxC

RTP4 RTP3

7.48e-048982SM01328
DomainZnf-3CxxC

RTP4 RTP3

7.48e-048982IPR027377
DomainZU5

ANK2 ANK3

9.58e-049982SM00218
DomainZU5

ANK2 ANK3

1.19e-0310982PS51145
DomainWD40_repeat_CS

CORO1C DDB2 NWD2 PAFAH1B1 TAF5L

1.73e-03164985IPR019775
DomainTIL

MUC6 OTOG

1.74e-0312982PF01826
DomainZU5

ANK2 ANK3

1.74e-0312982PF00791
DomainZU5_dom

ANK2 ANK3

1.74e-0312982IPR000906
DomainC8

MUC6 OTOG

1.74e-0312982PF08742
DomainUnchr_dom_Cys-rich

MUC6 OTOG

2.05e-0313982IPR014853
DomainC8

MUC6 OTOG

2.05e-0313982SM00832
DomainCarboxylesterase_B_CS

NLGN4Y NLGN4X

2.05e-0313982IPR019819
DomainCARBOXYLESTERASE_B_2

NLGN4Y NLGN4X

2.38e-0314982PS00941
DomainTIL_dom

MUC6 OTOG

2.38e-0314982IPR002919
DomainCOesterase

NLGN4Y NLGN4X

2.38e-0314982PF00135
DomainCarbesteraseB

NLGN4Y NLGN4X

2.38e-0314982IPR002018
DomainVWD

MUC6 OTOG

3.12e-0316982SM00216
DomainVWF_type-D

MUC6 OTOG

3.12e-0316982IPR001846
DomainVWFD

MUC6 OTOG

3.12e-0316982PS51233
DomainVWD

MUC6 OTOG

3.12e-0316982PF00094
Domain-

DPP4 NLGN4Y NLGN4X PPME1

3.57e-031199843.40.50.1820
DomainAB_hydrolase

DPP4 NLGN4Y NLGN4X PPME1

3.57e-03119984IPR029058
DomainVWC_out

MUC6 OTOG

4.40e-0319982SM00215
DomainPDEase

PDE1B PDE8B

4.40e-0319982IPR023088
PathwayREACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT

ANK2 ANK3 COG7 SPTB ARF4 TUBB1

1.12e-05102706M27648
Pubmed

Cell organization, growth, and neural and cardiac development require αII-spectrin.

ANK2 ANK3 SPTB

2.90e-0610102322159418
Pubmed

[Hepatitis C virus induced hepatocellular carcinoma associated genes].

DEPDC5 MICA

8.52e-062102225764692
Pubmed

A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms.

DEPDC5 MICA

8.52e-062102230723271
Pubmed

Unusually rapid evolution of Neuroligin-4 in mice.

NLGN4Y NLGN4X

8.52e-062102218434543
Pubmed

Association of established hypothyroidism-associated genetic variants with Hashimoto's thyroiditis.

SH2B3 PDE8B

8.52e-062102228382505
Pubmed

Crinkly-tail, a mild skeletal mutant in the mouse.

TYRP1 DOCK7

8.52e-0621022536693
Pubmed

Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.

NLGN4Y NLGN4X

8.52e-062102223183221
Pubmed

Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.

NLGN4Y NLGN4X

8.52e-062102224855039
Pubmed

Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.

NLGN4Y NLGN4X

8.52e-062102237001827
Pubmed

Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.

NLGN4Y NLGN4X

8.52e-062102237080762
Pubmed

Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.

NLGN4Y NLGN4X

8.52e-062102229106499
Pubmed

Genetic spina bifida occulta in the mouse.

TYRP1 DOCK7

8.52e-0621022782223
Pubmed

Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.

NLGN4Y NLGN4X

8.52e-062102226456829
Pubmed

The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes.

ANK2 ANK3

8.52e-062102211781319
Pubmed

Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.

NLGN4Y NLGN4X

8.52e-062102224104404
Pubmed

Structural basis of diverse membrane target recognitions by ankyrins.

ANK2 ANK3

8.52e-062102225383926
Pubmed

Polysyndactyly, a new mutant gene in the mouse.

TYRP1 DOCK7

8.52e-06210224309830
Pubmed

A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.

NLGN4Y NLGN4X

8.52e-062102232243781
Pubmed

Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.

NLGN4Y NLGN4X

8.52e-062102222989184
Pubmed

Linkage analysis of the murine interferon alpha locus (Ifa) on chromosome 4.

TYRP1 DOCK7

8.52e-06210223475376
Pubmed

DDB2 is involved in ubiquitination and degradation of PAQR3 and regulates tumorigenesis of gastric cancer cells.

DDB2 PAQR3

8.52e-062102226205499
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ANK2 ANK3 KDM4C CORO1C SPTB LAMB1 NCBP1 NBEA BTBD2 ZNF365 ZNF785 TPP1 PPME1 VARS1

2.36e-0512851021435914814
Pubmed

Cloning of the mouse laminin alpha 4 cDNA. Expression in a subset of endothelium.

LAMB1 KDR

2.55e-05310229219532
Pubmed

Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.

NLGN4Y NLGN4X

2.55e-053102232011705
Pubmed

The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.

ANK2 ANK3

2.55e-053102215611082
Pubmed

Human ankyrins and their contribution to disease biology: An update.

ANK2 ANK3

2.55e-053102233410423
Pubmed

Analysis of the neuroligin 4Y gene in patients with autism.

NLGN4Y NLGN4X

2.55e-053102218628683
Pubmed

Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammation.

DPP4 FPGS

2.55e-053102216059892
Pubmed

WHIRLER MICE: A RECESSIVE BEHAVIOR MUTATION IN LINKAGE GROUP VIII.

TYRP1 DOCK7

2.55e-053102214098314
Pubmed

Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.

NLGN4Y NLGN4X

2.55e-053102221282647
Pubmed

A new genetic locus mapped from behavioral variation in mice: audiogenic seizure prone (ASP).

TYRP1 DOCK7

2.55e-05310225527661
Pubmed

Ankyrin-dependent Na+ channel clustering prevents neuromuscular synapse fatigue.

ANK2 ANK3

2.55e-053102234289389
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

KRT84 CORO1C BTBD2 PGD DDB2 ARF4 SHKBP1 KLHL15 DOCK7 NUP188 TAF5L VARS1

3.94e-0510051021219615732
Pubmed

Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.

NLGN4Y NLGN4X

5.09e-054102212669065
Pubmed

Homodimerization and isoform-specific heterodimerization of neuroligins.

NLGN4Y NLGN4X

5.09e-054102222671294
Pubmed

Ultrasonic vocalizations in mouse models for speech and socio-cognitive disorders: insights into the evolution of vocal communication.

NLGN4Y NLGN4X

5.09e-054102220579107
Pubmed

Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells.

SPTB LAMB1

5.09e-05410228098844
Pubmed

Molecular architecture of the αβ T cell receptor-CD3 complex.

TRB CD3D

5.09e-054102225422432
Pubmed

Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism.

DDB2 PAQR3

5.09e-054102235755276
Pubmed

Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.

TRB CD3D

5.09e-054102226109064
Pubmed

Polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with chronic hepatitis C-related hepatocellular carcinoma.

DEPDC5 MICA

5.09e-054102228928439
Pubmed

Analysis of four neuroligin genes as candidates for autism.

NLGN4Y NLGN4X

5.09e-054102216077734
Pubmed

Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.

NLGN4Y NLGN4X

5.09e-054102217292328
Pubmed

Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes.

ANK2 SPTB

5.09e-054102214593108
Pubmed

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum.

CD3D SYVN1

5.09e-054102214593114
Pubmed

Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch.

WNT5A PIEZO1

5.09e-054102230979871
Pubmed

Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells.

KDM4C KDR

5.09e-054102226120059
Pubmed

Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin.

PIEZO1 KDR

5.09e-054102237117774
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

TCTN3 ANK2 PIEZO1 SPTB NCBP1 CPS1 ZNF785 HERC2P3 STK16 NLGN4X ZNF808 NUP188 B4GALNT3

5.68e-0512151021315146197
Pubmed

Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.

ARF4 UBE3D TMEM131L DEPDC5

5.83e-0571102436305789
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

TCTN3 PTPMT1 LAMB1 CPS1 MYORG ARF4 TPP1 TMEM131L VARS1

8.28e-05613102922268729
Pubmed

CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.

ANK2 ANK3

8.47e-055102225950943
Pubmed

Change in expression pattern of TCR-CD3 complex in patients with multiple myeloma.

TRB CD3D

8.47e-055102221669053
Pubmed

Expression of laminin and nidogen genes during the postimplantation development of the mouse placenta.

LAMB1 TYRP1

8.47e-05510228286607
Pubmed

A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor.

TRB CD3D

8.47e-055102217023417
Pubmed

DBZ regulates cortical cell positioning and neurite development by sustaining the anterograde transport of Lis1 and DISC1 through control of Ndel1 dual-phosphorylation.

ZNF365 PAFAH1B1

8.47e-055102225698733
Pubmed

Glial ankyrins facilitate paranodal axoglial junction assembly.

ANK2 ANK3

8.47e-055102225362471
Pubmed

Wnt inhibition promotes vascular specification of embryonic cardiac progenitors.

WNT5A KDR

8.47e-055102229217753
Pubmed

Neuroligins and neurexins link synaptic function to cognitive disease.

NLGN4Y NLGN4X

8.47e-055102218923512
Pubmed

Synapse formation: if it looks like a duck and quacks like a duck ...

NLGN4Y NLGN4X

8.47e-055102210996085
Pubmed

An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.

TRB CD3D

8.47e-055102219056690
Pubmed

An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan.

ANK2 ANK3

8.47e-055102219109891
Pubmed

Combination of DPP-4 inhibitor and PPARγ agonist exerts protective effects on pancreatic β-cells in diabetic db/db mice through the augmentation of IRS-2 expression.

DPP4 DOCK7

8.47e-055102226116826
Pubmed

Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.

NLGN4Y NLGN4X

8.47e-055102237865312
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

SLC5A10 ANK3 PDE1B COG7 CUBN CPS1 STK16 TPP1 WDR89 KDR RNF41 ZNF79 DEPDC5

1.06e-0412931021315342556
Pubmed

Proteome-scale Binary Interactomics in Human Cells.

SHKBP1 RNF41 HOMER2

1.25e-0433102327803151
Pubmed

The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?

NLGN4Y NLGN4X

1.27e-046102221838267
Pubmed

Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.

NLGN4Y NLGN4X

1.27e-046102229724786
Pubmed

Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis.

FPGS ABCC2

1.27e-046102218381794
Pubmed

In vivo assembly of the axon initial segment in motor neurons.

ANK2 ANK3

1.27e-046102223728480
Pubmed

RNF41 interacts with the VPS52 subunit of the GARP and EARP complexes.

RNF41 HOMER2

1.27e-046102228542518
Pubmed

Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.

TMEM204 KDR

1.27e-046102220439428
Pubmed

Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice.

ANK2 ANK3

1.77e-04710227495297
Pubmed

An Analysis of Translocations in the Mouse.

TYRP1 DOCK7

1.77e-047102217247190
Pubmed

Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively.

SPTB LAMB1

1.77e-04710228276400
Pubmed

Characterization of WDR20: A new regulator of the ERAD machinery.

CD3D SYVN1

1.77e-047102229655804
Pubmed

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo.

WNT5A LRP5

1.77e-047102219056682
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

ANK2 ANK3 NLGN4Y NBEA NLGN4X HOMER2

1.86e-04281102628706196
Pubmed

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.

CORO1C PAFAH1B1 WDR89

2.24e-0440102329078390
Pubmed

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

TCTN3 ANK3 CUBN ZNF365 SLC39A12 ARL3 ABCC2

2.29e-04415102716385451
Pubmed

Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.

NLGN4Y NLGN4X

2.36e-048102230871858
Pubmed

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

WNT5A LRP5

2.36e-048102220093360
Pubmed

Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes.

DPP4 TMEM204

2.36e-048102218246200
Pubmed

Cdx2 determines the fate of postnatal intestinal endoderm.

MUC6 ATP4A

2.36e-048102222190642
Pubmed

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.

ANK2 ANK3 CORO1C PGD ARF4 TTC7A ARL3 PAFAH1B1

2.45e-04558102835063084
Pubmed

Large-scale concatenation cDNA sequencing.

ANK2 COG7 ABCB6 BTBD2 SHKBP1 ARL3 RNF41 CLBA1

2.76e-0456810289110174
Pubmed

A "double adaptor" method for improved shotgun library construction.

ANK2 COG7 ABCB6 BTBD2 SHKBP1 ARL3 RNF41 CLBA1

2.96e-0457410288619474
Pubmed

CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome.

ERCC6 DDB2

3.03e-049102216751180
Pubmed

Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.

NLGN4Y NLGN4X

3.03e-049102223010509
Pubmed

KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.

DPP4 KDR

3.03e-049102223746980
Pubmed

Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse.

PGD TTC7A

3.03e-049102215155459
Pubmed

Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD.

ADAMTS3 KDR

3.03e-049102227159393
Pubmed

Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.

ANK2 ANK3

3.03e-049102229867141
Pubmed

Microglia ablation alleviates myelin-associated catatonic signs in mice.

NLGN4Y NLGN4X

3.03e-049102229252214
Pubmed

SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells.

CD3D SYVN1

3.03e-049102217502376
Pubmed

Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis.

WNT5A KDR

3.03e-049102211092808
Pubmed

Switching of α-Catenin From Epithelial to Neuronal Type During Lens Epithelial Cell Differentiation.

ANK2 SPTB

3.03e-049102228692740
Pubmed

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.

WNT5A LRP5

3.77e-0410102215143170
Pubmed

Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.

SH2B3 MICA

3.77e-0410102223417110
Pubmed

Inherited ACTH insensitivity illuminates the mechanisms of ACTH action.

RTP4 RTP3

3.77e-0410102216271481
Cytoband3p21.3

CCR9 RTP3 DLEC1

3.16e-045910233p21.3
Cytoband2q35

CPS1 STK11IP STK16

7.45e-047910232q35
Cytoband12p13.33

CACNA2D4 B4GALNT3

8.15e-0419102212p13.33
Cytoband9q34.1

FPGS NCBP1

8.15e-041910229q34.1
GeneFamilyWD repeat domain containing

CORO1C NBEA DDB2 SHKBP1 PAFAH1B1 WDR89 TAF5L

4.65e-05262667362
GeneFamilyZinc fingers 3CxxC-type|Receptor transporter proteins

RTP4 RTP3

1.30e-045662719
GeneFamilyZinc fingers 3CxxC-type|Receptor transporter proteins

RTP4 RTP3

3.62e-048662137
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANK2 PDE1B LAMB1 NBEA NWD2 HMCN2

3.35e-061771026bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-Microfold_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PKDCC SLC7A8 AKR1B10 RFLNA MUC6 HOMER2

4.46e-0618610266d8dd6d0403d149cb6edb346581fe6c248036785
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC|GW10 / Sample Type, Dataset, Time_group, and Cell type.

LAMB1 CUBN ZNF79 DDX60L TAF5L

2.55e-0515110254533bccc996395f74b16af939ce79b6fe253c073
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related|GW10 / Sample Type, Dataset, Time_group, and Cell type.

LAMB1 CUBN ZNF79 DDX60L TAF5L

2.55e-051511025edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCTN3 FPGS NBEA SLC7A8 CD3D

3.79e-051641025d8ecb3de6e34f5f574449e3d2f26fa0b2b7e84e8
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DPP4 CD3D WDR89 DLEC1 ABCC2

4.02e-051661025ceb0a48c0d853448fd45ac31dde046df9a178571
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DPP4 ANK3 SPTB ZNF365 CD3D

4.25e-05168102507be11b6f0f37106e219692db5795c6dd32807c9
ToppCellInfluenza_Severe-CD4+_Tcm|Influenza_Severe / Disease group and Cell class

DPP4 ANK3 TMEM204 PHYHIP CD3D

4.76e-05172102547865a04968ca28c6ff125159d9a23e37c8b8af1
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANK2 WNT5A LAMB1 DIPK2A RFLNA

4.89e-051731025f9d6e892d66f9b94e4d5beb9f5dec9b606bc868a
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANK2 WNT5A LAMB1 DIPK2A RFLNA

4.89e-051731025cbd65dd5b01cc959e3ccbc89330ddd0122296ea3
ToppCelldroplet-Heart-4Chambers-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM204 DIPK2A WDR89 LRP5 KDR

4.89e-0517310259a04271c51fae34f547db3206f9ff5857686e45c
ToppCell10x3'2.3-week_17-19-Lymphocytic_T-T_NK-CD8_T_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

DPP4 TMEM204 CCR9 RTP4 CD3D

5.02e-051741025fee2ee3e888ce71f9f3f05d7dc8aaa9549480205
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

WNT5A NBEA PDE8B KDR B4GALNT3

5.45e-051771025779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

WNT5A NBEA PDE8B KDR B4GALNT3

5.45e-0517710250f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCellSevere-CD4+_T_activated|World / Disease group and Cell class

ANK3 NLGN4Y NBEA RTP4 DDX60L

5.60e-051781025ef6111238703579a34bd6948bd9d4ca6b7e16063
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM204 DIPK2A WDR89 LRP5 KDR

5.60e-05178102593ce73f8bcec63ebf86fabb546f88400e8f06465
ToppCell15-Distal-Epithelial-Epithelial|Distal / Age, Tissue, Lineage and Cell class

ANK3 TUBB1 NLGN4X KLHL15 ZNF79

5.90e-05180102599e2db9ad8e09fedc3542233553acece69f579f1
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

WNT5A NBEA PDE8B B4GALNT3 HOMER2

6.22e-0518210253f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC5A10 ANK2 CUBN SLC7A8 ABCC2

6.38e-051831025facd6dbe0851b537d70a899ac7485714ab27d071
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_EGR3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IL17REL ADAMTS3 ZNF365 DIPK2A NWD2

6.89e-05186102577b09af860183606a1775eba921e2071e4a7dd4e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DPP4 ANK3 TMEM204 CD3D KDR

6.89e-051861025c793a3d5709ad504c12fc3b2337746d90236d3ca
ToppCellwk_20-22-Hematologic_Lymphocytic-B-pre-B-I_cell|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FPGS TTC7A TMEM131L RNF41 SYVN1

6.89e-051861025d708e8f3e371c8249e8e8f7458b352af7be412e6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC5A10 ANK2 CUBN SLC7A8 ABCC2

7.43e-051891025204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC5A10 ANK2 CUBN SLC7A8 ABCC2

7.43e-05189102513fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

ANK3 WNT5A NBEA B4GALNT3 HOMER2

7.43e-05189102584d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADAMTS3 TMEM204 LAMB1 CUBN KDR

7.62e-05190102506bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL17REL FAM83E NBEA PDE8B MUC6

7.62e-05190102523f2ac4da431211084bb6ab0494c2e0b69547cb6
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

ANK3 FAM83E NBEA B4GALNT3 HOMER2

7.62e-05190102551ca9ef4df3220487152fcf684147730637c7cc1
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL17REL FAM83E NBEA PDE8B MUC6

7.62e-0519010253c337374d89e69cc0a78e65a4a7e21db7b050fcd
ToppCell5'-Adult-LymphNode-Epithelial-goblet-BEST2+_Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NBEA MYORG TMEM131L ZNF808 MICA

7.81e-051911025e5c41c3054ead03597c136eaccaf9822e6bb9d1a
ToppCell5'-Adult-LymphNode-Epithelial-goblet|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NBEA MYORG TMEM131L ZNF808 MICA

7.81e-0519110257e24175c7fabe5ea0b22b73173da4c3a666e5eb8
ToppCelldroplet-Kidney-nan-3m-Endothelial-fenestrated_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM204 RTP4 RTP3 KDR RFLNA

8.00e-05192102585be54c2cba8eab4c6ef2a85a526f7a9db4cfe73
ToppCelldroplet-Kidney-nan-3m-Endothelial-Pecam____fenestrated_capillary_endothelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM204 RTP4 RTP3 KDR RFLNA

8.00e-05192102531a9142d97b690992aabee1a181650deb1a44253
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TMEM204 LAMB1 LHX6 MYORG KDR

8.61e-0519510254658fb197657d7692ee344ae76b11b0210c418ba
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ANK3 WNT5A NBEA B4GALNT3 HOMER2

8.61e-051951025dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SH2B3 PLEKHG2 SLC7A8 SLC16A6 TPP1

8.61e-0519510250ec1b572bbb92b6da3440139366a4c1743b1ad92
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SH2B3 PLEKHG2 SHKBP1 TTC7A TPP1

9.03e-0519710258c24ffcd417da42fa9bcbe6bd0325360e537303f
ToppCellcontrol-MAIT|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DPP4 TMEM204 PKDCC CD3D B4GALNT3

9.25e-05198102513955a4026c97e11d94973ac87bf018f64a2616c
Diseasereticulocyte measurement

SH2B3 CORO1C PIEZO1 SPTB ABCB6 STK16 TUBB1 TMEM131L LRP5 DEPDC5 MICA RFLNA PAQR3

5.68e-05105310013EFO_0010700
DiseasePachygyria

LAMB1 PAFAH1B1

1.13e-0451002C0266483
DiseaseAgyria

LAMB1 PAFAH1B1

1.13e-0451002C1879312
Disease1,5 anhydroglucitol measurement

SLC5A10 PCDHA11 PCDHA7

1.29e-04291003EFO_0008009
DiseaseMalformation of cortical development

LAMB1 PAFAH1B1

1.69e-0461002cv:C1955869
DiseaseLissencephaly

LAMB1 PAFAH1B1

1.69e-0461002cv:C0266463
DiseaseLissencephaly

LAMB1 PAFAH1B1

1.69e-0461002C0266463
Diseasemelanoma

KDM4C CUBN DDB2 TYRP1 SLC39A12 AKR1B10

2.05e-042481006C0025202
Diseasereticulocyte count

SH2B3 CORO1C PIEZO1 SPTB ABCB6 STK16 TUBB1 TMEM131L LRP5 DEPDC5 RFLNA PAQR3

2.19e-04104510012EFO_0007986
Diseasevisceral adipose tissue measurement, body mass index

PCDHA11 PCDHA7 MICA RFLNA

2.23e-04871004EFO_0004340, EFO_0004765
Diseaseautistic disorder (is_implicated_in)

KDM4C LAMB1 NLGN4X

3.94e-04421003DOID:12849 (is_implicated_in)
DiseaseX-21467 measurement

CPS1 ABCC2

4.03e-0491002EFO_0020007
Diseasebeta-2 microglobulin measurement

SH2B3 MICA

6.13e-04111002EFO_0005197
DiseaseCleft palate, tobacco smoke exposure measurement, cleft lip, parental genotype effect measurement

ANK3 SHKBP1

6.13e-04111002EFO_0003959, EFO_0005939, EFO_0009115, HP_0000175
DiseaseColorectal Carcinoma

ERCC6 ANK2 FPGS ABCB6 CUBN NLGN4X AKR1B10 KDR ABCC2

6.44e-047021009C0009402
Diseaseplatelet measurement

SH2B3 CPS1 TUBB1 DOCK7 TMEM131L MICA

7.26e-043151006EFO_0005036
Diseasebilirubin measurement

SH2B3 PIEZO1 SPTB CPS1 SHKBP1 DOCK7 ABCC2

7.81e-044421007EFO_0004570
DiseaseDisorder of eye

TCTN3 TYRP1 CACNA2D4 TPP1 LRP5

7.91e-042121005C0015397
Diseaseplatelet component distribution width

SH2B3 BTBD2 CUBN CPS1 TUBB1 DOCK7 TMEM131L MICA DLEC1

1.07e-037551009EFO_0007984
Diseasebasophil measurement

SLC7A8 MICA HECA

1.12e-03601003EFO_0803539
Diseasecholesterol to total lipids in medium HDL percentage

DDB2 DOCK7 RFLNA

1.12e-03601003EFO_0022237
Diseaseureidopropionic acid measurement

CPS1 OTOG

1.32e-03161002EFO_0010542
Diseaseserum non-albumin protein measurement

SH2B3 CORO1C PKDCC CPS1 SLC7A8 TMEM131L

1.46e-033611006EFO_0004568
DiseaseVan Buchem disease

LRP5 KDR

1.50e-03171002C0432272
DiseaseGrand Mal Status Epilepticus

ANK3 CCR9 ABCC2

1.55e-03671003C0311335
DiseaseStatus Epilepticus, Subclinical

ANK3 CCR9 ABCC2

1.55e-03671003C0751522
DiseaseSimple Partial Status Epilepticus

ANK3 CCR9 ABCC2

1.55e-03671003C0751524
DiseaseNon-Convulsive Status Epilepticus

ANK3 CCR9 ABCC2

1.55e-03671003C0751523
DiseasePetit mal status

ANK3 CCR9 ABCC2

1.55e-03671003C0270823
DiseaseComplex Partial Status Epilepticus

ANK3 CCR9 ABCC2

1.55e-03671003C0393734
DiseaseStatus Epilepticus

ANK3 CCR9 ABCC2

1.61e-03681003C0038220
Diseasecitrulline measurement

CPS1 HMCN2

2.08e-03201002EFO_0009777
DiseaseAutoimmune Hepatitis

SH2B3 MICA

2.29e-03211002EFO_0005676
Diseasecholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

DDB2 DOCK7 MICA RFLNA ATP4A

2.52e-032761005EFO_0004612, EFO_0020943
DiseaseColorectal Neoplasms

FPGS ABCB6 AKR1B10 KDR ABCC2

2.56e-032771005C0009404

Protein segments in the cluster

PeptideGeneStartEntry
FTRFWDSVNRSVRQQ

AMER3

306

Q8N944
DRVFVNCNTSITWVE

CD3D

31

P04234
DWTAFQNSIRIIATC

COG7

461

P83436
VFEDWCGSSIQQLRR

B4GALNT3

126

Q6L9W6
HTIRDRVWQIQSCSA

ARL3

146

P36405
DIRVSRVTWDSSFCA

CORO1C

26

Q9ULV4
RVTWDSSFCAVNPRF

CORO1C

31

Q9ULV4
ERSQVRSAAQQSTWR

ABCB6

226

Q9NP58
NCQDSWRRAVSTGVQ

PGD

401

P52209
SFNRNWRACNVLQSS

AKR1B10

291

O60218
FVVSLCEENASRVWR

NWD2

1411

Q9ULI1
SCSNDQTVRVWVVAT

PAFAH1B1

251

P43034
SWAVFTAAIISRVQC

PPME1

91

Q9Y570
TQQWQRLRSIIFCSV

PAQR3

196

Q6TCH7
NCSSVRWATRVQDIF

SLC7A8

176

Q9UHI5
TWVATRICQGEEQRF

MICA

266

Q29983
NECVSFTTNVSARFW

ANK2

1286

Q01484
FTTNVSARFWLIDCR

ANK2

1291

Q01484
SARFWLIDCRQIQES

ANK2

1296

Q01484
NIVCRWNDNSVVTVA

ERCC6

876

P0DP91
GSWSFSQQRRQRVCS

PCDHA7

746

Q9UN72
INRDNRLVTFWTSCL

DEPDC5

1581

O75140
WAERKCSVINSQTFA

MUC6

1056

Q6W4X9
SWSYSQQRRQRVCSE

PCDHA11

746

Q9Y5I1
RCQEQAQTTDWRATL

PLA2G12A

21

Q9BZM1
CWHQVTRTRFSTRNV

C22orf46

56

C9J442
QNLNRFRANSVSCWS

KRT84

26

Q9NSB2
WVVNAVNCSLFSAVR

MAF1

126

Q9H063
CAAVANWIFSSELSR

NCBP1

616

Q09161
TQETQCQSVWVARAS

IL17REL

51

Q6ZVW7
EWESSILVQFNCIGR

HECA

136

Q9UBI9
CWAENRVGRTQAVSF

HMCN2

4191

Q8NDA2
ASVEQWKRQFSICRD

HOMER2

206

Q9NSB8
RTLFWTCEATNTINV

LRP5

1036

O75197
QRACSRVITCSWIRN

DDX60L

311

Q5H9U9
RVITCSWIRNSDSFL

DDX60L

316

Q5H9U9
EVRDWLASTFTQQAR

PDE1B

96

Q01064
NCSETTLRAWFQVIE

PDE8B

591

O95263
NCAESTNFATVRWID

KDM4C

286

Q9H3R0
VTNSAWETFQRYRCL

LAMB1

726

P07942
TGLSRRVIQVWFQNC

LHX6

256

Q9UPM6
CSQKADTVFRLNWAT

DPP4

551

P27487
DTNQKCVFSWITSNR

ABCC2

1191

Q92887
LRVFASSDTINIWFC

DDB2

191

Q92466
RICVQNSTFSATWNR

MRPL37

201

Q9BZE1
ETRFLCNSSQEWKRL

PTPMT1

76

Q8WUK0
SWTGIRNATQFSAVC

NLGN4Y

96

Q8NFZ3
RSNTDCSWVIRVDRN

CUBN

1531

O60494
EFDWCAVSSIRTLRQ

CPS1

991

P31327
SRSLENVCRWASQQQ

ADAMTS3

326

O15072
QRTRRTQVVTNCWEN

KLHL15

456

Q96M94
CSGSVRESALQQAWF

DOCK7

996

Q96N67
LQRKFWAATRQCSTV

CACNA2D4

861

Q7Z3S7
TSWCRRFLNGQVVFE

DIPK2A

61

Q8NDZ4
GCISQAQWVSFTRRE

CCR9

336

P51686
DCVSFTTNVSARFWL

ANK3

1271

Q12955
TASSAQACVRWFRQA

FPGS

381

Q05932
RLFNAVVRWSEAECQ

BTBD2

281

Q9BX70
ECSINRFQQVESRWG

BTBD2

371

Q9BX70
WVDFGTCFVSQQRVR

DLEC1

1641

Q9Y238
WFSQQQTCPVDRSVV

RNF41

46

Q9H4P4
WDQTCFSARQLVEIF

SLC39A12

306

Q504Y0
SWTGIRNTTQFAAVC

NLGN4X

96

Q8N0W4
TFDQSSETWRALCRV

ATP4A

421

P20648
RRSVQLFCATNATWV

OTOG

2896

Q6ZRI0
FNESNSRISWIISIC

SLC16A6

56

O15403
QQWTFARFQCSSCSR

RTP3

46

Q9BQQ7
SSCQRSWASAQVQIL

RTP4

56

Q96DX8
NVTRWFVTCVRQPEF

VARS1

186

P26640
DNSVRVWDIRNTYCS

TAF5L

531

O75529
FHTSCLRSWFQRQQT

SYVN1

311

Q86TM6
SRLESFWALRVVCQE

STK11IP

1041

Q8N1F8
AQCRAFVVTNQTTWT

PKDCC

451

Q504Y2
RQALTLQDWAAQRCT

STK16

181

O75716
SDINVRSWCIQESTR

TMEM131L

1251

A2VDJ0
CSFQSRWRRQVSGTV

FAM83E

221

Q2M2I3
VTVTCSRLFAVNRWH

NBEA

2616

Q8NFP9
RWTVQTCLTCQRSQR

RPP21

86

Q9H633
VCADNNHVRTWSVTR

SHKBP1

446

Q8TBC3
RARWTIEHTICNSQT

SHLD3

166

Q6ZNX1
LSVQTRNSSCFVEWI

TUBB1

331

Q9H4B7
EINNITCDSFRISWA

PHYHIP

11

Q92561
REQHRSWCTLGFVQS

HERC2P3

731

Q9BVR0
QSLRNRTWYVQATCA

ARF4

146

P18085
RLWSESRCQENFFLV

CLBA1

211

Q96F83
SVFSQWRVVCDSLED

TYRP1

281

P17643
NVAVGIWSSCRASRN

SLC5A10

31

A0PJK1
SRWFTASVQLQLCQD

RFLNA

191

Q6ZTI6
RSWFVQSVIAQCLVQ

UBE3D

246

Q7Z6J8
QVCDTAFTWNSQLAR

ZNF808

626

Q8N4W9
TERQVSRWFVQCLRE

NUP188

196

Q5SRE5
QAACSSIQEVRWCTR

SH2B3

251

Q9UQQ2
RRWNCSTVDNTSVFG

WNT5A

111

P41221
VCQFSRDASVAEAWL

SPTB

2011

P11277
CLSSRLRVSATFWQN

TRB

211

P0DTU4
VITCFERASWIAQVF

TTC7A

196

Q9ULT0
FTSNWVCQTLEDGRR

TMEM204

26

Q9BSN7
FRSCSEIRSAWQALE

PLEKHG2

761

Q9H7P9
QITITVSRCWNTERN

ZNF365

6

Q70YC4
CTARTELNVGIDFNW

KDR

246

P35968
LLCASQQWQVFSAER

PIEZO1

1106

Q92508
AATVRSFCWNVQDDS

WDR89

321

Q96FK6
VRSSSWVCVDNSVIF

TCTN3

126

Q6NUS6
SSVTVAFAQERWRCL

ZNF79

41

Q15937
IQSNAVRSARWLFET

XIRP1

261

Q702N8
IHRSCSERRAWQQAV

ZNF785

361

A8K8V0
TQDFLTCWLSIRQAE

TPP1

116

O14773
NISCFFRLVDRDSVW

MYORG

511

Q6NSJ0