Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	RCC1	ALS2 HERC1	6.35e-04	20	35	2	PF00415
Domain	RCC1_3	ALS2 HERC1	7.01e-04	21	35	2	PS50012
Domain	RCC1_1	ALS2 HERC1	7.01e-04	21	35	2	PS00625
Domain	RCC1_2	ALS2 HERC1	7.01e-04	21	35	2	PS00626
Domain	Reg_chr_condens	ALS2 HERC1	7.70e-04	22	35	2	IPR000408
Domain	-	ALS2 HERC1	7.70e-04	22	35	2	2.130.10.30
Domain	RCC1/BLIP-II	ALS2 HERC1	8.42e-04	23	35	2	IPR009091
Domain	HECT	HUWE1 HERC1	1.16e-03	27	35	2	PF00632
Domain	HECTc	HUWE1 HERC1	1.16e-03	27	35	2	SM00119
Domain	HECT_dom	HUWE1 HERC1	1.16e-03	27	35	2	IPR000569
Domain	HECT	HUWE1 HERC1	1.16e-03	27	35	2	PS50237
Domain	WD40_repeat_CS	HERC1 COPA STRAP	3.54e-03	164	35	3	IPR019775
Domain	RhoGAP	GMIP ARHGAP23	6.01e-03	62	35	2	SM00324
Domain	RhoGAP	GMIP ARHGAP23	6.20e-03	63	35	2	PF00620
Domain	RHOGAP	GMIP ARHGAP23	6.39e-03	64	35	2	PS50238
Domain	RhoGAP_dom	GMIP ARHGAP23	6.39e-03	64	35	2	IPR000198
Domain	-	GMIP ARHGAP23	6.39e-03	64	35	2	1.10.555.10
Pubmed	Cloning and characterization of Ehox, a novel homeobox gene essential for embryonic stem cell differentiation.	RHOXF2B RHOXF2	1.10e-06	2	37	2	12087094
Pubmed	Rhox homeobox gene cluster: recent duplication of three family members.	RHOXF2B RHOXF2	1.10e-06	2	37	2	16496311
Pubmed	Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X.	RHOXF2B RHOXF2	1.10e-06	2	37	2	16465597
Pubmed	Cloning and characterization of the 5'-flanking region of the Ehox gene.	RHOXF2B RHOXF2	1.10e-06	2	37	2	16414020
Pubmed	DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner.	RHOXF2B RHOXF2 DNMT3A	2.21e-06	24	37	3	17182866
Pubmed	The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c.	RHOXF2B RHOXF2	3.30e-06	3	37	2	18077458
Pubmed	The rhox homeobox gene family shows sexually dimorphic and dynamic expression during mouse embryonic gonad development.	RHOXF2B RHOXF2	3.30e-06	3	37	2	18562707
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	TM2D3 GALNT2 EDEM1 COPA STRAP CSGALNACT1 VKORC1L1 DGAT1 SMAD2	3.52e-06	1201	37	9	35696571
Pubmed	Maternal DNA Methylation Regulates Early Trophoblast Development.	RHOXF2B RHOXF2 DNMT3A	3.56e-06	28	37	3	26812015
Pubmed	Rhox: a new homeobox gene cluster.	RHOXF2B RHOXF2	6.60e-06	4	37	2	15707895
Pubmed	Expression of a novel homeobox gene Ehox in trophoblast stem cells and pharyngeal pouch endoderm.	RHOXF2B RHOXF2	1.10e-05	5	37	2	14648851
Pubmed	Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.	STRAP SMAD2	2.30e-05	7	37	2	15761148
Pubmed	STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling.	STRAP SMAD2	2.30e-05	7	37	2	10757800
Pubmed	Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development.	RHOXF2B RHOXF2	4.93e-05	10	37	2	21972064
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	HUWE1 GALNT2 COPA GFPT1 VKORC1L1 DNAJC11 NUP88	5.29e-05	942	37	7	31073040
Pubmed	Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner.	THBS4 SMAD2	6.02e-05	11	37	2	38678560
Pubmed	A major X-linked locus affects kidney function in mice.	RHOXF2B RHOXF2	7.22e-05	12	37	2	23011808
Pubmed	Transcriptomic analysis of mouse limb tendon cells during development.	THBS4 SMAD2	7.22e-05	12	37	2	25249460
Pubmed	Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice.	RHOXF2B RHOXF2	7.22e-05	12	37	2	29500366
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	HERC1 EDEM1 COPA STRAP	1.05e-04	231	37	4	36597993
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	THBS4 HUWE1 MDN1 GFPT1 CABLES1 PPIL6	1.17e-04	736	37	6	29676528
Pubmed	Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.	HUWE1 COPA GFPT1 DNAJC11	1.30e-04	244	37	4	28902428
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	TM2D3 MDN1 GALNT2 SMAD2 DNAJC11 NUP88	1.33e-04	754	37	6	33060197
Pubmed	Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.	SHROOM3 HUWE1 COPA GFPT1	1.41e-04	249	37	4	30097533
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	MDN1 COPA GTPBP10 GADL1 NUP88	1.54e-04	484	37	5	31995728
Pubmed	ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis.	RHOXF2B RHOXF2	1.67e-04	18	37	2	33842485
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	HUWE1 COPA GFPT1 CABLES1 NUP88	1.85e-04	503	37	5	16964243
Pubmed	Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor.	FIGLA PKHD1L1	1.86e-04	19	37	2	17567914
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	HUWE1 HERC1 COPA GFPT1	1.94e-04	271	37	4	25737280
Pubmed	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	TM2D3 MDN1 DNAJC11 NUP88	2.79e-04	298	37	4	32353859
Pubmed	FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.	HUWE1 HERC1 STRAP	3.45e-04	128	37	3	28027390
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HUWE1 HERC1	3.52e-04	26	37	2	26949039
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TM2D3 RIPK4 HUWE1 GALNT2 COPA GFPT1 SMAD2	3.60e-04	1285	37	7	35914814
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ALS2 HUWE1 GMIP COPA ARHGAP23 DNAJC11	3.80e-04	916	37	6	32203420
Pubmed	Specification of jaw identity by the Hand2 transcription factor.	RHOXF2B RHOXF2	4.09e-04	28	37	2	27329940
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	HUWE1 MDN1 COPA STRAP	4.20e-04	332	37	4	32786267
Pubmed	Proteomic analysis of the NOS2 interactome in human airway epithelial cells.	HUWE1 HERC1 STRAP	4.30e-04	138	37	3	23438482
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	HUWE1 MDN1 STRAP DNAJC11 NUP88	4.34e-04	606	37	5	36538041
Pubmed	Many sequence variants affecting diversity of adult human height.	CABLES1 DNMT3A PPIL6	4.77e-04	143	37	3	18391951
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	HUWE1 MDN1 COPA STRAP	4.80e-04	344	37	4	30333137
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	HUWE1 EDEM1 GFPT1 SMAD2 DNAJC11 NUP88	5.26e-04	974	37	6	28675297
Pubmed	GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles.	GALNT2 COPA	5.35e-04	32	37	2	34473204
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	HUWE1 MDN1 COPA STRAP GFPT1	5.84e-04	647	37	5	26618866
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ALS2 MDN1 GFPT1 VKORC1L1	5.87e-04	363	37	4	14691545
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	HUWE1 MDN1 COPA GFPT1 NUP88	6.09e-04	653	37	5	22586326
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	HUWE1 MDN1 COPA STRAP GFPT1 DNAJC11 NUP88	6.68e-04	1425	37	7	30948266
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	HUWE1 MDN1 HERC1 STRAP CSGALNACT1 VKORC1L1	8.22e-04	1061	37	6	33845483
Pubmed	O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components.	GALNT2 EDEM1	8.37e-04	40	37	2	22643896
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	HUWE1 COPA GFPT1 SMAD2 NUP88	8.54e-04	704	37	5	29955894
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	HUWE1 COPA STRAP DNAJC11	9.08e-04	408	37	4	33766124
Pubmed	Proteomic identification of brain proteins that interact with dynein light chain LC8.	SHROOM3 DNMT3A	9.23e-04	42	37	2	14760703
Pubmed	The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development.	EDEM1 SMAD2	9.23e-04	42	37	2	26816051
Pubmed	Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.	HUWE1 COPA	9.23e-04	42	37	2	27578003
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	MDN1 COPA STRAP GFPT1 DNAJC11	9.74e-04	725	37	5	27025967
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	HUWE1 GALNT2 COPA STRAP	9.93e-04	418	37	4	35338135
Cytoband	Xq24	RHOXF2B RHOXF2	1.23e-03	64	37	2	Xq24
Cytoband	Ensembl 112 genes in cytogenetic band chrXq24	RHOXF2B RHOXF2	1.97e-03	81	37	2	chrXq24
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	GMIP ARHGAP23	1.67e-03	50	22	2	721
GeneFamily	WD repeat domain containing	HERC1 COPA STRAP	3.78e-03	262	22	3	362
GeneFamily	PRD class homeoboxes and pseudogenes	RHOXF2B RHOXF2	5.54e-03	92	22	2	521
Disease	triglyceride measurement, intermediate density lipoprotein measurement	SHROOM3 GALNT2 CSGALNACT1	2.85e-04	111	34	3	EFO_0004530, EFO_0008595
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	SHROOM3 GALNT2 CSGALNACT1	3.67e-04	121	34	3	EFO_0008595, EFO_0020943
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	SHROOM3 GALNT2 CSGALNACT1	4.23e-04	127	34	3	EFO_0008595, EFO_0020947
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	SHROOM3 GALNT2 CSGALNACT1	6.86e-04	150	34	3	EFO_0004611, EFO_0020947
Disease	platelet-to-lymphocyte ratio	GALNT2 ITGAL CABLES1 DNMT3A	7.81e-04	363	34	4	EFO_0008446
Disease	Neoplasm Recurrence, Local	IDO1 DNMT3A	9.30e-04	39	34	2	C0027643
Disease	Acute Promyelocytic Leukemia	ITGAL DNMT3A	1.29e-03	46	34	2	C0023487
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	SHROOM3 GALNT2 CSGALNACT1	1.57e-03	200	34	3	EFO_0004611, EFO_0020945
Disease	polyunsaturated fatty acids to monounsaturated fatty acids ratio	GALNT2 CSGALNACT1	1.59e-03	51	34	2	EFO_0022302
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	SHROOM3 GALNT2 CSGALNACT1	2.12e-03	222	34	3	EFO_0008317, EFO_0020943
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	SHROOM3 GALNT2 CSGALNACT1	2.17e-03	224	34	3	EFO_0004530, EFO_0008317

Protein segments in the cluster

Peptide	Gene	Start	Entry
IGGFDLDIKGWGGED	CSGALNACT1	436	Q8TDX6
DGRGFGIGELVWGKL	DNMT3A	286	Q9Y6K1
WGKGKEGQLGHGDVL	ALS2	531	Q96Q42
PNKDGDAGVGSGHWE	DGAT1	51	O75907
KGWGELEFGAGDLQG	DNAJC11	206	Q9NVH1
GFWEDPKEFAGGSAG	IDO1	251	P14902
ADLPVEGGKGGEFAW	MDN1	1791	Q9NU22
EGGKGGEFAWRDGPL	MDN1	1796	Q9NU22
GDGLENGLGSPFGKW	GMIP	471	Q9P107
AGGEEGGAAGLWVKS	KCNQ5	6	Q9NR82
GGGAGRKEDWNEIDP	GALNT2	36	Q10471
GEVFSWGDGDYGKLG	HERC1	4101	Q15751
WGDGDYGKLGHGNSD	HERC1	4106	Q15751
GKGLEWMGGFDPEDG	IGHV1-24	61	A0A0C4DH33
GAGGPEGKAVAGAWE	LBHD2	16	A0A0U1RRK4
WIQGGDIVYGKGDNG	PPIL6	206	Q8IXY8
LAESWGGKENGFGLA	HUWE1	166	Q7Z6Z7
GGEGGKGGDVWVVAQ	GTPBP10	36	A4D1E9
QDAEWGGGEEGGAAK	CABLES1	81	Q8TDN4
GDDALGKGQEEGGGW	COPA	866	P53621
GHWVGKQSGLGAGLD	EDEM1	356	Q92611
LKNEEEGPWADGGSG	FIGLA	166	Q6QHK4
FIGWKEGDGIFNPGG	GADL1	166	Q6ZQY3
VFGLGGELFLWDGED	NUP88	61	Q99567
DSAGVGFDGGNDKDW	GFPT1	36	Q06210
FLEGGAPWGFTLKGG	SHROOM3	31	Q8TF72
EEKDGGGAGVPGHLW	RHOXF2B	76	P0C7M4
GAVGAKDWAGGFLDL	ITGAL	366	P20701
EFTGWEKVGSGGFGQ	RIPK4	21	P57078
GDTGDWIGTFLGHKG	STRAP	46	Q9Y3F4
GVGWAGDGYICGKDV	THBS4	451	P35443
NITAWGGEFGKEGEG	nan	16	Q9BRP9
GWGEVINGGFGLVLD	UROC1	596	Q96N76
GGAGGGEQNGQEEKW	SMAD2	26	Q15796
DLNFNEWKELGGGGP	ARHGAP23	1416	Q9P227
EEKDGGGAGVPGHLW	RHOXF2	76	Q9BQY4
GRLIGGWEDNPFKGD	PKHD1L1	3111	Q86WI1
WGRGFGLLGSIFGKD	VKORC1L1	66	Q8N0U8
EGLGKLFSFGGLGIW	TM2D3	211	Q9BRN9
GGQDLQLEGGALGSW	ZFTA	46	C9JLR9