Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity

PDE1A PDE1C

1.30e-0431322GO:0048101
GeneOntologyMolecularFunctioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

PDE1A PDE1C

1.30e-0431322GO:0004117
GeneOntologyMolecularFunctionDNA topoisomerase binding

SETMAR TOPORS

2.58e-0441322GO:0044547
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

LPIN1 TACC1 ASXL2

3.44e-04211323GO:0042975
DomainCFC

CFC1 CFC1B

1.53e-0431342PF09443
DomainCryptic/Cripto_CFC-dom

CFC1 CFC1B

1.53e-0431342IPR019011
DomainPDEase_N

PDE1A PDE1C

1.53e-0431342IPR013706
DomainPDEase_I_N

PDE1A PDE1C

1.53e-0431342PF08499
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

EPN3 LRWD1 GBF1 INPPL1 ADGRB2 LAMA5 IRS1 AHDC1 ADCY7 SH3BP4 TBC1D16 DST PER2 CSAD ANKRD11 PKN1 PLCG1 FUT1 PLXNA1

7.57e-0811051371935748872
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CYLD GBF1 INPPL1 IRS1 FAM53C ITPKB SH3BP4 FSIP2 DST PRKAA2 ANKRD11 NHS CDC25B SRRM2 WDR62 DOP1B

3.16e-078611371636931259
Pubmed

Role for Fes/Fps tyrosine kinase in microtubule nucleation through is Fes/CIP4 homology domain.

PBRM1 FES

1.54e-052137214551201
Pubmed

The Frequency and Clinical Implication of ROS1 and RET Rearrangements in Resected Stage IIIA-N2 Non-Small Cell Lung Cancer Patients.

RET ROS1

1.54e-052137225905642
Pubmed

The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer.

CFC1 CFC1B

1.54e-052137211174844
Pubmed

The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma.

RET PLCG1

1.54e-05213728628282
Pubmed

Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis.

PDE1A PDE1C

1.54e-052137211369604
Pubmed

C1r Upregulates Production of Matrix Metalloproteinase-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma.

C1R MMP13

1.54e-052137234756877
Pubmed

Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity.

EXTL1 ITGAX

1.54e-052137236656709
Pubmed

From genotype to phenotype: Are there imaging characteristics associated with lung adenocarcinomas harboring RET and ROS1 rearrangements?

RET ROS1

1.54e-052137226424208
Pubmed

LPIN1 promotes epithelial cell transformation and mammary tumourigenesis via enhancing insulin receptor substrate 1 stability.

IRS1 LPIN1

1.54e-052137227729374
Pubmed

Association study of FLT4 and HYDIN single nucleotide polymorphisms with atrial septal defect susceptibility in the Han Chinese population of Southwest China.

FLT4 HYDIN

1.54e-052137238581027
Pubmed

Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion.

FOXA2 PPARGC1B

1.54e-052137216459311
Pubmed

Identification of differentially expressed genes in mouse development using differential display and in situ hybridization.

CFC1 CFC1B

1.54e-052137211327798
Pubmed

Subtractive hybridization identifies chick-cripto, a novel EGF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis.

CFC1 CFC1B

1.54e-052137211024280
Pubmed

Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.

CFC1 CFC1B

1.54e-052137211062482
Pubmed

Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.

FOXA2 CFC1 CFC1B

2.11e-0514137317210915
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

CYLD GBF1 LAMA5 RNF213 PPA1 PDE12 DST UBXN7 RNF216 TOPORS

2.24e-054811371028190767
Pubmed

Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala.

PDE1C STARD8 RGS8 C1R PLXNA1

2.66e-0588137521491433
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

GBF1 DMXL1 SH3BP4 DST PRKAA2 TACC1 ADGRL2 SMCR8 PLXNA1 DOP1B

3.32e-055041371034432599
Pubmed

Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner.

FOXA2 CFC1 CFC1B

3.90e-0517137318697220
Pubmed

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.

ADGRB2 CPNE4 PLXNA1

3.90e-0517137331171447
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

PDE1C FLT4 GBF1 RET PTPDC1 CDC25B SRRM2 PID1 UNC80

4.61e-05420137928065597
Pubmed

Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis.

PKN1 CDC25B

4.61e-053137217332740
Pubmed

Rare Variants in LAMA5 Gene associated with FLT4 and FOXC2 Mutations in Primary Lymphedema May Contribute to Severity.

FLT4 LAMA5

4.61e-053137229908552
Pubmed

ALK, ROS1 and RET rearrangements in lung squamous cell carcinoma are very rare.

RET ROS1

4.61e-053137226973202
Pubmed

ALK, ROS1 and RET fusions in 1139 lung adenocarcinomas: a comprehensive study of common and fusion pattern-specific clinicopathologic, histologic and cytologic features.

RET ROS1

4.61e-053137224629636
Pubmed

Elevated MMP10/13 mediated barrier disruption and NF-κB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family knockout mice.

MMP10 MMP13

4.61e-053137234979166
Pubmed

Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase.

PDE1A PDE1C

4.61e-05313729003415
Pubmed

Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation.

PTPRJ PLCG1

4.61e-053137211259588
Pubmed

Molecular characterization of inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fusions and rare novel RET rearrangement.

RET ROS1

4.61e-053137225723109
Pubmed

Development of lung adenocarcinomas with exclusive dependence on oncogene fusions.

RET ROS1

4.61e-053137225855381
Pubmed

Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.

PDE1A PDE1C

4.61e-053137218335582
Pubmed

Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons.

PDE1A PDE1C

4.61e-05313727568196
Pubmed

AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival.

PPARGC1B PRKAA2

4.61e-053137226351140
Pubmed

Highly sensitive fusion detection using plasma cell-free RNA in non-small-cell lung cancers.

RET ROS1

4.61e-053137234310819
Pubmed

Clinical outcomes with pemetrexed-based systemic therapies in RET-rearranged lung cancers.

RET ROS1

4.61e-053137227056998
Pubmed

Potential Unreliability of Uncommon ALK, ROS1, and RET Genomic Breakpoints in Predicting the Efficacy of Targeted Therapy in NSCLC.

RET ROS1

4.61e-053137233248323
Pubmed

Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes.

PDE1A PDE1C

4.61e-053137217726023
Pubmed

AJUBA promotes the migration and invasion of esophageal squamous cell carcinoma cells through upregulation of MMP10 and MMP13 expression.

MMP10 MMP13

4.61e-053137227172796
Pubmed

Comprehensive analysis of ALK, ROS1 and RET rearrangements in locally advanced rectal cancer.

RET ROS1

4.61e-053137233168793
Pubmed

Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs.

CFC1 CFC1B

4.61e-053137216835440
Pubmed

Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt.

IRS1 PID1

4.61e-053137219079291
Pubmed

Up-regulation of matrix metalloproteinases in a mouse model of chemically induced colitis-associated cancer: the role of microRNAs.

MMP10 MMP13

4.61e-053137225742789
Pubmed

Clinicopathological characteristics and survival of ALK, ROS1 and RET rearrangements in non-adenocarcinoma non-small cell lung cancer patients.

RET ROS1

4.61e-053137227635639
Pubmed

Multiplexed transcriptome analysis to detect ALK, ROS1 and RET rearrangements in lung cancer.

RET ROS1

4.61e-053137228181564
Pubmed

Kinase gene fusions in defined subsets of melanoma.

RET ROS1

4.61e-053137227864876
Pubmed

Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.

FOXA2 CFC1 CFC1B

4.67e-0518137317936261
Pubmed

Tcf3: a transcriptional regulator of axis induction in the early embryo.

FOXA2 CFC1 CFC1B

4.67e-0518137314668413
Pubmed

Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development.

FOXA2 PLCG1 PJA1

6.49e-0520137311438667
Pubmed

Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions.

PPA1 FOXA2 MMP13

7.55e-0521137329659575
Pubmed

Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.

FOXA2 CFC1 CFC1B

7.55e-0521137316291790
Pubmed

A Large-scale genetic association study of esophageal adenocarcinoma risk.

CYP2C18 UGT1A6 INPPL1 IRS1 RET GHR PPARGC1B MMP10

8.03e-05351137820453000
Pubmed

Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo.

FOXA2 CFC1 CFC1B

8.72e-0522137318241853
Pubmed

Cripto in tumors and embryo development.

CFC1 CFC1B

9.19e-054137211825688
Pubmed

Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.

FES PLXNA1

9.19e-054137212093729
Pubmed

Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2.

PER2 PRKAA2

9.19e-054137217525164
Pubmed

Inhibiton of RET and JAK2 signals and upregulation of VEGFR3 phosphorylation in vitro by galectin-1 in trophoblast tumor cells BeWo.

FLT4 RET

9.19e-054137219900702
Pubmed

Detection of Gene Rearrangements in Circulating Tumor Cells: Examples of ALK-, ROS1-, RET-Rearrangements in Non-Small-Cell Lung Cancer and ERG-Rearrangements in Prostate Cancer.

RET ROS1

9.19e-054137228560674
Pubmed

Role of the EGF-CFC gene cripto in cell differentiation and embryo development.

CFC1 CFC1B

9.19e-054137211992720
Pubmed

PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin.

IRS1 PPARGC1B

9.19e-054137230770439
Pubmed

RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2.

RET PLCG1

9.19e-05413729047383
Pubmed

Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1.

CFC1 CFC1B

9.19e-05413729576836
Pubmed

Mini-review: toward understanding mechanisms of genetic neural tube defects in mice.

LAMA5 GRHL3

9.19e-054137210525207
Pubmed

Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse.

FOXA2 CFC1 CFC1B

1.14e-0424137318171685
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

FLT4 CILK1 RET KCNA6 PRKAA2 FES PKN1 MAP3K15

1.20e-04372137822939624
Pubmed

Overview of PDEs and their regulation.

PDE1A PDE1C PDE12

1.29e-0425137317307970
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CYLD RNF213 FAM53C ABCA8 PBRM1 RNH1 EPC1 CHPF2 ADGRL2 TOPORS SRRM2 UNC80 WDR62 ZNF646

1.38e-0411161371431753913
Pubmed

The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo.

FOXA2 CFC1 CFC1B

1.45e-0426137323651855
Pubmed

Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes.

MMP10 MMP13

1.53e-04513727669731
Pubmed

Recurrent CIC Gene Abnormalities in Angiosarcomas: A Molecular Study of 120 Cases With Concurrent Investigation of PLCG1, KDR, MYC, and FLT4 Gene Alterations.

FLT4 PLCG1

1.53e-045137226735859
Pubmed

A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation.

CFC1 CFC1B

1.53e-04513729053319
Pubmed

Immunohistochemical and transcriptional expression of matrix metalloproteinases in full-term human umbilical cord and human umbilical vein endothelial cells.

MMP10 MMP13

1.53e-045137220936527
Pubmed

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK).

IRS1 PLCG1

1.53e-04513729174053
Pubmed

RET, ROS1 and ALK fusions in lung cancer.

RET ROS1

1.53e-045137222327623
Pubmed

Role of NADPH oxidase-2 in lipopolysaccharide-induced matrix metalloproteinase expression and cell migration.

MMP10 MMP13

1.53e-045137219935767
Pubmed

Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb.

CFC1 CFC1B

1.53e-045137225224222
Pubmed

Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation.

PKN1 PLCG1

1.53e-045137215123640
Pubmed

Structure and function of hemidesmosomes: more than simple adhesion complexes.

LAMA5 DST

1.53e-045137210201522
Pubmed

Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.

GBF1 DEPTOR LPIN1 TACC1 CDC25B

1.58e-04128137525332235
Pubmed

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.

CAPN6 PBK RET ROS1 UPK3A

1.70e-04130137528705898
Pubmed

FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program.

FOXA2 MMP13

2.29e-046137222595668
Pubmed

A role of the cryptic gene in the correct establishment of the left-right axis.

CFC1 CFC1B

2.29e-046137210574770
Pubmed

A new chemical probe for quantitative proteomic profiling of fibroblast growth factor receptor and its inhibitors.

FLT4 RET

2.29e-046137224184958
Pubmed

Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.

CFC1 CFC1B

2.29e-046137212052855
Pubmed

Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway.

RET FOXA2

2.29e-04613728787761
Pubmed

Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux.

RET UPK3A

2.29e-046137219959718
Pubmed

Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance.

IRS1 PPARGC1B

2.29e-046137212565902
Pubmed

Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein.

MMP10 MMP13

2.29e-04613728144618
Pubmed

GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth.

CFC1 CFC1B

2.29e-046137217991893
Pubmed

New Targets in Non-Small Cell Lung Cancer.

RET ROS1

2.29e-046137227912827
Pubmed

Immunoglobulin VH gene expression in human aging.

EPC1 RNF216

2.29e-046137210527689
Pubmed

NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.

LPIN1 PPARGC1B

2.29e-046137222586274
Pubmed

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1.

IRS1 GHR

2.29e-04613727782332
Pubmed

The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.

ADGRB2 ADGRL2

2.29e-046137210964907
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

CYLD DEPTOR INPPL1 SNX16 FAM53C MTFR1L LPIN1 PTPDC1 C5orf34 RNF216 PJA1 AP4B1 CDC25B

2.44e-0410381371326673895
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DEPTOR CILK1 RNF213 AHDC1 ITPKB SH3BP4 EVA1C PTPDC1 PPARGC1B PTPRJ PRKAA2 NGEF ANKRD11 PKN1 PLCG1 ZNF512

2.65e-0414891371628611215
Pubmed

New targetable oncogenes in non-small-cell lung cancer.

RET ROS1

3.19e-047137223401445
Pubmed

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.

RET ROS1

3.19e-04713727990960
Pubmed

Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.

MMP10 MMP13

3.19e-047137211113146
CoexpressionGSE26669_CTRL_VS_COSTIM_BLOCK_MLR_CD8_TCELL_DN

ITGAX ADCY7 PITPNM1 C5orf34 FEZ2 PKN1 PLCG1 ZNF512

9.67e-062001358M4667
CoexpressionGSE360_CTRL_VS_B_MALAYI_LOW_DOSE_DC_DN

CYLD PDE1A ADGRB2 CILK1 IRS1 RET ADGRL2 DOP1B

9.67e-062001358M5153
ToppCellCOVID-19-COVID-19_Severe-Myeloid-cDC|COVID-19_Severe / Disease, condition lineage and cell class

DEPTOR PPA1 ITGAX SH3BP4 DST RNH1 FES UPK3A PID1

1.32e-082001389e7b808d8ed65343a4345fafb03015fe4f7ce302f
ToppCellCOVID-19-COVID-19_Mild-Myeloid-cDC|COVID-19_Mild / Disease, condition lineage and cell class

DEPTOR PPA1 ITGAX SH3BP4 DST RNH1 FES UPK3A PID1

1.32e-082001389b8f52e65813d331c49cdd5f354fdfec6fc8c339e
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE1A ADGRB2 EXTL1 DNAAF11 PEX5L NGEF NEURL1B ADGRL2

9.98e-08181138858f76bb9ea1518c2b629a0256a3f6595a9278152
ToppCellCOVID_vent-Myeloid-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

DEPTOR PPA1 ITGAX SH3BP4 DST RNH1 FES UPK3A

1.23e-07186138863a5cdd3f60681762a218be32db84be8f29b88fd
ToppCellCOVID_vent-Myeloid-Dendritic-cDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

DEPTOR PPA1 ITGAX SH3BP4 DST RNH1 FES UPK3A

1.23e-07186138839457a7b43537f2c3e221f9375c95d4515424d7d
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-conventional_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DEPTOR PPA1 ITGAX DST RNH1 FES UPK3A PID1

1.45e-0719013884b25d49f033bbd326b47cf5602af3f0262cfc367
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-conventional_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DEPTOR PPA1 ITGAX DST RNH1 FES UPK3A PID1

1.57e-0719213888e606eae3e5b07a856d3c2a74186d486da96309c
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.70e-0719413886af2971d83f5ad6aed16d0ceb8bfc52f3947bc10
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.70e-0719413885c60670ec24470225fabaa6071fdb4ef6e579840
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_9|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.77e-071951388dd28c63b53f2a97e3fac127294a465870dc371b3
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_9|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.77e-071951388d6ff38535898f90be6719cd5152291f2f4f8a746
ToppCellPBMC-Control-Myeloid-cDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.84e-071961388e1f763fa9c11bf5f4d80e79f70f9485724ac23fe
ToppCellControl-Myeloid-cDC|Control / Disease group, lineage and cell class

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.84e-07196138885d92bc226cc28384c30991cc4ebb02ec2e3ec99
ToppCellPBMC-Control-Myeloid-cDC-cDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.84e-071961388553c22c7d48f3b4f6f2b2f10d6e668c5ebb09e8c
ToppCellPBMC-Control-Myeloid-cDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.84e-071961388d376168e15ec1cf618723259966c76be3698b9b0
ToppCellPBMC-Control-Myeloid-cDC-cDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.84e-0719613884a9095ba3f6709f88f32bf09184553f4bd211f43
ToppCellBasal_cells|World / lung cells shred on cell class, cell subclass, sample id

UGT1A6 LAMA5 DST CYP4X1 WNT10A NHS MMP10 MMP13

1.91e-07197138824360b660000bdfb999d58fbf4e29585a97e1785
ToppCellPBMC-Severe-Myeloid-cDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.91e-07197138822e4ffb5de483eaf78f14badf3d08db898e3b3dd
ToppCellPBMC-Severe-Myeloid-cDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.91e-071971388346974c6c5809a3fe88cbf067e2d64c340310a31
ToppCellCOVID-19_Mild-Myeloid-cDC|COVID-19_Mild / Disease group, lineage and cell class

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.91e-0719713882901904b8a791fac2668fd737eff7e7144378db4
ToppCellPBMC-Severe-Myeloid-cDC-cDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.91e-0719713881ae45c1ec3b3f88e0c1f99de58c58b1ec1b968ee
ToppCellCOVID-19_Severe-Myeloid-cDC|COVID-19_Severe / Disease group, lineage and cell class

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.91e-071971388843b0f1cc26864ee635df7938c77552ee06fe00b
ToppCellPBMC-Severe-Myeloid-cDC-cDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.91e-071971388f78f44dcd7855c96f148678c1f416075aef71b4e
ToppCellHealthy-cDC|World / disease group, cell group and cell class

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

1.99e-0719813888976f8d26cb7ff79f74def138c4bbbb0bc2eaf00
ToppCellControl-Control-Myeloid-cDC|Control / Disease, condition lineage and cell class

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

2.15e-0720013881375d199320feb85ba06e74b10df6521e790addf
ToppCellBasal_cells-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

PDE1A ABCA13 AHDC1 GHR PRKAA2 NHS MMP10

7.83e-071631387679e25e5548d157d49a73057a3b5617dccda260f
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C NYAP2 GHR C1R CPNE4 PID1

1.08e-0617113879e00c8191ca9d52151a49baf39f8581cb176fb76
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C NYAP2 GHR C1R CPNE4 PID1

1.12e-06172138792e76cbf4807704790f42cf2507e92f85cd3bc92
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C NYAP2 GHR C1R CPNE4 PID1

1.17e-061731387ee972d9cc68755926512fd3bbe1267098c67cd94
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C NYAP2 GHR C1R CPNE4 PID1

1.36e-0617713877e799333307448c6a94d1f33dbc59c543336f45e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C NYAP2 NGEF C1R CPNE4 PID1

1.47e-061791387b35a7f8115c997c390201da01d7cb10b10769aec
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C NYAP2 DEPTOR GHR C1R CPNE4

1.52e-0618013878923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DDAH2 RET ITGAX SH3BP4 DST UPK3A PID1

1.58e-061811387c8286a7ac8e3cc5aa7e92b043a08435294ea686f
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A

2.10e-061891387c81b38cda4525254fe4fa137a4c9bc9abe0363bb
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A

2.10e-061891387807922b5ea0faddd3abfa9ec1b53f3f2b00e61bf
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP15 ABCA8 GHR ATRNL1 C1R NEURL1B PID1

2.18e-0619013872306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP15 ABCA8 GHR ATRNL1 C1R NEURL1B PID1

2.18e-0619013871f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DEPTOR ITGAX SH3BP4 DST FES UPK3A PID1

2.34e-061921387e24a8856ef01ccf69a5e968bd409f9b84befa91e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP15 ABCA8 GHR ATRNL1 C1R NEURL1B PID1

2.59e-061951387d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell(010)_cDC|World / immune cells in Peripheral Blood (logTPM normalization)

DEPTOR ITGAX SH3BP4 DST FES UPK3A PID1

2.59e-0619513874aabb3f5ce70100e4d98d7fa9f8d12e84fb9fe3d
ToppCellCOVID-19_Severe-cDC|COVID-19_Severe / disease group, cell group and cell class

PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

2.59e-0619513876419090b19de7b5d5140eaecf231860273da2c0d
ToppCellBasal_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

UGT1A6 LAMA5 IRS1 DST CYP4X1 MMP10 MMP13

2.68e-0619613873b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCellhealthy_donor-Myeloid-Dendritic|healthy_donor / Disease condition, Lineage, Cell class and subclass

DEPTOR ITGAX SH3BP4 DST FES UPK3A PID1

2.68e-061961387ea590b8ea3d13ff93cb5863a44936b0cfdf3b868
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A

2.68e-0619613870bac14c018487ca67e7f9255b5f186e7ae665774
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A

2.68e-06196138733345338c825484960daa1ed82a19df38ccfc5c0
ToppCellhealthy_donor-Myeloid-Dendritic-cDC|healthy_donor / Disease condition, Lineage, Cell class and subclass

DEPTOR ITGAX SH3BP4 DST FES UPK3A PID1

2.68e-061961387aac79fc45cab4a16e2fa02652ece0999591261a5
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE1C FAM110D LAMA5 RYR3 EVA1C TACC1 ADGRL2

2.77e-06197138787eda06344498dc66cac292cf89746dc90b5cf67
ToppCellPBMC-Mild-Myeloid-cDC-cDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A

2.77e-0619713879162ede5572326c00ede0769fe7f4e0dd14d2340
ToppCellnormal-na-Myeloid-conventional_dendritic_cell-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

DEPTOR PPA1 DST RNH1 FES UPK3A PID1

2.77e-06197138717c6d2a7baef6393c3e2d3e65cc924df22049eb0
ToppCellnormal-na-Myeloid-conventional_dendritic_cell|normal / PBMC cell types (v2) per disease, treatment status, and sex

DEPTOR PPA1 DST RNH1 FES UPK3A PID1

2.77e-0619713879a0bcb055b1a5fd5439e4a0bf1742f009331df47
ToppCellPBMC-Mild-Myeloid-cDC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A

2.77e-061971387021c9c48375259b808e1f36a029c4fe6971c00eb
ToppCellPBMC-Mild-Myeloid-cDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A

2.77e-06197138718df0e447bcea2a405a357563f87bacc57466227
ToppCellPBMC-Mild-Myeloid-cDC-cDC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A

2.77e-0619713870460b6907743a354792b5bc40bff01aac7c41684
ToppCellHealthy/Control-cDC|World / Disease group and Cell class

DEPTOR PPA1 ITGAX SH3BP4 DST UPK3A PID1

2.77e-0619713874497d4073f4d3e74de907325fba9eb4af5766bf4
ToppCellHealthy_donor-cDC|World / disease group, cell group and cell class (v2)

DEPTOR PPA1 ITGAX SH3BP4 DST UPK3A PID1

2.77e-061971387a545fe3a80cd721bf01115bbb645753840ec9f40
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DEPTOR ITGAX SH3BP4 DST FES UPK3A PID1

2.86e-061981387898ef4f02443780f9b1fc08b73a165fda0ca5cde
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DEPTOR ITGAX SH3BP4 DST FES UPK3A PID1

2.86e-061981387d0371e2ca9e25727b35985940f6228f9d8e49727
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DEPTOR ITGAX SH3BP4 DST FES UPK3A PID1

2.86e-06198138708ad0bece508bb4f9cc126d94839b5c89ce21ba8
ToppCellsystemic_lupus_erythematosus-managed-Myeloid-conventional_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DEPTOR PPA1 DST RNH1 FES UPK3A PID1

2.86e-061981387b0e090000d1cdee4628f4ab252f6b444658f80f5
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-conventional_dendritic_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DEPTOR ITGAX SH3BP4 DST FES UPK3A PID1

2.86e-06198138742be18aef4f656a86c61630b061826a858c496fd
ToppCellHealthy-cDC|Healthy / disease group, cell group and cell class

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A

2.86e-0619813874cf874333b9fd6cd22ee647cd12c032fc6d05740
ToppCellsystemic_lupus_erythematosus-managed-Myeloid-conventional_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DEPTOR PPA1 DST RNH1 FES UPK3A PID1

2.86e-06198138799f98e240d81cfe5b485da2598f8392d7cbd9013
ToppCellCOVID-19_Severe-cDC|World / disease group, cell group and cell class

PPA1 ITGAX SH3BP4 DST FES UPK3A PID1

2.86e-061981387c452334249f047265ae89dcabe7de446d968cae6
ToppCellcontrol-cDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DEPTOR ITGAX SH3BP4 DST FES UPK3A PID1

2.96e-06199138731825ba336603fe940dea6022e18ec25af110f4c
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PDE1C FLT4 STARD8 LAMA5 FUT1 NEURL1B ADGRL2

2.96e-06199138714a7c4cf4bb3d43fd32ec9cc74f6625b225ffaa1
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E-|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1A PDE1C NYAP2 NGEF C1R CPNE4 PID1

3.06e-0620013871a3d29a580d1b405a74869a1da3e818c581fc559
ToppCellcontrol-cDC|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DEPTOR ITGAX SH3BP4 DST FES UPK3A PID1

3.06e-0620013874a6d17a4225be38537d3dd8a39512051f597f4e0
ToppCellMS-IIF-Myeloid-cDC|IIF / Disease, condition lineage and cell class

DEPTOR ITGAX DST RNH1 FES UPK3A PID1

3.06e-062001387620a82805619d113182d59740670c9f9b93ee924
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E---L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1A PDE1C NYAP2 NGEF C1R CPNE4 PID1

3.06e-0620013876f9ed8fe9cda91185c3a1a675353e11b8fec6ef1
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E--|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1A PDE1C NYAP2 NGEF C1R CPNE4 PID1

3.06e-06200138786705dfc05b3e1576543b93883c88fb55b742855
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1A PDE1C NYAP2 NGEF C1R CPNE4 PID1

3.06e-062001387db194b4f524fd008b3c5b4b6014b436190a1b87a
ToppCellNeuronal-Excitatory-eB(RORB)|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1A PDE1C NYAP2 GHR C1R CPNE4 PID1

3.06e-06200138751265e30f1138fd79733001d0db759f3dab0aaeb
ToppCellmild-cDC|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DEPTOR PPA1 ITGAX SH3BP4 DST FES UPK3A

3.06e-062001387d6409ee5b9067be3dd2f852825e09151b5b22d7c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP15 RET ABCA8 ATRNL1 NEURL1B PID1

6.12e-061451386051d964ff6bdc12ba3f0459d3e6ab16fa9507b0b
ToppCellFetal_29-31_weeks-Epithelial-basal_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ABCA13 LAMA5 EVA1C PER2 MMP10 MMP13

1.42e-0516813866521bead9789d626b86cbd08692c621c5a5aef33
ToppCellFetal_29-31_weeks-Epithelial-basal_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ABCA13 LAMA5 EVA1C PER2 MMP10 MMP13

1.47e-051691386c3ee781735a9288ce1822b230d39bb91c1415589
ToppCellTCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium|TCGA-Endometrium / Sample_Type by Project: Shred V9

PCDHGA2 ABCA8 RYR3 GHR TACC1 PID1

1.52e-051701386cdc19013da7c41d1ed8400a6a643e4c684ff9912
ToppCellTCGA-Endometrium-Solid_Tissue_Normal|TCGA-Endometrium / Sample_Type by Project: Shred V9

PCDHGA2 ABCA8 RYR3 GHR TACC1 PID1

1.52e-0517013860bde0a40440c7fdf7ba89cac8831d4014e7a4807
ToppCellTCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue|TCGA-Endometrium / Sample_Type by Project: Shred V9

PCDHGA2 ABCA8 RYR3 GHR TACC1 PID1

1.52e-051701386516b38c4ecf6b0b04c5d4f80c510dcc00b328c6f
ToppCellP07-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DEPTOR EXTL1 KCNA6 SHPK CPNE4 UNC80

1.62e-0517213868d6a2a0d5f63b09a5a304a77e600a647f87e9de4
ToppCellmild_COVID-19_(asymptomatic)-cDC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

DDAH2 DEPTOR PPA1 SH3BP4 DST UPK3A

1.67e-05173138671dc0051c87b84e3cf13cde8858166f2a474b5dc
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C NYAP2 GHR CPNE4 PID1

1.73e-0517413862947e5906b172d149412fa4e77476fce4ea695d2
ToppCellwk_15-18-Mesenchymal-Chondrocyte-Resting_chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

STK26 CAPN6 PTPDC1 SCUBE3 CPNE4 SLC38A3

1.90e-051771386b01d7a6a78169962123ddfb0bb588f51d138ad02
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C NYAP2 C1R CPNE4 PID1

1.97e-051781386a48739a588f361b4bc69405d7e256c11f61cf43c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C NYAP2 DEPTOR GHR CPNE4

2.03e-05179138653e700494d251ec5649b2dea5fc7d5aeeeed572b
ToppCellmild_COVID-19_(asymptomatic)-cDC|World / disease group, cell group and cell class (v2)

DDAH2 PPA1 SH3BP4 DST UPK3A PID1

2.09e-05180138668d1c867734fb2977b01ac686b20bf602f9a6b72
ToppCellMesenchymal_cells-Chondrocytes|Mesenchymal_cells / Lineage and Cell class

STK26 EXTL1 PPA1 KCNA6 NGEF SLC38A3

2.09e-0518013866e399368430ef3afa9ce1ef0ed90f614ccef9987
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-DC-cDC2|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SH3BP4 FSIP2 RGS8 ATRNL1 UPK3A PID1

2.23e-0518213861d37c486173cc4629842893ddd5033987c04086f
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-DC-cDC2-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SH3BP4 FSIP2 RGS8 ATRNL1 UPK3A PID1

2.23e-051821386aef67bdc6937b315522d39959e26c9b0acf7ab52
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-DC|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SH3BP4 FSIP2 RGS8 ATRNL1 UPK3A PID1

2.23e-051821386087c9f88daf08f5d688b728c2386f91f210d2255
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-DC2|bone_marrow / Manually curated celltypes from each tissue

PPA1 ITGAX SH3BP4 RNH1 UPK3A PID1

2.30e-051831386f482e4fe011fa450a475034b1e25587233855bdb
ToppCell(7)_Epithelial-H_(AT1)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

EPN3 UGT1A6 LAMA5 CYP4X1 GRHL3 MMP13

2.37e-0518413861f76b37c265b519171b767a52d48f31f0cdc4a3c
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1C ABCA13 RYR3 ROS1 HYDIN UNC80

2.37e-0518413862cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1C ABCA13 RYR3 ROS1 HYDIN UNC80

2.37e-051841386ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1C ABCA13 RYR3 ROS1 HYDIN UNC80

2.37e-0518413862b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C NYAP2 NGEF CPNE4 PID1

2.37e-0518413869cc5c588f7c6631b3fb8a522214a09ca32947e72
ToppCell15-Trachea-Epithelial-Multiciliated_precursor|Trachea / Age, Tissue, Lineage and Cell class

LRWD1 ADGRB2 PITPNM1 FIBCD1 NEURL1B WDR62

2.44e-0518513869a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RET ABCA8 CYP4X1 WNT10A C1R PID1

2.44e-051851386e1fbec55b71f604189eb2431768fadbaa0453a83
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RET ABCA8 CYP4X1 WNT10A C1R PID1

2.44e-0518513869d933cd5ebc8368fd37aa83113d2dfa6938ff72d
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-chondrocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CAPN6 EXTL1 FOXA2 NGEF SCUBE3 SLC38A3

2.52e-05186138680a0a42ca8585cdb1dda57a18c254316a126ee64
ComputationalMetal / Ca ion binding.

PPA1 RET ITGAX RYR3 C1R MMP10 MMP13

4.44e-05133777MODULE_324
Diseasecoronary artery disease

PDE1A PDE1C NYAP2 ARHGAP15 EFCAB13 RNF213 LRRC40 AHDC1 ABCA8 DMXL1 PTPRJ FES C1R PLCG1 ADGRL2 MMP13 PID1

3.68e-05119413617EFO_0001645
DiseaseRENAL ADYSPLASIA

RET UPK3A

6.31e-0531362C1619700
Diseasedouble outlet right ventricle (implicated_via_orthology)

CFC1 CFC1B

6.31e-0531362DOID:6406 (implicated_via_orthology)
Diseasedextro-looped transposition of the great arteries (implicated_via_orthology)

CFC1 CFC1B

1.26e-0441362DOID:0060770 (implicated_via_orthology)
Diseaseright atrial isomerism (implicated_via_orthology)

CFC1 CFC1B

1.26e-0441362DOID:0060856 (implicated_via_orthology)
DiseaseThymoma

CYLD PBRM1

2.09e-0451362C0040100
Diseasedehydroepiandrosterone sulphate measurement

PUDP ABCA13 MCM9 NEURL1B

2.80e-04681364EFO_0007001
DiseaseThymic Carcinoma

CYLD PBRM1

4.36e-0471362C0205969
DiseaseUnilateral agenesis of kidney

RET UPK3A

5.80e-0481362C0266294
Diseaseurate measurement, bone density

CRACR2A ARHGAP15 UGT1A6 LAMA5 LINC00615 ABCA8 ITPKB FSIP2 ANKRD11 SLC38A3

6.14e-0461913610EFO_0003923, EFO_0004531
DiseaseAdenocarcinoma of large intestine

RET PKN1 ROS1 MAP3K15

1.03e-03961364C1319315
Diseasecerebral cavernous malformation (implicated_via_orthology)

STK26 RNF213

1.13e-03111362DOID:0060669 (implicated_via_orthology)
Diseaseinterstitial collagenase measurement

MMP10 MMP13

1.13e-03111362EFO_0008193
Diseasepregnenetriol sulfate measurement

PUDP UGT1A6

1.13e-03111362EFO_0800586
DiseaseGastric Adenocarcinoma

STK26 PRKAA2 ROS1

1.18e-03451363C0278701
Diseasetype 2 diabetes mellitus (is_implicated_in)

INPPL1 IRS1 FOXA2 GHR PRKAA2

1.20e-031711365DOID:9352 (is_implicated_in)
Diseasevisceral heterotaxy (is_implicated_in)

CFC1 CFC1B

1.35e-03121362DOID:0050545 (is_implicated_in)
DiseaseN-acetylputrescine measurement

HDAC10 SLC38A3

1.35e-03121362EFO_0800127
Diseasepregnenetriol disulfate measurement

PUDP UGT1A6

1.59e-03131362EFO_0800587
DiseaseMetastatic melanoma

FLT4 PKN1 MAP3K15

2.00e-03541363C0278883
Diseasematrix metalloproteinase 1 measurement

MMP10 MMP13

2.13e-03151362EFO_0010588
DiseaseBMI-adjusted adiponectin measurement

NYAP2 PBRM1

2.13e-03151362EFO_0007737
Diseasehair colour measurement

NYAP2 SNX16 NGEF FES ANKRD11 TACC1 ASXL2 PLXNA1 MVD

2.25e-036151369EFO_0007822
Diseaseneurofilament light chain measurement

DMXL1 SMCR8 SLC38A3

2.34e-03571363EFO_0009178
Diseasegliosarcoma

CYP2C18 TACC1

2.43e-03161362C0206726
Diseaselow density lipoprotein cholesterol measurement, body fat percentage

UGT1A6 EFCAB13

2.74e-03171362EFO_0004611, EFO_0007800
DiseaseLipidemias

IRS1 PPARGC1B

2.74e-03171362C1706412
DiseaseHyperlipidemia

IRS1 PPARGC1B

2.74e-03171362C0020473
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

PALB2 PTPRJ

3.43e-03191362C1333991
Diseasereasoning

PDE1C PID1

3.43e-03191362EFO_0004350
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

PALB2 PTPRJ

3.43e-03191362C2936783
DiseaseParkinson disease

GBF1 LZTS3 ITPKB NGEF PJA1 ZNF646

3.82e-033211366MONDO_0005180
Diseasesystemic lupus erythematosus

NYAP2 ARHGAP15 TCP11 SLC22A11 GPR78 ITGAX GHR ADO SCUBE3 GRHL3

4.00e-0379913610MONDO_0007915
DiseaseMalignant neoplasm of breast

STARD8 EFCAB13 PPA1 PALB2 PPARGC1B C5orf34 PBRM1 PER2 PRKAA2 NHS MMP10 ZNF646

4.14e-03107413612C0006142
Diseaseosteoporosis (biomarker_via_orthology)

IRS1 GHR

4.59e-03221362DOID:11476 (biomarker_via_orthology)
Diseasetooth agenesis

ARHGAP15 WNT10A

4.59e-03221362EFO_0005410

Protein segments in the cluster

PeptideGeneStartEntry
RSPFKESCDPSLGLA

TACC1

71

O75410
SLRLATAFDPAPSAC

ADGRB2

26

O60241
LDASKPLPVFRCEDL

EPC1

11

Q9H2F5
FSNCKSLPEAPLDVA

ANKRD11

2066

Q6UB99
LEPVRPKEASSSACD

ADO

226

Q96SZ5
PKEASSSACDLPREV

ADO

231

Q96SZ5
DSPKARCPLDALNTT

PRKAA2

376

P54646
KECPFPDALTFITLD

BCDIN3D

121

Q7Z5W3
PSKEARACRTPESFL

EPN3

486

Q9H201
EASKTALCPERFVPL

ASB15

26

Q8WXK1
AERCDPELPKTSSFA

AP4B1

581

Q9Y6B7
SDKPDIISEALACFP

ABCA13

1806

Q86UQ4
IFPLPERFCEALDSK

ADGRL2

461

O95490
ALCKEESSPSAPDRL

CRACR2A

531

Q9BSW2
LQTPDRCDPKDFLAS

CFC1B

151

P0CG36
LTPAASDCRAAETFP

AHDC1

931

Q5TGY3
LAASSKTRALCEPLP

ADCY7

706

P51828
EFCGKQRPPDLDTSS

C1R

266

P00736
SKDCSPSSPLKLDAR

DMXL1

1901

Q9Y485
LQTPDRCDPKDFLAS

CFC1

151

P0CG37
PEDRFCLSSPTEALK

ASXL2

1146

Q76L83
FTTCSLPEDLPFKLE

PCDHGA2

381

Q9Y5H1
LRCSSEKIAPPASDF

ITGAX

996

P20702
DDVPLSLSPSKRACA

LRWD1

236

Q9UFC0
PAKCDPALSFDAIST

MMP10

286

P09238
TPDRFPELSKVASLC

OR9K2

286

Q8NGE7
KSLEPGRKSFCTDPA

PTPRJ

706

Q12913
LSFKDFLSCRPTEIP

PBRM1

1236

Q86U86
FPSLPAACLAELLDS

KLHL33

111

A6NCF5
LDQCSEPLVRPSAFK

LZTS3

151

O60299
EESPPSASACLKDVF

MAGEB10

36

Q96LZ2
LSLAPKFCRSDARPV

HOXD1

21

Q9GZZ0
DPDIFLACAKRFSPP

PUDP

151

Q08623
NSSELKPESRDDPFC

DST

3211

Q03001
SACKFLDTALSFPPD

DOP1B

2151

Q9Y3R5
DAPSCAVLLPASRFL

DCAF4L1

151

Q3SXM0
TSARLPLTFCDTFPK

FSIP2

2181

Q5CZC0
LSLPLCEDTAFLPSK

PID1

6

Q7Z2X4
KCEFPANVPALRSSD

PER2

606

O15055
PPKESALCLFTLRAI

PLXNA1

351

Q9UIW2
PDKCDPSLSLDAITS

MMP13

281

P45452
RCVPSEPKLSLSFAL

PDE12

41

Q6L8Q7
AELGLPFSPLCDRKS

PDE1A

396

P54750
AELGLPFSPLCDRKS

PDE1C

406

Q14123
PLLSPSIDDFLCETK

PEX5L

76

Q8IYB4
PLLKRSHSSDFPCSD

LPIN1

851

Q14693
SRDGDPLPSSLSCKV

MVD

96

P53602
RDAESFLLKSPIAPC

CDC25B

461

P30305
NLPLKPCARASFETL

MTFR1L

31

Q9H019
RSPLDCGSSPKAQFL

PTPDC1

546

A2A3K4
ADACDAKDPTDPFRL

LAMA5

306

O15230
CATPTVPDLDFAKAS

NYAP2

296

Q9P242
KSSAPKRSIPLESCF

IRS1

56

P35568
SAFASCSLRLPPEPE

GPR78

151

Q96P69
PPSADDNLKTRAECL

NPIPB11

321

E5RHQ5
HPCAKESESLRSPVF

PALB2

1076

Q86YC2
KSTPCPETLDVRLGF

PLA2G4E

321

Q3MJ16
CSSKAERLPPFDCLS

EVA1C

201

P58658
PVCKAAASAPSSLLD

HDAC10

386

Q969S8
FICETDKSLLPATPE

HYDIN

1096

Q4G0P3
LPLKRTCSPFTEEFE

GRHL3

486

Q8TE85
FELLVRFSACPSKPA

KCNA6

276

P17658
ATALPLPDKEFLSSC

GHR

611

P10912
SDRDALSKPDPCVIL

CPNE4

36

Q96A23
RDLSKPLTFPDGCTL

CYP4X1

386

Q8N118
PSSQETHDSPFCLRK

DEPTOR

236

Q8TB45
ILRAKCPPKTAASDD

ATRNL1

651

Q5VV63
LRTLPPLALFTSKEC

CSAD

176

Q9Y600
NKPCLFTPESRLETL

DNAAF11

251

Q86X45
ALAKERSFPECNALP

EFCAB13

516

Q8IY85
TLSESPFKCDPDAAR

PPA1

246

Q15181
PRCPDLTDSFARLES

FIBCD1

96

Q8N539
CDFEKPESPRAASSS

GBF1

1766

Q92538
LRKTNASPCDPTFIL

CYP2C18

156

P33260
RKFPQPTLVCASDRD

CCDC168

6691

Q8NDH2
LKSCRPDSRFASLQP

CYLD

536

Q9NQC7
TLPDDAAADCLFLRP

DDAH2

211

O95865
IKDSRLFCDPTFLPE

CAPN6

21

Q9Y6Q1
QLSPCGSEFLFEKSP

C5orf34

26

Q96MH7
ELKCTRFSISLPLPD

FAM53C

16

Q9NYF3
SAKEPRSVLDLFCVP

SLC22A11

326

Q9NSA0
ALTCPSRARFLPESE

SCUBE3

426

Q8IX30
EKLSLCFRPSDPGAE

FEZ2

56

Q9UHY8
RFLPEFPSCSLLKEL

LRRC40

256

Q9H9A6
EAAALFSRECRPSPA

MLNR

226

O43193
SCRETLPPDLKAKFL

FES

591

P07332
LSFNDCFLKVPRSPD

FOXA2

211

Q9Y261
LSCFEPDPHKRATTA

MAP3K15

886

Q6ZN16
ARLANFCFTPPSESK

MCM9

1056

Q9NXL9
DLRDPFLKLSGFPCS

FUT1

156

P19526
SCSDFTAILPDKPNR

RGS8

26

P57771
EPARSTPKILALCFA

SLC38A3

461

Q99624
SCFESSPDPELKSRT

SRRM2

871

Q9UQ35
LPLTFFCRAELDSEP

SH3BP4

781

Q9P0V3
QDFSPERPKADSLGC

NHS

736

Q6T4R5
IDACLNKDPSFRPTA

STK26

251

Q9P289
DPDKPFLRKACSPSN

ITPKB

551

P27987
LDPKCRGLPFSSFLI

NGEF

396

Q8N5V2
LPKDSSCPSRNLELF

ARHGAP15

191

Q53QZ3
RSCDAGAPPKDSTLL

PPARGC1B

741

Q86YN6
SRKPAFTEASCPLSR

INPPL1

916

O15357
FTEASCPLSRLFEEP

INPPL1

921

O15357
SAPSVFPSCKRLTLE

SETMAR

326

Q53H47
RCSSEFLASLPQPKS

SHPK

131

Q9UHJ6
AKLTCRISAFPDPFI

SPEGNB

71

A0A087WV53
PSCSFPALLDSDVKR

RNF216

606

Q9NWF9
PALLDSDVKRFSCPN

RNF216

611

Q9NWF9
LCSPLRKSPLTLEDF

PKN1

601

Q16512
LCPTCSLPLSEKERF

FAM110D

151

Q8TAY7
PKALRTLADEAPTCV

EXTL1

571

Q92935
KPGTFPRSLSIESLC

STARD8

226

Q92502
STCPSEALIPDDFKA

SMCR8

521

Q8TEV9
KDPFFRISPRSSDVC

ABCA8

1231

O94911
LCRFESVLDLKPSEP

CILK1

446

Q9UPZ9
EPGLVQKFSLRDCSP

CHPF2

721

Q9P2E5
SQDARPLAPAACISK

LINC00615

51

Q96LM1
CASRLEPLLAPKFQA

PITPNM1

736

O00562
STDFLPVDCPVRSKL

RNF213

606

Q63HN8
ECKILSPPDISRFAT

RNF213

4406

Q63HN8
LKEQLSATPPDFSCA

TCP11

96

Q8WWU5
SATPPDFSCALELLK

TCP11

101

Q8WWU5
PRPLCKSSLIAEFNS

UNC80

2886

Q8N2C7
PNDSRLKCLLDPAES

RYR3

4006

Q15413
PFCLSPISAALAESR

TBC1D16

236

Q8TBP0
AKRDAFSPCAEKSPE

FLT4

941

P35916
SLSADRKVACAPRPD

NEURL1B

291

A8MQ27
SLCPKEFDSLPALRS

ZNF646

851

O15015
KAVAFDLIPCSDLPS

UPK3A

101

O75631
PFDKSSLRGLEPCAI

PLCG1

1076

P19174
AASCEPLASVLRAKP

RNH1

156

P13489
LPRIPFADVKSFACE

ROS1

491

P08922
LFSVCTNEDPKDRPS

PBK

296

Q96KB5
NTSFPACSSLKPREL

RET

151

P07949
ACSSLKPRELCFPET

RET

156

P07949
SKDSLDPDPRCLLTN

WDR62

816

O43379
DASPDSKCPICLDRF

TOPORS

96

Q9NS56
PPKKCARSESLIDAS

UBXN7

271

O94888
DLPSRCASKDLSPEK

ZNF420

46

Q8TAQ5
KSPDFCEREPRLDSA

WNT10A

341

Q9GZT5
ESKFDALFTDPALPC

UGT1A6

141

P19224
ESRADNKPCLSFSEP

SNX16

311

P57768
KLDPVPAARCSASRA

PJA1

181

Q8NG27
CEPVSDFPASFRKST

ZNF512

61

Q96ME7
LNLPKTCDISFSDPD

UBE2M

41

P61081