Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol-3-phosphate binding

ZFYVE26 ZFYVE1

1.77e-0348262GO:0032266
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

DHX15 ERAS EFL1 DHX8 ENTPD3

2.90e-03775265GO:0017111
GeneOntologyMolecularFunctionpyrophosphatase activity

DHX15 ERAS EFL1 DHX8 ENTPD3

4.08e-03839265GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

DHX15 ERAS EFL1 DHX8 ENTPD3

4.10e-03840265GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

DHX15 ERAS EFL1 DHX8 ENTPD3

4.10e-03840265GO:0016818
GeneOntologyMolecularFunctionRNA helicase activity

DHX15 DHX8

4.61e-0378262GO:0003724
GeneOntologyMolecularFunctionATP-dependent activity, acting on RNA

DHX15 DHX8

4.84e-0380262GO:0008186
GeneOntologyBiologicalProcessregulation of cytokinesis

PRKCE ZFYVE26 ATXN10 KLHL9

6.88e-0699264GO:0032465
GeneOntologyBiologicalProcessregulation of cell division

PRKCE ZFYVE26 ATXN10 KLHL9

1.11e-04201264GO:0051302
GeneOntologyBiologicalProcesscytokinesis

PRKCE ZFYVE26 ATXN10 KLHL9

1.17e-04204264GO:0000910
DomainDUF1605

DHX15 DHX8

2.31e-0417252IPR011709
DomainOB_NTP_bind

DHX15 DHX8

2.31e-0417252PF07717
DomainHA2

DHX15 DHX8

2.60e-0418252PF04408
DomainHelicase-assoc_dom

DHX15 DHX8

2.60e-0418252IPR007502
DomainHA2

DHX15 DHX8

2.60e-0418252SM00847
Domain-

KLHL9 KLHL8

5.92e-04272522.130.10.80
DomainFYVE

ZFYVE26 ZFYVE1

6.83e-0429252PF01363
DomainFYVE

ZFYVE26 ZFYVE1

6.83e-0429252SM00064
DomainZnf_FYVE-rel

ZFYVE26 ZFYVE1

9.40e-0434252IPR017455
DomainGal_Oxidase_b-propeller

KLHL9 KLHL8

9.40e-0434252IPR015916
DomainDNA/RNA_helicase_DEAH_CS

DHX15 DHX8

9.96e-0435252IPR002464
DomainZnf_FYVE

ZFYVE26 ZFYVE1

1.17e-0338252IPR000306
DomainDEAH_ATP_HELICASE

DHX15 DHX8

1.17e-0338252PS00690
DomainZF_FYVE

ZFYVE26 ZFYVE1

1.30e-0340252PS50178
DomainBTB-kelch_protein

KLHL9 KLHL8

1.50e-0343252IPR017096
DomainKelch

KLHL9 KLHL8

2.72e-0358252SM00612
Domain-

DHX15 ERAS EFL1 ZFYVE1 DHX8

2.74e-037462553.40.50.300
DomainGal_Oxase/kelch_b-propeller

KLHL9 KLHL8

2.81e-0359252IPR011043
DomainBACK

KLHL9 KLHL8

2.90e-0360252SM00875
DomainBACK

KLHL9 KLHL8

3.00e-0361252PF07707
DomainBACK

KLHL9 KLHL8

3.00e-0361252IPR011705
DomainKelch_1

KLHL9 KLHL8

3.93e-0370252PF01344
DomainKelch_1

KLHL9 KLHL8

3.93e-0370252IPR006652
DomainDEAD

DHX15 DHX8

4.26e-0373252PF00270
DomainDEAD/DEAH_box_helicase_dom

DHX15 DHX8

4.26e-0373252IPR011545
DomainP-loop_NTPase

DHX15 ERAS EFL1 ZFYVE1 DHX8

4.75e-03848255IPR027417
DomainHelicase_C

DHX15 DHX8

8.95e-03107252PF00271
DomainHELICc

DHX15 DHX8

8.95e-03107252SM00490
DomainHelicase_C

DHX15 DHX8

9.11e-03108252IPR001650
DomainHELICASE_CTER

DHX15 DHX8

9.28e-03109252PS51194
DomainHELICASE_ATP_BIND_1

DHX15 DHX8

9.28e-03109252PS51192
DomainDEXDc

DHX15 DHX8

9.28e-03109252SM00487
DomainHelicase_ATP-bd

DHX15 DHX8

9.44e-03110252IPR014001
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

BEND3 PRPF38B KLHL9 SUPT20H KLHL8 SND1 DHX8 NUP205

4.65e-07100526819615732
Pubmed

Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22.

DHX15 DHX8

5.37e-0722627935475
Pubmed

Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43.

DHX15 DHX8

3.22e-0642629342318
Pubmed

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

BCAT2 EFL1 ZFYVE26

4.81e-064426327534441
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

DHX15 EFL1 PRPF38B ATXN10 SUPT20H SND1 NUP205

7.10e-06101426732416067
Pubmed

The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity.

DHX15 DHX8

1.50e-05826235263596
Pubmed

A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.

KLHL9 KLHL8 PIK3R3

3.39e-058426334591642
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

DHX15 BEND3 SND1 DHX8 NUP205

1.09e-0465326522586326
Pubmed

A novel missense variant in CUL3 shows altered binding ability to BTB-adaptor proteins leading to diverse phenotypes of CUL3-related disorders.

KLHL9 KLHL8

1.35e-042326233130828
Pubmed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

DHX15 KLHL9 PIK3R3 DHX8

1.46e-0436326425036637
Pubmed

β-dystroglycan is regulated by a balance between WWP1-mediated degradation and protection from WWP1 by dystrophin and utrophin.

ATXN10 SND1

1.47e-042426229635000
Pubmed

Dimerization quality control ensures neuronal development and survival.

KLHL9 KLHL8

1.47e-042426230190310
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

DHX15 PRPF38B SND1 MRPL1 DHX8

1.64e-0471326529802200
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

DHX15 KLHL9 SND1 DHX8

4.11e-0447726431300519
Pubmed

Update on the Kelch-like (KLHL) gene family.

KLHL9 KLHL8

4.33e-044126223676014
Pubmed

The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.

DHX15 SND1 NUP205

5.83e-0422026334091597
GeneFamilyDEAH-box helicases

DHX15 DHX8

1.53e-0416212500
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

ZFYVE26 ZFYVE1

5.85e-043121281
GeneFamilyKelch like|BTB domain containing

KLHL9 KLHL8

1.08e-0342212617
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

BCAT2 HMHB1

1.58e-0351212870
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KLHL9 KLHL8

1.04e-02134212861
Diseaselifestyle measurement, alcohol consumption measurement

DHX8 ENTPD3 NUP205

1.25e-04115253EFO_0007878, EFO_0010724
Diseaseaspartate aminotransferase measurement

DHX15 ANO5 KLHL8 SND1 IGHG3

8.51e-04904255EFO_0004736
Diseasecorpus callosum posterior volume measurement

PRKCE SND1

8.90e-0452252EFO_0010298
Diseaseneuroimaging measurement, brain volume measurement

BEND3 ATXN10 PIK3R3

1.77e-03286253EFO_0004346, EFO_0006930
Diseasebody weight

ADAMTS10 PRKCE ANO5 ATXN10 ZFYVE1

3.68e-031261255EFO_0004338
Diseaseattention deficit hyperactivity disorder, autism spectrum disorder, intelligence

EFL1 SND1 ZFYVE1

4.49e-03398253EFO_0003756, EFO_0003888, EFO_0004337

Protein segments in the cluster

PeptideGeneStartEntry
VKIHAPWEVLVTYAE

ANO5

131

Q75V66
WIRHPEKYMEEIVES

TBC1D32

306

Q96NH3
PVWKEHFLFEIEDVS

BAIAP3

271

O94812
IDVIDAYQKHPESEW

ATXN10

201

Q9UBB4
WVPTTEEEYLHFGEK

EFL1

1066

Q7Z2Z2
VLDHKPEWVLYNEFV

DHX15

726

O43143
YEDVVWIPKGSVHIF

ADAMTS10

721

Q9H324
YKFTEETWPQIHFEK

ENTPD3

436

O75355
FVEDHDPTIQDSYWK

ERAS

66

Q7Z444
AEKWEVAEVVLEVFY

NUP205

756

Q92621
EKMEEVWHYECIPSI

BEND3

791

Q5T5X7
HDDVLYPVWLSKEAV

PRKCE

621

Q02156
SVERYDPHLDKWIEV

KLHL8

476

Q9P2G9
VEIVQKYDPEKDEWH

KLHL9

561

Q9P2J3
HVWKSELVEVEDDVY

HMHB1

16

O97980
PHYDEKTWFVEDINR

PIK3R3

351

Q92569
YFEHVEEAVWAVEVL

BHMT2

151

Q9H2M3
VSHEDPEVQFKWYVD

IGHG3

196

P01860
PEVQFKWYVDGVEVH

IGHG3

201

P01860
FVYWTHEDGVLELVT

BCAT2

271

O15382
PEWVVYHELVLTTKE

DHX8

1146

Q14562
KVWAHYEEQPVEEVM

SND1

656

Q7KZF4
KIWDDEIVADFYVAV

MRPL1

186

Q9BYD6
VDEIYFKVTHVEPWE

PRPF38B

86

Q5VTL8
TVWPAHDVKDDYVFE

SUPT20H

326

Q8NEM7
VWAAYDPVHKVAVID

ZFYVE1

221

Q9HBF4
YSFVVRVPKADEVEW

ZFYVE26

1896

Q68DK2