Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal protein binding	KIF21B CACNB2 SHROOM3 SPIRE2 MTUS1 SYNE1 SVIL MID1 KIF19 TRIOBP STMND1 SORBS1 FHDC1 CCDC61	9.35e-05	1099	79	14	GO:0008092
GeneOntologyMolecularFunction	microtubule binding	KIF21B SPIRE2 MTUS1 MID1 KIF19 FHDC1 CCDC61	2.18e-04	308	79	7	GO:0008017
GeneOntologyMolecularFunction	tubulin binding	KIF21B SPIRE2 MTUS1 MID1 KIF19 STMND1 FHDC1 CCDC61	2.88e-04	428	79	8	GO:0015631
GeneOntologyMolecularFunction	structural constituent of presynaptic active zone	RIMS1 RIMS2	4.26e-04	8	79	2	GO:0098882
GeneOntologyMolecularFunction	actin binding	CACNB2 SHROOM3 SPIRE2 SYNE1 SVIL TRIOBP SORBS1 FHDC1	6.08e-04	479	79	8	GO:0003779
GeneOntologyMolecularFunction	structural constituent of synapse	RIMS1 CTNND2 RIMS2	6.12e-04	42	79	3	GO:0098918
GeneOntologyMolecularFunction	phosphatidylinositol phosphate binding	KCNH1 SVIL SYT10 GAB2 TECPR1	1.16e-03	199	79	5	GO:1901981
GeneOntologyMolecularFunction	signaling receptor complex adaptor activity	IRS1 SORBS1 GAB2	1.28e-03	54	79	3	GO:0030159
GeneOntologyBiologicalProcess	cell morphogenesis	CDKL5 SHROOM3 NEO1 HEG1 CELSR3 RNF6 DSCAM SYNE1 PLXNA4 TRIOBP RIMS1 CTNND2 RIMS2 PIP5K1C NEUROG3	4.78e-05	1194	80	15	GO:0000902
GeneOntologyBiologicalProcess	neuron projection morphogenesis	CDKL5 NEO1 CELSR3 RNF6 DSCAM SYNE1 PLXNA4 RIMS1 CTNND2 RIMS2 PIP5K1C NEUROG3	5.84e-05	802	80	12	GO:0048812
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	CDKL5 NEO1 CELSR3 RNF6 DSCAM SYNE1 PLXNA4 RIMS1 CTNND2 RIMS2 PIP5K1C NEUROG3	7.13e-05	819	80	12	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	CDKL5 NEO1 CELSR3 RNF6 DSCAM SYNE1 PLXNA4 RIMS1 CTNND2 RIMS2 PIP5K1C NEUROG3	7.73e-05	826	80	12	GO:0048858
GeneOntologyBiologicalProcess	synaptic signaling	CDKL5 CACNB2 NEO1 INSYN1 KCNH1 SYNE1 KMT2A SORBS1 RIMS1 CTNND2 RIMS2 PIP5K1C SYT10	9.11e-05	976	80	13	GO:0099536
GeneOntologyBiologicalProcess	calcium ion-regulated exocytosis of neurotransmitter	RIMS1 RIMS2 SYT10	1.22e-04	25	80	3	GO:0048791
GeneOntologyBiologicalProcess	synaptic vesicle exocytosis	KCNH1 RIMS1 RIMS2 PIP5K1C SYT10	1.26e-04	125	80	5	GO:0016079
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	CDKL5 NEO1 CELSR3 RNF6 DSCAM SYNE1 PLXNA4 TRIOBP CTNND2 PIP5K1C NEUROG3	1.42e-04	748	80	11	GO:0048667
GeneOntologyBiologicalProcess	inhibitory postsynaptic potential	INSYN1 RIMS1 RIMS2	1.54e-04	27	80	3	GO:0060080
GeneOntologyBiologicalProcess	neuron projection extension	CDKL5 RNF6 DSCAM PLXNA4 RIMS1 RIMS2	1.54e-04	207	80	6	GO:1990138
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	CDKL5 CACNB2 NEO1 INSYN1 KCNH1 SYNE1 KMT2A RIMS1 CTNND2 RIMS2 PIP5K1C SYT10	2.37e-04	931	80	12	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	CDKL5 CACNB2 NEO1 INSYN1 KCNH1 SYNE1 KMT2A RIMS1 CTNND2 RIMS2 PIP5K1C SYT10	2.37e-04	931	80	12	GO:0007268
GeneOntologyBiologicalProcess	protein depolymerization	SVIL MID1 KIF19 TRIOBP STMND1	2.44e-04	144	80	5	GO:0051261
GeneOntologyBiologicalProcess	trans-synaptic signaling	CDKL5 CACNB2 NEO1 INSYN1 KCNH1 SYNE1 KMT2A RIMS1 CTNND2 RIMS2 PIP5K1C SYT10	2.56e-04	939	80	12	GO:0099537
GeneOntologyBiologicalProcess	supramolecular fiber organization	SHROOM3 SPIRE2 RIPK3 SVIL MID1 KIF19 TRIOBP PRKCD STMND1 SORBS1 FHDC1 CCDC57	3.04e-04	957	80	12	GO:0097435
GeneOntologyBiologicalProcess	regulation of calcium-dependent activation of synaptic vesicle fusion	RIMS1 RIMS2	3.08e-04	7	80	2	GO:0150037
GeneOntologyBiologicalProcess	neuron projection development	CDKL5 NEO1 CELSR3 RNF6 DSCAM SYNE1 PLXNA4 TRIOBP STMND1 RIMS1 CTNND2 RIMS2 PIP5K1C NEUROG3	3.88e-04	1285	80	14	GO:0031175
GeneOntologyBiologicalProcess	regulation of insulin receptor signaling pathway	RPS6KB2 PRKCD IRS1 SORBS1	4.52e-04	92	80	4	GO:0046626
GeneOntologyBiologicalProcess	regulation of regulated secretory pathway	KCNH1 RIMS1 RIMS2 SYT10 GAB2	4.57e-04	165	80	5	GO:1903305
GeneOntologyBiologicalProcess	cilium organization	CDKL5 CELSR3 SYNE1 KIF19 MARCHF7 FHDC1 TMEM80 CCDC57	5.14e-04	476	80	8	GO:0044782
GeneOntologyCellularComponent	asymmetric synapse	CDKL5 NEO1 CELSR3 INSYN1 KCNH1 PLXNA4 RIMS1 CTNND2 PIP5K1C	8.59e-05	477	80	9	GO:0032279
GeneOntologyCellularComponent	neuron to neuron synapse	CDKL5 NEO1 CELSR3 INSYN1 KCNH1 PLXNA4 RIMS1 CTNND2 PIP5K1C	1.72e-04	523	80	9	GO:0098984
GeneOntologyCellularComponent	microtubule organizing center	CDKL5 MTUS1 MID1 TRIOBP MARCHF7 IRS1 SORBS1 TOPORS CCDC57 CCDC61 LUZP1 SMTNL2	1.86e-04	919	80	12	GO:0005815
GeneOntologyCellularComponent	postsynaptic density	CDKL5 NEO1 CELSR3 INSYN1 KCNH1 RIMS1 CTNND2 PIP5K1C	3.29e-04	451	80	8	GO:0014069
GeneOntologyCellularComponent	cytoskeleton of presynaptic active zone	RIMS1 RIMS2	3.99e-04	8	80	2	GO:0048788
GeneOntologyCellularComponent	postsynapse	KIF21B CDKL5 NEO1 CELSR3 INSYN1 KCNH1 SYNE1 EIF4G1 PRKCD RIMS1 CTNND2 PIP5K1C	4.71e-04	1018	80	12	GO:0098794
GeneOntologyCellularComponent	postsynaptic specialization	CDKL5 NEO1 CELSR3 INSYN1 KCNH1 RIMS1 CTNND2 PIP5K1C	6.76e-04	503	80	8	GO:0099572
GeneOntologyCellularComponent	microtubule	KIF21B SHROOM3 MTUS1 SVIL MID1 KIF19 FHDC1 CCDC57	9.83e-04	533	80	8	GO:0005874
GeneOntologyCellularComponent	glutamatergic synapse	KIF21B CDKL5 NEO1 CELSR3 PLXNA4 RIMS1 CTNND2 RIMS2 PIP5K1C SYT10	1.09e-03	817	80	10	GO:0098978
GeneOntologyCellularComponent	presynaptic cytoskeleton	RIMS1 RIMS2	1.28e-03	14	80	2	GO:0099569
Domain	-	SPIRE2 RNF6 MID1 RLIM KMT2A MARCHF7 SCAF11 RIMS1 TOPORS RIMS2 DNMT3B	2.20e-06	449	77	11	3.30.40.10
Domain	Znf_RING/FYVE/PHD	SPIRE2 RNF6 MID1 RLIM KMT2A MARCHF7 SCAF11 RIMS1 TOPORS RIMS2 DNMT3B	2.72e-06	459	77	11	IPR013083
Domain	MA3	EIF4G1 CWC22	2.49e-04	6	77	2	SM00544
Domain	MA3	EIF4G1 CWC22	2.49e-04	6	77	2	PF02847
Domain	MI	EIF4G1 CWC22	2.49e-04	6	77	2	PS51366
Domain	Initiation_fac_eIF4g_MI	EIF4G1 CWC22	2.49e-04	6	77	2	IPR003891
Domain	C2	PRKCD RIMS1 RIMS2 SYT10 RASAL2	2.55e-04	137	77	5	SM00239
Domain	C2	PRKCD RIMS1 RIMS2 SYT10 RASAL2	3.01e-04	142	77	5	PS50004
Domain	Znf_FYVE_PHD	SPIRE2 KMT2A RIMS1 RIMS2 DNMT3B	3.53e-04	147	77	5	IPR011011
Domain	-	PRKCD RIMS1 RIMS2 SYT10 RASAL2	3.65e-04	148	77	5	2.60.40.150
Domain	C2_dom	PRKCD RIMS1 RIMS2 SYT10 RASAL2	5.83e-04	164	77	5	IPR000008
Domain	MIF4G	EIF4G1 CWC22	7.39e-04	10	77	2	SM00543
Domain	MIF4G	EIF4G1 CWC22	7.39e-04	10	77	2	PF02854
Domain	MIF4G-like_typ-3	EIF4G1 CWC22	7.39e-04	10	77	2	IPR003890
Domain	FYVE_2	RIMS1 RIMS2	9.01e-04	11	77	2	PF02318
Domain	FN3	NEO1 DSCAM MID1 ASTN2 FNDC3A	1.00e-03	185	77	5	SM00060
Domain	PH	TRIOBP IRS1 ARHGEF3 RASAL2 GAB2 TECPR1	1.01e-03	278	77	6	SM00233
Domain	PH_DOMAIN	TRIOBP IRS1 ARHGEF3 RASAL2 GAB2 TECPR1	1.03e-03	279	77	6	PS50003
Domain	PH_domain	TRIOBP IRS1 ARHGEF3 RASAL2 GAB2 TECPR1	1.05e-03	280	77	6	IPR001849
Domain	RABBD	RIMS1 RIMS2	1.08e-03	12	77	2	PS50916
Domain	Rab_BD	RIMS1 RIMS2	1.08e-03	12	77	2	IPR010911
Domain	zf-RING_2	RNF6 RLIM SCAF11	1.29e-03	52	77	3	PF13639
Domain	FN3	NEO1 DSCAM MID1 ASTN2 FNDC3A	1.39e-03	199	77	5	PS50853
Domain	MIF4-like	EIF4G1 CWC22	1.70e-03	15	77	2	IPR016021
Domain	-	EIF4G1 CWC22	1.70e-03	15	77	2	1.25.40.180
Domain	FN3_dom	NEO1 DSCAM MID1 ASTN2 FNDC3A	1.72e-03	209	77	5	IPR003961
Domain	C2	RIMS1 RIMS2 SYT10 RASAL2	2.11e-03	131	77	4	PF00168
Domain	Znf_RING	RNF6 MID1 RLIM MARCHF7 SCAF11 TOPORS	2.26e-03	326	77	6	IPR001841
Domain	zf-C3HC4	RNF6 MID1 RLIM MARCHF7 TOPORS	2.28e-03	223	77	5	PF00097
Domain	PDZ	SHROOM3 CNKSR3 RIMS1 RIMS2	2.75e-03	141	77	4	PF00595
Domain	PDZ	SHROOM3 CNKSR3 RIMS1 RIMS2	3.27e-03	148	77	4	SM00228
Domain	-	SHROOM3 CNKSR3 RIMS1 RIMS2	3.43e-03	150	77	4	2.30.42.10
Domain	PDZ	SHROOM3 CNKSR3 RIMS1 RIMS2	3.52e-03	151	77	4	PS50106
Domain	PDZ	SHROOM3 CNKSR3 RIMS1 RIMS2	3.60e-03	152	77	4	IPR001478
Domain	PWWP	PWWP3A DNMT3B	4.01e-03	23	77	2	PF00855
Domain	PWWP_dom	PWWP3A DNMT3B	4.01e-03	23	77	2	IPR000313
Domain	PWWP	PWWP3A DNMT3B	4.37e-03	24	77	2	PS50812
Domain	fn3	NEO1 DSCAM MID1 FNDC3A	4.52e-03	162	77	4	PF00041
Domain	-	TRIOBP IRS1 ARHGEF3 RASAL2 GAB2 TECPR1	5.51e-03	391	77	6	2.30.29.30
Domain	Znf_C3HC4_RING-type	RNF6 RLIM MARCHF7 TOPORS	5.58e-03	172	77	4	IPR018957
Domain	ZF_RING_1	RNF6 MID1 RLIM SCAF11 TOPORS	7.03e-03	291	77	5	PS00518
Domain	ZF_RING_2	RNF6 MID1 RLIM SCAF11 TOPORS	7.75e-03	298	77	5	PS50089
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	USP31 SHROOM3 SPIRE2 MTUS1 SVIL CNKSR3 EIF4G1 SPATA18 KMT2A IRS1 SORBS1 LARP1B SRRM2 RASAL2 LUZP1 GAB2	1.07e-10	861	80	16	36931259
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KIF21B CACNB2 SHROOM3 DSCAM SYNE1 SVIL CNKSR3 EIF4G1 TRIOBP SORBS1 RIMS1 CTNND2 AFF4 RASAL2 LUZP1	4.80e-09	963	80	15	28671696
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KANSL1 SGTA SVIL EIF4G1 USP24 MKI67 KMT2A ACIN1 PRKCD SCAF11 RIMS1 TOPORS SRRM2	2.38e-08	774	80	13	15302935
Pubmed	Thalamocortical control of cell-type specificity drives circuits for processing whisker-related information in mouse barrel cortex.	CELSR3 RIMS1 RIMS2	1.17e-07	5	80	3	37770450
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	CACNB2 SYNE1 SORBS1 RIMS1 CTNND2 RIMS2 RASAL2 LUZP1	2.88e-07	281	80	8	28706196
Pubmed	Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.	KIF21B CACNB2 SYNE1 KMT2A SLC45A1	4.21e-07	65	80	5	23453885
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NFE2L3 SARS2 CELSR3 DSCAM RBL2 SYNE1 SGTA EIF4G1 TRIOBP ASTN2 SORBS1 CTNND2 AFF4 RASAL2	1.27e-06	1285	80	14	35914814
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIF21B SHROOM3 CELSR3 MTUS1 TRIOBP FNDC3A SCAF11 RIMS2 CWC22	3.62e-06	529	80	9	14621295
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	USP31 HEG1 KANSL1 MTUS1 SYNE1	4.16e-06	103	80	5	10574462
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	USP31 CDKL5 CACNB2 SYNE1 SVIL EIF4G1 SCAPER PLXNA4 KMT2A SORBS1 RIMS1 CTNND2 RASAL2 LUZP1	4.43e-06	1431	80	14	37142655
Pubmed	Retinoic acid mediates degradation of IRS-1 by the ubiquitin-proteasome pathway, via a PKC-dependant mechanism.	PRKCD IRS1	5.23e-06	2	80	2	15516986
Pubmed	RIM2α is a molecular scaffold for Zona pellucida-induced acrosome reaction.	RIMS1 RIMS2	5.23e-06	2	80	2	25240052
Pubmed	Analysis of RIM Expression and Function at Mouse Photoreceptor Ribbon Synapses.	RIMS1 RIMS2	5.23e-06	2	80	2	28701482
Pubmed	RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes.	RIMS1 RIMS2	5.23e-06	2	80	2	29606581
Pubmed	RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors.	RIMS1 RIMS2	5.23e-06	2	80	2	26400943
Pubmed	A presynaptic phosphosignaling hub for lasting homeostatic plasticity.	RIMS1 RIMS2	5.23e-06	2	80	2	35443170
Pubmed	Recent ultra-rare inherited variants implicate new autism candidate risk genes.	DSCAM KCNH1	5.23e-06	2	80	2	34312540
Pubmed	Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta.	PRKCD IRS1	5.23e-06	2	80	2	14583092
Pubmed	RIM genes differentially contribute to organizing presynaptic release sites.	RIMS1 RIMS2	5.23e-06	2	80	2	22753485
Pubmed	Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysms via smooth muscle cell necrosis and inflammation.	RIPK3 PRKCD	5.23e-06	2	80	2	25563840
Pubmed	The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus.	RIMS1 RIMS2	5.23e-06	2	80	2	22956829
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	MKI67 SORBS1 RIMS1 CTNND2 RIMS2	1.20e-05	128	80	5	30995482
Pubmed	Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.	CELSR3 MKI67 CWC22 NEUROG3	1.39e-05	63	80	4	25053427
Pubmed	Predicting Lymph Node Metastasis in Endometrial Cancer Using Serum CA125 Combined with Immunohistochemical Markers PR and Ki67, and a Comparison with Other Prediction Models.	MKI67 MUC16	1.57e-05	3	80	2	27163153
Pubmed	RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone.	RIMS1 RIMS2	1.57e-05	3	80	2	21262468
Pubmed	Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones.	RIMS1 RIMS2	1.57e-05	3	80	2	26034270
Pubmed	C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 α1 subunits are differentially regulated by Rab3-interacting molecule proteins.	RIMS1 RIMS2	1.57e-05	3	80	2	28377503
Pubmed	RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction.	RIMS1 RIMS2	1.57e-05	3	80	2	21241895
Pubmed	Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells.	PRKCD IRS1	1.57e-05	3	80	2	18285345
Pubmed	RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse.	RIMS1 RIMS2	1.57e-05	3	80	2	25343783
Pubmed	RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain.	RIMS1 RIMS2	1.57e-05	3	80	2	31486769
Pubmed	Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.	RIMS1 RIMS2	1.57e-05	3	80	2	25730884
Pubmed	Alternative splicing in the first alpha-helical region of the Rab-binding domain of Rim regulates Rab3A binding activity: is Rim a Rab3 effector protein during evolution?	RIMS1 RIMS2	1.57e-05	3	80	2	15330860
Pubmed	The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones.	RNF6 RLIM	1.57e-05	3	80	2	16204183
Pubmed	Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex.	RIMS1 RIMS2	1.57e-05	3	80	2	25155955
Pubmed	AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23).	KMT2A AFF4	1.57e-05	3	80	2	10588740
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	SORBS1 RIMS1 CTNND2 RIMS2 SRRM2 LUZP1	1.60e-05	231	80	6	16452087
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	KIF21B SVIL SORBS1 CTNND2	1.78e-05	67	80	4	29254152
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	CDKL5 MTUS1 SVIL MKI67 TRIOBP ACIN1 SRRM2	2.03e-05	361	80	7	30344098
Pubmed	Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification.	CELSR3 MKI67 PLXNA4 KMT2A	3.09e-05	77	80	4	29445148
Pubmed	Protein composition of axonal dopamine release sites in the striatum.	RIMS1 RIMS2	3.13e-05	4	80	2	36579890
Pubmed	Divergent properties and independent regulation of striatal dopamine and GABA co-transmission.	RIMS1 RIMS2	3.13e-05	4	80	2	35584679
Pubmed	RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13.	RIMS1 RIMS2	3.13e-05	4	80	2	21262469
Pubmed	Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins.	RIMS1 RIMS2	3.13e-05	4	80	2	12620390
Pubmed	Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions.	RNF6 RLIM	3.13e-05	4	80	2	12874135
Pubmed	Recurrent CNVs disrupt three candidate genes in schizophrenia patients.	ASTN2 CTNND2	3.13e-05	4	80	2	18940311
Pubmed	Rab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels.	RIMS1 RIMS2	3.13e-05	4	80	2	20452978
Pubmed	Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).	PRKCD IRS1	3.13e-05	4	80	2	15364919
Pubmed	Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.	RIMS1 RIMS2	3.13e-05	4	80	2	27537483
Pubmed	Genetic mapping of eight SH3 domain genes on seven mouse chromosomes.	CACNB2 FNDC3A SORBS1	3.68e-05	28	80	3	10087302
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP31 KANSL1 SYNE1 ACIN1 SORBS1 SRRM2 PIP5K1C	4.35e-05	407	80	7	12693553
Pubmed	pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development.	RBL2 MKI67 NEUROG3	4.55e-05	30	80	3	17257418
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	BNC2 RIPK3 RBL2 MID1 RLIM MTPAP	4.99e-05	283	80	6	21903422
Pubmed	Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.	RIMS1 RIMS2	5.20e-05	5	80	2	12871946
Pubmed	RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation.	RIMS1 RIMS2	5.20e-05	5	80	2	28607399
Pubmed	A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.	RIMS1 RIMS2	5.20e-05	5	80	2	32755572
Pubmed	Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex.	RIMS1 RIMS2	5.20e-05	5	80	2	22553025
Pubmed	Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.	RIMS1 RIMS2	5.20e-05	5	80	2	33139401
Pubmed	Actin cytoskeletal association of cytohesin-1 is regulated by specific phosphorylation of its carboxyl-terminal polybasic domain.	PRKCD RIMS1	5.20e-05	5	80	2	11438522
Pubmed	Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling.	PRKCD IRS1	5.20e-05	5	80	2	12031982
Pubmed	Biallelic variants in TSPOAP1, encoding the active-zone protein RIMBP1, cause autosomal recessive dystonia.	RIMS1 RIMS2	5.20e-05	5	80	2	33539324
Pubmed	An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.	RIMS1 RIMS2	5.20e-05	5	80	2	34706221
Pubmed	Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ.	MKI67 DNMT3B	5.20e-05	5	80	2	28425913
Pubmed	RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.	RIMS1 RIMS2	5.20e-05	5	80	2	22248876
Pubmed	Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.	CELSR3 MKI67 NEUROG3	5.54e-05	32	80	3	23177622
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	EIF4G1 MKI67 KMT2A ACIN1 SCAF11 FANCM SRRM2 CWC22 AFF4 LUZP1	6.68e-05	954	80	10	36373674
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CDKL5 SHROOM3 NEO1 DSCAM MKI67 MUC16 PWWP3A RASAL2 GAB2	7.46e-05	777	80	9	35844135
Pubmed	cAMP-GEFII is a direct target of cAMP in regulated exocytosis.	RIMS1 RIMS2	7.79e-05	6	80	2	11056535
Pubmed	Recovery from diabetes in mice by beta cell regeneration.	MKI67 NEUROG3	7.79e-05	6	80	2	17786244
Pubmed	Sex-specific differences in mouse DMRT1 expression are both cell type- and stage-dependent during gonad development.	MKI67 NEUROG3	7.79e-05	6	80	2	17567962
Pubmed	The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators.	RIMS1 RIMS2	7.79e-05	6	80	2	31679900
Pubmed	Genetic analysis of DSCAM's role as a Netrin-1 receptor in vertebrates.	NEO1 DSCAM	7.79e-05	6	80	2	22238077
Pubmed	How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.	RIMS1 RIMS2	7.79e-05	6	80	2	27537484
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	BNC2 CACNB2 DSCAM MTUS1	8.94e-05	101	80	4	18519826
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	MKI67 KMT2A ACIN1 CWC22	9.65e-05	103	80	4	32744500
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	NFE2L3 CACNB2 DSCAM ASTN2 SORBS1 FHDC1 ARHGEF3 NAALADL2 RASAL2	1.06e-04	814	80	9	23251661
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	DSCAM EIF4G1 KMT2A ACIN1 SCAF11	1.06e-04	202	80	5	24639526
Pubmed	Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.	RIMS1 RIMS2	1.09e-04	7	80	2	36398873
Pubmed	Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.	RIMS1 RIMS2	1.09e-04	7	80	2	29398114
Pubmed	Rebuilding essential active zone functions within a synapse.	RIMS1 RIMS2	1.09e-04	7	80	2	35176221
Pubmed	MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation.	MKI67 NEUROG3	1.09e-04	7	80	2	24114270
Pubmed	Glial cell line-derived neurotrophic factor enhances neurogenin3 gene expression and beta-cell proliferation in the developing mouse pancreas.	MKI67 NEUROG3	1.09e-04	7	80	2	20448145
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	NFE2L3 SYNE1 CNKSR3 EIF4G1 PLXNA4 KMT2A ACIN1 RIMS1 RIMS2 CCDC57 LUZP1 DNMT3B	1.09e-04	1442	80	12	35575683
Pubmed	Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.	KMT2A ACIN1 SRRM2	1.26e-04	42	80	3	35705031
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	RNF6 SVIL EIF4G1 MKI67 ACIN1 IRS1 TOPORS SRRM2 MTPAP AFF4 LUZP1	1.31e-04	1247	80	11	27684187
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	MKI67 KMT2A ACIN1 PRKCD SRRM2 AFF4	1.39e-04	341	80	6	32971831
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	KIF21B SVIL EIF4G1 MKI67 ACIN1 SRRM2 CWC22 LUZP1	1.41e-04	660	80	8	32780723
Pubmed	High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism.	MKI67 PRKCD	1.45e-04	8	80	2	15068794
Pubmed	Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.	RNF6 SORBS1	1.45e-04	8	80	2	22905720
Pubmed	OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.	MKI67 NEUROG3	1.45e-04	8	80	2	19882138
Pubmed	REST is a major negative regulator of endocrine differentiation during pancreas organogenesis.	MKI67 NEUROG3	1.45e-04	8	80	2	34385258
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	USP31 SHROOM3 NEO1 SARS2 SYNE1 SGTA TRIOBP FNDC3A SRRM2 CCDC61 RASAL2 LRRC41	1.46e-04	1487	80	12	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CACNB2 SHROOM3 SGTA TRIOBP ASTN2 SCAF11 RIMS1 TAFA5 CCDC57 NAALADL2 AFF4 LRRC41	1.48e-04	1489	80	12	28611215
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	EIF4G1 MKI67 TRIOBP LUZP1	1.63e-04	118	80	4	30979931
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	SVIL EIF4G1 TRIOBP ACIN1 SRRM2 LUZP1	1.86e-04	360	80	6	33111431
Pubmed	MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.	MKI67 NEUROG3	1.86e-04	9	80	2	16443760
Pubmed	Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1.	MKI67 NEUROG3	1.86e-04	9	80	2	31519700
Pubmed	Expression analysis of the Islet-1 gene in the developing and adult gastrointestinal tract.	MKI67 NEUROG3	1.86e-04	9	80	2	21220053
Pubmed	Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses.	RPS6KB2 EIF4G1	1.86e-04	9	80	2	22586265
Pubmed	Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.	RPS6KB2 ANKS4B FANCM AFF4 SMTNL2	1.94e-04	230	80	5	29513927
Interaction	YWHAH interactions	KIF21B USP31 SHROOM3 SPIRE2 MTUS1 RPS6KB2 SVIL CNKSR3 EIF4G1 SPATA18 KMT2A IRS1 SORBS1 RIMS1 LARP1B RIMS2 SRRM2 CWC22 RASAL2 LUZP1 GAB2 SMTNL2	1.80e-10	1102	80	22	int:YWHAH
Interaction	YWHAG interactions	KIF21B USP31 SHROOM3 SPIRE2 MTUS1 SVIL CNKSR3 EIF4G1 SPATA18 USP24 KMT2A ACIN1 PRKCD SCAF11 IRS1 SORBS1 LARP1B SRRM2 CWC22 RASAL2 LUZP1 GAB2 SMTNL2	3.02e-10	1248	80	23	int:YWHAG
Interaction	YWHAB interactions	KIF21B USP31 SHROOM3 SPIRE2 SGTA SVIL CNKSR3 EIF4G1 SPATA18 KMT2A PRKCD IRS1 SORBS1 SRRM2 RASAL2 LUZP1 GAB2 SMTNL2	6.76e-08	1014	80	18	int:YWHAB
Interaction	SFN interactions	MAGEA1 USP31 SHROOM3 SPIRE2 MTUS1 SVIL EIF4G1 KMT2A IRS1 SORBS1 SRRM2 RASAL2 LUZP1 GAB2 SMTNL2	7.82e-08	692	80	15	int:SFN
Interaction	YWHAQ interactions	KIF21B USP31 SHROOM3 SPIRE2 MTUS1 RPS6KB2 SVIL CNKSR3 EIF4G1 SPATA18 KMT2A IRS1 SORBS1 LARP1B RASAL2 LUZP1 GAB2 SMTNL2	2.90e-07	1118	80	18	int:YWHAQ
Interaction	YWHAE interactions	KIF21B USP31 SHROOM3 SPIRE2 SVIL CNKSR3 SPATA18 KMT2A SCAF11 IRS1 SORBS1 RIMS2 SRRM2 RASAL2 LUZP1 GAB2 SMTNL2	6.95e-06	1256	80	17	int:YWHAE
Interaction	DENND2D interactions	ACIN1 SRRM2 CWC22 AFF4	1.23e-05	36	80	4	int:DENND2D
Interaction	YWHAZ interactions	USP31 SHROOM3 SPIRE2 MTUS1 SVIL CNKSR3 SPATA18 KMT2A PRKCD SCAF11 IRS1 SORBS1 RASAL2 LUZP1 GAB2 SMTNL2	5.17e-05	1319	80	16	int:YWHAZ
Interaction	DLGAP1 interactions	CDKL5 SYNE1 CNKSR3 SORBS1 CTNND2 RASAL2	8.12e-05	180	80	6	int:DLGAP1
GeneFamily	Regulating synaptic membrane exocytosis family\|PDZ domain containing	RIMS1 RIMS2	5.23e-05	4	54	2	833
GeneFamily	Fibronectin type III domain containing	NEO1 DSCAM MID1 ASTN2 FNDC3A	1.14e-04	160	54	5	555
GeneFamily	Ring finger proteins	RNF6 MID1 RLIM MARCHF7 SCAF11 TOPORS	1.64e-04	275	54	6	58
GeneFamily	PDZ domain containing	SHROOM3 CNKSR3 RIMS1 RIMS2	1.10e-03	152	54	4	1220
GeneFamily	PWWP domain containing	PWWP3A DNMT3B	1.95e-03	22	54	2	1147
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIOBP IRS1 RASAL2 GAB2	3.32e-03	206	54	4	682
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF21B KIF19	8.33e-03	46	54	2	622
GeneFamily	Ubiquitin specific peptidases	USP31 USP24	1.22e-02	56	54	2	366
Coexpression	CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN	CACNB2 INSYN1 RBL2 CNKSR3 TRIOBP ASTN2 FNDC3A FHDC1 CCDC57 NAALADL2	4.57e-07	407	80	10	M2214
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	HEG1 MTUS1 USP24 MKI67 PRKCD FNDC3A SCAF11 IRS1	3.81e-06	300	80	8	M8702
Coexpression	BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	RNF6 MTUS1 PWWP3A PRKCD MARCHF7 SORBS1 ARHGEF3 TOPORS MTPAP AFF4 RASAL2 DNMT3B	7.11e-06	822	80	12	M6782
Coexpression	LAKE_ADULT_KIDNEY_C15_CONNECTING_TUBULE	SHROOM3 MID1 SCAPER FNDC3A NAALADL2 RASAL2	1.42e-05	171	80	6	M39234
Coexpression	LAKE_ADULT_KIDNEY_C4_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S2	BNC2 SHROOM3 KANSL1 SVIL CNKSR3 RASAL2	1.68e-05	176	80	6	M39223
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HDA	NFE2L3 KIF21B CELSR3 DSCAM PLXNA4 MUC16 RIMS1 ARHGEF3 RIMS2	2.39e-05	506	80	9	M39067
Coexpression	LAKE_ADULT_KIDNEY_C14_DISTAL_CONVOLUTED_TUBULE	SHROOM3 KANSL1 SVIL USP24 SCAPER NAALADL2	4.28e-05	208	80	6	M39233
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HDA1	KIF21B BNC2 DSCAM MID1 SCAPER PLXNA4 RIMS1 ARHGEF3 GAB2	7.23e-05	584	80	9	M39068
Coexpression	DAZARD_UV_RESPONSE_CLUSTER_G6	MTUS1 USP24 MKI67 FNDC3A IRS1	8.33e-05	145	80	5	M1810
Coexpression	LAKE_ADULT_KIDNEY_C17_COLLECTING_SYSTEM_PCS_STRESSED_DISSOC_SUBSET	SHROOM3 MTUS1 MID1 FNDC3A NAALADL2 AFF4	9.45e-05	240	80	6	M39236
CoexpressionAtlas	DevelopingGonad_P2_ovary_emap-30224_top-relative-expression-ranked_1000	BNC2 CACNB2 HEG1 MTUS1 RLIM EIF4G1 SCAPER PLXNA4 ACIN1 SCAF11 RIMS1 LARP1B	2.61e-05	770	79	12	gudmap_developingGonad_P2_ovary_1000
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_1000	BNC2 HEG1 KANSL1 MID1 RLIM EIF4G1 ACIN1 FNDC3A SCAF11 TOPORS CCDC61 RASAL2	3.98e-05	804	79	12	gudmap_developingGonad_e12.5_ovary_1000
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_1000	SHROOM3 CNKSR3 EIF4G1 SCAF11 SORBS1 TAFA5 CTNND2 FANCM TOPORS RIMS2 LUZP1 SMTNL2 DNMT3B	6.94e-05	991	79	13	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_1000
CoexpressionAtlas	dev gonad_e11.5_F_GonMes_Sma_top-relative-expression-ranked_1000	BNC2 CACNB2 SHROOM3 NEO1 KCNH1 RLIM PLXNA4 MUC16 IRS1 TOPORS CWC22 GAB2	7.44e-05	858	79	12	gudmap_dev gonad_e11.5_F_GonMes_Sma_1000
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_1000	BNC2 CACNB2 HEG1 KANSL1 RLIM EIF4G1 SCAPER ACIN1 SCAF11 LARP1B RASAL2	1.39e-04	778	79	11	gudmap_developingGonad_e18.5_ovary_1000
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_500	BNC2 HEG1 KANSL1 MID1 RLIM EIF4G1 ACIN1 SCAF11	1.50e-04	413	79	8	gudmap_developingGonad_e14.5_ epididymis_500
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 CACNB2 SYNE1 PLXNA4 IRS1 RIMS1 SYT10	4.37e-08	185	80	7	e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 KANSL1 MTUS1 USP24 KMT2A ARHGEF3 LUZP1	4.88e-08	188	80	7	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 KANSL1 MTUS1 USP24 KMT2A ARHGEF3 LUZP1	4.88e-08	188	80	7	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	CACNB2 SHROOM3 SVIL MID1 SORBS1 RIMS1 RASAL2	4.88e-08	188	80	7	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 KANSL1 MTUS1 USP24 KMT2A ARHGEF3 LUZP1	4.88e-08	188	80	7	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 CACNB2 MTUS1 PLXNA4 IRS1 RIMS1 SYT10	4.88e-08	188	80	7	293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	CACNB2 MTUS1 SYNE1 SVIL PLXNA4 IRS1 SYT10	7.45e-08	200	80	7	9d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCell	droplet-Thymus-nan-3m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB2 CELSR3 MTUS1 PLXNA4 CTNND2 GAB2	7.03e-07	173	80	6	63f03abca84ae021ff34ff34537838aa8a1ccd11
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 CACNB2 MTUS1 PLXNA4 IRS1 RIMS1	1.04e-06	185	80	6	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 CACNB2 MTUS1 IRS1 RIMS1 SYT10	1.07e-06	186	80	6	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 CACNB2 SYNE1 PLXNA4 IRS1 SYT10	1.14e-06	188	80	6	3177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 CACNB2 SYNE1 IRS1 RIMS1 SYT10	1.18e-06	189	80	6	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	Control-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	SHROOM3 MTUS1 SYNE1 CNKSR3 SORBS1 FHDC1	1.29e-06	192	80	6	1bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NEO1 SVIL IRS1 SORBS1 RIMS1 SYT10	1.41e-06	195	80	6	eb2003d4f15cad213d17eda8ab7479f5a0c62164
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MTUS1 SYNE1 SVIL PLXNA4 IRS1 SYT10	1.59e-06	199	80	6	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	CACNB2 MTUS1 SYNE1 SVIL IRS1 SYT10	1.64e-06	200	80	6	c5e051f1aac8dda376c342a9932785a23450e073
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CACNB2 MTUS1 SYNE1 PLXNA4 IRS1 SYT10	1.64e-06	200	80	6	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KANSL1 KMT2A ACIN1 SCAF11 SRRM2 AFF4	1.64e-06	200	80	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CACNB2 MTUS1 SYNE1 PLXNA4 IRS1 SYT10	1.64e-06	200	80	6	8988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MTUS1 SYNE1 SVIL PLXNA4 IRS1 SYT10	1.64e-06	200	80	6	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MTUS1 SYNE1 SVIL PLXNA4 IRS1 SYT10	1.64e-06	200	80	6	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCell	5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNB2 DSCAM KIF19 RIMS2 NEUROG3	1.10e-05	162	80	5	478cf560ef33c5c324142c76417447d4a571a2c9
ToppCell	10x5'-Liver-Lymphocytic_Invariant-Inducer-like-ILC3\|Liver / Manually curated celltypes from each tissue	NEO1 SVIL PLXNA4 CTNND2 FAM124B	1.13e-05	163	80	5	7f61483eeb1fde21843c6391468e13cb0cc2a89f
ToppCell	droplet-Thymus-nan-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB2 CELSR3 PLXNA4 CTNND2 GAB2	1.43e-05	171	80	5	25493a4a7b636920e2cfd984542cc500709c9dcf
ToppCell	droplet-Thymus-nan-3m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB2 CELSR3 PLXNA4 CTNND2 GAB2	1.43e-05	171	80	5	508b41e3ad2638f9dd546d251b13ff60fc8c3207
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BNC2 HEG1 SYNE1 MKI67 ARHGEF3	1.47e-05	172	80	5	86f52f486d67217fc1b8443ab362c975df2974a4
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BNC2 HEG1 SYNE1 MKI67 ARHGEF3	1.47e-05	172	80	5	fb2df8fea6df5947165f13978f1d1006d15b60fd
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BNC2 HEG1 SYNE1 MKI67 ARHGEF3	1.47e-05	172	80	5	e38ebb216e4ddcd008148fcbaf709b4f3c83706a
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SVIL IRS1 SORBS1 SLC45A1 SYT10	1.51e-05	173	80	5	f8e3dded726bb3a6c24bfedf8c6732bb46262308
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SVIL IRS1 SORBS1 SLC45A1 SYT10	1.69e-05	177	80	5	e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BNC2 CACNB2 PLXNA4 IRS1 SORBS1	1.69e-05	177	80	5	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNB2 SHROOM3 DSCAM IRS1 SYT10	1.78e-05	179	80	5	e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 CACNB2 PLXNA4 IRS1 RIMS1	1.78e-05	179	80	5	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNB2 SHROOM3 DSCAM IRS1 SYT10	1.88e-05	181	80	5	30729f0364f719c044712a51453e22dc2c1a232b
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SVIL PLXNA4 SORBS1 RIMS2 SMTNL2	1.98e-05	183	80	5	a1d4f25e13f5b9e92a9ca0a804a7bed5df8fb2fe
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 CACNB2 PLXNA4 IRS1 RIMS1	1.98e-05	183	80	5	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	LPS-IL1RA\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	USP31 CNKSR3 FNDC3A LARP1B LUZP1	2.03e-05	184	80	5	c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCell	Ciliated_cells-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	KIF19 SPATA18 MUC16 STMND1 RIMS1	2.03e-05	184	80	5	07c5a9633ccdcd18771e3230d6198a55c400afa6
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D175\|Adult / Lineage, Cell type, age group and donor	SHROOM3 DSCAM MID1 CTNND2 RASAL2	2.09e-05	185	80	5	32b4e68e551d435a732f253f6ad83408c759a642
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 CACNB2 PLXNA4 IRS1 RIMS1	2.09e-05	185	80	5	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNB2 SHROOM3 MTUS1 IRS1 SYT10	2.14e-05	186	80	5	a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	CACNB2 SVIL CNKSR3 SORBS1 CTNND2	2.25e-05	188	80	5	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	USP31 HEG1 CNKSR3 ARHGEF3 CTNND2	2.25e-05	188	80	5	789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNB2 PLXNA4 IRS1 SORBS1 TAFA5	2.25e-05	188	80	5	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	BNC2 CACNB2 PLXNA4 IRS1 TAFA5	2.31e-05	189	80	5	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTUS1 IRS1 ARHGEF3 RASAL2 TECPR1	2.31e-05	189	80	5	09dd2b3d89416192e84abe302a6237b8f3fdcb6e
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	SHROOM3 MID1 SORBS1 RIMS1 RASAL2	2.31e-05	189	80	5	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	CACNB2 SVIL CNKSR3 FNDC3A SORBS1	2.31e-05	189	80	5	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 CACNB2 MTUS1 PLXNA4 SYT10	2.31e-05	189	80	5	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BNC2 PLXNA4 ASTN2 RIMS2 SMTNL2	2.37e-05	190	80	5	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	CACNB2 SVIL CNKSR3 FNDC3A SORBS1	2.37e-05	190	80	5	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	BNC2 CACNB2 PLXNA4 IRS1 SORBS1	2.37e-05	190	80	5	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	USP31 HEG1 ARHGEF3 CTNND2 RASAL2	2.37e-05	190	80	5	474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPIRE2 KIF19 SPATA18 STMND1 SYT10	2.43e-05	191	80	5	649fcb62ad15de2f83e61591e43923a717664ae7
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPIRE2 KIF19 SPATA18 STMND1 SYT10	2.43e-05	191	80	5	9621e22e14ea069f22713947c9faa2d882abe5fe
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	CACNB2 SVIL CNKSR3 SORBS1 CTNND2	2.43e-05	191	80	5	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 CACNB2 MTUS1 PLXNA4 SYT10	2.43e-05	191	80	5	b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 MTUS1 MID1 FNDC3A NAALADL2	2.49e-05	192	80	5	f7e7491426bbd6ed29a465b58bf67acb93dbb90a
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SVIL IRS1 SORBS1 CTNND2 SYT10	2.55e-05	193	80	5	146e8c148478ab61b1c1dbaf1ee98a8cd4a0ff8a
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	USP31 HEG1 SORBS1 ARHGEF3 LUZP1	2.55e-05	193	80	5	a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM3 MTUS1 SYNE1 STMND1 FHDC1	2.55e-05	193	80	5	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HEG1 ARHGEF3 CTNND2 FAM124B RASAL2	2.62e-05	194	80	5	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	RA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	CACNB2 SVIL CNKSR3 ASTN2 SORBS1	2.62e-05	194	80	5	89812fb164065041357bb37a3c2d87028ec3de4e
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 MTUS1 SYNE1 FHDC1 TAFA5	2.62e-05	194	80	5	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DSCAM KIF19 CTNND2 RIMS2 NEUROG3	2.62e-05	194	80	5	b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CELSR3 KCNH1 KIF19 MUC16 MTPAP	2.62e-05	194	80	5	2dcc3b99dbedaf8a6916891c85091ddb79d7ee31
ToppCell	Control-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	MTUS1 CNKSR3 SORBS1 FHDC1 GAB2	2.62e-05	194	80	5	a01de094f7bfd099bcbb2f94224690a2efb887b4
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CACNB2 SVIL PLXNA4 IRS1 SORBS1	2.68e-05	195	80	5	4dba732c8d8ecf0ed9ece1814dc4060402199ed9
ToppCell	Control-Multiplet\|Control / Disease state, Lineage and Cell class	SHROOM3 MTUS1 SYNE1 CNKSR3 FHDC1	2.68e-05	195	80	5	618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NEO1 SVIL SORBS1 RIMS1 SYT10	2.68e-05	195	80	5	44f67437ea65d530133a0240b17f9860d9cc0e99
ToppCell	Control-Multiplet-Multiplet\|Control / Disease state, Lineage and Cell class	SHROOM3 MTUS1 SYNE1 CNKSR3 FHDC1	2.68e-05	195	80	5	06ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCell	Control-Epithelial\|Control / Disease state, Lineage and Cell class	SHROOM3 MTUS1 SYNE1 CNKSR3 FHDC1	2.68e-05	195	80	5	1798c3b89b1b5ff4f5777d2b9f52dc81cdad28fa
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCNH1 SYNE1 RIMS1 RIMS2 RASAL2	2.75e-05	196	80	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 KANSL1 SCAPER NAALADL2 GAB2	2.89e-05	198	80	5	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BNC2 SYNE1 SORBS1 FHDC1 TAFA5	3.03e-05	200	80	5	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BNC2 SYNE1 SORBS1 FHDC1 TAFA5	3.03e-05	200	80	5	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 MID1 MUC16 ARHGEF3 NAALADL2	3.03e-05	200	80	5	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	KCNH1 SYNE1 RIMS1 RIMS2 RASAL2	3.03e-05	200	80	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MTUS1 SYNE1 SVIL IRS1 SYT10	3.03e-05	200	80	5	c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_ALM_Olfr111_Spon1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NFE2L3 SVIL CNKSR3 FHDC1	8.11e-05	127	80	4	cd69ba386796715e87674f8324d2acaad1d4d094
ToppCell	TCGA-Peripheral_Nervous_System-Primary_Tumor-Paraganglioma-Paraganglioma-3\|TCGA-Peripheral_Nervous_System / Sample_Type by Project: Shred V9	SYNE1 SVIL FNDC3A SCAF11	1.03e-04	135	80	4	ac20133d4a36f48338b45bffb13e842cb66f83ad
ToppCell	primary_visual_cortex\|World / Per Region, Lineage, Cell class, Cell type, Cell subtype	KMT2A SORBS1 RIMS2 SYT10	1.22e-04	141	80	4	605d7b28e99c943f64b4095855a6f9f70e92cb09
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-7\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	CNKSR3 KMT2A SORBS1 FAM124B	1.35e-04	145	80	4	88090a226ddfa6df59976f025bf0fd84ca0f72ef
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Sc17a7.Calb1-Fos_(Layer_2/3,_IEG+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MUC16 STMND1 NEUROG3	1.40e-04	56	80	3	a6a0345ddb9db1441fc048bc4d7b05f625de2ccd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 MID1 ARHGEF3 NAALADL2	1.66e-04	153	80	4	9b6675ace8a83c8d446b722301d0ec4e6840f3fc
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SPIRE2 MID1 FHDC1 NAALADL2	1.79e-04	156	80	4	e6798d2b9c2c1fc6525c24f596f25aa85a375651
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NFE2L3 KIF21B SORBS1 RASAL2	1.79e-04	156	80	4	c11ca6b1b5029c15aab91273cece70a487287839
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNB2 INSYN1 DSCAM SYT10	1.84e-04	157	80	4	c17c5c01fcb65c453690c265ec4f300ecdfefd34
ToppCell	Ciliated_cells-B-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	KIF19 SPATA18 MUC16 STMND1	2.07e-04	162	80	4	5319603f7ba3f48126dcf2ba9ae604be11bf2577
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SARS2 CELSR3 KIF19 TRIOBP	2.07e-04	162	80	4	ca30d9bf61f4133566fdc91c7996e130ea554d01
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN2 RIMS1 RIMS2 NAALADL2	2.07e-04	162	80	4	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BNC2 CACNB2 PLXNA4 IRS1	2.17e-04	164	80	4	e3983f655cdba308fb192182829f17bef99ce0ba
ToppCell	15-Distal-Epithelial-Multiciliated_precursor\|Distal / Age, Tissue, Lineage and Cell class	KIF19 SPATA18 STMND1 SYT10	2.32e-04	167	80	4	442ea71a581ed5a547a214132b9f1b0243fd0895
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BNC2 INSYN1 FAM124B SMTNL2	2.32e-04	167	80	4	e1b1a952fce27ab9cf16919b290625ff4a75261e
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	BNC2 HEG1 PLXNA4 NAALADL2	2.38e-04	168	80	4	45ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP31 KANSL1 KIF19 CWC22	2.43e-04	169	80	4	4e1322cc5e1733e9fb19e08f739a30206f43cea8
ToppCell	Control-Epithelial_cells-ECM-high_epithelial\|Control / group, cell type (main and fine annotations)	SHROOM3 HEG1 CNKSR3 RASAL2	2.49e-04	170	80	4	e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM3 MID1 SPATA18 STMND1	2.54e-04	171	80	4	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	NS-critical-LOC-Lymphoid-NK\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 SYNE1 PLXNA4 ARHGEF3	2.54e-04	171	80	4	adda76991d9b150bb8ccf3989b7cbbf41843cf0b
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BNC2 INSYN1 FAM124B SMTNL2	2.78e-04	175	80	4	59249c9e83952d7277010e7be3c779e26399eb5d
Drug	Tenoxicam [59804-37-4]; Down 200; 11.8uM; MCF7; HT_HG-U133A	DSCAM RBL2 FNDC3A CTNND2 TMEM80 RASAL2 LRRC41 DNMT3B	4.20e-07	197	79	8	2860_DN
Drug	Adamantamine fumarate [80789-67-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	RNF6 PWWP3A FNDC3A CTNND2 SRRM2 PIP5K1C LRRC41	5.05e-06	194	79	7	3280_DN
Drug	(-)-depudecin; Down 200; 1uM; MCF7; HT_HG-U133A_EA	USP24 KMT2A FNDC3A SRRM2 AFF4 LUZP1 LRRC41	5.40e-06	196	79	7	982_DN
Disease	Neurodevelopmental Disorders	CDKL5 DSCAM KCNH1 KMT2A RIMS1	5.57e-06	93	80	5	C1535926
Disease	attention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia	KIF21B CACNB2 SYNE1 KMT2A CWC22	8.34e-06	101	80	5	EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Disease	vesicle-fusing ATPase measurement	KANSL1 ARHGEF3	2.17e-05	3	80	2	EFO_0802214
Disease	alcohol consumption measurement	KANSL1 CNKSR3 EIF4G1 SCAPER PLXNA4 ASTN2 SCAF11 TAFA5 CTNND2 RIMS2 SYT10 AFF4 DNMT3B	2.79e-05	1242	80	13	EFO_0007878
Disease	ovarian neoplasm	BNC2 KANSL1 RBL2 MKI67 MUC16	3.28e-05	134	80	5	C0919267
Disease	Malignant neoplasm of ovary	BNC2 KANSL1 RBL2 MKI67 MUC16	3.64e-05	137	80	5	C1140680
Disease	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related measurement	ARHGEF3 PIP5K1C	4.34e-05	4	80	2	EFO_0803114
Disease	brain measurement, neuroimaging measurement	KIF21B CACNB2 NEO1 KANSL1 CNKSR3 TRIOBP LUZP1 DNMT3B	1.24e-04	550	80	8	EFO_0004346, EFO_0004464
Disease	nicotine dependence symptom count	CACNB2 CNKSR3 PLXNA4 PWWP3A RIMS1 FANCM	1.27e-04	285	80	6	EFO_0009262
Disease	Malignant neoplasm of breast	MAGEA1 GUCY2F KCNH1 SYNE1 RPS6KB2 SPATA18 MKI67 ASTN2 SORBS1 RASAL2 DNMT3B	1.49e-04	1074	80	11	C0006142
Disease	age-related hearing impairment	BNC2 SPIRE2 HEG1 CNKSR3 PLXNA4 TRIOBP	2.54e-04	324	80	6	EFO_0005782
Disease	urate measurement, bone density	RNF6 DSCAM SYNE1 SGTA PLXNA4 MARCHF7 CTNND2 NAALADL2	2.76e-04	619	80	8	EFO_0003923, EFO_0004531
Disease	idiopathic osteonecrosis of the femoral head	CNKSR3 SPATA18 ASTN2	3.85e-04	52	80	3	EFO_1001930
Disease	nucleus accumbens volume change measurement	DSCAM MUC16	3.93e-04	11	80	2	EFO_0021493
Disease	skin melanoma (is_marker_for)	AFF4 DNMT3B	5.55e-04	13	80	2	DOID:8923 (is_marker_for)
Disease	Colorectal Carcinoma	CDKL5 CACNB2 SYNE1 EIF4G1 MKI67 ACIN1 CTNND2 RASAL2	6.34e-04	702	80	8	C0009402
Disease	autism spectrum disorder (implicated_via_orthology)	DSCAM RIMS1 CTNND2 RIMS2	7.90e-04	152	80	4	DOID:0060041 (implicated_via_orthology)
Disease	cortical thickness	BNC2 SHROOM3 SPIRE2 NEO1 KANSL1 CNKSR3 TRIOBP KMT2A ASTN2 LUZP1	8.41e-04	1113	80	10	EFO_0004840
Disease	coronary thrombosis, GM11992	DSCAM SCAPER	8.50e-04	16	80	2	EFO_0001124, EFO_1000883
Disease	cortical surface area measurement	BNC2 SHROOM3 SPIRE2 NEO1 KANSL1 CNKSR3 TRIOBP MARCHF7 ASTN2 FAM124B LUZP1	9.89e-04	1345	80	11	EFO_0010736
Disease	caudal middle frontal gyrus volume measurement	ASTN2 TAFA5	1.08e-03	18	80	2	EFO_0010290
Disease	intellectual disability (implicated_via_orthology)	KANSL1 RBL2 IRS1	1.13e-03	75	80	3	DOID:1059 (implicated_via_orthology)
Disease	diet measurement, HOMA-B	CNKSR3 PLXNA4	1.20e-03	19	80	2	EFO_0004469, EFO_0008111
Disease	pulse pressure measurement	BNC2 CACNB2 SHROOM3 KANSL1 DSCAM TRIOBP CTNND2 CWC22 SYT10 LUZP1 DNMT3B	1.30e-03	1392	80	11	EFO_0005763
Disease	response to heparin, antibody measurement	STMND1 NAALADL2	1.34e-03	20	80	2	EFO_0004556, EFO_0006816
Disease	hair colour measurement	BNC2 SHROOM3 SPIRE2 NEO1 KCNH1 SLC45A1 GAB2	1.41e-03	615	80	7	EFO_0007822
Disease	fumarate measurement	CNKSR3 SMTNL2	1.47e-03	21	80	2	EFO_0010480
Disease	creatinine measurement	KIF21B CDKL5 SHROOM3 SPIRE2 CELSR3 DSCAM SVIL ASTN2 GAB2	1.48e-03	995	80	9	EFO_0004518
Disease	hemoglobin change measurement	CNKSR3 KMT2A	1.62e-03	22	80	2	EFO_0600027
Disease	uterine fibroid	SYNE1 SPATA18 FNDC3A NAALADL2	2.13e-03	199	80	4	EFO_0000731
Disease	reticulocyte measurement	BNC2 SPIRE2 KANSL1 EIF4G1 IRS1 FHDC1 ARHGEF3 SLC45A1 GAB2	2.18e-03	1053	80	9	EFO_0010700
Disease	triacylglycerol 48:0 measurement	STMND1 CTNND2	2.26e-03	26	80	2	EFO_0010403
Disease	response to perphenazine	ASTN2 C4orf54	2.26e-03	26	80	2	GO_0097334
Disease	Acute monocytic leukemia	KMT2A FANCM	2.26e-03	26	80	2	C0023465
Disease	neuroimaging measurement	KIF21B CACNB2 SHROOM3 SPIRE2 NEO1 KANSL1 CNKSR3 RLIM LUZP1	2.41e-03	1069	80	9	EFO_0004346
Disease	chronic myeloid leukemia (is_marker_for)	GAB2 DNMT3B	2.44e-03	27	80	2	DOID:8552 (is_marker_for)
Disease	lobe attachment	KIF21B BNC2 CNKSR3 SPATA18	2.45e-03	207	80	4	EFO_0007667
Disease	Liver carcinoma	MAGEA1 CELSR3 MTUS1 MKI67 KMT2A IRS1	2.57e-03	507	80	6	C2239176
Disease	glucose metabolism disease (implicated_via_orthology)	RPS6KB2 IRS1	2.62e-03	28	80	2	DOID:4194 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSSVQARRLSQPESA	ACIN1	701	Q9UKV3
PNRSRNRSSSVDSFR	CCDC61	401	Q9Y6R9
TLQRSISFRSESRPD	ARHGEF3	66	Q9NR81
TRSESPAVRTRNNNS	DNMT3B	96	Q9UBC3
PAVRTRNNNSVSSRE	DNMT3B	101	Q9UBC3
DIRTFIESNNRTRSP	BNC2	281	Q6ZN30
FVASSSTIERDRQRP	CTNND2	1036	Q9UQB3
GPQARESFRSSRLQT	ASTN2	261	O75129
RQKSPAQSDSTTQRR	AFF4	546	Q9UHB7
DQRTDRSAPIRSASQ	CACNB2	501	Q08289
PEQTRRVTRNSSTQT	INSYN1	256	Q2T9L4
STTRRRLFVENDSPS	RBL2	676	Q08999
RVPSFARNTVASSSR	FHDC1	1031	Q9C0D6
SNAATSPERVRNATS	MUC16	776	Q8WXI7
TRQRQPSEGSSSREE	MAGEA1	71	P43355
VQVTRETERSFPRAS	NEUROG3	11	Q9Y4Z2
NSRQQTVLSRTPRSD	MTUS1	546	Q9ULD2
QRASRRSDSASSEPV	PRKCD	296	Q05655
RNTDQRSSENRRSEP	SPATA18	186	Q8TC71
RRFPINRSELSSSDE	FANCM	1456	Q8IYD8
RRNPETSVTQSSSAQ	CWC22	96	Q9HCG8
SEQRVPALRFNSSSV	PLXNA4	746	Q9HCM2
RGSTFPRQSRATETS	KIF21B	1201	O75037
TFRRDPTARTSQSQE	NFE2L3	326	Q9Y4A8
SRSRQQSSSSRESPV	RASAL2	916	Q9UJF2
TSQQPVRRRRGESSF	KANSL1	846	Q7Z3B3
RRSSQSPQELFEISR	KCNH1	961	O95259
FRRNRISSPEDISDS	ANKS4B	276	Q8N8V4
PSAVESRRNSRVTGN	HEG1	376	Q9ULI3
REQEPARRVSRSSFS	MKI67	116	P46013
QTSERSRVRSSNQLP	MTPAP	156	Q9NVV4
DTAAQTNSRLARPTR	IRS1	846	P35568
RLQERSRSQTPLSTA	RIMS1	211	Q86UR5
SEQSERPRGRISSFT	RIMS1	1366	Q86UR5
RTQEPTAANQTSSRS	KIF19	206	Q2TAC6
RTTTRSRSTERPDTN	RIMS2	1101	Q9UQ26
SVSAKRTSEPRSQRN	FAM124B	271	Q9H5Z6
PASTNRDTVESTRTR	FNDC3A	1151	Q9Y2H6
SFQITSEVQSGRSPR	GUCY2F	531	P51841
FPSSEIQRLREQNTS	CCDC57	516	Q2TAC2
PTESTDNRRVVQRSS	EIF4G1	1131	Q04637
LSNRQVSSPSFTNRR	LUZP1	416	Q86V48
NSERVVSSQRPFQES	MARCHF7	256	Q9H992
PFQESSDNEGRRTTR	MARCHF7	266	Q9H992
SQSPENESNDRRSRR	KMT2A	516	Q03164
RSSNSREQLDQVPSR	CELSR3	3196	Q9NYQ7
NERSSSRINIPERAS	FAM104B	46	Q5XKR9
TFQTQRLLDRSPSRS	CDKL5	296	O76039
QRRNSNPSAESVSAR	C4orf54	1341	D6RIA3
QSQSRSPKRDTTRES	SCAF11	861	Q99590
PSTDRINVTSNARRS	SCAPER	186	Q9BY12
GPETSRRRNVTFSQQ	SLC45A1	501	Q9Y2W3
VRSESQERPGSRNSS	LARP1B	86	Q659C4
ETRQSNSARLFVSDP	DSCAM	206	O60469
SENSRSVAATIPRRN	GAB2	376	Q9UQC2
RRRPCVQQSLSSSFT	PWWP3A	151	Q2TAK8
SNDSPRRSFTTEKRN	SARS2	26	Q9NP81
DRDSSQPRRTIARQT	TAFA5	51	Q7Z5A7
SPRDQQSSSSERGSR	SRRM2	2706	Q9UQ35
RSQIRSRTPSASNDD	SGTA	296	O43765
TSERFRTQPITSAER	SVIL	651	O95425
RTNRASAVARTSAPE	TMEM80	21	Q96HE8
TAEEKVSPRTRRQSN	SYNE1	3616	Q8NF91
SQFDTRFTRQTPVDS	RPS6KB2	356	Q9UBS0
AAPATRVTRRSTQES	LRRC41	316	Q15345
SETSEQPRYRRRTQS	PIP5K1C	541	O60331
RANSTESVRNTPSTD	NEO1	1296	Q92859
QQRSTSPVARRTRSQ	RNF6	186	Q9Y252
SPVARRTRSQTSVNF	RNF6	191	Q9Y252
SQRESRPVQQTTRRS	RNF6	326	Q9Y252
LRSQSTFQLSSEPER	SHROOM3	886	Q8TF72
SSPNRTTQRENSRTS	TRIOBP	391	Q9H2D6
RASRTSSPNRATRDN	TRIOBP	511	Q9H2D6
RTTQQDSPRTSCARR	TRIOBP	641	Q9H2D6
SESPNSFLDQESRRR	CNK3/IPCEF1	381	G9CGD6
SESPNSFLDQESRRR	CNKSR3	381	Q6P9H4
SQLRSSNRRFSIPES	RIPK3	306	Q9Y572
SVDVLNTTPRRSRQT	SPIRE2	686	Q8WWL2
SESTSARPSRSERNS	RLIM	181	Q9NVW2
ARPSRSERNSTEALT	RLIM	186	Q9NVW2
RDSIASRTRSRSQTP	RLIM	336	Q9NVW2
SRTRSRSQTPNNTVT	RLIM	341	Q9NVW2
VRANATRAPRSSSQE	TECPR1	1136	Q7Z6L1
RVTPDRSQTSQDLFS	SORBS1	1221	Q9BX66
SPSETRRERAFDANT	MID1	96	O15344
VRSQTLPRTSEAQAR	SMTNL2	301	Q2TAL5
ARVQRQITEPTSSTR	SYT10	156	Q6XYQ8
SRQSSSPEFRVQSFS	TOPORS	731	Q9NS56
SPEFRVQSFSERTNA	TOPORS	736	Q9NS56
EALSSRPFRNVSRQT	USP24	1266	Q9UPU5
SPSERNRRVNSDLVT	STMND1	76	H3BQB6
PFVRSVQRQSLSSRS	USP31	836	Q70CQ4
PSVDESFRQSRSNLT	NAALADL2	361	Q58DX5