Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	bone sialoprotein binding	ANXA2 ANXA2P2	1.59e-05	2	80	2	GO:0044730
GeneOntologyMolecularFunction	glutamate receptor binding	CDK5R1 GRIP2 PLCG1 GRIN2A GNAS	1.84e-05	81	80	5	GO:0035254
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCG4 ABCA1 ABCA12 ATP13A1	4.41e-05	49	80	4	GO:0140359
GeneOntologyMolecularFunction	phospholipase A2 inhibitor activity	ANXA2 ANXA2P2	1.57e-04	5	80	2	GO:0019834
GeneOntologyMolecularFunction	ATPase-coupled lipid transmembrane transporter activity	ABCG4 ABCA12	5.60e-04	9	80	2	GO:0034040
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	PDE1B PLCG1 GNAS TDP2	6.24e-04	97	80	4	GO:0008081
GeneOntologyBiologicalProcess	positive regulation of sterol transport	ABCG4 ABCA1 ABCA12 ANXA2 ANXA2P2	4.87e-07	40	81	5	GO:0032373
GeneOntologyBiologicalProcess	positive regulation of cholesterol transport	ABCG4 ABCA1 ABCA12 ANXA2 ANXA2P2	4.87e-07	40	81	5	GO:0032376
GeneOntologyBiologicalProcess	positive regulation of intracellular lipid transport	ABCA12 ANXA2 ANXA2P2	5.80e-07	5	81	3	GO:0032379
GeneOntologyBiologicalProcess	indole-containing compound metabolic process	AANAT PDE1B GCDH GRIN2A	6.41e-06	31	81	4	GO:0042430
GeneOntologyBiologicalProcess	localization within membrane	CDK5R1 ABCA12 ATP13A1 ANXA2 ANXA2P2 RAB3GAP2 NBEA SPG11 GRIP2 GRIN2A INPP5F AP3B1 HECTD1	1.30e-05	798	81	13	GO:0051668
GeneOntologyBiologicalProcess	cholesterol transport	ABCG4 ABCA1 ABCA12 ANXA2 ANXA2P2 SPG11	1.46e-05	134	81	6	GO:0030301
GeneOntologyBiologicalProcess	positive regulation of low-density lipoprotein particle receptor binding	ANXA2 ANXA2P2	1.52e-05	2	81	2	GO:1905597
GeneOntologyBiologicalProcess	regulation of intracellular lipid transport	ABCA12 ANXA2 ANXA2P2	1.62e-05	13	81	3	GO:0032377
GeneOntologyBiologicalProcess	receptor metabolic process	ANXA2 ANXA2P2 CAPN1 GRIN2A INPP5F	1.77e-05	82	81	5	GO:0043112
GeneOntologyBiologicalProcess	sterol transport	ABCG4 ABCA1 ABCA12 ANXA2 ANXA2P2 SPG11	1.80e-05	139	81	6	GO:0015918
GeneOntologyBiologicalProcess	regulation of cholesterol transport	ABCG4 ABCA1 ABCA12 ANXA2 ANXA2P2	1.88e-05	83	81	5	GO:0032374
GeneOntologyBiologicalProcess	regulation of sterol transport	ABCG4 ABCA1 ABCA12 ANXA2 ANXA2P2	1.88e-05	83	81	5	GO:0032371
GeneOntologyBiologicalProcess	positive regulation of receptor-mediated endocytosis involved in cholesterol transport	ANXA2 ANXA2P2	4.56e-05	3	81	2	GO:1905602
GeneOntologyBiologicalProcess	negative regulation of low-density lipoprotein particle receptor catabolic process	ANXA2 ANXA2P2	4.56e-05	3	81	2	GO:0032804
GeneOntologyBiologicalProcess	positive regulation of receptor recycling	ANXA2 ANXA2P2 INPP5F	4.56e-05	18	81	3	GO:0001921
GeneOntologyBiologicalProcess	positive regulation of lipid transport	ABCG4 ABCA1 ABCA12 ANXA2 ANXA2P2	5.10e-05	102	81	5	GO:0032370
GeneOntologyBiologicalProcess	intracellular lipid transport	ABCA1 ABCA12 ANXA2 ANXA2P2	5.58e-05	53	81	4	GO:0032365
GeneOntologyBiologicalProcess	receptor recycling	ANXA2 ANXA2P2 GRIN2A INPP5F	6.46e-05	55	81	4	GO:0001881
GeneOntologyBiologicalProcess	phosphatidylinositol catabolic process	PLCG1 INPP5F	9.09e-05	4	81	2	GO:0031161
GeneOntologyBiologicalProcess	positive regulation of low-density lipoprotein particle clearance	ANXA2 ANXA2P2	9.09e-05	4	81	2	GO:1905581
GeneOntologyBiologicalProcess	negative regulation of receptor catabolic process	ANXA2 ANXA2P2	9.09e-05	4	81	2	GO:2000645
GeneOntologyBiologicalProcess	cellular response to high density lipoprotein particle stimulus	ABCG4 ABCA1	9.09e-05	4	81	2	GO:0071403
GeneOntologyBiologicalProcess	positive regulation of intracellular cholesterol transport	ANXA2 ANXA2P2	9.09e-05	4	81	2	GO:0032385
GeneOntologyBiologicalProcess	positive regulation of intracellular sterol transport	ANXA2 ANXA2P2	9.09e-05	4	81	2	GO:0032382
GeneOntologyBiologicalProcess	protein localization to membrane	CDK5R1 ABCA12 ATP13A1 ANXA2 ANXA2P2 RAB3GAP2 NBEA GRIP2 GRIN2A AP3B1 HECTD1	9.46e-05	705	81	11	GO:0072657
GeneOntologyBiologicalProcess	regulation of ARF protein signal transduction	PSD2 PSD GRIN2A	9.76e-05	23	81	3	GO:0032012
GeneOntologyBiologicalProcess	primary amino compound metabolic process	PDE1B AZIN2 GRIN2A	9.76e-05	23	81	3	GO:1901160
GeneOntologyBiologicalProcess	ARF protein signal transduction	PSD2 PSD GRIN2A	1.11e-04	24	81	3	GO:0032011
GeneOntologyBiologicalProcess	biogenic amine metabolic process	AANAT PDE1B AZIN2 GCDH GRIN2A	1.15e-04	121	81	5	GO:0006576
GeneOntologyBiologicalProcess	positive regulation of plasma membrane repair	ANXA2 ANXA2P2	1.51e-04	5	81	2	GO:1905686
GeneOntologyBiologicalProcess	regulation of low-density lipoprotein particle receptor binding	ANXA2 ANXA2P2	1.51e-04	5	81	2	GO:1905595
GeneOntologyBiologicalProcess	positive regulation of lipid localization	ABCG4 ABCA1 ABCA12 ANXA2 ANXA2P2	1.55e-04	129	81	5	GO:1905954
GeneOntologyBiologicalProcess	positive regulation of cholesterol efflux	ABCG4 ABCA1 ABCA12	1.59e-04	27	81	3	GO:0010875
GeneOntologyBiologicalProcess	positive regulation of low-density lipoprotein receptor activity	ANXA2 ANXA2P2	2.26e-04	6	81	2	GO:1905599
GeneOntologyBiologicalProcess	cholesterol efflux	ABCG4 ABCA1 ABCA12 SPG11	2.40e-04	77	81	4	GO:0033344
GeneOntologyBiologicalProcess	regulation of receptor recycling	ANXA2 ANXA2P2 INPP5F	2.42e-04	31	81	3	GO:0001919
GeneOntologyBiologicalProcess	receptor catabolic process	ANXA2 ANXA2P2 CAPN1	2.42e-04	31	81	3	GO:0032801
GeneOntologyBiologicalProcess	protein localization to cell surface	ABCA12 ASTN2 USP4 AP3B1	2.65e-04	79	81	4	GO:0034394
GeneOntologyBiologicalProcess	amine metabolic process	AANAT PDE1B AZIN2 GCDH GRIN2A	2.94e-04	148	81	5	GO:0009308
GeneOntologyBiologicalProcess	regulation of low-density lipoprotein particle receptor catabolic process	ANXA2 ANXA2P2	3.16e-04	7	81	2	GO:0032803
GeneOntologyBiologicalProcess	low-density lipoprotein particle receptor catabolic process	ANXA2 ANXA2P2	3.16e-04	7	81	2	GO:0032802
GeneOntologyBiologicalProcess	low-density lipoprotein receptor particle metabolic process	ANXA2 ANXA2P2	3.16e-04	7	81	2	GO:0032799
GeneOntologyBiologicalProcess	cellular catabolic process	PHKA1 CDK5R1 AASS ANXA2 ANXA2P2 RAB3GAP2 CAPN1 AMDHD2 CHEK2 GCDH SPG11 PLCG1 INPP5F FBXL4	3.43e-04	1253	81	14	GO:0044248
GeneOntologyBiologicalProcess	intracellular cholesterol transport	ABCA1 ANXA2 ANXA2P2	3.79e-04	36	81	3	GO:0032367
GeneOntologyBiologicalProcess	regulation of receptor-mediated endocytosis involved in cholesterol transport	ANXA2 ANXA2P2	4.20e-04	8	81	2	GO:1905600
GeneOntologyBiologicalProcess	regulation of plasma membrane repair	ANXA2 ANXA2P2	4.20e-04	8	81	2	GO:1905684
GeneOntologyBiologicalProcess	positive regulation of receptor binding	ANXA2 ANXA2P2	4.20e-04	8	81	2	GO:1900122
GeneOntologyBiologicalProcess	vacuole organization	ABCA1 ANXA2 RAB3GAP2 CHEK2 SPG11 AP3B1	4.44e-04	249	81	6	GO:0007033
GeneOntologyBiologicalProcess	intracellular sterol transport	ABCA1 ANXA2 ANXA2P2	4.82e-04	39	81	3	GO:0032366
GeneOntologyBiologicalProcess	regulation of lipid transport	ABCG4 ABCA1 ABCA12 ANXA2 ANXA2P2	7.00e-04	179	81	5	GO:0032368
GeneOntologyBiologicalProcess	receptor-mediated endocytosis involved in cholesterol transport	ANXA2 ANXA2P2	8.19e-04	11	81	2	GO:0090118
GeneOntologyBiologicalProcess	positive regulation of lipoprotein particle clearance	ANXA2 ANXA2P2	9.80e-04	12	81	2	GO:0010986
GeneOntologyBiologicalProcess	regulation of intracellular sterol transport	ANXA2 ANXA2P2	9.80e-04	12	81	2	GO:0032380
GeneOntologyBiologicalProcess	regulation of intracellular cholesterol transport	ANXA2 ANXA2P2	9.80e-04	12	81	2	GO:0032383
GeneOntologyBiologicalProcess	mRNA transcription by RNA polymerase II	ANXA2 ANXA2P2 AP3B1	1.12e-03	52	81	3	GO:0042789
GeneOntologyBiologicalProcess	regulation of catabolic process	PHKA1 CDK5R1 TBRG4 AZIN2 ANXA2 ANXA2P2 RAB3GAP2 SAMD4B CAPN1 CHEK2 GRIN2A HECTD1 SAMD4A	1.13e-03	1252	81	13	GO:0009894
GeneOntologyBiologicalProcess	adenylate cyclase-activating dopamine receptor signaling pathway	TAAR1 GNAS	1.16e-03	13	81	2	GO:0007191
GeneOntologyCellularComponent	pinosome	CARMIL2 ANXA2 ANXA2P2	9.38e-06	11	82	3	GO:0044352
GeneOntologyCellularComponent	macropinosome	CARMIL2 ANXA2 ANXA2P2	9.38e-06	11	82	3	GO:0044354
GeneOntologyCellularComponent	ruffle	PSD2 CARMIL2 PSD ANXA2 ANXA2P2 PLCG1 GNAS	1.66e-05	206	82	7	GO:0001726
GeneOntologyCellularComponent	AnxA2-p11 complex	ANXA2 ANXA2P2	4.55e-05	3	82	2	GO:1990665
GeneOntologyCellularComponent	PCSK9-AnxA2 complex	ANXA2 ANXA2P2	4.55e-05	3	82	2	GO:1990667
GeneOntologyCellularComponent	dendrite	CDK5R1 PSD2 PSD SACS AZIN2 KCNJ12 SPG11 GRIP2 GRIN2A GNAS INPP5F SAMD4A	1.25e-04	858	82	12	GO:0030425
GeneOntologyCellularComponent	dendritic tree	CDK5R1 PSD2 PSD SACS AZIN2 KCNJ12 SPG11 GRIP2 GRIN2A GNAS INPP5F SAMD4A	1.27e-04	860	82	12	GO:0097447
GeneOntologyCellularComponent	somatodendritic compartment	CDK5R1 PSD2 PSD PDE1B SACS AZIN2 KCNJ12 ASTN2 SPG11 GRIP2 GRIN2A GNAS INPP5F SAMD4A	2.78e-04	1228	82	14	GO:0036477
GeneOntologyCellularComponent	myelin sheath adaxonal region	ANXA2 ANXA2P2	3.15e-04	7	82	2	GO:0035749
GeneOntologyCellularComponent	clathrin-coated vesicle	CLTCL1 ASTN2 PLCG1 INPP5F HEATR5B AP3B1	3.40e-04	237	82	6	GO:0030136
GeneOntologyCellularComponent	coated vesicle	CLTCL1 ASTN2 PLCG1 GNAS INPP5F HEATR5B AP3B1	5.32e-04	360	82	7	GO:0030135
GeneOntologyCellularComponent	cell leading edge	PSD2 CARMIL2 PSD ANXA2 ANXA2P2 PLCG1 GRIN2A GNAS	7.67e-04	500	82	8	GO:0031252
GeneOntologyCellularComponent	postsynaptic density, intracellular component	PSD GRIP2 GRIN2A	9.41e-04	49	82	3	GO:0099092
GeneOntologyCellularComponent	postsynaptic specialization, intracellular component	PSD GRIP2 GRIN2A	1.39e-03	56	82	3	GO:0099091
GeneOntologyCellularComponent	Schmidt-Lanterman incisure	ANXA2 ANXA2P2	1.99e-03	17	82	2	GO:0043220
GeneOntologyCellularComponent	cornified envelope	ANXA2 ANXA2P2 CAPN1	2.53e-03	69	82	3	GO:0001533
GeneOntologyCellularComponent	compact myelin	ANXA2 ANXA2P2	3.04e-03	21	82	2	GO:0043218
Domain	-	SAMD4B SAMD4A	1.81e-05	2	80	2	1.25.40.170
Domain	PHAT_dom	SAMD4B SAMD4A	1.81e-05	2	80	2	IPR015327
Domain	ARM-type_fold	STK36 CLTCL1 CIP2A NBEA HEATR5B AP3B1 HECTD1	6.23e-04	339	80	7	IPR016024
Domain	PH_dom-spectrin-type	PSD2 PSD	6.40e-04	9	80	2	IPR001605
Domain	ABC_transporter_CS	ABCG4 ABCA1 ABCA12	7.70e-04	42	80	3	IPR017871
Domain	MACPF	ASTN2 C9	9.72e-04	11	80	2	PF01823
Domain	ARM-like	STK36 CIP2A NBEA HEATR5B AP3B1 HECTD1	1.06e-03	270	80	6	IPR011989
Domain	ABC_tran	ABCG4 ABCA1 ABCA12	1.14e-03	48	80	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCG4 ABCA1 ABCA12	1.14e-03	48	80	3	PS50893
Domain	MACPF	ASTN2 C9	1.16e-03	12	80	2	SM00457
Domain	ABC_A	ABCA1 ABCA12	1.16e-03	12	80	2	IPR026082
Domain	MACPF	ASTN2 C9	1.16e-03	12	80	2	IPR020864
Domain	ABC_TRANSPORTER_1	ABCG4 ABCA1 ABCA12	1.21e-03	49	80	3	PS00211
Domain	ABC_transporter-like	ABCG4 ABCA1 ABCA12	1.28e-03	50	80	3	IPR003439
Domain	-	PSD2 PSD	1.83e-03	15	80	2	1.10.1000.11
Domain	Sec7	PSD2 PSD	1.83e-03	15	80	2	PF01369
Domain	Sec7_alpha_orthog	PSD2 PSD	1.83e-03	15	80	2	IPR023394
Domain	Sec7	PSD2 PSD	2.09e-03	16	80	2	SM00222
Domain	SEC7	PSD2 PSD	2.09e-03	16	80	2	PS50190
Domain	Sec7_dom	PSD2 PSD	2.09e-03	16	80	2	IPR000904
Domain	-	STK36 CIP2A HEATR5B AP3B1 HECTD1	2.65e-03	222	80	5	1.25.10.10
Domain	AAA+_ATPase	ABCG4 ABCA1 ABCA12 ATAD2B	3.41e-03	144	80	4	IPR003593
Domain	AAA	ABCG4 ABCA1 ABCA12 ATAD2B	3.41e-03	144	80	4	SM00382
Domain	Acetyltransf_1	AANAT NAT10	4.32e-03	23	80	2	PF00583
Domain	GNAT	AANAT NAT10	5.10e-03	25	80	2	PS51186
Domain	GNAT_dom	AANAT NAT10	5.10e-03	25	80	2	IPR000182
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	STK36 SACS ADAMTS9 ATP13A1 CIP2A NELFB ASTN2 ADGRF5 HECTD1 SEMA4C	2.57e-07	493	82	10	15368895
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	SACS ANXA2 CIP2A RAB3GAP2 NAT10 NBEA PLCG1 INPP5F AP3B1	2.73e-06	498	82	9	36634849
Pubmed	A competitive hexapeptide inhibitor of annexin A2 prevents hypoxia-induced angiogenic events.	ANXA2 ANXA2P2	5.49e-06	2	82	2	21486955
Pubmed	Deletion of 2-aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1.	AASS GCDH	5.49e-06	2	82	2	32567100
Pubmed	Lipid raft endocytosis and exosomal transport facilitate extracellular trafficking of annexin A2.	ANXA2 ANXA2P2	5.49e-06	2	82	2	21737841
Pubmed	Vascular endothelial growth factor upregulates expression of annexin A2 in vitro and in a mouse model of ischemic retinopathy.	ANXA2 ANXA2P2	5.49e-06	2	82	2	19536308
Pubmed	NR4A3 and CCL20 clusters dominate the genetic networks in CD146+ blood cells during acute myocardial infarction in humans.	NR4A3 CCL20	5.49e-06	2	82	2	34565470
Pubmed	G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency.	STK36 GNAS	5.49e-06	2	82	2	19158402
Pubmed	Annexin A2 modulates radiation-sensitive transcriptional programming and cell fate.	ANXA2 ANXA2P2	5.49e-06	2	82	2	23148505
Pubmed	Regulation of the low-dose radiation paracrine-specific anchorage-independent growth response by annexin A2.	ANXA2 ANXA2P2	5.49e-06	2	82	2	19580511
Pubmed	The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages.	ABCA1 HECTD1	5.49e-06	2	82	2	29306077
Pubmed	ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells.	ANXA2 ANXA2P2	5.49e-06	2	82	2	38290972
Pubmed	The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats.	ANXA2 ANXA2P2	5.49e-06	2	82	2	3013423
Pubmed	Activation of Annexin A2 signaling at the blood-brain barrier in a mouse model of multiple sclerosis.	ANXA2 ANXA2P2	5.49e-06	2	82	2	35064931
Pubmed	Complex Roles of Annexin A2 in Host Blood-Brain Barrier Invasion by Cryptococcus neoformans.	ANXA2 ANXA2P2	5.49e-06	2	82	2	28130864
Pubmed	Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules.	SAMD4B SAMD4A	5.49e-06	2	82	2	16221671
Pubmed	Selenomethionine promotes ANXA2 phosphorylation for proliferation and protein synthesis of myoblasts and skeletal muscle growth.	ANXA2 ANXA2P2	5.49e-06	2	82	2	36739096
Pubmed	Localization of annexin II in the paranodal regions and Schmidt-Lanterman incisures in the peripheral nervous system.	ANXA2 ANXA2P2	5.49e-06	2	82	2	17549680
Pubmed	Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia.	ANXA2 ANXA2P2	5.49e-06	2	82	2	22517898
Pubmed	Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice.	ANXA2 ANXA2P2	5.49e-06	2	82	2	39384746
Pubmed	Anxa2 gene silencing attenuates obesity-induced insulin resistance by suppressing the NF-κB signaling pathway.	ANXA2 ANXA2P2	5.49e-06	2	82	2	30462534
Pubmed	Annexin A2 mediates up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells.	ANXA2 ANXA2P2	5.49e-06	2	82	2	20826156
Pubmed	Prohibitin/annexin 2 interaction regulates fatty acid transport in adipose tissue.	ANXA2 ANXA2P2	5.49e-06	2	82	2	27468426
Pubmed	Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis.	ANXA2 ANXA2P2	5.49e-06	2	82	2	38092984
Pubmed	Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer.	ANXA2 ANXA2P2	5.49e-06	2	82	2	21572519
Pubmed	Rescue of glutaric aciduria type I in mice by liver-directed therapies.	AASS GCDH	5.49e-06	2	82	2	37075130
Pubmed	Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis.	ANXA2 ANXA2P2	5.49e-06	2	82	2	19841537
Pubmed	Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice.	ANXA2 ANXA2P2	5.49e-06	2	82	2	21788340
Pubmed	The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of Cryptococcus neoformans and Impacts Survival in Fungal Infection.	ANXA2 ANXA2P2	5.49e-06	2	82	2	27371724
Pubmed	Novel evidences for a tumor suppressor role of Rev3, the catalytic subunit of Pol zeta.	CHEK2 REV3L	5.49e-06	2	82	2	18622427
Pubmed	Annexin A2 Modulates ROS and Impacts Inflammatory Response via IL-17 Signaling in Polymicrobial Sepsis Mice.	ANXA2 ANXA2P2	5.49e-06	2	82	2	27389701
Pubmed	Annexin A2 Deficiency Exacerbates Neuroinflammation and Long-Term Neurological Deficits after Traumatic Brain Injury in Mice.	ANXA2 ANXA2P2	5.49e-06	2	82	2	31817350
Pubmed	ANNEXIN A2 FACILITATES NEOVASCULARIZATION TO PROTECT AGAINST MYOCARDIAL INFARCTION INJURY VIA INTERACTING WITH MACROPHAGE YAP AND ENDOTHELIAL INTEGRIN Β3.	ANXA2 ANXA2P2	5.49e-06	2	82	2	37832154
Pubmed	Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation.	ANXA2 ANXA2P2	5.49e-06	2	82	2	17360942
Pubmed	Annexin A2 regulates phagocytosis of photoreceptor outer segments in the mouse retina.	ANXA2 ANXA2P2	5.49e-06	2	82	2	19587120
Pubmed	Cell-surface translocation of annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice.	ANXA2 ANXA2P2	5.49e-06	2	82	2	30902828
Pubmed	Annexin A2 at the interface between F-actin and membranes enriched in phosphatidylinositol 4,5,-bisphosphate.	ANXA2 ANXA2P2	5.49e-06	2	82	2	19022301
Pubmed	Cell surface translocation of annexin A2 facilitates glutamate-induced extracellular proteolysis.	ANXA2 ANXA2P2	5.49e-06	2	82	2	24742684
Pubmed	Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections.	ANXA2 ANXA2P2	5.49e-06	2	82	2	32687500
Pubmed	Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris.	ANXA2 ANXA2P2	5.49e-06	2	82	2	22453828
Pubmed	Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-κB Pro-inflammatory Signaling in Ischemic Reperfusion Injury.	ANXA2 ANXA2P2	5.49e-06	2	82	2	38253182
Pubmed	Agents that bind annexin A2 suppress ocular neovascularization.	ANXA2 ANXA2P2	5.49e-06	2	82	2	20607799
Pubmed	A new role for host annexin A2 in establishing bacterial adhesion to vascular endothelial cells: lines of evidence from atomic force microscopy and an in vivo study.	ANXA2 ANXA2P2	5.49e-06	2	82	2	31253864
Pubmed	Annexin A2 is a novel cellular redox regulatory protein involved in tumorigenesis.	ANXA2 ANXA2P2	5.49e-06	2	82	2	22185818
Pubmed	Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo.	ANXA2 ANXA2P2	5.49e-06	2	82	2	19628708
Pubmed	Annexin A2 binds to the localization signal in the 3' untranslated region of c-myc mRNA.	ANXA2 ANXA2P2	5.49e-06	2	82	2	15654879
Pubmed	Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis.	ANXA2 ANXA2P2	5.49e-06	2	82	2	20847146
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CARMIL2 AASS SYDE2 RAB3GAP2 SAMD4B NELFB GIGYF1 GNAS INPP5F HECTD1 SAMD4A	5.68e-06	861	82	11	36931259
Pubmed	STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2 in osteoporosis.	ANXA2 ANXA2P2	1.64e-05	3	82	2	35098646
Pubmed	Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor - AKT/ERK pathways.	ANXA2 ANXA2P2	1.64e-05	3	82	2	36367512
Pubmed	Revealing Annexin A2 and ARF-6 enrollment during Trypanosoma cruzi extracellular amastigote-host cell interaction.	ANXA2 ANXA2P2	1.64e-05	3	82	2	26416603
Pubmed	Annexin A2 depletion delays EGFR endocytic trafficking via cofilin activation and enhances EGFR signaling and metastasis formation.	ANXA2 ANXA2P2	1.64e-05	3	82	2	23792445
Pubmed	The Annexin A2-Notch regulatory loop in hepatocytes promotes liver fibrosis in NAFLD by increasing osteopontin expression.	ANXA2 ANXA2P2	1.64e-05	3	82	2	35413401
Pubmed	Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases.	ANXA2 ANXA2P2	1.64e-05	3	82	2	28694388
Pubmed	Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation.	CDK5R1 CAPN1	1.64e-05	3	82	2	17121855
Pubmed	High Podocalyxin levels promote cell viability partially through up-regulation of Annexin A2.	ANXA2 ANXA2P2	1.64e-05	3	82	2	27470587
Pubmed	Annexin 2-CXCL12 interactions regulate metastatic cell targeting and growth in the bone marrow.	ANXA2 ANXA2P2	1.64e-05	3	82	2	25139998
Pubmed	Annexins--unique membrane binding proteins with diverse functions.	ANXA2 ANXA2P2	1.64e-05	3	82	2	15169834
Pubmed	Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9.	ANXA2 ANXA2P2	1.64e-05	3	82	2	24808179
Pubmed	Impaired osteoblast differentiation in annexin A2- and -A5-deficient cells.	ANXA2 ANXA2P2	1.64e-05	3	82	2	25222280
Pubmed	The Annexin a2 Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog Pathway.	ANXA2 ANXA2P2	1.64e-05	3	82	2	26963384
Pubmed	Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes.	ANXA2 ANXA2P2	1.64e-05	3	82	2	15064349
Pubmed	Annexin A2 links poor myofiber repair with inflammation and adipogenic replacement of the injured muscle.	ANXA2 ANXA2P2	1.64e-05	3	82	2	28334824
Pubmed	Tenascin-c renders a proangiogenic phenotype in macrophage via annexin II.	ANXA2 ANXA2P2	1.64e-05	3	82	2	28857429
Pubmed	Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B.	ANXA2 ANXA2P2	1.64e-05	3	82	2	31160583
Pubmed	Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF-κB signaling pathway.	ANXA2 ANXA2P2	1.64e-05	3	82	2	35900381
Pubmed	Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment.	ANXA2 ANXA2P2	1.64e-05	3	82	2	22223826
Pubmed	ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane.	ABCG4 ABCA1	1.64e-05	3	82	2	25302608
Pubmed	Annexin A2 promotes phagophore assembly by enhancing Atg16L⁺ vesicle biogenesis and homotypic fusion.	ANXA2 ANXA2P2	1.64e-05	3	82	2	25597631
Pubmed	Annexin A2 regulates TRPA1-dependent nociception.	ANXA2 ANXA2P2	1.64e-05	3	82	2	25355205
Pubmed	Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5' noncoding exons.	ANXA2 ANXA2P2	1.64e-05	3	82	2	8634333
Pubmed	RNASEH1-AS1 induced by H3K27ac stabilizes ANXA2 mRNA to promote the progression of colorectal cancer through recruiting BUD13.	ANXA2 ANXA2P2	1.64e-05	3	82	2	38053379
Pubmed	Chromosomal localization of the human genes for lipocortin I and lipocortin II.	ANXA2 ANXA2P2	1.64e-05	3	82	2	2969496
Pubmed	Upregulation of HDAC9 in hippocampal neurons mediates depression-like behaviours by inhibiting ANXA2 degradation.	ANXA2 ANXA2P2	1.64e-05	3	82	2	37690046
Pubmed	The COP9 signalosome controls ubiquitinylation of ABCA1.	ABCA1 COPS5	1.64e-05	3	82	2	19268428
Pubmed	Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche.	ANXA2 ANXA2P2	1.64e-05	3	82	2	21108988
Pubmed	The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation.	ANXA2 ANXA2P2	1.64e-05	3	82	2	27045038
Pubmed	Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.	ANXA2 ANXA2P2	1.64e-05	3	82	2	37844241
Pubmed	Hepatic Overexpression of Annexin A1 and A2 in Thioacetamide-Primed Mice Protects Them Against Acetaminophen-Induced Liver Failure and Death.	ANXA2 ANXA2P2	1.64e-05	3	82	2	27451051
Pubmed	Neurotoxicity induces cleavage of p35 to p25 by calpain.	CDK5R1 CAPN1	1.64e-05	3	82	2	10830966
Pubmed	FOXQ1 promotes the osteogenic differentiation of bone mesenchymal stem cells via Wnt/β-catenin signaling by binding with ANXA2.	ANXA2 ANXA2P2	1.64e-05	3	82	2	32943107
Pubmed	Prostaglandin-endoperoxide synthase-2 deletion affects the natural trafficking of Annexin A2 in monocytes and favours venous thrombosis in mice.	ANXA2 ANXA2P2	1.64e-05	3	82	2	28536720
Pubmed	ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.	ABCG4 ABCA1	1.64e-05	3	82	2	16902247
Pubmed	Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes.	ANXA2 ANXA2P2	1.64e-05	3	82	2	14726447
Pubmed	The N-methyl-D-aspartate receptor subunits NR2A and NR2B bind to the SH2 domains of phospholipase C-gamma.	PLCG1 GRIN2A	1.64e-05	3	82	2	9231720
Pubmed	Mitochondrially mediated integrin αIIbβ3 protein inactivation limits thrombus growth.	ANXA2 ANXA2P2	1.64e-05	3	82	2	24014035
Pubmed	Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity.	ANXA2 ANXA2P2	1.64e-05	3	82	2	28283478
Pubmed	FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development.	ANXA2 CAPN1 ASTN2	2.16e-05	23	82	3	26124079
Pubmed	ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis.	ABCA1 ABCA12	3.28e-05	4	82	2	23931754
Pubmed	Annexin A2 tetramer activates human and murine macrophages through TLR4.	ANXA2 ANXA2P2	3.28e-05	4	82	2	19965653
Pubmed	A new cis-acting motif is required for the axonal SMN-dependent Anxa2 mRNA localization.	ANXA2 ANXA2P2	3.28e-05	4	82	2	28258160
Pubmed	Regulation of the SHP-2 tyrosine phosphatase by a novel cholesterol- and cell confluence-dependent mechanism.	ANXA2 ANXA2P2	3.28e-05	4	82	2	12611902
Pubmed	Secretion of Annexin II via activation of insulin receptor and insulin-like growth factor receptor.	ANXA2 ANXA2P2	3.28e-05	4	82	2	12431980
Pubmed	Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells.	ANXA2 ANXA2P2	3.28e-05	4	82	2	23525114
Pubmed	Disruption of the nuclear hormone receptor RORalpha in staggerer mice.	ANXA2 ANXA2P2	3.28e-05	4	82	2	8602221
Pubmed	The protein-protein interaction between connective tissue growth factor and annexin A2 is relevant to pannus formation in rheumatoid arthritis.	ANXA2 ANXA2P2	3.28e-05	4	82	2	34702315
Pubmed	The annexins: specific markers of midline structures and sensory neurons in the developing murine central nervous system.	ANXA2 ANXA2P2	3.28e-05	4	82	2	7706559
Pubmed	Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport.	ANXA2 ANXA2P2	3.28e-05	4	82	2	15078881
Pubmed	Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11.	ANXA2 ANXA2P2	3.28e-05	4	82	2	18434302
Pubmed	Structure of an asymmetric ternary protein complex provides insight for membrane interaction.	ANXA2 ANXA2P2	3.28e-05	4	82	2	22940583
GeneFamily	ATP binding cassette subfamily A	ABCA1 ABCA12	6.15e-04	14	48	2	805
GeneFamily	GCN5 related N-acetyltransferases	AANAT NAT10	1.84e-03	24	48	2	1134
Disease	renal cell carcinoma (biomarker_via_orthology)	ANXA2 ANXA2P2	6.31e-04	14	79	2	DOID:4450 (biomarker_via_orthology)
Disease	Alzheimer's disease (is_marker_for)	CDK5R1 CAPN1 PLCG1 GRIN2A GNAS	6.43e-04	257	79	5	DOID:10652 (is_marker_for)
Disease	polycystic kidney disease (biomarker_via_orthology)	GNAS C9	1.18e-03	19	79	2	DOID:0080322 (biomarker_via_orthology)
Disease	Depression, Bipolar	AANAT HDAC5 GRIN2A	1.26e-03	79	79	3	C0005587
Disease	hypothyroidism (biomarker_via_orthology)	CDK5R1 ANXA2 ANXA2P2	1.31e-03	80	79	3	DOID:1459 (biomarker_via_orthology)
Disease	hyperthyroidism (biomarker_via_orthology)	ANXA2 ANXA2P2	2.56e-03	28	79	2	DOID:7998 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LCHLSLMEKDLGTTA	GNAS	161	P84996
ILSDTCALSHGDRLM	ACSM6	101	Q6P461
DSCKTTIEAIHGLMS	COPS5	306	Q92905
VTEILTALGLMSCSH	ABCG4	181	Q9H172
TALGLMSCSHTRTAL	ABCG4	186	Q9H172
MLCRDVISSEVGSDH	CDK5R1	206	Q15078
SVILTSHSMEECEAL	ABCA12	2441	Q86UK0
KMVLCIATDDSHSLS	AZIN2	151	Q96A70
MSQSSHLEELVLETC	CARMIL2	241	Q6F5E8
LASCHSLMQLDDGTL	ATP13A1	571	Q9HD20
SVVLTSHSMEECEAL	ABCA1	2096	O95477
IHDSVEGSGILMCSI	AASS	386	Q9UDR5
CIESEHSMDTLLATL	ATOX1	41	O00244
MSTVHEILCKLSLEG	ANXA2	1	P07355
SLLGCSIDISSVLDM	CAPN1	246	P07384
HSKILGETSLMRTLC	CHEK2	371	O96017
MSTVHEILCKLSLEG	ANXA2P2	1	A6NMY6
TLEMSGTAADISLVH	ASTN2	146	O75129
VDLGVCLHMSSSGLD	ALG1L	56	Q6GMV1
SLMADLEGLHLSTSS	AP3B1	841	O00203
EHCVLTSTGDIMVTS	NWD2	1361	Q9ULI1
TIDHFICDSSPMLLI	OR6C65	171	A6NJZ3
STEDMCHTLESAGLS	RAB3GAP2	751	Q9H2M9
CEQMLHTLSATGSLD	GIGYF1	906	O75420
SIVSSEEDGLHLVTM	KCNJ12	11	Q14500
EHVLALTMLCLTEGA	NPM3	61	O75607
SSCAALEMPIHSDIL	IBTK	806	Q9P2D0
VMATELAHSLRCSAE	PHKA1	926	P46020
IHSSIVSTLLALMDG	ATAD2B	521	Q9ULI0
AATVSEHTMLLEGTA	KIAA1109	2206	Q2LD37
RTGMVHCLSEIELLA	PDE1B	241	Q01064
ETICLVTGTHKMLSA	FAM234B	221	A2RU67
LLMSLHDLDVGEICT	NELFB	241	Q8WX92
LASCIHMEIEGVRSL	LRGUK	506	Q96M69
TGEHSCIMLKTLTDE	NAT10	741	Q9H0A0
SGEITASLCKMLTHA	LRRC66	581	Q68CR7
EHTAVISLCSGMLGT	ADAMTS9	161	Q9P2N4
DTLHSAMAVVSRLCG	HECTD1	161	Q9ULT8
CSDIHDTLGHMLSSL	HEATR5B	1166	Q9P2D3
LADMLTEITLGLHAC	GCDH	336	Q92947
SELQHLSLGSCVMIE	FBXL4	451	Q9UKA2
TSALHIVVGDSLAMD	CERK	256	Q8TCT0
HSSSAVRMAVGCLLE	HDAC5	796	Q9UQL6
ESLHSILAGSDMTVS	HIRA	811	P54198
HILSIDGTSMEHCSL	GRIP2	296	Q9C0E4
LSPVVECMDHALTSL	DHRS9	261	Q9BPW9
AMALTLTLCAASIGH	SLC22A25	231	Q6T423
TSASSMLELETGLHV	INPP5F	1041	Q9Y2H2
SMLGTALVLFHSCEE	SLC39A12	381	Q504Y0
CGSIEELTSDHISMV	SACS	1321	Q9NZJ4
LTESSGSASHIDCRM	C9	31	P02748
SVHLGCSEEMLTIVS	DHX8	996	Q14562
LSLMPSLTSGEVAHC	TBRG4	321	Q969Z0
CLSALSMITERHGLK	NR4A3	536	Q92570
TALLTCRTTFLDMDH	SYDE2	716	Q5VT97
ELTHIMVGLESCSFL	PMPCA	316	Q10713
SEDGAHTLTCALMLL	PSD	646	A5PKW4
ITVGSLTFMELHCSL	AANAT	181	Q16613
LLAHMTGSVDLTCTS	NBEA	1186	Q8NFP9
IILCMEALDHTPDTS	PRC1	181	O43663
MLSLLHTSTLAVLGA	TRGV9	1	Q99603
SVDIEHMSSGLTDLL	SCFD2	591	Q8WU76
LAGRVACAMSSHELL	SKIV2L	1076	Q15477
LLIQHVMTSDTSGIC	SEMA4C	536	Q9C0C4
LHTGMGRLCTLDESV	NIF3L1	246	Q9GZT8
LSCLSQHGSILMSIL	STK36	941	Q9NRP7
ICDHLTSFSILMSPD	ADGRF5	986	Q8IZF2
ALMSVLLLHLCGESE	CCL20	11	P78556
EVLLTLCGDDTLKMH	CIP2A	421	Q8TCG1
GSLSVEDSVECLHAM	CLTCL1	656	P53675
SVSSMLLEGHTLLAL	SPG11	1071	Q96JI7
CIELFTTMETLGEHD	USP4	781	Q13107
HTLSCLSLSEAASMS	TDRKH	536	Q9Y2W6
LLSCSGENRTMVHSL	REV3L	746	O60673
TLESLCLSMTEHALG	SAMD4B	671	Q5PRF9
TSEDGIHTLTCALML	PSD2	401	Q9BQI7
SSLHQLTAMVDCRGL	TTYH2	356	Q9BSA4
SGNELCLMTSHLEST	TDP2	216	O95551
EVLHLCRSLEVGTVM	PLCG1	21	P19174
LIHSMATVDFLLGCL	TAAR1	61	Q96RJ0
LESLCLSMTEHALGD	SAMD4A	696	Q9UPU9
ACHAELLRTISTTMG	TBRG1	266	Q3YBR2
DASGLMSHCIAILKI	TMEM98	86	Q9Y2Y6
LLCSTEMDSLLRPHT	ZNF641	251	Q96N77
TGCSMESALEAASLH	AMDHD2	346	Q9Y303
SLITHVCDLMSGARI	GRIN2A	81	Q12879