Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription corepressor activity

CYS1 RB1 PAWR ZFPM1 RERE DRAP1 ZNF541

8.49e-06229647GO:0003714
GeneOntologyMolecularFunctiontranscription coregulator activity

CYS1 RB1 PAWR ZFPM1 RERE DRAP1 KAT6B MED12 ZNF541 ZXDB

1.11e-055626410GO:0003712
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

CYS1 RB1 BAZ2A PAWR ZFPM1 RERE DRAP1 KAT6B MED12 HCLS1 ZNF541 ZXDB

2.76e-0411606412GO:0030674
GeneOntologyMolecularFunctionmolecular adaptor activity

CYS1 SASH1 RB1 BAZ2A PAWR ZFPM1 RERE DRAP1 KAT6B MED12 HCLS1 ZNF541 ZXDB

3.12e-0413566413GO:0060090
GeneOntologyMolecularFunctionhistone H3K14 acetyltransferase activity

BRPF3 KAT6B

3.59e-049642GO:0036408
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

BRPF3 KAT6B

1.03e-0315642GO:0010484
GeneOntologyCellularComponentMOZ/MORF histone acetyltransferase complex

BRPF3 KAT6B

1.92e-047642GO:0070776
GeneOntologyCellularComponentH3 histone acetyltransferase complex

BRPF3 KAT6B

2.55e-048642GO:0070775
DomainZnF_C2HC

FAM90A14 ZCCHC2 FAM90A1 FAM90A18 FAM90A9 FAM90A10

2.18e-0855606SM00343
DomainZnf_CCHC

FAM90A14 ZCCHC2 FAM90A1 FAM90A18 FAM90A9 FAM90A10

2.18e-0855606IPR001878
DomainPHD

BRPF3 KMT2B BAZ2A KAT6B

9.86e-0575604PF00628
DomainZnf_PHD-finger

BRPF3 KMT2B BAZ2A KAT6B

1.21e-0479604IPR019787
DomainPHD

BRPF3 KMT2B BAZ2A KAT6B

1.92e-0489604SM00249
DomainZnf_PHD

BRPF3 KMT2B BAZ2A KAT6B

2.09e-0491604IPR001965
DomainZF_PHD_2

BRPF3 KMT2B BAZ2A KAT6B

2.46e-0495604PS50016
DomainZF_PHD_1

BRPF3 KMT2B BAZ2A KAT6B

2.56e-0496604PS01359
DomainELM2

RERE ZNF541

7.74e-0413602PF01448
DomainELM2

RERE ZNF541

7.74e-0413602PS51156
DomainELM2_dom

RERE ZNF541

7.74e-0413602IPR000949
DomainELM2

RERE ZNF541

7.74e-0413602SM01189
DomainZnf_FYVE_PHD

BRPF3 KMT2B BAZ2A KAT6B

1.28e-03147604IPR011011
DomainEPHD

BRPF3 KMT2B

2.25e-0322602PS51805
DomainBromodomain_CS

BRPF3 BAZ2A

3.14e-0326602IPR018359
DomainSANT_dom

RERE ZNF541

3.14e-0326602IPR017884
DomainAT_hook

KMT2B BAZ2A

3.38e-0327602SM00384
DomainAT_hook_DNA-bd_motif

KMT2B BAZ2A

3.38e-0327602IPR017956
DomainSANT

RERE ZNF541

3.64e-0328602PS51293
DomainMyb_DNA-binding

RERE ZNF541

5.64e-0335602PF00249
DomainBROMODOMAIN_1

BRPF3 BAZ2A

6.29e-0337602PS00633
DomainMYB_LIKE

RERE ZNF541

6.62e-0338602PS50090
DomainBromodomain

BRPF3 BAZ2A

6.62e-0338602PF00439
DomainBROMODOMAIN_2

BRPF3 BAZ2A

7.68e-0341602PS50014
DomainBROMO

BRPF3 BAZ2A

8.05e-0342602SM00297
DomainBromodomain

BRPF3 BAZ2A

8.05e-0342602IPR001487
Domain-

BRPF3 BAZ2A

8.05e-03426021.20.920.10
DomainSAM_2

SASH1 INPPL1

8.42e-0343602PF07647
DomainWW

FNBP4 ARHGAP27

1.00e-0247602PF00397
DomainWW

FNBP4 ARHGAP27

1.04e-0248602SM00456
Pubmed

Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.

FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A2P FAM90A1 FAM90A18 FAM90A9 FAM90A16 FAM90A10

1.30e-2125681017684299
Pubmed

Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.

FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A2P FAM90A9 FAM90A16 FAM90A10

6.68e-172368818602769
Pubmed

Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.

FAM90A14 FAM90A17 RB1 FAM90A19 FAM90A22 FAM90A26 FAM90A1 FAM90A9 FAM90A10

3.59e-1116468922967998
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

ADORA1 FAM193B KMT2B HSPBP1 RERE DRAP1 KAT6B HCLS1 WNK2

2.83e-0660868916713569
Pubmed

Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping.

RB1 RBBP5

3.77e-0626827558034
Pubmed

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.

KMT2B RBBP5 PSPC1 MED12

5.61e-065968428813667
Pubmed

Interaction of BCR-ABL with the retinoblastoma protein in Philadelphia chromosome-positive cell lines.

RB1 BCR

1.13e-0536829071815
Pubmed

Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice.

CYS1 RB1

1.13e-0536828191288
Pubmed

Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

INPPL1 BCR HCLS1

2.79e-053068312522270
Pubmed

Evolving Catalytic Properties of the MLL Family SET Domain.

KMT2B RBBP5

3.75e-05568226320581
Pubmed

Distinct mesenchymal cell states mediate prostate cancer progression.

RB1 NKX3-1

3.75e-05568238191471
Pubmed

Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis.

RB1 ZFPM1

3.75e-05568219513100
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FAM193B KMT2B SZT2 INPPL1 MEX3D ZFPM1 BCR MED12 WNK2 TBC1D17

5.50e-051105681035748872
Pubmed

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.

BRPF3 KAT6B

7.86e-05768218794358
Pubmed

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.

KMT2B RBBP5

7.86e-05768230604749
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

BRPF3 SASH1 SZT2 FNBP4 KAT6B BCR WNK2

7.87e-0552968714621295
Pubmed

Impact of WIN site inhibitor on the WDR5 interactome.

KMT2B RBBP5 RERE

8.34e-054368333472061
Pubmed

Examining the specificity of Src homology 3 domain--ligand interactions with alkaline phosphatase fusion proteins.

INPPL1 HCLS1

1.05e-0486829126384
Pubmed

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

KMT2B RBBP5

1.34e-04968222665483
Pubmed

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.

PSPC1 HEXIM1

1.68e-041068228712728
Pubmed

Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.

KMT2B RBBP5

1.68e-041068218838538
Pubmed

A novel pro-Arg motif recognized by WW domains.

KMT2B FNBP4

1.68e-041068210744724
Pubmed

Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association.

PRKCSH BCR

2.05e-041168212586822
Pubmed

Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.

BRPF3 RBBP5 PSPC1 BCR MED12

2.36e-0428368528533407
Pubmed

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

KMT2B RBBP5

2.45e-041268217707229
Pubmed

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

KMT2B RBBP5

2.45e-041268227563068
Pubmed

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.

KMT2B RBBP5

2.90e-041368221502505
Pubmed

Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.

KMT2B FNBP4

3.38e-04146828605874
Pubmed

Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.

SZT2 RBBP5 EIF2AK3

3.71e-047168336305789
Pubmed

SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.

KMT2B RBBP5

4.44e-041668223870121
Pubmed

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.

KMT2B RBBP5

4.44e-041668224368734
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

BRPF3 KMT2B SASH1 BAZ2A WNK2

4.70e-0432968517474147
Pubmed

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.

KMT2B RBBP5

5.03e-041768226180087
Pubmed

The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.

CYS1 PRKCSH

5.03e-041768216472605
Pubmed

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

KMT2B RBBP5

5.65e-041868217500065
Pubmed

Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.

KMT2B RBBP5

7.00e-042068219047629
Pubmed

Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.

FAM193B INPPL1 ZNF574

7.93e-049268320368287
Pubmed

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.

ADORA1 CLIP3 NOL3 SZT2 INPPL1 PAWR ZCCHC2 HEXIM1

8.36e-04102168826760575
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

KMT2B RBBP5

8.48e-042268226886794
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

NKX3-1 RERE PSPC1 MED12

9.24e-0422068435785414
Pubmed

Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.

NOL3 EIF2AK3

1.01e-032468227106802
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

KMT2B BAZ2A KAT6B

1.13e-031046839205841
Pubmed

Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter.

INPPL1 MYO16

1.28e-032768234709416
Pubmed

Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.

BAZ2A BCR

1.28e-032768219026994
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

BRPF3 PPP2R5A RB1 BAZ2A RERE KAT6B BCR ZNF574

1.47e-03111668831753913
Pubmed

The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.

SASH1 RBM12B

1.58e-033068230480076
Pubmed

DULIP: A Dual Luminescence-Based Co-Immunoprecipitation Assay for Interactome Mapping in Mammalian Cells.

RB1 HSPBP1 DRAP1

1.62e-0311868326264872
Pubmed

Identification and characterization of a novel human PP1 phosphatase complex.

KMT2B RBBP5

1.69e-033168220516061
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

RBBP5 BCR HEXIM1 TBC1D17 ZXDB ZNF574

1.71e-0365068638777146
Pubmed

A pancreatic cancer-specific expression profile.

FNBP4 PRKCSH

1.80e-03326828895530
Pubmed

Genetic variations in humans associated with differences in the course of hepatitis C.

IL10RA SULT2B1

1.80e-033268215063762
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

RBBP5 RERE MED12 HEXIM1

1.91e-0326868433640491
InteractionKAT8 interactions

KMT2B BAZ2A RBBP5 RERE KAT6B

7.87e-0695585int:KAT8
InteractionFAM90A26 interactions

FAM90A26 FAM90A1

8.14e-062582int:FAM90A26
Cytoband8p23.1

FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A2P FAM90A18 FAM90A9 FAM90A16 FAM90A10

1.77e-121546898p23.1
CytobandEnsembl 112 genes in cytogenetic band chr8p23

FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A2P FAM90A18 FAM90A9 FAM90A16 FAM90A10

7.55e-11234689chr8p23
CytobandEnsembl 112 genes in cytogenetic band chr19q13

CLIP3 KMT2B SULT2B1 HSPBP1 SLC7A10 TBC1D17 ZNF541 ZNF574

3.76e-041192688chr19q13
GeneFamilyPHD finger proteins

BRPF3 KMT2B BAZ2A KAT6B

3.34e-059037488
GeneFamilyZinc fingers C2HC-type|PHD finger proteins|Lysine acetyltransferases

ZFPM1 KAT6B

4.80e-041637266
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RB1 RBM12B BAZ2A HASPIN ZFPM1 HEXIM1

1.25e-07173606c31076c725f4cd912c56903592a2d9356ae59f54
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RB1 RBM12B BAZ2A HASPIN ZFPM1 HEXIM1

1.25e-07173606a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
Diseaseneuroimaging measurement

NEUROD2 KMT2B KCNA5 SZT2 RBBP5 PRKCSH RERE ARHGAP27 BCR EIF2AK3 MYO16 WNK2

3.25e-0710695312EFO_0004346
Diseasechildhood onset asthma

ADORA1 NEUROD2 RERE ARHGAP27 SLC7A10 HEXIM1

2.95e-05334536MONDO_0005405
Diseasebasophil measurement

ZFPM1 RERE SLC7A10

1.74e-0460533EFO_0803539
Diseasebasophil percentage of granulocytes

RBBP5 ZFPM1 SLC7A10

4.54e-0483533EFO_0007995
DiseaseAdrenocortical carcinoma

RB1 MED12

4.75e-0418532C0206686
DiseaseProstatic Neoplasms

SULT2B1 RB1 BAZ2A PAWR NKX3-1 MED12

8.06e-04616536C0033578
DiseaseMalignant neoplasm of prostate

SULT2B1 RB1 BAZ2A PAWR NKX3-1 MED12

8.06e-04616536C0376358
DiseaseMyeloid Leukemia, Chronic

CA9 BCR

1.25e-0329532C0023473
Diseasecleft lip

ADORA1 KCNA5 KAT6B MYO16

1.70e-03284534EFO_0003959
Diseasebasophil count

RBBP5 ZFPM1 RERE DRAP1 SLC7A10

1.73e-03483535EFO_0005090

Protein segments in the cluster

PeptideGeneStartEntry
EEAPGRDPSPVAPPD

CYS1

51

Q717R9
EPRGPEPDDETELRP

EIF2AK3

86

Q9NZJ5
PAPPIDEDLPEERPD

ADORA1

311

P30542
PQDAPEEEENGPCPP

SLC7A10

496

Q9NS82
PADGADPPPAEEPEA

BCR

101

P11274
DPPPAEEPEARPDGE

BCR

106

P11274
EPEPREDDVEAPPPP

AEBP1

46

Q8IUX7
PSQPPEEPEPDEAES

BAZ2A

1301

Q9UIF9
EPGRPAEPQPEPEEP

CCDC96

86

Q2M329
PEDDGDRDDSKLPPP

BRPF3

821

Q9ULD4
GTEPTPEPDPEPADE

C1orf232

131

A0A0U1RR37
APVGPRAPPPDEEDP

FAM90A10

26

A6NDY2
SPREEDPPGEEDLPG

CA9

71

Q16790
VGSPEPESEPEPEPE

SLC16A2

26

P36021
PPAPPGPSAPDEEDE

DRAP1

186

Q14919
PPPPEEDPEQDSGPE

RB1

26

P06400
PPDEDFRGPPDEDFR

RBM12B

806

Q8IXT5
PPPQRDEEEPDGVPE

PAWR

121

Q96IZ0
APEPEPEPEPTVGAE

RAB42

36

Q8N4Z0
PEAVPESDEEPPPGE

KAT6B

1496

Q8WYB5
LPPAAPPGDEDDSEP

MYO16

1396

Q9Y6X6
APVGPRAPPPDEEDP

FAM90A1

26

Q86YD7
EEEDSEEAPPPLSPP

PRKCSH

331

P14314
EPAGEEERPPPAAEG

KIAA2026

11

Q5HYC2
SDDEEPPDASLPPDP

FAM89B

151

Q8N5H3
GDFPPPAEVEPTPEA

HEXIM1

101

O94992
ARVGPRAPPPDEEDP

FAM90A22

26

A8MWA6
APVGPRAPPPDEEDP

FAM90A14

26

P0C7W9
QEPEPRPTEEEPGSP

ZFPM1

71

Q8IX07
EAAPAPRPPPEPDDA

MEX3D

41

Q86XN8
DDEDVEPQPPPQGPD

LRATD2

41

Q96KN1
PRPPSPFDDPADDPE

MED12

631

Q93074
SPPEPEVPGEEDPAA

IL10RA

426

Q13651
APEPEPPPADDSPAE

KMT2B

676

Q9UMN6
SPPPPEDLGPDFEDM

KMT2B

1966

Q9UMN6
APVGPRAPPPDEEDP

FAM90A17

26

P0DV74
APVGPRAPPPDEEDP

FAM90A16

26

P0DV73
APVGPRAPPPDEEDP

FAM90A19

26

P0DV76
PEVEDPEENPYGPPP

RBBP5

406

Q15291
EPEPEPEPESEPEPE

PPM1E

36

Q8WY54
PRPRRPPPEDEEEEG

KCNA5

86

P22460
PEAPAEPDHDGPRED

FAM193B

46

Q96PV7
DDPDDPDDPDFPGSP

HASPIN

61

Q8TF76
AEPPDGPAREQPEAP

DONSON

91

Q9NYP3
APVGPRAPPPDEEDP

FAM90A20P

26

A6NIJ5
PAPMAPPPRGEEEEE

CLIP3

6

Q96DZ5
APVGPRAPPPDEEDP

FAM90A5P

26

A8MXJ8
EDYGEPAPEEPPPAP

CTU2

6

Q2VPK5
APVGPRAPPPDEEDP

FAM90A24P

26

P0C7X0
GSEEPDPPPEPMSEE

HSPBP1

56

Q9NZL4
DDGLGPPLPPPEEER

SZT2

1661

Q5T011
EDPEEDGSPDPEPSP

SULT2B1

311

O00204
TPGRDPEPEPDTEPD

FNBP4

26

Q8N3X1
EAEPEPEPEPEPEPE

HCLS1

361

P14317
APVGPRAPPPDEEDP

FAM90A12P

26

A8MX19
APVGPRAPPPDEEDP

FAM90A9

26

A6NNJ1
APVGPRAPPPDEEDP

FAM90A13P

26

P0C7W8
APVGPRAPPPDEEDP

FAM90A26

26

D6RGX4
PPPEESAEQVDDPPE

ARHGAP27

211

Q6ZUM4
PVEGEREPDPPDDRD

INPPL1

116

O15357
QRDPEPEPEPEPEGG

NKX3-1

51

Q99801
AEPEPELEPEPDPEP

NOL3

181

O60936
EALDDAEEPESPPPP

RERE

1096

Q9P2R6
PELPRARDEEDPEPP

SYCE1L

221

A8MT33
APVGPRAPPPDEEDP

FAM90A15P

26

P0C7V4
PPSDNPDFDPEEDEP

PPP2R5A

136

Q15172
THPAEPPPEAEEPEA

ZCCHC2

11

Q9C0B9
PPPEAEEPEADARPG

ZCCHC2

16

Q9C0B9
ASDLPPPPDDEPEPG

TBC1D17

246

Q9HA65
PPPDDEPEPGFEVIS

TBC1D17

251

Q9HA65
PAEPAPAPAPEEEAE

ZXDB

236

P98169
APPAPAPPEDHPDEE

PSPC1

46

Q8WXF1
PEEGDATRDPGPEPE

PSD2

11

Q9BQI7
EPAPAETGEPEAPEP

ZNF574

436

Q6ZN55
APVGPRAPPPDEEDP

FAM90A2P

26

Q658T7
AAGPGPEPEPEPEPE

SASH1

6

O94885
AGQPGPPEPEEPEAD

WNK2

581

Q9Y3S1
RAAENGAPDPPEPEP

ZNF541

356

Q9H0D2
APVGPRAPPPDEEDP

FAM90A18

26

P0DV75
DDEPRSDKGDAPPPP

NEUROD2

26

Q15784