Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZBTB7A ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 WIZ ZNF423 ZNF451 ZNF641 FOXB2 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 ZNF510 ZNF468 ZKSCAN5 ZBTB14 ZNF404 ZNF697	9.40e-13	1412	61	24	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZBTB7A ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 WIZ ZNF423 ZNF641 FOXB2 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 ZNF510 ZNF468 ZKSCAN5 ZBTB14 ZNF404 ZNF697	1.56e-11	1459	61	23	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZBTB7A ZNF263 ZNF845 ZNF320 ZNF394 WIZ ZNF423 FOXB2 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 ZNF468 ZKSCAN5 ZBTB14 ZNF697	2.62e-09	1244	61	19	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZBTB7A ZNF263 ZNF845 ZNF320 ZNF394 WIZ ZNF423 FOXB2 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 ZNF468 ZKSCAN5 ZBTB14 ZNF697	3.73e-09	1271	61	19	GO:0000987
Domain	Znf_C2H2	ZBTB7A ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 WIZ ZNF592 ZNF423 ZNF451 ZNF641 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 TUT1 ZNF510 ZNF468 ZKSCAN5 ZBTB14 ZNF404 ZNF697	6.27e-19	805	60	25	IPR007087
Domain	ZnF_C2H2	ZBTB7A ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 WIZ ZNF592 ZNF423 ZNF451 ZNF641 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 TUT1 ZNF510 ZNF468 ZKSCAN5 ZBTB14 ZNF404 ZNF697	6.85e-19	808	60	25	SM00355
Domain	ZINC_FINGER_C2H2_2	ZBTB7A ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 WIZ ZNF592 ZNF423 ZNF451 ZNF641 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 ZNF510 ZNF468 ZKSCAN5 ZBTB14 ZNF404 ZNF697	4.20e-18	775	60	24	PS50157
Domain	ZINC_FINGER_C2H2_1	ZBTB7A ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 WIZ ZNF592 ZNF423 ZNF451 ZNF641 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 ZNF510 ZNF468 ZKSCAN5 ZBTB14 ZNF404 ZNF697	4.45e-18	777	60	24	PS00028
Domain	zf-C2H2	ZBTB7A ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 ZNF592 ZNF423 ZNF451 ZNF641 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 ZNF510 ZNF468 ZKSCAN5 ZBTB14 ZNF404 ZNF697	5.61e-18	693	60	23	PF00096
Domain	Znf_C2H2-like	ZBTB7A ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 WIZ ZNF592 ZNF423 ZNF451 ZNF641 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 ZNF510 ZNF468 ZKSCAN5 ZBTB14 ZNF404 ZNF697	7.73e-18	796	60	24	IPR015880
Domain	-	ZBTB7A ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 ZNF423 ZNF641 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 ZNF510 ZNF468 ZKSCAN5 ZBTB14 ZNF404 ZNF697	9.19e-16	679	60	21	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZBTB7A ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 ZNF423 ZNF641 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 ZNF510 ZNF468 ZKSCAN5 ZBTB14 ZNF404 ZNF697	1.42e-15	694	60	21	IPR013087
Domain	KRAB	ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 ZNF641 ZNF813 ZNF816 ZNF480 ZNF701 ZNF510 ZNF468 ZKSCAN5 ZNF404	5.48e-12	358	60	14	PS50805
Domain	KRAB	ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 ZNF641 ZNF813 ZNF816 ZNF480 ZNF701 ZNF510 ZNF468 ZKSCAN5 ZNF404	5.48e-12	358	60	14	PF01352
Domain	KRAB	ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 ZNF641 ZNF813 ZNF816 ZNF480 ZNF701 ZNF510 ZNF468 ZKSCAN5 ZNF404	8.23e-12	369	60	14	SM00349
Domain	KRAB	ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 ZNF641 ZNF813 ZNF816 ZNF480 ZNF701 ZNF510 ZNF468 ZKSCAN5 ZNF404	8.53e-12	370	60	14	IPR001909
Domain	zf-C2H2_6	ZNF845 ZNF320 ZNF423 ZNF813 ZNF816 ZNF521 ZNF480 ZNF701 ZNF468 ZKSCAN5 ZNF404	4.19e-09	314	60	11	PF13912
Domain	SCAN	ZNF263 ZNF394 ZKSCAN5	7.74e-04	56	60	3	SM00431
Domain	SCAN_BOX	ZNF263 ZNF394 ZKSCAN5	8.58e-04	58	60	3	PS50804
Domain	SCAN	ZNF263 ZNF394 ZKSCAN5	8.58e-04	58	60	3	PF02023
Domain	SCAN_dom	ZNF263 ZNF394 ZKSCAN5	8.58e-04	58	60	3	IPR003309
Domain	Retrov_capsid_C	ZNF263 ZNF394 ZKSCAN5	9.02e-04	59	60	3	IPR008916
Domain	dsrm	ADARB2 DHX30	1.86e-03	20	60	2	PF00035
Domain	DS_RBD	ADARB2 DHX30	2.05e-03	21	60	2	PS50137
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF845 ZNF320 REXO5 ZNF813 ZNF480 ZNF701 ZNF468 ZNF697	1.07e-09	181	61	8	37372979
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZBTB7A ZNF263 ZNF394 WIZ ZNF592 BAZ2A ZNF423 ZNF451 KLF15 ZNF697	1.34e-06	808	61	10	20412781
Pubmed	Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein.	ZNF423 ZNF521	3.03e-06	2	61	2	12393497
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF263 ZNF845 ZNF320 RAB34 USP42 ATP6AP2 ZNF451 NOL6 ZNF813 ZNF468 ZNF697	6.93e-06	1203	61	11	29180619
Pubmed	Direct transcriptional repression of Zfp423 by Zfp521 mediates a bone morphogenic protein-dependent osteoblast versus adipocyte lineage commitment switch.	ZNF423 ZNF521	9.07e-06	3	61	2	24891617
Pubmed	ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies.	ZNF423 ZNF521	9.07e-06	3	61	2	26788497
Pubmed	Three novel spermatogenesis-specific zinc finger genes.	ZNF394 ZKSCAN5	1.81e-05	4	61	2	12860387
Pubmed	Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.	ZNF423 ZNF521	3.02e-05	5	61	2	14630787
Pubmed	A Y2H-seq approach defines the human protein methyltransferase interactome.	WIZ ZNF451 ZNF641 KLF15 ZNF480 ZKSCAN5	3.05e-05	342	61	6	23455924
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CEP170 ZBTB7A SLC25A12 WIZ ZNF592 BAZ2A WDR20 ZKSCAN5 SEZ6L	1.35e-04	1116	61	9	31753913
Pubmed	Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.	ZNF423 ZNF521	3.57e-04	16	61	2	17521568
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	PPARGC1B REXO5 TUT1 ADARB2 DHX30	3.62e-04	347	61	5	16033648
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF263 WIZ ZNF423 ZNF521 ZBTB14	3.81e-04	351	61	5	38297188
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	WIZ TIAM1 ZNF592 ZNF423 ZNF451 ZNF521 ZKSCAN5 SEZ6L DHX30	3.84e-04	1285	61	9	35914814
Pubmed	Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.	PCSK2 RAB34 ATP6AP2	4.74e-04	86	61	3	25044020
Pubmed	Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.	ZBTB7A WIZ	5.08e-04	19	61	2	30385546
Pubmed	PDGFRα controls the balance of stromal and adipogenic cells during adipose tissue organogenesis.	ZNF423 ZNF521	5.08e-04	19	61	2	28049691
Pubmed	A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci.	ADAMTS16 MTRR	5.63e-04	20	61	2	15329828
Pubmed	A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.	GPLD1 CARMIL1 MTRR ZNF701	5.92e-04	218	61	4	19460752
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	WIZ ZNF451 ZBTB12 DHX30	6.34e-04	222	61	4	37071664
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF845 WIZ ZNF592 BAZ2A ZNF451 ZNF813	6.84e-04	608	61	6	36089195
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	BAZ2A ZNF423 ZNF451 SEZ6L DHX30	7.44e-04	407	61	5	12693553
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZNF510 ZKSCAN5 SEZ6L	7.79e-04	102	61	3	10231032
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	WIZ ZNF592 BAZ2A	8.01e-04	103	61	3	32744500
Pubmed	Human transcription factor protein interaction networks.	ZBTB7A WIZ ZNF592 ZNF451 WDR20 ZNF521 KLF15 ZBTB14 DHX30	8.22e-04	1429	61	9	35140242
Pubmed	C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.	CEP170 RPL3L	1.03e-03	27	61	2	29420262
Pubmed	Robo1 modulates proliferation and neurogenesis in the developing neocortex.	TGFB2 ZNF423	1.03e-03	27	61	2	24741061
Pubmed	Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming.	TGFB2 PPARGC1B	1.11e-03	28	61	2	28159809
Pubmed	Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha.	TGFB2 RAB34	1.19e-03	29	61	2	18239623
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CEP170 ZNF845 ZNF777 WIZ BAZ2A ZNF451 NOL6	1.38e-03	954	61	7	36373674
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	ZNF777 ZNF451 ZBTB12	1.40e-03	125	61	3	32891193
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZNF777 BAZ2A ZNF521 TUT1 ZKSCAN5 ZBTB14	1.51e-03	709	61	6	22988430
Pubmed	eXPRESSION: an in silico tool to predict patterns of gene expression.	PCSK2 SEZ6L	1.73e-03	35	61	2	15939374
Interaction	ZFP37 interactions	ZNF423 KLF15 ZBTB14 ZNF697	1.36e-05	49	60	4	int:ZFP37
Interaction	ZNF467 interactions	ZNF845 ZNF320 ZNF451 ZNF813 ZNF480 DHX30	1.52e-05	179	60	6	int:ZNF467
Interaction	ZNF667 interactions	ZNF423 KLF15 ZBTB14 ZNF697	1.86e-05	53	60	4	int:ZNF667
Interaction	ZNF287 interactions	ZNF423 KLF15 ZBTB14 ZNF697	3.06e-05	60	60	4	int:ZNF287
Interaction	ZBTB48 interactions	ZBTB7A ZNF777 ZNF423 NOL6 ZBTB14	1.07e-04	158	60	5	int:ZBTB48
Interaction	MYNN interactions	ZNF423 KLF15 ZBTB14	1.17e-04	32	60	3	int:MYNN
Interaction	LTBP2 interactions	ZNF263 ZNF777 ZNF320 ZNF480	1.20e-04	85	60	4	int:LTBP2
Cytoband	19q13.41	ZNF320 ZNF816 ZNF480 ZNF701 ZNF468	6.86e-08	78	61	5	19q13.41
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF845 ZNF320 ZNF813 ZNF816 ZNF480 ZNF701 ZNF468 ZNF404	1.76e-04	1192	61	8	chr19q13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB7A ZNF263 ZNF845 ZNF777 ZNF320 ZNF394 WIZ ZNF592 ZNF423 ZNF451 ZNF641 ZNF813 ZNF816 ZNF521 KLF15 ZNF480 ZNF701 ZBTB12 ZNF510 ZNF468 ZKSCAN5 ZBTB14 ZNF404 ZNF697	5.62e-22	718	46	24	28
Disease	hormone measurement, testosterone measurement	ZNF394 ZKSCAN5	1.22e-05	3	60	2	EFO_0004730, EFO_0004908
Disease	hormone measurement, progesterone measurement	ZNF394 ZKSCAN5	4.05e-05	5	60	2	EFO_0004730, EFO_0007004
Disease	hormone measurement, dehydroepiandrosterone sulphate measurement	ZNF394 ZKSCAN5	4.05e-05	5	60	2	EFO_0004730, EFO_0007001
Disease	androsterone sulfate measurement	ZBTB7A ZNF394 ZKSCAN5	4.18e-05	33	60	3	EFO_0021117
Disease	carboxypeptidase B2 measurement	TMEM232 SIAH3	1.81e-04	10	60	2	EFO_0008069
Disease	urgency urinary incontinence	ADAMTS16 ZNF521	2.65e-04	12	60	2	EFO_0006865
Disease	male infertility (implicated_via_orthology)	CFAP47 ADAMTS16	3.13e-04	13	60	2	DOID:12336 (implicated_via_orthology)
Disease	X-21410 measurement	ZNF394 ZKSCAN5	4.79e-04	16	60	2	EFO_0800813
Disease	5alpha-androstan-3beta,17beta-diol disulfate measurement	ZNF394 ZKSCAN5	9.15e-04	22	60	2	EFO_0021115
Disease	epiandrosterone sulfate measurement	ZBTB7A ZNF394	1.18e-03	25	60	2	EFO_0021120
Disease	lung carcinoma, family history of lung cancer	PCSK2 ADARB2	1.59e-03	29	60	2	EFO_0001071, EFO_0006953
Disease	immature platelet fraction	BAZ2A CARMIL1 SEC14L5	1.64e-03	114	60	3	EFO_0009187
Disease	immature platelet measurement	BAZ2A CARMIL1 SEC14L5	1.85e-03	119	60	3	EFO_0803541
Disease	fibroblast growth factor 23 measurement	TGFB2 SIAH3	3.48e-03	43	60	2	EFO_0009381

Protein segments in the cluster

Peptide	Gene	Start	Entry
LEEHLRRHHSEHKKL	CEP170	396	Q5SW79
HPRGIREKALHKHLN	BAZ2A	1456	Q9UIF9
REKALHKHLNKHRDF	BAZ2A	1461	Q9UIF9
RKLGLHDFDHFHSLA	BCDIN3D	211	Q7Z5W3
ILAKLGKHQYLHRHR	DHX30	626	Q7L2E3
SLHLRLKGSRHDFHM	ADAMTS16	96	Q8TE57
RKEAALHGHKDFHPR	RAB34	21	Q9BZG1
HSSKHLVRKFRGHLR	ADARB2	506	Q9NS39
RKRFKVLRADHTHLH	FOXB2	106	Q5VYV0
KELRHFLKHGILTHL	MTRR	591	Q9UBK8
RKRALYLAHLAHHLA	NOL6	201	Q9H6R4
LLSRHKHLAKDHSPD	ATP6AP2	196	O75787
KRKDFLAHIIHHLAA	CERS3	201	Q8IU89
AYREERERKHHLKHG	GJB4	96	Q9NTQ9
HGHLRLKEHIDRKFV	FKTN	186	O75072
ILHKGSHHERKIRGS	NSMAF	41	Q92636
SHLKAHLRRHTGEKP	KLF15	336	Q9UIH9
HHKLADHFSRRGKTL	CARMIL1	861	Q5VZK9
SRKHRKLLHGIHRAD	GADL1	311	Q6ZQY3
HILRFLRAHDFHLDK	SEC14L5	266	O43304
RAATIRSKDHHKHFR	CFAP47	591	Q6ZTR5
LHLHFERLLLHDKDR	SEZ6L	491	Q9BYH1
FLPHKRSHRHRGKVK	RPL3L	16	Q92901
KKHPERSELLSHLRH	PPARGC1B	656	Q86YN6
HFLLVLRKQERHEGH	SIAH3	166	Q8IW03
FLHHRGEPRLLEKHA	WIZ	116	O95785
LHDRKERHHEKDHKR	WDR20	466	Q8TBZ3
EFIRLHFGHNRKKHL	SLC25A12	131	O75746
KANLSRHHRLHTGEK	ZNF845	871	Q96IR2
LHHKDRNLGFKISLH	TGFB2	211	P61812
LVHGDKREAKAHLHA	TDP1	226	Q9NUW8
KHKSHLKDHERRHRG	ZBTB14	371	O43829
DNGHLLLGHLKRFDH	ZNF451	181	Q9Y4E5
FHEHENGKSRKRRHD	USP42	1151	Q9H9J4
RSDLFKHHRIHTGEK	ZNF394	481	Q53GI3
HKPAIRRHLKEQHGK	ZBTB12	426	Q9Y330
DSHLAKHTRIHRGDK	ZNF320	201	A2RRD8
ARHHHKEDTLRLLKS	TIAM1	551	Q13009
LHGHLESFKQHLLRL	TMEM232	181	C9JQI7
LDAHLGGRKHRHLVE	TUT1	31	Q9H6E5
KLKGRHALTPRHLHA	REXO5	666	Q96IC2
KHKRSRDRHIKLHTG	ZNF521	156	Q96K83
SLLRHARDHKSKGLV	ZNF592	631	Q92610
SRLGHLLHIRDEKKS	GPLD1	606	P80108
ARDKHHLADLSHLIR	RIMKLB	171	Q9ULI2
LARHHRLHSGEKPYK	ZNF813	426	Q6ZN06
KANLARHHRLHTGEK	ZNF813	591	Q6ZN06
FQHFIRHRKIHTDLK	ZNF404	171	Q494X3
RADLLKHRRLHTGEK	ZNF697	301	Q5TEC3
AHLARHRKIHTGEKP	ZNF480	496	Q8WV37
LFDHRRTGTGKKHLH	ZNF510	296	Q9Y2H8
KHKRSRDRHIKLHTG	ZNF423	176	Q2M1K9
FHAIILLEKHLREKH	ZNF423	816	Q2M1K9
KSNLERHHRLHTGKK	ZNF701	516	Q9NV72
GKSFIRKHHLLEHRR	ZNF777	756	Q9ULD5
KSHLERHKRIHTGEK	ZNF468	311	Q5VIY5
VRSDHLHRHLKKDGC	ZBTB7A	476	O95365
RHKGAKHLRVAAHDL	UGT2A2	476	P0DTE5
LARHHRLHAGEKPYK	ZNF816	496	Q0VGE8
GKNFGRHSHLIEHLK	ZKSCAN5	436	Q9Y2L8
FLSLHRAHLGEEAHK	ZNF263	421	O14978
EKSFGRKHHLDRHLL	ZNF641	406	Q96N77
HHGIAEKDRKLLEHL	NLRP14	151	Q86W24
HNGLAKAKRRRSLHH	PCSK2	71	P16519