Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	BROMODOMAIN_1	TRIM33 BRD4	2.98e-03	37	41	2	PS00633
Domain	Bromodomain	TRIM33 BRD4	3.14e-03	38	41	2	PF00439
Domain	MFS_dom	MFSD8 SLC33A1 SVOPL	3.15e-03	134	41	3	IPR020846
Domain	GDS_CDC24_CS	DNMBP PLEKHG4	3.31e-03	39	41	2	IPR001331
Domain	BROMODOMAIN_2	TRIM33 BRD4	3.65e-03	41	41	2	PS50014
Domain	BROMO	TRIM33 BRD4	3.83e-03	42	41	2	SM00297
Domain	Bromodomain	TRIM33 BRD4	3.83e-03	42	41	2	IPR001487
Domain	-	TRIM33 BRD4	3.83e-03	42	41	2	1.20.920.10
Domain	DH_1	DNMBP PLEKHG4	8.44e-03	63	41	2	PS00741
Domain	RhoGEF	DNMBP PLEKHG4	9.77e-03	68	41	2	SM00325
Domain	RhoGEF	DNMBP PLEKHG4	1.03e-02	70	41	2	PF00621
Domain	DH_2	DNMBP PLEKHG4	1.03e-02	70	41	2	PS50010
Domain	DH-domain	DNMBP PLEKHG4	1.06e-02	71	41	2	IPR000219
Domain	-	DNMBP PLEKHG4	1.06e-02	71	41	2	1.20.900.10
Pubmed	TRAIL overexpression co-regulated by Egr1 and HRE enhances radiosensitivity of hypoxic A549 cells depending on its apoptosis inducing role.	EGR1 TNFSF10	1.42e-06	2	42	2	27878298
Pubmed	Enhanced radiosensitivity of SW480 cells via TRAIL up-regulation mediated by Egr-1 promoter.	EGR1 TNFSF10	1.42e-06	2	42	2	19724854
Pubmed	Phorbol myristate acetate-induced Egr-1 expression is suppressed by phospholipase D isozymes in human glioma cells.	PLD1 EGR1	1.42e-06	2	42	2	18067864
Pubmed	C-Reactive protein downregulates TRAIL expression in human peripheral monocytes via an Egr-1-dependent pathway.	EGR1 TNFSF10	1.42e-06	2	42	2	23468057
Pubmed	Early-immediate gene Egr1 is associated with TGFβ1 regulation of epigenetic reader Bromodomain-containing protein 4 via the canonical Smad3 signaling in hepatic stellate cells in vitro and in vivo.	EGR1 BRD4	4.27e-06	3	42	2	36250963
Pubmed	Cockayne syndrome group B deficiency reduces H3K9me3 chromatin remodeler SETDB1 and exacerbates cellular aging.	SETDB1 ERCC6	4.27e-06	3	42	2	31276581
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	TRIM33 RBM22 ERCC6 AP2B1 BRD4	7.11e-06	222	42	5	37071664
Pubmed	Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.	BMP2K EGR1 SVOPL	1.24e-05	37	42	3	22432025
Pubmed	Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters.	SYT10 BRD4	1.42e-05	5	42	2	31294688
Pubmed	Profound regulation of Na/K pump activity by transient elevations of cytoplasmic calcium in murine cardiac myocytes.	ZDHHC5 PLD1	1.42e-05	5	42	2	27627745
Pubmed	Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an EPCR- independent mechanism involving Egr-1/Erk-1/2 activation.	EGR1 TNFSF10	1.42e-05	5	42	2	17932312
Pubmed	Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.	NOA1 POLR2B	2.13e-05	6	42	2	21909106
Pubmed	Association of Tat with promoters of PTEN and PP2A subunits is key to transcriptional activation of apoptotic pathways in HIV-infected CD4+ T cells.	EGR1 TNFSF10	2.13e-05	6	42	2	20862322
Pubmed	Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses.	EGR1 TNFSF10	2.13e-05	6	42	2	14560009
Pubmed	Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes.	EGR1 TNFSF10	7.78e-05	11	42	2	19050264
Pubmed	Zinc finger protein genes in the mouse genome.	EGR1 ZFP30	9.32e-05	12	42	2	1797234
Pubmed	A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility.	PLD1 TNFSF10	1.48e-04	15	42	2	14996723
Pubmed	The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation.	BRD4 POLR2B	2.15e-04	18	42	2	23087374
Pubmed	Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs.	FMOD ITGA5	2.15e-04	18	42	2	12571105
Pubmed	Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb.	AP2B1 BMP2K	2.15e-04	18	42	2	23211419
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	PRPSAP1 TRIM33 SETDB1 AP2B1 BMP2K POLR2B CRY1	2.24e-04	1038	42	7	26673895
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TRIM33 SETDB1 PLD1 ERCC6 AKAP17A BRD4 POLR2B	3.47e-04	1116	42	7	31753913
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TRIM33 RBM22 ERCC6 AKAP17A DNMBP BMP2K NOA1 POLR2B	3.69e-04	1497	42	8	31527615
Pubmed	Integral and associated lysosomal membrane proteins.	DEPDC5 MFSD8 PLD1	4.81e-04	126	42	3	17897319
Pubmed	The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.	ERCC6 POLR2B	6.47e-04	31	42	2	32355176
Pubmed	The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.	BMP2K BRD4	7.34e-04	33	42	2	19336002
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PLEKHH1 TRIM33 SETDB1 RBM22 LARP6 AKAP17A AP2B1	8.04e-04	1285	42	7	35914814
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	PLD1 ERCC6 AP2B1 POLR2B	9.08e-04	358	42	4	32460013
Pubmed	A complex oscillating network of signaling genes underlies the mouse segmentation clock.	RBM22 EGR1	9.23e-04	37	42	2	17095659
Pubmed	Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.	TRIM33 PLD1 AP2B1	9.79e-04	161	42	3	36398662
Cytoband	3q26	PLD1 TNFSF10	1.71e-05	7	42	2	3q26
Cytoband	4q12	NOA1 POLR2B	1.18e-03	55	42	2	4q12
Cytoband	Ensembl 112 genes in cytogenetic band chr4q12	NOA1 POLR2B	2.72e-03	84	42	2	chr4q12
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-Mast_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BMP2K EGR1 TNFSF10 SVOPL	2.98e-05	189	42	4	7bc6e152fb4fe5cd6db9407929c15843a5d8f8c4
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRPSAP1 SLF1 ITGA5 TNFSF10	3.23e-05	193	42	4	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FMOD GUCY1A1 EGR1 CDH9	3.57e-05	198	42	4	bba40ece261741fa8c0e28de768af001d28f04f8
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FMOD GUCY1A1 EGR1 CDH9	3.64e-05	199	42	4	1f5ad0f1971156b28a8d46a380bda906b5fdbedc
ToppCell	(7)_Mast_cell\|World / shred on Cell_type and subtype	BMP2K EGR1 TNFSF10 SVOPL	3.64e-05	199	42	4	c0b5f1cb435da99a7e2ebac9ee7d7b1bd0e49b42
ToppCell	Sigmoid-Mast_cell\|Sigmoid / Region, Cell class and subclass	BMP2K EGR1 TNFSF10 SVOPL	3.72e-05	200	42	4	025125d8b9c6540d9cdeea7f0fe9c58aec2a16b0
ToppCell	Sigmoid-(7)_Mast_cell\|Sigmoid / shred on region, Cell_type, and subtype	BMP2K EGR1 TNFSF10 SVOPL	3.72e-05	200	42	4	bd8e0f027055bb34e99aa0e271ec3a0912f666bb
ToppCell	Caecum-(7)_Mast_cell\|Caecum / shred on region, Cell_type, and subtype	BMP2K EGR1 TNFSF10 SVOPL	3.72e-05	200	42	4	d23fe8644ce42ace51fcde43cb4cd22a99300c02
ToppCell	Caecum-Mast_cell\|Caecum / Region, Cell class and subclass	BMP2K EGR1 TNFSF10 SVOPL	3.72e-05	200	42	4	8791d0b3d883e7a747a23d21118817f5be4013b6
ToppCell	Caecum-(7)_Mast_cell-(70)_Mast\|Caecum / shred on region, Cell_type, and subtype	BMP2K EGR1 TNFSF10 SVOPL	3.72e-05	200	42	4	9974285c28a633a010c4f24d035ad3685705e881
ToppCell	Transverse-(7)_Mast_cell-(70)_Mast\|Transverse / shred on region, Cell_type, and subtype	BMP2K EGR1 TNFSF10 SVOPL	3.72e-05	200	42	4	aa17354c83b0967707d995e4b74e042ac211f814
ToppCell	Sigmoid-Mast_cell-Mast\|Sigmoid / Region, Cell class and subclass	BMP2K EGR1 TNFSF10 SVOPL	3.72e-05	200	42	4	e7e49e192a86566ed96f1e54657dd2ebc9036d47
ToppCell	Sigmoid-(7)_Mast_cell-(70)_Mast\|Sigmoid / shred on region, Cell_type, and subtype	BMP2K EGR1 TNFSF10 SVOPL	3.72e-05	200	42	4	7224ee639d56509de854203653a85ab09e6f05fe
ToppCell	Transverse-Mast_cell-Mast\|Transverse / Region, Cell class and subclass	BMP2K EGR1 TNFSF10 SVOPL	3.72e-05	200	42	4	0af942a33cc50da65129204976e24203320e206d
ToppCell	Caecum-Mast_cell-Mast\|Caecum / Region, Cell class and subclass	BMP2K EGR1 TNFSF10 SVOPL	3.72e-05	200	42	4	168426e8296697d05684d71989c4eb5bb2a0489f
ToppCell	Transverse-Mast_cell\|Transverse / Region, Cell class and subclass	BMP2K EGR1 TNFSF10 SVOPL	3.72e-05	200	42	4	5e3f5349ffbcabdca3d911fbc99a46aaa56c47c4
ToppCell	Transverse-(7)_Mast_cell\|Transverse / shred on region, Cell_type, and subtype	BMP2K EGR1 TNFSF10 SVOPL	3.72e-05	200	42	4	d90d1d3015a9258298bd6b4ba07971aa1af8b82b
ToppCell	(70)_Mast\|World / shred on Cell_type and subtype	BMP2K EGR1 TNFSF10 SVOPL	3.94e-05	203	42	4	b7af2130b4965661b5a50717a7f82d8d498f8d08
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Unc5b_(MGE-derived_cortical_interneurons--Chandelier_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DNMBP FER1L5 SVOPL	6.60e-05	83	42	3	e7f7ad1cd8b08172ef2432a80554aa8174a6c675
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Unc5b_(MGE-derived_cortical_interneurons--Chandelier_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DNMBP FER1L5 SVOPL	6.60e-05	83	42	3	33fa6e4a01be4d9945b273c884066d4bfdeaa62d
Disease	immature granulocyte count	DEPDC5 SLC44A4	2.29e-04	17	39	2	EFO_0803542
Disease	visual epilepsy (biomarker_via_orthology)	PLD1 EGR1 SYT10	2.32e-04	90	39	3	DOID:11832 (biomarker_via_orthology)
Disease	middle cerebral artery infarction (biomarker_via_orthology)	ERCC6 AP2B1 EGR1	2.55e-04	93	39	3	DOID:3525 (biomarker_via_orthology)
Disease	Glioblastoma Multiforme	TRIM33 TNFSF10 BRD4	4.29e-04	111	39	3	C1621958
Disease	Pseudoaphakia	ERCC6 SLC33A1	4.61e-04	24	39	2	C0524524
Disease	Lens Opacities	ERCC6 SLC33A1	4.61e-04	24	39	2	C1510497
Disease	ovarian neoplasm	ERCC6 TNFSF10 WNT7A	7.43e-04	134	39	3	C0919267
Disease	Malignant neoplasm of ovary	ERCC6 TNFSF10 WNT7A	7.92e-04	137	39	3	C1140680
Disease	melanoma (is_marker_for)	SETDB1 BRD4	8.76e-04	33	39	2	DOID:1909 (is_marker_for)
Disease	Colonic Neoplasms	GUCY1A1 TNFSF10 BRD4	1.07e-03	152	39	3	C0009375
Disease	Cataract	ERCC6 SLC33A1	1.10e-03	37	39	2	C0086543
Disease	Malignant tumor of colon	GUCY1A1 TNFSF10 BRD4	1.22e-03	159	39	3	C0007102
Disease	renal cell carcinoma	PLD1 CRY1	1.42e-03	42	39	2	EFO_0000681
Disease	reticulocyte measurement	PRPSAP1 DEPDC5 PLD1 AP2B1 BMP2K BRD4	2.42e-03	1053	39	6	EFO_0010700

Protein segments in the cluster

Peptide	Gene	Start	Entry
QPLNTFYKAMPYRLL	SLC33A1	371	O00400
YYNMLLKKLAPPLVT	AP2B1	276	P63010
KLNLPDYYKIIKTPM	BRD4	91	O60885
YASLPPKRMYSQLKT	DNMBP	456	Q6XZF7
IKKYTTLSYRAPEMI	BMP2K	221	Q9NSY1
MLLKLARTTPYYKRN	RBM22	146	Q9NW64
MSYTLYSKILGPKPQ	MFSD8	436	Q8NHS3
YKQRLSPKMPRTLSL	ERCC6	461	P0DP91
KDKMITVTRYLPKYP	DEPDC5	866	O75140
NLKYLPFVPSRMKYV	FMOD	96	Q06828
YQSQLIKPSRMRKYP	EGR1	311	P18146
IKTNPRLHTPMYYLL	OR51M1	61	Q9H341
MKLKSLLLRYYPPGI	DAW1	1	Q8N136
KLTYLPYSMLNLKKL	LRRC2	271	Q9BYS8
LPSKMLLVYDLYLSP	LARP6	181	Q9BRS8
YLPILVPSAKKAIYM	GLT8D1	156	Q68CQ7
PLSYPSKMTQRRGYL	GPR101	136	Q96P66
YKALKMPYRILPRQL	ITGA5	961	P08648
TKVKYFIPPSMYRAT	B3GNT4	256	Q9C0J1
PPLTYKRFQTLISKM	CRY1	146	Q16526
IPYFPYSKQSKMRKR	PRPSAP1	96	Q14558
LDRPYYMSKSLLKIL	SLC44A4	681	Q53GD3
YSRNKMSTYLLPILI	CDH9	556	Q9ULB4
AYKTKKPPSLMYNVR	NOA1	676	Q8NC60
PNYYKIIKKPMDLST	TRIM33	991	Q9UPN9
KMDLNYKPLVSSTPY	FER1L5	536	A0AVI2
YTLPKSIQPTIKRMA	FER1L5	1231	A0AVI2
LASYLLKPIQRMGKY	PLEKHG4	856	Q58EX7
IMKSKYRSLSYPFLL	PLD1	706	Q13393
AYMKSSRFLPKPLYT	GSTM4	196	Q03013
LYYPQKPLVTTRSME	POLR2B	751	P30876
KTEFLPTKYRGYMLP	SVOPL	161	Q8N434
YVTAYPNRPMVLLKS	SETDB1	336	Q15047
LCPAYGLYLKPITKM	AKAP17A	16	Q02040
PMTYKSKSEYLIPKQ	CLCA3P	81	Q9Y6N3
MPTYRKLTSLPLYQK	ZFP30	136	Q9Y2G7
TSDPYVKMYLLPDRK	SYT10	266	Q6XYQ8
QIMYYKSPSDVIRKP	PLEKHH1	606	Q9ULM0
PLSLQKMVYSYLPAL	SLF1	701	Q9BQI6
LAKDSPPTPTMYKYR	ZDHHC5	341	Q9C0B5
KPLSYRKPMDTDLVY	WNT7A	256	O00755
YKYTSYPDPILLMKS	TNFSF10	211	P50591
PYLLYSVHMKSTKPS	GUCY1A1	251	Q02108