Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ARM-type_fold	VAC14 DNAJC13 RIPOR2 BZW2 PKP3 UBR4 EIF4G2 FRYL BZW1 CTNND1 XPOT ITPR1	2.42e-08	339	81	12	IPR016024
Domain	eIF5C	BZW2 EIF4G2 BZW1	2.72e-06	7	81	3	SM00515
Domain	W2	BZW2 EIF4G2 BZW1	2.72e-06	7	81	3	PF02020
Domain	W2	BZW2 EIF4G2 BZW1	2.72e-06	7	81	3	PS51363
Domain	W2_domain	BZW2 EIF4G2 BZW1	2.72e-06	7	81	3	IPR003307
Domain	Med13_N	MED13L MED13	1.86e-05	2	81	2	PF11597
Domain	Mediator_Med13_N_met/fun	MED13L MED13	1.86e-05	2	81	2	IPR021643
Domain	Mediator_Med13	MED13L MED13	1.86e-05	2	81	2	IPR009401
Domain	Med13_C	MED13L MED13	1.86e-05	2	81	2	PF06333
Domain	MIF4-like	BZW2 EIF4G2 BZW1	3.44e-05	15	81	3	IPR016021
Domain	-	BZW2 EIF4G2 BZW1	3.44e-05	15	81	3	1.25.40.180
Domain	-	VAC14 DNAJC13 RIPOR2 PKP3 FRYL CTNND1 XPOT	5.03e-05	222	81	7	1.25.10.10
Domain	ARM-like	VAC14 DNAJC13 RIPOR2 PKP3 FRYL CTNND1 XPOT	1.71e-04	270	81	7	IPR011989
Domain	-	ASAP2 DNMBP ASAP1	2.93e-04	30	81	3	1.20.1270.60
Domain	AH/BAR-dom	ASAP2 DNMBP ASAP1	2.93e-04	30	81	3	IPR027267
Domain	Plakophilin/d_Catenin	PKP3 CTNND1	3.85e-04	7	81	2	IPR028435
Domain	LAM_G_DOMAIN	EYS CNTNAP5 LAMA4	5.94e-04	38	81	3	PS50025
Domain	Laminin_G_2	EYS CNTNAP5 LAMA4	6.92e-04	40	81	3	PF02210
Domain	LamG	EYS CNTNAP5 LAMA4	9.16e-04	44	81	3	SM00282
Domain	IBR	RNF144B RNF216	1.63e-03	14	81	2	SM00647
Domain	TBC_RABGAP	TBC1D32 RABGAP1L TBC1D8B	1.75e-03	55	81	3	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D32 RABGAP1L TBC1D8B	1.75e-03	55	81	3	IPR000195
Domain	IBR_dom	RNF144B RNF216	1.88e-03	15	81	2	IPR002867
Domain	Laminin_G	EYS CNTNAP5 LAMA4	2.04e-03	58	81	3	IPR001791
Domain	ArfGap	ASAP2 ASAP1	6.99e-03	29	81	2	SM00105
Domain	ArfGap	ASAP2 ASAP1	6.99e-03	29	81	2	PF01412
Domain	ARFGAP	ASAP2 ASAP1	6.99e-03	29	81	2	PS50115
Domain	ArfGAP	ASAP2 ASAP1	6.99e-03	29	81	2	IPR001164
Domain	Arm	PKP3 CTNND1	7.96e-03	31	81	2	PF00514
Domain	-	EYS CNTNAP5 LAMA4	8.17e-03	95	81	3	2.60.120.200
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ZNF487 RIPOR2 PTPN13 EIF4G2 DZIP3 PTPN23 TMEM39B FRYL CHD7 ZMYM1 GPATCH8 CPLANE1 MAP3K3 ASAP1 CSTPP1 XPOT ITPR1	1.15e-09	1084	86	17	11544199
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DNAJC13 CCDC22 UBR4 EIF4G2 SF3A3 POLRMT SMC4 PTPN23 CHD7 DDX60L CDK1 CTNND1 MCM10 DDB1 NUP160 ASAP1 XPOT	3.04e-08	1353	86	17	29467282
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	PTPN13 BZW2 EIF4G2 SMC4 ANKRD26 PTPN23 CDK1 BZW1 CTNND1 DDB1 CLCC1 CSTPP1	1.79e-07	708	86	12	39231216
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	DNAJC13 PTPN13 CCDC22 BZW2 PTPN23 CDK1 MAPK3 CTNND1 CSPP1 CLCC1 ASAP1 CTDSP2 XPOT ITPR1	2.85e-07	1049	86	14	27880917
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CCDC22 BZW2 UBR4 EIF4G2 SF3A3 POLRMT SMC4 SSB DDX60L CDK1 BZW1 ADAM10 DDB1 CLCC1 XPOT ITPR1	4.30e-07	1440	86	16	30833792
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TBC1D32 ASAP2 DNAJC13 PTPN13 BZW2 RABGAP1L DZIP3 SF3A3 SMC4 PDE5A SSB BZW1 CSPP1 NUP160 MAP3K3	7.91e-07	1321	86	15	27173435
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	BZW2 PKP3 UBR4 SF3A3 POLRMT SMC4 PTPN23 CDK1 BZW1 MAPK3 DDB1 NUP160 XPOT	7.93e-07	974	86	13	28675297
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	PTPN13 UBR4 SF3A3 SMC4 GPATCH8 INPP5F CTNND1 XPOT	1.14e-06	313	86	8	38270169
Pubmed	Tagging genes with cassette-exchange sites.	RABGAP1L UBR4 ZMYM1 BZW1 MAPK3 GPATCH8 MCM10 XPOT	1.88e-06	335	86	8	15741177
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DNAJC13 UBR4 FRYL BZW1 CTNND1	2.59e-06	87	86	5	12465718
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	DNAJC13 UBR4 EIF4G2 SMC4 PTPN23 SSB CDK1 DDB1 NUP160 XPOT	4.07e-06	638	86	10	33239621
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	VAC14 BZW2 SF3A3 SMC4 SSB CDK1 BZW1 DDX55 DDB1 XPOT	5.00e-06	653	86	10	33742100
Pubmed	Inositol 1,4,5-trisphosphate receptor (type 1) phosphorylation and modulation by Cdc2.	CDK1 ITPR1	6.04e-06	2	86	2	14635192
Pubmed	Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation.	BZW2 BZW1	6.04e-06	2	86	2	36333315
Pubmed	Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse.	MED13L MED13	6.04e-06	2	86	2	29325037
Pubmed	Translational autoregulation of BZW1 and BZW2 expression by modulating the stringency of start codon selection.	BZW2 BZW1	6.04e-06	2	86	2	29470543
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	DNAJC13 UBR4 EIF4G2 SF3A3 SMC4 PTPN23 FRYL SSB HAGH DDB1 NUP160 CLCC1 ASAP1 CSTPP1	6.33e-06	1367	86	14	32687490
Pubmed	Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes.	DET1 MDM2 DDB1	6.50e-06	15	86	3	17452440
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	UBR4 EIF4G2 SMC4 SSB CDK1 BZW1 CTNND1 DDB1	6.80e-06	399	86	8	37536630
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	DNAJC13 RABGAP1L TMEM39B FRYL CHD7 CTNND1 MED13L MED13 ITPR1	7.37e-06	536	86	9	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	DNAJC13 RABGAP1L TMEM39B FRYL CHD7 CTNND1 MED13L MED13 ITPR1	7.59e-06	538	86	9	10512203
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	BZW2 UBR4 PTPN23 CDK1 MAPK3 CTNND1 MDM2	7.63e-06	288	86	7	23383273
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UNC13B RIPOR2 RABGAP1L DZIP3 GPATCH8 MED13L ASAP1 EPG5	7.86e-06	407	86	8	12693553
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	TBC1D32 NACC1 UBR4 SF3A3 POLRMT SMC4 TWNK CTNND1 MDM2 PBX3 NUP160	8.69e-06	857	86	11	25609649
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	PKP3 UBR4 EIF4G2 SF3A3 SMC4 PTPN23 SSB HAGH CDK1 BZW1 CTNND1 DDX55 DDB1 XPOT	9.35e-06	1415	86	14	28515276
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	DNAJC13 PTPN13 NACC1 UBR4 POLRMT CHD7 INPP5F CSTPP1	9.54e-06	418	86	8	34709266
Pubmed	DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC.	MRPL48 POLRMT CTNND1 DDB1 ITPR1	1.15e-05	118	86	5	37105989
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CCDC22 SF3A3 CHD7 ZMYM1 BZW1 GPATCH8 CTNND1 MCM10 DDB1 CLCC1	1.36e-05	733	86	10	34672954
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	POLRMT SSB CDK1 GPATCH8 CTNND1 DDX55 NUP160 ITPR1	1.38e-05	440	86	8	34244565
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DNAJC13 PKP3 SF3A3 SMC4 CHD7 CDK1 BZW1 CTNND1 DDB1	1.42e-05	582	86	9	20467437
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	VAC14 ASAP2 BZW2 UBR4 ASB3 EIF4G2 SF3A3 SMC4 FRYL SSB BZW1 GPATCH8 NUP160	1.59e-05	1284	86	13	17353931
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	DNAJC13 PKP3 UBR4 POLRMT SMC4 PTPN23 HAGH CDK1 BZW1 DDX55 ADAM10 NUP160 XPOT	1.76e-05	1297	86	13	33545068
Pubmed	Differences in phosphorylation of human and chicken stathmin by MAP kinase.	CDK1 MAPK3	1.81e-05	3	86	2	11135364
Pubmed	Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.	BZW2 BZW1	1.81e-05	3	86	2	34260931
Pubmed	Cdc2/cyclin B1 interacts with and modulates inositol 1,4,5-trisphosphate receptor (type 1) functions.	CDK1 ITPR1	1.81e-05	3	86	2	16237118
Pubmed	PBX3 promotes migration and invasion of colorectal cancer cells via activation of MAPK/ERK signaling pathway.	MAPK3 PBX3	1.81e-05	3	86	2	25561793
Pubmed	Sinomenine Suppressed Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis by Regulating lncRNA XIST.	EIF4G2 MDM2	1.81e-05	3	86	2	35960313
Pubmed	DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis.	EIF4G2 CDK1	1.81e-05	3	86	2	18450493
Pubmed	Phosphorylation of smooth muscle caldesmon by mitogen-activated protein (MAP) kinase and expression of MAP kinase in differentiated smooth muscle cells.	CDK1 MAPK3	1.81e-05	3	86	2	1331069
Pubmed	HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.	MCM10 DDB1	1.81e-05	3	86	2	26032416
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	ASAP2 RABGAP1L MRPL48 SF3A3 POLRMT SMC4 TWNK CHD7 SSB CDK1 MAPK3 DDB1	2.66e-05	1153	86	12	29845934
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	SF3A3 SMC4 CDK1 GPATCH8 CTNND1 DDB1	3.30e-05	244	86	6	29884807
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	EIF4G2 SMC4 CHD7 MDM2 ASAP1 XPOT ITPR1	3.37e-05	363	86	7	14691545
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	UBR4 POLRMT SMC4 FRYL CHD7 SSB DDB1 NUP160 XPOT	3.49e-05	653	86	9	22586326
Pubmed	Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.	MAPK3 MAP3K3	3.61e-05	4	86	2	15964803
Pubmed	Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity.	CDK1 MAPK3	3.61e-05	4	86	2	9525956
Pubmed	Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10.	CDK1 MAPK3	3.61e-05	4	86	2	9126608
Pubmed	COP1D, an alternatively spliced constitutive photomorphogenic-1 (COP1) product, stabilizes UV stress-induced c-Jun through inhibition of full-length COP1.	DET1 DDB1	3.61e-05	4	86	2	17968316
Pubmed	Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.	ASAP2 ASAP1	3.61e-05	4	86	2	12149250
Pubmed	FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.	MED13L MED13	3.61e-05	4	86	2	29809150
Pubmed	Mitotic Golgi translocation of ERK1c is mediated by a PI4KIIIβ-14-3-3γ shuttling complex.	CDK1 MAPK3	3.61e-05	4	86	2	26459638
Pubmed	JAK2(V617F) negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasms.	SSB MDM2	3.61e-05	4	86	2	21785463
Pubmed	Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration.	BZW2 BZW1	3.61e-05	4	86	2	33494375
Pubmed	Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.	PKP3 CDK1 MAPK3 CTNND1	3.70e-05	75	86	4	15951569
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	NACC1 UBR4 EIF4G2 SMC4 CDK1 BZW1 GPATCH8 CTNND1 MED13L DDB1 MED13	4.08e-05	1014	86	11	32416067
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	UBR4 EIF4G2 SF3A3 POLRMT SMC4 SSB CDK1 BZW1 CTNND1 DDX55 DDB1 NUP160 XPOT	4.67e-05	1425	86	13	30948266
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	PTPN13 ANKRD26 CDK1 CTNND1 DNMBP CSTPP1	5.01e-05	263	86	6	34702444
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	BZW2 UBR4 SF3A3 SMC4 PTPN23 FRYL SSB CDK1 BZW1 DNMBP DDB1 NUP160 XPOT	5.78e-05	1455	86	13	22863883
Pubmed	Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.	BZW2 BZW1	6.01e-05	5	86	2	27325740
Pubmed	Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator.	CDK1 MAPK3	6.01e-05	5	86	2	18245089
Pubmed	The Vascular Endothelial Growth Factor-A phosphorylates Murine Double Minute-2 on its Serine 166 via the Extracellular Signal-Regulated Kinase 1/2 and p90 Ribosomal S6 Kinase in primary human endothelial cells.	MAPK3 MDM2	6.01e-05	5	86	2	27591897
Pubmed	Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis.	MAPK3 CTNND1	6.01e-05	5	86	2	32010791
Pubmed	Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2.	CDK1 MAPK3	6.01e-05	5	86	2	8376365
Pubmed	Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals.	POLRMT TWNK	6.01e-05	5	86	2	29132502
Pubmed	Hip2 ubiquitin-conjugating enzyme overcomes radiation-induced G2/M arrest.	CDK1 MDM2	6.01e-05	5	86	2	23933584
Pubmed	Phosphodiesterase-5 inhibition abolishes neuron apoptosis induced by chronic hypoxia independently of hypoxia-inducible factor-1alpha signaling.	PDE5A MAPK3	6.01e-05	5	86	2	18641057
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	RABGAP1L POLRMT SMC4 SSB DDX55 DDB1 ASAP1 XPOT	6.44e-05	547	86	8	37267103
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	PTPN13 ANKRD26 CTNND1 CSPP1 CSTPP1	6.47e-05	169	86	5	31462741
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJC13 PTPN13 UBR4 MRPL48 EIF4G2 POLRMT ANKRD26 TWNK CTNND1 CSPP1 DDB1 CLCC1 ITPR1	7.20e-05	1487	86	13	33957083
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	BZW2 EIF4G2 SMC4 BZW1 DDB1 NUP160 CLCC1 XPOT	7.58e-05	560	86	8	35241646
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	TWNK TACR2 CDK1 INPP5F MCM10 DNMBP CC2D2B	7.83e-05	415	86	7	16385451
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	BZW2 NACC1 EIF4G2 SMC4 CHD7 SSB CDK1 BZW1 MED13L DDX55 XPOT	8.65e-05	1103	86	11	34189442
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	UNC13B VAC14 UBR4 POLRMT TWNK ZFYVE26 FRYL MED13L DNMBP MED13 CTDSP2	8.79e-05	1105	86	11	35748872
Pubmed	CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.	MCM10 DDB1	9.01e-05	6	86	2	22570418
Pubmed	Chromosome condensation by a human condensin complex in Xenopus egg extracts.	SMC4 CDK1	9.01e-05	6	86	2	11136719
Pubmed	Dynamic expression of the RNA-binding protein Sam68 during mouse pre-implantation development.	CDK1 MAPK3	9.01e-05	6	86	2	18321792
Pubmed	Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.	DET1 DDB1	9.01e-05	6	86	2	14739464
Pubmed	Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3.	PKP3 CTNND1	9.01e-05	6	86	2	27375112
Pubmed	Phosphorylation of HIV-1 Rev protein: implication of protein kinase CK2 and pro-directed kinases.	CDK1 MAPK3	9.01e-05	6	86	2	8806671
Pubmed	Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF.	ASAP2 ASAP1	9.01e-05	6	86	2	18786926
Pubmed	Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death.	CDK1 MAPK3	9.01e-05	6	86	2	15788397
Pubmed	Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase.	CDK1 MAPK3	9.01e-05	6	86	2	8325880
Pubmed	Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates.	DET1 DDB1	9.01e-05	6	86	2	32041890
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	ASB3 SF3A3 CHD7 CDK1 MAPK3 PBX3 DDB1 NUP160	1.00e-04	583	86	8	29844126
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	UNC13B DNAJC13 BZW2 NACC1 MRPL48 SSB BZW1 MAPK3 CTNND1 XPOT	1.01e-04	931	86	10	27432908
Pubmed	A Novel Mechanism for NF-κB-activation via IκB-aggregation: Implications for Hepatic Mallory-Denk-Body Induced Inflammation.	PTPN13 POLRMT SMC4	1.07e-04	37	86	3	32912968
Pubmed	Network organization of the human autophagy system.	RABGAP1L DZIP3 POLRMT TWNK CTNND1 DDB1 XPOT	1.08e-04	437	86	7	20562859
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	PTPN13 NACC1 ANKRD26 FRYL INPP5F CSPP1 NUP160	1.22e-04	446	86	7	24255178
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	DNAJC13 PKP3 UBR4 MRPL48 POLRMT CDK1 CTNND1 XPOT	1.23e-04	601	86	8	33658012
Pubmed	BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation.	CDK1 MAPK3	1.26e-04	7	86	2	15735702
Pubmed	Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation.	DET1 DDB1	1.26e-04	7	86	2	30405104
Pubmed	Functional genomic screen for modulators of ciliogenesis and cilium length.	PTPN23 ASAP1	1.26e-04	7	86	2	20393563
Pubmed	The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.	MED13L MED13	1.26e-04	7	86	2	12093747
Pubmed	CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL.	CDK1 MAPK3	1.26e-04	7	86	2	21924351
Pubmed	ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.	ASAP2 ASAP1	1.26e-04	7	86	2	9819391
Pubmed	CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.	ASAP2 ASAP1	1.26e-04	7	86	2	17255943
Pubmed	HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.	CDK1 MDM2	1.26e-04	7	86	2	23430691
Pubmed	Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases.	CDK1 MAPK3	1.26e-04	7	86	2	10383391
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DNAJC13 NACC1 PKP3 EIF4G2 CHD7 MAPK3 GPATCH8 DNMBP MED13	1.28e-04	774	86	9	15302935
Pubmed	Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.	ASAP2 SF3A3 BZW1 DNMBP	1.43e-04	106	86	4	18654987
Interaction	PHF21A interactions	DNAJC13 PTPN13 RABGAP1L UBR4 DZIP3 POLRMT CHD7 INPP5F DDB1 CSTPP1	1.62e-06	343	84	10	int:PHF21A
Interaction	ATG16L1 interactions	PTPN13 CCDC22 DET1 MRPL48 EIF4G2 SMC4 MAPK3 GPATCH8 CTNND1 DDX55 DNMBP TBC1D8B CSPP1 DDB1 NUP160 CSTPP1 ITPR1	4.91e-06	1161	84	17	int:ATG16L1
Interaction	SIRT6 interactions	POLRMT SMC4 SSB CDK1 MAPK3 GPATCH8 CTNND1 DDX55 MDM2 DDB1 NUP160 ITPR1	1.10e-05	628	84	12	int:SIRT6
Interaction	KCNA3 interactions	ASAP2 PTPN13 BZW2 ABCA13 EIF4G2 SMC4 ANKRD26 PTPN23 CDK1 BZW1 CTNND1 DDB1 CLCC1 CSTPP1	1.36e-05	871	84	14	int:KCNA3
Interaction	RAB9A interactions	VAC14 DNAJC13 RABGAP1L ANKRD26 PTPN23 ZFYVE26 HAGH INPP5F CTNND1 CLCC1 XPOT	3.57e-05	595	84	11	int:RAB9A
Interaction	RCOR1 interactions	DNAJC13 PTPN13 RABGAP1L UBR4 DZIP3 POLRMT SMC4 CHD7 BZW1 CSTPP1	3.89e-05	494	84	10	int:RCOR1
GeneFamily	DNA helicases	TWNK CHD7	1.16e-03	17	54	2	1167
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	ASAP2 ASAP1	1.16e-03	17	54	2	1291
GeneFamily	Protein tyrosine phosphatases, non-receptor type	PTPN13 PTPN23	1.30e-03	18	54	2	812
GeneFamily	Cyclins\|Mediator complex	MED13L MED13	4.36e-03	33	54	2	1061
GeneFamily	ArfGAPs	ASAP2 ASAP1	4.36e-03	33	54	2	395
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	DOK5 ASAP2 DNAJC13 PTPN13 RABGAP1L FRYL GPATCH8 INPP5F MED13L PBX3 DNMBP ADAM10 NUP160 MED13 ITPR1	1.14e-07	856	86	15	M4500
Coexpression	DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP	RIPOR2 DET1 DZIP3 FRYL CHD7 MED13L DNMBP ADAM10	1.63e-05	340	86	8	M2012
Coexpression	LAKE_ADULT_KIDNEY_C15_CONNECTING_TUBULE	PTPN13 RABGAP1L CAMKMT MED13L ADAM10 ITPR1	2.16e-05	171	86	6	M39234
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	ASAP2 DNAJC13 FRYL INPP5F MED13L PBX3 DNMBP ADAM10 MED13	2.25e-05	466	86	9	M13522
Coexpression	NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP	RIPOR2 EIF4G2 SF3A3 TWNK FRYL CTNND1 CSPP1 NUP160 CLCC1	2.61e-05	475	86	9	M40979
Coexpression	GSE22611_UNSTIM_VS_2H_MDP_STIM_MUTANT_NOD2_TRANSDUCED_HEK293T_CELL_DN	RNF144B RIPOR2 NACC1 TMEM39B FRYL CTDSP2	3.46e-05	186	86	6	M8175
Coexpression	GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_DN	BZW2 ZNF366 BZW1 PBX3 RNF139 ASAP1	4.38e-05	194	86	6	M10017
Coexpression	SAGIV_CD24_TARGETS_UP	DNAJC13 SMC4 FRYL	5.02e-05	22	86	3	M4144
Coexpression	GSE36826_NORMAL_VS_STAPH_AUREUS_INF_IL1R_KO_SKIN_DN	SMC4 ZMYM1 DNMBP ADAM10 MAP3K3 XPOT	5.04e-05	199	86	6	M9532
Coexpression	GSE24210_CTRL_VS_IL35_TREATED_TCONV_CD4_TCELL_UP	CAMKMT MED13L RNF139 ERMARD MAP3K3 ITPR1	5.18e-05	200	86	6	M7841
Coexpression	GSE7852_LN_VS_FAT_TREG_UP	BZW2 RABGAP1L SMC4 INPP5F NUP160 XPOT	5.18e-05	200	86	6	M5739
Coexpression	GSE6674_ANTI_IGM_VS_CPG_STIM_BCELL_UP	RIPOR2 ASB3 GPATCH8 MAP3K3 ASAP1 CTDSP2	5.18e-05	200	86	6	M6927
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	RIPOR2 RABGAP1L UBR4 EIF4G2 DZIP3 RNF216 FRYL SSB BZW1 GPATCH8 RNF139 MED13 ASAP1 EPG5 ITPR1	9.48e-05	1492	86	15	M40023
Coexpression	ALCALAY_AML_BY_NPM1_LOCALIZATION_UP	UNC13B SMC4 CHD7 CTNND1 PBX3	9.96e-05	140	86	5	M9377
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000	TBC1D32 DNAJC13 DZIP3 RNF216 PDE5A ZMYM1 TEX15 GPATCH8 MCM10 CPLANE1 ERMARD CSPP1 NUP160 XPOT	3.28e-06	810	84	14	gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ASAP2 ABCA13 SMC4 CDK1 MDM2 CPLANE1 CSPP1	1.00e-07	194	86	7	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RIPOR2 PTPN13 PLCXD2 PKP3 SMC4	2.09e-05	172	86	5	1aecc98a3eadabae0f1f328091a9733d916017ec
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KY PDE5A FRYL MCM10 XPOT	2.21e-05	174	86	5	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	facs-MAT-Fat-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 BZW2 PLCXD2 SMC4 CHD7	2.40e-05	177	86	5	b5c20c1247f11ebc97e9cb47482564cd74e36ca6
ToppCell	facs-Kidney-nan-3m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF144B MYH6 ABCA13 EIF4G2 DDB1	2.74e-05	182	86	5	4c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POLRMT CAMKMT CDK1 PBX3 MED13	2.81e-05	183	86	5	3ef9ac1ae13b6172f9121ab1c129ecaa0fef460f
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYH6 ZNF366 CDK1 MCM10 IL3RA	2.89e-05	184	86	5	fa38d6a8709f520a027ad7e3ff783c84187ec467
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EIF4G2 SF3A3 CHD7 CDK1 BZW1	3.20e-05	188	86	5	8bd6f2cd1aadbd6f9ed31b160f59c1eff144e1dc
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	UNC13B PTPN13 RABGAP1L CAMKMT MED13L	4.09e-05	198	86	5	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SMC4 CHD7 CDK1 MCM10 CTDSP2	4.19e-05	199	86	5	53b3d35767889a152f1f38e8f6f0ba8f7a7690f2
ToppCell	NS-moderate-d_0-4-Epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ABCA13 EIF4G2 CTNND1 MDM2 CPLANE1	4.29e-05	200	86	5	64462a18afca3c1a8548a857924b8166058bf958
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW12-Stem_cells\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	DOK5 SMC4 CHD7 CDK1 CHRFAM7A	4.29e-05	200	86	5	4a57d6ba1531ce4e263daccd5de487977e6a1fdd
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW12-Stem_cells-Stem_cells\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	DOK5 SMC4 CHD7 CDK1 CHRFAM7A	4.29e-05	200	86	5	b706526b9c3485889a31253a1ffd017ad3f3fddc
Drug	Asiaticoside [16830-15-2]; Down 200; 4.2uM; MCF7; HT_HG-U133A	UNC13B PKP3 RNF216 CTNND1 MED13L DNMBP ADAM10 ASAP1	6.87e-07	195	85	8	7004_DN
Disease	unipolar depression, neuroticism measurement	EYS ZNF366 PBX3	4.47e-05	24	85	3	EFO_0003761, EFO_0007660
Disease	YKL40 measurement, cerebrospinal fluid biomarker measurement	EYS CNTNAP5	8.15e-05	5	85	2	EFO_0004869, EFO_0006794
Disease	Inherited neuropathies	TWNK ZFYVE26 ITPR1	2.11e-04	40	85	3	C0598589
Disease	phosphatidylcholine 36:1 measurement	TMEM229A CDK1	3.64e-04	10	85	2	EFO_0010379
Disease	obesity (implicated_via_orthology)	HPR ANKRD26 MED13L MED13 ITPR1	4.01e-04	215	85	5	DOID:9970 (implicated_via_orthology)
Disease	urate measurement, bone density	EYS CNTNAP5 TMEM229A RABGAP1L ASB3 EIF4G2 CAMKMT ITPR1	4.18e-04	619	85	8	EFO_0003923, EFO_0004531
Disease	Cardiomyopathies	MYH6 LAMA4 MAPK3 EPG5	5.53e-04	130	85	4	C0878544
Disease	unipolar depression, mood disorder	EYS RABGAP1L NUP160 CSTPP1	6.19e-04	134	85	4	EFO_0003761, EFO_0004247
Disease	irritable bowel syndrome symptom measurement	HAGH DDX60L CHRFAM7A	6.35e-04	58	85	3	EFO_0021536
Disease	neutrophil collagenase measurement	ABCA13 DNMBP	9.59e-04	16	85	2	EFO_0008248
Disease	pancreatic ductal carcinoma (is_implicated_in)	MAPK3 MDM2	9.59e-04	16	85	2	DOID:3587 (is_implicated_in)
Disease	feeling miserable measurement	RABGAP1L NUP160 CSTPP1	1.56e-03	79	85	3	EFO_0009598
Disease	Joubert syndrome 1	CPLANE1 CSPP1	1.66e-03	21	85	2	C4551568
Disease	Immunologic Deficiency Syndromes	CHD7 EPG5	1.99e-03	23	85	2	C0021051
Disease	pulse pressure measurement	MYH6 VAC14 ASAP2 ASB3 SF3A3 FRYL GPATCH8 CTNND1 MED13L PBX3 NUP160	2.14e-03	1392	85	11	EFO_0005763
Disease	retinitis pigmentosa (implicated_via_orthology)	EYS EPG5	2.75e-03	27	85	2	DOID:10584 (implicated_via_orthology)
Disease	alcohol use disorder measurement, alcohol consumption measurement	RABGAP1L CAMKMT NUP160	2.80e-03	97	85	3	EFO_0007878, EFO_0009458

Protein segments in the cluster

Peptide	Gene	Start	Entry
CQYYLLKNEQFLSHL	EPG5	1071	Q9HCE0
ILLQKVQEYCYDNIH	BZW2	341	Q9Y6E2
LLLKIQEYCYDNIHF	BZW1	341	Q7L1Q6
GQELQYIYFIHSLCL	TBC1D32	421	Q96NH3
TCQLYIQTDHLFFKY	ADAM10	221	O14672
ELCYNQIKYDLTHNF	ABCA13	4626	Q86UQ4
YKIYCQNHDEAIALL	DNMBP	866	Q6XZF7
LISECNHLKERQYQY	ANKRD26	1196	Q9UPS8
AYKYLAALHENCSQL	CCDC22	556	O60826
CDKVVLSHNQGLYLY	DET1	211	Q7L5Y6
NKEEHAILLCNFFLY	CC2D2B	1181	Q6DHV5
ILVYCLNHYKGDENI	CHD7	1646	Q9P2D1
KYEQACILYNLGALH	PTPN23	111	Q9H3S7
YCLQNLDNDIFLRHY	RNF144B	221	Q7Z419
QIYHTELEKYEQACN	PBX3	161	P40426
QKYNVLFVGYCLSHD	MED13L	1821	Q71F56
QLFIENGTLKYHFYC	EYS	1936	Q5T1H1
KICHQIEYYFGDFNL	SSB	16	P05455
PEVKIAYINFLNHCY	ITPR1	1426	Q14643
NCYQNFLDYHRCLKT	COX6B2	31	Q6YFQ2
RVYCGHEYTINNLKF	HAGH	216	Q16775
ANGYVEHLFRYQCKN	HPR	41	P00739
VLENANHNFYSYILK	KY	641	Q8NBH2
LLQNLIKYFHAQCNF	ASAP2	216	O43150
VSYVQAYAKHECNLI	DDX55	426	Q8NHQ9
HQYIAKCLKYLGFND	DDX60L	676	Q5H9U9
PLNAYVLNFYKHNCL	DDX60L	1621	Q5H9U9
FYCELCDKQYQKHQE	GPATCH8	136	Q9UKJ3
YLAFCGIVLHNAQLY	PDE5A	306	O76074
KYNLQLQHYCERDNL	CSPP1	856	Q1MSJ5
YKLHFQLLLLFQAYC	FRYL	2836	O94915
AYFRCYHKVTELNNV	DOK5	51	Q9P104
QQLSNDHICYFLYQI	MAPK3	136	P27361
YCQYHVQAQYKKLSA	MCM10	411	Q7L590
YVYDICHVIIDNLQF	TWNK	506	Q96RR1
LQVSALYALQVHCYN	EIF4G2	826	P78344
MQKYCIYQHFQFQLL	CHRFAM7A	1	Q494W8
QLYKLHYQCEDFKRQ	DZIP3	756	Q86Y13
YRNNFEDLHCKFYQL	RABGAP1L	656	Q5R372
SNIIHYFYCEILQLF	OR5AC1	171	P0C628
GAQINELHLAYCLKY	ASB3	341	Q9Y575
NVANRRQQYECLHYK	IL3RA	141	P26951
LFYQCLENLCDRHKY	CSTPP1	201	Q9H6J7
LLYCHLYSYNLNDAQ	CPLANE1	876	Q9H799
KSDLLQCLQYQFYQI	CTDSP2	71	O14595
LLQNLIKYYHAQCNF	ASAP1	236	Q9ULH1
IKYYHAQCNFFQDGL	ASAP1	241	Q9ULH1
QLENELFCNIYYLKQ	DNAJC13	1246	O75165
CGKNAHEYQQYLKFV	ERMARD	606	Q5T6L9
AYFCAHFEEQLNIYK	INPP5F	356	Q9Y2H2
GQVQALQNHYRKYLC	POLRMT	521	O00411
AVKSNAAAYLQHLCY	CTNND1	381	O60716
AAAYLQHLCYRNDKV	CTNND1	386	O60716
TECNHYNNIMALYLK	DDB1	901	Q16531
QEDIYCHKFIQQVYL	TACR2	276	P21452
FLKKNFHGCIENLYY	CNTNAP5	321	Q8WYK1
LKNLQHERIVQYYGC	MAP3K3	416	Q99759
YLLHLCSYQHKFQLQ	PTPN13	856	Q12923
LNNDVISLYNFKHIY	LAMA4	1011	Q16363
CLHAYFNIYLQAKNG	RNF139	501	Q8WU17
CFLTQNYRHAYDLIQ	VAC14	636	Q08AM6
LQYVLALYHCQVFLK	TMEM229A	161	B2RXF0
YNKFHNNCYRDTLIV	SLC6A5	491	Q9Y345
LYDEKQQHIVYCSND	MDM2	66	Q00987
YAQYVHNLCNSLSIK	MRPL48	106	Q96GC5
IIHFKNYYDLNVLCN	RNF216	306	Q9NWF9
KYNVLFVGYCLSHDQ	MED13	1786	Q9UHV7
FQLKAERNYHIFYQI	MYH6	276	P13533
LERYKVQNNLYHHCV	NUP160	1296	Q12769
NQHFREKALLYYCEA	RIPOR2	971	Q9Y4F9
KSYLYQILQGIVFCH	CDK1	106	P06493
EEVLAYYCLKHNNIF	CAMKMT	131	Q7Z624
YYCLKHNNIFRALAV	CAMKMT	136	Q7Z624
YLYKLAFAQHQAEVA	CLCC1	231	Q96S66
QYNLQYHPLILECKY	C10orf82	81	Q8WW14
QVLGAAYIQHKCYSD	PKP3	336	Q9Y446
YQIDCQQFRALYHLL	TBC1D8B	836	Q0IIM8
NCQVLIFYHCPFYKQ	PLCXD2	206	Q0VAA5
HVCQYYIYELQKRIA	SMC4	321	Q9NTJ3
FNNCHDLYSRQYQLK	UNC13B	936	O14795
AYQCHLCYKSFVQKQ	ZNF366	476	Q8N895
NIIGFCYDYLHILKQ	XPOT	346	O43592
LYKLHGLNINYNCEI	SF3A3	396	Q12874
YEVKYQNVKHNLCSN	ZMYM1	201	Q5SVZ6
LKYNAFCELQTYHDQ	TEX15	1751	Q9BXT5
YEKLITGCYNILANH	UBR4	1351	Q5T4S7
ACQHLQKKNYYHILY	ZFYVE26	2241	Q68DK2
FCQLIALFVHYINIY	TMEM39B	86	Q9GZU3
QYIQTLKQCFEYNHR	ZNF487	236	B1APH4
AYSNYHVKQFLEALL	ZBTB8B	271	Q8NAP8
VLHAVKYYCQNFAPN	NACC1	436	Q96RE7