Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone binding	NAP1L3 CBX3 SMARCC2 NBN CHD4	1.37e-05	265	24	5	GO:0042393
GeneOntologyMolecularFunction	phosphorylation-dependent protein binding	NBN ANK3	6.19e-05	10	24	2	GO:0140031
GeneOntologyMolecularFunction	transcription factor binding	CBX3 NBN CHD4 ZNHIT6 TCERG1 CTCF	2.12e-04	753	24	6	GO:0008134
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	CBX3 NBN CHD4 TCERG1 CTCF	5.55e-04	582	24	5	GO:0140297
GeneOntologyMolecularFunction	transcription coregulator binding	CBX3 CHD4 CTCF	6.13e-04	140	24	3	GO:0001221
GeneOntologyMolecularFunction	chromatin DNA binding	SMARCC2 CHD4 CTCF	1.02e-03	167	24	3	GO:0031490
GeneOntologyMolecularFunction	chromatin binding	NAP1L3 CBX3 SMARCC2 CHD4 CTCF	1.62e-03	739	24	5	GO:0003682
GeneOntologyMolecularFunction	modification-dependent protein binding	CBX3 NBN ANK3	1.87e-03	206	24	3	GO:0140030
GeneOntologyMolecularFunction	RNA polymerase binding	CCAR2 TCERG1	2.75e-03	65	24	2	GO:0070063
GeneOntologyMolecularFunction	basal RNA polymerase II transcription machinery binding	CCAR2 ZNHIT6	2.83e-03	66	24	2	GO:0001099
GeneOntologyMolecularFunction	basal transcription machinery binding	CCAR2 ZNHIT6	2.83e-03	66	24	2	GO:0001098
GeneOntologyMolecularFunction	nucleosomal DNA binding	SMARCC2 CHD4	2.92e-03	67	24	2	GO:0031492
GeneOntologyMolecularFunction	molecular adaptor activity	SMARCC2 NBN CHD4 ANK3 TCERG1 CTCF	4.52e-03	1356	24	6	GO:0060090
GeneOntologyMolecularFunction	nucleosome binding	SMARCC2 CHD4	6.13e-03	98	24	2	GO:0031491
GeneOntologyCellularComponent	chromosomal region	CBX3 SMARCC2 NBN CHD4 CTCF	1.00e-04	421	24	5	GO:0098687
GeneOntologyCellularComponent	site of DNA damage	CBX3 NBN CHD4	5.04e-04	137	24	3	GO:0090734
GeneOntologyCellularComponent	nuclear periphery	SMARCC2 TCERG1 ANAPC4	9.59e-04	171	24	3	GO:0034399
GeneOntologyCellularComponent	chromosome, telomeric region	CBX3 NBN CHD4	1.04e-03	176	24	3	GO:0000781
Domain	CHROMO	CBX3 SMARCC2 CHD4	9.92e-06	33	24	3	SM00298
Domain	Chromo/shadow_dom	CBX3 SMARCC2 CHD4	9.92e-06	33	24	3	IPR000953
Domain	Chromo_domain	CBX3 CHD4	4.29e-04	24	24	2	IPR023780
Domain	Chromo	CBX3 CHD4	5.05e-04	26	24	2	PF00385
Domain	CHROMO_2	CBX3 CHD4	5.86e-04	28	24	2	PS50013
Domain	CHROMO_1	CBX3 CHD4	5.86e-04	28	24	2	PS00598
Domain	BRCT_dom	SMARCC2 NBN	5.86e-04	28	24	2	IPR001357
Domain	Chromodomain-like	CBX3 CHD4	7.67e-04	32	24	2	IPR016197
Domain	WD40_repeat_dom	CFAP44 WDR87 ANAPC4	6.29e-03	297	24	3	IPR017986
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CBX3 SMARCC2 NBN CHD4 GIGYF1 ZNHIT6 CLPX CTCF ANAPC4	4.49e-08	1116	25	9	31753913
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	SMARCC2 EPRS1 NBN CCAR2 CHD4 TCERG1	1.26e-07	340	25	6	24332808
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CBX3 EPRS1 NBN CHD4 DST TCERG1 CTCF ANAPC4	1.89e-07	934	25	8	33916271
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	CBX3 SMARCC2 EPRS1 NBN CCAR2 CHD4 ZNHIT6 WDR87 ANAPC4	2.06e-07	1335	25	9	29229926
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CBX3 SMARCC2 EPRS1 NBN CHD4 TCERG1 CTCF ANAPC4	2.22e-07	954	25	8	36373674
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SAE1 CBX3 SMARCC2 EPRS1 CCAR2 CHD4 DST CLPX TCERG1	2.31e-07	1353	25	9	29467282
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	SAE1 CBX3 SMARCC2 NBN CCAR2 CHD4 TCERG1 CTCF	3.53e-07	1014	25	8	32416067
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	SAE1 CBX3 EPRS1 CCAR2 CHD4 DST ANK3 TCERG1	9.08e-07	1149	25	8	35446349
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	SMARCC2 NBN CCAR2 CHD4 TCERG1	1.29e-06	271	25	5	32433965
Pubmed	Inhibition of histone binding by supramolecular hosts.	CBX3 CHD4	1.49e-06	3	25	2	24576085
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SAE1 CBX3 SMARCC2 EPRS1 CHD4 CLPX TCERG1 CTCF	3.39e-06	1371	25	8	36244648
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	SAE1 EPRS1 CCAR2 CHD4 TCERG1	3.49e-06	332	25	5	32786267
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CBX3 SMARCC2 CCAR2 CHD4 DST ANK3 CTCF	3.79e-06	963	25	7	28671696
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	CBX3 SMARCC2 CHD4 CTCF	3.92e-06	150	25	4	28242625
Pubmed	Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.	CBX3 SMARCC2 GIGYF1	3.97e-06	43	25	3	36950384
Pubmed	Human transcription factor protein interaction networks.	SMARCC2 NBN CCAR2 GIGYF1 DST CLPX TCERG1 CTCF	4.61e-06	1429	25	8	35140242
Pubmed	A protein interaction landscape of breast cancer.	SMARCC2 DST CLPX ANK3 CTCF ANAPC4	4.72e-06	634	25	6	34591612
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CBX3 SMARCC2 EPRS1 CCAR2 CHD4 DST CLPX ARMC3	4.93e-06	1442	25	8	35575683
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	EPRS1 GIGYF1 ZNHIT6 DST CLPX TCERG1	5.45e-06	650	25	6	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CBX3 SMARCC2 CCAR2 CHD4 DST CTCF	5.59e-06	653	25	6	22586326
Pubmed	Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners.	CBX3 SMARCC2 CHD4	5.91e-06	49	25	3	19759913
Pubmed	Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.	SMARCC2 CCAR2 CHD4	7.51e-06	53	25	3	21532573
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	CBX3 SMARCC2 EPRS1 NBN CTCF	8.02e-06	394	25	5	27248496
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	SMARCC2 NBN CCAR2 TCERG1 ANAPC4	8.22e-06	396	25	5	26687479
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	CBX3 SMARCC2 NBN CHD4	8.42e-06	182	25	4	26527279
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	FSIP2 SAE1 SMARCC2 CCAR2 TCERG1	8.52e-06	399	25	5	35987950
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	EPRS1 NBN ZNHIT6 CTCF ANAPC4	1.08e-05	419	25	5	28700943
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CBX3 SMARCC2 CCAR2 ZNHIT6 CLPX CTCF ANAPC4	1.24e-05	1155	25	7	20360068
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	CBX3 EPRS1 CCAR2 CHD4 TCERG1	1.38e-05	441	25	5	31239290
Pubmed	Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II.	CBX3 CHD4	1.39e-05	8	25	2	22308494
Pubmed	ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.	CBX3 CHD4	1.39e-05	8	25	2	32533114
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	PCSK1 SAE1 CBX3 EPRS1 CCAR2 CHD4	1.60e-05	786	25	6	29128334
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	CBX3 SMARCC2 EPRS1 CHD4 DST ANK3	1.86e-05	807	25	6	30575818
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	SAE1 CBX3 SMARCC2 EPRS1 CHD4 CTCF WDR87	2.04e-05	1247	25	7	27684187
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	CBX3 EPRS1 CCAR2 CHD4	2.38e-05	237	25	4	29564676
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	CBX3 SMARCC2 EPRS1 CHD4 TCERG1 CTCF	2.44e-05	847	25	6	35850772
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	SAE1 SMARCC2 EPRS1 CCAR2 CHD4 TCERG1	2.44e-05	847	25	6	35235311
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CBX3 EPRS1 NBN CHD4 DST TCERG1 CTCF	2.59e-05	1294	25	7	30804502
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	SMARCC2 EPRS1 CHD4 DST TCERG1	2.67e-05	506	25	5	30890647
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	SAE1 CBX3 EPRS1 CCAR2 CHD4 CLPX TCERG1	2.91e-05	1318	25	7	30463901
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	CBX3 SMARCC2 CHD4 TCERG1 CTCF	3.42e-05	533	25	5	30554943
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	SAE1 CBX3 EPRS1 NBN CHD4	3.45e-05	534	25	5	35032548
Pubmed	The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.	CBX3 CHD4	3.85e-05	13	25	2	15882967
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	CBX3 SMARCC2 EPRS1 CCAR2 CHD4 CLPX TCERG1	4.58e-05	1415	25	7	28515276
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	CBX3 EPRS1 CCAR2 CHD4 CLPX TCERG1 KIAA0586	4.79e-05	1425	25	7	30948266
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	CBX3 CCAR2 CHD4 TCERG1 CTCF	5.24e-05	583	25	5	29844126
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	CBX3 SMARCC2 CCAR2 CHD4 TCERG1 CTCF	5.80e-05	989	25	6	36424410
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	SAE1 SMARCC2 EPRS1 CHD4 CTCF	6.05e-05	601	25	5	33658012
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	CBX3 SMARCC2 EPRS1 CCAR2 CHD4	6.24e-05	605	25	5	28977666
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CBX3 SMARCC2 EPRS1 CCAR2 CHD4 DST	7.03e-05	1024	25	6	24711643
Pubmed	Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.	SMARCC2 ANK3	7.54e-05	18	25	2	33323119
Pubmed	Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region.	SMARCC2 CHD4	7.54e-05	18	25	2	16217013
Pubmed	TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.	SMARCC2 CHD4	7.54e-05	18	25	2	28068325
Pubmed	The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.	EPRS1 CCAR2 CHD4 GIGYF1	7.64e-05	320	25	4	28685749
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	CBX3 SMARCC2 CHD4	7.88e-05	116	25	3	21549307
Pubmed	Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.	CBX3 NBN CHD4	7.88e-05	116	25	3	37117180
Pubmed	EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.	CCAR2 ANAPC4	8.42e-05	19	25	2	18445686
Pubmed	Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction.	SMARCC2 NBN	8.42e-05	19	25	2	16932743
Pubmed	LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet β-cell function.	SMARCC2 CCAR2	8.42e-05	19	25	2	31186351
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	FSIP2 DST CLPX ANK3	8.70e-05	331	25	4	29199018
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	CBX3 SMARCC2 NBN CCAR2 CHD4	8.88e-05	652	25	5	31180492
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	CBX3 EPRS1 CHD4 GIGYF1 CTCF	9.07e-05	655	25	5	35819319
Pubmed	QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function.	DST ANK3	9.35e-05	20	25	2	33397958
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	FSIP2 CCAR2 DST	9.38e-05	123	25	3	26912792
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	SAE1 SMARCC2 EPRS1 CCAR2 CHD4 TCERG1	1.06e-04	1103	25	6	34189442
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	NBN CCAR2 CHD4 CTCF	1.07e-04	349	25	4	25665578
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	CBX3 EPRS1 CCAR2 CHD4 TCERG1	1.30e-04	707	25	5	19738201
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	CBX3 EPRS1 DST ANK3 TCERG1	1.31e-04	708	25	5	39231216
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	NBN CCAR2 CHD4	1.53e-04	145	25	3	28846114
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	CBX3 EPRS1 CCAR2 CHD4	1.78e-04	399	25	4	37536630
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	SMARCC2 EPRS1 TCERG1	1.82e-04	154	25	3	16055720
Pubmed	Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.	SAE1 SMARCC2 ANK3 TCERG1	1.85e-04	403	25	4	35253629
Pubmed	Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.	NBN CHD4 TCERG1	1.89e-04	156	25	3	37108203
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	SAE1 NBN CHD4	1.93e-04	157	25	3	30686591
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SMARCC2 EPRS1 NBN CCAR2 CHD4	1.98e-04	774	25	5	15302935
Pubmed	Analysis of the human HP1 interactome reveals novel binding partners.	CBX3 CHD4	1.99e-04	29	25	2	21888893
Pubmed	RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.	SMARCC2 CHD4	1.99e-04	29	25	2	36800290
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	SMARCC2 NBN CHD4 TCERG1	2.00e-04	411	25	4	35182466
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	CBX3 SMARCC2 EPRS1 CHD4	2.00e-04	411	25	4	36652389
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	CBX3 CHD4	2.13e-04	30	25	2	17403666
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	SAE1 EPRS1 CCAR2 ZNHIT6 CLPX TCERG1	2.16e-04	1257	25	6	37317656
Pubmed	Placing the HIRA histone chaperone complex in the chromatin landscape.	SMARCC2 CTCF	2.28e-04	31	25	2	23602572
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NAP1L3 EPRS1 CHD4 DST ANK3 TCERG1	2.43e-04	1285	25	6	35914814
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	CBX3 SMARCC2 CHD4	2.44e-04	170	25	3	16159877
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	CBX3 SMARCC2 CHD4 ANAPC4	2.59e-04	440	25	4	34244565
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	CBX3 SMARCC2 CHD4	2.79e-04	178	25	3	27637333
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	CBX3 SMARCC2 CHD4	2.88e-04	180	25	3	30110629
Pubmed	Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.	CBX3 SMARCC2	2.91e-04	35	25	2	22325351
Pubmed	A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.	CCAR2 ZNHIT6	2.91e-04	35	25	2	23382074
Pubmed	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.	CBX3 SMARCC2 CHD4	3.03e-04	183	25	3	36129980
Pubmed	Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation.	SMARCC2 CHD4	3.25e-04	37	25	2	24335282
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	NBN DST CTCF ANAPC4	3.38e-04	472	25	4	38943005
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	EPRS1 ANK3 TCERG1	3.43e-04	191	25	3	20195357
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	CBX3 CHD4	3.43e-04	38	25	2	33283408
Pubmed	A human MAP kinase interactome.	CBX3 DST ANK3 TCERG1	3.77e-04	486	25	4	20936779
Pubmed	Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1.	SMARCC2 CHD4	3.80e-04	40	25	2	34585037
Pubmed	Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment.	EPRS1 CCAR2 CHD4 TCERG1	3.92e-04	491	25	4	22623428
Pubmed	Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.	CHD4 TCERG1	4.00e-04	41	25	2	15561718
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	SMARCC2 CHD4 TCERG1	4.10e-04	203	25	3	22083510
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	CBX3 EPRS1 NBN GIGYF1	4.30e-04	503	25	4	16964243
Interaction	H3C1 interactions	CBX3 SMARCC2 EPRS1 NBN CHD4 CLPX ANK3 CTCF WDR87	7.33e-07	901	25	9	int:H3C1
Interaction	H3C15 interactions	FSIP2 CBX3 EPRS1 CHD4 CLPX	4.90e-06	207	25	5	int:H3C15
Interaction	SUMO2 interactions	SAE1 EPRS1 NBN CCAR2 CHD4 DST TCERG1	5.46e-06	591	25	7	int:SUMO2
Interaction	MDC1 interactions	CBX3 SMARCC2 NBN CHD4 CTCF ANAPC4	9.22e-06	414	25	6	int:MDC1
Interaction	H2BC9 interactions	FSIP2 SMARCC2 EPRS1 CHD4 DST CFAP44	1.41e-05	446	25	6	int:H2BC9
Interaction	NAA40 interactions	CBX3 EPRS1 NBN CHD4 DST TCERG1 CTCF ANAPC4	1.54e-05	978	25	8	int:NAA40
Interaction	BAP1 interactions	SAE1 CBX3 EPRS1 NBN CCAR2 CHD4 DST ANK3 TCERG1	1.63e-05	1314	25	9	int:BAP1
Interaction	SMC5 interactions	CBX3 SMARCC2 EPRS1 NBN CHD4 TCERG1 CTCF ANAPC4	1.81e-05	1000	25	8	int:SMC5
Interaction	PRMT5 interactions	SMARCC2 NBN CCAR2 ZNHIT6 DST TCERG1	1.92e-05	471	25	6	int:PRMT5
Interaction	ADARB1 interactions	SMARCC2 NBN CCAR2 CHD4 TCERG1 CTCF	2.37e-05	489	25	6	int:ADARB1
Interaction	RECQL4 interactions	CBX3 SMARCC2 EPRS1 NBN CCAR2 CHD4 ZNHIT6 WDR87 ANAPC4	2.90e-05	1412	25	9	int:RECQL4
Interaction	H2BC12 interactions	SAE1 CBX3 EPRS1 CHD4 DST	4.12e-05	322	25	5	int:H2BC12
Interaction	TERF2IP interactions	CBX3 SMARCC2 NBN TCERG1 CTCF ANAPC4	4.67e-05	552	25	6	int:TERF2IP
Interaction	SETD1A interactions	CBX3 CHD4 TCERG1 CTCF	5.38e-05	170	25	4	int:SETD1A
Interaction	BRD1 interactions	CBX3 CHD4 CLPX CTCF ANAPC4	5.65e-05	344	25	5	int:BRD1
Interaction	HDLBP interactions	SAE1 CBX3 SMARCC2 CHD4 CLPX TCERG1 CTCF	5.93e-05	855	25	7	int:HDLBP
Interaction	POU5F1 interactions	SMARCC2 NBN CCAR2 CHD4 TCERG1 ANAPC4	6.39e-05	584	25	6	int:POU5F1
Interaction	BRCA1 interactions	CBX3 SMARCC2 EPRS1 NBN CCAR2 DST CLPX ANAPC4	8.90e-05	1249	25	8	int:BRCA1
Interaction	SMARCAD1 interactions	CBX3 SMARCC2 CHD4 ANK3	9.54e-05	197	25	4	int:SMARCAD1
Interaction	SUZ12 interactions	CBX3 SMARCC2 EPRS1 CCAR2 CHD4 CTCF	1.10e-04	644	25	6	int:SUZ12
Interaction	LIG3 interactions	CBX3 NBN CHD4 CLPX	1.15e-04	207	25	4	int:LIG3
Interaction	DDX42 interactions	CBX3 EPRS1 CHD4 TCERG1	1.18e-04	208	25	4	int:DDX42
Interaction	PCGF1 interactions	CBX3 SMARCC2 TCERG1 CTCF	1.18e-04	208	25	4	int:PCGF1
Interaction	RBAK interactions	CBX3 CTCF ZNF710	1.35e-04	81	25	3	int:RBAK
Interaction	H3C6 interactions	CBX3 SMARCC2 NBN CHD4	1.62e-04	226	25	4	int:H3C6
Interaction	H2BC21 interactions	CBX3 SMARCC2 EPRS1 NBN CHD4 ANAPC4	1.68e-04	696	25	6	int:H2BC21
Interaction	MEN1 interactions	CBX3 SMARCC2 EPRS1 NBN CHD4 TCERG1 CTCF	1.89e-04	1029	25	7	int:MEN1
Interaction	RAD18 interactions	CBX3 EPRS1 NBN CHD4 CTCF	2.14e-04	457	25	5	int:RAD18
Interaction	SIRT7 interactions	CBX3 SMARCC2 CCAR2 CHD4 DST CTCF	2.41e-04	744	25	6	int:SIRT7
Interaction	UBA2 interactions	SAE1 CBX3 ZNHIT6 TCERG1	2.49e-04	253	25	4	int:UBA2
Interaction	MCPH1 interactions	SMARCC2 NBN CHD4	2.59e-04	101	25	3	int:MCPH1
Interaction	CHD3 interactions	CBX3 SMARCC2 EPRS1 CCAR2 CHD4 TCERG1	2.64e-04	757	25	6	int:CHD3
Interaction	NANOG interactions	CBX3 NBN CCAR2 CHD4 ANAPC4	2.71e-04	481	25	5	int:NANOG
Interaction	H2BC4 interactions	FSIP2 SAE1 SMARCC2 EPRS1	2.73e-04	259	25	4	int:H2BC4
Interaction	TOP2B interactions	CBX3 SMARCC2 CHD4 CTCF	3.02e-04	266	25	4	int:TOP2B
Interaction	ATRX interactions	CBX3 NBN TCERG1 CTCF	3.06e-04	267	25	4	int:ATRX
Interaction	BRD3 interactions	CBX3 SMARCC2 CHD4 TCERG1 CTCF	3.07e-04	494	25	5	int:BRD3
Interaction	AIM2 interactions	NBN CHD4 CTCF	3.33e-04	110	25	3	int:AIM2
Interaction	USP37 interactions	CBX3 CCAR2 ANAPC4	3.80e-04	115	25	3	int:USP37
Interaction	FMR1 interactions	CBX3 SMARCC2 EPRS1 CCAR2 CHD4	4.46e-04	536	25	5	int:FMR1
Interaction	USP15 interactions	SMARCC2 CCAR2 CHD4 ANK3 CTCF	4.86e-04	546	25	5	int:USP15
Interaction	NPM1 interactions	CBX3 EPRS1 CHD4 ANK3 TCERG1 CTCF WDR87	4.88e-04	1201	25	7	int:NPM1
Interaction	NOL8 interactions	CBX3 DST TCERG1	5.20e-04	128	25	3	int:NOL8
Interaction	ZSCAN21 interactions	CBX3 CTCF ZNF710	5.20e-04	128	25	3	int:ZSCAN21
Interaction	RNF2 interactions	CBX3 SMARCC2 EPRS1 CHD4 CLPX ANK3	5.43e-04	866	25	6	int:RNF2
Interaction	ITGB2 interactions	CHD4 CLPX TCERG1	5.68e-04	132	25	3	int:ITGB2
Interaction	TRIM52 interactions	CCAR2 ZNHIT6 KIAA0586	5.81e-04	133	25	3	int:TRIM52
Interaction	HIF1AN interactions	CCAR2 CLPX ANK3 CFAP44	5.85e-04	317	25	4	int:HIF1AN
Interaction	MAGEA3 interactions	CCAR2 CHD4 CLPX	5.94e-04	134	25	3	int:MAGEA3
Interaction	H2BC8 interactions	CBX3 SMARCC2 CHD4 TCERG1 CTCF	6.20e-04	576	25	5	int:H2BC8
Interaction	CHAF1A interactions	CBX3 SMARCC2 CHD4 TCERG1	6.21e-04	322	25	4	int:CHAF1A
Interaction	ZNF710 interactions	CTCF ZNF710	6.29e-04	30	25	2	int:ZNF710
Interaction	ZFP3 interactions	CTCF ZNF710	6.29e-04	30	25	2	int:ZFP3
Interaction	KDM5C interactions	CBX3 SMARCC2 CTCF	6.61e-04	139	25	3	int:KDM5C
Interaction	CDC34 interactions	CBX3 EPRS1 CCAR2 CHD4	6.65e-04	328	25	4	int:CDC34
Interaction	HP1BP3 interactions	CBX3 CHD4 CTCF ANAPC4	6.73e-04	329	25	4	int:HP1BP3
Interaction	PRP4K interactions	CBX3 SMARCC2 CHD4 TCERG1	6.73e-04	329	25	4	int:PRP4K
Interaction	DPPA4 interactions	SMARCC2 NBN TCERG1	6.75e-04	140	25	3	int:DPPA4
Interaction	H2AX interactions	CBX3 SMARCC2 NBN CHD4 CTCF	7.07e-04	593	25	5	int:H2AX
Interaction	MYNN interactions	CHD4 ZNF710	7.16e-04	32	25	2	int:MYNN
Interaction	ZNF382 interactions	CTCF ZNF710	7.62e-04	33	25	2	int:ZNF382
Interaction	ZNF697 interactions	CTCF ZNF710	7.62e-04	33	25	2	int:ZNF697
Interaction	AGR2 interactions	CBX3 SMARCC2 EPRS1 CHD4 DST ANK3	8.09e-04	934	25	6	int:AGR2
Interaction	SALL3 interactions	CHD4 CTCF	8.09e-04	34	25	2	int:SALL3
Interaction	CHD7 interactions	CBX3 SMARCC2 CTCF	8.24e-04	150	25	3	int:CHD7
Interaction	KPNA1 interactions	CHD4 ZNHIT6 TCERG1 CTCF	8.57e-04	351	25	4	int:KPNA1
Interaction	ZNF652 interactions	CTCF ZNF710	8.57e-04	35	25	2	int:ZNF652
Interaction	LRRFIP1 interactions	EPRS1 CHD4 CTCF	8.73e-04	153	25	3	int:LRRFIP1
Interaction	NUP43 interactions	FSIP2 CCAR2 DST CTCF ANAPC4	8.96e-04	625	25	5	int:NUP43
Interaction	BIRC3 interactions	CBX3 EPRS1 CCAR2 CHD4 CLPX TCERG1 KIAA0586	9.14e-04	1334	25	7	int:BIRC3
Interaction	SIRT6 interactions	CBX3 SMARCC2 CCAR2 CHD4 ANAPC4	9.15e-04	628	25	5	int:SIRT6
Interaction	PYHIN1 interactions	NBN CCAR2 CHD4 CTCF	9.22e-04	358	25	4	int:PYHIN1
Interaction	CCT8L2 interactions	NBN CHD4 ZNHIT6	9.41e-04	157	25	3	int:CCT8L2
Interaction	MOB3C interactions	CBX3 EPRS1 CCAR2 CHD4	9.81e-04	364	25	4	int:MOB3C
Interaction	WDR3 interactions	CBX3 CCAR2 CHD4	9.93e-04	160	25	3	int:WDR3
Interaction	H2AZ1 interactions	CBX3 SMARCC2 CHD4 CTCF	1.05e-03	371	25	4	int:H2AZ1
Interaction	BRPF3 interactions	CBX3 NBN GIGYF1	1.10e-03	166	25	3	int:BRPF3
Interaction	CCDC8 interactions	SMARCC2 EPRS1 CCAR2 CHD4 DST	1.11e-03	656	25	5	int:CCDC8
Interaction	H1-4 interactions	CBX3 EPRS1 CHD4 CTCF WDR87	1.11e-03	656	25	5	int:H1-4
Interaction	BMI1 interactions	CBX3 NBN CHD4 DST CTCF	1.14e-03	659	25	5	int:BMI1
Interaction	TNIK interactions	SMARCC2 CCAR2 DST ANK3	1.16e-03	381	25	4	int:TNIK
Interaction	H1-2 interactions	PCSK1 EPRS1 NBN CHD4 DST	1.19e-03	666	25	5	int:H1-2
Interaction	RAD21 interactions	CCAR2 CHD4 CTCF ANAPC4	1.20e-03	384	25	4	int:RAD21
Interaction	ZMYM4 interactions	CBX3 CHD4 CTCF	1.20e-03	171	25	3	int:ZMYM4
Interaction	CTNNB1 interactions	PCSK1 CBX3 CHD4 DST ANK3 TCERG1	1.21e-03	1009	25	6	int:CTNNB1
Interaction	EP300 interactions	CBX3 SMARCC2 NBN CCAR2 CHD4 CLPX CTCF	1.22e-03	1401	25	7	int:EP300
Interaction	NR2C2 interactions	SAE1 CBX3 EPRS1 CCAR2 CHD4 CLPX TCERG1	1.23e-03	1403	25	7	int:NR2C2
Interaction	CPNE5 interactions	SAE1 CHD4	1.23e-03	42	25	2	int:CPNE5
Interaction	CIC interactions	CBX3 CCAR2 CHD4 TCERG1 CTCF	1.25e-03	673	25	5	int:CIC
Interaction	ZUP1 interactions	CCAR2 CHD4 CTCF	1.27e-03	174	25	3	int:ZUP1
Interaction	HSPD1 interactions	CBX3 EPRS1 CCAR2 CHD4 CLPX CTCF	1.29e-03	1022	25	6	int:HSPD1
Interaction	SOX2 interactions	CBX3 SMARCC2 EPRS1 CCAR2 CHD4 CTCF ANAPC4	1.33e-03	1422	25	7	int:SOX2
Interaction	PPP4R3A interactions	SMARCC2 CCAR2 CHD4	1.37e-03	179	25	3	int:PPP4R3A
Interaction	HNRNPU interactions	CBX3 EPRS1 CHD4 ZNF35 TCERG1 CTCF	1.38e-03	1035	25	6	int:HNRNPU
Interaction	RNF113A interactions	CBX3 EPRS1 CHD4 GIGYF1 CTCF	1.41e-03	692	25	5	int:RNF113A
Interaction	ACTC1 interactions	SMARCC2 EPRS1 CHD4 DST TCERG1	1.43e-03	694	25	5	int:ACTC1
Interaction	CEBPB interactions	SAE1 CBX3 SMARCC2 EPRS1 CHD4 TCERG1 CTCF	1.45e-03	1443	25	7	int:CEBPB
Interaction	EED interactions	CBX3 SMARCC2 EPRS1 CCAR2 CHD4 TCERG1 CTCF	1.46e-03	1445	25	7	int:EED
Interaction	H2BC3 interactions	SMARCC2 EPRS1 NBN CHD4	1.47e-03	406	25	4	int:H2BC3
Interaction	CELSR3 interactions	DST CTCF	1.48e-03	46	25	2	int:CELSR3
GeneFamily	WD repeat domain containing	CFAP44 WDR87	2.75e-02	262	18	2	362
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF35 CTCF ZNF710	3.26e-02	718	18	3	28
Drug	Thimerosal	FSIP2 CBX3 SMARCC2 EPRS1 CHD4 GIGYF1 DST CFAP44	2.80e-05	1199	25	8	ctd:D013849
Drug	Captopril [62571-86-2]; Down 200; 17.2uM; PC3; HT_HG-U133A	EPRS1 NBN CHD4 ANK3	4.11e-05	179	25	4	4585_DN
Drug	Harmine hydrochloride [343-27-1]; Down 200; 16uM; PC3; HT_HG-U133A	NAP1L3 NBN CLPX KIAA0586	5.18e-05	190	25	4	5855_DN
Drug	Nocodazole [31430-18-9]; Down 200; 13.2uM; PC3; HT_HG-U133A	NBN CLPX ZNF35 KIAA0586	5.51e-05	193	25	4	2076_DN
Disease	rectum cancer (is_implicated_in)	NBN CHD4	2.47e-05	9	25	2	DOID:1993 (is_implicated_in)
Disease	response to corticosteroid	DST ANK3	2.76e-04	29	25	2	GO_0031960
Disease	wellbeing measurement, alcohol consumption measurement	DST KIAA0586	1.79e-03	74	25	2	EFO_0007869, EFO_0007878
Disease	testosterone measurement	PCSK1 SAE1 ANK3 TSBP1 ANAPC4	3.85e-03	1275	25	5	EFO_0004908
Disease	comparative body size at age 10, self-reported	TSBP1 ANAPC4 ZNF710	5.22e-03	420	25	3	EFO_0009819
Disease	sleep measurement	ZNHIT6 CFAP44	5.82e-03	135	25	2	EFO_0004870

Protein segments in the cluster

Peptide	Gene	Start	Entry
EEEAIKEEVVKEPKD	CCAR2	586	Q8N163
EEEASNKPVKIKEEV	ANAPC4	761	Q9UJX5
IENIIVEVKKEPDAE	CTCF	681	P49711
KVEEAEPEEFVVEKV	CBX3	21	Q13185
CVEVDKEVVEGKKEP	CLPX	586	O76031
EKVKEEEEVMVVPKF	ARMC3	691	Q5W041
APAVEEAEEEVKKKI	CFAP44	91	Q96MT7
VKENKVPEELQDKEF	GIGYF1	51	O75420
DKDKEVIPQEIEEVK	DST	7056	Q03001
KEEGIKVFEDQVKEV	FSIP2	6676	Q5CZC0
VVKEAKVGEPEVKEE	ZNHIT6	126	Q9NWK9
DEEPFKIVEKVKEDL	ANK3	1941	Q12955
EKVEKAEVKERTEEP	CHD4	1616	Q14839
PEKEKEDFEKVILED	EPRS1	241	P07814
KPELEIDVKVQKQEE	NBN	571	O60934
VDVKVDTEDIEKKPE	SAE1	106	Q9UBE0
EVKAEEKEVPKEIPE	NAP1L3	201	Q99457
EKEVPKEIPEVKDEE	NAP1L3	206	Q99457
VKDEEKEVPKEIPEV	NAP1L3	216	Q99457
EPKEGQEEVLKEVVE	SMARCC2	826	Q8TAQ2
PVKVKKEEEEEENFP	ZNF35	16	P13682
EEDPKEEPIKEIKEE	TCERG1	491	O14776
EEPIKEIKEEPKEEE	TCERG1	496	O14776
VPKVKFEKVEEEEQE	ZNF710	106	Q8N1W2
PEEQGEIIKVKVKEE	ZBED9	16	Q6R2W3
TEADVPKEQEVQEKK	TSBP1	431	Q5SRN2
KEEVQEKEEVFEEKE	WDR87	2296	Q6ZQQ6
KTPEIMKVDEEEVKF	KIAA0586	836	Q9BVV6
VPEKKECVVKDNDFE	PCSK1	461	P29120