Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	secretory granule organization	NBEAL2 PTBP1 LYST CCDC136	2.98e-05	78	47	4	GO:0033363
HumanPheno	Rotary nystagmus	ACBD5 NPHP4 LYST ITPR1	1.21e-06	26	17	4	HP:0001583
Domain	CAPS	CADPS CADPS2	5.68e-06	2	45	2	IPR033227
Domain	DUF1041	CADPS CADPS2	5.65e-05	5	45	2	SM01145
Domain	PH_BEACH	NBEAL2 LYST	8.46e-05	6	45	2	PF14844
Domain	DUF1041	CADPS CADPS2	1.18e-04	7	45	2	PF06292
Domain	Munc13_1	CADPS CADPS2	1.18e-04	7	45	2	IPR014770
Domain	CAPS_dom	CADPS CADPS2	1.18e-04	7	45	2	IPR010439
Domain	MHD1	CADPS CADPS2	1.18e-04	7	45	2	PS51258
Domain	ARM-type_fold	DOCK1 PIK3CD NBEAL2 HUWE1 LYST ITPR1	1.53e-04	339	45	6	IPR016024
Domain	PH-BEACH_dom	NBEAL2 LYST	1.57e-04	8	45	2	IPR023362
Domain	PH_BEACH	NBEAL2 LYST	1.57e-04	8	45	2	PS51783
Domain	-	NBEAL2 LYST	1.57e-04	8	45	2	2.30.29.40
Domain	Beach	NBEAL2 LYST	2.02e-04	9	45	2	PF02138
Domain	-	NBEAL2 LYST	2.02e-04	9	45	2	1.10.1540.10
Domain	BEACH_dom	NBEAL2 LYST	2.02e-04	9	45	2	IPR000409
Domain	Beach	NBEAL2 LYST	2.02e-04	9	45	2	SM01026
Domain	BEACH	NBEAL2 LYST	2.02e-04	9	45	2	PS50197
Domain	Apc4_WD40_dom	EML6 WDR53	1.05e-03	20	45	2	IPR024977
Domain	ANAPC4_WD40	EML6 WDR53	1.05e-03	20	45	2	PF12894
Domain	MHC_I	MICB MICA	1.16e-03	21	45	2	PF00129
Domain	MHC_I_a_a1/a2	MICB MICA	1.16e-03	21	45	2	IPR001039
Domain	-	MICB MICA	1.51e-03	24	45	2	3.30.500.10
Domain	MHC_I-like_Ag-recog	MICB MICA	1.51e-03	24	45	2	IPR011161
Domain	WD40	NBEAL2 EML6 LYST WDR53	3.45e-03	259	45	4	PF00400
Domain	PH_dom-like	CADPS NBEAL2 DGKH CADPS2 LYST	3.48e-03	426	45	5	IPR011993
Domain	MHC_I/II-like_Ag-recog	MICB MICA	3.78e-03	38	45	2	IPR011162
Domain	WD40	NBEAL2 EML6 LYST WDR53	3.89e-03	268	45	4	SM00320
Domain	WD40_repeat	NBEAL2 EML6 LYST WDR53	4.10e-03	272	45	4	IPR001680
Domain	WD_REPEATS_1	NBEAL2 EML6 LYST WDR53	4.43e-03	278	45	4	PS00678
Domain	WD_REPEATS_2	NBEAL2 EML6 LYST WDR53	4.49e-03	279	45	4	PS50082
Domain	WD_REPEATS_REGION	NBEAL2 EML6 LYST WDR53	4.49e-03	279	45	4	PS50294
Domain	WD40_repeat_dom	NBEAL2 EML6 LYST WDR53	5.59e-03	297	45	4	IPR017986
Domain	WD40_repeat_CS	EML6 LYST WDR53	7.20e-03	164	45	3	IPR019775
Domain	C2_dom	CADPS PIK3CD CADPS2	7.20e-03	164	45	3	IPR000008
Domain	C1-set	MICB MICA	7.50e-03	54	45	2	PF07654
Domain	IGc1	MICB MICA	8.05e-03	56	45	2	SM00407
Domain	-	NBEAL2 EML6 LYST WDR53	8.32e-03	333	45	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	NBEAL2 EML6 LYST WDR53	8.49e-03	335	45	4	IPR015943
Domain	Ig_C1-set	MICB MICA	8.61e-03	58	45	2	IPR003597
Pubmed	CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells.	CADPS CADPS2	1.94e-06	2	49	2	18177725
Pubmed	PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis.	MICB MICA	1.94e-06	2	49	2	10691930
Pubmed	Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules.	MICB MICA	1.94e-06	2	49	2	9770516
Pubmed	[The polymorphism distributions of MICA and MICB microsatellite in Guangdong Han population].	MICB MICA	1.94e-06	2	49	2	15192843
Pubmed	[The study on the haplotype of MICA and MICB microsatellite locus in Guangzhou Han population].	MICB MICA	1.94e-06	2	49	2	15640005
Pubmed	CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.	CADPS CADPS2	1.94e-06	2	49	2	18022372
Pubmed	MICA/B expression is inhibited by unfolded protein response and associated with poor prognosis in human hepatocellular carcinoma.	MICB MICA	1.94e-06	2	49	2	25228093
Pubmed	MICA/B expression in macrophage foam cells infiltrating atherosclerotic plaques.	MICB MICA	1.94e-06	2	49	2	24997223
Pubmed	Association Between Major Histocompatibility Complex Class I Chain-Related Gene Polymorphisms and Susceptibility of Systemic Lupus Erythematosus.	MICB MICA	1.94e-06	2	49	2	29078849
Pubmed	Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells.	MICB MICA	1.94e-06	2	49	2	28677817
Pubmed	Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.	MICB MICA	1.94e-06	2	49	2	26902929
Pubmed	Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC).	MICB MICA	1.94e-06	2	49	2	36958849
Pubmed	High frequency of MIC null haplotype (HLA-B48-MICA-del-MICB*0107 N) in the Angaite Amerindian community in Paraguay.	MICB MICA	1.94e-06	2	49	2	12242594
Pubmed	MICA, MICB Polymorphisms and Linkage Disequilibrium with HLA-B in a Chinese Mongolian Population.	MICB MICA	1.94e-06	2	49	2	27028549
Pubmed	CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles.	CADPS CADPS2	1.94e-06	2	49	2	18495893
Pubmed	Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.	MICB MICA	1.94e-06	2	49	2	8901601
Pubmed	Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility.	MICB MICA	1.94e-06	2	49	2	30337538
Pubmed	Associations of high-resolution-typing-defined MICA and MICB polymorphisms, and the levels of soluble MICA and MICB with Oral Squamous Cell Carcinoma in Bulgarian patients.	MICB MICA	1.94e-06	2	49	2	33835601
Pubmed	Association study of MICA and MICB in Alzheimer's disease.	MICB MICA	1.94e-06	2	49	2	19691640
Pubmed	Impact of MICA-TM, MICB-C1_2_A and C1_4_1 microsatellite polymorphisms on the susceptibility to chronic periodontitis in Germany.	MICB MICA	1.94e-06	2	49	2	21388352
Pubmed	Diversity and characterization of polymorphic 5' promoter haplotypes of MICA and MICB genes.	MICB MICA	1.94e-06	2	49	2	24962621
Pubmed	MICB002 and MICB014 protect against rheumatoid arthritis, whereas MICA009 and MICAA6 are associated with rheumatoid arthritis in a Hainan Han Chinese population.	MICB MICA	1.94e-06	2	49	2	29665245
Pubmed	High resolution MIC genotyping: design and application to the investigation of inflammatory bowel disease susceptibility.	MICB MICA	1.94e-06	2	49	2	12392511
Pubmed	A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing.	MICB MICA	1.94e-06	2	49	2	18560379
Pubmed	CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons.	CADPS CADPS2	1.94e-06	2	49	2	28883501
Pubmed	Association of MICA and MICB alleles with symptomatic dengue infection.	MICB MICA	1.94e-06	2	49	2	21762746
Pubmed	In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer.	MICB MICA	1.94e-06	2	49	2	17565371
Pubmed	Conserved amino acids within the adenovirus 2 E3/19K protein differentially affect downregulation of MHC class I and MICA/B proteins.	MICB MICA	1.94e-06	2	49	2	19949079
Pubmed	The alteration of placental-derived soluble MHC class I chain-related protein A and B during pregnancy.	MICB MICA	1.94e-06	2	49	2	21426309
Pubmed	AluyMICB dimorphism within the class I region of the major histocompatibility complex is associated with asthma and airflow obstruction in the Busselton population.	MICB MICA	1.94e-06	2	49	2	16776673
Pubmed	Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB.	MICB MICA	1.94e-06	2	49	2	10359807
Pubmed	The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children.	MICB MICA	1.94e-06	2	49	2	28925058
Pubmed	Major Histocompatibility Complex Class I Chain-Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais.	MICB MICA	1.94e-06	2	49	2	32737971
Pubmed	Expression of major histocompatibility complex class I-related chain A/B (MICA/B) in pancreatic carcinoma.	MICB MICA	1.94e-06	2	49	2	24173243
Pubmed	MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue.	MICB MICA	1.94e-06	2	49	2	28334733
Pubmed	Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus.	MICB MICA	1.94e-06	2	49	2	34012432
Pubmed	Hepatitis B surface antigen inhibits MICA and MICB expression via induction of cellular miRNAs in hepatocellular carcinoma cells.	MICB MICA	1.94e-06	2	49	2	23917076
Pubmed	Wide distribution of the MICA-MICB null haplotype in East Asians.	MICB MICA	1.94e-06	2	49	2	11169252
Pubmed	Propionic acid secreted from propionibacteria induces NKG2D ligand expression on human-activated T lymphocytes and cancer cells.	MICB MICA	1.94e-06	2	49	2	19553547
Pubmed	Association of MICA-TM and MICB C1_2_A microsatellite polymorphisms with tumor progression in patients with colorectal cancer.	MICB MICA	1.94e-06	2	49	2	19353249
Pubmed	2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation.	MICB MICA	1.94e-06	2	49	2	22227571
Pubmed	Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: role of uric acid accumulation in gemcitabine-induced MICA/B expression.	MICB MICA	1.94e-06	2	49	2	21605422
Pubmed	MIC gene polymorphism and haplotype diversity in Zhuang nationality of Southern China.	MICB MICA	1.94e-06	2	49	2	25167773
Pubmed	A new polymorphic and multicopy MHC gene family related to nonmammalian class I.	MICB MICA	1.94e-06	2	49	2	7927538
Pubmed	Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid.	MICB MICA	1.94e-06	2	49	2	12569559
Pubmed	CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.	CADPS CADPS2	1.94e-06	2	49	2	25719439
Pubmed	Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.	MICB MICA	1.94e-06	2	49	2	14662896
Pubmed	Broad MICA/B expression in the small bowel mucosa: a link between cellular stress and celiac disease.	MICB MICA	1.94e-06	2	49	2	24058482
Pubmed	Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients.	MICB MICA	1.94e-06	2	49	2	26708143
Pubmed	Diversity and characterisation of polymorphic 3' untranslated region haplotypes of MICA and MICB genes.	MICB MICA	1.94e-06	2	49	2	30471210
Pubmed	Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia.	MICB MICA	1.94e-06	2	49	2	12714493
Pubmed	MICA and MICB microsatellite alleles in HLA extended haplotypes.	MICB MICA	1.94e-06	2	49	2	11881819
Pubmed	Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells.	MICB MICA	1.94e-06	2	49	2	12466900
Pubmed	Allelic and interlocus comparison of the PERB11 multigene family in the MHC.	MICB MICA	1.94e-06	2	49	2	8995188
Pubmed	Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition.	MICB MICA	1.94e-06	2	49	2	34482362
Pubmed	Association of MICA and MICB polymorphisms with the susceptibility of leukemia in Korean patients.	MICB MICA	1.94e-06	2	49	2	29895953
Pubmed	Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells.	MICB MICA	1.94e-06	2	49	2	9497295
Pubmed	HLA class I chain-related MICA and MICB genes polymorphism in healthy individuals from the Bulgarian population.	MICB MICA	1.94e-06	2	49	2	35525711
Pubmed	Two distinct secretory vesicle-priming steps in adrenal chromaffin cells.	CADPS CADPS2	1.94e-06	2	49	2	20855507
Pubmed	MICB polymorphisms and haplotypes with MICA and HLA alleles in Koreans.	MICB MICA	1.94e-06	2	49	2	21554252
Pubmed	Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity.	MICB MICA	1.94e-06	2	49	2	21042760
Pubmed	MICB microsatellite polymorphism is associated with ulcerative colitis in Chinese population.	MICB MICA	1.94e-06	2	49	2	16679067
Pubmed	[Expression of MICA/B protein in esophageal cancer and its clinical significance].	MICB MICA	1.94e-06	2	49	2	23291067
Pubmed	Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B.	MICB MICA	5.83e-06	3	49	2	18287244
Pubmed	Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family.	CADPS CADPS2	5.83e-06	3	49	2	12659812
Pubmed	An Alternative Exon of CAPS2 Influences Catecholamine Loading into LDCVs of Chromaffin Cells.	CADPS CADPS2	5.83e-06	3	49	2	30389842
Pubmed	Expression of MICA, MICB and NKG2D in human leukemic myelomonocytic and cervical cancer cells.	MICB MICA	5.83e-06	3	49	2	21477352
Pubmed	MMP9 Promoter Polymorphism (-1562 C/T) Does not Affect the Serum Levels of Soluble MICB and MICA in Breast Cancer.	MICB MICA	5.83e-06	3	49	2	27026046
Pubmed	Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.	MICB MICA	5.83e-06	3	49	2	26071561
Pubmed	Study on the haplotypes of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population.	MICB MICA	5.83e-06	3	49	2	15304009
Pubmed	A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.	CADPS CADPS2	5.83e-06	3	49	2	14530279
Pubmed	Midkine upregulates MICA/B expression in human gastric cancer cells and decreases natural killer cell cytotoxicity.	MICB MICA	5.83e-06	3	49	2	22415659
Pubmed	Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India.	MICB MICA	5.83e-06	3	49	2	16923796
Pubmed	Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection.	MICB MICA	5.83e-06	3	49	2	12538683
Pubmed	Mutual activation of CD4+ T cells and monocytes mediated by NKG2D-MIC interaction requires IFN-gamma production in systemic lupus erythematosus.	MICB MICA	5.83e-06	3	49	2	19200602
Pubmed	Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA.	MICB MICA	5.83e-06	3	49	2	24973455
Pubmed	[Expression of NKG2D ligands in multidrug-resistant nasopharyngeal carcinoma cell line CNE2/DDP and their effects on cytotoxicity of natural killer cells].	MICB MICA	5.83e-06	3	49	2	17584663
Pubmed	Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D.	MICB MICA	5.83e-06	3	49	2	17202358
Pubmed	Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.	MICB MICA	5.83e-06	3	49	2	12384702
Pubmed	Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells.	MICB MICA	5.83e-06	3	49	2	17625602
Pubmed	Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain.	CADPS CADPS2	5.83e-06	3	49	2	25437547
Pubmed	Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake.	CADPS CADPS2	5.83e-06	3	49	2	19008227
Pubmed	The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia.	MICB MICA	5.83e-06	3	49	2	20428196
Pubmed	Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis.	MICB MICA	5.83e-06	3	49	2	18791713
Pubmed	MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression.	MICB MICA	5.83e-06	3	49	2	16920948
Pubmed	Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17.	MICB MICA	5.83e-06	3	49	2	25363527
Pubmed	Vesicular stomatitis virus infection promotes immune evasion by preventing NKG2D-ligand surface expression.	MICB MICA	5.83e-06	3	49	2	21857986
Pubmed	Associations of major histocompatibility complex class I chain-related molecule polymorphisms with Behcet's disease in Caucasian patients.	MICB MICA	5.83e-06	3	49	2	16101830
Pubmed	Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease.	MICB MICA	5.83e-06	3	49	2	16568261
Pubmed	Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex.	MICB MICA	5.83e-06	3	49	2	16435885
Pubmed	MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility.	MICB MICA	5.83e-06	3	49	2	17003176
Pubmed	The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding.	MICB MICA	1.16e-05	4	49	2	32968163
Pubmed	Potential role of NKG2D/MHC class I-related chain A interaction in intrathymic maturation of single-positive CD8 T cells.	MICB MICA	1.16e-05	4	49	2	12902493
Pubmed	Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity.	MICB MICA	1.16e-05	4	49	2	25775242
Pubmed	Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility.	CADPS CADPS2	1.16e-05	4	49	2	19238500
Pubmed	Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17.	MICB MICA	1.16e-05	4	49	2	23526433
Pubmed	Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.	CADPS CADPS2	1.16e-05	4	49	2	29068313
Pubmed	The inhibitory effects of synthetic short peptides, mimicking MICA and targeting at NKG2D receptors, on function of NK cells.	MICB MICA	1.16e-05	4	49	2	15652646
Pubmed	Expression of the nonclassical HLA class I and MICA/B molecules in human hepatocellular carcinoma.	MICB MICA	1.16e-05	4	49	2	21744989
Pubmed	HER2/HER3 signaling regulates NK cell-mediated cytotoxicity via MHC class I chain-related molecule A and B expression in human breast cancer cell lines.	MICB MICA	1.16e-05	4	49	2	22301547
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL2 LYST	7.11e-05	9	26	2	1230
GeneFamily	WD repeat domain containing	NBEAL2 EML6 LYST WDR53	5.01e-04	262	26	4	362
GeneFamily	C1-set domain containing	MICB MICA	1.65e-03	42	26	2	591
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CADPS DGKH CADPS2	3.12e-03	206	26	3	682
Coexpression	SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP	CUL1 MICB CCR1 MICA ITPR1	4.53e-07	82	49	5	M9224
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1\|TCGA-Adrenal / Sample_Type by Project: Shred V9	AKAP6 GFOD1 CADPS GPR68 MAT2A	1.56e-06	179	49	5	431e1b29015ec817f778499106d24b19cfc825ae
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CROCC2 EML6 DLEC1 DNAAF1	2.48e-05	154	49	4	58072ce422d09f2de602580325eaac6c4ec6c136
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells-Ciliated\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CROCC2 EML6 DLEC1 DNAAF1	2.48e-05	154	49	4	9ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CROCC2 DGKH DLEC1 DNAAF1	3.57e-05	169	49	4	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RARRES2 GCC1 ZNF112 DNAAF1	4.46e-05	179	49	4	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACACB EML6 CADPS2 ITPR1	4.46e-05	179	49	4	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	facs-Marrow-T-cells-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EML6 ACBD5 ZNF112 HUWE1	4.66e-05	181	49	4	57f0cc749ae8b6a3d77e2af31f9a6e4739c57049
ToppCell	facs-Marrow-T-cells-3m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EML6 ACBD5 ZNF112 HUWE1	4.66e-05	181	49	4	d01b35cc2fc57991a35be6a06cb7351fbabd9a11
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	AKAP6 RAPGEF5 DGKH ITPR1	4.86e-05	183	49	4	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	(04)_Pre-ciliated-(3)_72hpi\|(04)_Pre-ciliated / shred by cell type and Timepoint	CROCC2 DLEC1 DNAAF1 NPHP4	5.40e-05	188	49	4	f911dc61b008b60aaa2a1e9354085f480a669e2c
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 ACACB EML6 CADPS2	5.51e-05	189	49	4	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	3'-Adult-Distal_Rectal-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GFOD1 RAPGEF5 ITPR1 FAM167B	5.51e-05	189	49	4	0c612ff5f882f2d8ec744a347780bbbe7cc471bd
ToppCell	3'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GFOD1 RAPGEF5 ITPR1 FAM167B	5.51e-05	189	49	4	bc8949bd4f425ed36e2c05e653c94cb1593c5bee
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RAPGEF5 EML6 CADPS2 ITPR1	5.51e-05	189	49	4	c3df0e3c50af8f1cfb4d790e668bd7f42b276992
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GFOD1 RAPGEF5 CADPS2 LYST	5.63e-05	190	49	4	1caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	RARRES2 GFOD1 RAPGEF5 ITPR1	5.98e-05	193	49	4	5896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AKAP6 CROCC2 DLEC1 DNAAF1	6.10e-05	194	49	4	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AKAP6 CROCC2 DLEC1 DNAAF1	6.47e-05	197	49	4	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	normal_Lung-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	RARRES2 GFOD1 RAPGEF5 ITPR1	6.60e-05	198	49	4	e0e47cf65774191981840b22905b2094b95abe0f
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FAM200A GSPT1 WDR53 ITPR1	6.86e-05	200	49	4	cc8368665bc6bb7c4f39632ccff07ceaa98a7b65
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid-Megakaryocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FAM200A GSPT1 WDR53 ITPR1	6.86e-05	200	49	4	0d76b006d8e8b32174e65e400acd0674354b962c
Drug	Mexiletine hydrochloride [5370-01-4]; Up 200; 18.6uM; MCF7; HT_HG-U133A	AKAP6 CEP250 CACNA1I PTBP1 SULT4A1 LYST	3.32e-06	195	48	6	3862_UP
Drug	Tolazoline hydrochloride [59-97-2]; Up 200; 20.4uM; MCF7; HT_HG-U133A	CEP250 ROM1 MSI1 LYST GSPT1 ITPR1	3.74e-06	199	48	6	1500_UP
Drug	Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	TRAFD1 RAPGEF5 PIK3CD LYST ITPR1	3.50e-05	177	48	5	5209_UP
Drug	Trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A	TRAFD1 PIK3CD DNAAF1 LYST ITPR1	3.70e-05	179	48	5	6951_UP
Drug	trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A	TRAFD1 PIK3CD DNAAF1 LYST ITPR1	4.00e-05	182	48	5	7043_UP
Drug	Trichlormethiazide [133-67-5]; Up 200; 10.6uM; HL60; HT_HG-U133A	AKAP6 RARRES2 ACACB CACNA1I HUWE1	5.42e-05	194	48	5	2998_UP
Drug	Quinethazone [73-49-4]; Up 200; 13.8uM; MCF7; HT_HG-U133A	RARRES2 GPR68 CCR1 CACNA1I SULT4A1	5.70e-05	196	48	5	3875_UP
Drug	Oxytetracycline dihydrate [6153-64-6]; Up 200; 8uM; MCF7; HT_HG-U133A	RARRES2 GPR68 CEP250 GSPT1 ITPR1	5.98e-05	198	48	5	3170_UP
Drug	Avermectin B1 [71751-41-2]; Down 200; 4.8uM; MCF7; HT_HG-U133A	DOCK1 TRAFD1 NBEAL2 ROM1 DNAAF1	5.98e-05	198	48	5	7218_DN
Drug	Nialamide [51-12-7]; Up 200; 13.4uM; PC3; HT_HG-U133A	ACACB RAPGEF5 MSI1 HUWE1 DNAAF1	5.98e-05	198	48	5	3790_UP
Drug	Mephenesin [59-47-2]; Up 200; 22uM; PC3; HT_HG-U133A	RAPGEF5 CCR1 CACNA1I DNAAF1 GSPT1	6.12e-05	199	48	5	3675_UP
Disease	serum hepcidin measurement	EML6 DGKH	4.06e-04	18	49	2	EFO_0004504
Disease	economic and social preference	AKAP6 CADPS EML6	5.69e-04	97	49	3	EFO_0004827
Disease	Bronchiectasis	PIK3CD DNAAF1	6.11e-04	22	49	2	C0006267
Disease	body weight	AKAP6 DOCK1 CADPS DGKH MICA HUWE1 CADPS2 ITPR1	1.03e-03	1261	49	8	EFO_0004338
Disease	MHC class I polypeptide-related sequence B measurement	MICB MICA	1.14e-03	30	49	2	EFO_0008234
Disease	verbal-numerical reasoning measurement	AKAP6 CACNA1I GCC1	1.36e-03	131	49	3	EFO_0008394
Disease	pulmonary function measurement, forced expiratory volume	MICB DGKH	1.73e-03	37	49	2	EFO_0003892, EFO_0004314
Disease	platelet measurement	NBEAL2 MICB EML6 MICA	1.85e-03	315	49	4	EFO_0005036
Disease	hepatocellular carcinoma	MICA DLEC1	2.13e-03	41	49	2	EFO_0000182
Disease	ejection fraction measurement	DGKH CADPS2	2.34e-03	43	49	2	EFO_0005527
Disease	hydroxy-leucine measurement	CADPS DGKH	2.56e-03	45	49	2	EFO_0005276
Disease	cervical carcinoma	ACACB MICB MICA	3.45e-03	182	49	3	EFO_0001061
Disease	atopic asthma	GLDC MICB MICA	4.43e-03	199	49	3	EFO_0010638

Protein segments in the cluster

Peptide	Gene	Start	Entry
VCIHQDINDDHVEDV	ACBD5	281	Q5T8D3
TLLQHIEENIINEDC	FAM200A	401	Q8TCP9
HCPIETQVLREAEEH	RARRES2	116	Q99969
HSLQEIRVCEIHEDN	MICA	111	Q29983
HILNVSIQCADHLED	ACACB	1421	O00763
AELVIEVLQQNEEHH	CADPS	886	Q9ULU8
VTTEEIDHAVHLACI	METAP1	161	P53582
EINERVVQHFVHCIE	ITPR1	1296	Q14643
VHLHQTVQVDDELEI	INTS11	136	Q5TA45
VEEQEENEQLCVHHV	HSP90AB4P	296	Q58FF6
HTIVISVQHDEEVCL	MAT2A	201	P31153
QEIIARIAQHLIHCD	FAM214A	371	Q32MH5
HSLQEIRVCEIHEDS	MICB	111	Q29980
TIHCLLEQELAHAVN	DGKH	1011	Q86XP1
HIENQDECVLNVISH	MRPL37	146	Q9BZE1
ELEESHDQHAVLVLQ	HUWE1	3866	Q7Z6Z7
DIVEKVCEIHFHEIN	MSI1	161	O43347
NAVLHIHTCIEEVEI	GSPT1	411	P15170
EEELLELHVQDHFQE	NPHP4	256	O75161
LSCEELEHQHQQEAD	GCC1	536	Q96CN9
LIEIVHSDLFTQHDC	DOCK1	841	Q14185
HECEQSRHLDLAVQV	CCR1	271	P32246
CHRIHSLEQELAQAE	CROCC2	1266	H7BZ55
CEQVLIEKHLEIFHT	CUL1	291	Q13616
HHEQPEELTNILEIC	CACNA1I	661	Q9P0X4
KEVECQQEHIHELQE	CEP250	1736	Q9BV73
LCIEVLQQNEEHHAE	CADPS2	846	Q86UW7
IHLRIHELQDCDANV	CEP95	21	Q96GE4
EIVHEPNHQEILRDC	LYST	2766	Q99698
HEVCLHQVESISDLH	LSMEM2	41	Q8N112
HLETVEDIQHLQECL	DNAAF1	206	Q8NEP3
LEHTDDILCLTVNQH	EML6	1411	Q6ZMW3
LHCQHLETVLELEVE	DLEC1	936	Q9Y238
ACHLHQELLDEAELE	FAM167B	116	Q9BTA0
EVIEDENQHRVCFEH	GPR68	161	Q15743
QLEEEVLFHHQDQCD	TRAFD1	376	O14545
DEVLLHQDVDLVCIN	GFOD1	56	Q9NXC2
DELHVLAEQLHQADL	NBEAL2	61	Q6ZNJ1
LEHLLNDLHLEEVQD	RAPGEF5	81	Q92565
CEDISDHVEQIHALL	AKAP6	111	Q13023
LQEELQCHEAELQHL	CCDC136	446	Q96JN2
AQLEALTEHCHQLVD	SULT4A1	221	Q9BR01
QGCHEVLLEHLQDLA	ROM1	251	Q03395
TLHQRNHISEEVLCI	ZNF546	821	Q86UE3
RHSECVHVTEEEQLQ	PIK3CD	496	O00329
SLDHFHVNEEEINCL	WDR53	86	Q7Z5U6
LHIHQNIEREDDIEN	ZNF112	301	Q9UJU3
LHLQCSEEQLEFLAH	STRCP1	1621	A6NGW2
VEEAVQALIDLHNHD	PTBP1	501	P26599
FEENISDVCDLIHQH	GLDC	706	P23378