Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	SSTR4 PROKR2 OPN3 CASR C3AR1 DRD1 PTAFR HTR2B SSTR1	1.14e-07	884	21	9	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	SSTR4 PROKR2 ABCA7 OPN3 CASR C3AR1 DRD1 PTAFR HTR2B SSTR1	3.49e-07	1353	21	10	GO:0004888
GeneOntologyMolecularFunction	somatostatin receptor activity	SSTR4 SSTR1	1.05e-05	5	21	2	GO:0004994
GeneOntologyMolecularFunction	G-protein alpha-subunit binding	DRD1 PKD1L2 HTR2B	1.20e-05	43	21	3	GO:0001965
GeneOntologyMolecularFunction	neuropeptide receptor activity	SSTR4 PROKR2 SSTR1	2.27e-05	53	21	3	GO:0008188
GeneOntologyMolecularFunction	ATPase binding	WFS1 DRD1 ATP6V0A1	1.91e-04	108	21	3	GO:0051117
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	SSTR4 PROKR2 SSTR1	3.52e-04	133	21	3	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	SSTR4 PROKR2 SSTR1	4.09e-04	140	21	3	GO:0001653
GeneOntologyMolecularFunction	neuropeptide binding	SSTR4 SSTR1	6.86e-04	37	21	2	GO:0042923
GeneOntologyMolecularFunction	ATP-dependent activity	ABCA7 NLRP3 NLRP10 ATP6V0A1	3.49e-03	614	21	4	GO:0140657
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC30A1 PIEZO2 ATP6V0A1 PKD1L2	4.62e-03	664	21	4	GO:0008324
GeneOntologyMolecularFunction	neurotransmitter receptor activity	DRD1 HTR2B	4.90e-03	100	21	2	GO:0030594
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCA7 ATP6V0A1	5.79e-03	109	21	2	GO:0042626
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC30A1 ABCA7 PIEZO2 ATP6V0A1 PKD1L2	6.57e-03	1180	21	5	GO:0022857
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC30A1 PIEZO2 ATP6V0A1 PKD1L2	8.61e-03	793	21	4	GO:0015075
GeneOntologyMolecularFunction	transporter activity	SLC30A1 ABCA7 PIEZO2 ATP6V0A1 PKD1L2	9.49e-03	1289	21	5	GO:0005215
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCA7 NLRP3 NLRP10	1.06e-02	441	21	3	GO:0016887
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC30A1 ABCA7 ATP6V0A1	1.31e-02	477	21	3	GO:0022804
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCA7 ATP6V0A1	1.48e-02	178	21	2	GO:0015399
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled receptor signaling pathway	CASR C3AR1 DRD1 PTAFR HTR2B	1.94e-07	133	21	5	GO:0007200
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	SSTR4 DRD1 HTR2B SSTR1	3.99e-07	61	21	4	GO:0007187
GeneOntologyBiologicalProcess	response to abiotic stimulus	ABCA7 OPN3 CASR DRD1 NLRP3 PIEZO2 PTAFR PKD1L2 HTR2B	3.29e-06	1361	21	9	GO:0009628
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	SSTR4 PROKR2 OPN3 CASR C3AR1 DRD1 PTAFR HTR2B SSTR1	4.03e-06	1395	21	9	GO:0007186
GeneOntologyBiologicalProcess	calcium ion transport	SLC30A1 WFS1 CASR DRD1 PKD1L2 HTR2B	8.68e-06	509	21	6	GO:0006816
GeneOntologyBiologicalProcess	monoatomic cation transport	SLC30A1 WFS1 CASR DRD1 PIEZO2 ATP6V0A1 PKD1L2 HTR2B	1.01e-05	1157	21	8	GO:0006812
GeneOntologyBiologicalProcess	somatostatin receptor signaling pathway	SSTR4 SSTR1	1.48e-05	6	21	2	GO:0038169
GeneOntologyBiologicalProcess	somatostatin signaling pathway	SSTR4 SSTR1	1.48e-05	6	21	2	GO:0038170
GeneOntologyBiologicalProcess	cellular response to organic cyclic compound	SSTR4 CASR DRD1 PTAFR HTR2B SSTR1	2.31e-05	605	21	6	GO:0071407
GeneOntologyBiologicalProcess	intracellular monoatomic cation homeostasis	SLC30A1 WFS1 CASR DRD1 ATP6V0A1 HTR2B	2.45e-05	611	21	6	GO:0030003
GeneOntologyBiologicalProcess	intracellular calcium ion homeostasis	SLC30A1 WFS1 CASR DRD1 HTR2B	2.51e-05	359	21	5	GO:0006874
GeneOntologyBiologicalProcess	intracellular monoatomic ion homeostasis	SLC30A1 WFS1 CASR DRD1 ATP6V0A1 HTR2B	2.71e-05	622	21	6	GO:0006873
GeneOntologyBiologicalProcess	regulation of ERK1 and ERK2 cascade	SSTR4 ABCA7 CASR BTN2A1 HTR2B	3.51e-05	385	21	5	GO:0070372
GeneOntologyBiologicalProcess	monoatomic ion transport	SLC30A1 WFS1 CASR DRD1 PIEZO2 ATP6V0A1 PKD1L2 HTR2B	3.53e-05	1374	21	8	GO:0006811
GeneOntologyBiologicalProcess	calcium ion homeostasis	SLC30A1 WFS1 CASR DRD1 HTR2B	3.69e-05	389	21	5	GO:0055074
GeneOntologyBiologicalProcess	ERK1 and ERK2 cascade	SSTR4 ABCA7 CASR BTN2A1 HTR2B	5.19e-05	418	21	5	GO:0070371
GeneOntologyBiologicalProcess	monoatomic cation homeostasis	SLC30A1 WFS1 CASR DRD1 ATP6V0A1 HTR2B	5.46e-05	705	21	6	GO:0055080
GeneOntologyBiologicalProcess	monoatomic ion homeostasis	SLC30A1 WFS1 CASR DRD1 ATP6V0A1 HTR2B	5.99e-05	717	21	6	GO:0050801
GeneOntologyBiologicalProcess	positive regulation of transport	SSTR4 WFS1 ABCA7 OPN3 CASR DRD1 PTAFR	6.47e-05	1081	21	7	GO:0051050
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC30A1 CASR DRD1 PIEZO2 ATP6V0A1 PKD1L2 HTR2B	7.88e-05	1115	21	7	GO:0034220
GeneOntologyBiologicalProcess	positive regulation of ERK1 and ERK2 cascade	SSTR4 ABCA7 CASR HTR2B	9.16e-05	240	21	4	GO:0070374
GeneOntologyBiologicalProcess	gastro-intestinal system smooth muscle contraction	PTAFR HTR2B	1.03e-04	15	21	2	GO:0014831
GeneOntologyBiologicalProcess	regulation of MAPK cascade	SSTR4 ABCA7 CASR BTN2A1 DRD1 HTR2B	1.22e-04	815	21	6	GO:0043408
GeneOntologyBiologicalProcess	chemical homeostasis	SLC30A1 WFS1 CASR DRD1 ATP6V0A1 HTR2B SCD5	1.61e-04	1249	21	7	GO:0048878
GeneOntologyBiologicalProcess	negative regulation of endoplasmic reticulum unfolded protein response	WFS1 ABCA7	1.67e-04	19	21	2	GO:1900102
GeneOntologyBiologicalProcess	intracellular chemical homeostasis	SLC30A1 WFS1 CASR DRD1 ATP6V0A1 HTR2B	1.70e-04	866	21	6	GO:0055082
GeneOntologyBiologicalProcess	positive regulation of MAPK cascade	SSTR4 ABCA7 CASR DRD1 HTR2B	2.25e-04	571	21	5	GO:0043410
GeneOntologyBiologicalProcess	vasoconstriction	CASR DRD1 HTR2B	2.42e-04	121	21	3	GO:0042310
GeneOntologyBiologicalProcess	positive regulation of T-helper 17 type immune response	NLRP3 NLRP10	2.47e-04	23	21	2	GO:2000318
GeneOntologyBiologicalProcess	MAPK cascade	SSTR4 ABCA7 CASR BTN2A1 DRD1 HTR2B	2.50e-04	930	21	6	GO:0000165
GeneOntologyBiologicalProcess	positive regulation of cytokine production	C3AR1 NLRP3 NLRP10 PTAFR HTR2B	2.54e-04	586	21	5	GO:0001819
GeneOntologyBiologicalProcess	neuropeptide signaling pathway	SSTR4 PROKR2 SSTR1	2.61e-04	124	21	3	GO:0007218
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	SLC30A1 DRD1 PIEZO2 ATP6V0A1 PKD1L2 HTR2B	2.68e-04	942	21	6	GO:0098655
GeneOntologyBiologicalProcess	regulation of calcium ion transport	SLC30A1 WFS1 CASR DRD1	2.86e-04	323	21	4	GO:0051924
GeneOntologyBiologicalProcess	smooth muscle contraction	DRD1 PTAFR HTR2B	3.20e-04	133	21	3	GO:0006939
GeneOntologyBiologicalProcess	cellular homeostasis	SLC30A1 WFS1 CASR DRD1 ATP6V0A1 HTR2B	3.34e-04	981	21	6	GO:0019725
GeneOntologyBiologicalProcess	inorganic ion homeostasis	SLC30A1 WFS1 CASR DRD1 HTR2B	3.34e-04	622	21	5	GO:0098771
GeneOntologyBiologicalProcess	metal ion transport	SLC30A1 WFS1 CASR DRD1 PKD1L2 HTR2B	3.70e-04	1000	21	6	GO:0030001
GeneOntologyBiologicalProcess	regulation of cytokine production	C3AR1 BTN2A1 NLRP3 NLRP10 PTAFR HTR2B	3.91e-04	1010	21	6	GO:0001817
GeneOntologyBiologicalProcess	blood circulation	CASR C3AR1 DRD1 PTAFR HTR2B	4.04e-04	648	21	5	GO:0008015
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC30A1 CASR DRD1 ATP6V0A1 PKD1L2 HTR2B	4.05e-04	1017	21	6	GO:0098660
GeneOntologyBiologicalProcess	phasic smooth muscle contraction	DRD1 HTR2B	4.22e-04	30	21	2	GO:0014821
GeneOntologyBiologicalProcess	chemosensory behavior	WFS1 CASR	4.51e-04	31	21	2	GO:0007635
GeneOntologyBiologicalProcess	response to organic cyclic compound	SSTR4 CASR DRD1 PTAFR HTR2B SSTR1	4.76e-04	1048	21	6	GO:0014070
GeneOntologyBiologicalProcess	cellular response to abiotic stimulus	OPN3 NLRP3 PIEZO2 PTAFR	4.84e-04	371	21	4	GO:0071214
GeneOntologyBiologicalProcess	cellular response to environmental stimulus	OPN3 NLRP3 PIEZO2 PTAFR	4.84e-04	371	21	4	GO:0104004
GeneOntologyBiologicalProcess	positive regulation of calcium ion transport	WFS1 CASR DRD1	4.92e-04	154	21	3	GO:0051928
GeneOntologyBiologicalProcess	regulation of endoplasmic reticulum unfolded protein response	WFS1 ABCA7	5.43e-04	34	21	2	GO:1900101
GeneOntologyBiologicalProcess	cytokine production	C3AR1 BTN2A1 NLRP3 NLRP10 PTAFR HTR2B	5.90e-04	1091	21	6	GO:0001816
GeneOntologyBiologicalProcess	detection of stimulus	OPN3 CASR NLRP3 PIEZO2 PKD1L2	6.61e-04	722	21	5	GO:0051606
GeneOntologyBiologicalProcess	defense response to bacterium	SLC30A1 NLRP3 NLRP10 SCD5	6.73e-04	405	21	4	GO:0042742
GeneOntologyBiologicalProcess	detection of external stimulus	OPN3 PIEZO2 PKD1L2	6.90e-04	173	21	3	GO:0009581
GeneOntologyBiologicalProcess	response to lipid	SSTR4 CASR NLRP3 PTAFR SSTR1 SCD5	6.97e-04	1126	21	6	GO:0033993
GeneOntologyBiologicalProcess	circulatory system process	CASR C3AR1 DRD1 PTAFR HTR2B	7.08e-04	733	21	5	GO:0003013
GeneOntologyBiologicalProcess	detection of abiotic stimulus	OPN3 PIEZO2 PKD1L2	7.14e-04	175	21	3	GO:0009582
GeneOntologyBiologicalProcess	cellular response to lipid	SSTR4 CASR NLRP3 PTAFR SSTR1	7.76e-04	748	21	5	GO:0071396
GeneOntologyBiologicalProcess	regulation of T-helper 17 type immune response	NLRP3 NLRP10	1.04e-03	47	21	2	GO:2000316
GeneOntologyBiologicalProcess	blood vessel diameter maintenance	CASR DRD1 HTR2B	1.08e-03	202	21	3	GO:0097746
GeneOntologyBiologicalProcess	regulation of tube diameter	CASR DRD1 HTR2B	1.08e-03	202	21	3	GO:0035296
GeneOntologyBiologicalProcess	regulation of tube size	CASR DRD1 HTR2B	1.10e-03	203	21	3	GO:0035150
GeneOntologyBiologicalProcess	negative regulation of response to endoplasmic reticulum stress	WFS1 ABCA7	1.13e-03	49	21	2	GO:1903573
GeneOntologyBiologicalProcess	ER-nucleus signaling pathway	WFS1 ABCA7	1.32e-03	53	21	2	GO:0006984
GeneOntologyBiologicalProcess	response to nitrogen compound	WFS1 CASR DRD1 NLRP3 PTAFR HTR2B	1.32e-03	1272	21	6	GO:1901698
GeneOntologyBiologicalProcess	positive regulation of immune response	C3AR1 BTN2A1 NLRP3 NLRP10 PTAFR	1.34e-03	845	21	5	GO:0050778
GeneOntologyBiologicalProcess	regulation of metal ion transport	SLC30A1 WFS1 CASR DRD1	1.40e-03	493	21	4	GO:0010959
GeneOntologyBiologicalProcess	positive regulation of intracellular signal transduction	SSTR4 ABCA7 CASR DRD1 NLRP3 HTR2B	1.47e-03	1299	21	6	GO:1902533
GeneOntologyBiologicalProcess	regulation of response to external stimulus	CASR C3AR1 DRD1 NLRP3 NLRP10 NLRP8	1.58e-03	1316	21	6	GO:0032101
GeneOntologyBiologicalProcess	response to amine	DRD1 HTR2B	1.58e-03	58	21	2	GO:0014075
GeneOntologyBiologicalProcess	behavior	WFS1 ABCA7 CASR DRD1 HTR2B	1.70e-03	891	21	5	GO:0007610
GeneOntologyBiologicalProcess	sensory perception of mechanical stimulus	WFS1 PIEZO2 LHFPL3	1.73e-03	238	21	3	GO:0050954
GeneOntologyBiologicalProcess	regulation of calcium ion import	SLC30A1 CASR	1.74e-03	61	21	2	GO:0090279
GeneOntologyBiologicalProcess	T-helper 17 type immune response	NLRP3 NLRP10	1.92e-03	64	21	2	GO:0072538
GeneOntologyBiologicalProcess	cellular response to dopamine	DRD1 HTR2B	1.92e-03	64	21	2	GO:1903351
GeneOntologyBiologicalProcess	response to bacterium	SLC30A1 NLRP3 NLRP10 PTAFR SCD5	1.92e-03	916	21	5	GO:0009617
GeneOntologyBiologicalProcess	circadian rhythm	PROKR2 OPN3 DRD1	1.95e-03	248	21	3	GO:0007623
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	SLC30A1 DRD1 ATP6V0A1 PKD1L2 HTR2B	1.97e-03	922	21	5	GO:0098662
GeneOntologyBiologicalProcess	response to dopamine	DRD1 HTR2B	2.04e-03	66	21	2	GO:1903350
GeneOntologyBiologicalProcess	cellular response to monoamine stimulus	DRD1 HTR2B	2.16e-03	68	21	2	GO:0071868
GeneOntologyBiologicalProcess	cellular response to catecholamine stimulus	DRD1 HTR2B	2.16e-03	68	21	2	GO:0071870
GeneOntologyBiologicalProcess	response to fatty acid	PTAFR SCD5	2.22e-03	69	21	2	GO:0070542
GeneOntologyBiologicalProcess	calcium-mediated signaling	C3AR1 DRD1 HTR2B	2.38e-03	266	21	3	GO:0019722
GeneOntologyBiologicalProcess	positive regulation of monoatomic ion transport	WFS1 CASR DRD1	2.38e-03	266	21	3	GO:0043270
HumanPheno	Polydipsia	PROKR2 WFS1 CASR NLRP3	7.09e-07	53	8	4	HP:0001959
HumanPheno	Abnormal drinking behavior	PROKR2 WFS1 CASR NLRP3	3.96e-06	81	8	4	HP:0030082
HumanPheno	Progressive sensorineural hearing impairment	WFS1 NLRP3 SCD5	7.15e-05	57	8	3	HP:0000408
HumanPheno	Reduced impulse control	PROKR2 WFS1 ABCA7 CASR NLRP3 PIEZO2 ATP6V0A1	9.08e-05	1032	8	7	HP:5200045
HumanPheno	Progressive hearing impairment	WFS1 NLRP3 SCD5	1.01e-04	64	8	3	HP:0001730
MousePheno	increased acute inflammation	SSTR4 C3AR1 NLRP3 PTAFR	6.17e-05	164	19	4	MP:0005088
MousePheno	abnormal hypersensitivity reaction	SSTR4 C3AR1 NLRP3 PTAFR	7.77e-05	174	19	4	MP:0002148
MousePheno	abnormal acute inflammation	SSTR4 C3AR1 NLRP3 NLRP10 PTAFR	9.14e-05	357	19	5	MP:0002498
MousePheno	abnormal T-helper 2 physiology	C3AR1 BTN2A1 NLRP10	9.65e-05	67	19	3	MP:0005466
MousePheno	decreased susceptibility to experimental autoimmune encephalomyelitis	C3AR1 NLRP3 NLRP10	1.83e-04	83	19	3	MP:0004800
Domain	GPCR_Rhodpsn_7TM	SSTR4 PROKR2 OPN3 C3AR1 DRD1 PTAFR HTR2B SSTR1	3.54e-07	670	21	8	IPR017452
Domain	7tm_1	SSTR4 PROKR2 OPN3 C3AR1 DRD1 PTAFR HTR2B SSTR1	3.83e-07	677	21	8	PF00001
Domain	G_PROTEIN_RECEP_F1_1	SSTR4 PROKR2 OPN3 C3AR1 DRD1 PTAFR HTR2B SSTR1	4.19e-07	685	21	8	PS00237
Domain	G_PROTEIN_RECEP_F1_2	SSTR4 PROKR2 OPN3 C3AR1 DRD1 PTAFR HTR2B SSTR1	4.47e-07	691	21	8	PS50262
Domain	GPCR_Rhodpsn	SSTR4 PROKR2 OPN3 C3AR1 DRD1 PTAFR HTR2B SSTR1	4.52e-07	692	21	8	IPR000276
Domain	PYRIN	NLRP3 NLRP10 NLRP8	1.86e-06	22	21	3	SM01289
Domain	DAPIN	NLRP3 NLRP10 NLRP8	1.86e-06	22	21	3	PS50824
Domain	DAPIN	NLRP3 NLRP10 NLRP8	1.86e-06	22	21	3	IPR004020
Domain	PYRIN	NLRP3 NLRP10 NLRP8	1.86e-06	22	21	3	PF02758
Domain	NACHT	NLRP3 NLRP10 NLRP8	2.14e-06	23	21	3	PS50837
Domain	NACHT_NTPase	NLRP3 NLRP10 NLRP8	2.14e-06	23	21	3	IPR007111
Domain	7TM_GPCR_Srsx	SSTR4 DRD1 HTR2B SSTR1	6.78e-06	112	21	4	SM01381
Domain	Somatstn_rcpt	SSTR4 SSTR1	1.20e-05	5	21	2	IPR000586
Domain	-	NLRP3 NLRP10 NLRP8	1.49e-04	93	21	3	1.10.533.10
Domain	DEATH-like_dom	NLRP3 NLRP10 NLRP8	1.79e-04	99	21	3	IPR011029
Domain	LRR_6	NLRP3 NLRP8	1.72e-03	55	21	2	PF13516
Domain	P-loop_NTPase	ABCA7 NLRP3 NLRP10 NLRP8	1.36e-02	848	21	4	IPR027417
Pathway	WP_GPCRS_NONODORANT	SSTR4 PROKR2 OPN3 CASR C3AR1 DRD1 PTAFR HTR2B SSTR1	5.65e-12	266	17	9	MM15843
Pathway	REACTOME_GPCR_LIGAND_BINDING	SSTR4 PROKR2 OPN3 CASR C3AR1 DRD1 PTAFR HTR2B SSTR1	4.12e-10	430	17	9	MM15160
Pathway	REACTOME_GPCR_LIGAND_BINDING	SSTR4 PROKR2 OPN3 CASR C3AR1 DRD1 PTAFR HTR2B SSTR1	7.92e-10	463	17	9	M507
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	SSTR4 PROKR2 OPN3 C3AR1 DRD1 PTAFR HTR2B SSTR1	1.68e-09	330	17	8	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	SSTR4 PROKR2 OPN3 C3AR1 DRD1 PTAFR HTR2B SSTR1	1.80e-09	333	17	8	MM14963
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	SSTR4 OPN3 C3AR1 DRD1 PTAFR HTR2B SSTR1	1.11e-08	260	17	7	M39397
Pathway	REACTOME_SIGNALING_BY_GPCR	SSTR4 PROKR2 OPN3 CASR C3AR1 DRD1 PTAFR HTR2B SSTR1	1.47e-08	646	17	9	MM14962
Pathway	REACTOME_SIGNALING_BY_GPCR	SSTR4 PROKR2 OPN3 CASR C3AR1 DRD1 PTAFR HTR2B SSTR1	3.04e-08	702	17	9	M746
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	SSTR4 OPN3 C3AR1 PTAFR HTR2B SSTR1	5.34e-08	186	17	6	MM15994
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	SSTR4 C3AR1 DRD1 PTAFR HTR2B SSTR1	5.06e-07	272	17	6	M13380
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	SSTR4 OPN3 CASR C3AR1 SSTR1	1.77e-05	289	17	5	MM15057
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	SSTR4 OPN3 CASR C3AR1 SSTR1	2.64e-05	314	17	5	M600
Pathway	WP_GPCRS_PEPTIDE	SSTR4 C3AR1 SSTR1	7.59e-05	70	17	3	MM15959
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	SSTR4 PROKR2 C3AR1 SSTR1	7.63e-05	197	17	4	MM14970
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	SSTR4 PROKR2 C3AR1 SSTR1	7.63e-05	197	17	4	M12289
Pathway	WP_PEPTIDE_GPCRS	SSTR4 C3AR1 SSTR1	9.32e-05	75	17	3	M39696
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	PROKR2 CASR PTAFR HTR2B	9.78e-05	210	17	4	MM15043
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	PROKR2 CASR PTAFR HTR2B	1.11e-04	217	17	4	M18437
Pathway	REACTOME_PURINERGIC_SIGNALING_IN_LEISHMANIASIS_INFECTION	C3AR1 NLRP3	4.37e-04	26	17	2	M29838
Pathway	WP_MONOAMINE_GPCRS	DRD1 HTR2B	6.24e-04	31	17	2	MM15871
Pathway	WP_MONOAMINE_GPCRS	DRD1 HTR2B	7.07e-04	33	17	2	M39585
Pathway	WP_NUCLEOTIDEBINDING_OLIGOMERIZATION_DOMAIN_NOD_PATHWAY	NLRP3 NLRP10	1.09e-03	41	17	2	M39698
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	DRD1 HTR2B	1.15e-03	42	17	2	MM14971
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	DRD1 HTR2B	1.15e-03	42	17	2	M5868
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	DRD1 PTAFR HTR2B	1.18e-03	178	17	3	M2890
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY	PTAFR HTR2B	1.62e-03	50	17	2	M47951
Pathway	WP_CIRCADIAN_RHYTHM_GENES	PROKR2 OPN3 DRD1	1.68e-03	201	17	3	M39605
Pathway	KEGG_GAP_JUNCTION	DRD1 HTR2B	5.15e-03	90	17	2	M4013
Pathway	WP_GPCRS_OTHER	CASR DRD1	5.84e-03	96	17	2	MM15939
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	SSTR4 OPN3 CASR DRD1 HTR2B SSTR1	1.69e-09	200	21	6	18240029
Pubmed	NODs: intracellular proteins involved in inflammation and apoptosis.	NLRP3 NLRP10 NLRP8	4.16e-08	12	21	3	12766759
Pubmed	Dissociation of heterotrimeric g proteins in cells.	SSTR4 CASR C3AR1 PTAFR SSTR1	6.50e-08	179	21	5	18577758
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP3 NLRP10 NLRP8	6.88e-08	14	21	3	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP3 NLRP10 NLRP8	6.88e-08	14	21	3	12563287
Pubmed	Stable association between G alpha(q) and phospholipase C beta 1 in living cells.	PROKR2 CASR PTAFR HTR2B	3.02e-07	95	21	4	16754659
Pubmed	Calcium-sensing receptor activates the NLRP3 inflammasome in LS14 preadipocytes mediated by ERK1/2 signaling.	CASR NLRP3	3.47e-07	2	21	2	29345311
Pubmed	Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors.	CASR NLRP3	1.04e-06	3	21	2	23271661
Pubmed	Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of Alzheimer's disease.	C3AR1 NLRP3	1.04e-06	3	21	2	39218048
Pubmed	Molecular cloning and expression of a type-two somatostatin receptor in goldfish brain and pituitary.	SSTR4 SSTR1	2.08e-06	4	21	2	10996426
Pubmed	NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.	NLRP3 NLRP10	2.08e-06	4	21	2	22538615
Pubmed	Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain.	SSTR4 SSTR1	2.08e-06	4	21	2	8405411
Pubmed	Somatostatin sst2 receptor knock-out mice: localisation of sst1-5 receptor mRNA and binding in mouse brain by semi-quantitative RT-PCR, in situ hybridisation histochemistry and receptor autoradiography.	SSTR4 SSTR1	3.47e-06	5	21	2	11897118
Pubmed	Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.	C3AR1 NLRP3	3.47e-06	5	21	2	23817414
Pubmed	Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.	SSTR4 SSTR1	3.47e-06	5	21	2	12021920
Pubmed	Immunohistochemical detection and localization of somatostatin receptor subtypes in prostate tissue from patients with bladder outlet obstruction.	SSTR4 SSTR1	3.47e-06	5	21	2	18936524
Pubmed	The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.	CASR NLRP3	3.47e-06	5	21	2	23143333
Pubmed	[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy].	SSTR4 SSTR1	3.47e-06	5	21	2	11753241
Pubmed	Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.	SSTR4 SSTR1	3.47e-06	5	21	2	8449518
Pubmed	Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.	SSTR4 SSTR1	3.47e-06	5	21	2	9279525
Pubmed	An immunohistochemical investigation of the expression of somatostatin receptor subtypes - should therapeutic trials be performed to determine the efficacy of somatostatin analogs in treating advanced thyroid malignances?	SSTR4 SSTR1	3.47e-06	5	21	2	25962406
Pubmed	Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.	SSTR4 SSTR1	3.47e-06	5	21	2	11344221
Pubmed	Characterisation of [125I]-Tyr0DTrp8-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain.	SSTR4 SSTR1	3.47e-06	5	21	2	12759718
Pubmed	Acromegaly: correlation between expression of somatostatin receptor subtypes and response to octreotide-lar treatment.	SSTR4 SSTR1	3.47e-06	5	21	2	19330452
Pubmed	Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease.	SSTR4 SSTR1	3.47e-06	5	21	2	12414882
Pubmed	Interaction of brain somatostatin receptors with the PDZ domains of PSD-95.	SSTR4 SSTR1	3.47e-06	5	21	2	17950729
Pubmed	Prognostic Value of Somatostatin Receptor Subtypes in Pancreatic Neuroendocrine Tumors.	SSTR4 SSTR1	3.47e-06	5	21	2	26474434
Pubmed	Somatostatin receptor subtypes in human type 2 diabetic islets.	SSTR4 SSTR1	3.47e-06	5	21	2	20182388
Pubmed	Profiling of somatostatin receptor subtype expression by quantitative PCR and correlation with clinicopathological features in pancreatic endocrine tumors.	SSTR4 SSTR1	3.47e-06	5	21	2	20717067
Pubmed	Brain somatostatin receptors are up-regulated in somatostatin-deficient mice.	SSTR4 SSTR1	5.20e-06	6	21	2	12145348
Pubmed	Identification and characterization of a novel human cortistatin-like peptide.	SSTR4 SSTR1	5.20e-06	6	21	2	9125122
Pubmed	Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.	DRD1 NLRP3	5.20e-06	6	21	2	25594175
Pubmed	Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.	SSTR4 SSTR1	5.20e-06	6	21	2	9205124
Pubmed	Genetic variation in the SST gene and its receptors in relation to circulating levels of insulin-like growth factor-I, IGFBP3, and prostate cancer risk.	SSTR4 SSTR1	5.20e-06	6	21	2	19423539
Pubmed	Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.	SSTR4 SSTR1	5.20e-06	6	21	2	1346068
Pubmed	Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.	SSTR4 SSTR1	7.28e-06	7	21	2	25149275
Pubmed	Structural, expression, and evolutionary analysis of mouse CIAS1.	NLRP3 NLRP10	7.28e-06	7	21	2	15302403
Pubmed	Null mutant mouse models of somatostatin and cortistatin, and their receptors.	SSTR4 SSTR1	7.28e-06	7	21	2	18206294
Pubmed	Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain.	SSTR4 SSTR1	7.28e-06	7	21	2	22581439
Pubmed	PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.	NLRP3 NLRP10	7.28e-06	7	21	2	15817483
Pubmed	Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study.	SSTR4 SSTR1	1.56e-05	10	21	2	16214911
Pubmed	An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies.	C3AR1 HTR2B SSTR1	1.75e-05	84	21	3	15123239
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	SSTR4 PROKR2 DRD1 SSTR1	2.06e-05	275	21	4	20734064
Pubmed	NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.	NLRP3 NLRP10	2.28e-05	12	21	2	21565393
Pubmed	Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis.	C3AR1 NLRP3	2.28e-05	12	21	2	24743949
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	SSTR4 DRD1 HTR2B SSTR1	2.89e-05	300	21	4	19086053
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	WFS1 ABCA7 ATP6V0A1 PTAFR HTR2B	4.97e-05	697	21	5	28298427
Pubmed	Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.	SSTR4 SSTR1	5.28e-05	18	21	2	20810604
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	SLC30A1 ABCA7 CASR DRD1	6.81e-05	374	21	4	19625176
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	SLC30A1 ABCA7 CASR DRD1	7.32e-05	381	21	4	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	SLC30A1 ABCA7 CASR DRD1	7.40e-05	382	21	4	19170196
Pubmed	Transcription Factor VAX1 Regulates the Regional Specification of the Subpallium Through Repressing Gsx2.	PROKR2 DRD1	7.96e-05	22	21	2	33821423
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	SLC30A1 ABCA7 CASR DRD1	1.08e-04	421	21	4	19692168
Pubmed	Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs.	SSTR4 SSTR1	1.12e-04	26	21	2	9226367
Interaction	SST interactions	SSTR4 SSTR1	3.71e-05	9	21	2	int:SST
Interaction	SNTA1 interactions	C3AR1 HTR2B SSTR1	1.71e-04	105	21	3	int:SNTA1
Interaction	HTR3A interactions	ABCA7 BTN2A1 ATP6V0A1	1.86e-04	108	21	3	int:HTR3A
Interaction	CORT interactions	SSTR4 SSTR1	2.15e-04	21	21	2	int:CORT
Interaction	KIAA2013 interactions	NLRP3 ATP6V0A1 PTAFR	2.29e-04	116	21	3	int:KIAA2013
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP3 NLRP10 NLRP8	1.88e-06	25	18	3	994
GeneFamily	NLR family	NLRP3 NLRP10 NLRP8	1.88e-06	25	18	3	666
GeneFamily	Somatostatin receptors	SSTR4 SSTR1	9.35e-06	5	18	2	257
CoexpressionAtlas	Myeloid Cells, DC.103-11b+24-.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24-, Lung, avg-2	C3AR1 NLRP3 PTAFR	5.82e-05	81	20	3	GSM854271_100
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3\|Hippocampus / BrainAtlas - Mouse McCarroll V32	OPN3 DRD1 PKD1L2 SSTR1	4.87e-07	138	21	4	b63e26afafbd2cdeed9c9451e6f530ab6295504c
ToppCell	Frontal_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	C3AR1 NLRP3 PTAFR	3.76e-05	140	21	3	2c04fa782aa076e4be8a2781aa04231180bd69bd
ToppCell	Frontal_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia.C1qb.Tmem119-Fos)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	C3AR1 NLRP3 PTAFR	3.76e-05	140	21	3	a9389a6e55d02d5037868c9ecce48b5e8d7c2902
ToppCell	Frontal_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	C3AR1 NLRP3 PTAFR	3.76e-05	140	21	3	8db98a17a4d4b42dbfc75e9cdaa22275fed4f2f0
ToppCell	Frontal_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia.C1qb.Tmem119-Fos)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	C3AR1 NLRP3 PTAFR	3.76e-05	140	21	3	22098203361f61b9f0ce9f0f2d1369d8bb1379a8
ToppCell	10x5'-bone_marrow-Myeloid_Monocytic-Cycling_mono\|bone_marrow / Manually curated celltypes from each tissue	NLRP3 ATP6V0A1 PTAFR	4.44e-05	148	21	3	de35eeefad0e27a0d127e2e4bedead2bddb75152
ToppCell	frontal_cortex-Non-neuronal-macrophage-Macrophage-PVM_Mrc1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C3AR1 NLRP3 PTAFR	4.44e-05	148	21	3	d3ea907f8f408e9bb97ed223a3089e403e35f911
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	4.44e-05	148	21	3	7c7c87b57aa16f8b91698489df39ace5a3a53df8
ToppCell	Hippocampus-Hematopoietic\|Hippocampus / BrainAtlas - Mouse McCarroll V32	C3AR1 NLRP3 PTAFR	4.71e-05	151	21	3	81b2189afd72658f7e2539b856ba79cd49340215
ToppCell	droplet-Mammary_Gland-nan-3m-Myeloid\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	5.00e-05	154	21	3	12d3ecb0c4d814a91ac833fcb74db6b9dbc0a321
ToppCell	droplet-Mammary_Gland-nan-3m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	5.00e-05	154	21	3	64192a0f78021551886bbaf929916392bce451c0
ToppCell	droplet-Mammary_Gland-nan-3m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	5.00e-05	154	21	3	93ace0a42f3ea94605b13acd79659602b3a31b74
ToppCell	facs-MAT-Fat-24m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 PTAFR PKD1L2	5.10e-05	155	21	3	d0c1608f8f6b6f4174e51d610501c707cba5e015
ToppCell	Globus_pallidus-Hematopoietic\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	C3AR1 NLRP3 PTAFR	5.19e-05	156	21	3	67cdaadc3b917f7072adce16c0391472c14a2563
ToppCell	droplet-Kidney-nan-18m-Myeloid-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NLRP3 NLRP10 PTAFR	5.29e-05	157	21	3	eb64a4e89843895d16015c7d51805f164ed7ea5b
ToppCell	Frontal_cortex-Hematopoietic-MICROGLIA\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	C3AR1 NLRP3 PTAFR	5.50e-05	159	21	3	41d2c1e71f6983156f8cc8ec5f69e025e5700f46
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	WFS1 ABCA7 SCD5	5.60e-05	160	21	3	58ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCell	Frontal_cortex-Hematopoietic\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	C3AR1 NLRP3 PTAFR	5.60e-05	160	21	3	70ffbe61cfd729519b23569a43d929b117ab8d5e
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	5.71e-05	161	21	3	3db97af49520dc8cbafb4454d8afd9d588160e89
ToppCell	droplet-Fat-Mat-18m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASR C3AR1 NLRP3	5.71e-05	161	21	3	8c62ae3fcf304db0f71633e328ceba81a70f03c4
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	5.71e-05	161	21	3	f1d258c81bcf0f3c52bd20aa58faa9a5fd888168
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	5.71e-05	161	21	3	787f91f906756ef570c0d02936c3cdfafb3f7454
ToppCell	AT1_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	WFS1 ABCA7 SCD5	5.81e-05	162	21	3	ae2ba4f21f6f6c512006fa531d670b88be7c04c9
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	5.81e-05	162	21	3	db1e09324e9fdd5e571600cff4f2b1c0cb3c179d
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C3AR1 NLRP3 PTAFR	5.81e-05	162	21	3	ec29c6f1c31e41ddcb041a49c593910edaf0532c
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Myeloid-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	5.81e-05	162	21	3	9734943c8b7c04e568792253b7352672a3a5cc58
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	5.81e-05	162	21	3	48d7bee271f74b5d06c03c6ae06a662d765a6de3
ToppCell	AT1-AT2_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	LHFPL3 NLRP8 SCD5	5.81e-05	162	21	3	57d627259d27f39885bf416d74bcb6656db6e27b
ToppCell	facs-MAT-Fat-3m-Myeloid-myeloid_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	5.92e-05	163	21	3	5fc836444bc156c8248abee001b0ecbe43f980c9
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	C3AR1 NLRP3 PTAFR	5.92e-05	163	21	3	a6e272e043859858084b8d4d96fa4ff9e6eca454
ToppCell	E17.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	C3AR1 NLRP3 PTAFR	6.03e-05	164	21	3	4e9de41ea10ce3233c09e144bfc0453c0ae79fd3
ToppCell	E17.5-Endothelial-lymphatic_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	C3AR1 NLRP3 PTAFR	6.03e-05	164	21	3	6f4914b0ac282b4b9f6111930a82515178c1bc80
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Myeloid\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	6.14e-05	165	21	3	518ee34c18065100a2f2c6e407d3a7866b908593
ToppCell	droplet-Limb_Muscle-nan-21m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	6.14e-05	165	21	3	c2fc76feff58d77128f5a5318fed9c265574d760
ToppCell	droplet-Limb_Muscle-nan-21m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	6.14e-05	165	21	3	5f23173ec624ea7f893d22e326446f0e39e30b4e
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Myeloid-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	6.14e-05	165	21	3	becb8f726b84509ec29c75b530a3fe757651301d
ToppCell	droplet-Limb_Muscle-nan-21m-Myeloid-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	6.14e-05	165	21	3	1760ec2ac8913a2b33f46672a3f39ca7489966b8
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Myeloid-macrophage\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	6.14e-05	165	21	3	ae8dd9c00f96590f27ed21cd6314f4577e00e312
ToppCell	PCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_mast/basophil_(18)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	C3AR1 NLRP3 PTAFR	6.25e-05	166	21	3	f03f78cae6272c89618c0bda032ce45c4fc96baa
ToppCell	Thalamus-Hematopoietic\|Thalamus / BrainAtlas - Mouse McCarroll V32	C3AR1 NLRP3 PTAFR	6.25e-05	166	21	3	76d60ac7ac5d1eaf530f0c741d9c48e0bd58396b
ToppCell	facs-GAT-Fat-24m-Myeloid-myeloid_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	6.36e-05	167	21	3	5d9ffbcb539d9c50cef9dd792ea11aa37dd2c1df
ToppCell	facs-GAT-Fat-24m-Myeloid\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	6.36e-05	167	21	3	c31e41fb76ba261ac546fac3cc2b8337e39bfa86
ToppCell	facs-GAT-Fat-24m-Myeloid-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	6.36e-05	167	21	3	a04d1f2413fd24ad5e9cc67312220606157fecf3
ToppCell	facs-MAT-Fat-24m-Myeloid\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	6.47e-05	168	21	3	6514a27a54ea0f07172b3a73270250143a7b14f0
ToppCell	facs-MAT-Fat-24m-Myeloid-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	6.47e-05	168	21	3	0b6bb335e93476b13955543eeb487243b0067369
ToppCell	droplet-Bladder-BLADDER-1m-Hematologic-leukocyte\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PKD1L2	6.59e-05	169	21	3	b46e446067c6425bd5b8ef7719aeecff5e861249
ToppCell	droplet-Bladder-BLADDER-1m-Hematologic\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PKD1L2	6.59e-05	169	21	3	5508b03fbf483fce7701d6c82c297ffda3b1ba05
ToppCell	facs-Trachea-24m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C3AR1 NLRP3 PTAFR	6.59e-05	169	21	3	8180aeda13c511260d0542a94156059d558848a7
ToppCell	facs-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C3AR1 NLRP3 PTAFR	6.70e-05	170	21	3	f524b73d65941ebef7671c46df4362a3f15d24fc
ToppCell	facs-Trachea-nan-18m-Myeloid-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	6.70e-05	170	21	3	774b0c1b453e19651f9481dc6bcabac538c5acb7
ToppCell	facs-Trachea-18m-Hematologic-myeloid-tracheal_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C3AR1 NLRP3 PTAFR	6.70e-05	170	21	3	e4856e768d0088e42fbdb8e6039f5bc3daa0afdb
ToppCell	facs-Trachea-18m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C3AR1 NLRP3 PTAFR	6.82e-05	171	21	3	26755e43d94e934106fc19ab929e4d34c17d6cba
ToppCell	facs-Trachea-18m-Hematologic-myeloid\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C3AR1 NLRP3 PTAFR	6.94e-05	172	21	3	c260680f5455fce133b7b4158b4197fc76115779
ToppCell	facs-Trachea-nan-3m-Myeloid-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	7.06e-05	173	21	3	e4eb2ac2cee16bfa8eabc938f8030ee161c972c5
ToppCell	facs-Trachea-nan-3m-Myeloid\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	7.06e-05	173	21	3	371515471459307a3b2adce735263b4aac828956
ToppCell	facs-Trachea-nan-3m-Myeloid-macrophage\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	7.06e-05	173	21	3	4e9b6c71030ae0d63d54e7255e4a10b25970fcc4
ToppCell	facs-Trachea-24m-Hematologic-myeloid-tracheal_macrophage\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C3AR1 NLRP3 PTAFR	7.06e-05	173	21	3	7300b1ea8090cc5cd327a7207330eca538c27e63
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SLC30A1 OPN3 PIEZO2	7.18e-05	174	21	3	cb0109661e8c9ca04d67d33f2d926f0e649bf67d
ToppCell	facs-Trachea-24m-Hematologic-myeloid\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C3AR1 NLRP3 PTAFR	7.18e-05	174	21	3	2f25fba5225f4687df4396645e94565a640b5583
ToppCell	facs-Trachea-3m-Hematologic-myeloid-tracheal_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C3AR1 NLRP3 PTAFR	7.18e-05	174	21	3	d67fc8e30cc67fff8f7fdeaccb409d12ca0992c1
ToppCell	facs-Trachea-3m-Hematologic-myeloid\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C3AR1 NLRP3 PTAFR	7.31e-05	175	21	3	22fd7d9b4d403cc8061316855f78bad0eb705ce9
ToppCell	facs-Kidney-nan-18m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	7.31e-05	175	21	3	cec941edec6849f2fb602c08fd1eed6d0345f934
ToppCell	facs-Kidney-nan-18m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	7.31e-05	175	21	3	2cb0d07a47bc645cfa690bb853e11d657af19ede
ToppCell	AT1-AT2_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	WFS1 ABCA7 SCD5	7.31e-05	175	21	3	9a95ab5c361ebaa8747983c5a0d69025682a19ad
ToppCell	facs-Kidney-nan-18m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3AR1 NLRP3 PTAFR	7.31e-05	175	21	3	24d58e2f6d36124bde0f2c6f5357b9161bc5f476
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA7 C3AR1 PTAFR	7.43e-05	176	21	3	183ba1aa5cf594b88ec08e0e41241668b51256a9
ToppCell	facs-Trachea-3m-Hematologic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C3AR1 NLRP3 PTAFR	7.56e-05	177	21	3	c9d235fc518b291ed98088a1206d14d6692bc7fd
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	7.56e-05	177	21	3	cdad5a2f672a7f07c05669bfcaf1ec74defd3de7
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	7.56e-05	177	21	3	991ae76bb615392d84aeb89886148fa42c1c649c
ToppCell	Posterior_cortex-Hematopoietic\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	C3AR1 NLRP3 PTAFR	7.68e-05	178	21	3	ea9e4f461dda34c0ebc707d7dbefc7a49ce5bb55
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-cDC2\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C3AR1 NLRP3 PTAFR	7.68e-05	178	21	3	8184a2b9872f7ca12a9823535de485e841aeffb1
ToppCell	Control-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	7.81e-05	179	21	3	c4ff8b191ed0f6dc2dd784869f6f2c62e170a7db
ToppCell	Control-Myeloid-Monocytes,_Macrophages\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	7.81e-05	179	21	3	a79a244bf8ecc333d034b2eb2de554d3310ca6de
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-Macrophages\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C3AR1 NLRP3 PTAFR	7.94e-05	180	21	3	7af90f0e7ca001bf1fe5c860ee54c4cc8eb483bf
ToppCell	AT1_cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	WFS1 ABCA7 SCD5	7.94e-05	180	21	3	e1964002681f80d8d62406b6ee52a01e1829ccf2
ToppCell	LPS-IL1RA-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	7.94e-05	180	21	3	97241f62ee133dcb0d4855ffda5dd1349de9f7b2
ToppCell	LPS-IL1RA-Myeloid-Monocytes,_Macrophages\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	7.94e-05	180	21	3	41896546cd1cc458e08c0d4e19aa4860e5d4fcd6
ToppCell	AT1-AT2_cells-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	WFS1 ABCA7 SCD5	8.07e-05	181	21	3	ca23ce4f2c7b684d8ddd0e8619b3b696023d75e3
ToppCell	Control-Myeloid\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	8.07e-05	181	21	3	25170e5285996cc80337d5f86a0255569861ae77
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC30A1 PIEZO2 HTR2B	8.07e-05	181	21	3	cd81bc307e2bc42c1e9b24d5645ab65fa18c6133
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	8.21e-05	182	21	3	d5d6bc16458bc665e7ad6669040d79f73f640044
ToppCell	LPS_only-Myeloid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	8.21e-05	182	21	3	666ac86ee5f6fa9241ae8d80340743707e54b278
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	8.21e-05	182	21	3	0b59ead4bb4486c7ec2ee90b94ee3a09905612c5
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	C3AR1 NLRP3 PTAFR	8.34e-05	183	21	3	614a1c08cf6d01a4f1ed2fb816cd1a6e0c3207ce
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	WFS1 ABCA7 SCD5	8.48e-05	184	21	3	c7073d1b2c4fdb154d87678b92a0629c02116972
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	WFS1 ABCA7 SCD5	8.48e-05	184	21	3	bde4eaabd3e9bdaed23867d23a919b9d84b52d4b
ToppCell	5'-Adult-LymphNode-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C3AR1 NLRP3 PTAFR	8.48e-05	184	21	3	ba260f8a2e6e510141a6b9c458eb0040acff0352
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)\|343B / Donor, Lineage, Cell class and subclass (all cells)	WFS1 ABCA7 SCD5	8.48e-05	184	21	3	cb15d6bae52c5ec251c2235859dc7e65f630ae23
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WFS1 ABCA7 SCD5	8.48e-05	184	21	3	ca940a4f4970285ed284d5517d142abab0682044
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	WFS1 ABCA7 SCD5	8.48e-05	184	21	3	1ed558a88215b248431c524ea16f13d9022ae98c
ToppCell	LPS-IL1RA-Myeloid\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	8.61e-05	185	21	3	9b5fd87ea9d05e051ff1251578ecfbe5e8652853
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte2_(4)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	C3AR1 NLRP3 PTAFR	8.75e-05	186	21	3	cb4ea1bc1427230070e9696baeda7de241c354b1
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	C3AR1 NLRP3 PTAFR	8.75e-05	186	21	3	05c40bac5c0ade8b67b7c2112739466e02dbf22b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LHFPL3 PTAFR SCD5	8.75e-05	186	21	3	b3358e0fa6d845c81e94d56c8575f016621d28ff
ToppCell	LPS-antiTNF-Myeloid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	8.75e-05	186	21	3	839c6da5244f469461b2e5563e36162b2911cd01
ToppCell	LPS-IL1RA+antiTNF-Myeloid\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C3AR1 NLRP3 PTAFR	8.89e-05	187	21	3	4e0bbef6ba0d1b3e1f8d900d4a9dbd41f09a7bc5
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_migrating_dendritic_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	C3AR1 NLRP3 PTAFR	9.03e-05	188	21	3	8fc15c8b78fdd1a578e34325011bc5a87a8aab31
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	C3AR1 NLRP3 PTAFR	9.18e-05	189	21	3	440c422369de1c49112d18cf8c506a2a3a81f6ba
ToppCell	Monocytes-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	CASR C3AR1 NLRP3	9.18e-05	189	21	3	2164adbe1b0e8e4d39644546b7dfb19e9ea4f7b9
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_macrophage\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	C3AR1 NLRP3 PTAFR	9.18e-05	189	21	3	a438c64a893d43f781ede42e1c7b615b74dc76ef
Drug	Zwittergent 3-12	SSTR4 ATP6V0A1 SSTR1	5.47e-07	18	21	3	CID000084703
Drug	AC1LA7UO	SSTR4 DRD1 SSTR1	3.30e-06	32	21	3	CID000483172
Drug	5-HIAA	SSTR4 DRD1 HTR2B SSTR1	5.46e-06	129	21	4	CID000001826
Drug	Triflupromazine	DRD1 HTR2B	8.09e-06	5	21	2	DB00508
Drug	SCH 24518	DRD1 HTR2B	8.09e-06	5	21	2	CID000146265
Drug	proterguride	DRD1 HTR2B	8.09e-06	5	21	2	CID000071999
Drug	Sch-38548	DRD1 HTR2B	1.21e-05	6	21	2	CID000130519
Drug	Bim23268	SSTR4 SSTR1	1.70e-05	7	21	2	CID005311026
Drug	flumezapine	DRD1 HTR2B	1.70e-05	7	21	2	CID000043602
Drug	Ee 581	SSTR4 SSTR1	2.26e-05	8	21	2	CID003036100
Drug	cabergoline	DRD1 HTR2B	2.26e-05	8	21	2	ctd:C047047
Drug	BIM 23034	SSTR4 SSTR1	2.26e-05	8	21	2	CID005492589
Drug	Somatostatin	SSTR4 SSTR1	2.26e-05	8	21	2	ctd:D013004
Drug	ritanserin	DRD1 NLRP10 HTR2B	2.35e-05	61	21	3	CID000005074
Drug	zenarestat	SSTR4 CASR SSTR1	2.85e-05	65	21	3	CID000005724
Drug	CHEBI:334542	DRD1 HTR2B	2.91e-05	9	21	2	CID010884046
Drug	X Bb	SSTR4 SSTR1	2.91e-05	9	21	2	CID000445281
Drug	CHEBI:334375	DRD1 HTR2B	2.91e-05	9	21	2	CID010476504
Drug	NIASP	DRD1 HTR2B	2.91e-05	9	21	2	CID006439184
Drug	Tyr(3)-sms	SSTR4 SSTR1	2.91e-05	9	21	2	CID000123864
Drug	Minaprine	DRD1 HTR2B	2.91e-05	9	21	2	DB00805
Drug	genistein; Down 200; 1uM; MCF7; HG-U133A	C3AR1 BTN2A1 PIEZO2 ATP6V0A1	3.02e-05	199	21	4	267_DN
Drug	W-13, hydrochloride; Up 200; 10uM; MCF7; HG-U133A	SSTR4 CASR ATP6V0A1 PTAFR	3.08e-05	200	21	4	643_UP
Drug	Vapreotide	SSTR4 DRD1 SSTR1	3.26e-05	68	21	3	CID000071306
Drug	Peptavlon	SSTR4 NLRP3 SSTR1	4.92e-05	78	21	3	CID000021701
Drug	S 14506	DRD1 HTR2B	5.32e-05	12	21	2	CID000131905
Drug	Chlorprothixene	DRD1 HTR2B	5.32e-05	12	21	2	DB01239
Drug	HCNO	ATP6V0A1 SCD5	5.32e-05	12	21	2	CID000521293
Drug	AC1L1JSL	DRD1 PTAFR HTR2B	5.51e-05	81	21	3	CID000005188
Drug	Cabergoline-d5	DRD1 HTR2B SSTR1	5.93e-05	83	21	3	CID000002512
Drug	Edotreotide	SSTR4 SSTR1	6.28e-05	13	21	2	CID000158782
Drug	Sordinol	DRD1 HTR2B	6.28e-05	13	21	2	CID000012453
Drug	Calcium	SLC30A1 CASR DRD1 PTAFR HTR2B	7.12e-05	493	21	5	ctd:D002118
Drug	Lisuride	DRD1 HTR2B	7.32e-05	14	21	2	DB00589
Drug	Pramipexole	DRD1 HTR2B	7.32e-05	14	21	2	DB00413
Drug	SRA 880	SSTR4 SSTR1	7.32e-05	14	21	2	CID005311376
Drug	Ropinirole	DRD1 HTR2B	7.32e-05	14	21	2	DB00268
Drug	A 86929	DRD1 PTAFR	8.45e-05	15	21	2	ctd:C095427
Drug	L-817,818	SSTR4 SSTR1	8.45e-05	15	21	2	CID005311375
Drug	Cabergoline	DRD1 HTR2B	8.45e-05	15	21	2	DB00248
Drug	Apomorphine	DRD1 HTR2B	8.45e-05	15	21	2	DB00714
Drug	L-796,778	SSTR4 SSTR1	9.65e-05	16	21	2	CID005311373
Drug	Pergolide	DRD1 HTR2B	9.65e-05	16	21	2	ctd:D010479
Drug	aporphine	DRD1 PTAFR	1.09e-04	17	21	2	CID000114911
Drug	Pergolide	DRD1 HTR2B	1.09e-04	17	21	2	DB01186
Drug	spirodecanone	DRD1 HTR2B	1.23e-04	18	21	2	CID000070556
Drug	L-803,087	SSTR4 SSTR1	1.23e-04	18	21	2	CID005311374
Drug	Cycam	SSTR4 SSTR1	1.23e-04	18	21	2	CID000122080
Drug	pasireotide	SSTR4 SSTR1	1.23e-04	18	21	2	ctd:C517782
Drug	Bromocriptine	DRD1 HTR2B	1.23e-04	18	21	2	DB01200
Drug	Nozinan	DRD1 HTR2B	1.23e-04	18	21	2	CID000003916
Drug	tiospirone	DRD1 HTR2B	1.37e-04	19	21	2	CID000055751
Drug	NSC186067	DRD1 HTR2B	1.37e-04	19	21	2	CID000004140
Drug	S-20499	DRD1 HTR2B	1.37e-04	19	21	2	CID000121851
Drug	quinagolide	DRD1 SSTR1	1.37e-04	19	21	2	CID000055645
Drug	butyrophenone	DRD1 HTR2B	1.37e-04	19	21	2	CID000010315
Drug	RP 62203	DRD1 HTR2B	1.37e-04	19	21	2	CID000060785
Drug	SB 200646A	DRD1 HTR2B	1.37e-04	19	21	2	CID000126769
Drug	SCH 39166	DRD1 HTR2B	1.52e-04	20	21	2	CID000107930
Drug	2,5-dimethoxy-4-iodoamphetamine	DRD1 NLRP10 HTR2B	1.64e-04	117	21	3	CID000001229
Drug	L-779,976	SSTR4 SSTR1	1.68e-04	21	21	2	CID005311372
Drug	Gadolinium	CASR DRD1	1.68e-04	21	21	2	ctd:D005682
Drug	Photofrin	DRD1 HTR2B	1.68e-04	21	21	2	CID000057166
Drug	NSC186061	DRD1 NLRP10 HTR2B	1.69e-04	118	21	3	CID000004163
Drug	BP 897	DRD1 HTR2B	1.85e-04	22	21	2	CID003038494
Drug	setoperone	DRD1 HTR2B	1.85e-04	22	21	2	CID000068604
Drug	Lanthanum	CASR DRD1	1.85e-04	22	21	2	ctd:D007811
Drug	perazine	DRD1 HTR2B	2.03e-04	23	21	2	CID000004744
Drug	ANB-NOS	SSTR4 SSTR1	2.03e-04	23	21	2	CID003080866
Drug	DL-tryptophan	OPN3 DRD1 HTR2B	2.05e-04	126	21	3	CID000001148
Drug	ketanserin	DRD1 NLRP10 HTR2B	2.29e-04	131	21	3	CID000003822
Drug	Inositol 1,4,5-Trisphosphate	CASR HTR2B	2.40e-04	25	21	2	ctd:D015544
Drug	butamifos	SSTR4 SSTR1	2.60e-04	26	21	2	CID000037419
Drug	tardan	DRD1 HTR2B	2.60e-04	26	21	2	CID000002729
Drug	Rc 121	SSTR4 SSTR1	2.60e-04	26	21	2	CID000127388
Drug	triflupromazine	DRD1 HTR2B	2.80e-04	27	21	2	CID000005568
Drug	NSC169490	DRD1 HTR2B	2.80e-04	27	21	2	CID004210613
Drug	ergolines	DRD1 HTR2B	2.80e-04	27	21	2	CID003083577
Drug	fluperlapine	DRD1 HTR2B	2.80e-04	27	21	2	CID000049381
Drug	eniluracil	SSTR4 SSTR1	2.80e-04	27	21	2	CID000043157
Drug	L-741,626	DRD1 HTR2B	3.02e-04	28	21	2	CID000133633
Drug	dtpa-sms	SSTR4 SSTR1	3.02e-04	28	21	2	CID000072128
Drug	roxindole	DRD1 HTR2B	3.02e-04	28	21	2	CID000219050
Drug	NSC407316	DRD1 HTR2B	3.02e-04	28	21	2	CID000003067
Drug	prochlorperazine	DRD1 HTR2B	3.24e-04	29	21	2	CID000004917
Drug	AC1L1G8Z	DRD1 HTR2B	3.47e-04	30	21	2	CID000003581
Drug	Tt 232	SSTR4 SSTR1	3.47e-04	30	21	2	CID000164469
Drug	mesulergine	DRD1 HTR2B	3.71e-04	31	21	2	CID000068848
Drug	AN-201	SSTR4 SSTR1	3.71e-04	31	21	2	CID000119196
Drug	111In-pentetreotide	SSTR4 SSTR1	3.71e-04	31	21	2	CID003081912
Drug	Anidulafungin	DRD1 ATP6V0A1 HTR2B	3.91e-04	157	21	3	CID000166548
Drug	YM-09151-2	DRD1 HTR2B	3.95e-04	32	21	2	CID000004452
Drug	mesoridazine	DRD1 HTR2B	4.20e-04	33	21	2	CID000004078
Drug	CGS 8216	SSTR4 SSTR1	4.20e-04	33	21	2	CID000104916
Drug	pirenperone	DRD1 HTR2B	4.20e-04	33	21	2	CID000004847
Drug	Depixol	DRD1 HTR2B	4.20e-04	33	21	2	CID000017011
Drug	ropinirole	DRD1 HTR2B	4.20e-04	33	21	2	CID000005095
Drug	transdihydrolisuride	DRD1 HTR2B	4.47e-04	34	21	2	CID000005406
Drug	CGS 12066B	DRD1 HTR2B	4.47e-04	34	21	2	CID000002689
Drug	Amitriptyline	CASR DRD1 SSTR1	4.52e-04	165	21	3	ctd:D000639
Disease	MHPG measurement, 5-HIAA measurement	PIEZO2 SSTR1	6.52e-05	17	21	2	EFO_0005132, EFO_0005133
Disease	Parkinson's disease (implicated_via_orthology)	SSTR4 DRD1 SSTR1	1.83e-04	157	21	3	DOID:14330 (implicated_via_orthology)
Disease	neutrophil count, eosinophil count	ABCA7 NLRP3 SCD5	4.48e-04	213	21	3	EFO_0004833, EFO_0004842
Disease	neutrophil percentage of leukocytes	ABCA7 C3AR1 NLRP3 SCD5	8.18e-04	610	21	4	EFO_0007990
Disease	Petit mal status	SSTR4 SSTR1	1.04e-03	67	21	2	C0270823
Disease	Status Epilepticus, Subclinical	SSTR4 SSTR1	1.04e-03	67	21	2	C0751522
Disease	Simple Partial Status Epilepticus	SSTR4 SSTR1	1.04e-03	67	21	2	C0751524
Disease	Non-Convulsive Status Epilepticus	SSTR4 SSTR1	1.04e-03	67	21	2	C0751523
Disease	Grand Mal Status Epilepticus	SSTR4 SSTR1	1.04e-03	67	21	2	C0311335
Disease	Complex Partial Status Epilepticus	SSTR4 SSTR1	1.04e-03	67	21	2	C0393734
Disease	Status Epilepticus	SSTR4 SSTR1	1.07e-03	68	21	2	C0038220
Disease	Amphetamine Abuse	PROKR2 DRD1	1.30e-03	75	21	2	C0236807

Protein segments in the cluster

Peptide	Gene	Start	Entry
MWCPFFITNITLVLC	HTR2B	336	P41595
CTFMQIVICVIWLYT	CASR	731	P41180
VIMGVFVCCWLPFFI	DRD1	276	P21728
IWVVAFVMCIPVFVY	C3AR1	146	Q16581
WDMCNYLVPACIVVL	ABCA7	1586	Q8IZY2
NTILFSMCRVPVVCW	NLRP8	386	Q86W28
ILYKACQVPGICWVV	NLRP10	346	Q86W26
VGCLCVVYVLVVIWA	PKD1L2	1351	Q7Z442
IFTFLVCWMPYIVIC	OPN3	261	Q9H1Y3
VCWMPYIVICFLVVN	OPN3	266	Q9H1Y3
VILMIPIAVCIYWIN	BTN2A1	256	Q7KYR7
FTMCFIPLVCWIVCT	NLRP3	406	Q96P20
VICWMPFYVVQLVNV	SSTR1	281	P30872
LWMVCTVLAVFIICF	PTAFR	231	P25105
VVFVLCWMPFYVVQL	SSTR4	266	P31391
VVLMCFVVPTLVPWY	SCD5	196	Q86SK9
CTVWTCVIIVCKMLY	PIEZO2	986	Q9H5I5
VLMCILTAYVLCWAP	PROKR2	276	Q8NFJ6
QCFLVVVALLCVPWM	ATP6V0A1	636	Q93050
CWVLYLDPTLCVVMV	SLC30A1	311	Q9Y6M5
KGILCMFPWQCVVYV	PRO1933	46	Q9H354
LVPYLVCFMWCELSV	WFS1	531	O76024
CFAIVNVVCFIQPYW	LHFPL3	46	Q86UP9