Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	chromatin	NCOR1 FOXD4L4 FOXD4L6 TADA2A ZZZ3 VSX1 VSX2 FOXD4L3 FOXC1 FOXD4L5	2.32e-04	1480	38	10	GO:0000785
GeneOntologyCellularComponent	ATAC complex	TADA2A ZZZ3	2.89e-04	14	38	2	GO:0140672
GeneOntologyCellularComponent	mitotic spindle	ASPM NCOR1 TADA2A ZZZ3	4.74e-04	201	38	4	GO:0072686
Domain	TF_fork_head_CS_2	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	2.98e-08	46	37	5	IPR030456
Domain	TF_fork_head_CS_1	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	3.33e-08	47	37	5	IPR018122
Domain	FORK_HEAD_3	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	4.12e-08	49	37	5	PS50039
Domain	FH	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	4.12e-08	49	37	5	SM00339
Domain	FORK_HEAD_1	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	4.12e-08	49	37	5	PS00657
Domain	FORK_HEAD_2	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	4.12e-08	49	37	5	PS00658
Domain	Forkhead	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	4.12e-08	49	37	5	PF00250
Domain	Fork_head_dom	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	4.12e-08	49	37	5	IPR001766
Domain	CVC	VSX1 VSX2	3.82e-06	2	37	2	IPR023339
Domain	CVC	VSX1 VSX2	3.82e-06	2	37	2	PS51496
Domain	Myb_DNA-binding	NCOR1 TADA2A ZZZ3	4.48e-05	35	37	3	PF00249
Domain	-	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	6.65e-05	218	37	5	1.10.10.10
Domain	WHTH_DNA-bd_dom	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	1.09e-04	242	37	5	IPR011991
Domain	SANT	NCOR1 TADA2A ZZZ3	1.32e-04	50	37	3	SM00717
Domain	SANT/Myb	NCOR1 TADA2A ZZZ3	1.48e-04	52	37	3	IPR001005
Domain	-	NCOR1 TADA2A ZZZ3 VSX1 VSX2	2.26e-04	283	37	5	1.10.10.60
Domain	Homeodomain-like	NCOR1 TADA2A ZZZ3 VSX1 VSX2	4.71e-04	332	37	5	IPR009057
Domain	Znf_ZZ	TADA2A ZZZ3	6.39e-04	19	37	2	IPR000433
Domain	ZnF_ZZ	TADA2A ZZZ3	6.39e-04	19	37	2	SM00291
Domain	SANT_dom	NCOR1 TADA2A	1.20e-03	26	37	2	IPR017884
Domain	SANT	NCOR1 TADA2A	1.40e-03	28	37	2	PS51293
Domain	MYB_LIKE	NCOR1 TADA2A	2.57e-03	38	37	2	PS50090
Domain	Pkinase_C	PRKCH MAST3	3.13e-03	42	37	2	PF00433
Domain	Quinoprotein_ADH-like_supfam	ARHGAP27 PHIP	4.94e-03	53	37	2	IPR011047
Domain	AGC-kinase_C	PRKCH MAST3	5.50e-03	56	37	2	IPR000961
Domain	AGC_KINASE_CTER	PRKCH MAST3	5.50e-03	56	37	2	PS51285
Domain	S_TK_X	PRKCH MAST3	5.50e-03	56	37	2	SM00133
Domain	SAM_1	SASH1 SCML1	8.01e-03	68	37	2	PF00536
Domain	IQ	ASPM MYO15A	8.71e-03	71	37	2	PF00612
Domain	SH3	ARHGAP27 SASH1 MYO15A	8.87e-03	216	37	3	PS50002
Domain	SH3	ARHGAP27 SASH1 MYO15A	8.87e-03	216	37	3	SM00326
Domain	SH3_domain	ARHGAP27 SASH1 MYO15A	9.33e-03	220	37	3	IPR001452
Domain	IQ	ASPM MYO15A	1.12e-02	81	37	2	SM00015
Pubmed	Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	1.51e-12	13	38	5	7957066
Pubmed	Six members of the mouse forkhead gene family are developmentally regulated.	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	3.53e-12	15	38	5	7689224
Pubmed	Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.	FOXD4L4 FOXD4L6 FOXD4L3 FOXC1 FOXD4L5	5.13e-12	16	38	5	10208738
Pubmed	FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.	FOXD4L4 FOXD4L6 FOXC1 FOXD4L5	6.05e-12	5	38	4	12234674
Pubmed	Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.81e-11	6	38	4	27092474
Pubmed	The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	8.45e-11	8	38	4	8530406
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.52e-10	9	38	4	12412011
Pubmed	A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	8.60e-10	13	38	4	16884697
Pubmed	Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.64e-09	15	38	4	22045912
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	2.18e-09	16	38	4	8861101
Pubmed	Functional equivalency between Otx2 and Otx1 in development of the rostral head.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	4.64e-09	19	38	4	9895322
Pubmed	Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	5.79e-09	20	38	4	12812790
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	7.15e-09	21	38	4	9449667
Pubmed	Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	8.73e-09	22	38	4	17389379
Pubmed	Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.27e-08	24	38	4	11820816
Pubmed	A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.27e-08	24	38	4	29992973
Pubmed	Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.78e-08	26	38	4	15857913
Pubmed	Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	2.82e-08	29	38	4	22972626
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	FOXD4L4 FOXD4L6 VSX2 TERT FOXD4L3 FOXD4L5	3.98e-07	263	38	6	20932939
Pubmed	Genome-scale study of transcription factor expression in the branching mouse lung.	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	8.84e-07	67	38	4	22711520
Pubmed	Transcriptional activity of the paired-like homeodomain proteins CHX10 and VSX1.	VSX1 VSX2	1.16e-06	2	38	2	15647262
Pubmed	Nuclear export is evolutionarily conserved in CVC paired-like homeobox proteins and influences protein stability, transcriptional activation, and extracellular secretion.	VSX1 VSX2	3.48e-06	3	38	2	15767664
Pubmed	DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.	LIG4 TERT	6.96e-06	4	38	2	17145779
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	FOXD4L4 FOXD4L6 ZZZ3 VSX2 FOXD4L3 PHIP FOXD4L5	1.03e-05	709	38	7	22988430
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	FOXD4L4 FOXD4L6 FOXD4L3 PHIP FOXD4L5	2.02e-05	306	38	5	18973680
Pubmed	Vsx1, a rapidly evolving paired-like homeobox gene expressed in cone bipolar cells.	VSX1 VSX2	2.43e-05	7	38	2	11731243
Pubmed	Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina.	VSX1 VSX2	2.43e-05	7	38	2	17919464
Pubmed	Exocrine glands and the Chievitz organ of some mouse mutants.	VSX2 FOXC1	4.16e-05	9	38	2	5088022
Pubmed	Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.	FOXD4L4 FOXD4L3	6.35e-05	11	38	2	12421752
Pubmed	Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes.	VSX1 VSX2	6.35e-05	11	38	2	27477290
Pubmed	Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development.	VSX1 VSX2	6.35e-05	11	38	2	31822965
Pubmed	The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes.	TADA2A ZZZ3	6.35e-05	11	38	2	19936620
Pubmed	SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers.	TADA2A ZZZ3	6.35e-05	11	38	2	22055187
Pubmed	The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates.	TADA2A ZZZ3	9.00e-05	13	38	2	20562830
Pubmed	A conserved regulatory logic controls temporal identity in mouse neural progenitors.	VSX1 VSX2	1.21e-04	15	38	2	25654255
Pubmed	Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6.	VSX1 VSX2	1.21e-04	15	38	2	23172916
Pubmed	A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.	PRKCH CD2	1.38e-04	16	38	2	1832084
Pubmed	Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence.	VSX1 VSX2	1.38e-04	16	38	2	24125957
Pubmed	Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation.	VSX1 VSX2	1.76e-04	18	38	2	25989023
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ASPM TADA2A ZZZ3 PCMTD1 PHIP SCML1 FOXC1	1.82e-04	1116	38	7	31753913
Pubmed	The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development.	VSX1 VSX2	1.96e-04	19	38	2	16182275
Pubmed	Diverse fates of paralogs following segmental duplication of telomeric genes.	FOXD4L4 FOXD4L3	2.65e-04	22	38	2	15233989
Pubmed	MATH5 controls the acquisition of multiple retinal cell fates.	VSX1 VSX2	2.65e-04	22	38	2	21087508
Pubmed	Dicer is required for the transition from early to late progenitor state in the developing mouse retina.	VSX1 VSX2	2.90e-04	23	38	2	20237275
Pubmed	The double-histone-acetyltransferase complex ATAC is essential for mammalian development.	TADA2A ZZZ3	2.90e-04	23	38	2	19103755
Pubmed	Elavl2 Regulates Retinal Function Via Modulating the Differentiation of Amacrine Cells Subtype.	GJA10 VSX2	3.16e-04	24	38	2	34061953
Pubmed	Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina.	VSX1 VSX2	3.16e-04	24	38	2	17092954
Pubmed	Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina.	SLITRK6 VSX1	3.43e-04	25	38	2	28199486
Pubmed	Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord.	VSX1 VSX2	3.72e-04	26	38	2	28082864
Pubmed	Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.	TADA2A ZZZ3	4.01e-04	27	38	2	18838386
Pubmed	Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development.	VSX1 VSX2	4.01e-04	27	38	2	31968244
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXD4L4 ZZZ3 VSX1 VSX2 FOXD4L3 FOXC1	4.21e-04	908	38	6	19274049
Pubmed	Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis.	VSX1 VSX2	4.63e-04	29	38	2	30048641
Pubmed	Roles of histone H3K27 trimethylase Ezh2 in retinal proliferation and differentiation.	VSX1 VSX2	4.63e-04	29	38	2	25556712
Pubmed	Role of Elavl-like RNA-binding protein in retinal development and signal transduction.	GJA10 VSX2	5.30e-04	31	38	2	39307290
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	NCOR1 IFRD1 ZZZ3 PHIP FOXC1 NCBP3	5.47e-04	954	38	6	36373674
Pubmed	Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development.	VSX1 VSX2	6.01e-04	33	38	2	20463215
Pubmed	ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct.	TADA2A ZZZ3	1.07e-03	44	38	2	37682711
Cytoband	9q21.11	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.08e-08	30	38	4	9q21.11
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	FOXD4L4 FOXD4L3 FOXD4L5	6.05e-04	199	38	3	chr9q21
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	NCOR1 TADA2A ZZZ3	4.04e-05	53	23	3	532
GeneFamily	ATAC complex	TADA2A ZZZ3	1.20e-04	13	23	2	1058
GeneFamily	Sterile alpha motif domain containing	SASH1 SCML1	5.54e-03	88	23	2	760
GeneFamily	PRD class homeoboxes and pseudogenes	VSX1 VSX2	6.04e-03	92	23	2	521
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3	FOXD4L4 FOXD4L6 FOXD4L3 KCNJ4 FOXD4L5	1.30e-05	217	37	5	MM861
Coexpression	MORI_MATURE_B_LYMPHOCYTE_UP	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.51e-05	106	37	4	MM595
Coexpression	GSE13887_ACT_CD4_VS_NO_TREATED_CD4_TCELL_UP	XCR1 MYO15A VSX2 PUS7L	3.26e-05	129	37	4	M481
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	FOXD4L4 FOXD4L6 VSX2 FOXD4L3 FOXD4L5	4.57e-05	282	37	5	MM822
Coexpression	ESC_V6.5_UP_EARLY.V1_UP	ARHGAP27 SASH1 TERT MAST3	8.71e-05	166	37	4	M2770
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-Lymphoid_DC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXD4L4 FOXD4L6 VSX2 FOXD4L3	1.25e-05	168	38	4	6dd58fd981750da49afd53796f244e1803cce97f
ToppCell	wk_15-18-Hematologic-Myeloid-aDC_1\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5	1.54e-05	177	38	4	ccf5dc54780d6039a4d062dee88440c011ddc0a3
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	XCR1 FOXD4L4 FOXD4L3 FOXD4L5	1.64e-05	180	38	4	32d871738a24071b70084a7e80148a516110c78b
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	XCR1 FOXD4L4 FOXD4L3 FOXD4L5	1.64e-05	180	38	4	067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NCOR1 PRKCH CD2 NCBP3	2.25e-05	195	38	4	83c125223e7ca0f08a31414b3a16347912564765
Disease	clonal hematopoiesis	TERT INSL4	5.10e-05	10	32	2	EFO_0010819
Disease	lower urinary tract symptom, benign prostatic hyperplasia	TERT PHIP	5.54e-04	32	32	2	EFO_0000284, EFO_0008008
Disease	nasopharyngeal neoplasm	LIG4 TERT FOXC1	5.84e-04	151	32	3	EFO_0004252
Disease	reading and spelling ability	PRKCH SASH1 PHIP	7.69e-04	166	32	3	EFO_0005301
Disease	mean arterial pressure	TERT SLCO6A1 PHIP FOXC1	2.00e-03	499	32	4	EFO_0006340

Protein segments in the cluster

Peptide	Gene	Start	Entry
KRITKRLRKHRKFYT	C2orf16	1291	Q68DN1
VFYITKRKKQRSRRN	CD2	231	P06729
RAFEKDRQRKKSHLR	GJA10	101	Q969M2
IQAIFRGKKARRHLK	ASPM	2246	Q8IZT6
SRQHKELLRFRRKRK	GLRA3	341	O75311
HVPRRKRRNRFVKKN	KCNJ4	11	P48050
FFIKRRFRSLRHKII	MYO15A	1916	Q9UKN7
SFLRRRKRFKRHQLT	FOXD4L4	196	Q8WXT5
SFLRRRKRFKRHQLT	FOXD4L3	196	Q6VB84
RKRKRVKQRINTYVF	PCMTD1	276	Q96MG8
IEKKEQRAKRFHFRS	NCBP3	86	Q53F19
AAHQLKRRRRRKKQV	MIGA2	61	Q7L4E1
KIILSRKKRSGRHRF	INSL4	106	Q14641
ILRKGAKLFFRRRHQ	C2CD2	626	Q9Y426
RVADFKAFRRTFKRK	LIG4	871	P49917
SFLRRRRRFKKKDAV	FOXC1	166	Q12948
HRAKVDKRKQRSVFR	IFRD1	326	O00458
HRDTRQRFAIKKINK	MAST3	386	O60307
HLKKEKRRLNKRFSR	CCDC179	41	H3BU77
VIRRKVSKIQRFHAR	SCML1	81	Q9UN30
LVLHRRRRYKKKQVD	SLITRK6	631	Q9H5Y7
YHSRLKERQRRKKII	TADA2A	211	O75478
VTVRFREKAHKRGKR	PUS7L	276	Q9H0K6
SFLRRRKRFKRHQLT	FOXD4L5	196	Q5VV16
SFLRRRKRFKRHQLT	FOXD4L6	196	Q3SYB3
RKKLILFFKRRNHAR	NCOR1	286	O75376
KVRHKLRKFLQRRPT	ARHGAP27	666	Q6ZUM4
KARKRKQLHFFDSRL	SLCO6A1	346	Q86UG4
HKYRKLVKKTRFLRR	AURKAIP1	141	Q9NWT8
KRKKRRHRTVFTAHQ	VSX1	161	Q9NZR4
RSKRRHRTVKLIFAI	XCR1	216	P46094
FHKRNTITKRRKKRN	PHIP	1431	Q8WWQ0
VKFKRLHKLVNSTRR	SASH1	256	O94885
KAFSFKSNLKRHRRI	ZNF813	306	Q6ZN06
RKVFQVRRDLLKHKR	ZNF425	196	Q6IV72
FKNRKRHTRRVKLVF	ZZZ3	581	Q8IYH5
RHNERRFLRNTKKFI	TERT	481	O14746
NQTKKRKKRRHRTIF	VSX2	141	P58304
QRDRIFKHFTRKRQR	PRKCH	146	P24723