Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	SH3 domain binding	WIPF1 SYNJ1 SYNJ2 SH3BP1 SHANK3 DNM2 SOS1	4.40e-06	143	92	7	GO:0017124
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	ACAP1 WASL PLEKHG3 ARHGEF5 DENND4B RIN2 SH3BP1 IQSEC1 FGD1 OPHN1 SOS1	2.13e-05	507	92	11	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	ACAP1 WASL PLEKHG3 ARHGEF5 DENND4B RIN2 SH3BP1 IQSEC1 FGD1 OPHN1 SOS1	2.13e-05	507	92	11	GO:0030695
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	PLEKHG3 ARHGEF5 DENND4B RIN2 IQSEC1 FGD1 SOS1	9.63e-05	231	92	7	GO:0005085
GeneOntologyMolecularFunction	enzyme regulator activity	NCOR1 MMP24 ACAP1 WASL PLEKHG3 ARHGEF5 DENND4B RIN2 SH3BP1 IQSEC1 FGD1 WFDC1 ITIH6 B3GAT3 MAPK8IP2 OPHN1 SOS1	2.32e-04	1418	92	17	GO:0030234
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	SYNJ1 SYNJ2	3.11e-04	6	92	2	GO:0043813
GeneOntologyMolecularFunction	transferase activity, transferring sulphur-containing groups	CTU2 NDST2 GAL3ST3 HS6ST3	3.79e-04	74	92	4	GO:0016782
GeneOntologyMolecularFunction	cytoskeletal protein binding	TPR WASL KCNA5 WIPF1 XIRP2 PLEKHG3 KIF12 RELA SHANK3 MAPK8IP2 OPHN1 KIFC1 DNM2 KLHL17	4.87e-04	1099	92	14	GO:0008092
GeneOntologyMolecularFunction	inositol-1,4,5-trisphosphate 5-phosphatase activity	SYNJ1 SYNJ2	5.77e-04	8	92	2	GO:0052658
GeneOntologyMolecularFunction	protein domain specific binding	NCOR1 SORBS2 WIPF1 SYNJ1 SYNJ2 SLC34A1 SH3BP1 RELA SHANK3 DNM2 KLHL17 SOS1	6.71e-04	875	92	12	GO:0019904
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	SYNJ1 SYNJ2	9.22e-04	10	92	2	GO:0004439
GeneOntologyMolecularFunction	phosphatidylinositol phosphate 4-phosphatase activity	SYNJ1 SYNJ2	9.22e-04	10	92	2	GO:0034596
GeneOntologyMolecularFunction	actinin binding	KCNA5 XIRP2 RELA	1.02e-03	43	92	3	GO:0042805
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	SYNJ1 SYNJ2	1.12e-03	11	92	2	GO:0052629
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate phosphatase activity	SYNJ1 SYNJ2	1.34e-03	12	92	2	GO:0106019
GeneOntologyMolecularFunction	phosphatidylinositol phosphate 5-phosphatase activity	SYNJ1 SYNJ2	1.58e-03	13	92	2	GO:0034595
GeneOntologyMolecularFunction	inositol trisphosphate phosphatase activity	SYNJ1 SYNJ2	1.84e-03	14	92	2	GO:0046030
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate phosphatase activity	SYNJ1 SYNJ2	1.84e-03	14	92	2	GO:0004438
GeneOntologyMolecularFunction	sulfotransferase activity	NDST2 GAL3ST3 HS6ST3	2.09e-03	55	92	3	GO:0008146
GeneOntologyMolecularFunction	phosphatidylinositol monophosphate phosphatase activity	SYNJ1 SYNJ2	2.12e-03	15	92	2	GO:0052744
GeneOntologyMolecularFunction	heparan sulfate sulfotransferase activity	NDST2 HS6ST3	2.12e-03	15	92	2	GO:0034483
GeneOntologyMolecularFunction	protein kinase binding	TPR KCNA5 RHOV CDK13 DACT3 IQSEC1 FAM83G MAP3K11 RELA MAPK8IP2 DNM2	2.22e-03	873	92	11	GO:0019901
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate phosphatase activity	SYNJ1 SYNJ2	2.42e-03	16	92	2	GO:0106018
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	HEG1 PLEKHG3 ARHGEF5 DENND4B SH3BP1 IQSEC1 FGD1 PRAG1 OPHN1 DNM2 SOS1	2.47e-07	333	91	11	GO:0051056
GeneOntologyBiologicalProcess	small GTPase-mediated signal transduction	HEG1 RHOV PLEKHG3 ARHGEF5 DENND4B RIN2 SH3BP1 IQSEC1 FGD1 PRAG1 OPHN1 DNM2 SOS1	6.69e-07	538	91	13	GO:0007264
GeneOntologyBiologicalProcess	negative regulation of membrane tubulation	WASL DNM2	1.93e-05	2	91	2	GO:1903526
GeneOntologyBiologicalProcess	actin filament-based process	WASL GRID2IP KCNA5 WIPF1 XIRP2 RHOV ARHGEF5 SH3BP1 IQSEC1 FGD1 SHANK3 OPHN1 DNM2 KLHL17	4.43e-05	912	91	14	GO:0030029
GeneOntologyBiologicalProcess	actin cytoskeleton organization	WASL GRID2IP WIPF1 XIRP2 RHOV ARHGEF5 SH3BP1 IQSEC1 FGD1 SHANK3 OPHN1 DNM2 KLHL17	4.97e-05	803	91	13	GO:0030036
GeneOntologyBiologicalProcess	regulation of stem cell differentiation	SETD1A ITCH CDK13 SIRT6 MEN1	7.72e-05	99	91	5	GO:2000736
GeneOntologyBiologicalProcess	positive regulation of protein export from nucleus	TPR WIPF1 SIRT6	1.20e-04	22	91	3	GO:0046827
GeneOntologyCellularComponent	glutamatergic synapse	VGF WASL GRID2IP CELSR3 SYNJ1 ICAM5 IQSEC1 RELA GRIK4 SHANK3 OPHN1 DNM2 KLHL17	5.18e-05	817	91	13	GO:0098978
GeneOntologyCellularComponent	postsynaptic density, intracellular component	GRID2IP IQSEC1 SHANK3 DNM2	6.13e-05	49	91	4	GO:0099092
GeneOntologyCellularComponent	postsynaptic specialization, intracellular component	GRID2IP IQSEC1 SHANK3 DNM2	1.04e-04	56	91	4	GO:0099091
GeneOntologyCellularComponent	phagocytic cup	SH3BP1 DNM2 PEAR1	3.28e-04	31	91	3	GO:0001891
GeneOntologyCellularComponent	lamellipodium	WASL SORBS2 SH3BP1 FGD1 DNM2 PEAR1	5.08e-04	230	91	6	GO:0030027
GeneOntologyCellularComponent	postsynaptic density	GRID2IP CELSR3 IQSEC1 GRIK4 SHANK3 MAPK8IP2 DNM2 KLHL17	7.85e-04	451	91	8	GO:0014069
GeneOntologyCellularComponent	asymmetric synapse	GRID2IP CELSR3 IQSEC1 GRIK4 SHANK3 MAPK8IP2 DNM2 KLHL17	1.13e-03	477	91	8	GO:0032279
GeneOntologyCellularComponent	ESCRT I complex	VPS37D MVB12B	1.20e-03	12	91	2	GO:0000813
GeneOntologyCellularComponent	microfibril	THSD4 LTBP4	1.42e-03	13	91	2	GO:0001527
GeneOntologyCellularComponent	cell leading edge	WASL SORBS2 WIPF1 SYNJ2 SH3BP1 FGD1 DNM2 PEAR1	1.52e-03	500	91	8	GO:0031252
GeneOntologyCellularComponent	postsynaptic specialization	GRID2IP CELSR3 IQSEC1 GRIK4 SHANK3 MAPK8IP2 DNM2 KLHL17	1.58e-03	503	91	8	GO:0099572
GeneOntologyCellularComponent	supramolecular fiber	THSD4 SORBS2 KCNA5 WIPF1 SYNJ1 XIRP2 SYNJ2 KIF12 MAP3K11 TTLL10 LTBP4 KIFC1 DNM2	1.74e-03	1179	91	13	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	THSD4 SORBS2 KCNA5 WIPF1 SYNJ1 XIRP2 SYNJ2 KIF12 MAP3K11 TTLL10 LTBP4 KIFC1 DNM2	1.85e-03	1187	91	13	GO:0099081
GeneOntologyCellularComponent	neuron to neuron synapse	GRID2IP CELSR3 IQSEC1 GRIK4 SHANK3 MAPK8IP2 DNM2 KLHL17	2.01e-03	523	91	8	GO:0098984
Domain	-	ACAP1 WASL IRS4 PLEKHG3 ARHGEF5 IQSEC1 FGD1 MAPK8IP2 PLEKHH3 OPHN1 DNM2 SOS1	3.77e-07	391	90	12	2.30.29.30
Domain	PH	ACAP1 IRS4 PLEKHG3 ARHGEF5 IQSEC1 FGD1 PLEKHH3 OPHN1 DNM2 SOS1	9.11e-07	278	90	10	SM00233
Domain	PH_dom-like	ACAP1 WASL IRS4 PLEKHG3 ARHGEF5 IQSEC1 FGD1 MAPK8IP2 PLEKHH3 OPHN1 DNM2 SOS1	9.33e-07	426	90	12	IPR011993
Domain	PH_DOMAIN	ACAP1 IRS4 PLEKHG3 ARHGEF5 IQSEC1 FGD1 PLEKHH3 OPHN1 DNM2 SOS1	9.41e-07	279	90	10	PS50003
Domain	PH_domain	ACAP1 IRS4 PLEKHG3 ARHGEF5 IQSEC1 FGD1 PLEKHH3 OPHN1 DNM2 SOS1	9.72e-07	280	90	10	IPR001849
Domain	DUF1866	SYNJ1 SYNJ2	2.30e-05	2	90	2	IPR015047
Domain	DUF1866	SYNJ1 SYNJ2	2.30e-05	2	90	2	SM01165
Domain	DUF1866	SYNJ1 SYNJ2	2.30e-05	2	90	2	PF08952
Domain	PH	ACAP1 PLEKHG3 ARHGEF5 FGD1 OPHN1 DNM2 SOS1	1.20e-04	229	90	7	PF00169
Domain	MABP	DENND4B MVB12B	1.37e-04	4	90	2	IPR023341
Domain	MABP	DENND4B MVB12B	1.37e-04	4	90	2	PS51498
Domain	NUT	NUTM2B NUTM2A	2.27e-04	5	90	2	IPR024310
Domain	NUT_N	NUTM2B NUTM2A	2.27e-04	5	90	2	IPR024309
Domain	NUT	NUTM2B NUTM2A	2.27e-04	5	90	2	PF12881
Domain	Syja_N	SYNJ1 SYNJ2	2.27e-04	5	90	2	PF02383
Domain	SAC	SYNJ1 SYNJ2	2.27e-04	5	90	2	PS50275
Domain	SAC_dom	SYNJ1 SYNJ2	2.27e-04	5	90	2	IPR002013
Domain	DH_1	PLEKHG3 ARHGEF5 FGD1 SOS1	2.42e-04	63	90	4	PS00741
Domain	RhoGEF	PLEKHG3 ARHGEF5 FGD1 SOS1	3.24e-04	68	90	4	SM00325
Domain	RhoGEF	PLEKHG3 ARHGEF5 FGD1 SOS1	3.63e-04	70	90	4	PF00621
Domain	DH_2	PLEKHG3 ARHGEF5 FGD1 SOS1	3.63e-04	70	90	4	PS50010
Domain	DH-domain	PLEKHG3 ARHGEF5 FGD1 SOS1	3.83e-04	71	90	4	IPR000219
Domain	-	PLEKHG3 ARHGEF5 FGD1 SOS1	3.83e-04	71	90	4	1.20.900.10
Domain	SH3_9	SORBS2 ARHGEF5 MAP3K11 MAPK8IP2	5.48e-04	78	90	4	PF14604
Domain	Laminin_EGF	CELSR3 SCARF2 PEAR1	6.33e-04	35	90	3	PF00053
Domain	EGF_Lam	CELSR3 SCARF2 PEAR1	6.33e-04	35	90	3	SM00180
Domain	SH3_2	SORBS2 ARHGEF5 MAP3K11 SHANK3	7.92e-04	86	90	4	IPR011511
Domain	SH3_2	SORBS2 ARHGEF5 MAP3K11 SHANK3	7.92e-04	86	90	4	PF07653
Domain	Laminin_EGF	CELSR3 SCARF2 PEAR1	8.08e-04	38	90	3	IPR002049
Domain	GDS_CDC24_CS	ARHGEF5 FGD1 SOS1	8.72e-04	39	90	3	IPR001331
Domain	IPPc	SYNJ1 SYNJ2	1.01e-03	10	90	2	IPR000300
Domain	IPPc	SYNJ1 SYNJ2	1.01e-03	10	90	2	SM00128
Domain	PLAC	THSD4 ADAMTSL4	2.01e-03	14	90	2	PF08686
Domain	WH2	WASL WIPF1	2.01e-03	14	90	2	SM00246
Domain	WH2	WASL WIPF1	2.64e-03	16	90	2	PF02205
Domain	PLAC	THSD4 ADAMTSL4	3.72e-03	19	90	2	PS50900
Domain	BAR	ACAP1 SH3BP1	3.72e-03	19	90	2	PS51021
Domain	PLAC	THSD4 ADAMTSL4	3.72e-03	19	90	2	IPR010909
Domain	SH3	SORBS2 ARHGEF5 MAP3K11 SHANK3 MAPK8IP2	3.92e-03	216	90	5	SM00326
Domain	SH3	SORBS2 ARHGEF5 MAP3K11 SHANK3 MAPK8IP2	3.92e-03	216	90	5	PS50002
Domain	SH3_domain	SORBS2 ARHGEF5 MAP3K11 SHANK3 MAPK8IP2	4.23e-03	220	90	5	IPR001452
Domain	WH2_dom	WASL WIPF1	4.54e-03	21	90	2	IPR003124
Domain	RRM_dom	SETD1A RBMXL2 SYNJ1 SYNJ2 PABPN1	4.83e-03	227	90	5	IPR000504
Domain	RRM	SETD1A RBMXL2 SYNJ1 SYNJ2 PABPN1	5.10e-03	230	90	5	PS50102
Domain	ADAM_spacer1	THSD4 ADAMTSL4	5.44e-03	23	90	2	IPR010294
Domain	ADAM_spacer1	THSD4 ADAMTSL4	5.44e-03	23	90	2	PF05986
Domain	EGF_3	HEG1 CELSR3 SCARF2 LTBP4 PEAR1	5.58e-03	235	90	5	PS50026
Domain	EGF	HEG1 CELSR3 SCARF2 LTBP4 PEAR1	5.58e-03	235	90	5	SM00181
Domain	WH2	WASL WIPF1	5.92e-03	24	90	2	PS51082
Pathway	REACTOME_RHO_GTPASE_CYCLE	SRRM1 WASL WIPF1 RHOV PLEKHG3 ARHGEF5 SH3BP1 FGD1 MAP3K11 PRAG1 OPHN1 SOS1	1.92e-06	450	70	12	M27078
Pathway	REACTOME_CDC42_GTPASE_CYCLE	WASL WIPF1 PLEKHG3 ARHGEF5 FGD1 MAP3K11 OPHN1	1.14e-05	155	70	7	M41808
Pathway	REACTOME_RAC1_GTPASE_CYCLE	WASL WIPF1 PLEKHG3 ARHGEF5 SH3BP1 OPHN1 SOS1	3.45e-05	184	70	7	M41809
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	SRRM1 WASL WIPF1 RHOV PLEKHG3 ARHGEF5 SH3BP1 FGD1 MAP3K11 PRAG1 OPHN1 MEN1 SOS1	4.61e-05	720	70	13	M41838
Pathway	REACTOME_RHO_GTPASE_CYCLE	SRRM1 RHOV PLEKHG3 ARHGEF5 SH3BP1 FGD1 MAP3K11 PRAG1 OPHN1 SOS1	5.77e-05	439	70	10	MM15595
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	SRRM1 WIPF1 RHOV PLEKHG3 ARHGEF5 SH3BP1 FGD1 MAP3K11 PRAG1 OPHN1 MEN1 SOS1	7.50e-05	649	70	12	MM15690
Pathway	REACTOME_NOSTRIN_MEDIATED_ENOS_TRAFFICKING	WASL DNM2	2.41e-04	5	70	2	M27112
Pathway	KEGG_ENDOCYTOSIS	ACAP1 ITCH IQSEC1 VPS37D DNM2 MVB12B	2.74e-04	181	70	6	M1519
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE	NDST2 HS6ST3 B3GAT3	2.81e-04	26	70	3	M7330
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SETD1A NCOR1 HEG1 CELSR3 EPOP SYNJ1 SZT2 CDK13 MAP3K11 FBXL19 PRAG1 LTBP4 PLEKHH3 ZNF687 MVB12B HR KLHL17	6.39e-09	1105	94	17	35748872
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	SRRM1 WASL WIPF1 SYNJ1 SYNJ2 FAM83G DNM2	1.87e-08	108	94	7	19531213
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	ACAP1 WASL CELSR3 WIPF1 SYNJ2 SCARF2 SHANK3 DNM2 SOS1	2.86e-07	329	94	9	17474147
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	WASL IRS4 WIPF1 SYNJ1 DNM2 SOS1	3.84e-07	103	94	6	21706016
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	WASL WIPF1 SYNJ2 LTBP4 DNM2 SOS1	5.98e-07	111	94	6	22558309
Pubmed	Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.	WIPF1 SH3BP1 DNM2 SOS1	6.06e-07	25	94	4	12029088
Pubmed	Alternative splicing affecting the SH3A domain controls the binding properties of intersectin 1 in neurons.	WASL SYNJ1 SOS1	1.59e-06	9	94	3	18539136
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	VGF TPR NCOR1 SORBS2 ITCH SYNJ1 ICAM5 SH3BP1 IQSEC1 LMTK3 SHANK3 MAPK8IP2 DNM2	1.97e-06	963	94	13	28671696
Pubmed	Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.	SETD1A KIFC1 MEN1	3.11e-06	11	94	3	18082152
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SRRM1 SORBS2 IRS4 ITCH SYNJ1 SYNJ2 PLEKHG3 ARHGEF5 IQSEC1 FAM83G PROSER2 PRAG1	3.65e-06	861	94	12	36931259
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	TPR SRRM1 WASL PABPN1 PLEKHG3 ARHGEF5 SH3BP1 KPRP FGD1 OPHN1 DNM2 SOS1	6.84e-06	916	94	12	32203420
Pubmed	Nkx2-8 downregulation promotes angiogenesis and activates NF-κB in esophageal cancer.	NKX2-8 RELA	7.23e-06	2	94	2	23604637
Pubmed	MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice.	FGD1 MAP3K11	7.23e-06	2	94	2	21965325
Pubmed	Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome.	WASL WIPF1	7.23e-06	2	94	2	12437929
Pubmed	The Synaptojanins in the murine small and large intestine.	SYNJ1 SYNJ2	7.23e-06	2	94	2	27878645
Pubmed	Invadopodia proteins, cortactin, N-WASP and WIP differentially promote local invasiveness in ameloblastoma.	WASL WIPF1	7.23e-06	2	94	2	26752341
Pubmed	Cerebellar and posterior fossa malformations in patients with autism-associated chromosome 22q13 terminal deletion.	SHANK3 MAPK8IP2	7.23e-06	2	94	2	23225497
Pubmed	Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse.	CYS1 KIF12	7.23e-06	2	94	2	26295839
Pubmed	Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse.	CYS1 KIF12	7.23e-06	2	94	2	15728779
Pubmed	Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging.	KL SLC34A1	7.23e-06	2	94	2	20418498
Pubmed	Developmentally regulated alternative splicing in a novel synaptojanin.	SYNJ1 SYNJ2	7.23e-06	2	94	2	9442075
Pubmed	A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusion.	WASL WIPF1	7.23e-06	2	94	2	17419995
Pubmed	The mouse homologs of RELA and MLK3 are located within a 120-kb fragment on chromosome 19.	MAP3K11 RELA	7.23e-06	2	94	2	9195998
Pubmed	SIRT6 abrogation promotes adrenocortical carcinoma through activation of NF-κB signaling.	RELA SIRT6	7.23e-06	2	94	2	30989475
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TPR SRRM1 NCOR1 SORBS2 RBMXL2 CDK13 IQSEC1 PROSER2 ZNF687 DNM2 SOS1	7.98e-06	774	94	11	15302935
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	SORBS2 ITCH SYNJ2 ARHGEF5 PRAG1	8.77e-06	102	94	5	15778465
Pubmed	CIN85 interacting proteins in B cells-specific role for SHIP-1.	WASL WIPF1 SH3BP1 DNM2	1.43e-05	54	94	4	21725061
Pubmed	Upregulation of RPA2 promotes NF-κB activation in breast cancer by relieving the antagonistic function of menin on NF-κB-regulated transcription.	RELA MEN1	2.16e-05	3	94	2	28007956
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2B NUTM2A	2.16e-05	3	94	2	22456610
Pubmed	Waltzing with WASP.	WASL WIPF1	2.16e-05	3	94	2	10087612
Pubmed	SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.	RELA SIRT6	2.16e-05	3	94	2	19135889
Pubmed	WIP provides an essential link between Nck and N-WASP during Arp2/3-dependent actin polymerization.	WASL WIPF1	2.16e-05	3	94	2	23707428
Pubmed	Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages.	KL SLC34A1	2.16e-05	3	94	2	32026654
Pubmed	The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs.	WASL WIPF1	2.16e-05	3	94	2	12372256
Pubmed	Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain.	RELA MEN1	2.16e-05	3	94	2	14508515
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	2.16e-05	3	94	2	26542179
Pubmed	Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin.	GRID2IP ICAM5	2.16e-05	3	94	2	18509461
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	NCOR1 XIRP2 IQSEC1 LMTK3 SHANK3 MAPK8IP2	4.22e-05	233	94	6	37704626
Pubmed	The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.	RELA MEN1	4.32e-05	4	94	2	11526476
Pubmed	WIP regulates N-WASP-mediated actin polymerization and filopodium formation.	WASL WIPF1	4.32e-05	4	94	2	11331876
Pubmed	In vivo evidence for a limited role of proximal tubular Klotho in renal phosphate handling.	KL SLC34A1	4.32e-05	4	94	2	27292223
Pubmed	ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice.	ITCH SIRT6	4.32e-05	4	94	2	25777360
Pubmed	Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.	WASL WIPF1	4.32e-05	4	94	2	15684033
Pubmed	Grb2 dominantly associates with dynamin II in human hepatocellular carcinoma HepG2 cells.	DNM2 SOS1	4.32e-05	4	94	2	11746524
Pubmed	FBP17 Mediates a Common Molecular Step in the Formation of Podosomes and Phagocytic Cups in Macrophages.	WIPF1 DNM2	4.32e-05	4	94	2	19155218
Pubmed	The SAC domain-containing protein gene family in Arabidopsis.	SYNJ1 SYNJ2	4.32e-05	4	94	2	12805586
Pubmed	Critical Roles of Xirp Proteins in Cardiac Conduction and Their Rare Variants Identified in Sudden Unexplained Nocturnal Death Syndrome and Brugada Syndrome in Chinese Han Population.	KCNA5 XIRP2	4.32e-05	4	94	2	29306897
Pubmed	SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2.	WASL DNM2	4.32e-05	4	94	2	18388313
Pubmed	Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment.	ARID1B SHANK3	4.32e-05	4	94	2	33262327
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	SRRM1 WASL ITCH WIPF1 DNM2	6.37e-05	154	94	5	16055720
Pubmed	Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1.	MAP3K11 RELA	7.19e-05	5	94	2	16142231
Pubmed	A unique set of SH3-SH3 interactions controls IB1 homodimerization.	MAP3K11 MAPK8IP2	7.19e-05	5	94	2	16456539
Pubmed	WIP modulates dendritic spine actin cytoskeleton by transcriptional control of lipid metabolic enzymes.	WASL WIPF1	7.19e-05	5	94	2	24698977
Pubmed	Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.	WASL WIPF1	7.19e-05	5	94	2	22966049
Pubmed	Determination of kainate receptor subunit ratios in mouse brain using novel chimeric protein standards.	ICAM5 GRIK4	7.19e-05	5	94	2	26448475
Pubmed	In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules.	KL SLC34A1	1.08e-04	6	94	2	29993278
Pubmed	Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities.	ARID1B SHANK3	1.08e-04	6	94	2	35445787
Pubmed	Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1.	SORBS2 SYNJ1	1.08e-04	6	94	2	11292345
Pubmed	The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis.	SYNJ1 SH3BP1	1.08e-04	6	94	2	10764144
Pubmed	All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.	WASL SYNJ1	1.08e-04	6	94	2	11082044
Pubmed	Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion.	WASL WIPF1	1.08e-04	6	94	2	16582881
Pubmed	Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.	SYNJ1 DNM2	1.08e-04	6	94	2	23187129
Pubmed	The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.	SYNJ1 DNM2	1.50e-04	7	94	2	10542231
Pubmed	Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis.	WASL DNM2	1.50e-04	7	94	2	16418535
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SETD1A NCOR1 IRS4 XIRP2 ARHGEF5 LMTK3 SOS1	1.71e-04	430	94	7	35044719
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	TPR SRRM1 SETD1A ARID1B IRS4 ITCH RELA LTBP4 VPS37D MVB12B	1.98e-04	922	94	10	27609421
Pubmed	SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.	MAP3K11 SOS1	2.00e-04	8	94	2	9346925
Pubmed	The JIP group of mitogen-activated protein kinase scaffold proteins.	MAP3K11 MAPK8IP2	2.00e-04	8	94	2	10490659
Pubmed	The GTPase dynamin binds to and is activated by a subset of SH3 domains.	SH3BP1 SOS1	2.00e-04	8	94	2	8402898
Pubmed	Identification of novel interacting partners of Sirtuin6.	RELA SIRT6	2.00e-04	8	94	2	23240041
Pubmed	Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission.	SYNJ1 DNM2	2.00e-04	8	94	2	22099461
Pubmed	Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals.	NKX2-8 NKX2-4	2.57e-04	9	94	2	10818213
Pubmed	A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission.	VPS37D MVB12B	2.57e-04	9	94	2	32424346
Pubmed	Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.	SH3BP1 OPHN1	2.57e-04	9	94	2	22891260
Pubmed	Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding.	VPS37D MVB12B	2.57e-04	9	94	2	18005716
Pubmed	Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia.	NKX2-8 NKX2-4	2.57e-04	9	94	2	9344671
Pubmed	Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes.	ITCH MVB12B	3.21e-04	10	94	2	34999730
Pubmed	Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.	MAP3K11 MAPK8IP2	3.21e-04	10	94	2	10629060
Pubmed	Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936.	KL SHANK3	3.21e-04	10	94	2	19077115
Pubmed	A human MAP kinase interactome.	TPR WASL WIPF1 SYNJ2 MAP3K11 RELA SOS1	3.58e-04	486	94	7	20936779
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	SRRM1 KL SYNJ1 IQSEC1 LMTK3 SOS1	3.68e-04	347	94	6	17114649
Pubmed	Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.	NDST2 HS6ST3	3.91e-04	11	94	2	15944372
Pubmed	Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1.	SYNJ1 DNM2	3.91e-04	11	94	2	12456676
Pubmed	HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity.	NCOR1 RELA	3.91e-04	11	94	2	32467224
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	NCOR1 WASL ARID1B ITCH WIPF1 XIRP2 DNM2	4.09e-04	497	94	7	23414517
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	TPR SRRM1 NCOR1 CDK13 FAM83G MAP3K11 ZNF687	4.40e-04	503	94	7	16964243
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	TPR SRRM1 WASL IRS4 SYNJ1 PABPN1 CDK13	4.56e-04	506	94	7	30890647
Pubmed	A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton.	WASL DNM2	4.69e-04	12	94	2	12672817
Pubmed	NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.	ITCH PABPN1	4.69e-04	12	94	2	24107629
Pubmed	Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.	NDST2 HS6ST3	4.69e-04	12	94	2	12460940
Pubmed	Glutamatergic Dysfunction and Synaptic Ultrastructural Alterations in Schizophrenia and Autism Spectrum Disorder: Evidence from Human and Rodent Studies.	SHANK3 MAPK8IP2	5.53e-04	13	94	2	33374598
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TPR SETD1A NCOR1 ARID1B IRS4 SYNJ1 ICAM5	7.37e-04	549	94	7	38280479
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	THSD4 PRELP LTBP4 ADAMTSL4	8.08e-04	153	94	4	25037231
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	SETD1A MMP24 ARID1B KCNA5 CDK13 FBXL19 DNM2 KLHL17	8.27e-04	730	94	8	34857952
Pubmed	Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.	ARHGEF5 DNM2 SOS1	8.44e-04	68	94	3	25754235
Pubmed	Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice.	KL SLC34A1	8.46e-04	16	94	2	24470103
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SORBS2 SYNJ1 IQSEC1 PRAG1 SHANK3	1.02e-03	281	94	5	28706196
Pubmed	Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.	ARID1B SLC34A1	1.08e-03	18	94	2	24068962
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	SETD1A MEN1	1.08e-03	18	94	2	17500065
Pubmed	Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.	SYNJ1 DNM2	1.08e-03	18	94	2	27984743
Interaction	PACSIN1 interactions	WASL ITCH WIPF1 SYNJ1 SHANK3 DNM2 SOS1	9.62e-09	60	91	7	int:PACSIN1
Interaction	ITSN2 interactions	WASL WIPF1 SYNJ2 PABPN1 FBXL19 LMTK3 LTBP4 DNM2 SOS1	2.15e-08	147	91	9	int:ITSN2
Interaction	SH3RF1 interactions	ACAP1 WASL SORBS2 WIPF1 RHOV FGD1 MAP3K11 DNM2	3.08e-08	108	91	8	int:SH3RF1
Interaction	CRKL interactions	IRS4 WIPF1 ARHGEF5 PNRC1 PRAG1 LTBP4 SHANK3 DNM2 SOS1	8.76e-07	227	91	9	int:CRKL
Interaction	SH3KBP1 interactions	SRRM1 WASL WIPF1 SYNJ1 SYNJ2 SH3BP1 KPRP FAM83G DNM2 SOS1	1.58e-06	315	91	10	int:SH3KBP1
Interaction	BIN1 interactions	WASL IRS4 ITCH SYNJ1 RIN2 DNM2 SOS1	1.94e-06	129	91	7	int:BIN1
Interaction	NCK2 interactions	WASL SORBS2 WIPF1 RHOV TRIM41 KPRP FBXL19 PRDM6 SOS1	2.86e-06	262	91	9	int:NCK2
Interaction	GRB2 interactions	ACAP1 WASL IRS4 ITCH WIPF1 SYNJ1 SYNJ2 ARHGEF5 SH3BP1 KPRP PNRC1 PRAG1 SHANK3 DNM2 SOS1	3.03e-06	806	91	15	int:GRB2
Interaction	SORBS3 interactions	WASL SORBS2 SYNJ1 TRIM41 FBXL19 ZNF414 ADAMTSL4 SHANK3	3.70e-06	202	91	8	int:SORBS3
Interaction	TOP3B interactions	SETD1A NCOR1 HEG1 CELSR3 EPOP SYNJ1 SZT2 PABPN1 CDK13 TRIM41 MAP3K11 FBXL19 PRAG1 LTBP4 ADAMTSL4 PLEKHH3 ZNF687 MVB12B HR KLHL17	6.97e-06	1470	91	20	int:TOP3B
Interaction	TRIP10 interactions	WASL SH3BP1 SIRT6 SHANK3 DNM2 MEN1	1.00e-05	109	91	6	int:TRIP10
Interaction	NCK1 interactions	WASL WIPF1 SYNJ2 SCARF2 RHOV SHANK3 DNM2 SOS1	1.47e-05	244	91	8	int:NCK1
Interaction	PACSIN2 interactions	TPR WASL WIPF1 SYNJ1 RHOV SH3BP1 DNM2	2.07e-05	185	91	7	int:PACSIN2
Interaction	ITSN1 interactions	WASL ITCH SYNJ1 SYNJ2 SHANK3 MAPK8IP2 DNM2 SOS1	2.26e-05	259	91	8	int:ITSN1
Interaction	PACSIN3 interactions	WASL WIPF1 SYNJ1 DNM2 MEN1 SOS1	2.85e-05	131	91	6	int:PACSIN3
Interaction	ITIH6 interactions	KPRP ITIH6 ZNF414	3.13e-05	14	91	3	int:ITIH6
Interaction	SH3GL2 interactions	ITCH SYNJ1 SYNJ2 SHANK3 DNM2	4.90e-05	88	91	5	int:SH3GL2
Interaction	CBFA2T2 interactions	NCOR1 FBXL19 PRDM6 MEN1	5.03e-05	45	91	4	int:CBFA2T2
Interaction	SNX9 interactions	WASL ITCH SYNJ1 SIRT6 DNM2 SOS1	6.09e-05	150	91	6	int:SNX9
Interaction	ABI1 interactions	SRRM1 WASL SORBS2 FBXL19 SHANK3 DNM2 SOS1	6.81e-05	223	91	7	int:ABI1
Interaction	CNFN interactions	KPRP ZNF414 HR	6.92e-05	18	91	3	int:CNFN
Interaction	NUFIP2 interactions	THSD4 KPRP RELA SIRT6 LTBP4 ADAMTSL4 DNM2 PEAR1 MEN1	1.12e-04	417	91	9	int:NUFIP2
Interaction	SORBS2 interactions	WASL SORBS2 SYNJ1 SHANK3 OPHN1	1.48e-04	111	91	5	int:SORBS2
Interaction	WASL interactions	WASL SORBS2 ITCH WIPF1 RHOV	1.89e-04	117	91	5	int:WASL
Interaction	EHMT1 interactions	XAGE3 RELA SIRT6 PRDM6 TLX2 MEN1	2.10e-04	188	91	6	int:EHMT1
Cytoband	20p11.22	NKX2-4 RIN2	1.20e-04	8	96	2	20p11.22
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ACAP1 PLEKHG3 FGD1 PLEKHH3 DNM2 SOS1	8.05e-05	206	63	6	682
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG3 ARHGEF5 FGD1 SOS1	8.20e-05	66	63	4	722
GeneFamily	ADAMTS like	THSD4 ADAMTSL4	2.48e-04	7	63	2	947
GeneFamily	Sulfotransferases, membrane bound	NDST2 GAL3ST3 HS6ST3	2.88e-04	37	63	3	763
GeneFamily	ESCRT-I	VPS37D MVB12B	4.23e-04	9	63	2	1116
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	ACAP1 OPHN1	1.57e-03	17	63	2	1291
GeneFamily	NKL subclass homeoboxes and pseudogenes	NKX2-8 NKX2-4 TLX2	1.65e-03	67	63	3	519
GeneFamily	Phosphoinositide phosphatases	SYNJ1 SYNJ2	5.54e-03	32	63	2	1079
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1A PRDM6	6.24e-03	34	63	2	487
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SORBS2 KCNA5 LRRC10B DACT3 WFDC1 PRDM6 PLEKHH3	8.38e-09	194	94	8	80be44e9ddd9f6ddd9dff7cba0eb457431204c2d
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SORBS2 KCNA5 LRRC10B DACT3 WFDC1 PRDM6	1.67e-07	191	94	7	8597a8af294f24496c317d995f07eb5dcc25c13c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNA5 EPOP PRELP DACT3 WFDC1 HR	1.82e-06	173	94	6	ecbf7167d4bec685e3460d826318544946f5f5c2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNA5 EPOP PRELP DACT3 WFDC1 HR	1.82e-06	173	94	6	b8dc978c52de64afba21ff6cb32e79f07167448e
ToppCell	droplet-Kidney-nan-18m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SORBS2 KCNA5 DACT3 WFDC1 PRDM6	2.29e-06	180	94	6	b6f44fdedc33b7d93b0074e8e9c8cc32009d4c4d
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2-VSMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SORBS2 KCNA5 NKX2-4 PRELP DACT3 WFDC1	2.77e-06	186	94	6	c7885fd6dc7dc8fffc96f0112c51a365cf8a8f80
ToppCell	Substantia_nigra-Neuronal-Inhibitory\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MMP24 CELSR3 SYNJ1 RHOV FBXL19 MAPK8IP2	2.77e-06	186	94	6	9d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SORBS2 KCNA5 DACT3 WFDC1 PRDM6	2.95e-06	188	94	6	d1a4cd4db95d8d32b79156290f7867f32824cc87
ToppCell	droplet-Kidney-nan-3m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 KCNA5 LRRC10B DACT3 WFDC1 PLEKHH3	3.04e-06	189	94	6	a959c9d6a0866582688a4204d625c1e5a123e93d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PRELP DACT3 WFDC1 LTBP4 PRDM6	3.04e-06	189	94	6	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PRELP DACT3 WFDC1 LTBP4 PRDM6	3.33e-06	192	94	6	992d08092edbc68c47b945deb8708379738c239a
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SORBS2 KCNA5 LRRC10B DACT3 WFDC1	3.33e-06	192	94	6	3617d2bc7e33d981f3ec349e9962d8d4bd822fbd
ToppCell	Thalamus-Neuronal\|Thalamus / BrainAtlas - Mouse McCarroll V32	MMP24 CELSR3 RHOV VPS37D B3GAT3 MAPK8IP2	3.43e-06	193	94	6	712a4acd1167e43543950bc819ff11984e6f718d
ToppCell	facs-Bladder-nan-3m-Epithelial-bladder_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 HEG1 SCARF2 PRELP WFDC1 PRDM6	3.64e-06	195	94	6	223f5f07dc28fa13a09bb589884c58043c7928c7
ToppCell	droplet-Bladder-nan-3m-Epithelial-bladder_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SCARF2 PRELP WFDC1 LTBP4 PRDM6	3.75e-06	196	94	6	f47e551ba484687ba6ce8c29a085106131364042
ToppCell	343B-Fibroblasts-Fibroblast-K_(Pericytes)\|343B / Donor, Lineage, Cell class and subclass (all cells)	SORBS2 KCNA5 PRELP DACT3 WFDC1 PRDM6	3.86e-06	197	94	6	78d45d11820ec379942c4c3defd619d5f8cc8e1f
ToppCell	343B-Fibroblasts-Fibroblast-K_(Pericytes)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	SORBS2 KCNA5 PRELP DACT3 WFDC1 PRDM6	3.86e-06	197	94	6	31bc9fd679d78550541d4158568e8dd09ff29e8e
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SORBS2 KCNA5 PRELP DACT3 WFDC1 PRDM6	3.97e-06	198	94	6	c7075dce915ab8387309fcb12c5f6a17d4100cda
ToppCell	facs-Trachea-nan-3m-Mesenchymal-chondrocyte\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SCARF2 PRELP RIN2 IQSEC1 PROSER2	3.97e-06	198	94	6	71e847e8c24744d6df4a960348ad2ecf310373b4
ToppCell	proximal-mesenchymal-Airway_Smooth_Muscle-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	THSD4 SORBS2 KCNA5 PRELP DACT3 WFDC1	4.21e-06	200	94	6	6fa339666c4032b29ac521e88f0e917a57013cde
ToppCell	proximal-3-mesenchymal-Airway_Smooth_Muscle\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	THSD4 SORBS2 KCNA5 PRELP DACT3 WFDC1	4.21e-06	200	94	6	e9a008bfe336002218c63d1c2231986e1b237621
ToppCell	proximal-mesenchymal-Airway_Smooth_Muscle\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	THSD4 SORBS2 KCNA5 PRELP DACT3 WFDC1	4.21e-06	200	94	6	5eeb8eb3fe74f5a8055c52ec77e38237bb63ed90
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	PLEKHG3 DACT3 WFDC1 PRDM6 PEAR1	2.27e-05	160	94	5	fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PRELP WFDC1 ADAMTSL4 PRDM6 PEAR1	2.87e-05	168	94	5	26aa96b2b547d11941cb803995ea3d302ee0518c
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEG1 SZT2 IQSEC1 RELA FBXL19	3.04e-05	170	94	5	55fe16d98ea284d05fb899888e4569c685644c7b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 KCNA5 ICAM5 GAPDHS PEAR1	3.12e-05	171	94	5	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 KCNA5 ICAM5 GAPDHS PEAR1	3.12e-05	171	94	5	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RHOV NDST2 LMTK3 KIFC1 HR	3.39e-05	174	94	5	2a96a4fd7d9ef05213b26103c689cf3a26968713
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-5\|TCGA-Lung / Sample_Type by Project: Shred V9	RHOV PLEKHG3 SH3BP1 LYPD3 HR	3.68e-05	177	94	5	a0c7d08469c513cecf87777c19876884f1511570
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRELP ICAM5 ARHGEF5 LTBP4 HR	3.89e-05	179	94	5	b70509288aaf4457afd350f6c45784521337ce0d
ToppCell	Control-Stromal-SMC\|Control / Disease state, Lineage and Cell class	SORBS2 KCNA5 PRELP WFDC1 PRDM6	3.89e-05	179	94	5	1378051bc62009eec2dbecf3d5d89baedbeb84eb
ToppCell	droplet-Limb_Muscle-Pre-Sort\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 LRRC10B LYPD3 WFDC1 LTBP4	3.99e-05	180	94	5	af2bafcd1b2082629de3ea336711add01565c4c4
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 LRRC10B LYPD3 WFDC1 LTBP4	3.99e-05	180	94	5	f29a995cf6e1a1836ed68b73258d9370bf3d4434
ToppCell	wk_15-18-Mesenchymal-Chondrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	THSD4 SORBS2 PRELP GAL3ST3 ITIH6	4.10e-05	181	94	5	8950844b3e65c7028d80da5787ae2ce509c3d52d
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	VGF CELSR3 HS6ST3 MAPK8IP2 TLX2	4.32e-05	183	94	5	9dfb398b9995d562864fe688861a831ada0814cd
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 DACT3 WFDC1 LTBP4 PRDM6	4.32e-05	183	94	5	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNA5 PRELP DACT3 WFDC1 PRDM6	4.43e-05	184	94	5	603faafb7b289a3c0242c84fc800c050c8a092ea
ToppCell	Control-Stromal-SMC\|World / Disease state, Lineage and Cell class	SORBS2 KCNA5 PRELP WFDC1 PRDM6	4.43e-05	184	94	5	88b1a4c9a96a99fc3a39f7a2c3d0838739606f3e
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response-SM_activated_stress_response_L.2.3.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNA5 PRELP DACT3 WFDC1 PRDM6	4.43e-05	184	94	5	c350504bfe0ec31cd2fc2199de9b5fff151a8c5e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CLEC2L XIRP2 MISP3 PROSER2 PEAR1	4.54e-05	185	94	5	9bff336510c80cd762b4e41b4570475033e709ca
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CLEC2L XIRP2 MISP3 PROSER2 PEAR1	4.54e-05	185	94	5	452d49c7835a4d55e41caefa44dac5cab30e7ced
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic-Megakaryocyte\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CLEC2L XIRP2 MISP3 PROSER2 PEAR1	4.54e-05	185	94	5	53f5136ee1bd101dd5ac8a2c9e63b0c3b987657e
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	VGF CELSR3 HS6ST3 MAPK8IP2 TLX2	4.54e-05	185	94	5	512f489daeb3b72d4578dc6f4d0ebb5f38d5bbab
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 DACT3 WFDC1 LTBP4 PRDM6	4.54e-05	185	94	5	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PRELP WFDC1 LTBP4 PRDM6	4.54e-05	185	94	5	e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CLEC2L XIRP2 MISP3 PROSER2 PEAR1	4.54e-05	185	94	5	67ac5c2bacdbdcb40ee65c44da55b3f597b410ee
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PRELP WFDC1 LTBP4 PRDM6	4.66e-05	186	94	5	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDK13 PRELP LTBP4 SHANK3 PEAR1	4.66e-05	186	94	5	2cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDK13 PRELP LTBP4 SHANK3 PEAR1	4.66e-05	186	94	5	90d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MMP24 CELSR3 SYNJ1 RHOV MAPK8IP2	4.66e-05	186	94	5	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 KCNA5 DACT3 WFDC1 PRDM6	4.66e-05	186	94	5	a95744b8649096bd7cfc3591a02841fa411085b3
ToppCell	droplet-Kidney-nan-3m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEG1 KCNA5 WFDC1 LTBP4 HR	4.91e-05	188	94	5	ec0e241de2c8310b4417b9d4e2420d7a1662f1c0
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	SCARF2 DACT3 PRAG1 SHANK3 PEAR1	4.91e-05	188	94	5	c90669b51e1902fe7726555290c91c92a911df83
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-chondrocyte\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SORBS2 SCARF2 PRELP ITIH6 HR	4.91e-05	188	94	5	c9270517e6940e9793586f67f02431210552f278
ToppCell	Substantia_nigra-Endothelial\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SCARF2 PRELP ARHGEF5 WFDC1 PEAR1	5.03e-05	189	94	5	bef8234bd9c4d6e3cdef0791d8066b39ba56ebba
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF2 PRELP DACT3 LTBP4 PRDM6	5.03e-05	189	94	5	32e6d6285b258831b965281224ff2aaeecdcb5f5
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SORBS2 KCNA5 PRELP WFDC1 PRAG1	5.03e-05	189	94	5	d0c7549be4f77520c23dddf4f94d0fcad0081e37
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF2 PRELP DACT3 LTBP4 PRDM6	5.03e-05	189	94	5	385ef7bbd76c8047aeecf6542377d4213b5da5db
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PRELP DACT3 ADAMTSL4 PRDM6	5.03e-05	189	94	5	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SORBS2 IRS4 LRRC10B WFDC1	5.29e-05	191	94	5	8e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 PRELP DACT3 WFDC1 PRDM6	5.29e-05	191	94	5	08042952431ca1a6fd7dfc13f36eb28643979598
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRELP DACT3 WFDC1 LTBP4 PRDM6	5.29e-05	191	94	5	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SORBS2 IRS4 LRRC10B WFDC1	5.29e-05	191	94	5	60bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEG1 PRELP FAM83G LTBP4 HR	5.29e-05	191	94	5	8691eba35793e4e90f93d50c2145847ee51289f7
ToppCell	droplet-Lung-30m-Mesenchymal\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYS1 SCARF2 PRELP LTBP4 PRDM6	5.42e-05	192	94	5	5d5bec238b196f0b3e727fd94f078d6ae524cb01
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYS1 SCARF2 PRELP LTBP4 PRDM6	5.42e-05	192	94	5	ff4b728a55c2550c806c47e9ae3d057c35df8464
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-alveolar_fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYS1 SCARF2 PRELP LTBP4 PRDM6	5.42e-05	192	94	5	2d3790bd80a7f214b37094121a2a86ff16362569
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEG1 CDK13 RIN2 IQSEC1 DNM2	5.42e-05	192	94	5	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SORBS2 KCNA5 NUTM2B LRRC10B DACT3	5.56e-05	193	94	5	7631bf3362b4fa061ffeab4879ab12c4708dc4c0
ToppCell	droplet-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SCARF2 PRELP WFDC1 LTBP4	5.56e-05	193	94	5	2d891c00b8f0aace17d4c300b63e2341dcffa199
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SORBS2 KCNA5 NUTM2B LRRC10B DACT3	5.56e-05	193	94	5	8d15c63f2ae48d0a00d7ef5fdafa917ab8ad0571
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 HEG1 SYNJ2 LTBP4 SHANK3	5.56e-05	193	94	5	cc355b2ed6510619cad969ae074126d7c8db784d
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RHOV SH3BP1 GAL3ST3 LMTK3 MAPK8IP2	5.56e-05	193	94	5	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SORBS2 RHOV ARHGEF5 LYPD3	5.56e-05	193	94	5	22ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SORBS2 KCNA5 LRRC10B DACT3 WFDC1	5.69e-05	194	94	5	5099e6ad7c19e5f8b73449d904aaefd97f1b1959
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SORBS2 KCNA5 LRRC10B DACT3 WFDC1	5.69e-05	194	94	5	71734ef7b34ab33b349595368176fa0e1175d4d0
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF2 PRELP DACT3 LTBP4 PRDM6	5.69e-05	194	94	5	d47e3c7b22444aef0c7a37bc8cd8853b590a56dd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 PRELP GRIK4 HS6ST3 LTBP4	5.83e-05	195	94	5	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	facs-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SCARF2 PRELP WFDC1 PRDM6	5.83e-05	195	94	5	18b01ab63ee1deae3cf29669d66fff9ca4efc5c4
ToppCell	distal-Epithelial-Differentiating_Basal-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NKX2-8 RHOV ICAM5 LYPD3 LMTK3	5.83e-05	195	94	5	3fe6e49a9161fc9e5160251e6932cb5378175a54
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYS1 PRELP FGD1 LTBP4 PRDM6	5.83e-05	195	94	5	d32716a12014522492becbde1088dc1106308490
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNA5 PRELP DACT3 WFDC1 PEAR1	5.83e-05	195	94	5	9ab3c5b0fb12d406408122a535b717bfe184bbcf
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNA5 PRELP DACT3 WFDC1 PEAR1	5.83e-05	195	94	5	21263d138c81f6a0219f2cd93126cfafd35732b2
ToppCell	droplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYS1 PRELP FGD1 LTBP4 PRDM6	5.83e-05	195	94	5	b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCell	tumor_Lung-Fibroblasts-Smooth_muscle_cells\|tumor_Lung / Location, Cell class and cell subclass	KCNA5 PRELP DACT3 WFDC1 PRDM6	5.83e-05	195	94	5	ea9ff25020c2fcd1bab80e1829af0f4e4777de8b
ToppCell	droplet-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SCARF2 PRELP WFDC1 PRDM6	5.83e-05	195	94	5	095b8e0be385b6390420589124a95fa4ba3682ab
ToppCell	356C-Fibroblasts-Fibroblast-K_(Pericytes)\|356C / Donor, Lineage, Cell class and subclass (all cells)	SORBS2 KCNA5 PRELP WFDC1 PRDM6	5.98e-05	196	94	5	a5cc4f76e1a3825aaccba9a686d7da6f7e4300ff
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SORBS2 KCNA5 LRRC10B DACT3 WFDC1	5.98e-05	196	94	5	ce6f7ddb8104471dc90347f427486379914d63b4
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 HEG1 SYNJ2 LTBP4 SHANK3	5.98e-05	196	94	5	a20a56d8997d6db2a10046c8801c619a379de83c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	THSD4 HEG1 SORBS2 SHANK3 PEAR1	5.98e-05	196	94	5	889c9fed857f64664ca1f47fcec9fecb15ed103c
ToppCell	356C-Fibroblasts-Fibroblast-K_(Pericytes)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	SORBS2 KCNA5 PRELP WFDC1 PRDM6	5.98e-05	196	94	5	476812fc1422aca8010d771eff11fa6081f15a2d
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SORBS2 KCNA5 LRRC10B DACT3 WFDC1	5.98e-05	196	94	5	6d7179decea512dd49bb2d5f6a4f5989349d52a9
ToppCell	distal-3-Epithelial-Differentiating_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NKX2-8 RHOV ICAM5 LYPD3 LMTK3	5.98e-05	196	94	5	77635a0f86910c4019d3370e9c8ba41de176bcf3
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	THSD4 HEG1 SORBS2 SHANK3 PEAR1	6.12e-05	197	94	5	e567f91fa398fd306d025dcfe89bd50a60216537
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THSD4 SORBS2 PRELP IQSEC1 PROSER2	6.12e-05	197	94	5	4b6c0e028b9669c102df8e9dc63e284f8d5fd9ee
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 SCARF2 PRELP WFDC1 PRDM6	6.12e-05	197	94	5	86145bc1e585b4ae136e755cafd6579da2abfa65
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THSD4 SORBS2 PRELP IQSEC1 PROSER2	6.12e-05	197	94	5	ece0c17eb68f394b20e588c0b0626d3987a4dbbb
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SORBS2 KCNA5 LRRC10B DACT3 WFDC1	6.12e-05	197	94	5	d16bb765afdc02406ffd7ce6a75bae72b66db66c
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SORBS2 KCNA5 LRRC10B DACT3 WFDC1	6.12e-05	197	94	5	aafe279b14cdcb786bc45524bc3c26261128ee48
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SORBS2 KCNA5 LRRC10B DACT3 WFDC1	6.12e-05	197	94	5	fb14da600f563273059a4683a5079af81aca0886
Drug	Esculin Hydrate [531-75-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SETD1A NCOR1 HEG1 CELSR3 CDK13 RIN2 SIRT6 MVB12B	1.42e-06	196	93	8	5411_DN
Disease	Hypercalcemia, Idiopathic, of Infancy	KL SLC34A1	2.88e-05	3	92	2	C0268080
Disease	Endometrial Stromal Sarcoma	NUTM2B NUTM2A	9.56e-05	5	92	2	C0206630
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	1.43e-04	6	92	2	C0334488
Disease	early-onset Parkinson's disease (implicated_via_orthology)	SYNJ1 SYNJ2	1.43e-04	6	92	2	DOID:0060894 (implicated_via_orthology)
Disease	end stage renal disease (biomarker_via_orthology)	KL SLC34A1 RELA	4.31e-04	47	92	3	DOID:783 (biomarker_via_orthology)
Disease	Hypercalcemia	KL SLC34A1	7.33e-04	13	92	2	C0020437
Disease	Milk-Alkali Syndrome	KL SLC34A1	7.33e-04	13	92	2	C0026141
Disease	Down syndrome (implicated_via_orthology)	SYNJ1 SYNJ2	9.83e-04	15	92	2	DOID:14250 (implicated_via_orthology)
Disease	phosphorus measurement	AHI1-DT SLC34A1	1.12e-03	16	92	2	EFO_0004861
Disease	response to radiation, Urinary retention	NKX2-8 DNM2	1.27e-03	17	92	2	GO_0009314, HP_0000016
Disease	prostate cancer (is_marker_for)	CDK13 FGD1 WFDC1 SOS1	1.46e-03	156	92	4	DOID:10283 (is_marker_for)
Disease	Malignant neoplasm of breast	NCOR1 ACAP1 CTU2 ARID1B KCNA5 SYNJ2 SCARF2 ICAM5 WFDC1 RELA	1.90e-03	1074	92	10	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRPVKPREPPARSPS	ADM2	31	Q7Z4H4
PPEPAPRRPARLRPT	CYS1	86	Q717R9
PPPSPPARREPRAVP	FAM246A	156	A0A494C0Y3
PPPSPPARREPRAVP	FAM246B	156	A0A494C0N9
AELRRPPPAPAQPPE	B3GAT3	56	O94766
SLPLPPRPPRHPEAL	ADAMTSL4	81	Q6UY14
IHEPLPPPPPQRRDT	ARHGEF5	721	Q12774
VPTPPAIPPQPRPRS	SH3BP1	681	Q9Y3L3
PVPPKPSIRPRPGSL	ACAP1	541	Q15027
PPQPPPIRREITFPP	ARID1B	1666	Q8NFD5
LPPPRPREREQSPPL	AHI1-DT	176	P0C7V0
RPRILPPDQRPPEPP	CDK13	1251	Q14004
PPRPPQLERHVVRPP	FBXL19	391	Q6PCT2
TIIRPPVRPPDPPCR	OPHN1	736	O60890
RGPRRESKPEEPPPP	MEN1	486	O00255
ERQPRPPRPPLGDRP	MMP24	356	Q9Y5R2
PPPPPSPRRVAVPVL	NKX2-4	266	Q9H2Z4
PPLPVRPPKTSPGLR	KIF12	586	Q96FN5
PREEPELRPRPPRPL	IQSEC1	431	Q6DN90
EPEPPREPPRRPAFL	MAPK8IP2	306	Q13387
EGVPRPRAPPEPPDP	LMTK3	816	Q96Q04
RVRPVLPGEPTPPPG	KIFC1	316	Q9BW19
PLSPVRPRLPPPGAL	HR	831	O43593
PLPRIPDPRALPPTL	PNRC1	41	Q12796
PLAPPDPSPRAPRIP	ICAM5	621	Q9UMF0
LPPVRHPPSPPLRRQ	PEAR1	1021	Q5VY43
DEPTPRPPPRRPARA	LRRC10B	241	A6NIK2
LERRPEREPPPTPPR	HEG1	56	Q9ULI3
EREPPPTPPRERRGP	HEG1	61	Q9ULI3
PRREPEPRAPQPDPC	NKX2-8	26	O15522
PAPPQIPSRPVRIPP	DNM2	826	P50570
ERRPQLPPPPRGPPE	HS6ST3	66	Q8IZP7
FSPRIPPLVRLPPPE	LYPD3	231	O95274
CVRRSRDPPPPQPPP	MVB12B	6	Q9H7P6
PPPPERAEPPPDSLR	PRDM6	56	Q9NQX0
ARPEPRSPPLPPRVF	SLC34A1	601	Q06495
PSRPPPPTPRRPASV	ITCH	256	Q96J02
PEPEPEEEPPRPRAP	PABPN1	66	Q86U42
RARPEPVLDNPPPRP	GAL3ST3	406	Q96A11
PVLDNPPPRPIRVLP	GAL3ST3	411	Q96A11
PPRRPDEPPPRRASL	GRID2IP	251	A4D2P6
RPLPPLPEELPRPRR	KCNA5	76	P22460
LPEELPRPRRPPPED	KCNA5	81	P22460
PPQPPAPEAERTRPR	KLHL17	31	Q6TDP4
EPRPPRPRRGPAPTL	DACT3	451	Q96B18
PAPPPRTAQPRRPAP	EPOP	291	A6NHQ4
LPPIRPPRSPEVPRE	FAM166B	61	A8MTA8
PTHRLEPRPEPRPDP	LTBP4	506	Q8N2S1
EPRPEPRPDPRPGPE	LTBP4	511	Q8N2S1
LPPRPDRPRPPLPES	ITIH6	886	Q6UXX5
VPEPSGPLRPPRPAE	DENND4B	31	O75064
PPRRPRPPPPSLSLL	KL	6	Q9UEF7
PPAPRPRLRPEPCIS	KPRP	401	Q5T749
RPTPRPVPLPRPGQC	KPRP	441	Q5T749
PSPPAPRPERPESLL	C1orf127	351	Q8N9H9
LPPPRRTRDLDPQPP	CELSR3	3156	Q9NYQ7
AAVPPPRPPIPEERR	GRIK4	866	Q16099
LLRQPCPVTRAPPPP	GAPDHS	16	O14556
PAPEEPPPAPRPSRE	CTU2	11	Q2VPK5
PRPSPLPSPQPAPRR	MAP3K11	786	Q16584
AAPEPPPRSRRVPRP	IRS4	1211	O14654
QDSRPRPEPCPPPEP	FAM83G	466	A6ND36
PATPRLEPRGPPAPE	NUTM2A	431	Q8IVF1
PATPRLEPRGPPAPE	NUTM2B	431	A6NNL0
PATPRLEPRGPPAPE	NUTM2E	431	B1AL46
RFRKPPRLPPEPEAP	SZT2	3211	Q5T011
DPVTPLPPPPAPRRC	TRIM41	166	Q8WV44
LPRLDRLLPPPAPPR	PLEKHH3	556	Q7Z736
RLLPPPAPPREDPPR	PLEKHH3	561	Q7Z736
RVPERAPLPPPAPSQ	VGF	216	O15240
PRPVAPPTRPAPPQR	SYNJ1	1111	O43426
PQAPPLLPRRPPPRV	SYNJ2	1221	O15056
RFNSLPRPDPEPVPP	PLEKHG3	756	A1L390
PPPLPSTPDPPRREL	PROSER2	161	Q86WR7
GVRLPTTRPTRPPPP	NCOR1	1021	O75376
PPPPSRPLPADPRVA	FGD1	181	P98174
PRPRPRPTPSFPQPD	PRELP	36	P51888
EVPVPPPVPPRRRPE	SOS1	1146	Q07889
PPVPPRRRPESAPAE	SOS1	1151	Q07889
VLERALPPLPRPPTP	SIRT6	281	Q8N6T7
SGPPRREPLPPRRDP	RBMXL2	191	O75526
RPDERPSSPIPLLPP	SETD1A	1146	O15047
PHVPPPVPPLRPRDR	SORBS2	171	O94875
EPPSRARPPPPLAAR	CLEC2L	6	P0C7M8
QSPELPSPPRRLPVP	XIRP2	296	A4UGR9
TRSARPPVLPPPPRP	nan	56	P0C880
PRADRCPPPPRTLPP	WFDC1	61	Q9HC57
TERTRSPPPRPPPPA	RIN2	301	Q8WYP3
PALDREPPAPERPPE	ZNF414	211	Q96IQ9
PPPLRAPTPPPRRRS	RHOV	11	Q96L33
APTPPPRRRSAPPEL	RHOV	16	Q96L33
RPAVPEPRARSPPQP	MISP3	81	Q96FF7
PRPPPAATPPERPKR	SHANK3	906	Q9BYB0
PQSPRRPPHPLPPRL	TPR	2071	P12270
PSPAPPPRRRRTPTP	SRRM1	561	Q8IYB3
RTPTPPPRRRTPSPP	SRRM1	571	Q8IYB3
SPSPERRKPPPPDPA	SCARF2	651	Q96GP6
PPRPPRPPETARTEP	NDST2	71	P52849
PPEPQRNRMPPPRPD	WIPF1	161	O43516
PRSLPPLDSRPVPPL	VPS37D	211	Q86XT2
PPPRLPPRPENCRLE	PRAG1	56	Q86YV5
VPSSPEPPRPAKRPR	ZNF687	931	Q8N1G0
PRPRRSVPPPELIGP	XAGE3	11	Q8WTP9
ELRRQAPPPPPPSRG	WASL	271	O00401
RPDNLVPPAPQPPRR	THSD4	601	Q6ZMP0
PTDPRPPPRRIAVPS	RELA	321	Q04206
PLVPQRPRPPGPDLD	TTLL10	616	Q6ZVT0
QDALPRPLRPPLPPD	TLX2	236	O43763