Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ornithine decarboxylase activity	AZIN2 ODC1	9.23e-05	4	79	2	GO:0004586
GeneOntologyMolecularFunction	serine-type peptidase activity	PRSS1 PRSS16 PCSK7 MMP9 KLK3 KLK2	1.71e-04	207	79	6	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	PRSS1 PRSS16 PCSK7 MMP9 KLK3 KLK2	1.95e-04	212	79	6	GO:0017171
GeneOntologyBiologicalProcess	tissue kallikrein-kinin cascade	KLK3 KLK2	4.45e-05	3	80	2	GO:0002255
GeneOntologyBiologicalProcess	putrescine biosynthetic process from ornithine	AZIN2 ODC1	8.87e-05	4	80	2	GO:0033387
GeneOntologyBiologicalProcess	bradykinin biosynthetic process	KLK3 KLK2	8.87e-05	4	80	2	GO:0002936
Domain	De-COase2_pyr-phos_BS	AZIN2 ODC1	1.68e-05	2	77	2	IPR022653
Domain	-	MRC1 MRC2 MMP9	1.87e-05	13	77	3	2.10.10.10
Domain	FN_type2_col-bd	MRC1 MRC2 MMP9	2.37e-05	14	77	3	IPR000562
Domain	FN2_2	MRC1 MRC2 MMP9	2.37e-05	14	77	3	PS51092
Domain	fn2	MRC1 MRC2 MMP9	2.37e-05	14	77	3	PF00040
Domain	FN2_1	MRC1 MRC2 MMP9	2.37e-05	14	77	3	PS00023
Domain	FN2	MRC1 MRC2 MMP9	2.37e-05	14	77	3	SM00059
Domain	Orn_de-COase	AZIN2 ODC1	5.02e-05	3	77	2	IPR002433
Domain	-	AZIN2 ODC1	5.02e-05	3	77	2	2.40.37.10
Domain	Ala_racemase/Decarboxylase_C	AZIN2 ODC1	5.02e-05	3	77	2	IPR009006
Domain	Orn_Arg_deC_N	AZIN2 ODC1	5.02e-05	3	77	2	PF02784
Domain	De-COase2_CS	AZIN2 ODC1	5.02e-05	3	77	2	IPR022657
Domain	De-COase2_N	AZIN2 ODC1	5.02e-05	3	77	2	IPR022644
Domain	De-COase2_C	AZIN2 ODC1	5.02e-05	3	77	2	IPR022643
Domain	ODR_DC_2_1	AZIN2 ODC1	5.02e-05	3	77	2	PS00878
Domain	ODR_DC_2_2	AZIN2 ODC1	5.02e-05	3	77	2	PS00879
Domain	Orn_DAP_Arg_deC	AZIN2 ODC1	5.02e-05	3	77	2	PF00278
Domain	Orn/DAP/Arg_de-COase	AZIN2 ODC1	5.02e-05	3	77	2	IPR000183
Domain	-	AZIN2 ODC1	1.00e-04	4	77	2	3.20.20.10
Domain	PLP-binding_barrel	AZIN2 ODC1	1.00e-04	4	77	2	IPR029066
Domain	Kringle-like	MRC1 MRC2 MMP9	3.07e-04	32	77	3	IPR013806
Domain	GPS	ADGRD2 ADGRF3 ADGRE1	3.68e-04	34	77	3	SM00303
Domain	GPS	ADGRD2 ADGRF3 ADGRE1	4.01e-04	35	77	3	PF01825
Domain	GPS	ADGRD2 ADGRF3 ADGRE1	4.36e-04	36	77	3	PS50221
Domain	GPS	ADGRD2 ADGRF3 ADGRE1	4.73e-04	37	77	3	IPR000203
Domain	G_PROTEIN_RECEP_F2_2	ADGRD2 ADGRF3 ADGRE1	1.15e-03	50	77	3	PS00650
Domain	7tm_2	ADGRD2 ADGRF3 ADGRE1	1.15e-03	50	77	3	PF00002
Domain	-	PNLIP PRSS16 FAM135B TG	1.48e-03	119	77	4	3.40.50.1820
Domain	AB_hydrolase	PNLIP PRSS16 FAM135B TG	1.48e-03	119	77	4	IPR029058
Domain	GPCR_2_secretin-like	ADGRD2 ADGRF3 ADGRE1	1.95e-03	60	77	3	IPR000832
Domain	GPCR_2-like	ADGRD2 ADGRF3 ADGRE1	1.95e-03	60	77	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	ADGRD2 ADGRF3 ADGRE1	2.04e-03	61	77	3	PS50261
Domain	Ig-like_fold	LIFR LILRA3 PTPRG MYCBP2 TSPOAP1 SIGLEC8 PSG11 ALPK3 ADGRF3	2.43e-03	706	77	9	IPR013783
Domain	RCC1	RCC1L MYCBP2	3.04e-03	20	77	2	PF00415
Domain	RCC1_1	RCC1L MYCBP2	3.35e-03	21	77	2	PS00625
Domain	RCC1_2	RCC1L MYCBP2	3.35e-03	21	77	2	PS00626
Domain	RCC1_3	RCC1L MYCBP2	3.35e-03	21	77	2	PS50012
Domain	-	MYCBP2 PCSK7 F5	3.41e-03	73	77	3	2.60.120.260
Domain	Reg_chr_condens	RCC1L MYCBP2	3.67e-03	22	77	2	IPR000408
Domain	-	RCC1L MYCBP2	3.67e-03	22	77	2	2.130.10.30
Domain	RCC1/BLIP-II	RCC1L MYCBP2	4.01e-03	23	77	2	IPR009091
Domain	C_TYPE_LECTIN_1	MRC1 CHODL MRC2	4.41e-03	80	77	3	PS00615
Domain	Ricin_B_lectin	MRC1 MRC2	4.73e-03	25	77	2	PF00652
Domain	Lectin_C	MRC1 CHODL MRC2	5.05e-03	84	77	3	PF00059
Domain	CLECT	MRC1 CHODL MRC2	5.05e-03	84	77	3	SM00034
Domain	C_TYPE_LECTIN_2	MRC1 CHODL MRC2	5.22e-03	85	77	3	PS50041
Domain	C-type_lectin-like	MRC1 CHODL MRC2	5.39e-03	86	77	3	IPR001304
Domain	-	LIFR LILRA3 PTPRG MYCBP2 TSPOAP1 SIGLEC8 PSG11 ALPK3	5.90e-03	663	77	8	2.60.40.10
Domain	RICIN	MRC1 MRC2	5.92e-03	28	77	2	SM00458
Domain	RICIN_B_LECTIN	MRC1 MRC2	5.92e-03	28	77	2	PS50231
Domain	TRYPSIN_SER	PRSS1 KLK3 KLK2	6.12e-03	90	77	3	IPR033116
Domain	Ricin_B_lectin	MRC1 MRC2	6.77e-03	30	77	2	IPR000772
Domain	Galactose-bd-like	MYCBP2 PCSK7 F5	6.90e-03	94	77	3	IPR008979
Domain	-	MRC1 CHODL MRC2	7.53e-03	97	77	3	3.10.100.10
Domain	C-type_lectin-like/link	MRC1 CHODL MRC2	7.96e-03	99	77	3	IPR016186
Pathway	REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES	PRSS1 MMP9 KLK3 KLK2	1.20e-05	38	53	4	MM14611
Pubmed	Distribution of murine mannose receptor expression from early embryogenesis through to adulthood.	MRC1 MRC2 ADGRE1	1.17e-08	3	80	3	9560474
Pubmed	HIV gp120 binds to mannose receptor on vaginal epithelial cells and induces production of matrix metalloproteinases.	MRC1 MRC2 MMP9	1.17e-08	3	80	3	22132194
Pubmed	Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men.	KLK3 KLK2	5.23e-06	2	80	2	24270797
Pubmed	Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1.	MRC1 MRC2	5.23e-06	2	80	2	19224860
Pubmed	The predictive value of prostate cancer biomarkers depends on age and time to diagnosis: towards a biologically-based screening strategy.	KLK3 KLK2	5.23e-06	2	80	2	17657743
Pubmed	Evaluation of molecular forms of prostate-specific antigen and human kallikrein 2 in predicting biochemical failure after radical prostatectomy.	KLK3 KLK2	5.23e-06	2	80	2	19003994
Pubmed	Mannose receptor regulation of macrophage cell migration.	MRC1 MRC2	5.23e-06	2	80	2	17596337
Pubmed	Association of human mannose receptor in sexual transmission of human immunodeficiency virus in serodiscordant couples.	MRC1 MRC2	5.23e-06	2	80	2	23148569
Pubmed	Proteomic analysis of patient tissue reveals PSA protein in the stroma of benign prostatic hyperplasia.	KLK3 KLK2	5.23e-06	2	80	2	24711254
Pubmed	CD4-independent infection of astrocytes by human immunodeficiency virus type 1: requirement for the human mannose receptor.	MRC1 MRC2	5.23e-06	2	80	2	15047828
Pubmed	LPS-stimulated MUC5AC production involves Rac1-dependent MMP-9 secretion and activation in NCI-H292 cells.	MMP9 MUC5AC	5.23e-06	2	80	2	19501047
Pubmed	Collagen triple helix repeat containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells.	CTHRC1 MMP9	5.23e-06	2	80	2	24504172
Pubmed	Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor.	MRC1 MRC2	5.23e-06	2	80	2	17360361
Pubmed	Risk assessment for biochemical recurrence prior to radical prostatectomy: significant enhancement contributed by human glandular kallikrein 2 (hK2) and free prostate specific antigen (PSA) in men with moderate PSA-elevation in serum.	KLK3 KLK2	5.23e-06	2	80	2	16152616
Pubmed	Ethnic variation in kallikrein expression in nipple aspirate fluid.	KLK3 KLK2	5.23e-06	2	80	2	12209605
Pubmed	Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins.	KLK3 KLK2	5.23e-06	2	80	2	11834722
Pubmed	Detection of prostate specific transcripts in the peripheral blood during brachytherapy predicts postoperative PSA kinetics.	KLK3 KLK2	5.23e-06	2	80	2	19434652
Pubmed	Regulation of high glucose-mediated mucin expression by matrix metalloproteinase-9 in human airway epithelial cells.	MMP9 MUC5AC	5.23e-06	2	80	2	25704757
Pubmed	Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients.	CUBN MMP9	5.23e-06	2	80	2	30557881
Pubmed	Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease.	AZIN2 ODC1	5.23e-06	2	80	2	19832840
Pubmed	HIV-1 Tat represses transcription from the mannose receptor promoter.	MRC1 MRC2	5.23e-06	2	80	2	11120831
Pubmed	The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor.	MRC1 MRC2	5.23e-06	2	80	2	17518370
Pubmed	Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation.	MMP9 MUC5AC	5.23e-06	2	80	2	15531749
Pubmed	Early prediction of prostate cancer biochemical recurrence and identification of disease persistence using PSA isoforms and human kallikrein-2.	KLK3 KLK2	5.23e-06	2	80	2	34486998
Pubmed	Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin.	KLK3 KLK2	5.23e-06	2	80	2	17593395
Pubmed	Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity.	AZIN2 ODC1	5.23e-06	2	80	2	16916800
Pubmed	Predictive value of four kallikrein markers for pathologically insignificant compared with aggressive prostate cancer in radical prostatectomy specimens: results from the European Randomized Study of Screening for Prostate Cancer section Rotterdam.	KLK3 KLK2	5.23e-06	2	80	2	23683475
Pubmed	Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin.	MRC1 MMP9 ADGRE1	5.23e-06	15	80	3	34721382
Pubmed	Mouse microsatellites from a flow-sorted 4:6 Robertsonian chromosome.	KLK3 KLK2 CHRNB1	1.11e-05	19	80	3	1450512
Pubmed	Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization.	KLK3 KLK2	1.57e-05	3	80	2	19164804
Pubmed	Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium.	KLK3 KLK2	1.57e-05	3	80	2	17465807
Pubmed	Mouse kallikrein arginyl-esteropeptidase genes: analysis of cloned cDNAs suggests rapid functional divergence from a common ancestral sequence.	KLK3 KLK2	1.57e-05	3	80	2	6926406
Pubmed	7S Nerve growth factor alpha and gamma subunits are closely related proteins.	KLK3 KLK2	1.57e-05	3	80	2	6712944
Pubmed	Tissue kallikrein is essential for invasive capacity of circulating proangiogenic cells.	KLK3 KLK2	1.57e-05	3	80	2	21164105
Pubmed	Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5.	KLK3 KLK2	1.57e-05	3	80	2	17006539
Pubmed	Characterization of mouse glandular kallikrein 24 expressed in testicular Leydig cells.	KLK3 KLK2	1.57e-05	3	80	2	15985384
Pubmed	Characterization of androgen receptor and nuclear receptor co-regulator expression in human breast cancer cell lines exhibiting differential regulation of kallikreins 2 and 3.	KLK3 KLK2	1.57e-05	3	80	2	12124798
Pubmed	Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis.	KLK3 KLK2	1.57e-05	3	80	2	17210241
Pubmed	Detection of a kallikrein in the mouse lactating mammary gland: a possible processing enzyme for the epidermal growth factor precursor.	KLK3 KLK2	1.57e-05	3	80	2	7525260
Pubmed	Identification of mK1, a true tissue (glandular) kallikrein of mouse submandibular gland: tissue distribution and a comparison of kinin-releasing activity with other submandibular kallikreins.	KLK3 KLK2	1.57e-05	3	80	2	8188620
Pubmed	Mouse testicular Leydig cells express Klk21, a tissue kallikrein that cleaves fibronectin and IGF-binding protein-3.	KLK3 KLK2	1.57e-05	3	80	2	11606460
Pubmed	The amino acid sequence of the gamma-subunit of mouse submaxillary gland 7 S nerve growth factor.	KLK3 KLK2	1.57e-05	3	80	2	7263706
Pubmed	A cytocidal tissue kallikrein isolated from mouse submandibular glands.	KLK3 KLK2	1.57e-05	3	80	2	2583286
Pubmed	Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.	MMP9 MUC5AC	1.57e-05	3	80	2	18006877
Pubmed	Inducible expression of kallikrein in renal tubular cells protects mice against spontaneous lupus nephritis.	KLK3 KLK2	1.57e-05	3	80	2	23280471
Pubmed	Mouse glandular kallikrein genes. Nucleotide sequence of cloned cDNA coding for a member of the kallikrein arginyl esteropeptidase group of serine proteases.	KLK3 KLK2	1.57e-05	3	80	2	6174512
Pubmed	Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines.	KLK3 KLK2	1.57e-05	3	80	2	18778305
Pubmed	Single-chain tissue-type plasminogen activator is a substrate of mouse glandular kallikrein 24.	KLK3 KLK2	1.57e-05	3	80	2	16286722
Pubmed	mGK-6-derived true tissue kallikrein is synthesized, processed, and targeted through a regulated secretory pathway in mouse pituitary AtT-20 cells.	KLK3 KLK2	1.57e-05	3	80	2	1639762
Pubmed	Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator of Systemic Metabolism.	KLK3 KLK2	1.57e-05	3	80	2	37358498
Pubmed	Deletion of kallikrein 1b5 (Klk1b5) has no impact on fertility in mice.	KLK3 KLK2	1.57e-05	3	80	2	30957940
Pubmed	Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation.	KLK3 KLK2	1.57e-05	3	80	2	25628066
Pubmed	Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease.	KLK3 KLK2	1.57e-05	3	80	2	15033932
Pubmed	CTHRC1 induces non-small cell lung cancer (NSCLC) invasion through upregulating MMP-7/MMP-9.	CTHRC1 MMP9	1.57e-05	3	80	2	29631554
Pubmed	Cellular basis for the differential response of mouse kallikrein genes to hormonal induction.	KLK3 KLK2	1.57e-05	3	80	2	3649290
Pubmed	Kallikrein-related peptidases.	KLK3 KLK2	1.57e-05	3	80	2	18344018
Pubmed	Positive selection shaped the convergent evolution of independently expanded kallikrein subfamilies expressed in mouse and rat saliva proteomes.	KLK3 KLK2	1.57e-05	3	80	2	21695125
Pubmed	Uterine artery structural and functional changes during pregnancy in tissue kallikrein-deficient mice.	KLK3 KLK2	1.57e-05	3	80	2	12933530
Pubmed	The lupus-susceptibility gene kallikrein downmodulates antibody-mediated glomerulonephritis.	KLK3 KLK2	1.57e-05	3	80	2	19262577
Pubmed	Renin and kallikrein in connecting tubule of mouse.	KLK3 KLK2	1.57e-05	3	80	2	14633138
Pubmed	Sequence of mGK-11, a mouse glandular kallikrein gene.	KLK3 KLK2	1.57e-05	3	80	2	3205728
Pubmed	Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides.	KLK3 KLK2	1.57e-05	3	80	2	6602295
Pubmed	A complete cDNA sequence for the major epidermal growth factor binding protein in the male mouse submandibular gland.	KLK3 KLK2	1.57e-05	3	80	2	3322386
Pubmed	HIV-1 interaction with human mannose receptor (hMR) induces production of matrix metalloproteinase 2 (MMP-2) through hMR-mediated intracellular signaling in astrocytes.	MRC1 MRC2	1.57e-05	3	80	2	15955449
Pubmed	beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22.	KLK3 KLK2	1.57e-05	3	80	2	2012805
Pubmed	Kallikrein protects against microalbuminuria in experimental type I diabetes.	KLK3 KLK2	1.57e-05	3	80	2	19516248
Pubmed	Autoimmunity against a tissue kallikrein in IQI/Jic Mice: a model for Sjogren's syndrome.	KLK3 KLK2	1.57e-05	3	80	2	15545270
Pubmed	Sequence and expression of mouse gamma-renin.	KLK3 KLK2	1.57e-05	3	80	2	3288617
Pubmed	Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.	MRC1 MRC2	1.57e-05	3	80	2	30366943
Pubmed	Sequence of an epidermal growth factor-binding protein.	KLK3 KLK2	1.57e-05	3	80	2	6330081
Pubmed	Cloning and characterization of mouse klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity.	KLK3 KLK2	1.57e-05	3	80	2	11082197
Pubmed	Mouse glandular kallikrein genes. Identification, structure, and expression of the renal kallikrein gene.	KLK3 KLK2	1.57e-05	3	80	2	3007510
Pubmed	Role of tissue kallikrein in response to flow in mouse resistance arteries.	KLK3 KLK2	1.57e-05	3	80	2	15126916
Pubmed	The molecular biology of the kallikrein-kinin system: I. General description, nomenclature and the mouse gene family.	KLK3 KLK2	1.57e-05	3	80	2	8228186
Pubmed	The sequence of a cDNA clone coding for a novel kallikrein from mouse submaxillary gland.	KLK3 KLK2	1.57e-05	3	80	2	3636812
Pubmed	Reduction in nerve growth factor availability leads to a conditioning lesion-like effect in sympathetic neurons.	KLK3 KLK2	1.57e-05	3	80	2	16967509
Pubmed	Growth factor-binding proteases in the murine submaxillary gland: isolation of a cDNA clone.	KLK3 KLK2	1.57e-05	3	80	2	11892812
Pubmed	Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice.	KLK3 KLK2	1.57e-05	3	80	2	11226291
Pubmed	Sequence of the mouse glandular kallikrein gene, mGK-5.	KLK3 KLK2	1.57e-05	3	80	2	3502721
Pubmed	Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis.	KLK3 KLK2	1.57e-05	3	80	2	22335454
Pubmed	CD147 increases mucus secretion induced by cigarette smoke in COPD.	MMP9 MUC5AC	1.57e-05	3	80	2	30727993
Pubmed	Isolation of a cDNA clone coding for the gamma-subunit of mouse nerve growth factor using a high-stringency selection procedure.	KLK3 KLK2	1.57e-05	3	80	2	6548955
Pubmed	Interference of kallikrein 1b26 (klk1b26) translation by microRNA specifically expressed in female mouse submandibular glands: an additional mechanism for sexual dimorphism of klk1b26 protein in the glands.	KLK3 KLK2	1.57e-05	3	80	2	22085651
Pubmed	Sites of glandular kallikrein gene expression in fetal mice.	KLK3 KLK2	1.57e-05	3	80	2	1334010
Pubmed	Tissue kallikrein deficiency and renovascular hypertension in the mouse.	KLK3 KLK2	1.57e-05	3	80	2	19244588
Pubmed	Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins.	KLK3 KLK2	1.57e-05	3	80	2	15040788
Pubmed	Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney.	KLK3 KLK2	1.57e-05	3	80	2	18627303
Pubmed	Tissue kallikrein is required for the cardioprotective effect of cyclosporin A in myocardial ischemia in the mouse.	KLK3 KLK2	1.57e-05	3	80	2	25623731
Pubmed	Estrogen-dependent expression of the tissue kallikrein gene (Klk1) in the mouse uterus and its implications for endometrial tissue growth.	KLK3 KLK2	1.57e-05	3	80	2	17219431
Pubmed	Analysis of androgen and anti-androgen regulation of KLK-related peptidase 2, 3, and 4 alternative transcripts in prostate cancer.	KLK3 KLK2	1.57e-05	3	80	2	25153393
Pubmed	A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.	KLK3 KLK2	1.57e-05	3	80	2	19823874
Pubmed	Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse.	KLK3 KLK2	1.57e-05	3	80	2	22669897
Pubmed	Genes for the alpha and gamma subunits of mouse nerve growth factor are contiguous.	KLK3 KLK2	1.57e-05	3	80	2	3848399
Pubmed	Temporal and tissue-specific expression of kallikrein (Klk) genes and identification of a novel Klk messenger ribonucleic acid transcript during early development in the mouse.	KLK3 KLK2	1.57e-05	3	80	2	10456837
Pubmed	Is there an inter-relationship between prostate specific antigen, kallikrein-2 and androgen receptor gene polymorphisms with risk of prostate cancer in north Indian population?	KLK3 KLK2	1.57e-05	3	80	2	17257635
Pubmed	Neuroprotective effect of kinin B1 receptor activation in acute cerebral ischemia in diabetic mice.	KLK3 KLK2	1.57e-05	3	80	2	28842604
Pubmed	Mouse 7S nerve growth factor: complete sequence of a cDNA coding for the alpha-subunit precursor and its relationship to serine proteases.	KLK3 KLK2	1.57e-05	3	80	2	6395888
Pubmed	Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.	SIGLEC8 KLK3 KLK2	2.29e-05	24	80	3	15331780
Pubmed	The presence of two types of prorenin converting enzymes in the mouse submandibular gland.	KLK3 KLK2	3.13e-05	4	80	2	1959648
Pubmed	Decreased flow-dependent dilation in carotid arteries of tissue kallikrein-knockout mice.	KLK3 KLK2	3.13e-05	4	80	2	11282893
GeneFamily	Kallikreins	KLK3 KLK2	6.49e-04	16	43	2	616
ToppCell	normal_Lung-Myeloid_cells-CD207+CD1a+_LCs\|normal_Lung / Location, Cell class and cell subclass	TCAF2 FAM234B ABI3 DSP TMEM8B MMP9	9.16e-07	181	80	6	b55dbcfae8c92d322071906831489830a22239b9
ToppCell	facs-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR NOTUM MRC2 COL27A1 PAM CREB3L1	1.41e-06	195	80	6	18b01ab63ee1deae3cf29669d66fff9ca4efc5c4
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CUBN MMP9 ADGRE1 KLK3 TMEFF2	1.04e-05	160	80	5	bb1bb3673059768c0ea0160d29fff127f3a4ecb4
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CUBN MMP9 ADGRE1 KLK3 TMEFF2	1.04e-05	160	80	5	76f49b8b4450fa8acd36326bfa36a5d1f4bd95fb
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|356C / Donor, Lineage, Cell class and subclass (all cells)	MRC1 FAM234B ZNF776 ITLN1 ALPK3	1.10e-05	162	80	5	2f19539c455d1e5d514725845234c7547020e6ad
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIP TSPOAP1 METRNL DSTYK TNKS1BP1	1.17e-05	164	80	5	b77995958c938e10a526118f75d78cee72e0b207
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABI3 SPOPL METRNL DSTYK ADGRE1	1.31e-05	168	80	5	e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABI3 METRNL NAB1 SIK1 ADGRE1	1.35e-05	169	80	5	411556e93adcbb7e4d79b02f3dc72963ec8a0759
ToppCell	droplet-Lung-LUNG-30m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABI3 METRNL NAB1 SIK1 ADGRE1	1.35e-05	169	80	5	39b1acfd099abb9de18c29c05c7a67709ea76775
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRSS1 NOTUM PRSS16 DSP ITLN1	1.60e-05	175	80	5	bffa623511ceb0b9bf76d87f9a10cfadfe0e940f
ToppCell	15-Trachea-Epithelial-Goblet-like_secretory\|Trachea / Age, Tissue, Lineage and Cell class	PRSS16 ITLN1 PAM MUC5AC CREB3L1	1.73e-05	178	80	5	f0557920b9b3e7c4f39938d1b524aa58711af4d2
ToppCell	COPD-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	TCAF2 NAB1 PAM TOX2 F5	1.83e-05	180	80	5	51a12fbad5fa7bb12e6d616a02ff9b5141e2b063
ToppCell	Mesenchymal_cells-Osteoblasts\|Mesenchymal_cells / Lineage and Cell class	NOTUM METRNL CTHRC1 CREB3L1 TG	1.98e-05	183	80	5	d6b52d52fe9a7a6c798947f05420d79fe12e4662
ToppCell	COPD-Lymphoid-T_Regulatory\|COPD / Disease state, Lineage and Cell class	TCAF2 NAB1 PAM TOX2 F5	2.09e-05	185	80	5	846403edd4c8f646201d519055198fc38b7ffff9
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-23\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHODL ALPK3 SIK1 ODC1 CHRNB1	2.20e-05	187	80	5	69b47f00598d647e2a99427ebddf42c339428e47
ToppCell	Mesenchymal_cells-Ng2+_MSCs\|Mesenchymal_cells / Lineage and Cell class	FANCC LIFR METRNL MMP9 CREB3L1	2.20e-05	187	80	5	e899b906409f3fad69cb3d3c6432c3fd862ae3c1
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-myofibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	LIFR PTPRG NOTUM SGCG CREB3L1	2.25e-05	188	80	5	116ca07ee4413dcc0e9e5ac99bfee6ed7b7847c6
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	LIFR PTPRG MRC2 KLK3 NACAD	2.25e-05	188	80	5	de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	LIFR PTPRG SGCG MRC2 CTHRC1	2.43e-05	191	80	5	cc9a6a8fad17d6e1a08a68ab7512ae06b1249051
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	LIFR PTPRG SGCG MRC2 CTHRC1	2.43e-05	191	80	5	c16b920ee69ea8536e020ac3475abf1ce972c1e6
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DSP ITLN1 FAM83E KLK3 CREB3L1	2.55e-05	193	80	5	402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC2 COL27A1 CTHRC1 CREB3L1 TMEFF2	2.55e-05	193	80	5	316ebdf15f75d88c348f909b643fcd315364ca84
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC2 COL27A1 CTHRC1 CREB3L1 TMEFF2	2.55e-05	193	80	5	1afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LIFR PTPRG SGCG MRC2 KLK3	2.55e-05	193	80	5	5e46a9f65e85aca78f825fdef88a95b97eec8743
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DSP ITLN1 FAM83E KLK3 CREB3L1	2.55e-05	193	80	5	7ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCell	droplet-Fat-Scat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC2 COL27A1 CTHRC1 CREB3L1 TMEFF2	2.55e-05	193	80	5	8dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCell	(1)_Osterolineage_cells\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	LIFR METRNL MRC2 CTHRC1 CREB3L1	2.55e-05	193	80	5	035eeea9f77c4bf9cd85f07fa791b6c857be76b5
ToppCell	COVID_vent-Myeloid-Monocytic-CD16+_Monocyte\|COVID_vent / Disease condition, Lineage, Cell class and subclass	MRC1 LILRA3 ABI3 ITLN1 ADGRE1	2.62e-05	194	80	5	b133d3d198360269cc449a75d34c29be377d91e0
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MRC1 ABI3 SIGLEC8 MMP9 ADGRE1	2.62e-05	194	80	5	44a90be1d2b2ae08f8c523bee65dd1e536ec0f95
ToppCell	10x5'v1-week_14-16-Mesenchymal_myocytic-stroma-myofibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	LIFR SGCG CYP26C1 CTHRC1 CREB3L1	2.68e-05	195	80	5	30ed961151b8b1f6ce37f06c9a061519f01c2864
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRSS16 EXPH5 ITLN1 FAM83E KLK3	2.68e-05	195	80	5	7ff04c45a02df01e3816f3c1d43585a93182a730
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRSS16 EXPH5 ITLN1 FAM83E KLK3	2.68e-05	195	80	5	09605533aa5947bb2e5a6725c1ce89f79d330bf5
ToppCell	severe_COVID-19-Non-classical_Monocyte\|severe_COVID-19 / disease group, cell group and cell class (v2)	MRC1 ABI3 METRNL ITLN1 ADGRE1	2.75e-05	196	80	5	34c1c74cad5e23196e86cfd6f19c836fe57b2264
ToppCell	(1)_T_cell-(15)_Treg\|(1)_T_cell / shred on Cell_type and subtype	MRC1 NAB1 PAM TOX2 F5	2.82e-05	197	80	5	6e7723e8b977be35c60cc11ac7cfa4f71339441e
ToppCell	NS-critical-d_16-33-Epithelial-Secretory\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAM83E PAM TNKS1BP1 MUC5AC CREB3L1	2.82e-05	197	80	5	a72047b7428c0d4aaf016c1ac23dc30919260fd8
ToppCell	Control_saline-Epithelial_alveolar-AT_1\|Control_saline / Treatment groups by lineage, cell group, cell type	DSP METRNL EXPH5 ITLN1 SIK1	2.89e-05	198	80	5	9b161285df7a4e51618f3517cfc5b8221ba55786
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Granulocytic_cells-Mast-cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DSTYK HRH4 ODC1 CUBN F5	2.96e-05	199	80	5	892ca0dc9928d3985bf99de8afc68c06d22e6e2e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM234B GRM3 MYRF NACAD TMEFF2	3.03e-05	200	80	5	56f1f007ba8c9188a4b10e52744f1e50dc0f155a
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DSP EXPH5 ITLN1 FAM83E MYRF	3.03e-05	200	80	5	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	AKAP9 MYCBP2 PAM TOX2 TMEFF2	3.03e-05	200	80	5	c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	FAM234B ZNF776 ITLN1 TNKS1BP1	7.63e-05	125	80	4	43aa4b77dccf0ea2979218826af16034f2017c3a
ToppCell	COVID-19_Mild-Neu_0\|World / 5 Neutrophil clusters in COVID-19 patients	TSPOAP1 COL27A1 ALPK3 PPP4R1L	1.18e-04	140	80	4	93f024473b1bb3bf93ae776fd6a8fc5e93d013f0
ToppCell	Mild/Remission-B_naive-13\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NOTUM DSP EXPH5 MRC2	1.25e-04	142	80	4	49873a2d9b1ae4bdbf253d1c09bf8845cc0cc917
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Nefm_(Layer_6a)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PRSS1 ADGRF3 TG	1.33e-04	55	80	3	b0d37faccc8d04433ee0e76cbce2410530c4c8a1
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Nefm_(Layer_6a)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PRSS1 ADGRF3 TG	1.33e-04	55	80	3	c3ebea1420b68638ed465a8cd8efba860650b795
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MRC1 ABI3 COL27A1 ADGRE1	1.50e-04	149	80	4	406a5ccfedbf43543f0346ff7ef3ce1d15c38f29
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MRC1 ABI3 COL27A1 ADGRE1	1.50e-04	149	80	4	34a3075af794052763fc7c4135f3031f89da5caa
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MRC1 ABI3 COL27A1 ADGRE1	1.50e-04	149	80	4	be698ecce34ddbdf57d08082b71268934675e74e
ToppCell	3'_v3-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3\|bone_marrow / Manually curated celltypes from each tissue	NOTUM MRC2 CTHRC1 TOX2	1.50e-04	149	80	4	d7f1069f70f3cad6d3700ee2041ed1d4cb7c49ab
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MRC1 ABI3 COL27A1 ADGRE1	1.50e-04	149	80	4	183c77cc8f23b8406e7241a066cb684470002a3b
ToppCell	facs-Marrow-Granulocytes-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GNB5 ALPK3 PAM CHRNB1	1.75e-04	155	80	4	cd2f3ad4f131588325a667b6724e530d821fbe30
ToppCell	facs-Marrow-Granulocytes-3m-Hematologic-MPP_Fraction_B\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GNB5 ALPK3 PAM CHRNB1	1.75e-04	155	80	4	9b26ade19488511c72b64335011d2dcd81e8f167
ToppCell	facs-Marrow-Granulocytes-3m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GNB5 ALPK3 PAM CHRNB1	1.75e-04	155	80	4	4246709e27703b94529369abbed5763e4002e79d
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ABI3 SIK1 ADGRE1	1.79e-04	156	80	4	d72c2f5f72d269e29033f8728d924e0d4c8772c7
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-5\|TCGA-Colorectal / Sample_Type by Project: Shred V9	PRSS16 KLK3 MUC5AC CREB3L1	1.84e-04	157	80	4	5fb41af247465aa29aa7b8edd26e3d3794766f80
ToppCell	facs-Marrow-B-cells-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 TCAF2 METRNL ADGRE1	1.84e-04	157	80	4	0966e347f8d32b13f8a3b3afba3f64637c69cdf9
ToppCell	facs-Marrow-B-cells-24m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 TCAF2 METRNL ADGRE1	1.84e-04	157	80	4	6ebfedd91d62c6d4aa8f046657a899a279f82ba2
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 METRNL ADGRE1 F5	1.88e-04	158	80	4	bdfa3aa1ffc025d846f14ccb3ca84d889916021f
ToppCell	Basal_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	DSP TMEM8B SIK1 NACAD	1.97e-04	160	80	4	b223cc47e68a29df4758c5ccf8f6dbffe2a6fa1d
ToppCell	VE-mono3\|VE / Condition, Cell_class and T cell subcluster	SGCG SIGLEC8 ALPK3 SIK1	2.02e-04	161	80	4	7df3fefc55ab43b897fc78d1f0c7383b10ac33d5
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 TSPOAP1 METRNL ADGRE1	2.02e-04	161	80	4	8937f6b92cb2a93ea8c4780d9200a518c3112e53
ToppCell	VE-mono3-\|VE / Condition, Cell_class and T cell subcluster	SGCG SIGLEC8 ALPK3 SIK1	2.02e-04	161	80	4	4e45bf7eceb0ee30dec4d8852778366776ea5a8f
ToppCell	droplet-Limb_Muscle-nan-18m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 COL27A1 CTHRC1 ADGRE1	2.07e-04	162	80	4	71d7849108a1b59beff40e46000172c45a2f5439
ToppCell	droplet-Fat-Gat-18m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 TSPOAP1 MMP9 ADGRE1	2.07e-04	162	80	4	052f797d8bcab8fc6a43e0bffdd215c88ee12889
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 METRNL ADGRE1 F5	2.07e-04	162	80	4	16d625ac6702f79a83af444d2b3bf6759fd17cf6
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MRC1 SLC35G6 MMP9 IPO11	2.12e-04	163	80	4	c21114826bee1b05b411984326fef6b6e0d05316
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITLN1 MUC5AC CREB3L1 TG	2.12e-04	163	80	4	22fa5d017ff796394394d952ec151e2d1beb8248
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MRC1 SLC35G6 MMP9 IPO11	2.12e-04	163	80	4	5d49414432db259a19df50d7944581d00b69f537
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ABI3 METRNL ADGRE1	2.17e-04	164	80	4	758e85e2f5e7236b345e16c78344d5e0bf17d8dc
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	FAM234B ZNF776 ITLN1 TNKS1BP1	2.17e-04	164	80	4	d6806deabf5f5c355934387be2baae125ac33fb8
ToppCell	367C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	AZIN2 TMEM8B CUBN TOX2	2.17e-04	164	80	4	95b800c78871354c859abaa832d778786ef7bcc0
ToppCell	facs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 CUBN ADGRE1 NACAD	2.22e-04	165	80	4	4f95c2fe5ab4416c736fe0d1936695a2b26777eb
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ABI3 METRNL ADGRE1	2.22e-04	165	80	4	11227bff52eed30b80937fdb1968d0b8e6d30365
ToppCell	facs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 CUBN ADGRE1 NACAD	2.22e-04	165	80	4	3e913b49a868fdd5589200ae3e9be77c0938ba14
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ABI3 METRNL ADGRE1	2.22e-04	165	80	4	036f9749048e5e50769cc3210339bf4da469215d
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ABI3 METRNL ADGRE1	2.27e-04	166	80	4	91eeb48680dd07ae4115afacdc0a8f6fa18885e5
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ABI3 METRNL ADGRE1	2.27e-04	166	80	4	b3d9b61847c6c96b8cb28b8a6aeda52f43c706ab
ToppCell	facs-Heart-LA-24m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 METRNL MMP9 ADGRE1	2.27e-04	166	80	4	2c931d593e189127c31adaf36a3df81d8287bb53
ToppCell	facs-Heart-LA-24m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 METRNL MMP9 ADGRE1	2.27e-04	166	80	4	9e7a9cb7beeb7015fcaa476a4902883dee99e8c0
ToppCell	facs-Heart-LA-24m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 METRNL MMP9 ADGRE1	2.27e-04	166	80	4	2a3c396deb068066b8c2f85ddd2fa52629776bcd
ToppCell	normal_Lung-Fibroblasts-Mesothelial_cells\|Fibroblasts / Location, Cell class and cell subclass	DSP ITLN1 FAM83E MUC5AC	2.32e-04	167	80	4	892a2dc83ab5de5a1016402f8e95d2aabf651326
ToppCell	droplet-Lung-30m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABI3 METRNL NAB1 SIK1	2.38e-04	168	80	4	d823979335ac6b5d1f062ebb741c759d2f919dbf
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue-6\|TCGA-Colorectal / Sample_Type by Project: Shred V9	LIFR CHODL SGCG TMEFF2	2.38e-04	168	80	4	5ce3129a023a48a3d7e6b9306c1fc5addfef9675
ToppCell	TCGA-Pancreas\|World / Sample_Type by Project: Shred V9	PRSS1 PNLIP MYRF MUC5AC	2.38e-04	168	80	4	279d5fcf9bd3f56ab560e37eed6fb3bd57dd93de
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like\|GI_small-bowel / Manually curated celltypes from each tissue	CYP26C1 MMP9 TOX2 CFHR4	2.38e-04	168	80	4	d02eba7ece17edcdd47fd6b784c93910ce61090f
ToppCell	droplet-Heart-nan-24m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 METRNL MMP9 ADGRE1	2.38e-04	168	80	4	0ef2d8dbcccc812dd0d99769048b95cf06faf023
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8\|TCGA-Thryoid / Sample_Type by Project: Shred V9	PTPRG NAB1 SLC2A13 ODC1	2.38e-04	168	80	4	00646601548b0fee42ae16bfa5e93603bc7c5129
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABI3 METRNL NAB1 ADGRE1	2.38e-04	168	80	4	4b5be7c6662eceddf90a65015f12908278d1664e
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABI3 METRNL NAB1 ADGRE1	2.38e-04	168	80	4	689c41f6e9f65381570991cc311cba49a57ec955
ToppCell	droplet-Lung-30m-Hematologic-myeloid-non-classical_monocyte\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABI3 METRNL NAB1 SIK1	2.38e-04	168	80	4	f377ff4c066a9857ad14d245e56325ad220e22e1
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CHODL SGCG FAM135B TMEFF2	2.43e-04	169	80	4	41cb92b0558f0d5a3e511058efd9110258b88ee3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FAM234B HRH4 TOX2 KLK2	2.43e-04	169	80	4	c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CHODL SGCG FAM135B TMEFF2	2.43e-04	169	80	4	91f4b6a14708e701b2af22989004282041777491
ToppCell	facs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK7 ADGRE1 F5 TG	2.43e-04	169	80	4	813472d429c0b12580b17b440e00a6d8beb7947f
ToppCell	droplet-Fat-Scat\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 METRNL CTHRC1 ADGRE1	2.49e-04	170	80	4	de722bea7527d6ad11b69f8e9589638f52854beb
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITLN1 FAM83E KLK3 CREB3L1	2.54e-04	171	80	4	48125d825ca2d7ef34564250f5b47d2a579e03c9
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 FAM234B SIK1 ADGRE1	2.54e-04	171	80	4	bf475a69db04d4a886e442704955c6a96ff0de46
ToppCell	droplet-Lung-1m-Hematologic-myeloid-non-classical_monocyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABI3 METRNL NAB1 SIK1	2.54e-04	171	80	4	00739085fdbc4d64c9faacba2c2adeab580dd2b1
ToppCell	droplet-Lung-1m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABI3 METRNL NAB1 SIK1	2.60e-04	172	80	4	5f58ff6cac32546d07b2a49ed250b6c7aa417188
ToppCell	droplet-Fat-Scat-18m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 METRNL CTHRC1 ADGRE1	2.60e-04	172	80	4	8a4a5ad65eec92ce4fa45c5aa01c28666307455b
Drug	rhamnose	MRC1 LIFR PRSS1 TSR1 MRC2 MMP9 KLK3 TOX2 MUC5AC TG	4.26e-07	356	79	10	CID000000840
Drug	Pro-phe-arg-mca	PRSS1 F5 KLK2 TG	9.36e-07	22	79	4	CID000174085
Drug	CHCl	PRSS1 SGCG PCSK7 KLK3 KLK2	3.10e-06	65	79	5	CID006432229
Drug	Flufenamic acid [530-78-9]; Up 200; 14.2uM; PC3; HT_HG-U133A	LIFR SIGLEC8 ETV2 FAM83E CUBN MMP9 CREB3L1	5.78e-06	198	79	7	5059_UP
Drug	AC1O3HX4	PNLIP ODC1	1.19e-05	2	79	2	CID006329008
Drug	LMWH	PRSS1 PNLIP NOTUM COL27A1 ODC1 MMP9 F5 KLK2 CREB3L1 CHRNB1 CFHR4	1.76e-05	663	79	11	CID000000772
Drug	Sialic acids	MRC1 PRSS1 SPOPL SIGLEC8 COL27A1 GNB5 MUC5AC TG	1.87e-05	329	79	8	CID000349960
Drug	18-hydroxy-11-deoxycortisol	ITLN1 TG	3.56e-05	3	79	2	CID003082415
Drug	premix	BCLAF1 PAM KLK3	3.74e-05	19	79	3	CID000013836
Drug	0ZI	PRSS1 PCSK7 F5	4.39e-05	20	79	3	CID000122235
Drug	Leupeptin hydrochloride	PRSS1 MRC2 CUBN MMP9 KLK3 KLK2 TG	4.91e-05	276	79	7	CID000003910
Drug	Amphotericin B [1397-89-3]; Up 200; 4.4uM; MCF7; HT_HG-U133A	MRC2 GRM3 F5 MUC5AC BAHD1 CHRNB1	6.40e-05	197	79	6	3303_UP
Drug	Mephenesin [59-47-2]; Down 200; 22uM; PC3; HT_HG-U133A	FAM234B TMEM8B PCSK7 MYRF CHRNB1 PRRC2B	6.40e-05	197	79	6	7374_DN
Drug	Iocetamic acid [16034-77-8]; Up 200; 6.6uM; MCF7; HT_HG-U133A	TSPOAP1 TMEM8B SIGLEC8 F5 MUC5AC CHRNB1	6.58e-05	198	79	6	4425_UP
Drug	Benzylpenicillin sodium [69-57-8]; Up 200; 11.2uM; PC3; HT_HG-U133A	FAM234B TSPOAP1 DSTYK HRH4 CHRNB1 MIR9-1HG	6.76e-05	199	79	6	4501_UP
Drug	Tetrahydroxy-1,4-quinone monohydrate [319-89-1]; Up 200; 21uM; MCF7; HT_HG-U133A	HRH4 ADGRE1 GRM3 F5 KLK2 MIR9-1HG	6.76e-05	199	79	6	3338_UP
Drug	epichlorohydrin triethanolamine	F5 TG	7.10e-05	4	79	2	CID000163191
Drug	merbarone	KLK3 KLK2	7.10e-05	4	79	2	ctd:C045459
Drug	N,N'-bis(3-aminopropyl)cadaverine	AZIN2 ODC1	7.10e-05	4	79	2	CID003080781
Disease	diabetes mellitus, family history	MYCBP2 PAM	6.72e-06	2	77	2	EFO_0000400, EFO_0000493
Disease	Insulinogenic index measurement	MYCBP2 PAM	6.69e-05	5	77	2	EFO_0009961
Disease	lysophosphatidylcholine 20:4 measurement	MYCBP2 SGCG MYRF	8.02e-05	32	77	3	EFO_0010363
Disease	tissue factor pathway inhibitor measurement	COL27A1 F5	1.40e-04	7	77	2	EFO_0007968
Disease	peptidyl-glycine alpha-amidating monooxygenase measurement	MYCBP2 PAM	3.64e-04	11	77	2	EFO_0801871
Disease	trimethylamine-N-oxide measurement	TTC13 CUBN	5.99e-04	14	77	2	EFO_0010541
Disease	early cardiac repolarization measurement	MYCBP2 PAM	5.99e-04	14	77	2	EFO_0004885
Disease	colorectal cancer, colorectal adenoma	METRNL TOX2 MYRF NACAD	6.84e-04	152	77	4	EFO_0005406, MONDO_0005575
Disease	cancer biomarker measurement	KLK2 FAM135B	6.90e-04	15	77	2	EFO_0005127
Disease	thrombosis (is_implicated_in)	MMP9 F5	6.90e-04	15	77	2	DOID:0060903 (is_implicated_in)
Disease	diabetes mellitus	MYCBP2 PAM TMEFF2	7.58e-04	68	77	3	EFO_0000400
Disease	hypertrophic cardiomyopathy (is_marker_for)	DSP MMP9	8.91e-04	17	77	2	DOID:11984 (is_marker_for)
Disease	total iron binding capacity	PRSS16 F5 MYRF	1.13e-03	78	77	3	EFO_0006334
Disease	response to angiotensin-converting enzyme inhibitor	GNB5 FAM135B TG	1.13e-03	78	77	3	EFO_0005325
Disease	glaucoma (is_marker_for)	MMP9 MUC5AC	1.24e-03	20	77	2	DOID:1686 (is_marker_for)
Disease	gastric ulcer (biomarker_via_orthology)	MMP9 MUC5AC	1.37e-03	21	77	2	DOID:10808 (biomarker_via_orthology)
Disease	Sjogren's syndrome (is_marker_for)	MMP9 MUC5AC	1.79e-03	24	77	2	DOID:12894 (is_marker_for)
Disease	Endogenous Hyperinsulinism	FANCC MRC1	2.10e-03	26	77	2	C1257963
Disease	Exogenous Hyperinsulinism	FANCC MRC1	2.10e-03	26	77	2	C1257964
Disease	Compensatory Hyperinsulinemia	FANCC MRC1	2.10e-03	26	77	2	C1257965
Disease	Colorectal Carcinoma	LIFR PRSS1 AKAP9 GNB5 ODC1 CUBN F5	2.38e-03	702	77	7	C0009402
Disease	Hyperinsulinism	FANCC MRC1	2.43e-03	28	77	2	C0020459
Disease	fat body mass	MYCBP2 PAM TTC13 FAM135B	2.53e-03	217	77	4	EFO_0005409
Disease	cerebral infarction (is_implicated_in)	F5 MYRF	2.61e-03	29	77	2	DOID:3526 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
YGPEHWVTSSVSCGG	PTPRG	66	P23470
CSSDSGSDWGQGIYL	AKAP9	2901	Q99996
STNLAYTAAWSPGEG	ADGRF3	361	Q8IZF5
YLSEAWPKDGGNGTS	CREB3L1	481	Q96BA8
GTCSDYPKGDASTGW	CTHRC1	216	Q96CG8
LYSSSLWGPAVDGCD	AZIN2	351	Q96A70
SGQWPTADLTGCYDL	GRM3	551	Q14832
EWGCAEAPTASGSSE	ALPK3	1736	Q96L96
CSSPGSGWGRGTDEY	CHRNB1	376	P11230
MPSSTGSYWFCDEGT	PAM	111	P19021
WESSFSPGAGGFCTT	MIR9-1HG	21	Q13536
TDKGEVYSCGWGADG	RCC1L	246	Q96I51
ITSSCYPGDGEAWGT	TSPOAP1	1516	O95153
SPDGTAFCSGSWDHT	GNB5	376	O14775
YSDGWCEGVSSEGTG	ABI3	341	Q9P2A4
YSACTTDGRSDGLPW	MMP9	241	P14780
SPQQCGDFSGFDWSG	ITLN1	276	Q8WWA0
PALGTTCYASGWGSI	KLK2	146	P20151
TCYASGWGSIEPEEF	KLK2	151	P20151
YERLGCFSDDSPWSG	PNLIP	21	P16233
EGSPTWLGISCSSYE	NAB1	101	Q13506
FVYGQGWSSCSPGRT	ATXN1L	546	P0C7T5
TGGDSWKYSLRPCTE	IPO11	396	Q9UI26
NDIYSCSWGPDDDGK	PCSK7	281	Q16549
DGDSGSIVWSYRAPC	FAM234B	461	A2RU67
SYHGSCPQGLADSAW	MRC2	1256	Q9UBG0
PSCDGNESWAYRSGT	EXPH5	1856	Q8NEV8
GGAGAQYSSDRCSWK	METRNL	41	Q641Q3
CSGWGDPHYITFDGT	MUC5AC	4921	P98088
GYLSSSHWNCGAPGQ	DSTYK	311	Q6XUX3
PYCSSDVWSGASSKS	NOTUM	181	Q6P988
RSGFSAYWDGSSTGC	CUBN	1151	O60494
AYWDGSSTGCGGNLT	CUBN	1156	O60494
SATSGDIWPGLSAYD	BCLAF1	206	Q9NYF8
GYTCQSGSGWDEFTK	DSP	171	P15924
DQTHGSCGGPFESWF	FANCC	381	Q00597
PPWGSSRYCSSEDTG	BAHD1	431	Q8TBE0
SWCAAGGPVSVYDAS	CYP26C1	171	Q6V0L0
VDGTYWVDPNLGCSS	COL27A1	1701	Q8IZC6
GEDGWSHFPTCYNSS	CFHR4	441	Q92496
DECWTGQTSDAGTYP	FAM135B	516	Q49AJ0
NTSWDCSVGPDGDTY	ETV2	151	O00321
TAGPYECEIWNSGSA	PSG11	211	Q9UQ72
SSYPGSDSWACPGNT	PPP4R1L	391	Q9P1A2
APRESYGADGTLCWS	PRAMEF26	321	H0Y7S4
STPWVAMGSAYGSCT	C3orf56	31	Q8N813
YSSSIWGPTCDGLDR	ODC1	351	P11926
SWKAPSGTGRGTDYE	LIFR	66	P42702
TCSGAYNLSSEWSAP	LILRA3	296	Q8N6C8
GLTYGSPSEGFTWSD	MRC1	716	P22897
YPLWARSTGNACSSG	SLC2A13	536	Q96QE2
SWKDEGSECEPGFFS	HRH4	156	Q9H3N8
QGLGTWTCSSSLYPS	TCAF2	511	A6NFQ2
SDCQTPTGWNCSGYD	TMEFF2	46	Q9UIK5
TDVDAGSLSYWPGQS	FAM83E	91	Q2M2I3
SGPESPGSACRAWAY	F5	1716	P12259
PCSFSYPQDGWTDSD	SIGLEC8	46	Q9NYZ4
GNFYKSGEPLSTWCG	SIK1B	171	A0A0B4J2F2
GNFYKSGEPLSTWCG	SIK1	171	P57059
YVAWARVSGPSSDCG	MYCBP2	1331	O75592
TWGPSGSSQSLYEIC	SGCG	251	Q13326
PSPYTGGAWATTGCS	ADGRD2	606	Q7Z7M1
GGAWATTGCSVAALY	ADGRD2	611	Q7Z7M1
CSCLDGFSSPTGNDW	ADGRE1	106	Q14246
PSYSSFTQGDSWGEG	ARL6IP6	26	Q8N6S5
TSGACPDLYQWSDGS	CHODL	111	Q9H9P2
PQSGDWGDQYSAECG	TTC13	76	Q8NBP0
DPLEGWDSTGDYCLS	TSR1	161	Q2NL82
AYFTLGAECPGWDST	TSPYL2	86	Q9H2G4
GAECPGWDSTIESGY	TSPYL2	91	Q9H2G4
CSPEAYSGGHDNSSW	RBMXL3	486	Q8N7X1
GDMSTGPIAESWCYT	SPOPL	11	Q6IQ16
SSWCQGASQDYGLGG	TNKS1BP1	746	Q9C0C2
SQYTSGSIGCDIPGW	UBR1	1481	Q8IWV7
SPGSSWQEYGPSDTC	PRRC2B	1231	Q5JSZ5
RGWGCTDSADALTYG	TMEM8B	216	A6NDV4
SQGLSGYDWCGLLGS	SLC35G6	151	P0C7Q6
DWDSSYPSGECGIST	TOX2	461	Q96NM4
ISGWGNTASSGADYP	PRSS1	141	P07477
PTYWSECGKNTESVG	TUT7	1221	Q5VYS8
GTSPRTWFGCSEGFY	TG	1431	P01266
SSPWICFGGSYAGSL	PRSS16	176	Q9NQE7
SSLGCWYGAKDETPS	ZNF776	51	Q68DI1
PALGTTCYASGWGSI	KLK3	146	P07288
TCYASGWGSIEPEEF	KLK3	151	P07288
PSGSYITADGDSWAS	NACAD	216	O15069
GGSEALCPWSSQSFG	MYRF	821	Q9Y2G1