Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	HCN channel complex	HCN4 HCN1	8.85e-05	4	81	2	GO:0098855
Domain	-	MROH9 AP2A1 TRRAP GCN1 AGTPBP1 HTT ARMC8	4.28e-05	222	79	7	1.25.10.10
Domain	Ion_trans_N	HCN4 HCN1	1.05e-04	4	79	2	PF08412
Domain	Ion_trans_N	HCN4 HCN1	1.05e-04	4	79	2	IPR013621
Domain	ARM-like	MROH9 AP2A1 TRRAP GCN1 AGTPBP1 HTT ARMC8	1.46e-04	270	79	7	IPR011989
Domain	ARM-type_fold	MROH9 AP2A1 TRRAP GCN1 AGTPBP1 HTT ARMC8	5.77e-04	339	79	7	IPR016024
Domain	Ion_trans_dom	SCN11A KCNA3 HCN4 HCN1	1.39e-03	114	79	4	IPR005821
Domain	Ion_trans	SCN11A KCNA3 HCN4 HCN1	1.39e-03	114	79	4	PF00520
Domain	K_chnl_volt-dep_EAG/ELK/ERG	HCN4 HCN1	1.56e-03	14	79	2	IPR003938
Domain	cNMP-bd_CS	HCN4 HCN1	2.04e-03	16	79	2	IPR018488
Domain	HEAT_REPEAT	GCN1 HTT ARMC8	3.25e-03	70	79	3	PS50077
Domain	-	UBR5 HERC1	3.86e-03	22	79	2	2.130.10.30
Domain	RCC1/BLIP-II	UBR5 HERC1	4.22e-03	23	79	2	IPR009091
Domain	HECT	UBR5 HERC1	5.79e-03	27	79	2	PF00632
Domain	HECTc	UBR5 HERC1	5.79e-03	27	79	2	SM00119
Domain	HECT_dom	UBR5 HERC1	5.79e-03	27	79	2	IPR000569
Domain	HECT	UBR5 HERC1	5.79e-03	27	79	2	PS50237
Domain	CNMP_BINDING_1	HCN4 HCN1	8.07e-03	32	79	2	PS00888
Domain	CNMP_BINDING_2	HCN4 HCN1	8.07e-03	32	79	2	PS00889
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DIS3L2 OXCT1 AP2A1 MYO1C UBR5 SPR PDCD11 CHD8 RRM1 MAP2K3 TRRAP GCN1 PHGDH ERLIN1 POLR3A NPM3	1.87e-07	1353	86	16	29467282
Pubmed	Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.	CD44 AGTPBP1	6.04e-06	2	86	2	27831556
Pubmed	Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.	HCN4 HCN1	6.04e-06	2	86	2	17548059
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	6.04e-06	2	86	2	11687802
Pubmed	Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.	HCN4 HCN1	6.04e-06	2	86	2	21456027
Pubmed	Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.	HCN4 HCN1	6.04e-06	2	86	2	11675786
Pubmed	Cerebellar mutations affecting the postnatal survival of Purkinje cells in the mouse disclose a longitudinal pattern of differentially sensitive cells.	HERC1 AGTPBP1	6.04e-06	2	86	2	3678603
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	6.04e-06	2	86	2	34910522
Pubmed	Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.	HCN4 HCN1	6.04e-06	2	86	2	19135060
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SYNRG NEK1 KDM3B PDCD11 CHD8 TRRAP GCN1 PHGDH HTT	8.92e-06	549	86	9	38280479
Pubmed	HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.	HCN4 HCN1	1.81e-05	3	86	2	33181864
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	1.81e-05	3	86	2	30801007
Pubmed	Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.	HCN4 HCN1	1.81e-05	3	86	2	22652004
Pubmed	Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.	HCN4 HCN1	1.81e-05	3	86	2	21187420
Pubmed	Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.	HCN4 HCN1	1.81e-05	3	86	2	21945247
Pubmed	Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1	1.81e-05	3	86	2	22006928
Pubmed	EP3 activation facilitates bladder excitability via HCN channels on ICCs.	HCN4 HCN1	1.81e-05	3	86	2	28131828
Pubmed	Nucleolar stress controls mutant Huntington toxicity and monitors Huntington's disease progression.	RRN3P2 HTT	1.81e-05	3	86	2	34880223
Pubmed	Target neuron controls the integrity of afferent axon phenotype: a study on the Purkinje cell-climbing fiber system in cerebellar mutant mice.	HERC1 AGTPBP1	1.81e-05	3	86	2	7891151
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	SCN11A KCNA3 P2RX3 HCN4 HCN1	2.55e-05	139	86	5	16985003
Pubmed	Functional expression of the human HCN3 channel.	HCN4 HCN1	3.61e-05	4	86	2	16043489
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	3.61e-05	4	86	2	18849963
Pubmed	Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.	HCN4 HCN1	3.61e-05	4	86	2	9405696
Pubmed	Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1	3.61e-05	4	86	2	12928435
Pubmed	Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.	HCN4 HCN1	3.61e-05	4	86	2	21615589
Pubmed	Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.	HCN4 HCN1	3.61e-05	4	86	2	20140458
Pubmed	Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.	HCN4 HCN1	3.61e-05	4	86	2	22748890
Pubmed	Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.	HCN4 HCN1	3.61e-05	4	86	2	9630217
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	OXCT1 MYO1C UBR5 CD44 PDCD11 SEC63 RRM1 GCN1 PHGDH ERLIN1 POLR3A NPM3 ARMC8	5.20e-05	1440	86	13	30833792
Pubmed	Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.	HCN4 HCN1	6.01e-05	5	86	2	15564593
Pubmed	Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.	HCN4 HCN1	6.01e-05	5	86	2	34429357
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	6.01e-05	5	86	2	24920589
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	UBR5 KDM3B CHD8	8.26e-05	34	86	3	30894540
Pubmed	Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing.	PCSK1 NDOR1	9.01e-05	6	86	2	35963866
Pubmed	Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.	HCN4 HCN1	9.01e-05	6	86	2	25761792
Pubmed	Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.	UBR5 HTT	9.01e-05	6	86	2	32876667
Pubmed	Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation.	AP2A1 MAP2K3	1.26e-04	7	86	2	16709866
Pubmed	Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.	HCN4 HCN1	1.26e-04	7	86	2	19421833
Pubmed	Nuclear actin and myosin I are required for RNA polymerase I transcription.	MYO1C RRN3P2	1.26e-04	7	86	2	15558034
Pubmed	A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription.	NDOR1 RRN3P2	1.26e-04	7	86	2	28715449
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	OXCT1 AP2A1 MYO1C SPR ASAH1 CD44 KDM3B PDCD11 RRM1 GCN1 PHGDH ERLIN1	1.35e-04	1367	86	12	32687490
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	INTS2 CHD8 TRRAP GCN1 ZFPM2 NPM3 ARMC8	1.67e-04	469	86	7	27634302
Pubmed	Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.	SATB1 UBR5	1.68e-04	8	86	2	20351170
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	1.68e-04	8	86	2	21165971
Pubmed	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.	MYO1C CD44 GCN1 PHGDH	2.16e-04	118	86	4	27377895
Pubmed	International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.	HCN4 HCN1	2.68e-04	10	86	2	16382102
Pubmed	Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.	SYNRG MYO1C UBR5	3.13e-04	53	86	3	35216969
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	3.28e-04	11	86	2	31448880
Pubmed	Activator-Mediator binding regulates Mediator-cofactor interactions.	TRRAP GCN1	3.28e-04	11	86	2	20534441
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	3.28e-04	11	86	2	31776257
Pubmed	A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.	DIS3L2 SGSM3	3.28e-04	11	86	2	19570815
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	AP2A1 MYO1C UBR5 SPR KDM3B PDCD11 SEC63 RRM1 TRRAP PHGDH ERLIN1	3.51e-04	1297	86	11	33545068
Pubmed	Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.	AP2A1 MYO1C GCN1 PHGDH ERLIN1	3.58e-04	244	86	5	28902428
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	OXCT1 AP2A1 UBR5 PDCD11 TRRAP GCN1 POLR3A NPM3	3.59e-04	704	86	8	29955894
Pubmed	Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex.	HCN1 ZFPM2	3.93e-04	12	86	2	25037921
Pubmed	Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.	HCN4 HCN1	3.93e-04	12	86	2	17482496
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SYNRG NDOR1 AP2A1 KDM3B PDCD11 CHD8 HERC1 TRRAP GCN1 HTT	4.01e-04	1105	86	10	35748872
Pubmed	Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model.	RRM1 PHGDH	4.63e-04	13	86	2	19114063
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	MYO1C UBR5 CD44 KDM3B GCN1 PHGDH	4.77e-04	399	86	6	37536630
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	MYO1C UBR5 ACY1 GCN1 PHGDH	5.12e-04	264	86	5	32814769
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	SGTB HERC1 ERLIN1 HTT	5.36e-04	150	86	4	32423001
Pubmed	Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.	HCN4 HCN1	5.39e-04	14	86	2	29107716
Pubmed	SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.	SEC63 RRM1 TRRAP	5.45e-04	64	86	3	26511642
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	INTS2 KDM3B PDCD11 TRRAP GCN1	5.86e-04	272	86	5	31010829
Pubmed	Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation.	HCN4 HCN1	6.21e-04	15	86	2	21147989
Pubmed	Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.	HCN4 ZFPM2	6.21e-04	15	86	2	28195173
Pubmed	Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.	AP2A1 MYO1C SEC63	6.24e-04	67	86	3	29357390
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	INTS2 UBR5 CHD8 GCN1 ARMC8	6.90e-04	282	86	5	23667531
Pubmed	Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.	P2RY12 HTT	7.09e-04	16	86	2	27721240
Pubmed	Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.	NEK1 PLK4	7.09e-04	16	86	2	8274451
Pubmed	Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.	CHD8 TRRAP	8.02e-04	17	86	2	21653943
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	8.02e-04	17	86	2	20856818
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	SATB1 AP2A1 AK5 HCN1 TRRAP PHGDH HTT	8.89e-04	621	86	7	22794259
Pubmed	USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.	CHD8 TRRAP	9.01e-04	18	86	2	17846119
Pubmed	Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21.	COL6A2 ACY1	9.01e-04	18	86	2	1783381
Pubmed	The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.	PCSK1 MYT1	9.01e-04	18	86	2	17537793
Pubmed	Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.	HCN4 HCN1	9.01e-04	18	86	2	27180262
Pubmed	Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors.	SCN11A P2RX3	1.01e-03	19	86	2	22787056
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	UBR5 CHD8 GCN1	1.01e-03	79	86	3	26446488
Pubmed	The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue.	SPR AK5 AGTPBP1	1.01e-03	79	86	3	25921334
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	AP2A1 GCN1 PHGDH ARMC8	1.13e-03	183	86	4	23956138
Pubmed	Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit.	HCN4 ZFPM2	1.23e-03	21	86	2	28302382
Pubmed	ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.	SCN11A P2RX3	1.23e-03	21	86	2	25369838
Pubmed	Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.	HCN4 HCN1	1.23e-03	21	86	2	30270038
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	INTS2 UBR5 SEC63 CADPS2 GCN1 PHGDH ERLIN1	1.23e-03	657	86	7	36180527
Pubmed	HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.	GCN1 POLR3A ARMC8	1.33e-03	87	86	3	33711283
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	COL6A2 CEP126	1.35e-03	22	86	2	12812986
Pubmed	FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.	HCN1 ACY1	1.35e-03	22	86	2	26494785
Pubmed	Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.	SCN11A P2RX3	1.48e-03	23	86	2	20096094
Pubmed	Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.	SCN11A P2RX3	1.48e-03	23	86	2	16446141
Pubmed	BDNF and NT4 play interchangeable roles in gustatory development.	P2RX3 CD44	1.48e-03	23	86	2	24378336
Pubmed	Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.	CADPS2 GCN1 ERLIN1 POLR3A	1.50e-03	198	86	4	24337577
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	AP2A1 CD44 CEP126 SEC63 GCN1 ERLIN1	1.51e-03	499	86	6	22810586
Pubmed	Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice.	GET1 RRM1	1.61e-03	24	86	2	26178733
Pubmed	P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.	UBR5 TRRAP	1.75e-03	25	86	2	36708875
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	UBR5 HERC1	1.89e-03	26	86	2	26949039
Pubmed	Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.	MYO1C ARMC8	1.89e-03	26	86	2	28720576
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	UBR5 KDM3B CHD8 GCN1 PHGDH	1.96e-03	357	86	5	37059091
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KIAA0825 UBR5 MYT1	1.99e-03	100	86	3	10048485
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	AP2A1 GCN1 AGTPBP1 POLR3A	2.03e-03	215	86	4	35973513
GeneFamily	Cyclic nucleotide gated channels	HCN4 HCN1	3.19e-04	10	49	2	250
ToppCell	ileum-Epithelial_Stem_Cells\|ileum / shred on tissue and cell subclass	PCSK1 COL6A2 PDCD11 SYBU RRM1	4.62e-06	126	86	5	a8ed48cbd1e207fd1aaad454fda9f329eb22aa83
ToppCell	facs-Heart-RA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCRL1 P2RX3 SATB1 DDX25 LAPTM5	1.76e-05	166	86	5	fc2cf67311c86fda75b35fcd4768b6f6f14c59d0
ToppCell	facs-Heart-RA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCRL1 P2RX3 SATB1 DDX25 LAPTM5	1.76e-05	166	86	5	33a6876d06e26176135a73a77c19e634ec53f7ce
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MROH9 LRRIQ1 KIAA0825 HCN4 CEP126	1.92e-05	169	86	5	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCRL1 KCNA3 SATB1 DDX25 LAPTM5	2.46e-05	178	86	5	ba5a477257877f4a15a91c1762ffcc6f2e9f7357
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCRL1 KCNA3 SATB1 DDX25 LAPTM5	2.46e-05	178	86	5	5634c1fbc817758092af4feafff94d107412d89b
ToppCell	facs-Spleen-nan-3m-Lymphocytic-CD79a_B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD9L FCRL1 MYO1C P2RY12 KMO	3.12e-05	187	86	5	b51af2824e65734f333b1325117f4a2e88b17c23
ToppCell	facs-Spleen-nan-3m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD9L FCRL1 MYO1C P2RY12 KMO	3.12e-05	187	86	5	3ca3954f45f167e98a230f2847f0582d74fcd32e
ToppCell	(04)_Pre-ciliated\|World / shred by cell type and Timepoint	AK5 CFAP206 RRM1 PLK4 ERLIN1	3.45e-05	191	86	5	37cf121e6e80760c8519075b7845b9029958a988
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	MROH9 LRRIQ1 KIAA0825 CFAP206 CEP126	3.62e-05	193	86	5	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MROH9 KIAA0825 LINC00862 CFAP206 PLK4	4.00e-05	197	86	5	6e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SAMD9L FCRL1 OVCH1 KMO LAPTM5	4.09e-05	198	86	5	e125eb8aa57c172e5518874da1bd25998292f5e2
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SAMD9L FCRL1 OVCH1 KMO LAPTM5	4.09e-05	198	86	5	0baeb8e2c199ff10bb5c829c523546af3c9227c1
ToppCell	390C-Myeloid-Dendritic-cDC2\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	SATB1 CD44 MAP2K3 KMO LAPTM5	4.09e-05	198	86	5	8b28e6630dcffa7ca32e959a50f94a0370b78ae0
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	7.63e-06	2	82	2	DOID:0110471 (implicated_via_orthology)
Disease	sick sinus syndrome (implicated_via_orthology)	HCN4 HCN1	2.28e-05	3	82	2	DOID:13884 (implicated_via_orthology)
Disease	pleckstrin homology domain-containing family A member 1 measurement	BTBD16 ZFPM2	1.59e-04	7	82	2	EFO_0802873
Disease	Intellectual Disability	SPR ASAH1 KDM3B CHD8 ACY1 TRRAP HTT	2.50e-04	447	82	7	C3714756
Disease	gastric adenocarcinoma (is_implicated_in)	UBR5 CD44	4.13e-04	11	82	2	DOID:3717 (is_implicated_in)
Disease	colon cancer (is_marker_for)	UBR5 MAP2K3 PLK4	6.01e-04	59	82	3	DOID:219 (is_marker_for)
Disease	sulfate measurement	CADPS2 HTT	6.79e-04	14	82	2	EFO_0007864
Disease	Paroxysmal atrial fibrillation	MYO1C HCN4 ASAH1 HERC1	9.54e-04	156	82	4	C0235480
Disease	familial atrial fibrillation	MYO1C HCN4 ASAH1 HERC1	9.54e-04	156	82	4	C3468561
Disease	Persistent atrial fibrillation	MYO1C HCN4 ASAH1 HERC1	9.54e-04	156	82	4	C2585653
Disease	Atrial Fibrillation	MYO1C HCN4 ASAH1 HERC1	1.05e-03	160	82	4	C0004238
Disease	anxiety disorder (implicated_via_orthology)	HCN1 KDM3B	1.70e-03	22	82	2	DOID:2030 (implicated_via_orthology)
Disease	insulin sensitivity measurement	PHGDH ARMC8	1.86e-03	23	82	2	EFO_0004471
Disease	visual epilepsy (biomarker_via_orthology)	PCSK1 HCN1 RRM1	2.04e-03	90	82	3	DOID:11832 (biomarker_via_orthology)
Disease	breast carcinoma	SATB1 LINC00862 TMEM69 HCN1 MYT1 RNF146 PHGDH ZFPM2 AGTPBP1	2.07e-03	1019	82	9	EFO_0000305
Disease	Dwarfism	KDM3B PLK4	2.20e-03	25	82	2	C0013336
Disease	Adenocarcinoma of lung (disorder)	NEK1 SATB1 RRM1 NPM3	2.64e-03	206	82	4	C0152013

Protein segments in the cluster

Peptide	Gene	Start	Entry
NTMRADPALCFLEKA	CHD8	1646	Q9HCK8
KQPFSGDLLSLSQMC	BTBD16	26	Q32M84
SNIPNMFVDSSCALK	ERLIN1	301	O75477
IKNDLASRNPTFMCL	AP2A1	116	O95782
PAKMCLNRTSQENIS	ASAH1	336	Q13510
ELCSLNPMSDKLTFS	DIS3L2	451	Q8IYB7
NTSSLIMRKCFPKNR	AGTPBP1	316	Q9UPW5
QRALPSECQMLLFSA	DDX25	266	Q9UHL0
CMTRLLDTKNPSLDT	CFAP206	66	Q8IYR0
KISCTDPSINFLMLF	OR5H8	186	P0DN80
TPLNFCLKSSNEESM	RAD9B	181	Q6WBX8
RLNPINTTLLKMADC	NDRG3	276	Q9UGV2
TMLPLALACRDDSFQ	KIAA0825	496	Q8IV33
DANNPKMLRTCSLPD	NEK1	1041	Q96PY6
LKLSCQPMLSLDDFQ	NPM3	101	O75607
PQLFESLLNGLMCSK	AK5	16	Q9Y6K8
CMLKLPSLDLVFSSN	KIAA1109	4066	Q2LD37
PQCTKSFSNARALEM	ZFPM2	301	Q8WW38
QLALAKMVCSDSPFA	HERC1	86	Q15751
PCTLSFTEMEKNNLL	F13B	581	P05160
RTDALRFLCKMNPSQ	INTS2	246	Q9H0H0
ACPSKATFSRNIMNL	KCNA3	316	P22001
LSKNLFFQCMSQTLP	KDM3B	521	Q7LBC6
ALCDSSTPLKFVSLM	LRRC2	301	Q9BYS8
LNSCLSPFLCLMASA	GPR152	286	Q8TDT2
FLSLAACVMPSRLKA	GCN1	901	Q92616
RNSLISMLKCPNSAT	P2RY12	306	Q9H244
IPSLLKLSCSDTSMN	OR5J2	181	Q8NH18
RFSLDITNLMPLAAC	MROH9	386	Q5TGP6
CRKLVASMPLFANAD	HCN4	586	Q9Y3Q4
SSRNMKCNHFLPELD	LRRIQ1	1646	Q96JM4
FIFRKNLPSTALCQM	NDOR1	76	Q9UHB4
ASSMLCNLLLEFSPS	ARMC8	446	Q8IUR7
MNSEFNLSLLAPCLS	HTT	2136	P42858
CRKLVATMPLFANAD	HCN1	466	O60741
MDKFSNDLSLCLPVF	KMO	331	O15229
MLNFNEKCTRSPLLT	BSPRY	201	Q5W0U4
DLCKAFNSTLPTMAQ	CD44	51	P16070
LTCKMPFLQSSDAQF	FCRL1	36	Q96LA6
ISLKPANMQSTNLSC	CEP126	281	Q9P2H0
AQLPFLTMCLKESLR	CYP4F8	376	P98187
ACDKPQQVRNMTLFS	COL6A2	776	P12110
QPMSLKLTCSAFRLQ	GDF5-AS1	6	Q5U4N7
CNVLRILLPSFSSFM	GET1	21	O00258
PNLSCMFALLLADRS	C1orf112	691	Q9NSG2
DLCKQPNRMALSAVS	CADPS2	216	Q86UW7
LAQMRRISPFSCLKD	IFNA8	41	P32881
SSFLLSDISCMQPLL	METTL4	261	Q8N3J2
PAHSFVCSLSLKMNR	FPGT	461	O14772
IPKDLHFRNTMLSSC	HEXA-AS1	96	Q9H8Q6
LLPNLTARDMKTCRF	P2RX3	191	P56373
FTAQCLRKNPAERMS	MAP2K3	301	P46734
NSLDFSSCMLRPGIK	SYNRG	1226	Q9UMZ2
SSKFPLMTLQLLDFC	LAPTM5	131	Q13571
ILNCMRSRNPDESAK	SAMD9L	836	Q8IVG5
DRACNTVLKSMNLPP	OVCH1	201	Q7RTY7
KDLLRTMPSNACFAS	SGSM3	161	Q96HU1
ACLRELDKSNSPLTM	POLR3A	766	O14802
ILSLKMSLQQNFSPC	TMEM69	31	Q5SWH9
KSPAQLFCRMSVDLA	LINC00862	71	A6NCI5
SINMLPTNRKANESC	RNF146	11	Q9NTX7
TKQLRAANPIDSMLC	PXYLP1	286	Q8TE99
SARNFNLPMCKAAET	OXCT1	226	P55809
ALSCFPEAMSKRQTA	PRAMEF2	121	O60811
KLQCLSSILLMFSNP	PLK4	951	O00444
RILKSQNNSSVDPCM	SP140L	386	Q9H930
FLLGMLSQLPRCQSS	STRC	596	Q7RTU9
NQSSLAKECPLSQSM	SATB1	201	Q01826
ASLVPTCNAMSRKLD	ARNTL	96	O00327
AFSRVCKDMNLTLEP	ACY1	326	Q03154
VLNCEPSKERMLLSF	PDCD11	596	Q14690
LCRKSLMCNLDFTPN	ZNF815P	76	A8K554
NRPQLSSCFLLSMKD	RRM1	211	P23921
EKDLLSMLCRNQLSP	SYBU	201	Q9NX95
MLCLTSSVLKAFPDS	SPR	131	P35270
RAPTLASLENCMKLS	SEC63	356	Q9UGP8
LLSMDHFTQPAKLCS	RRN3P2	316	A6NIE6
MFNRCTDLAPLSQKF	ZNF630	161	Q2M218
LLSPMLRSKESCNSS	SCN11A	1556	Q9UI33
MFTSSFCKNDVLPLS	SGTB	61	Q96EQ0
CLARQIPQATASMKD	PHGDH	116	O43175
FLLGMLSQLPRCQSS	STRCP1	596	A6NGW2
SMPENSQASRKDICL	TIGD7	186	Q6NT04
LPSSIQTMSCKLLLN	TRRAP	411	Q9Y4A5
ILSQMNPSLSPRLCK	ZAR1L	71	A6NP61
SCRFQLRSPESLKNM	UBR5	571	O95071
LFRNLKETMCSSKNP	MYO1C	566	O00159
LSGCPLADKSLRNLM	MYT1	821	Q01538
AMLRLLQSAFSKNSP	PCSK1	666	P29120