Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alpha-L-fucosidase activity	FUCA1 FUCA2	1.83e-05	2	86	2	GO:0004560
GeneOntologyMolecularFunction	fucosidase activity	FUCA1 FUCA2	1.83e-05	2	86	2	GO:0015928
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	PTPN1 SMPDL3B INPP5D AZGP1 LARS1 MTMR3 LIPN GNAS DBR1 PLD3 CNP PPM1B PLCE1	3.97e-05	807	86	13	GO:0016788
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	PTPN1 SMPDL3B INPP5D MTMR3 GNAS PLD3 CNP PPM1B PLCE1	4.25e-05	386	86	9	GO:0042578
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR2 ITPR3	5.48e-05	3	86	2	GO:0005220
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	SMPDL3B GNAS PLD3 CNP PLCE1	6.22e-05	97	86	5	GO:0008081
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PI4K2B PIK3C2B PIK3CG	1.87e-04	26	86	3	GO:0052742
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 3-kinase activity	PIK3C2B PIK3CG	3.80e-04	7	86	2	GO:0035005
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	MAN1A2 SMPDL3B SI FUCA1 FUCA2	3.96e-04	144	86	5	GO:0016798
GeneOntologyMolecularFunction	lipid kinase activity	PI4K2B PIK3C2B PIK3CG	7.31e-04	41	86	3	GO:0001727
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-kinase activity	PIK3C2B PIK3CG	9.83e-04	11	86	2	GO:0016303
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	MAN1A2 SI FUCA1 FUCA2	1.03e-03	103	86	4	GO:0004553
GeneOntologyBiologicalProcess	fucose metabolic process	FUCA1 FUCA2 FUT6	3.77e-05	16	86	3	GO:0006004
GeneOntologyBiologicalProcess	phospholipid metabolic process	PI4K2B SMPDL3B PIK3C2B PIK3CG INPP5D MTMR3 OSBPL8 PTDSS2 PLCE1	5.29e-05	410	86	9	GO:0006644
GeneOntologyBiologicalProcess	glycerophospholipid metabolic process	PI4K2B PIK3C2B PIK3CG INPP5D MTMR3 OSBPL8 PTDSS2 PLCE1	5.71e-05	320	86	8	GO:0006650
GeneOntologyBiologicalProcess	cellular response to cAMP	PIK3CG ASS1 ITPR2 ITPR3	7.06e-05	53	86	4	GO:0071320
GeneOntologyBiologicalProcess	phosphatidylinositol metabolic process	PI4K2B PIK3C2B PIK3CG INPP5D MTMR3 PLCE1	7.82e-05	170	86	6	GO:0046488
GeneOntologyBiologicalProcess	glycoside metabolic process	FUCA1 FUCA2 AKR1B1	1.02e-04	22	86	3	GO:0016137
GeneOntologyBiologicalProcess	glycerolipid biosynthetic process	PI4K2B PIK3C2B PIK3CG INPP5D MTMR3 PTDSS2 PLCE1	1.30e-04	268	86	7	GO:0045017
GeneOntologyBiologicalProcess	phosphatidylinositol-mediated signaling	PIK3C2B PIK3CG PLCE1	1.33e-04	24	86	3	GO:0048015
GeneOntologyBiologicalProcess	phosphatidylinositol biosynthetic process	PI4K2B PIK3C2B PIK3CG INPP5D MTMR3	2.29e-04	132	86	5	GO:0006661
Domain	FUC_metazoa-typ	FUCA1 FUCA2	2.10e-05	2	86	2	IPR016286
Domain	Alpha_L_fucos	FUCA1 FUCA2	2.10e-05	2	86	2	SM00812
Domain	Glyco_hydro_29	FUCA1 FUCA2	2.10e-05	2	86	2	IPR000933
Domain	Fucosidase_C	FUCA1 FUCA2	2.10e-05	2	86	2	PF16757
Domain	Glyco_hydro_29_CS	FUCA1 FUCA2	2.10e-05	2	86	2	IPR018526
Domain	Alpha_L_fucos	FUCA1 FUCA2	2.10e-05	2	86	2	PF01120
Domain	ALPHA_L_FUCOSIDASE	FUCA1 FUCA2	2.10e-05	2	86	2	PS00385
Domain	Fucosidase_C	FUCA1 FUCA2	2.10e-05	2	86	2	IPR031919
Domain	InsP3_rcpt-bd	ITPR2 ITPR3	6.27e-05	3	86	2	IPR000493
Domain	PI3/4_kinase_cat_dom	PI4K2B PIK3C2B PIK3CG	7.32e-05	18	86	3	IPR000403
Domain	PI3_PI4_kinase	PI4K2B PIK3C2B PIK3CG	7.32e-05	18	86	3	PF00454
Domain	PI3_4_KINASE_3	PI4K2B PIK3C2B PIK3CG	7.32e-05	18	86	3	PS50290
Domain	PI3_4_KINASE_1	PI4K2B PIK3C2B PIK3CG	7.32e-05	18	86	3	PS00915
Domain	PI3_4_KINASE_2	PI4K2B PIK3C2B PIK3CG	7.32e-05	18	86	3	PS00916
Domain	RIH_assoc	ITPR2 ITPR3	3.11e-04	6	86	2	PF08454
Domain	RIH_assoc-dom	ITPR2 ITPR3	3.11e-04	6	86	2	IPR013662
Domain	RIH_dom	ITPR2 ITPR3	3.11e-04	6	86	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR2 ITPR3	3.11e-04	6	86	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR2 ITPR3	3.11e-04	6	86	2	IPR015925
Domain	-	ITPR2 ITPR3	3.11e-04	6	86	2	1.25.10.30
Domain	RYDR_ITPR	ITPR2 ITPR3	3.11e-04	6	86	2	PF01365
Domain	Ins145_P3_rec	ITPR2 ITPR3	3.11e-04	6	86	2	PF08709
Domain	aa-tRNA-synth_Ia	MARS2 LARS1	4.34e-04	7	86	2	IPR002300
Domain	PI3K_Ras-bd_dom	PIK3C2B PIK3CG	4.34e-04	7	86	2	IPR000341
Domain	PI3K_rbd	PIK3C2B PIK3CG	4.34e-04	7	86	2	PF00794
Domain	PI3K_RBD	PIK3C2B PIK3CG	4.34e-04	7	86	2	PS51546
Domain	tRNA-synt_1	MARS2 LARS1	4.34e-04	7	86	2	PF00133
Domain	PI3K_rbd	PIK3C2B PIK3CG	4.34e-04	7	86	2	SM00144
Domain	PI3K_C2_dom	PIK3C2B PIK3CG	5.76e-04	8	86	2	IPR002420
Domain	PI3K_C2	PIK3C2B PIK3CG	5.76e-04	8	86	2	PF00792
Domain	PI3K_C2	PIK3C2B PIK3CG	5.76e-04	8	86	2	PS51547
Domain	PI3K_C2	PIK3C2B PIK3CG	5.76e-04	8	86	2	SM00142
Domain	PI3Ka	PIK3C2B PIK3CG	7.39e-04	9	86	2	PF00613
Domain	-	PIK3C2B PIK3CG	7.39e-04	9	86	2	1.25.40.70
Domain	PI3Ka	PIK3C2B PIK3CG	7.39e-04	9	86	2	SM00145
Domain	MIR	ITPR2 ITPR3	9.21e-04	10	86	2	PS50919
Domain	MIR	ITPR2 ITPR3	9.21e-04	10	86	2	PF02815
Domain	MIR	ITPR2 ITPR3	9.21e-04	10	86	2	SM00472
Domain	MIR_motif	ITPR2 ITPR3	9.21e-04	10	86	2	IPR016093
Domain	PIK_HELICAL	PIK3C2B PIK3CG	9.21e-04	10	86	2	PS51545
Domain	PI_Kinase	PIK3C2B PIK3CG	9.21e-04	10	86	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C2B PIK3CG	9.21e-04	10	86	2	IPR001263
Domain	Rossmann-like_a/b/a_fold	MARS2 ASS1 LARS1	1.02e-03	43	86	3	IPR014729
Domain	-	MARS2 ASS1 LARS1	1.02e-03	43	86	3	3.40.50.620
Domain	-	MARS2 LARS1	1.12e-03	11	86	2	1.10.730.10
Domain	DUF4599	SPATA31D4 SPATA31D3	1.34e-03	12	86	2	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D3	1.34e-03	12	86	2	IPR027970
Domain	Ubiquitin-rel_dom	PIK3C2B MYO7B PIK3CG PLCE1 VCPIP1	1.61e-03	184	86	5	IPR029071
Domain	-	FUCA1 FUCA2	1.84e-03	14	86	2	2.60.40.1180
Domain	Glycoside_hydrolase_SF	SI FUCA1 FUCA2	1.87e-03	53	86	3	IPR017853
Domain	Glyco_hydro_b	FUCA1 FUCA2	2.12e-03	15	86	2	IPR013780
Domain	PI3/4_kinase_CS	PIK3C2B PIK3CG	2.12e-03	15	86	2	IPR018936
Domain	tRNAsynth_Ia_anticodon-bd	MARS2 LARS1	2.12e-03	15	86	2	IPR009080
Domain	-	PIK3C2B PIK3CG	2.41e-03	16	86	2	1.10.1070.11
Domain	PI3Kc	PIK3C2B PIK3CG	2.41e-03	16	86	2	SM00146
Domain	aa-tRNA-synth_I_CS	MARS2 LARS1	3.06e-03	18	86	2	IPR001412
Domain	AA_TRNA_LIGASE_I	MARS2 LARS1	3.41e-03	19	86	2	PS00178
Pathway	REACTOME_PHOSPHOLIPID_METABOLISM	PI4K2B PIK3C2B PIK3CG CSNK2A2 INPP5D MTMR3 OSBPL8 PTDSS2 PLD3	6.41e-07	211	67	9	M649
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	PIK3C2B PIK3CG INPP5D PLCE1 ITPR2 ITPR3	1.54e-06	76	67	6	M9052
Pathway	WP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY	PI4K2B PIK3C2B PIK3CG INPP5D PLCE1	2.46e-06	46	67	5	M48317
Pathway	WP_PHOSPHOINOSITIDES_METABOLISM	PIK3C2B PIK3CG INPP5D MTMR3 PLCE1	3.38e-06	49	67	5	M40046
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	PI4K2B PIK3C2B PIK3CG INPP5D MTMR3	3.74e-06	50	67	5	MM14641
Pathway	REACTOME_PHOSPHOLIPID_METABOLISM	PI4K2B PIK3C2B PIK3CG CSNK2A2 INPP5D MTMR3 OSBPL8 PTDSS2	3.91e-06	196	67	8	MM14591
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	PI4K2B PIK3C2B PIK3CG INPP5D MTMR3	5.01e-06	53	67	5	M662
Pathway	REACTOME_PI_METABOLISM	PI4K2B PIK3C2B PIK3CG INPP5D MTMR3	3.16e-05	77	67	5	MM14590
Pathway	BIOCARTA_AMAN_PATHWAY	MAN1A2 ST8SIA4 FUT6	4.48e-05	15	67	3	M22009
Pathway	REACTOME_PI_METABOLISM	PI4K2B PIK3C2B PIK3CG INPP5D MTMR3	4.81e-05	84	67	5	M676
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR2 ITPR3	2.20e-04	5	67	2	M49000
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY	ITPR2 ITPR3	3.30e-04	6	67	2	M47960
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	GNAS ITPR2 ITPR3	4.61e-04	32	67	3	MM14983
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	PI4K2B PTPN1 FBXO6 CSNK2A2 AFG3L2 LARS1 OSBPL8 RANBP6 EXOC1 GNAS PLD3 RRM1 CNP ITPR2 ITPR3	2.67e-06	1440	87	15	30833792
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PTPN1 MYBBP1A TMLHE AFG3L2 ASS1 MTMR3 OSBPL8 RANBP6 DHX35 GNAS CNP MTRF1L VCPIP1 ITPR2 ITPR3	4.25e-06	1496	87	15	32877691
Pubmed	Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.	CNP ITPR2 ITPR3	5.39e-06	14	87	3	34630045
Pubmed	Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.	ITPR2 ITPR3	6.19e-06	2	87	2	9065779
Pubmed	Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.	ITPR2 ITPR3	6.19e-06	2	87	2	17496801
Pubmed	Cell surface human alpha-L-fucosidase.	FUCA1 FUCA2	6.19e-06	2	87	2	11389735
Pubmed	Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.	ITPR2 ITPR3	6.19e-06	2	87	2	24901844
Pubmed	Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.	ITPR2 ITPR3	6.19e-06	2	87	2	33854148
Pubmed	Roles of mouse sperm-associated alpha-L-fucosidases in fertilization.	FUCA1 FUCA2	6.19e-06	2	87	2	23426913
Pubmed	KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP.	KIF1B MMP14	6.19e-06	2	87	2	26576027
Pubmed	Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.	ITPR2 ITPR3	6.19e-06	2	87	2	19528657
Pubmed	Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.	ITPR2 ITPR3	6.19e-06	2	87	2	8063813
Pubmed	Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	6.19e-06	2	87	2	8081734
Pubmed	Histamine H₄ receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation.	PIK3CG HRH4	6.19e-06	2	87	2	21469095
Pubmed	Role for alpha-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells.	FUCA1 FUCA2	6.19e-06	2	87	2	19666478
Pubmed	IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.	ITPR2 ITPR3	6.19e-06	2	87	2	16195467
Pubmed	Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.	ITPR2 ITPR3	6.19e-06	2	87	2	15632133
Pubmed	Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.	ITPR2 ITPR3	6.19e-06	2	87	2	15713744
Pubmed	Modulation of expression in BEAS-2B airway epithelial cells of α-L-fucosidase A1 and A2 by Th1 and Th2 cytokines, and overexpression of α-L-fucosidase 2.	FUCA1 FUCA2	6.19e-06	2	87	2	24469468
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	SMPDL3B AZGP1 TMEM132A ASS1 SI FUCA1 FUCA2 GNAS PLD3 ABHD14B AKR1B1 CNP	1.44e-05	1070	87	12	23533145
Pubmed	Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.	ITPR2 ITPR3	1.85e-05	3	87	2	21435446
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR2 ITPR3	1.85e-05	3	87	2	10874040
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR2 ITPR3	1.85e-05	3	87	2	9808793
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR2 ITPR3	1.85e-05	3	87	2	20395455
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR2 ITPR3	1.85e-05	3	87	2	17437169
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR2 ITPR3	1.85e-05	3	87	2	18194433
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR2 ITPR3	1.85e-05	3	87	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR2 ITPR3	1.85e-05	3	87	2	36350267
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR2 ITPR3	1.85e-05	3	87	2	27777977
Pubmed	The versatility and universality of calcium signalling.	ITPR2 ITPR3	1.85e-05	3	87	2	11413485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	1.85e-05	3	87	2	26009177
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR2 ITPR3	1.85e-05	3	87	2	17581770
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR2 ITPR3	1.85e-05	3	87	2	18241669
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR2 ITPR3	1.85e-05	3	87	2	1693919
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR2 ITPR3	1.85e-05	3	87	2	19068129
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR2 ITPR3	1.85e-05	3	87	2	23955339
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR2 ITPR3	1.85e-05	3	87	2	31979185
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR2 ITPR3	1.85e-05	3	87	2	24904548
Pubmed	Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis.	PIK3C2B PIK3CG	1.85e-05	3	87	2	23320105
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	1.85e-05	3	87	2	17327232
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR2 ITPR3	1.85e-05	3	87	2	16014380
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR2 ITPR3	1.85e-05	3	87	2	17890015
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR2 ITPR3	1.85e-05	3	87	2	23983250
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR2 ITPR3	1.85e-05	3	87	2	9858485
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR2 ITPR3	1.85e-05	3	87	2	20427533
Pubmed	Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.	KIF1B MMP14	1.85e-05	3	87	2	23354307
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	POGLUT3 FBXO6 AFG3L2 ASS1 FUCA2 PLD3 RRM1 VWDE PPM1B	2.34e-05	613	87	9	22268729
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	PTPN1 MTMR3 GNAS PPM1B ITPR2	2.69e-05	139	87	5	25476789
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	SPATA31D4 SPATA31D3 MYBBP1A EXOC1 MAGEE1 DNAH7	2.72e-05	233	87	6	37704626
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	PLCE1 ITPR2 ITPR3	2.95e-05	24	87	3	10843712
Pubmed	Searching QTL by gene expression: analysis of diabesity.	APOM INPP5D ASS1 PLCE1	3.12e-05	71	87	4	15760467
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	PTPN1 CSNK2A2 AFG3L2 MTMR3 OSBPL8 RANBP6 GNAS MMP14 CNP VCPIP1 ITPR3	3.16e-05	974	87	11	28675297
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR2 ITPR3	3.70e-05	4	87	2	25215520
Pubmed	Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1.	PIK3CG INPP5D	3.70e-05	4	87	2	17173042
Pubmed	Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.	ITPR2 ITPR3	3.70e-05	4	87	2	17925404
Pubmed	Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.	ITPR2 ITPR3	3.70e-05	4	87	2	21424589
Pubmed	IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis.	ITPR2 ITPR3	3.70e-05	4	87	2	26193638
Pubmed	Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.	ITPR2 ITPR3	3.70e-05	4	87	2	28615414
Pubmed	Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.	ITPR2 ITPR3	3.70e-05	4	87	2	10828023
Pubmed	Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.	CSNK2A2 ITPR3	3.70e-05	4	87	2	14685260
Pubmed	Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells.	PIK3CG AKR1B1	3.70e-05	4	87	2	20354121
Pubmed	Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function.	SYN1 GNAS	3.70e-05	4	87	2	27759003
Pubmed	IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.	ITPR2 ITPR3	3.70e-05	4	87	2	28419336
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	3.70e-05	4	87	2	11163362
Pubmed	IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.	ITPR2 ITPR3	3.70e-05	4	87	2	35494252
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PIK3C2B PIK3CG CNP	4.23e-05	27	87	3	11156964
Pubmed	Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.	CNP ITPR2 ITPR3	5.27e-05	29	87	3	32123907
Pubmed	TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer.	PTPN1 GNAS CNP	5.85e-05	30	87	3	34285210
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	POGLUT3 FBXO6 FUCA2 PLD3 MMP14	5.93e-05	164	87	5	32409323
Pubmed	Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro.	PTPN1 CSNK2A2	6.16e-05	5	87	2	9600099
Pubmed	InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.	ITPR2 ITPR3	6.16e-05	5	87	2	21568942
Pubmed	Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation.	PTPN1 CSNK2A2	6.16e-05	5	87	2	8491187
Pubmed	Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors.	ITPR2 ITPR3	6.16e-05	5	87	2	21436055
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	PTPN1 MYBBP1A KIF1B AFG3L2 LARS1 OSBPL8 RRM1 CNP VCPIP1	7.12e-05	708	87	9	39231216
Pubmed	Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).	MAN1A2 AZGP1 GNAS PLD3 FUT6 ABHD14B CNP	8.68e-05	417	87	7	19199708
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	ITPR2 ITPR3	9.22e-05	6	87	2	23463619
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR2 ITPR3	9.22e-05	6	87	2	21762810
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	ITPR2 ITPR3	9.22e-05	6	87	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	ITPR2 ITPR3	9.22e-05	6	87	2	25966694
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	ITPR2 ITPR3	9.22e-05	6	87	2	16844763
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	MARS2 POGLUT3 CSNK2A2 AFG3L2 ASS1 LARS1 OSBPL8 GNAS PLD3 RRM1 BABAM2 CNP	9.23e-05	1297	87	12	33545068
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	KLHL11 PTPN1 MYBBP1A CSNK2A2 LARS1 GNAS CNP VCPIP1	9.42e-05	571	87	8	37167062
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KANSL3 KMT2B PIK3C2B SGSM2 TMEM132A MTMR3 MMP14 BABAM2 METTL27 ITPR2 ITPR3	9.78e-05	1105	87	11	35748872
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	MARS2 TMLHE AFG3L2 ASS1 PTDSS2 GNAS MTRF1L	1.18e-04	438	87	7	32628020
Pubmed	CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks.	PIK3C2B PIK3CG	1.29e-04	7	87	2	18755982
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	ITPR2 ITPR3	1.29e-04	7	87	2	11860456
Pubmed	Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.	ITPR2 ITPR3	1.29e-04	7	87	2	22495310
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	GPR83 KIF1B OSBPL8 PLCE1	1.34e-04	103	87	4	10819331
Pubmed	Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.	PIK3CG GNAS PLCE1	1.62e-04	42	87	3	21909110
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	ITPR2 ITPR3	1.72e-04	8	87	2	19033399
Pubmed	Co-clustering of Fcgamma and B cell receptors induces dephosphorylation of the Grb2-associated binder 1 docking protein.	PIK3CG INPP5D	1.72e-04	8	87	2	11453982
Pubmed	USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer.	FUCA1 PPM1B	1.72e-04	8	87	2	36864055
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	PTPN1 POGLUT3 OSBPL8 PTDSS2 PLD3 ITPR2 ITPR3	1.77e-04	468	87	7	31056421
Pubmed	Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7.	CSNK2A2 TAF1A	2.20e-04	9	87	2	12783858
Pubmed	Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.	ITPR2 ITPR3	2.20e-04	9	87	2	25737585
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	MYBBP1A CSNK2A2 KIF1B AFG3L2 LARS1 OSBPL8 SYN1 EXOC1 PLD3 AKR1B1 CNP ITPR2	2.30e-04	1431	87	12	37142655
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	PTPN1 AFG3L2 PTDSS2 PLD3 MMP14 CNP PPM1B	2.61e-04	499	87	7	22810586
Pubmed	The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.	PIK3C2B PIK3CG	2.75e-04	10	87	2	8636073
Pubmed	Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.	PIK3C2B PIK3CG	2.75e-04	10	87	2	8798481
Pubmed	Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity.	PIK3C2B PIK3CG	2.75e-04	10	87	2	9247029
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR2 ITPR3	2.82e-05	3	56	2	297
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3C2B PIK3CG	2.61e-04	8	56	2	831
GeneFamily	Aminoacyl tRNA synthetases, Class I	MARS2 LARS1	1.56e-03	19	56	2	131
Coexpression	ZHENG_BOUND_BY_FOXP3	DENND6A MAN1A2 PIK3CG LARS1 CLEC2D OSBPL8 IFT80 ST8SIA4 ITPR2	3.44e-05	498	85	9	M1741
Coexpression	ZHENG_BOUND_BY_FOXP3	DENND6A MAN1A2 PIK3CG LARS1 CLEC2D OSBPL8 IFT80 ST8SIA4 ITPR2	3.95e-05	507	85	9	MM1030
Coexpression	ZENG_GU_POST_ICB_METAGENE_41	KANSL3 POGLUT3 DENND6A BBS4 PTDSS2 IFT80	4.21e-05	195	85	6	MM17091
Coexpression	GSE360_HIGH_DOSE_B_MALAYI_VS_M_TUBERCULOSIS_MAC_UP	AFG3L2 ASS1 FUCA1 AKR1B1 BABAM2 DNAH7	4.72e-05	199	85	6	M5263
Coexpression	GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_UP	ASB3 UBR3 GNAS AKR1B1 METTL27 ITPR3	4.85e-05	200	85	6	M7742
Coexpression	GSE17721_CPG_VS_GARDIQUIMOD_1H_BMDC_UP	APOM GPR83 PUS10 KIF1B ST8SIA4 ITPR2	4.85e-05	200	85	6	M3878
Drug	GDP-fucose	GPR83 FUCA1 FUCA2 FUT6 AKR1B1	5.91e-06	68	86	5	CID000000451
Drug	FL4c	FUCA1 FUCA2	1.41e-05	2	86	2	CID000124915
Drug	adenophostin A	ITPR2 ITPR3	1.41e-05	2	86	2	ctd:C085029
Drug	MDL 25,637	SI FUCA1 FUCA2	1.45e-05	13	86	3	CID000128548
Drug	aminals	FUCA1 FUCA2 GNAS	1.84e-05	14	86	3	CID000075408
Drug	AC1OAGYH	SI FUCA1 FUCA2	2.29e-05	15	86	3	CID006857622
Disease	renal cell carcinoma	POGLUT3 MYO7B STN1 ITPR2	6.00e-06	42	83	4	EFO_0000681
Disease	event-related brain oscillation	KANSL3 GNAS	4.67e-05	4	83	2	EFO_0004358
Disease	cardiovascular measurement	TMEM232 STN1	1.16e-04	6	83	2	EFO_0004298
Disease	diabetic retinopathy (biomarker_via_orthology)	PIK3CG FUCA1 AKR1B1	2.80e-04	45	83	3	DOID:8947 (biomarker_via_orthology)
Disease	Carcinoma, Granular Cell	AZGP1 HRH4 MMP14 PLCE1	3.28e-04	116	83	4	C0205644
Disease	Adenocarcinoma, Tubular	AZGP1 HRH4 MMP14 PLCE1	3.28e-04	116	83	4	C0205645
Disease	Adenocarcinoma, Oxyphilic	AZGP1 HRH4 MMP14 PLCE1	3.28e-04	116	83	4	C0205642
Disease	Carcinoma, Cribriform	AZGP1 HRH4 MMP14 PLCE1	3.28e-04	116	83	4	C0205643
Disease	Adenocarcinoma, Basal Cell	AZGP1 HRH4 MMP14 PLCE1	3.28e-04	116	83	4	C0205641
Disease	Adenocarcinoma	AZGP1 HRH4 MMP14 PLCE1	3.28e-04	116	83	4	C0001418
Disease	Calcium channel blocker use measurement	SLC27A6 SORCS3 GNAS AKR1B1 PLCE1	3.44e-04	213	83	5	EFO_0009930
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR2 ITPR3	5.07e-04	12	83	2	DOID:1441 (implicated_via_orthology)
Disease	mosquito bite reaction itch intensity measurement, mosquito bite reaction size measurement	ASB3 DHX35 EXOC1 FUT6 AKR1B1	2.36e-03	328	83	5	EFO_0008377, EFO_0008378

Protein segments in the cluster

Peptide	Gene	Start	Entry
PFDWKILYNLGLVHL	BBS4	301	Q96RK4
GKEFPEVHLGQWYFI	APOM	36	O95445
AGWYLEHADPLLKVS	AFG3L2	581	Q9Y4W6
VLPELWKEHEAFYSS	ASB16	386	Q96NS5
DRLHWDLYIGTPLDF	CCNI2	241	Q6ZMN8
WLGPAYREFEVLKAH	ANGPTL8	141	Q6UXH0
PVADWKIFYFLRSLH	FBXO6	71	Q9NRD1
KFAELVYTGFWHSPE	ASS1	316	P00966
KLDYLDLYLIHWPTG	AKR1B1	101	P15121
ADHWYFDLLSKLPED	CCDC60	451	Q8IWA6
KHWVFDEASLEPGYP	MMP14	386	P50281
FYIHPFWKLRSEGDN	ITPR2	161	Q14571
LHWPELLFLEGSEAY	ITPR3	1621	Q14573
KLSLPEDFYHFWKFC	HPF1	46	Q9NWY4
SYLASEILWGHRFEP	KCNJ4	306	P48050
YLDKPEEWHTGLLDF	ABHD14B	191	Q96IU4
QLFLWEYGDLHLFGP	PLD3	56	Q8IV08
EKDEDHALSYWKPFL	PTPN1	396	P18031
SLHYFKLLPDWNHFD	LIPN	361	Q5VXI9
YEFFWGPRSHLETTK	MAGEE1	651	Q9HCI5
GSDPFYDRFHWFKLV	KIF1B	876	O60333
GKFWHIADLHLDPDY	SMPDL3B	21	Q92485
LDIFWFHLPEIYFDA	OR52A4P	86	A6NMU1
LEWFHPLYLLDKKNG	FUCA1	186	P04066
LESAFGWFDAHDPKY	KMT2B	1501	Q9UMN6
PADLFWKYLDLATFI	GPR83	231	Q9NYM4
WIHYINFLKETLDPG	PRPF39	166	Q86UA1
YGLLKHSREFLDFFW	MYBBP1A	26	Q9BQG0
HSREFLDFFWDIAKP	MYBBP1A	31	Q9BQG0
GIPDLAQKLHFYDRW	METTL27	21	Q8N6F8
THYFFWLLKDGLKDS	PIK3C2B	951	O00750
GIAVHWYLDFLAPAK	GBA	346	P04062
GLAFPFKHPDEWRAY	PI4K2B	346	Q8TCG2
LFELDPLTGEWHYKF	OSBPL8	731	Q9BZF1
YKWITHPLFSEELGV	PUS10	186	Q3MIT2
YSLFEWFHPLFLEDE	FUCA2	181	Q9BTY2
YKEWLPHLLVAGFDP	ASB3	391	Q9Y575
VKLPDDIYPIDFHWF	IFT80	51	Q9P2H3
DIYPIDFHWFPKSLG	IFT80	56	Q9P2H3
FYTLPFHLIRDWLSD	KLHL11	241	Q9NVR0
FKLHIPYAGETLKWD	BABAM2	56	Q9NXR7
AIESAWLLELAPHFY	DHX35	671	Q9H5Z1
LTWHLEICYKFPDEF	DNAH7	2131	Q8WXX0
WIGLYRHFLKSPNFD	DENND6A	501	Q8IWF6
DFPPEFYEHAKALWE	GNAS	141	P63092
LEKDFLPLYFGWFLT	CNP	181	P09543
KLRLIDWGLAEFYHP	CSNK2A2	171	P19784
FENSLHPDYITEKLW	FUT6	246	P51993
YLLFSGDDLLPLDHW	MAN1A2	601	O60476
ELDLVFLDHSYAKPW	KANSL3	31	Q9P2N6
SELLEHLKPTYWFSA	DBR1	211	Q9UK59
ENPEFDLHFEKIYKW	EXOC1	86	Q9NV70
PAKIEDLFSFAYHAW	MTMR3	121	Q13615
LYIPHTLFEWDFGKE	HRH4	71	Q9H3N8
LLVIDEPHTDWAKYF	SYN1	116	P17600
LWGLDPVFLAFAKLY	STN1	16	Q9H668
FFSPINWDDLYHKRL	SGK2	291	Q9HBY8
EPYARVLFHLKGQDW	TMEM132A	136	Q24JP5
LGYWPQKEHFIDAET	TMEM200A	81	Q86VY9
QKAFDHGTELIPWYV	PLCE1	836	Q9P212
LFHPKQEDWVLAYSL	SORCS3	301	Q9UPU3
RWHFETLEYFPSELG	MTRF1L	161	Q9UGC7
IVKFSEAEHWLDYFP	LARS1	171	Q9P2J5
PEIIWKLGSEILFYH	TAF1A	96	Q15573
DKLDGFVPAHFLGWY	PTDSS2	191	Q9BVG9
IRKDVWPFLLGHYKF	SGSM2	571	O43147
HLFWFGDLNYRVDLP	INPP5D	581	Q92835
FCDEIHLYGFWPFPK	ST8SIA4	291	Q92187
KYVQLFWGLPSLHSE	SPATA31D4	496	Q6ZUB0
IPHGLEDWSFFAVYD	PPM1B	46	O75688
LLHEFFDEKPTWDIF	SI	1611	P14410
HWPEGLKFLIDSIYS	RANBP6	136	O60518
FLLRYKGPSDHWIGL	CLEC2D	121	Q9UHP7
PLTAEDKELLWHFRY	PIK3CG	566	P48736
FYVNLGDWPLEHRKV	POGLUT3	236	Q7Z4H8
LGDPHFYQDSLWLRK	TMEM138	141	Q9NPI0
DHSLSPGWYRFLILD	VWDE	56	Q8N2E2
KYVQLFWGLPSLHSE	SPATA31D3	496	P0C874
AFAIYLEPWHLDIFE	RRM1	296	P23921
GISSPYHEELWKLNF	TMEM232	16	C9JQI7
EFISEKWLFHSPDYI	TTC41P	1276	Q6P2S7
DILKFHAIYWPAFLL	MARS2	311	Q96GW9
FKHFWDGKEYDNLPE	VCPIP1	576	Q96JH7
LAYDFYPGKIDVHWT	AZGP1	226	P25311
FLEELLFWTIKYEFP	UBR3	381	Q6ZT12
SILGGLWDFDYHPEF	ZNF713	141	Q8N859
KAFSDLPYFRTHEWA	ZNF625	76	Q96I27
LHFLQKLLFPYFWDD	SLC27A6	16	Q9Y2P4
LFFTWPDGHVTKYDL	TMLHE	116	Q9NVH6
DAFVKGIYGHLFLWI	MYO7B	396	Q6PIF6