Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-dependent protein kinase activity

PRKDC ATM

1.02e-0431172GO:0004677
GeneOntologyMolecularFunctionhistone H2AXS139 kinase activity

PRKDC ATM

1.02e-0431172GO:0035979
GeneOntologyMolecularFunctionhistone H2AX kinase activity

PRKDC ATM

3.37e-0451172GO:0141003
GeneOntologyMolecularFunctionG-protein beta/gamma-subunit complex binding

GNA12 PLCB2 GNAL

4.10e-04251173GO:0031683
GeneOntologyMolecularFunctionlysine-acetylated histone binding

BRD3 BRD2 BRD4

7.09e-04301173GO:0070577
GeneOntologyMolecularFunctionacetylation-dependent protein binding

BRD3 BRD2 BRD4

7.82e-04311173GO:0140033
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RGPD8 ITSN1 TBC1D7 ARFGEF1 GIT2 CAVIN4 RASGRP3 ITSN2 RGPD5 RGL4

8.04e-0450711710GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RGPD8 ITSN1 TBC1D7 ARFGEF1 GIT2 CAVIN4 RASGRP3 ITSN2 RGPD5 RGL4

8.04e-0450711710GO:0030695
GeneOntologyBiologicalProcesscell cycle process

CUL4B CUL1 PDS5B OFD1 RTEL1 POLE SPTBN1 KIF4A CIT NCAPG2 TLK1 NCAPG CCDC42 WASHC5 BRD4 SEPTIN14 DYNC1LI1 PDS5A PRKDC ATM TBX20 PMF1

1.53e-05144111622GO:0022402
GeneOntologyBiologicalProcessclathrin-dependent synaptic vesicle endocytosis

ITSN1 ITSN2

3.14e-0521162GO:0150007
GeneOntologyBiologicalProcesspositive regulation of T-helper 17 cell differentiation

MALT1 BRD2 BRD4

6.03e-05141163GO:2000321
GeneOntologyBiologicalProcesschromosome segregation

OFD1 KIF4A CIT NCAPG2 TLK1 NCAPG WASHC5 BRD4 DYNC1LI1 ATM PMF1

6.37e-0546511611GO:0007059
DomainARM-type_fold

CEP104 PDS5B RELCH NBEAL1 MROH2A ARFGEF1 NCAPG2 ITPR2 NCAPG IPO9 INF2 PDS5A PRKDC ATM KPNA2

2.95e-0933911615IPR016024
DomainHEAT_REPEAT

CEP104 PDS5B RELCH MROH2A NCAPG2 NCAPG PDS5A PRKDC

1.19e-08701168PS50077
DomainBET

BRD3 BRD2 BRD4

9.30e-0741163PF17035
DomainNET_dom

BRD3 BRD2 BRD4

9.30e-0741163IPR027353
DomainNET

BRD3 BRD2 BRD4

9.30e-0741163PS51525
DomainARM-like

CEP104 PDS5B RELCH MROH2A ARFGEF1 NCAPG2 NCAPG IPO9 PDS5A PRKDC KPNA2

9.67e-0727011611IPR011989
Domain-

CEP104 PDS5B RELCH ARFGEF1 NCAPG2 NCAPG IPO9 PDS5A PRKDC KPNA2

1.25e-06222116101.25.10.10
DomainGrip

RGPD8 GCC2 RGPD5

3.71e-05111163SM00755
DomainGRIP

RGPD8 GCC2 RGPD5

3.71e-05111163PF01465
DomainPH_13

ITSN1 ITSN2

3.82e-0521162PF16652
DomainGRIP_dom

RGPD8 GCC2 RGPD5

4.93e-05121163IPR000237
DomainGRIP

RGPD8 GCC2 RGPD5

4.93e-05121163PS50913
DomainHEAT

CEP104 NCAPG2 NCAPG PRKDC

2.23e-04481164PF02985
DomainPH_dom-like

RGPD8 NBEAL1 ITSN1 SPTBN1 CIT ITK AFAP1L1 ITSN2 PLCB2 RGPD5

3.25e-0442611610IPR011993
DomainTPR-contain_dom

RGPD8 SRP72 TTC3 IFIT1B PRKDC RGPD5

3.49e-041501166IPR013026
DomainFATC

PRKDC ATM

3.78e-0451162PF02260
DomainHEAT

CEP104 NCAPG2 NCAPG PRKDC

4.63e-04581164IPR000357
DomainBromodomain_CS

BRD3 BRD2 BRD4

5.47e-04261163IPR018359
DomainFAT

PRKDC ATM

5.64e-0461162PS51189
DomainFATC

PRKDC ATM

5.64e-0461162PS51190
DomainFAT

PRKDC ATM

5.64e-0461162PF02259
DomainPIK-rel_kinase_FAT

PRKDC ATM

5.64e-0461162IPR003151
DomainFATC_dom

PRKDC ATM

5.64e-0461162IPR003152
DomainPIK_FAT

PRKDC ATM

5.64e-0461162IPR014009
DomainFATC

PRKDC ATM

5.64e-0461162SM01343
DomainTPR_REGION

RGPD8 SRP72 TTC3 IFIT1B PRKDC RGPD5

5.78e-041651166PS50293
DomainTPR

RGPD8 SRP72 TTC3 IFIT1B PRKDC RGPD5

5.78e-041651166PS50005
DomainCullin_CS

CUL4B CUL1

7.87e-0471162IPR016157
DomainRab_bind

RGPD8 GCC2

7.87e-0471162PF16704
DomainCULLIN

CUL4B CUL1

7.87e-0471162SM00182
DomainGCC2_Rab_bind

RGPD8 GCC2

7.87e-0471162IPR032023
DomainCullin_neddylation_domain

CUL4B CUL1

1.04e-0381162IPR019559
DomainCullin_Nedd8

CUL4B CUL1

1.04e-0381162PF10557
DomainCullin_Nedd8

CUL4B CUL1

1.04e-0381162SM00884
DomainCullin_homology

CUL4B CUL1

1.34e-0391162IPR016158
DomainBROMODOMAIN_1

BRD3 BRD2 BRD4

1.56e-03371163PS00633
DomainCullin

CUL4B CUL1

1.67e-03101162PF00888
DomainCULLIN_2

CUL4B CUL1

1.67e-03101162PS50069
DomainEF-hand_4

ITSN1 ITSN2

1.67e-03101162PF12763
DomainCullin_N

CUL4B CUL1

1.67e-03101162IPR001373
DomainCULLIN_1

CUL4B CUL1

1.67e-03101162PS01256
Domain-

RGPD8 GCC2

1.67e-031011621.10.220.60
DomainBromodomain

BRD3 BRD2 BRD4

1.68e-03381163PF00439
DomainEH

ITSN1 ITSN2

2.03e-03111162PS50031
DomainEH

ITSN1 ITSN2

2.03e-03111162SM00027
DomainEH_dom

ITSN1 ITSN2

2.03e-03111162IPR000261
DomainBROMODOMAIN_2

BRD3 BRD2 BRD4

2.10e-03411163PS50014
DomainBromodomain

BRD3 BRD2 BRD4

2.25e-03421163IPR001487
DomainBROMO

BRD3 BRD2 BRD4

2.25e-03421163SM00297
Domain-

BRD3 BRD2 BRD4

2.25e-034211631.20.920.10
DomainTPR_1

RGPD8 SRP72 TTC3 RGPD5

2.39e-03901164IPR001440
DomainTPR_1

RGPD8 SRP72 TTC3 RGPD5

2.39e-03901164PF00515
DomainRan_BP1

RGPD8 RGPD5

2.42e-03121162PF00638
DomainRANBD1

RGPD8 RGPD5

2.42e-03121162PS50196
DomainCullin_repeat-like_dom

CUL4B CUL1

2.42e-03121162IPR016159
Domain-

ASTE1 FCF1

2.42e-031211623.40.50.1010
DomainRanBD

RGPD8 RGPD5

2.85e-03131162SM00160
DomainRan_bind_dom

RGPD8 RGPD5

2.85e-03131162IPR000156
DomainPH

ITSN1 SPTBN1 CIT ITK AFAP1L1 ITSN2

3.08e-032291166PF00169
DomainPIN_domain-like

ASTE1 FCF1

3.31e-03141162IPR029060
DomainTPR-like_helical_dom

RGPD8 SRP72 TTC3 IFIT1B PRKDC RGPD5

3.35e-032331166IPR011990
DomainPI3/4_kinase_CS

PRKDC ATM

3.81e-03151162IPR018936
DomainSpectrin_alpha_SH3

ITK ITSN2

3.81e-03151162IPR013315
DomainGproteinA_insert

GNA12 GNAL

4.34e-03161162IPR011025
Domain-

PRKDC ATM

4.34e-031611621.10.1070.11
Domain-

GNA12 GNAL

4.34e-031611621.10.400.10
DomainPI3Kc

PRKDC ATM

4.34e-03161162SM00146
DomainG-alpha

GNA12 GNAL

4.34e-03161162PF00503
DomainG_alpha

GNA12 GNAL

4.34e-03161162SM00275
DomainGprotein_alpha_su

GNA12 GNAL

4.89e-03171162IPR001019
DomainPI3_PI4_kinase

PRKDC ATM

5.48e-03181162PF00454
DomainPI3_4_KINASE_1

PRKDC ATM

5.48e-03181162PS00915
DomainPI3_4_KINASE_2

PRKDC ATM

5.48e-03181162PS00916
DomainPI3/4_kinase_cat_dom

PRKDC ATM

5.48e-03181162IPR000403
DomainPI3_4_KINASE_3

PRKDC ATM

5.48e-03181162PS50290
Domain-

ITSN1 HRNR EFCAB9 RASGRP3 ITSN2 PLCB2

5.81e-0326111661.10.238.10
PathwayREACTOME_MITOTIC_PROMETAPHASE

PDS5B RGPD8 OFD1 CEP290 NCAPG DYNC1LI1 PDS5A PMF1

2.66e-05202848MM15362
PathwayREACTOME_CELL_CYCLE

CUL1 PDS5B RGPD8 OFD1 RTEL1 POLE CEP290 NCAPG2 NCAPG DYNC1LI1 PDS5A ATM PMF1

5.39e-056038413MM14635
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

CUL4B PDS5B RGPD8 COG7 KIF4A IKBIP FBXL3 TLK1 INF2 WASHC5 ZNF644 ITSN2 DYNC1LI1 PDS5A GNAL PRKDC ATM PMF1 RGPD5 KPNA2

2.86e-0911551202020360068
Pubmed

Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system.

BRD3 BRD2 BRD4

4.01e-083120331792058
Pubmed

Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.

BRD3 BRD2 BRD4

4.01e-083120324049186
Pubmed

BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-Mesenchymal Transition.

BRD3 BRD2 BRD4

4.01e-083120329437854
Pubmed

Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.

CUL1 BRD3 BRD2 BRD4

4.37e-0811120428805820
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

CUL4B PDS5B KMT2B ITSN1 SPTBN1 MED14 FAM76B BRD3 TLK1 BRD2 ZNF644 BRD4 DYNC1LI1 PRKDC ATM

7.73e-087741201515302935
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

CUL1 POLE SPTBN1 KIF4A SRP72 NCAPG IPO9 BRD2 BRD4 DYNC1LI1 PRKDC ATM KPNA2

1.21e-075821201320467437
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

PDS5B SPTBN1 KIF4A SRP72 BRD3 NCAPG BRD2 BRD4 DYNC1LI1 PDS5A PRKDC

1.32e-073941201127248496
Pubmed

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors.

BRD3 BRD2 BRD4

1.60e-074120322912406
Pubmed

Expression of BET genes in testis of men with different spermatogenic impairments.

BRD3 BRD2 BRD4

1.60e-074120322035730
Pubmed

Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins.

BRD3 BRD2 BRD4

1.60e-074120324248598
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

RPL23A PDS5B SPTBN1 MED14 FAM76B SRP72 BRD3 HRNR BRD2 BRD4 NEMF DYNC1LI1 PDS5A GNA12 PRKDC ATM KPNA2

1.98e-0710821201738697112
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

CUL1 PDS5B KMT2B MED14 FAM76B KIF4A SRP72 CIT NCAPG2 TLK1 ZNF644 BRD4 SEPTIN14 MED22 DYNC1LI1 PDS5A PRKDC

2.59e-0711031201734189442
Pubmed

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

BRD3 BRD2 INF2 GCC2 BRD4

2.69e-0740120528805822
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

KMT2B VPS13C ITSN1 CEP290 ADGRB1 BRD3 HRNR CCDC39 ITPR2 TRIM43B PDS5A PRKDC ATM RGL4

2.71e-077361201429676528
Pubmed

Defining the membrane proteome of NK cells.

OFD1 CEP290 MED14 KIF4A CIT NCAPG2 IKBIP ITPR2 NCAPG IPO9 GCC2 HS2ST1 LRRC8A DYNC1LI1 PRKDC CMTM7 KPNA2

5.74e-0711681201719946888
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

CUL4B PDS5B POLE CEP290 BRD3 IKBIP NCAPG BRD2 BRD4 PDS5A KPNA2

7.40e-074691201127634302
Pubmed

Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins.

BRD3 BRD2 BRD4

7.95e-076120331444232
Pubmed

Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).

CUL4B KIF4A BRD3 NCAPG2 TLK1

1.36e-0655120527114453
Pubmed

BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail.

BRD3 BRD2 BRD4

2.22e-068120331311807
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

RPL23A CEP104 PDS5B RGPD8 ITSN1 SPTBN1 SRP72 TRIM43 BRD3 TTC3 TRIM43B TLK1 BRD2 ITSN2 GNA12 PRKDC ATM RGPD5

2.32e-0614421201835575683
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

CUL4B CUL1 PDS5B ABCB7 COG7 MED14 NCAPG IPO9 HS2ST1 DYNC1LI1 PDS5A

4.08e-065601201135241646
Pubmed

In vitro nuclear interactome of the HIV-1 Tat protein.

PDS5B BRD3 NCAPG BRD2 DYNC1LI1 PDS5A KPNA2

5.45e-06195120719454010
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

RGPD8 KIF4A SRP72 GIT2 NCAPG2 NCAPG DYNC1LI1 TRAF3IP3 ATM

5.87e-06370120922922362
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

HDAC9 RTEL1 CEP290 GPD1L TLK1 IPO9 RASGRP3 TLR1 DNAH17 PDS5A

8.64e-064931201015368895
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

KIF4A CIT NCAPG2 NCAPG DYNC1LI1 PRKDC KPNA2

8.84e-06210120716565220
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

PDS5B KMT2B KIF4A BRD3 FSIP2 BRD2 ZNF644 BRD4 PDS5A PMF1 KPNA2

8.85e-066081201136089195
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

CUL4B CUL1 PDS5B POLE MED14 KIF4A BRD3 NCAPG BRD2 BRD4 MED22 PDS5A PRKDC ATM

1.12e-0510141201432416067
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

CUL1 ADGRB1 SRP72 FBP2 HRNR GPD1L IPO9 WASHC5

1.12e-05304120832235678
Pubmed

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.

RPL23A RGPD8 ITSN1 SPTBN1 KIF4A HRNR ITPR2 INF2 ITSN2 PRKDC RGPD5

1.16e-056261201133644029
Pubmed

Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha).

ITK KPNA2

1.18e-052120211581171
Pubmed

Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis.

PRKDC ATM

1.18e-052120211231155
Pubmed

Intersectin deficiency impairs cortico-striatal neurotransmission and causes obsessive-compulsive behaviors in mice.

ITSN1 ITSN2

1.18e-052120237603735
Pubmed

Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation.

PRKDC ATM

1.18e-052120210464290
Pubmed

Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.

PRKDC ATM

1.18e-052120227939942
Pubmed

CEP104 and CEP290; Genes with Ciliary Functions Cause Intellectual Disability in Multiple Families.

CEP104 CEP290

1.18e-052120234196201
Pubmed

The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.

PRKDC ATM

1.18e-052120221487018
Pubmed

Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation.

BRD2 BRD4

1.18e-052120232151278
Pubmed

Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.

ITSN1 ITSN2

1.18e-052120231031201
Pubmed

PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.

PDS5B PDS5A

1.18e-052120231757807
Pubmed

Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.

PRKDC ATM

1.18e-052120226057167
Pubmed

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.

BRD2 BRD4

1.18e-052120223255218
Pubmed

Intersectin associates with synapsin and regulates its nanoscale localization and function.

ITSN1 ITSN2

1.18e-052120229078407
Pubmed

A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.

BRD2 BRD4

1.18e-052120224146614
Pubmed

PDS5A and PDS5B in Cohesin Function and Human Disease.

PDS5B PDS5A

1.18e-052120234070827
Pubmed

The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription.

BRD3 BRD2

1.18e-052120218406326
Pubmed

DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases.

PRKDC ATM

1.18e-052120219071136
Pubmed

Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition.

ITSN1 ITSN2

1.18e-052120223447614
Pubmed

Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.

PRKDC ATM

1.18e-052120212065055
Pubmed

Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2.

BRD2 BRD4

1.18e-052120235839775
Pubmed

Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

PRKDC ATM

1.18e-052120217189255
Pubmed

The human intersectin genes and their spliced variants are differentially expressed.

ITSN1 ITSN2

1.18e-052120211690630
Pubmed

AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.

PRKDC ATM

1.18e-052120222972376
Pubmed

G(2)-M phase-correlative bystander effects are co-mediated by DNA-PKcs and ATM after carbon ion irradiation.

PRKDC ATM

1.18e-052120226774662
Pubmed

WHAT do viruses BET on?

BRD2 BRD4

1.18e-052120220036832
Pubmed

DNA-PKcs and ATM modulate mitochondrial ADP-ATP exchange as an oxidative stress checkpoint mechanism.

PRKDC ATM

1.18e-052120236727301
Pubmed

PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.

PDS5B PDS5A

1.18e-052120235986423
Pubmed

Deciphering the role of distinct DNA-PK phosphorylations at collapsed replication forks.

PRKDC ATM

1.18e-052120232674014
Pubmed

Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene.

BRD3 BRD2

1.18e-05212029373153
Pubmed

Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.

ITSN1 ITSN2

1.18e-052120223936226
Pubmed

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis.

BRD3 BRD4

1.18e-052120228733670
Pubmed

BET bromodomain proteins mediate downstream signaling events following growth factor stimulation in human lung fibroblasts and are involved in bleomycin-induced pulmonary fibrosis.

BRD2 BRD4

1.18e-052120223115324
Pubmed

Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.

PRKDC ATM

1.18e-052120221245310
Pubmed

Bromodomain and extra-terminal domain bromodomain inhibition prevents synovial inflammation via blocking IκB kinase-dependent NF-κB activation in rheumatoid fibroblast-like synoviocytes.

BRD2 BRD4

1.18e-052120226324948
Pubmed

The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase.

PRKDC ATM

1.18e-052120217593081
Pubmed

Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation.

PRKDC ATM

1.18e-052120220617180
Pubmed

Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification.

BRD2 BRD4

1.18e-052120228588073
Pubmed

Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression.

BRD3 BRD4

1.18e-052120230786900
Pubmed

DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.

PRKDC ATM

1.18e-052120218172300
Pubmed

Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes.

BRD2 BRD4

1.18e-052120216940503
Pubmed

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells.

BRD3 BRD4

1.18e-052120229240787
Pubmed

SARS-CoV-2 E protein interacts with BRD2 and BRD4 SEED domains and alters transcription in a different way than BET inhibition.

BRD2 BRD4

1.18e-052120239066826
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

PDS5B RTEL1 NCAPG2 BRD2 ZNF644 BRD4 PDS5A

1.27e-05222120737071664
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

CUL4B RPL23A CUL1 COG7 SPTBN1 NCAPG IPO9 DYNC1LI1 PDS5A PRKDC KPNA2

1.39e-056381201133239621
Pubmed

Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.

GMCL1 PRKDC ATM

1.77e-0515120317010969
Pubmed

Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.

ABCB7 SPTBN1 CIT IKBIP IPO9 LRRC8A

1.77e-05156120629961565
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

PDS5B POLE ARFGEF1 SRP72 NCAPG2 NCAPG IPO9 INF2 HS2ST1 DYNC1LI1 PDS5A PRKDC KPNA2

2.36e-059421201331073040
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

KMT2B OFD1 POLE MED14 TTC3 CIT MXRA7 ITPR2 TLK1 BRD2 INF2 BRD4 GNA12 PRKDC

2.89e-0511051201435748872
Pubmed

SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.

CREB5 BRD2 INF2

3.15e-0518120329996942
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

RPL23A CUL1 PDS5B VPS13C POLE SPTBN1 SRP72 TTC3 NCAPG IPO9 NEMF DYNC1LI1 PDS5A PRKDC ATM KPNA2

3.25e-0514251201630948266
Pubmed

Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain.

ITSN1 ITSN2

3.53e-053120231718706
Pubmed

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

PRKDC ATM

3.53e-05312029766667
Pubmed

Identification and characterization of FUS/TLS as a new target of ATM.

PRKDC ATM

3.53e-053120218620545
Pubmed

Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways.

PRKDC ATM

3.53e-053120230224064
Pubmed

DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.

PRKDC ATM

3.53e-053120218644470
Pubmed

Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility.

PRKDC ATM

3.53e-053120218451257
Pubmed

Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.

PRKDC ATM

3.53e-053120223836881
Pubmed

DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells.

PRKDC ATM

3.53e-053120227733644
Pubmed

Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis.

ITSN1 ITSN2

3.53e-053120210922467
Pubmed

Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ.

PRKDC ATM

3.53e-053120217923115
Pubmed

DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system.

PRKDC ATM

3.53e-053120229101015
Pubmed

NF-κB signaling activation via increases in BRD2 and BRD4 confers resistance to the bromodomain inhibitor I-BET151 in U937 cells.

BRD2 BRD4

3.53e-053120230300821
Pubmed

DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells.

PRKDC ATM

3.53e-053120231601897
Pubmed

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.

BRD2 BRD4

3.53e-053120228262505
Pubmed

Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.

RSPH4A CCDC39

3.53e-053120223255504
Pubmed

BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.

BRD3 BRD4

3.53e-053120217934517
Pubmed

Structural mechanism of nuclear transport mediated by importin β and flexible amphiphilic proteins.

CUL4B CUL1

3.53e-053120225435324
Pubmed

Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors.

BRD2 BRD4

3.53e-053120225049379
Pubmed

Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy.

PRKDC ATM

3.53e-053120225205036
Pubmed

Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.

PDS5B PDS5A

3.53e-053120228343969
InteractionPWWP2B interactions

BRD3 BRD2 BRD4 PRKDC

3.10e-06181174int:PWWP2B
InteractionRGPD8 interactions

RGPD8 INF2 TRAF3IP3 PMF1 RGPD5 KPNA2

4.52e-06741176int:RGPD8
InteractionUHRF2 interactions

CUL4B KIF4A BRD3 CIT NCAPG2 TLK1 BRD4 PRKDC

2.21e-052001178int:UHRF2
InteractionRCC1 interactions

HDAC9 KMT2B RGPD8 BRD3 CIT BRD2 BRD4 RGPD5

2.29e-052011178int:RCC1
InteractionCCDC42 interactions

MID2 CIT CCDC42

3.04e-05111173int:CCDC42
InteractionSMC1A interactions

CUL4B PDS5B POLE ITSN1 TRIM43 CIT BRD4 NEMF PDS5A PRKDC ATM

3.24e-0541811711int:SMC1A
InteractionH2AC4 interactions

CUL4B CUL1 PDS5B SPTBN1 SRP72 CIT NCAPG IPO9 BRD2 BRD4 DYNC1LI1 PRKDC

3.87e-0550611712int:H2AC4
InteractionSPDYE7P interactions

BRD3 BRD2 BRD4

4.04e-05121173int:SPDYE7P
InteractionDISC1 interactions

ABCB7 RGPD8 OFD1 ITSN1 SPTBN1 CEP290 CIT IKBIP IPO9 LRRC8A RGPD5

4.11e-0542911711int:DISC1
InteractionGPR17 interactions

PDS5B COG7 ARFGEF1 ITPR2 GPD1L NCAPG PDS5A PRKDC ATM

4.11e-052831179int:GPR17
InteractionCBX5 interactions

CUL4B RPL23A HDAC9 BRD3 CIT BRD2 ZNF644 BRD4 PMF1 KPNA2

4.36e-0535611710int:CBX5
InteractionZNF711 interactions

RPL23A BRD3 BRD2 BRD4

4.37e-05341174int:ZNF711
InteractionCBX1 interactions

CUL4B BRD3 CIT IPO9 BRD2 ZNF644 BRD4 PMF1 KPNA2

4.71e-052881179int:CBX1
InteractionLPAR4 interactions

PDS5B PDS5A PRKDC ATM

5.51e-05361174int:LPAR4
InteractionZNF330 interactions

PDS5B KMT2B POLE KIF4A BRD3 CREB5 IPO9 BRD2 ZNF644 PDS5A KPNA2

5.83e-0544611711int:ZNF330
InteractionDHX38 interactions

BRD3 CIT ITGB3 BRD2 BRD4 IFIT1B PRKDC

6.11e-051701177int:DHX38
InteractionH3C1 interactions

CUL4B PDS5B KMT2B CEP290 MED14 KIF4A SRP72 BRD3 TLK1 BRD2 GCC2 ZNF644 BRD4 PDS5A PRKDC ATM

6.51e-0590111716int:H3C1
InteractionXRCC1 interactions

CUL1 BRD3 CIT NCAPG BRD2 BRD4 PRKDC

6.83e-051731177int:XRCC1
InteractionTNFSF13B interactions

NCAPG2 MALT1 NCAPG IPO9 PDS5A PRKDC

6.85e-051191176int:TNFSF13B
InteractionSMARCA4 interactions

CUL4B CUL1 HDAC9 BRD3 TTC3 CIT BRD2 BRD4 ATM TBX20 KPNA2

7.98e-0546211711int:SMARCA4
InteractionPCNT interactions

OFD1 SPTBN1 CEP290 TRIM43 IKBIP IPO9 DYNC1LI1 TMOD1

8.28e-052411178int:PCNT
InteractionRNF123 interactions

KMT2B VPS13C ITSN1 CEP290 ADGRB1 BRD3 HRNR CCDC39 ITPR2 TRIM43B INF2 PDS5A PRKDC ATM RGL4

8.53e-0582411715int:RNF123
InteractionRPS7 interactions

CUL4B RPL23A CUL1 ABCB7 VPS13C SRP72 CIT ITPR2 BRD4 NEMF DYNC1LI1

8.61e-0546611711int:RPS7
InteractionFAM234A interactions

PDS5B COG7 ARFGEF1 PDS5A PRKDC ATM

9.41e-051261176int:FAM234A
InteractionCD80 interactions

PDS5B GPD1L PDS5A PRKDC ATM

9.68e-05791175int:CD80
InteractionSREK1 interactions

CUL4B RPL23A CUL1 SPTBN1 CEP290 BRD3 CIT

9.71e-051831177int:SREK1
InteractionCBX3 interactions

CUL4B CUL1 HDAC9 PDS5B KMT2B KIF4A BRD3 CIT BRD2 ZNF644 BRD4 PDS5A PMF1

9.74e-0564611713int:CBX3
InteractionMED24 interactions

MED14 BRD3 BRD2 BRD4 MED22 SUCO

1.03e-041281176int:MED24
InteractionHSP90B1 interactions

CUL4B CUL1 RELCH VPS13C SPTBN1 CIT ITGB3 IPO9 BRD4 TLR1 DNAH17 NEMF LRRC8A

1.04e-0465011713int:HSP90B1
InteractionNOVA2 interactions

BRD3 BRD2 BRD4

1.22e-04171173int:NOVA2
InteractionNHEJ1 interactions

BRD4 PRKDC ATM

1.22e-04171173int:NHEJ1
InteractionRPL35A interactions

CUL4B RPL23A CUL1 PDS5B SRP72 BRD3 CIT BRD4 TMOD1 PDS5A

1.27e-0440511710int:RPL35A
InteractionMED30 interactions

MED14 BRD3 BRD2 BRD4 MED22

1.30e-04841175int:MED30
InteractionPOLR1G interactions

CUL1 PDS5B KMT2B BRD3 CIT NCAPG2 BRD2 ZNF644 BRD4 PDS5A KPNA2

1.32e-0448911711int:POLR1G
InteractionAATK interactions

CUL1 RELCH ITSN1 WASHC5 GCC2 ITSN2 PRKDC

1.40e-041941177int:AATK
InteractionC19orf38 interactions

PDS5B NCAPG2 NCAPG PDS5A PRKDC

1.45e-04861175int:C19orf38
InteractionMAS1 interactions

PDS5B NCAPG PDS5A PRKDC ATM

1.45e-04861175int:MAS1
InteractionNPIPB6 interactions

RGPD8 RGPD5 KPNA2

1.46e-04181173int:NPIPB6
InteractionH3C3 interactions

PDS5B KMT2B KIF4A BRD3 FSIP2 BRD2 ZNF644 BRD4 PDS5A PMF1 KPNA2

1.46e-0449511711int:H3C3
InteractionCFAP410 interactions

CEP104 CUL1 CEP290 GMCL1

1.87e-04491174int:CFAP410
InteractionDNAJC7 interactions

RPL23A OFD1 VPS13C POLE TTC3 NCAPG2 BRD2 BRD4 PRKDC ATM

1.88e-0442511710int:DNAJC7
InteractionMED1 interactions

MED14 BRD3 CIT BRD2 BRD4 MED22 ATM

2.02e-042061177int:MED1
InteractionCTDP1 interactions

ABCB7 MED14 ARFGEF1 CIT NCAPG2 PRKDC ATM

2.08e-042071177int:CTDP1
InteractionUHRF1 interactions

CUL1 BRD3 CIT IPO9 BRD2 BRD4 ATM

2.14e-042081177int:UHRF1
InteractionKPNA2 interactions

CUL4B CUL1 RGPD8 MROH2A CIT ITK GMCL1 NCAPG BRD4 RGPD5 KPNA2

2.21e-0451911711int:KPNA2
InteractionOPALIN interactions

PDS5B ABCB7 ARFGEF1 NCAPG2 PDS5A PRKDC ATM

2.21e-042091177int:OPALIN
InteractionPSMD2 interactions

RGPD8 OFD1 MID2 CIT ITGB3 IPO9 GCC2 BRD4 PDS5A RGPD5

2.26e-0443511710int:PSMD2
InteractionST7 interactions

CUL4B PCDHB6 IKBIP MXRA7 ITPR2 ZFYVE9 INF2 SUCO MCOLN3

2.65e-043621179int:ST7
InteractionCEBPA interactions

CUL1 PDS5B KMT2B SPTBN1 MED14 FAM76B KIF4A SRP72 CIT NCAPG2 TLK1 ZNF644 BRD4 SEPTIN14 MED22 DYNC1LI1 PDS5A PRKDC

2.96e-04124511718int:CEBPA
InteractionMED4 interactions

OFD1 ITSN1 CEP290 MED14 BRD3 GIT2 NCAPG BRD4 MED22 RGPD5

2.96e-0445011710int:MED4
InteractionCHAF1B interactions

BRD3 CIT BRD2 ZNF644 BRD4 PMF1

3.23e-041581176int:CHAF1B
InteractionPOLR2H interactions

CUL1 MED14 BRD3 BRD4 MED22 PRKDC KPNA2

3.27e-042231177int:POLR2H
InteractionSNAI1 interactions

CUL4B RPL23A CUL1 MID2 BRD3 NCAPG IPO9 BRD2 BRD4 PRKDC ATM

3.40e-0454611711int:SNAI1
InteractionTFPT interactions

MID2 BRD3 GIT2 BRD2 GCC2 RGPD5

3.45e-041601176int:TFPT
InteractionCENPA interactions

PDS5B KMT2B POLE KIF4A BRD3 BRD2 ZNF644 PDS5A PRKDC

3.57e-043771179int:CENPA
InteractionHAUS6 interactions

CEP104 OFD1 CEP290 GIT2 CIT INF2

3.57e-041611176int:HAUS6
InteractionMED19 interactions

MED14 BRD3 BRD2 BRD4 MED22

3.85e-041061175int:MED19
InteractionZNF740 interactions

BRD3 BRD2 BRD4

4.00e-04251173int:ZNF740
InteractionSNW1 interactions

CUL4B CUL1 POLE SPTBN1 KIF4A SRP72 CIT NCAPG IPO9 BRD4 PRKDC ATM KPNA2

4.01e-0474711713int:SNW1
InteractionRFC1 interactions

CUL1 POLE BRD3 BRD2 BRD4 PDS5A ATM

4.05e-042311177int:RFC1
InteractionRAD21 interactions

RPL23A PDS5B TRIM43 CIT NCAPG BRD4 PDS5A PRKDC KPNA2

4.08e-043841179int:RAD21
InteractionMYH9 interactions

CUL1 SPTBN1 ARFGEF1 CIT ITGB3 ITPR2 FCF1 NCAPG CCDC42 INF2 BRD4 TMOD1 KPNA2

4.38e-0475411713int:MYH9
InteractionMECP2 interactions

RPL23A PDS5B SPTBN1 MED14 FAM76B SRP72 BRD3 HRNR FCF1 BRD2 BRD4 NEMF DYNC1LI1 PDS5A GNA12 PRKDC ATM KPNA2

4.41e-04128711718int:MECP2
Cytoband3p22.3

GPD1L DYNC1LI1 CMTM7

7.42e-053112033p22.3
Cytoband9q22.3

FBP2 TMOD1

4.40e-041212029q22.3
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD8 SRP72 TTC3 IFIT1B RGPD5

1.02e-04115735769
GeneFamilyCullins

CUL4B CUL1

4.43e-0487321032
GeneFamilyEF-hand domain containing

ITSN1 HRNR EFCAB9 RASGRP3 ITSN2

1.92e-03219735863
GeneFamilyArmadillo repeat containing|Importins

IPO9 KPNA2

2.36e-0318732596
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

CUL4B PDS5B VPS13C CEP290 ARFGEF1 FBXL3 ITPR2 WASHC5 GCC2 ZNF644 ITSN2 NEMF ATM SUCO

1.74e-0665611914M18979
CoexpressionMITSIADES_RESPONSE_TO_APLIDIN_DN

HDAC9 PDS5B SPTBN1 KIF4A TTC3 NCAPG2 NCAPG PDS5A PRKDC

2.20e-062501199M11318
CoexpressionAtlasgamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2

POLE MED14 KIF4A TTC3 CIT ITGB3 NCAPG2 ITK NCAPG MCOLN3 KPNA2

1.72e-0542211411GSM476658_500
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3

ABCB7 VPS13C POLE CEP290 TTC3 CIT NCAPG NEMF LRRC8A PDS5A PRKDC ATM

2.94e-0553211412Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

CUL1 VPS13C CEP290 TTC3 TLK1 GCC2 ZNF644 BRD4 KPNA2

3.29e-09198119976d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

CEP104 VPS13C CEP290 TTC3 CCDC39 GCC2 ZNF644 BRD4 NEMF

3.44e-09199119961b1ed2db71b96157b92b7535d1955a4033098da
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

VPS13C CEP290 ARFGEF1 TTC3 GCC2 ZNF644 BRD4 ITSN2

6.56e-081991198c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 TTC3 ITK GCC2 ITSN2 PDS5A SUCO

6.04e-071821197e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 TTC3 ITK GCC2 ITSN2 PDS5A SUCO

6.04e-0718211971710eab3037a87609d21838be2d2d29c3bc36651
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

PDS5B POLE KIF4A CIT NCAPG2 NCAPG IPO9

8.06e-071901197d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLVAP POLE KIF4A CIT NCAPG2 NCAPG PMF1

9.59e-0719511975790b47b0e028e49b99bda8d6d9e80ac79208cdf
ToppCellCOVID_non-vent-Lymphocytic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

OFD1 SPTBN1 TTC3 ITK GCC2 TRAF3IP3 ATM

1.03e-061971197c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

CEP104 VPS13C ITSN1 CEP290 TTC3 GCC2 BRD4

1.10e-061991197fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellP15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

POLE TBC1D7 MED14 KIF4A CIT NCAPG

6.94e-0617211967c238a7375341d4647ba7274d93fddfb6fae7ce4
ToppCellnormal-na-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

NBEAL1 SPTBN1 ITK GCC2 IFIT1B ATM

8.45e-061781196fa3585383a1e7da460c88a802aaa81246d681b6b
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POLE CEP290 NCAPG2 AOC3 PDE5A ATM

9.29e-061811196274c0b768925cd5804483303f8c5ebd17a534c41
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF4A CIT NCAPG2 NCAPG INF2 KPNA2

1.02e-051841196a0831e850bc0b585296ed350fdd075c1f730308e
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l33-52|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCA13 POLE KIF4A NCAPG2 NCAPG GRAMD1C

1.05e-05185119647c69500877b851c0c9744f5e1ef2ee0bff99168
ToppCellControl-Endothelial-Endothelial-FOXM1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

POLE KIF4A CIT NCAPG2 NCAPG KPNA2

1.19e-0518911961e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCell(02)_Cycling_Basal_(regeneration)|World / shred by cell type and Timepoint

POLE KIF4A NCAPG2 NCAPG PMF1 KPNA2

1.22e-05190119653f017a11ca5ebe9025558e12cedc409cab2e5aa
ToppCellEndothelial-D_(cycle)|World / shred on cell class and cell subclass (v4)

PLVAP KIF4A CIT NCAPG2 NCAPG KPNA2

1.26e-05191119649a4d8f181558e3be9527a8ff9a178f3bb01323c
ToppCellE17.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLVAP KIF4A CIT NCAPG RASGRP3 KPNA2

1.26e-051911196efe0cb0b6602621f5eda72a723b83b38bf15607f
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KIF4A CIT NCAPG2 IKBIP NCAPG KPNA2

1.26e-0519111960ba5b112a82e489f5a21966f78a403a7436ce73b
ToppCellE17.5-Endothelial-proliferative_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLVAP KIF4A CIT NCAPG RASGRP3 KPNA2

1.26e-05191119600676c598f6dae0ff9158d064248f1265432f3e1
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KIF4A CIT NCAPG2 NCAPG PDE5A KPNA2

1.26e-051911196f764cc21fef87ebad765011098f647ae1bdf6158
ToppCellASK428-Immune-T_cell|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

RPL23A NBEAL1 ITK P2RY10 TRAF3IP3 RGL4

1.30e-051921196121cb8c61002f20e1d287b8a7e67a30bb163e74a
ToppCelldroplet-Skin-nan-21m-Epithelial-stem_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF4A CIT NCAPG2 NCAPG PMF1 KPNA2

1.30e-05192119696f23d6e8604d1cb24910d3118d8171b57c93e14
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLVAP MID2 SPTBN1 AFAP1L1 GCC2 RASGRP3

1.30e-0519211964bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCelldroplet-Pancreas-Exocrine-18m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF4A ITGB3 CREB5 MXRA7 AFAP1L1 NCAPG

1.30e-051921196a42aed9e563f5f4af029b8804c104f11ad227a8f
ToppCellProliferating|World / shred by cell class for mouse tongue

KIF4A CIT NCAPG2 NCAPG PMF1 KPNA2

1.30e-051921196f081f3f957cc782294e118fcc1055f6a4264ee98
ToppCellP07-Endothelial-proliferative_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLVAP KIF4A CIT NCAPG2 NCAPG KPNA2

1.34e-0519311961e95ef29357969ee385b4717c0b5a497390ac260
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

CUL4B NBEAL1 SRP72 GCC2 PDS5A PRKDC

1.34e-051931196abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellcontrol-Myeloid-Immature_Neutrophils_2|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ABCA13 POLE KIF4A CIT NCAPG RGL4

1.34e-05193119633349830e9eba506470ad3661fad5e5a283d20ca
ToppCellP07-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLVAP KIF4A CIT NCAPG2 NCAPG KPNA2

1.34e-0519311960f21fb8b35f89f4c1c8109d1a4d3d08a452f9edd
ToppCelldroplet-Tongue-nan-3m-Epithelial-proliferating|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF4A CIT NCAPG2 NCAPG PMF1 KPNA2

1.38e-0519411962cac1b9c4da01faaec9a67ec06f47a7060760225
ToppCell(3)_Chondrocytes-(33)_Chondro-prol/rest|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis

KIF4A CIT NCAPG2 NCAPG CMTM7 PMF1

1.38e-0519411964a207630d72059345b10010f5cfd3b1462458324
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLVAP POLE KIF4A CIT NCAPG2 NCAPG

1.38e-0519411963a49c7c86036e09a8cd0114988380d04ad1a26fb
ToppCellCOVID_non-vent-Lymphocytic-T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SPTBN1 TTC3 ITK GCC2 TRAF3IP3 ATM

1.42e-0519511964bdedd924564a260841a9153604026b57487c83d
ToppCellBronchial-NucSeq-Immune_Myeloid-Dendritic_cell-DC_1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HDAC9 KIF4A NCAPG TLR1 PLCB2 TBX20

1.46e-05196119653d1f9e9f009d1417a19ca6f9a83ecdf7776ef88
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLVAP KIF4A CIT NCAPG2 NCAPG RASGRP3

1.46e-05196119620383d576708b7e4bfce3e9fe40548cce496e3cb
ToppCellCOVID-19-lung-Proliferative_fibroblast|COVID-19 / Disease (COVID-19 only), tissue and cell type

KIF4A TDO2 CIT NCAPG2 NCAPG KPNA2

1.46e-051961196ca91d5e325875e7444809b80fcbd491d8899ea36
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLVAP KIF4A CIT NCAPG2 NCAPG RASGRP3

1.46e-0519611960644bd14a944b9c9759a295dfdd5e67a4775f20a
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_naive|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RPL23A NBEAL1 ITK GCC2 TRAF3IP3 ATM

1.50e-0519711969373fcd728016b7af1abd7d88c47b7db79eb6a2f
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLVAP KIF4A CIT NCAPG2 NCAPG RASGRP3

1.50e-051971196a41420d4b6d502c2f594c054c7efbb5d4eac83ff
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD4+_Naive_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ENOSF1 SPTBN1 TTC3 ITK GCC2 ATM

1.50e-051971196836dd8110d5689f944ad1d301def38c32278b5b5
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-Treg|ICU-SEP / Disease, condition lineage and cell class

FSIP2 INF2 P2RY10 TRAF3IP3 RGPD5 RGL4

1.50e-051971196c3ee2d522fbfe67069ddba2d1abfc4f5ca230c26
ToppCellnormal-na-Lymphocytic_T-T8_naive|normal / PBMC cell types (v2) per disease, treatment status, and sex

RPL23A NBEAL1 ITK GCC2 ATM RGL4

1.55e-05198119661b7e313967acff0a7cfc0a797f78494d3d08e29
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_naive-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RPL23A NBEAL1 ITK GCC2 TRAF3IP3 ATM

1.55e-051981196239bef79ebaa6e1d8618c670c1050a02362058ee
ToppCellsevere-Myeloid-Immature_Neutrophils_2|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ABCA13 POLE KIF4A CIT NCAPG2 NCAPG

1.55e-051981196844f534551483c89ef789d1cfeb4680e54f794b2
ToppCellsevere-Myeloid-Immature_Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ABCA13 POLE KIF4A CIT NCAPG2 NCAPG

1.55e-051981196e36303628af3139310c1d7a84d2919b7319bbda4
ToppCellnormal-na-Lymphocytic_T-T8_naive-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

RPL23A NBEAL1 ITK GCC2 ATM RGL4

1.55e-051981196ac8e21629991e47796e2c0a201a6d3bd8cd30b85
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA13 KIF4A CIT NCAPG2 NCAPG KPNA2

1.55e-051981196f088badb90c6c2d916195f5649eda102119c9ac6
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLVAP KIF4A AFAP1L1 NCAPG RASGRP3 KPNA2

1.55e-051981196604fb20ca1aaf8f07067a8e1593a30ba335891f7
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RELCH ARFGEF1 ITK ZNF644 ATM RGPD5

1.59e-051991196f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-T8_naive|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

NBEAL1 ITK GCC2 TRAF3IP3 ATM RGL4

1.59e-05199119640eb207fa0f07e2e4d0be69530b8f61f7ea49c73
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

VPS13C CEP290 TTC3 GCC2 BRD4 ITSN2

1.59e-05199119618a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCellHealthy_Control-Lymphoid-T|Healthy_Control / Condition, Lineage, Cell class and cell subclass

KIF4A ITK NCAPG P2RY10 TRAF3IP3 RGL4

1.59e-051991196f22438fc9c02d0a4d7c936f9420b913aca851ea1
ToppCellCOVID_vent-Lymphocytic-T_cell-CD4+_Naive_T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

RPL23A SPTBN1 TTC3 ITK GCC2 ATM

1.59e-051991196885bc902b6e2af0b61e452c4154160cd3f1cf98e
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-CD8+_Tcm|Leuk-UTI / Disease, condition lineage and cell class

RPL23A ENOSF1 RSPH4A TTC3 ITK GCC2

1.59e-0519911966a1d84f61e1efaab541910926d6911122372659f
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-T8_naive-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

NBEAL1 ITK GCC2 TRAF3IP3 ATM RGL4

1.59e-0519911966ed413872301707dc73ae66365bee94cd38a292c
ToppCellControl-Control-Lymphocyte-T/NK-CD8+_T_naive|Control / Disease, condition lineage and cell class

SPTBN1 ITK GCC2 TRAF3IP3 ATM RGL4

1.64e-052001196906de95adc9716982ab32f216dddeb52639bad06
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte-|COVID_vent / Disease condition, Lineage, Cell class and subclass

KIF4A CIT NCAPG2 NCAPG PRKDC KPNA2

1.64e-0520011967e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte|COVID_vent / Disease condition, Lineage, Cell class and subclass

KIF4A CIT NCAPG2 NCAPG PRKDC KPNA2

1.64e-0520011969775ca7dedb76fcbb74f80f86b33c94e394c320a
ToppCellLPS_only-Endothelial-Endothelial-FOXM1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

POLE KIF4A CIT NCAPG2 NCAPG

3.02e-0513411954d8f7ddad02fe76a614771e115ebb8e04623ba85
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MROH2A CIT CREB5 MXRA7 PDE5A

4.41e-051451195590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCell368C-Lymphocytic-NK_cells|368C / Donor, Lineage, Cell class and subclass (all cells)

OFD1 RTEL1 KIF4A NCAPG TRAF3IP3

6.43e-051571195ef5c0ace4cd500b6cc50fb7076298f3d3543b40c
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELCH POLE MROH2A ITK GNAL

8.86e-051681195a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

POLE KIF4A NCAPG2 NCAPG KPNA2

9.11e-051691195b253a4a50c06d36228fcd5d856c57202cbac158f
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIF4A CIT NCAPG2 NCAPG KPNA2

9.11e-051691195e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCellfacs-SCAT-Fat-18m-Lymphocytic-T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INPP5B KIF4A ITK P2RY10 MCOLN3

9.11e-051691195700a3a36c379872585204caa6a6cc269b036ae22
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RSPH4A SPTBN1 PCDHA11 AFAP1L1 TMOD1

9.37e-0517011954848965bc7e9356c6601bb41eeea1553d2eea87e
ToppCellfacs|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2B LRRC8A DYNC1LI1 GNA12 GNAL

9.63e-051711195c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCell5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLVAP SPTBN1 AFAP1L1 EFCAB9 RASGRP3

9.63e-051711195b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HDAC9 MROH2A TBC1D7 CREB5 P2RY10

9.90e-051721195b043d4f81dced7fb3326043f68474123be47cc5d
ToppCellfacs-Heart-RA-3m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MALT1 DNAH17 P2RY10 TRAF3IP3 PMF1

1.02e-04173119549030c2dd04b592655df1a667e2f90efb499e0a5
ToppCellfacs-Heart-RA-3m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MALT1 DNAH17 P2RY10 TRAF3IP3 PMF1

1.02e-0417311951cfbab6603f8baf8e238837bb72740c43a7dc0ec
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLVAP POLE KIF4A NCAPG2 NCAPG

1.04e-041741195c988471207ba06195bc3e41056435e8c31c20bbe
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLVAP KIF4A CIT NCAPG2 NCAPG

1.07e-041751195d43ae33a6256606ce848247cad32d74f21b38988
ToppCellfacs|World / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2B LRRC8A DYNC1LI1 GNA12 GNAL

1.07e-04175119553e96956019f984decc1c81376ebc88fbf3c4d40
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN1 AFAP1L1 RASGRP3 AOC3 TMOD1

1.10e-04176119564e426f5e84884ce2c29acf6f4b958962a63927f
ToppCell(01)_Cycling_Basal_(homeostasis)|World / shred by cell type and Timepoint

KIF4A CIT NCAPG PMF1 KPNA2

1.13e-04177119505c57578142a6662f18b294d5cc11e6efd6b0f8e
ToppCellHealthy-RBC|Healthy / disease group, cell group and cell class

KIF4A CIT NCAPG IFIT1B TMOD1

1.13e-041771195945d72ab52efa9a9468daace9f9ec676a891d963
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_naive-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

NBEAL1 GCC2 TRAF3IP3 ATM RGL4

1.13e-041771195db6de487ef7976b444afadbf3ac60b3259925566
ToppCellP28-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KIF4A CIT NCAPG2 NCAPG KPNA2

1.26e-041811195e482fd116c00ff4d8db7be3c06b1bd1ffa2d479d
ToppCellP28-Endothelial-proliferative_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KIF4A CIT NCAPG2 NCAPG KPNA2

1.26e-0418111952be3d44619adb25d339e7a27b500a56e07e8de01
ToppCellIIH-cycling-|IIH / Condition, Cell_class and T cell subcluster

KIF4A CIT NCAPG2 NCAPG KPNA2

1.26e-0418111957f4fed9e296bc22cb5a1e6c8e3c4b641e97c3078
ToppCellIIH-cycling|IIH / Condition, Cell_class and T cell subcluster

KIF4A CIT NCAPG2 NCAPG KPNA2

1.26e-041811195ec3e782ce93dcfe1a54fb7284e4e39063614b0e2
ToppCellHealthy_Control-Lymphoid-T-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

SPTBN1 KIF4A CIT NCAPG KPNA2

1.26e-041811195ac1ee313910c05b1b3cb497bae14565464919c21
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 KIF4A CIT NCAPG2 NCAPG

1.26e-041811195566249e04dd491e6287ad2101b7b1ab11031ed8b
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 KIF4A CIT NCAPG2 NCAPG

1.26e-041811195db9528dc7cb0230e4c36cb27da69102c588c7ee9
ToppCellLeuk-UTI-Lymphocyte-T_NK-CD8_Naive|Leuk-UTI / Disease, Lineage and Cell Type

ITK AFAP1L1 GCC2 TRAF3IP3 RGL4

1.29e-0418211953500a826d86beb98980e2b24e074b02e8e2f957e
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_A|E18.5-samps / Age Group, Lineage, Cell class and subclass

PLVAP MID2 POLE NCAPG RASGRP3

1.29e-041821195ea4f6c8f600ffe9f8e0609637b3371a5ac48ca03
ToppCelldroplet-Spleen-nan-18m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITPR2 MALT1 RASGRP3 ITSN2 SUCO

1.29e-041821195eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T8_naive-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

NBEAL1 GCC2 TRAF3IP3 ATM RGL4

1.29e-0418211953a3ed195c15d33d46a2f395cb93018e4bba28353
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLVAP AFAP1L1 NCAPG RASGRP3 KPNA2

1.32e-04183119552af3c943116073c8ddd207b664342960b88929b
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCA13 POLE KIF4A NCAPG2 NCAPG

1.32e-0418311956c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCellnormal-na-Lymphocytic_T-T8_naive-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

NBEAL1 ITK GCC2 TRAF3IP3 ATM

1.36e-0418411954a81190b36d197736663e6177d3b76c1cb6282d6
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C SPTBN1 GCC2 ITSN2 PDS5A

1.36e-0418411951154a5ad7b8512272b7476f949ddac350910bfb7
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDS5B VPS13C KIF4A AFAP1L1 DNAH17

1.36e-041841195e7b9c69fc77040c5191ad8089697051e2589c30e
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRD3 TTC3 ITGB3 MXRA7 RASGRP3

1.43e-04186119537860daeecd6d412bd3797f30496a56da667fbd1
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRD3 TTC3 ITGB3 MXRA7 RASGRP3

1.43e-04186119560830822d3de3147816693404fd03392e04c2b8e
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell|TCGA-Uvea / Sample_Type by Project: Shred V9

ITGB3 ITPR2 WASHC5 PRKDC KPNA2

1.43e-041861195e8580a2093eb7e50aad55ec7fada850d2fed8ae1
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRD3 TTC3 ITGB3 MXRA7 RASGRP3

1.43e-041861195baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

NBEAL1 MED14 HNF4G GCC2 ZNF644

1.43e-04186119503db813598b67b1e08f759758a1c2023396921fa
DrugSanguinarine [2447-54-3]; Down 200; 12uM; HL60; HT_HG-U133A

PDS5B INPP5B SPTBN1 CEP290 MED14 IPO9 HS2ST1 PDS5A PRKDC

6.12e-0718512092927_DN
DrugBenzonatate [104-31-4]; Up 200; 6.6uM; PC3; HT_HG-U133A

KMT2B VPS13C CEP290 MFSD9 ITPR2 FCF1 ZFYVE9 GNA12

9.64e-0619612081801_UP
DrugDiazoxide [364-98-7]; Down 200; 17.4uM; PC3; HT_HG-U133A

CUL4B PDS5B MID2 INPP5B POLE MFSD9 GIT2 MED22

1.00e-0519712082052_DN
Drug16, 16-dimethylprostaglandin E2 methyl acetate solution; Down 200; 10uM; PC3; HT_HG-U133A

HDAC9 ACADS RTEL1 INPP5B SPTBN1 MED14 MFSD9 GRAMD1C

1.04e-0519812086592_DN
DrugClopamide [636-54-4]; Up 200; 11.6uM; MCF7; HT_HG-U133A

ACADS INPP5B SPTBN1 CEP290 TLK1 TLR1 PDE5A GNAL

1.08e-0519912083220_UP
DiseaseGastric Adenocarcinoma

BRD3 ITK BRD2 ATM

2.79e-05451144C0278701
DiseaseMedulloblastoma

BRD3 BRD2 BRD4 ATM

4.24e-05501144C0025149
Diseasehypothyroidism

INPP5B FAM76B ITGB3 ITK LRRC8A P2RY10 GNA12

1.22e-042841147EFO_0004705
DiseaseWriter's Cramp

KMT2B GNAL

3.07e-0471142C4316810
DiseaseDystonia Disorders

KMT2B GNAL

3.07e-0471142C0393593
DiseaseIdiopathic familial dystonia

KMT2B GNAL

3.07e-0471142C0393598
DiseaseAdult-Onset Idiopathic Focal Dystonias

KMT2B GNAL

3.07e-0471142C0752198
DiseaseAdult-Onset Dystonias

KMT2B GNAL

3.07e-0471142C0752197
DiseaseAdult-Onset Idiopathic Torsion Dystonias

KMT2B GNAL

3.07e-0471142C0752199
DiseaseAutosomal Dominant Familial Dystonia

KMT2B GNAL

3.07e-0471142C0752200
DiseaseChildhood Onset Dystonias

KMT2B GNAL

3.07e-0471142C0752202
DiseaseAutosomal Recessive Familial Dystonia

KMT2B GNAL

3.07e-0471142C0752201
DiseaseDystonia, Primary

KMT2B GNAL

3.07e-0471142C0752203
DiseaseDystonias, Sporadic

KMT2B GNAL

3.07e-0471142C0752206
DiseaseDystonia, Secondary

KMT2B GNAL

3.07e-0471142C0752205
DiseasePseudodystonia

KMT2B GNAL

3.07e-0471142C0752208
DiseaseFamilial Dystonia

KMT2B GNAL

3.07e-0471142C0752207
DiseaseFocal Dystonia

KMT2B GNAL

3.07e-0471142C0743332
Diseasefemale breast cancer (is_implicated_in)

RTEL1 ATM

4.08e-0481142DOID:0050671 (is_implicated_in)
Diseaseanemia (phenotype), response to ribavirin

RASGRP3 DNAH17

5.23e-0491142EFO_0004272, GO_1901559
DiseaseCombined immunodeficiency

ITK MALT1 PRKDC

5.38e-04411143C0494261
DiseaseChildhood Medulloblastoma

BRD3 BRD2 BRD4

6.19e-04431143C0278510
DiseaseMelanotic medulloblastoma

BRD3 BRD2 BRD4

6.19e-04431143C1275668
DiseaseMedullomyoblastoma

BRD3 BRD2 BRD4

6.19e-04431143C0205833
DiseaseDesmoplastic Medulloblastoma

BRD3 BRD2 BRD4

6.19e-04431143C0751291
DiseaseAdult Medulloblastoma

BRD3 BRD2 BRD4

6.19e-04431143C0278876
DiseaseShort Stature, CTCAE

RSPH4A FBXL3

6.52e-04101142C2919142
DiseaseShort stature

RSPH4A FBXL3

6.52e-04101142C0349588
Diseasegastric adenocarcinoma (is_implicated_in)

RTEL1 ABCA13

7.95e-04111142DOID:3717 (is_implicated_in)
DiseasePrimary Ciliary Dyskinesia

OFD1 RSPH4A CCDC39

8.05e-04471143C4551720
Diseasemismatch repair cancer syndrome (is_implicated_in)

POLE ASTE1

9.52e-04121142DOID:0112182 (is_implicated_in)
DiseaseAlzheimer disease, Cognitive impairment

HDAC9 HNF4G

1.50e-03151142HP_0100543, MONDO_0004975
DiseaseIschemic stroke, tissue plasminogen activator measurement

HDAC9 PMF1

1.50e-03151142EFO_0004791, HP_0002140
DiseaseIschemic stroke, plasminogen activator inhibitor 1 measurement

HDAC9 PMF1

1.71e-03161142EFO_0004792, HP_0002140
DiseaseBenign neoplasm of stomach

POLE ATM

1.94e-03171142C0153943
DiseaseNeoplasm of uncertain or unknown behavior of stomach

POLE ATM

1.94e-03171142C0496905
DiseaseDystonia, Limb

KMT2B GNAL

1.94e-03171142C0751093
DiseaseDystonia, Diurnal

KMT2B GNAL

1.94e-03171142C0393610
DiseaseCarcinoma in situ of stomach

POLE ATM

1.94e-03171142C0154060
Diseasefactor XI measurement, Ischemic stroke

HDAC9 PMF1

1.94e-03171142EFO_0004694, HP_0002140
DiseaseDystonia, Paroxysmal

KMT2B GNAL

2.17e-03181142C0393588
Diseasefactor VIII measurement, Ischemic stroke

HDAC9 PMF1

2.42e-03191142EFO_0004630, HP_0002140
Diseasemyocardial infarction

HDAC9 NBEAL1 INPP5B IPO9 PLCB2 TBX20

2.43e-033501146EFO_0000612
Diseasecongenital heart disease (implicated_via_orthology)

KMT2B PLCB2 TBX20

2.44e-03691143DOID:1682 (implicated_via_orthology)
Diseaseneutrophil count

SPTBN1 PCDHA11 BRD3 CIT CREB5 ITPR2 MED22 ITSN2 GNA12 PLCB2 PRKDC TRAF3IP3 PMF1

2.65e-03138211413EFO_0004833
DiseaseFamilial aplasia of the vermis

OFD1 CEP290

2.69e-03201142cv:C0431399
DiseaseProstatic Neoplasms

ITSN1 ITGB3 BRD4 ITSN2 TMOD1 PDS5A PRKDC ATM

2.74e-036161148C0033578
DiseaseMalignant neoplasm of prostate

ITSN1 ITGB3 BRD4 ITSN2 TMOD1 PDS5A PRKDC ATM

2.74e-036161148C0376358
DiseaseStomach Carcinoma

POLE ATM

2.96e-03211142C0699791
Diseaseintellectual disability (implicated_via_orthology)

CUL4B ITSN1 ITSN2

3.10e-03751143DOID:1059 (implicated_via_orthology)
DiseaseBronchiectasis

RSPH4A CCDC39

3.25e-03221142C0006267
DiseaseGlioblastoma

BRD2 BRD4 SEPTIN14

3.59e-03791143C0017636
Diseasemean corpuscular hemoglobin concentration

CUL1 HDAC9 PDS5B SLC35D2 ITSN1 BRD3 OR10X1 ITPR2 BRD4 PRKDC TRAF3IP3

3.71e-03110511411EFO_0004528
Diseaselung squamous cell carcinoma (is_implicated_in)

POLE ATM

3.86e-03241142DOID:3907 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
NLMEVLKNAVKVVNF

FAM200B

341

P0CF97
AQALEKIFLQKVAQM

BRD3

126

Q15059
QLKSSLIMLQKTFDL

GRAMD1C

636

Q8IYS0
LIMLQKTFDLLNKNK

GRAMD1C

641

Q8IYS0
LKQEASFLKEQMILV

COG7

76

P83436
VFLRIKQQLLLISKM

COG7

586

P83436
KLQVIQFKLADMALA

ACADS

306

P16219
IVLMAEALEKLFLQK

BRD4

146

O60885
NMVIGILVFNKLVSK

ADGRB1

1106

O14514
LLSNFKTHLKMQIEV

ARFGEF1

511

Q9Y6D6
FQLKKQMLESVLLEL

GZF1

126

Q9H116
KILEILKLDQFLTLM

ABCA13

2306

Q86UQ4
ALVASEAKIQQLMKV

GIT2

436

Q14161
MATLNLFQIVSKHLK

CCDC42

261

Q96M95
MENAIKSVQIDLLKL

CAVIN4

61

Q5BKX8
ISQQTKLIDFLQAKM

CIT

1216

O14578
QMLLLETLKVKQTIL

ASTE1

441

Q2TB18
MNQKTILVLLILAVI

AOC3

1

Q16853
KQSLMTKINELNLFI

CCDC39

526

Q9UFE4
VELFKELSINVMKQL

GMCL1

246

Q96IK5
MASAKLNTLLQTKVI

NBEAL1

1591

Q6ZS30
KSLVATFIVKDLLMN

PDS5B

786

Q9NTI5
KVFFAVMLLQGIVQK

PGBD4

156

Q96DM1
KSVVANFIVKDLLMN

PDS5A

796

Q29RF7
EATNAVLMEQIKLLK

RGPD5

1676

Q99666
EATNAVLMEQIKLLK

RGPD8

1676

O14715
QQEFSIAMKLIKLKL

ITSN2

76

Q9NZM3
AKEKVFTMQDLLQLI

OFD1

101

O75665
VMDTKLKIIEILQFI

ITPR2

966

Q14571
LIVLNSLKKMANLTE

LRRC8A

581

Q8IWT6
SMLVQKLEDKISLLN

RELCH

356

Q9P260
VSMLKNEVAQLKQLL

CREB5

421

Q02930
LMENAAKETLVLKLN

PCDHA11

251

Q9Y5I1
QTMKINQTILKEFIL

OR10X1

16

Q8NGY0
IKELKLQTNHVTMLL

NEMF

396

O60524
LKLMQEKETGLNVFL

MALT1

446

Q9UDY8
QILKIAMVTIQLVLF

MCOLN3

66

Q8TDD5
AVLALVAIFIMSLNK

MFSD9

446

Q8NBP5
KVMENGLLFKELLQT

GPD1L

171

Q8N335
KEQIQINSAIEKFLM

LRRC53

601

A6NM62
MKLVSDLKQFLILND

MED22

76

Q15528
DDQVFLMKLQSLLAK

DYNC1LI1

371

Q9Y6G9
AILEKLMTLVSFKQN

FSIP2

826

Q5CZC0
VTDLKKAQINIVFDM

EFCAB9

56

A8MZ26
NENLSVLLMAKKFEI

ENOSF1

336

Q7L5Y1
VKKLDVLSNSLVINM

FBP2

71

O00757
ALLFMLNQKVKTLEV

PLVAP

156

Q9BX97
LKTKTIRQAMFQLLQ

OR51T1

296

Q8NGJ9
LKKIAATIISFMQVQ

PDE5A

351

O76074
LMIFKLVQARNKIIG

HRNR

76

Q86YZ3
KLLDTMVDTFLQKLV

PMF1

36

Q6P1K2
FVLISQLKEEVMSLK

FAM76B

246

Q5HYJ3
IILVNKLGQVFVKMA

KMT2B

2191

Q9UMN6
VLQKKLMAFTLQDLV

POLE

2206

Q07864
IQFVKLFGMVKIDNL

HNF4G

306

Q14541
IMEQLKSFQIIAHLK

IKBIP

106

Q70UQ0
NVMVKKQVFELLAAL

INF2

136

Q27J81
AVVLKSKMLFFLQLT

MED14

1356

O60244
MLVNQLAKDKTISVL

OR2T10

81

Q8NGZ9
LFLNKQDMLAEKVLA

GNAL

276

P38405
MNLLTAKDTKIILVI

KPNA2

426

P52292
QLTLMDAELFKKVVL

RGL4

226

Q8IZJ4
KLVVNLLQLSKMAIN

ATM

1646

Q13315
VFQASLKLLKMIITQ

CEP104

496

O60308
LAQVTFQVLSMKKEL

DNAH17

3731

Q9UFH2
MAIFKIAALQKVVDN

CEP290

941

O15078
INFSIKAKLDLVQSM

FCF1

76

Q9Y324
VLVANNSDTLKLLKM

FBXL3

191

Q9UKT7
IKMDILAQVLQILLK

CUL1

631

Q13616
VEFSIAMKLIKLKLQ

ITSN1

76

Q15811
LVQLAICKFEKTIML

IFIT1B

321

Q5T764
NAILMEQIKLLKSEI

GCC2

1586

Q8IWJ2
IILFLNKMDLLVEKV

GNA12

291

Q03113
IDLELFVNKMTATKL

INPP5B

736

P32019
KILKLIINELSNVME

IPO9

916

Q96P70
MTEKLSQKNINLIFA

ITGB3

321

P05106
QMSKELVELNKALAL

KIF4A

521

O95239
SLQKIIEIQSMSLKF

HDAC9

996

Q9UKV0
KELQVSLFQTLVLLM

CUL4B

741

Q13620
KNKAIIFMINLSVAD

P2RY10

66

O00398
VQNKKRQVAFFILLM

PCDHB6

6

Q9Y5E3
MNNFILLEEQLIKKS

ITK

1

Q08881
NLQRVTIKSMQLLFK

MROH2A

1286

A6NES4
AKLFMVAVKQELSQA

RTEL1

896

Q9NZ71
MLEITIQNAKAYLLK

RSPH4A

206

Q5TD94
AATIMILYVSKLNKI

SLC35D2

66

Q76EJ3
KMDFKTNILLKNLVT

TRIM43

61

Q96BQ3
FLTLKGSLKQRIQVM

SLC6A1

556

P30531
DLLTMKNLDSKVNII

SEPTIN14

176

Q6ZU15
ILKLLVQQFSILETM

TDO2

121

P48775
KLLQLKNFNTLMAVV

RASGRP3

231

Q8IV61
KLQLLAVVAFAVAML

HS2ST1

11

Q7LGA3
AMKKIEDNNTLVFIV

RPL23A

86

P62750
KQLQAIEFNKALLAM

SRP72

301

O76094
EILLTFKIKVMALNS

TBC1D7

241

Q9P0N9
MLALQIIDLFKNIFQ

PI4KAP2

346

A4QPH2
TLILQMNQLKELSKI

TLR1

376

Q15399
DLTSVNILLKKQQML

SPTBN1

1411

Q01082
MNTLFTLLKVDTQIK

ABCB7

441

O75027
AQTLEKIFLQKVASM

BRD2

166

P25440
LEKKMAVASILQSLQ

AFAP1L1

31

Q8TED9
ALLKVAQMVTLLIAF

CMTM7

46

Q96FZ5
MTKEFIGQQLILIIK

NCAPG

396

Q9BPX3
TIKISALKAIFDQLM

NCAPG

636

Q9BPX3
EVAMLLDTVQKVFQK

NCAPG2

946

Q86XI2
LLMELKVAAQKNFIL

C12orf56

351

Q8IXR9
LKQKMVILQDLLSTL

TRAF3IP3

211

Q9Y228
QLSFKIIQTDLTMLK

TLK1

206

Q9UKI8
LTMLKLAALESNKIQ

TLK1

216

Q9UKI8
KELQNFLSMFQKIIL

WASHC5

886

Q12768
EIVSMLEKNATLLKF

TMOD1

301

P28289
FKMLSNKESLDQIIV

UBL7

131

Q96S82
LELSSNKTFFIMLKI

TTMP

101

Q5BVD1
LQIMESQAEAFLKKL

TTC3

1656

P53804
LLNFEIKEVVVTLMK

VPS13C

1426

Q709C8
IIKEDVNSMQIFTKL

SUCO

806

Q9UBS9
TFLDKILVKLKMQLN

PLCB2

146

Q00722
TKMAVLALLAKILQI

PRKDC

1641

P78527
DFLHKMTVVVLQKLN

ZNF644

831

Q9H582
KMDFKTNILLKNLVT

TRIM43B

61

A6NCK2
LLKQMVSFEKVKLTN

TBX20

196

Q9UMR3
FEKLKQTLEMNLTNL

MID2

236

Q9UJV3
VFVLNANLLSMVKIV

ZFYVE9

941

O95405
KKFVQMLVFNLTLTE

UGT2A2

11

P0DTE5
QRVQKEQLAAIFKLM

MXRA7

166

P84157