Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-24	6.83e-12	37	54	7	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-24	8.36e-12	38	54	7	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7	3.04e-06	11	54	3	GO:0004523
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 TRIM9 ERVK-8 ERVK-19 ZFR ERVK-7 GATA5 ERVK-21 ERVK-9 ERVK-24 MARCHF4 TP53	3.51e-06	891	54	12	GO:0008270
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7	6.66e-06	14	54	3	GO:0003964
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 ERVK-7	2.40e-05	21	54	3	GO:0035613
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 TRIM9 ERVK-8 ERVK-19 ZFR ERVK-7 GATA5 ERVK-21 ERVK-9 ERVK-24 MARCHF4 TP53	6.26e-05	1189	54	12	GO:0046914
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 ATRX ERVK-8 ERCC6L2 ERVK-7 ARID1A	7.34e-05	262	54	6	GO:0140097
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7	1.36e-04	37	54	3	GO:0016891
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	ATRX ERCC6L2 ARID1A	1.36e-04	37	54	3	GO:0140658
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7	1.47e-04	38	54	3	GO:0034061
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-24	1.51e-04	430	54	7	GO:0004175
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7	2.61e-04	46	54	3	GO:0016893
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-24 USP21	3.49e-04	654	54	8	GO:0008233
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-8 ERVK-7 CNOT1	5.00e-04	136	54	4	GO:0004540
GeneOntologyMolecularFunction	structural molecule activity	ERVK-6 ERVK-8 LAMA5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 CTNND2 ERVK-24	5.88e-04	891	54	9	GO:0005198
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-8 ERVK-7	1.28e-03	79	54	3	GO:0004521
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ERVK-6 ATRX ERVK-8 ERCC6L2 ERVK-7 ARID1A CNOT1	1.68e-03	645	54	7	GO:0140640
GeneOntologyMolecularFunction	semaphorin receptor binding	SEMA4F SEMA7A	1.75e-03	23	54	2	GO:0030215
GeneOntologyMolecularFunction	chemorepellent activity	SEMA4F SEMA7A	2.78e-03	29	54	2	GO:0045499
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 ERVK-8 ERVK-7 CNOT1	3.51e-03	231	54	4	GO:0004518
GeneOntologyMolecularFunction	transcription coregulator activity	TCERG1 ZNF764 BCL3 PPP1R13L ARID1A USP21	3.98e-03	562	54	6	GO:0003712
GeneOntologyMolecularFunction	transcription factor binding	TCERG1 ASCL5 BCL3 PPP1R13L ARID1A CNOT1 TP53	4.00e-03	753	54	7	GO:0008134
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	TCERG1 ASCL5 BCL3 ARID1A CNOT1 TP53	4.71e-03	582	54	6	GO:0140297
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	ATRX ERCC6L2 ARID1A	4.92e-03	127	54	3	GO:0008094
GeneOntologyMolecularFunction	protein phosphatase 2A binding	SHC1 TP53	5.77e-03	42	54	2	GO:0051721
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-8 ERVK-7	5.95e-03	136	54	3	GO:0004519
GeneOntologyMolecularFunction	ATP-dependent activity	ATRX MYO1F ERCC6L2 KIFC3 ARID1A TP53	6.09e-03	614	54	6	GO:0140657
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	2.59e-06	85	53	5	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	2.59e-06	85	53	5	GO:0000768
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	ERVK-6 MIA3 PPP3CB ASCL5 ERVK-8 SHC1 ERVK-19 GATA5 ERVK-21 ERVK-9 BCL3 ARID1A CNOT1 AHDC1 TP53	3.04e-06	1483	53	15	GO:0048646
GeneOntologyBiologicalProcess	syncytium formation	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	3.25e-06	89	53	5	GO:0006949
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7	4.50e-06	13	53	3	GO:0015074
GeneOntologyBiologicalProcess	viral process	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-24 TP53	2.25e-05	464	53	8	GO:0016032
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-8 ERVK-7 TP53	6.14e-05	83	53	4	GO:0006278
GeneOntologyBiologicalProcess	DNA repair	ERVK-6 ATRX IFFO1 ERVK-8 ERCC6L2 ERVK-7 ARID1A TP53	2.31e-04	648	53	8	GO:0006281
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-8 ERVK-7	2.55e-04	48	53	3	GO:0000731
Domain	GATA_ZN_FINGER_1	ATRX GATA5	6.67e-04	16	45	2	PS00344
Domain	GATA_ZN_FINGER_2	ATRX GATA5	6.67e-04	16	45	2	PS50114
Domain	SH3_9	MYO1F PPP1R13L ARHGAP33	8.76e-04	78	45	3	PF14604
Domain	Semaphorin	SEMA4F SEMA7A	1.05e-03	20	45	2	IPR027231
Domain	SH3	MIA3 MYO1F PPP1R13L ARHGAP33	1.79e-03	216	45	4	SM00326
Domain	SH3	MIA3 MYO1F PPP1R13L ARHGAP33	1.79e-03	216	45	4	PS50002
Domain	SH2	SH3BP2 SHC1 LCP2	1.85e-03	101	45	3	PF00017
Domain	SH3_domain	MIA3 MYO1F PPP1R13L ARHGAP33	1.91e-03	220	45	4	IPR001452
Domain	SH2	SH3BP2 SHC1 LCP2	2.36e-03	110	45	3	SM00252
Domain	SH2	SH3BP2 SHC1 LCP2	2.42e-03	111	45	3	PS50001
Domain	SH2	SH3BP2 SHC1 LCP2	2.48e-03	112	45	3	IPR000980
Domain	-	SH3BP2 SHC1 LCP2	2.48e-03	112	45	3	3.30.505.10
Domain	Sema	SEMA4F SEMA7A	2.52e-03	31	45	2	SM00630
Domain	Semap_dom	SEMA4F SEMA7A	2.52e-03	31	45	2	IPR001627
Domain	Sema	SEMA4F SEMA7A	2.52e-03	31	45	2	PF01403
Domain	SEMA	SEMA4F SEMA7A	2.52e-03	31	45	2	PS51004
Domain	SNF2_N	ATRX ERCC6L2	2.69e-03	32	45	2	IPR000330
Domain	PSI	SEMA4F SEMA7A	2.69e-03	32	45	2	PF01437
Domain	SNF2_N	ATRX ERCC6L2	2.69e-03	32	45	2	PF00176
Domain	Plexin_repeat	SEMA4F SEMA7A	2.69e-03	32	45	2	IPR002165
Domain	-	PYGO2 ATRX TRIM9 MARCHF4 RNF215	4.35e-03	449	45	5	3.30.40.10
Domain	Znf_RING/FYVE/PHD	PYGO2 ATRX TRIM9 MARCHF4 RNF215	4.77e-03	459	45	5	IPR013083
Domain	SAM_2	DGKD LCP2	4.81e-03	43	45	2	PF07647
Domain	PSI	SEMA4F SEMA7A	5.04e-03	44	45	2	IPR016201
Domain	PSI	SEMA4F SEMA7A	5.49e-03	46	45	2	SM00423
Domain	SH3_1	MYO1F PPP1R13L ARHGAP33	7.20e-03	164	45	3	PF00018
Domain	Znf_RING	ATRX TRIM9 MARCHF4 RNF215	7.73e-03	326	45	4	IPR001841
Domain	Znf_C3HC4_RING-type	TRIM9 MARCHF4 RNF215	8.20e-03	172	45	3	IPR018957
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	5.86e-12	12	54	5	14557543
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-19 ERVK-7 ERVK-21	2.59e-11	5	54	4	12629516
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-24	1.34e-10	94	54	7	21542922
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-24	1.41e-08	4	54	3	10469592
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9	7.05e-08	6	54	3	15063128
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21	4.21e-07	10	54	3	12970426
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA4F ZNF48 SEMA7A TMC6 SHC1 LRP3 LAMA5 KIFC3 ARID1A AHDC1 ARHGAP33	8.67e-07	1105	54	11	35748872
Pubmed	p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses.	PPP1R13L TP53	2.37e-06	2	54	2	20840860
Pubmed	Genetic alterations analysis in prognostic stratified groups identified TP53 and ARID1A as poor clinical performance markers in intrahepatic cholangiocarcinoma.	ARID1A TP53	2.37e-06	2	54	2	29740198
Pubmed	iASPP is over-expressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway.	PPP1R13L TP53	2.37e-06	2	54	2	21192816
Pubmed	Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging.	SHC1 TP53	2.37e-06	2	54	2	23448364
Pubmed	iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.	PPP1R13L TP53	2.37e-06	2	54	2	31395738
Pubmed	Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling.	ATRX TP53	2.37e-06	2	54	2	29535300
Pubmed	Radiologic findings and the molecular expression profile of diffuse midline glioma H3 K27M mutant.	ATRX TP53	2.37e-06	2	54	2	33175579
Pubmed	The clinicopathologic significance of p53 and BAF-250a (ARID1A) expression in clear cell carcinoma of the endometrium.	ARID1A TP53	2.37e-06	2	54	2	23524907
Pubmed	p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.	SHC1 TP53	2.37e-06	2	54	2	22641095
Pubmed	Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms.	PPP1R13L TP53	2.37e-06	2	54	2	19263435
Pubmed	Expression of the Bcl-3 proto-oncogene suppresses p53 activation.	BCL3 TP53	2.37e-06	2	54	2	16384933
Pubmed	A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.	SHC1 TP53	2.37e-06	2	54	2	12032825
Pubmed	Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.	PPP1R13L TP53	2.37e-06	2	54	2	23623661
Pubmed	Inhibition of p53 and ATRX increases telomeric recombination in primary fibroblasts.	ATRX TP53	2.37e-06	2	54	2	37499040
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	2.37e-06	2	54	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	2.37e-06	2	54	2	9460924
Pubmed	iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.	PPP1R13L TP53	2.37e-06	2	54	2	16964264
Pubmed	The p53-p66Shc apoptotic pathway is dispensable for tumor suppression whereas the p66Shc-generated oxidative stress initiates tumorigenesis.	SHC1 TP53	2.37e-06	2	54	2	23092318
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-9 ERVK-24	2.84e-06	18	54	3	18664271
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF48 ZNF764 PBX4 ZFR BCL3 FBLIM1 ARID1A SF3B2 TP53	3.94e-06	808	54	9	20412781
Pubmed	Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer.	ARID1A TP53	7.09e-06	3	54	2	23702729
Pubmed	Wild-type and mutant p53 differentially modulate miR-124/iASPP feedback following pohotodynamic therapy in human colon cancer cell line.	PPP1R13L TP53	7.09e-06	3	54	2	29022915
Pubmed	A novel all-trans retinoic acid derivative 4-amino‑2‑trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP.	PPP1R13L TP53	7.09e-06	3	54	2	27177208
Pubmed	Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding.	ATRX TP53	7.09e-06	3	54	2	36073547
Pubmed	TP53 common variants and interaction with PPP1R13L and CD3EAP SNPs and lung cancer risk and smoking behavior in a Chinese population.	PPP1R13L TP53	7.09e-06	3	54	2	35351459
Pubmed	Insight into the structural basis of pro- and antiapoptotic p53 modulation by ASPP proteins.	PPP1R13L TP53	7.09e-06	3	54	2	19246451
Pubmed	p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination.	ATRX TP53	7.09e-06	3	54	2	12750285
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	7.09e-06	3	54	2	9971820
Pubmed	Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12.	ATRX TP53	7.09e-06	3	54	2	26891131
Pubmed	iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.	PPP1R13L TP53	7.09e-06	3	54	2	12524540
Pubmed	Treatments, prognostic factors, and genetic heterogeneity in advanced cholangiocarcinoma: A multicenter real-world study.	ARID1A TP53	7.09e-06	3	54	2	38457226
Pubmed	The ARID1A, p53 and ß-Catenin statuses are strong prognosticators in clear cell and endometrioid carcinoma of the ovary and the endometrium.	ARID1A TP53	7.09e-06	3	54	2	29451900
Pubmed	ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers.	ARID1A TP53	7.09e-06	3	54	2	21900401
Pubmed	Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability.	SHC1 TP53	7.09e-06	3	54	2	23832324
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-19	7.09e-06	3	54	2	10516026
Pubmed	DNA Methylation Profiles of Ovarian Clear Cell Carcinoma.	ARID1A TP53	7.09e-06	3	54	2	34697060
Pubmed	Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB.	PPP1R13L TP53	7.09e-06	3	54	2	26646590
Pubmed	ATRX loss in adult supratentorial diffuse astrocytomas correlates with p53 over expression and IDH1 mutation and predicts better outcome in p53 accumulated patients.	ATRX TP53	7.09e-06	3	54	2	26395639
Pubmed	Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability.	ARID1A TP53	7.09e-06	3	54	2	34987057
Pubmed	Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells.	PPP1R13L TP53	7.09e-06	3	54	2	29179704
Pubmed	Cancer gene mutation frequencies for the U.S. population.	ARID1A TP53	1.42e-05	4	54	2	34645806
Pubmed	Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-β (TGF-β).	SHC1 TP53	1.42e-05	4	54	2	22039050
Pubmed	Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer.	PPP1R13L TP53	1.42e-05	4	54	2	35717675
Pubmed	The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice.	ARID1A TP53	1.42e-05	4	54	2	27280691
Pubmed	Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation.	SEL1L TP53	1.42e-05	4	54	2	21903092
Pubmed	Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.	PPP1R13L TP53	1.42e-05	4	54	2	22011578
Pubmed	The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP.	PPP1R13L TP53	1.42e-05	4	54	2	17906639
Pubmed	Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis.	ARID1A TP53	1.42e-05	4	54	2	34941867
Pubmed	Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family.	SHC1 BCL3	1.42e-05	4	54	2	11707390
Pubmed	USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer.	TP53 USP21	1.42e-05	4	54	2	34531315
Pubmed	DNA ligase IV as a new molecular target for temozolomide.	ATRX TP53	1.42e-05	4	54	2	19615340
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-19	1.42e-05	4	54	2	7983737
Pubmed	Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.	ATRX TP53	1.42e-05	4	54	2	17296936
Pubmed	Differential regulation of TCR-mediated gene transcription by Vav family members.	SH3BP2 LCP2	1.42e-05	4	54	2	14757747
Pubmed	Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapy.	ARID1A TP53	1.42e-05	4	54	2	33822841
Pubmed	Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.	PYGO2 TSBP1 SHC1 LAMA5 GATA5	1.54e-05	201	54	5	23535732
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	TRIM9 MYO1F CTNND2 PPP1R13L ARHGAP33	2.28e-05	218	54	5	33378226
Pubmed	p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1.	BCL3 TP53	2.36e-05	5	54	2	12808109
Pubmed	Structural and biochemical characterization of DAXX-ATRX interaction.	ATRX TP53	2.36e-05	5	54	2	28875283
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	2.36e-05	5	54	2	11401426
Pubmed	SLP-76-Cbl-Grb2-Shc interactions in FcgammaRI signaling.	SHC1 LCP2	2.36e-05	5	54	2	9716598
Pubmed	The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53.	PPP1R13L TP53	2.36e-05	5	54	2	21513714
Pubmed	Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer.	ARID1A TP53	2.36e-05	5	54	2	27520487
Pubmed	High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias.	ARID1A TP53	2.36e-05	5	54	2	24241536
Pubmed	Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73.	PPP1R13L TP53	2.36e-05	5	54	2	18275817
Pubmed	Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss.	ATRX TP53	2.36e-05	5	54	2	29026176
Pubmed	Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma.	ARID1A TP53	2.36e-05	5	54	2	36044839
Pubmed	Altered PTEN, ATRX, CHGA, CHGB, and TP53 expression are associated with aggressive VHL-associated pancreatic neuroendocrine tumors.	ATRX TP53	2.36e-05	5	54	2	23361940
Pubmed	Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.	PPP1R13L TP53	2.36e-05	5	54	2	15558054
Pubmed	Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma.	ARID1A TP53	2.36e-05	5	54	2	28202515
Pubmed	Increases of iASPP-Keap1 interaction mediated by syringin enhance synaptic plasticity and rescue cognitive impairments via stabilizing Nrf2 in Alzheimer's models.	PPP1R13L TP53	2.36e-05	5	54	2	32828017
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	RBM12 ATRX ZFR ARID1A SF3B2	2.38e-05	220	54	5	35785414
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	ATRX TRIM9 LAMA5 DGKD PPP1R13L SF3B2 TP53	2.49e-05	560	54	7	21653829
Pubmed	Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint.	LCP2 TP53	3.54e-05	6	54	2	16456545
Pubmed	Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling.	SHC1 LCP2	3.54e-05	6	54	2	10477741
Pubmed	Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus.	ATRX TP53	3.54e-05	6	54	2	37200088
Pubmed	ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice.	ARID1A TP53	3.54e-05	6	54	2	29604291
Pubmed	Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer.	PYGO2 TP53	3.54e-05	6	54	2	36897957
Pubmed	The tumour suppressor CYLD regulates the p53 DNA damage response.	TP53 USP21	4.94e-05	7	54	2	27561390
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	MIA3 TCERG1 TRIM9 ARID1A CNOT1	5.56e-05	263	54	5	34702444
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	RBM12 PYGO2 ZFR ARID1A CNOT1 AHDC1	7.55e-05	457	54	6	32344865
Pubmed	Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.	TCERG1 ARID1A SF3B2	9.76e-05	57	54	3	38223760
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	TCERG1 ARID1A WIPF2 SF3B2	9.84e-05	154	54	4	16055720
Pubmed	Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.	ARID1A CNOT1 TP53	1.08e-04	59	54	3	28813667
Pubmed	Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase.	MAGEL2 TP53	1.29e-04	11	54	2	24911587
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	TCERG1 TRIM9 ZFR ARID1A WIPF2 SF3B2	1.32e-04	506	54	6	30890647
Pubmed	Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.	SH3BP2 SHC1 LCP2	2.39e-04	77	54	3	22973453
Pubmed	Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.	SHC1 LCP2	2.45e-04	15	54	2	10790433
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	SHC1 ARID1A TP53	2.57e-04	79	54	3	26446488
Pubmed	Histone H3.3 maintains genome integrity during mammalian development.	ATRX TP53	2.80e-04	16	54	2	26159997
Pubmed	A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis.	SEMA4F RGS11 CTNND2	2.87e-04	82	54	3	30728831
Pubmed	Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.	ERCC6L2 ARHGAP33	3.17e-04	17	54	2	20873783
Pubmed	Human transcription factor protein interaction networks.	RBM12 PYGO2 ATRX TCERG1 TRIM9 ZFR ARID1A CNOT1 TP53	3.26e-04	1429	54	9	35140242
Interaction	EVL interactions	TCERG1 TRIM9 FBLIM1 WIPF2 TP53	1.73e-06	83	49	5	int:EVL
Interaction	TOP3B interactions	SEMA4F ZNF48 SEMA7A TMC6 SHC1 LRP3 LAMA5 ZFR KIFC3 ARID1A CNOT1 AHDC1 TP53 ARHGAP33	6.76e-06	1470	49	14	int:TOP3B
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA4F SEMA7A	6.77e-04	20	35	2	736
GeneFamily	SH2 domain containing	SH3BP2 SHC1 LCP2	9.73e-04	101	35	3	741
Disease	Aortic valve calcification	GATA5 TP53	5.41e-05	7	48	2	C0428791
Disease	endometrial adenocarcinoma (is_implicated_in)	ARID1A TP53	5.41e-05	7	48	2	DOID:2870 (is_implicated_in)
Disease	very low density lipoprotein cholesterol measurement	MYO1F PBX4 BCL3 SIK3 ARID1A	6.42e-05	260	48	5	EFO_0008317
Disease	cholesteryl esters to total lipids in IDL percentage	BCL3 SIK3 ARID1A	7.50e-05	50	48	3	EFO_0022247
Disease	level of Ceramide (d40:1) in blood serum	PBX4 SIK3	1.41e-04	11	48	2	OBA_2045185
Disease	Adenocarcinoma Of Esophagus	ARID1A TP53	2.33e-04	14	48	2	C0279628
Disease	T-Cell Lymphoma	ARID1A TP53	3.06e-04	16	48	2	C0079772
Disease	very low density lipoprotein cholesterol measurement, phospholipid measurement	RBM12 PBX4 SIK3 ARID1A	5.26e-04	229	48	4	EFO_0004639, EFO_0008317
Disease	Adenoid Cystic Carcinoma	ATRX ARID1A TP53	5.85e-04	100	48	3	C0010606
Disease	Granulomatous Slack Skin	ARID1A TP53	5.86e-04	22	48	2	C0376407
Disease	Nasopharyngeal carcinoma	ARID1A TP53	5.86e-04	22	48	2	C2931822
Disease	Lymphoma, T-Cell, Cutaneous	ARID1A TP53	6.41e-04	23	48	2	C0079773
Disease	apolipoprotein B measurement	PBX4 BCL3 SIK3 PPP1R13L ARID1A TP53	6.92e-04	663	48	6	EFO_0004615
Disease	familial hyperlipidemia	PBX4 BCL3 ARID1A	6.93e-04	106	48	3	MONDO_0001336
Disease	Intrahepatic Cholangiocarcinoma	ARID1A TP53	6.99e-04	24	48	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	ARID1A TP53	6.99e-04	24	48	2	C3805278
Disease	bilirubin measurement	TMC6 PBX4 DGKD BCL3 ARID1A	7.43e-04	442	48	5	EFO_0004570
Disease	Cholangiocarcinoma	ARID1A TP53	8.21e-04	26	48	2	C0206698
Disease	Sezary Syndrome	ARID1A TP53	8.86e-04	27	48	2	C0036920
Disease	Bilateral Wilms Tumor	ARID1A TP53	1.02e-03	29	48	2	C2930471
Disease	Hematopoetic Myelodysplasia	ATRX TP53	1.02e-03	29	48	2	C2713368
Disease	Nephroblastoma	ARID1A TP53	1.58e-03	36	48	2	C0027708
Disease	Burkitt Lymphoma	ARID1A TP53	1.58e-03	36	48	2	C0006413
Disease	triacylglycerol 52:4 measurement	SIK3 CNOT1	1.58e-03	36	48	2	EFO_0010416

Protein segments in the cluster

Peptide	Gene	Start	Entry
GVMPPPRQAPLPPAE	ASCL5	96	Q7RTU5
AAMPGLFVPPVAPRP	SH3BP2	371	P78314
MARPPGPPRGPAAAA	AHDC1	1521	Q5TGY3
PPGAAPLGAMPVPDQ	CTNND2	6	Q9UQB3
PLNPPPVAPLPAGMN	RBM12	246	Q9NTZ6
MAAGPAPPPGRPRAQ	RGS11	1	O94810
PAAVPGNQMPPRPPS	ARID1A	716	O14497
MPPAGGPRAPRPAAL	FAM189A1	1	O60320
QPAAPGAPMVQPPPA	MAGEL2	251	Q9UJ55
PPASGAPMAQPAAPP	MAGEL2	301	Q9UJ55
PAAPPAQPMAPPAQP	MAGEL2	311	Q9UJ55
QPAPGAAPDPPAPLM	LRP3	641	O75074
MPEAAPPVAPAPAAP	TP53	66	P04637
PAMSPAGPRPRPPTA	LAMA5	1256	O15230
YSPPGPGPAPPAAMA	IFFO1	51	Q0D2I5
FPPNPMGPAFNMPPQ	PYGO2	136	Q9BRQ0
MAAPPRPAPSPPAPR	PBX4	1	Q9BYU1
GGAPPPPPKNPARLM	ARHGAP33	886	O14559
PGMPPAPQGRAPYPQ	ERVK-19	231	Q9YNA8
PGMPPAPQGRAPYPQ	ERVK-21	231	P62683
PGMPPAPQGRAPYPQ	ERVK-24	231	P63145
PGMPPAPQGRAPYPQ	ERVK-6	231	Q7LDI9
PGMPPAPQGRAPYPQ	ERVK-7	231	P63130
PGMPPAPQGREPYPQ	ERVK-8	231	P62685
PGMPPAPQGRAPYPQ	ERVK-9	231	P63126
PGAGSPMFVPPARVP	GATA5	26	Q9BWX5
PGMPPAPQGRAPYPQ	HERVK_113	231	P62684
GMQPPPLQRAPPPMR	ATRX	2466	P46100
GMSPAPNGAKVPPRP	C4orf17	96	Q53FE4
RPPQAPLPMHGDPQP	MARCHF4	56	Q9P2E8
MAAAAGAPPPGPPQP	DGKD	1	Q16760
APMQLFNGGCPPPPP	FBLIM1	76	Q8WUP2
APPPGRMDPSAPQPR	ERCC6L2	6	Q5T890
SPPRDPPGFPMAPPN	BCL3	406	P20749
MAAPEPARAAPPPPP	PPP3CB	1	P16298
RIPMPPSSPQPRGAP	PPP1R13L	351	Q8WUF5
MPPPPAPAPGAQAAR	PRR18	6	Q8N4B5
MPASAARPRPGPGQP	SEMA4F	1	O95754
HQDMPAPRPPGPRPA	SEL1L	766	Q9UBV2
NMAPKGPPPFPGVPL	MIA3	1756	Q5JRA6
PEPEPGMARPAPAPA	KIFC3	26	Q9BVG8
MGPAARPALRSPPPP	RNF215	1	Q9Y6U7
GQPRPPAPASRGPMP	SIK3	46	Q9Y2K2
PGMPPAPQGRAPYPQ	ERVK-9	231	P63128
QPPPGVMPKGRPPSA	CNOT1	686	A5YKK6
PRGPPPPPGDENREM	SF3B2	246	Q13435
RPHNPPGPVPMAPRP	ZNF48	516	Q96MX3
PASGPNPMLRPLPPR	USP21	41	Q9UK80
PGVPPPPAMGVPRDR	nan	46	Q6ZSN1
GPAPPPNAVMRGPPP	TCERG1	31	O14776
PNAVMRGPPPLMRPP	TCERG1	36	O14776
MTPPPPGRAAPSAPR	SEMA7A	1	O75326
PNGVRVFPPAMPPPA	TRIM9	96	Q9C026
MPPQPQGPAPLRRPD	ZFR	706	Q96KR1
MGPQVAFPPALPGPA	TMC6	271	Q7Z403
PPGRRANAPPTPLPM	WIPF2	181	Q8TF74
NAGPPSAPRGPPMAP	TSBP1	171	Q5SRN2
GGDPEVRKQMPPPPP	SHC1	401	P29353
MAPPLAPLPPRDPNG	ZNF764	1	Q96H86
QRPMAALPPPPAGRN	LCP2	191	Q13094
APAPPRGMDRNGVPP	MYO1F	946	O00160