Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

HHEX SP100 CDX2 CDX4 ALX1 LHX4 SPIB ZSCAN5DP ZNF540 HMX3 SHOX ZNF727 LHX3 MLXIP HMX1 USF2 HESX1

2.52e-0514127817GO:0000981
GeneOntologyMolecularFunctionATP hydrolysis activity

IQCA1L ERCC6 DDX54 ABCB11 MORC4 SMC5 DNAH9 KIF1C

3.22e-04441788GO:0016887
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

HHEX CDX4 ALX1 LHX4 SPIB SHOX ZNF727 LHX3 MLXIP

3.29e-04560789GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

HHEX CDX4 ALX1 LHX4 SPIB SHOX ZNF727 LHX3 MLXIP

3.55e-04566789GO:0001216
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

HHEX CDX2 CDX4 ALX1 LHX4 SPIB ZSCAN5DP ZNF540 HMX3 ZNF727 LHX3 MLXIP HMX1 USF2 HESX1

4.60e-0414597815GO:0000977
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

IQCA1L ARL3 ERCC6 DDX54 ABCB11 GNAS MORC4 SMC5 DNAH9 KIF1C

8.48e-047757810GO:0017111
GeneOntologyBiologicalProcessmedial motor column neuron differentiation

LHX4 LHX3

1.38e-052772GO:0021526
GeneOntologyCellularComponentchromatin

HHEX CDX2 CDX4 ERCC6 ALX1 LHX4 SPIB CENPA HMX3 SHOX LHX3 KAT2A MLXIP HMX1 USF2 HESX1

6.87e-0514807616GO:0000785
HumanPhenoReduced circulating prolactin concentration

LHX4 LHX3 GNAS HESX1

8.67e-0622324HP:0008202
HumanPhenoAbnormal thyroid-stimulating hormone level

LHX4 LHX3 GNAS SMC5 HESX1

8.99e-0647325HP:0031097
HumanPhenoInappropriate antidiuretic hormone secretion

LHX4 LHX3 HESX1

1.23e-058323HP:0031218
HumanPhenoPituitary dwarfism

LHX4 LHX3 HESX1

2.62e-0510323HP:0000839
HumanPhenoDecreased circulating ACTH concentration

LHX4 LHX3 GNAS HESX1

3.14e-0530324HP:0002920
HumanPhenoAbnormal prolactin level

LHX4 LHX3 GNAS HESX1

3.14e-0530324HP:0040086
HumanPhenoDecreased thyroid-stimulating hormone level

LHX4 LHX3 HESX1

4.77e-0512323HP:0031098
HumanPhenoMaternal autoimmune disease

LHX4 LHX3 HESX1

7.82e-0514323HP:0011437
HumanPhenoAbnormal radioactive iodine uptake test result

LHX4 LHX3 HESX1

7.82e-0514323HP:0031221
HumanPhenoReduced radioactive iodine uptake

LHX4 LHX3 HESX1

7.82e-0514323HP:0031219
HumanPhenoDecreased cervical spine mobility

LHX4 LHX3 HESX1

9.74e-0515323HP:0004637
HumanPhenoDelayed proximal femoral epiphyseal ossification

LHX4 LHX3 HESX1

1.44e-0417323HP:0008828
HumanPhenoAbnormal circulating adrenocorticotropin concentration

LHX4 LHX3 GNAS HESX1

1.46e-0444324HP:0011043
HumanPhenoLarge posterior fontanelle

LHX4 LHX3 HESX1

2.04e-0419323HP:0004491
HumanPhenoOsteoporosis of vertebrae

LHX4 HESX1 BMP15

2.39e-0420323HP:0005625
HumanPhenoEctopic posterior pituitary

LHX4 LHX3 HESX1

2.77e-0421323HP:0011755
HumanPhenoAbnormal circulating thyroglobulin concentration

LHX4 LHX3 HESX1

3.20e-0422323HP:0025483
HumanPhenoLocalized osteoporosis

LHX4 HESX1 BMP15

3.20e-0422323HP:0040161
HumanPhenoThyroid hypoplasia

LHX4 LHX3 HESX1

3.66e-0423323HP:0005990
HumanPhenoDecreased circulating T4 concentration

LHX4 LHX3 HESX1

3.66e-0423323HP:0031507
HumanPhenoPosterior pituitary dysgenesis

LHX4 LHX3 HESX1

4.17e-0424323HP:0011753
HumanPhenoAbnormal ossification involving the femoral head and neck

LHX4 LHX3 HESX1

4.72e-0425323HP:0009107
HumanPhenoAplasia/Hypoplasia of the thyroid gland

LHX4 LHX3 HESX1

4.72e-0425323HP:0033079
HumanPhenoThyroid dysgenesis

LHX4 LHX3 HESX1

5.31e-0426323HP:0008188
HumanPhenoAbnormal circulating T4 concentration

LHX4 LHX3 HESX1

5.31e-0426323HP:0031505
MousePhenosmall adenohypophysis

LHX4 HMX3 LHX3 HESX1

3.53e-0623654MP:0008321
MousePhenoabnormal Rathke's pouch development

LHX4 LHX3 HESX1

1.13e-0510653MP:0013351
MousePhenoabnormal pituitary diverticulum morphology

HHEX LHX4 LHX3 HESX1

2.24e-0536654MP:0003817
MousePhenoabnormal adenohypophysis development

HHEX LHX4 LHX3 HESX1

2.79e-0538654MP:0013337
MousePhenoabnormal pituitary gland development

HHEX LHX4 LHX3 HESX1

4.17e-0542654MP:0003816
MousePhenoabnormal adenohypophysis morphology

HHEX LHX4 HMX3 LHX3 HESX1

6.69e-0592655MP:0004163
DomainHomeobox_CS

HHEX CDX2 CDX4 ALX1 LHX4 HMX3 SHOX LHX3 HMX1 HESX1

4.64e-091867710IPR017970
DomainHomeobox

HHEX CDX2 CDX4 ALX1 LHX4 HMX3 SHOX LHX3 HMX1 HESX1

4.14e-082347710PF00046
DomainHOMEOBOX_1

HHEX CDX2 CDX4 ALX1 LHX4 HMX3 SHOX LHX3 HMX1 HESX1

4.49e-082367710PS00027
DomainHOX

HHEX CDX2 CDX4 ALX1 LHX4 HMX3 SHOX LHX3 HMX1 HESX1

4.67e-082377710SM00389
DomainHOMEOBOX_2

HHEX CDX2 CDX4 ALX1 LHX4 HMX3 SHOX LHX3 HMX1 HESX1

5.05e-082397710PS50071
DomainHomeobox_dom

HHEX CDX2 CDX4 ALX1 LHX4 HMX3 SHOX LHX3 HMX1 HESX1

5.05e-082397710IPR001356
Domain-

HHEX CDX2 CDX4 ALX1 LHX4 HMX3 SHOX LHX3 HMX1 HESX1

2.44e-0728377101.10.10.60
DomainHomeodomain-like

HHEX CDX2 CDX4 ALX1 LHX4 HMX3 SHOX LHX3 HMX1 HESX1

1.05e-063327710IPR009057
DomainHTH_motif

HHEX CDX2 CDX4 SHOX HMX1

9.55e-0669775IPR000047
DomainASH

ASPM HYDIN

1.68e-052772IPR031549
DomainASH

ASPM HYDIN

1.68e-052772PF15780
DomainHomeobox_metazoa

HHEX CDX2 CDX4 HMX3 HMX1

3.49e-0590775IPR020479
DomainCaudal_act

CDX2 CDX4

5.02e-053772PF04731
DomainCaudal_activation_dom

CDX2 CDX4

5.02e-053772IPR006820
DomainSpectrin_repeat

DRP2 DSP SPTAN1

2.28e-0429773IPR002017
DomainSpectrin/alpha-actinin

DRP2 DSP SPTAN1

3.07e-0432773IPR018159
DomainSPEC

DRP2 DSP SPTAN1

3.07e-0432773SM00150
DomainPX

PLD1 SNX11 SNX13

7.90e-0444773SM00312
Domain6-blade_b-propeller_TolB-like

TENM3 EIF3B LRP1B

9.00e-0446773IPR011042
DomainPX

PLD1 SNX11 SNX13

1.08e-0349773PF00787
DomainPX

PLD1 SNX11 SNX13

1.15e-0350773PS50195
Domain-

PLD1 SNX11 SNX13

1.22e-03517733.30.1520.10
DomainPhox

PLD1 SNX11 SNX13

1.29e-0352773IPR001683
DomainOAR

ALX1 SHOX

1.70e-0315772PF03826
DomainOAR

ALX1 SHOX

1.94e-0316772PS50803
DomainOAR_dom

ALX1 SHOX

1.94e-0316772IPR003654
DomainGprotein_alpha_su

ARL3 GNAS

2.19e-0317772IPR001019
DomainPept_M10A_stromelysin-type

MMP14 MMP19

2.46e-0318772IPR016293
DomainP-loop_NTPase

ARL3 ERCC6 DDX54 ASPM ABCB11 GNAS SMC5 DNAH9 HYDIN KIF1C

2.46e-038487710IPR027417
DomainPG_binding_1

MMP14 MMP19

3.04e-0320772PF01471
DomainPeptidoglycan-bd-like

MMP14 MMP19

3.04e-0320772IPR002477
DomainHemopexin-like_dom

MMP14 MMP19

4.01e-0323772IPR000585
DomainHemopexin-like_repeat

MMP14 MMP19

4.01e-0323772IPR018487
DomainSpectrin

DRP2 SPTAN1

4.01e-0323772PF00435
DomainM10A_MMP

MMP14 MMP19

4.01e-0323772IPR033739
DomainHemopexin

MMP14 MMP19

4.01e-0323772PF00045
DomainHEMOPEXIN

MMP14 MMP19

4.01e-0323772PS00024
Domain-

MMP14 MMP19

4.01e-03237722.110.10.10
DomainHEMOPEXIN_2

MMP14 MMP19

4.01e-0323772PS51642
DomainHX

MMP14 MMP19

4.01e-0323772SM00120
DomainPept_M10A

MMP14 MMP19

4.01e-0323772IPR021190
DomainPeptidase_M10

MMP14 MMP19

4.37e-0324772PF00413
DomainZnMc

MMP14 MMP19

6.34e-0329772SM00235
DomainPeptidase_Metallo

MMP14 MMP19

6.34e-0329772IPR006026
Pubmed

A census of human transcription factors: function, expression and evolution.

HHEX SP100 CDX2 CDX4 ALX1 LHX4 HMX3 SHOX LHX3 MLXIP HMX1 USF2 HESX1

1.29e-07908791319274049
Pubmed

Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion.

LHX4 LHX3 HESX1

2.24e-07679320534763
Pubmed

Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene.

LHX4 LHX3 HESX1

3.92e-07779314714741
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

HHEX CDX4 ALX1 HMX3 LHX3 HMX1 HESX1

2.38e-0626379720932939
Pubmed

Specification of pituitary cell lineages by the LIM homeobox gene Lhx3.

LHX4 LHX3 HESX1

2.45e-06127938638120
Pubmed

Molecular basis of pituitary dysfunction in mouse and human.

LHX4 LHX3 HESX1

2.45e-061279311420609
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

CDX2 CDX4 ALX1 LHX4 SPIB SHOX HMX1 USF2 HESX1

4.09e-0654479928473536
Pubmed

Co-expression of MMP-14 and MMP-19 predicts poor survival in human glioma.

MMP14 MMP19

5.09e-06279222855183
Pubmed

The caudal-related homeodomain protein Cdx-2/3 regulates glucagon gene expression in islet cells.

CDX2 CDX4

5.09e-0627928910549
Pubmed

Molecular cloning and expression analysis of the mouse Spot-2 gene in pituitary development.

LHX4 LHX3

5.09e-06279212684778
Pubmed

Clinicopathological and prognostic significance of α5β1-integrin and MMP-14 expressions in colorectal cancer.

ITGA5 MMP14

5.09e-06279223373994
Pubmed

TopBP1 deficiency impairs V(D)J recombination during lymphocyte development.

TOPBP1 CD79A

5.09e-06279224442639
Pubmed

Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons.

LHX4 LHX3

5.09e-06279238970652
Pubmed

Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model.

CD22 CD79A

5.09e-06279228972089
Pubmed

Cdx mutant axial progenitor cells are rescued by grafting to a wild type environment.

CDX2 CDX4

5.09e-06279220816799
Pubmed

Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development.

ARL3 CEP120

5.09e-06279233297941
Pubmed

Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development.

LHX4 LHX3

5.09e-06279215567726
Pubmed

Pituitary stalk interruption syndrome in 83 patients: novel HESX1 mutation and severe hormonal prognosis in malformative forms.

LHX4 HESX1

5.09e-06279221270112
Pubmed

RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking.

GNAS SNX13

5.09e-06279211729322
Pubmed

Location of transient ectodermal progenitor potential in mouse development.

HHEX CDX2 HESX1

7.50e-061779324131634
Pubmed

Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.

TENM3 ECRG4 ABCB11

8.98e-061879324058526
Pubmed

Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning.

HHEX CDX2 HESX1

1.25e-052079315829518
Pubmed

cdx4/lacZ and cdx2/lacZ protein gradients formed by decay during gastrulation in the mouse.

CDX2 CDX4

1.53e-05379216281167
Pubmed

Molecular analysis of brazilian patients with combined pituitary hormone deficiency and orthotopic posterior pituitary lobe reveals eight different PROP1 alterations with three novel mutations.

LHX3 HESX1

1.53e-05379228734020
Pubmed

Cdx4 is a Cdx2 target gene.

CDX2 CDX4

1.53e-05379220933081
Pubmed

Cdx gene deficiency compromises embryonic hematopoiesis in the mouse.

CDX2 CDX4

1.53e-05379218511567
Pubmed

PU.1 Regulates Ig Light Chain Transcription and Rearrangement in Pre-B Cells during B Cell Development.

SPIB CD79A

1.53e-05379228062693
Pubmed

Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site.

HMX3 HMX1

1.53e-05379210206974
Pubmed

[Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia].

CDX2 CDX4

1.53e-05379221518475
Pubmed

Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors.

LHX4 LHX3

1.53e-05379210788441
Pubmed

Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.

LHX4 LHX3

1.53e-05379218425848
Pubmed

Anterior expression of the caudal homologue cCdx-B activates a posterior genetic program in avian embryos.

CDX2 CDX4

1.53e-05379211500978
Pubmed

An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase.

ITGA5 MMP14

1.53e-05379211741954
Pubmed

Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family.

HMX3 HMX1

1.53e-0537927647458
Pubmed

Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes.

CDX2 CDX4

1.53e-05379218252864
Pubmed

Pituitary stalk interruption syndrome in 58 Chinese patients: clinical features and genetic analysis.

LHX4 HESX1

1.53e-05379223199197
Pubmed

Hmx: an evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila.

HMX3 HMX1

1.53e-05379211091080
Pubmed

Cullin 3 Is Crucial for Pro-B Cell Proliferation, Interacts with CD22, and Controls CD22 Internalization on B Cells.

CD22 CD79A

1.53e-05379232341059
Pubmed

Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.

HHEX MMP14 HESX1

2.50e-052579325664857
Pubmed

Conserved regulatory elements establish the dynamic expression of Rpx/HesxI in early vertebrate development.

LHX3 HESX1

3.05e-05479216527264
Pubmed

Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study.

LHX3 HESX1

3.05e-05479225500790
Pubmed

Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries.

DNAH9 HYDIN

3.05e-05479236140829
Pubmed

Increased Cdx protein dose effects upon axial patterning in transgenic lines of mice.

CDX2 CDX4

3.05e-05479218579683
Pubmed

Nervous System Regionalization Entails Axial Allocation before Neural Differentiation.

CDX2 CDX4

3.05e-05479230343898
Pubmed

IMP3, NESP55, TTF-1 and CDX2 serve as an immunohistochemical panel in the distinction among small-cell carcinoma, gastrointestinal carcinoid, and pancreatic endocrine tumor metastasized to the liver.

CDX2 GNAS

3.05e-05479222495359
Pubmed

Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3.

SPTAN1 LHX3

3.05e-0547927665181
Pubmed

Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.

LHX4 LHX3

3.05e-05479222025611
Pubmed

Dosage requirement of Pitx2 for development of multiple organs.

LHX3 HESX1

3.05e-05479210498698
Pubmed

P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein.

KAT2A HSD11B2

3.05e-05479212878208
Pubmed

Clinical characteristics and molecular analysis of PIT1, PROP1,LHX3, and HESX1 in combined pituitary hormone deficiency patients with abnormal pituitary MR imaging.

LHX3 HESX1

3.05e-05479214646405
Pubmed

IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta.

CD22 CD79A

5.07e-05579217420268
Pubmed

Axis duplication and anterior identity in the mouse embryo.

HHEX HESX1

5.07e-0557929598343
Pubmed

Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons.

LHX4 LHX3

5.07e-05579215607939
Pubmed

Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex.

CD22 CD79A

5.07e-0557929120258
Pubmed

Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation.

CDX2 CDX4

5.07e-05579216325584
Pubmed

Cdx1 and Cdx2 are functionally equivalent in vertebral patterning.

CDX2 CDX4

5.07e-05579219328777
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

URB1 CEP120 ASPM TOPBP1 CCDC85C EIF3B NIBAN2 GNAS SMC5 GCN1 KIF1C

5.92e-051155791120360068
Pubmed

Getting your head around Hex and Hesx1: forebrain formation in mouse.

HHEX HESX1

7.60e-05679211291863
Pubmed

Coordinated changes in glycosylation regulate the germinal center through CD22.

CD22 CD79A

7.60e-05679235294874
Pubmed

Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).

MMP14 MMP19

1.06e-04779210922468
Pubmed

Developmental regulation of the Hox genes during axial morphogenesis in the mouse.

CDX2 CDX4

1.06e-04779215944185
Pubmed

Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells.

CDX2 CDX4

1.06e-04779219371634
Pubmed

Role of Cdx factors in early mesodermal fate decisions.

CDX2 CDX4

1.41e-04879230936115
Pubmed

A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous system.

CDX2 EIF3B

1.41e-04879227747430
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DSP SPTAN1 CCDC85C ARHGEF4 GNAS MLXIP RNF180 CDC14A KIF1C

1.47e-0486179936931259
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

URB1 ARHGEF4 MED13L SMC5 GCN1

1.66e-0422579512168954
Pubmed

Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets.

CDX2 CDX4

1.82e-04979215888377
Pubmed

NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network.

CD22 CD79A

1.82e-04979221464221
Pubmed

Formation of Rathke's pouch requires dual induction from the diencephalon.

LHX4 LHX3

1.82e-0497929806931
Pubmed

Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice.

HHEX HESX1

1.82e-04979223085236
Pubmed

Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene.

HMX3 HMX1

1.82e-0497929435283
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

URB1 SFI1 KAT2A ARHGEF4 SNX11 MLXIP MED13L ITGA5 MMP14 GCN1

1.99e-041105791035748872
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

HHEX CDX4 HMX3 KAT2A HMX1 USF2 RNF180 HESX1

2.09e-0470979822988430
Pubmed

The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages.

HHEX HESX1

2.27e-041079218854136
Pubmed

Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway.

HHEX CDX2

2.27e-041079216678776
Pubmed

Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development.

HHEX ITGA5

2.27e-041079211809759
Pubmed

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.

FADD CARD16

2.27e-041079211821383
Pubmed

Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.

LHX4 LHX3 HESX1

2.72e-045579328807898
Pubmed

Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes.

MMP14 MMP19

2.76e-041179210949161
Pubmed

Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia.

LHX4 LHX3

2.76e-041179225668206
Pubmed

Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice.

ITGA5 MMP14

2.76e-041179236465133
Pubmed

Activator-Mediator binding regulates Mediator-cofactor interactions.

KAT2A GCN1

2.76e-041179220534441
Pubmed

Gene expression in the developing mouse retina by EST sequencing and microarray analysis.

TENM3 SPTAN1 ASPM PRSS23

3.16e-0414279411812828
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

URB1 ERCC6 NRBF2 DDX54 ASPM TOPBP1 SMC5 GCN1

3.31e-0475979835915203
Pubmed

Dkk1 and noggin cooperate in mammalian head induction.

HHEX HESX1

3.31e-041279212952897
Pubmed

Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes.

LHX4 LHX3

3.31e-041279215053981
Pubmed

Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression.

CDX2 CDX4

3.31e-041279211335109
Pubmed

Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition.

TOPBP1 EIF3B SMC5

3.35e-045979331551363
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TENM3 ARHGEF4 MLXIP MED13L SMC5 SNX13

3.35e-0440779612693553
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

DSP SPTAN1 SFI1 NIBAN2 GNAS RNF17 GCN1

3.63e-0458279720467437
Pubmed

The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo.

HHEX HESX1

3.91e-041379216368929
Pubmed

Borcs6 is required for endo-lysosomal degradation during early development.

HHEX CDX2

3.91e-041379235726782
Pubmed

Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse.

TUT4 PAN2

3.91e-041379231777931
Pubmed

LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons.

LHX4 LHX3

3.91e-04137929865699
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

DSP SPTAN1 EIF3B MED13L GCN1

3.96e-0427279531010829
Pubmed

The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation.

HHEX HESX1

4.55e-041479210804184
Pubmed

Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension.

CDX2 CDX4

4.55e-041479219539783
Pubmed

Essential roles for Cdx in murine primitive hematopoiesis.

CDX2 CDX4

4.55e-041479228065741
Pubmed

Depletion of definitive gut endoderm in Sox17-null mutant mice.

HHEX CDX2

4.55e-041479211973269
Pubmed

Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation.

MMP14 MMP19

4.55e-041479225636537
GeneFamilyLIM class homeoboxes

LHX4 LHX3

7.23e-0412612522
GeneFamilyNKL subclass homeoboxes and pseudogenes

HHEX HMX3 HMX1

1.50e-0367613519
CoexpressionGSE22886_TCELL_VS_BCELL_NAIVE_DN

TMEM156 HHEX SPIB CD22 DSP CD79A HYDIN HESX1 SNX13

7.76e-09198789M4426
CoexpressionGSE22886_NAIVE_BCELL_VS_MONOCYTE_UP

TMEM156 SPIB CD22 DSP CD79A MORC4 CFAP44 HYDIN

1.32e-07197788M4485
CoexpressionTRAVAGLINI_LUNG_B_CELL

TMEM156 HHEX SP100 SPIB CD22 CD79A

7.02e-06155786M41680
CoexpressionGSE6269_FLU_VS_STAPH_AUREUS_INF_PBMC_UP

TMEM156 SPIB CD22 PAN2 SFI1 KAT2A

1.92e-05185786M5643
CoexpressionGSE10325_BCELL_VS_MYELOID_UP

TMEM156 TUT4 SPIB CD22 DSP CD79A

2.74e-05197786M3081
CoexpressionGSE41867_NAIVE_VS_DAY6_LCMV_EFFECTOR_CD8_TCELL_DN

TUT4 CEP120 TPRG1L DDX54 CD79A CDC14A

2.98e-05200786M9463
CoexpressionGSE40273_EOS_KO_VS_WT_TREG_DN

SPIB CD22 SFI1 USF2 CDC14A KIF1C

2.98e-05200786M9130
CoexpressionHAY_BONE_MARROW_FOLLICULAR_B_CELL

TMEM156 SP100 SPIB CD22 CD79A

6.68e-05142785M39198
ToppCellnormal-na-Lymphocytic_B-B_naive-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SP100 SPIB CD22 DSP CD79A

4.47e-08188797ec72ba73b10c6f2ff39699b6b46b90a3e95a4c24
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-B_naive|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SPIB CD22 DSP ZDHHC22 CD79A

4.81e-08190797e63945fa1dcd58bee129f1dd0c23b64a76241554
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-B_naive-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SPIB CD22 DSP ZDHHC22 CD79A

4.81e-08190797fa65bc5a178ae0c80a9bd4b282e4539493128a64
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 SP100 SPIB CD22 DSP ZDHHC22 CD79A

4.98e-081917978dda37ebf74b587129795f61541cc511ec97a314
ToppCellnormal-na-Lymphocytic_B-B_naive|normal / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SP100 SPIB CD22 DSP CD79A

5.35e-0819379798279a3c69f1df062c4a8333e46c8fd649bf86b1
ToppCellnormal-na-Lymphocytic_B-B_naive-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SP100 SPIB CD22 DSP CD79A

5.35e-08193797dd199163fc13f3d411fe741cf003237064349e22
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_naive-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SP100 SPIB CD22 DSP CD79A

5.54e-0819479783554ba6a789750a39af58537fd7044ce20d3f02
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_naive|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SP100 SPIB CD22 DSP CD79A

5.54e-0819479756286db641cfb270e52f33989b8bf7b14d45010a
ToppCellcontrol-B_naive|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TMEM156 HHEX SP100 SPIB CD22 DSP CD79A

6.37e-08198797c012b8fbfa8bbc5014217f47acf9177470d8a65a
ToppCellCOVID-19_Severe-B_cell|World / disease group, cell group and cell class

TMEM156 TUT4 CD22 CLTRN CD79A LHX3

2.72e-071497969a9fcbf7e8a6811958f3fd2d36315e19ab2b1127
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TMEM156 HHEX TPRG1L SPIB CD22 CD79A

4.95e-0716579683095377aedf960c05baa523869bdbd2b0a05f2d
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

HHEX SPIB CD22 DSP CLTRN CD79A

6.10e-07171796c3e3ea09c73050372314a89b282e36ba5f339d73
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIB CD22 CD79A LRP1B DNAH9 HYDIN

6.98e-07175796887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIB CD22 CD79A LRP1B DNAH9 HYDIN

7.22e-07176796c6484334187f64cd00cd35e77d8ae436556b4260
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-B_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SPIB CD22 DSP CD79A

9.35e-0718479612cbb6d5edc3c0a896d080ca990af57dbb6c9960
ToppCellBLOOD--(2)_Naive_B_cells| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TMEM156 HHEX SPIB CD22 DSP CD79A

9.96e-071867962e55a3892459152fc4a3a7834ccbf5d71b65d29a
ToppCellremission-B_memory|World / disease stage, cell group and cell class

TMEM156 HHEX SPIB CD22 CD79A KAT2A

1.13e-06190796c3f55f752e47b5a71e111367cdbed4a39ab5cb21
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-naive_B_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TMEM156 SP100 TUT4 SPIB CD22 CD79A

1.16e-06191796a073d58154c801ec499fd969f42b7f1ee7f15d79
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HHEX SP100 SPIB CD22 DSP CD79A

1.16e-06191796b374676ac90572d65895052d46469906e2b6fd93
ToppCell10x5'-bone_marrow-Lymphocytic_B-Naive_B_cells|bone_marrow / Manually curated celltypes from each tissue

TMEM156 HHEX SPIB CD22 DSP CD79A

1.20e-06192796fa99243ff028498c6a67d207a93e02c48e69cd42
ToppCellnormal-na-Lymphocytic_B-B_cell-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SP100 SPIB CD22 CD79A

1.24e-061937964fbf559771c367a6f5a03e0a5ef33366c118ddbf
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-11|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMEM156 HHEX SPIB CD22 DSP CD79A

1.24e-06193796cf4ba50aa4a00d1ba22fc7626d49a4104377d5d9
ToppCellnormal-na-Lymphocytic_B-B_cell|normal / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SP100 SPIB CD22 CD79A

1.24e-061937962fd1cc050c775360cd53872fd405cf78288d7c4d
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_B-Naive_B_cells|lymph-node_spleen / Manually curated celltypes from each tissue

HHEX SP100 SPIB CD22 DSP CD79A

1.24e-06193796eb497d62a45ad77b2578b03a84cb3edc83207be5
ToppCellnormal-na-Lymphocytic_B|normal / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SP100 SPIB CD22 CD79A

1.24e-061937965fe436b8da06c537b61d18aba8a24b0c8b1895bb
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TMEM156 HHEX SPIB CD22 CD79A KAT2A

1.24e-06193796de0213f2105b814f38ffbfd004ea7603230eed68
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-B_naive|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SPIB CD22 DSP CD79A

1.24e-06193796d0d0835304647758e6ad4348402a4f76a76137a0
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B-Naive_B_cells|lymph-node_spleen / Manually curated celltypes from each tissue

HHEX SP100 SPIB CD22 DSP CD79A

1.27e-0619479620967afbadb3cf80ba9f4d7ebda4e64389252e70
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-B_naive-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SPIB CD22 DSP CD79A

1.27e-06194796a778b5d1f7661c29dc8d894827891c1036255749
ToppCellCOVID-19_Moderate-B_naive|COVID-19_Moderate / disease group, cell group and cell class

TMEM156 HHEX SPIB CD22 DSP CD79A

1.27e-061947968c41a37467bfd4966ecd09dde68c543dc01b6ad0
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMEM156 HHEX SPIB CD22 DSP CD79A

1.27e-0619479682753b90ca3b563275c41b6040ebbcd99b185e24
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-memory_B_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TMEM156 HHEX SP100 SPIB CD22 CD79A

1.27e-06194796f0c113edb706d53792892115b67277a285219942
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 HHEX SP100 SPIB CD22 CD79A

1.31e-061957969355dd84350f98cb33466acdfd90a39c50c9e39f
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TMEM156 HHEX SPIB CD22 DSP CD79A

1.31e-061957968f5a664dd65c38afe23c6acd0a9c22ba4fd347ed
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

TMEM156 HHEX SPIB CD22 DSP CD79A

1.31e-06195796e830f0c545be87a1056a4505bdf6845e5ac7750d
ToppCellcontrol-B_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TMEM156 HHEX SPIB CD22 DSP CD79A

1.39e-06197796559650fb53f18ecae4cfaa8221e978ae3fb63e06
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TMEM156 HHEX SPIB CD22 CD79A LHX3

1.39e-06197796da61afba697ec49ca86e062d35a825280da558ac
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HHEX CDX4 CENPA ASPM PRSS23 ITGA5

1.43e-06198796604fb20ca1aaf8f07067a8e1593a30ba335891f7
ToppCellmLN-B_cell|mLN / Region, Cell class and subclass

TMEM156 HHEX SP100 SPIB CD22 CD79A

1.48e-0619979699c7d157a1e819ff86c526ffd9b7036ed3514cae
ToppCellmLN-(2)_B_cell|mLN / shred on region, Cell_type, and subtype

TMEM156 HHEX SP100 SPIB CD22 CD79A

1.48e-061997969464c8c72a6b2e14a27b413cc1f5d64550212776
ToppCellMS-IIF-Lymphocyte-B-B_naive|IIF / Disease, condition lineage and cell class

TMEM156 HHEX SP100 SPIB CD22 CD79A

1.52e-0620079615f429137b2a3906724118085fcd59750cd767c7
ToppCellmLN-(2)_B_cell-(23)_Follicular_B_cell|mLN / shred on region, Cell_type, and subtype

TMEM156 HHEX SP100 SPIB CD22 CD79A

1.52e-06200796659b49eeeb3e96b0a52663e60336ca4d76c83cfc
ToppCellmLN-B_cell-Follicular_B_cell|mLN / Region, Cell class and subclass

TMEM156 HHEX SP100 SPIB CD22 CD79A

1.52e-062007967f5dbd06f8643230dba45d6fa0258a13cb71f681
ToppCellsevere-B_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TMEM156 SPIB CD22 DSP CD79A GNAS

1.52e-062007960e86f52b6e146d9bbc728d8fb176fc2b53696558
ToppCellmild-B_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TMEM156 SP100 SPIB CD22 DSP CD79A

1.52e-06200796222789b897e2a683bbfd1d00b6fd8705015d90df
ToppCellMS-IIF-Lymphocyte-B|IIF / Disease, condition lineage and cell class

TMEM156 HHEX SP100 SPIB CD22 CD79A

1.52e-06200796a0f3362b7ddfc122e30e75fb541bb0b7d0321c72
ToppCellsevere-B_naive|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TMEM156 HHEX SPIB CD22 DSP CD79A

1.52e-06200796306df1f498ac2188eaf9f2a8d002bb73bdb9642d
ToppCellmild-B_naive|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TMEM156 HHEX SPIB CD22 DSP CD79A

1.52e-06200796d0467cab6a42bf780aa49046bf3231ca161dc144
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_memory-B_activate-7|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMEM156 SPIB TENM3 CD22 CD79A

4.91e-06139795693ca81f5831b63fe6148ac755631e09f67d0ebf
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SP100 SPIB CD22 CD79A TESPA1

6.67e-06148795b78dac56b333bf901136ccafb0999f345e978f51
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-9|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HHEX SPIB CD22 DSP CD79A

7.12e-06150795d9931507257c64ead4a53786e6822f51962c6015
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SP100 SPIB CD22 CD79A TESPA1

7.35e-06151795ee56b88c56c3b6a5ec9644c43cae521ea0e05920
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SP100 SPIB CD22 CD79A TESPA1

7.35e-061517952c239b09970acbaa90c5ebe1097f453c516f868e
ToppCellCOVID-19_Severe-B_cell|COVID-19_Severe / disease group, cell group and cell class

TMEM156 CD22 CD79A LHX3 PRSS23

7.84e-06153795701a7d92ee7b22277c8462742a530347cc6f061a
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMEM156 SPIB CD22 DSP CD79A

8.09e-06154795020697ae8463b18f9b4270c404f52ce4c0e90135
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TUT4 SPIB CD22 DSP CD79A

9.74e-061607957ad065337ac802de52c15ee715f6b78a3eed0cef
ToppCellmild_COVID-19_(asymptomatic)-B_intermediate|World / disease group, cell group and cell class (v2)

TMEM156 SPIB CD22 CD79A RNF17

9.74e-061607956722934e153b72039c3c4308557d0ef879a30638
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-13|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HHEX SPIB CD22 DSP CD79A

1.03e-0516279528b3a6ae5519a267eefb70436d3190a387d027b9
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPIB CENPA CD22 ASPM CD79A

1.10e-05164795249d8f75a64bce7db52ce0c563f496b9edf602a6
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPIB CENPA CD22 ASPM CD79A

1.13e-05165795953c8242a81a39ade63ac8e5b34fe58575771746
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TUT4 SPIB CD22 DSP CD79A

1.13e-05165795fead3f2032f8fa5f7f0159a4434989b3d65debbb
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM156 HHEX SPIB CD22 CD79A

1.16e-05166795a8ba4d51e778634f8a7f47fa0d01a2019f774fb8
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-B_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM156 HHEX SPIB CD22 CD79A

1.16e-051667954906c85f52c3751166e296102d524a13b1f438f5
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM156 HHEX SPIB CD22 CD79A

1.16e-0516679504e32bd32165cdf316f2a8709c3662d55cd70391
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM156 HHEX SPIB CD22 CD79A

1.23e-051687950ecc6503ea249a4b13c42cfec2b024338f7e6080
ToppCelllymphoid-B_cell-Naive_B_cell|B_cell / Lineage, cell class and subclass

TMEM156 SPIB CD22 CD79A

1.26e-0580794dd2ecd244cd2cf770ada756ac96e34afc3301772
ToppCelldroplet-Kidney-nan-21m-Lymphocytic-CD45____B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 SPIB CD22 CD79A TESPA1

1.27e-05169795d44fc49056799dfc70a3c7d538c210d88ffded05
ToppCelldroplet-Kidney-nan-21m-Lymphocytic-B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 SPIB CD22 CD79A TESPA1

1.31e-0517079553fd50c9a27d47662fbcbd7e9e9837f72ac448c5
ToppCelldroplet-Pancreas-Endocrine-21m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 SPIB CD22 CD79A TESPA1

1.31e-051707956086d658a52a1961a1e293cbc3703ae8d309cd11
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SP100 TUT4 SPIB CD22 CD79A

1.34e-05171795656a9f407461dbf5c9c0bd234399e1fef6abce2a
ToppCellsevere_influenza-B_memory|World / disease group, cell group and cell class (v2)

TMEM156 SPIB CD22 CD79A KAT2A

1.38e-051727950ff38f9431cec73250c580a6010cb7891a3fe3f1
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMEM156 SPIB CD22 DSP CD79A

1.38e-0517279562ed3b70fa1f6c84ea80ff00f60d2562be292e9d
ToppCelldroplet-Marrow-nan-24m-Hematologic-erythroid_progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 SPIB CD22 CD79A PRSS23

1.38e-05172795910ec7794ea4000db4ef1e2c34e08dbc0243df2c
ToppCellfacs-Spleen-nan-24m-Lymphocytic-CD79a_B_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HHEX SPIB CD22 CLTRN CD79A

1.38e-051727950c6332a806ac75fffae6080f61965555c7f687f4
ToppCellcontrol-Lymphocytic-B_cells_2|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

HHEX SP100 SPIB CD22 CD79A

1.42e-0517379595af11b7d6c7dcd470943e5bdc56bed7a134e358
ToppCellASK428-Immune-B_cell|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

TMEM156 SPIB CD22 CD79A SNX13

1.46e-05174795b5a7a612a515736cf3489afd0f6ad2054d54526f
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_memory-B_memory-6|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMEM156 SPIB CD22 CD79A KAT2A

1.50e-05175795eaec7fda07a9537d067ca13b607a8ab201caa7c4
ToppCellNS-critical-d_07-13-Lymphoid-B_cell|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TMEM156 HHEX SPIB CD22 CD79A

1.59e-05177795d4db058c09012ec9fbde61277a9f86d9956de8fc
ToppCellNS-moderate-d_16-33-Lymphoid-B_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TMEM156 HHEX SPIB CD22 CD79A

1.59e-05177795320fd77c7c98e9305dcc34a168ec9d674539ed65
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-11|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HHEX SPIB CD22 CD79A CFAP44

1.59e-051777953535575686c9700ab72700aae6f2070ebbb50044
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-CD45____B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 TUT4 SPIB CD22 CD79A

1.63e-051787955a4f97d19265577cfdb3e53f9dc3a9a02cfcffa9
ToppCellLeuk-UTI-Lymphocyte-B-B_intermediate|Leuk-UTI / Disease, Lineage and Cell Type

TMEM156 SPIB CD22 CD79A RNF180

1.67e-0517979501933f6fa94d7032ed403a6cae6985cafa820043
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_memory-B_memory-0|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMEM156 HHEX SPIB CD22 CD79A

1.67e-05179795fce1ba53815145f6248d4e90aedca3dad84e33e4
ToppCellCOVID-19_Moderate-B_memory|World / disease group, cell group and cell class

TMEM156 SPIB CD22 CD79A KAT2A

1.72e-051807952f37187b866edb56410c2334b72713f2248dc335
ToppCelldroplet-Pancreas-Endocrine-21m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 SPIB CD22 CD79A TESPA1

1.72e-0518079583f9060dcf1d0ff8d2b2edc1841b2624b81c0eb3
ToppCellChildren_(3_yrs)-Immune-B_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TMEM156 SP100 SPIB CD22 CD79A

1.72e-0518079540a12eb852373ae3d7c8d9bca376b0ae99f724b3
ToppCell3'_v3-Lung-Lymphocytic_B|Lung / Manually curated celltypes from each tissue

TMEM156 SPIB CD22 DSP CD79A

1.72e-05180795237a2130a3f48595dad2417539c21e44585962b8
ToppCellFetal_29-31_weeks-Immune-B_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TMEM156 SP100 SPIB CD22 CD79A

1.77e-0518179557f20341c3e9f9f6ed5b6c181605ad35bae91414
ToppCellcontrol-Lymphoid-B_cell|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TMEM156 HHEX SPIB CD22 CD79A

1.77e-05181795e414303bb90e5fe7b667c2acf9a50f8694b90e54
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 TUT4 SPIB CD22 CD79A

1.77e-0518179546de8c18e4ec8dc9d07f7c8cc7b5f48b9c613aae
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-B_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TUT4 SPIB CD22 CD79A TESPA1

1.77e-05181795477c572c5c1efceee49732cc9e8b1dad68a7e6e5
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-B_cell-B_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TUT4 SPIB CD22 CD79A TESPA1

1.77e-05181795909280b44085d8e96fcd3cbcba6bff94badd41e8
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-1|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMEM156 HHEX SPIB CD22 CD79A

1.77e-051817956df40f86c569b6ecfc3137a68d1355b012dbf6bf
ToppCellCOVID-19_Moderate-B_memory|COVID-19_Moderate / disease group, cell group and cell class

TMEM156 SPIB CD22 CD79A KAT2A

1.81e-05182795bbdbef62389ac062118cc0c7979686393399f2c8
ToppCelldroplet-Pancreas-Endocrine-21m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 SPIB CD22 CD79A TESPA1

1.81e-05182795cf32603ad9b9882b0bb873327d58b50dd26a5bd3
ToppCellnormal-na-Lymphocytic_B-B_mem-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

TMEM156 SP100 SPIB CD22 CD79A

1.81e-05182795ee36ea6cb9a5a08aeb83f2b7a249255f0b1a9870
ToppCellfacs-Heart-LV-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 CD22 TOPBP1 CD79A TESPA1

1.81e-051827956dff753d65ba45db81f3cc0c9f59e1779d490955
ToppCelldroplet-Pancreas-Endocrine-21m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 SPIB CD22 CD79A TESPA1

1.81e-0518279571cfd0b6d464e3e1b1cca34f423abdf699cda48a
ToppCellNS-control-d_0-4-Lymphoid-B_cell|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TMEM156 HHEX SPIB CD22 CD79A

1.81e-051827954b9b55154a79992112c1c467e8752c3cdbb541d9
ToppCellInt-URO-Lymphocyte-B-B_naive|Int-URO / Disease, Lineage and Cell Type

TMEM156 SPIB CD22 DSP CD79A

1.81e-05182795af7482c63e87a53cf686200a8f4d5b9749235dcd
DrugGriseofulvin [126-07-8]; Down 200; 11.2uM; HL60; HT_HG-U133A

DDX54 PAN2 CCDC85C UGGT2 PLD1 USF2 CDC14A BMP15

2.94e-071937782332_DN
DrugBemegride [64-65-3]; Down 200; 25.8uM; PC3; HT_HG-U133A

SP100 URB1 TENM3 CCDC85C SFI1 PLD1 ARHGEF4 GNAS

3.58e-071987786668_DN
DrugClomipramine hydrochloride [17321-77-6]; Up 200; 11.4uM; PC3; HT_HG-U133A

SP100 SFI1 KAT2A ARHGEF4 MMP14 TESPA1 HESX1

3.84e-061917774487_UP
Drug(R)-Propranolol hydrochloride [13071-11-9]; Up 200; 13.6uM; MCF7; HT_HG-U133A

CD22 SPTAN1 CCDC85C SFI1 ARHGEF4 GNAS CDC14A

4.40e-061957773553_UP
DrugEthynodiol diacetate [297-76-7]; Down 200; 10.4uM; PC3; HT_HG-U133A

URB1 TENM3 SPTAN1 ARHGEF4 CDC14A TESPA1 BMP15

4.55e-061967776678_DN
Drug2-propylpentanoic acid; Down 200; 1000uM; ssMCF7; HG-U133A

DRP2 CCDC85C CD79A PRSS23 HMX1 USF2 MMP19

4.70e-06197777497_DN
Drug1,1-dimethylbiguanide hydrochloride; Up 200; 10uM; MCF7; HG-U133A

ERCC6 SFI1 PLD1 SNX11 HMX1 ITGA5 MMP14

4.86e-061987772_UP
DrugAC1NE3MZ

HHEX CD22 FADD CARD16 LNPK

1.44e-0591775CID004636047
Drugmonastrol; Down 200; 100uM; MCF7; HG-U133A

CD22 MRPL19 KAT2A MED13L USF2 KIF1C

5.38e-05196776627_DN
DrugOxamniquine [21738-42-1]; Down 200; 14.4uM; HL60; HT_HG-U133A

TMEM156 ARL3 ERCC6 PLD1 USF2 CDC14A

5.38e-051967762924_DN
Drug2-propylpentanoic acid; Up 200; 200uM; HL60; HT_HG-U133A

DSP SPTAN1 PRSS23 MMP19 CDC14A HESX1

5.53e-051977762674_UP
Drug(d,l)-Tetrahydroberberine [522-97-4]; Up 200; 11.8uM; PC3; HT_HG-U133A

TUT4 DRP2 SPTAN1 CD79A HESX1 KIF1C

5.53e-051977764020_UP
DrugPilocarpine nitrate [148-72-1]; Down 200; 14.8uM; MCF7; HT_HG-U133A

SP100 TUT4 ERCC6 SPTAN1 USF2 KIF1C

5.53e-051977763300_DN
DrugHomatropine hydrobromide (R,S) [51-56-9]; Down 200; 11.2uM; MCF7; HT_HG-U133A

HHEX SPTAN1 KAT2A USF2 MMP14 MMP19

5.53e-051977765477_DN
DrugHydrochlorothiazide [58-93-5]; Down 200; 13.4uM; MCF7; HT_HG-U133A

SP100 TUT4 SPTAN1 SFI1 ARHGEF4 CDC14A

5.69e-051987764970_DN
DrugEthamivan [304-84-7]; Down 200; 18uM; MCF7; HT_HG-U133A

URB1 TENM3 SPTAN1 CCDC85C USF2 MMP19

5.69e-051987762879_DN
DrugMeclofenamic acid sodium salt monohydrate [6385-02-0]; Up 200; 11.8uM; PC3; HT_HG-U133A

SP100 SPTAN1 MED13L CDC14A BMP15 KIF1C

5.69e-051987762128_UP
DrugEstrone [53-16-7]; Down 200; 14.8uM; MCF7; HT_HG-U133A

SPTAN1 SFI1 ITGA5 USF2 CFAP44 BMP15

5.85e-051997766448_DN
DrugEtidronic acid, disodium salt [7414-83-7]; Down 200; 16uM; PC3; HT_HG-U133A

URB1 PLD1 ARHGEF4 USF2 MMP14 KIF1C

5.85e-051997764564_DN
DrugTheophylline monohydrate [5967-84-0]; Down 200; 20.2uM; HL60; HT_HG-U133A

URB1 SPTAN1 DDX54 CCDC85C CDC14A SNX13

5.85e-051997762986_DN
DrugHesperidin [520-26-3]; Up 200; 6.6uM; MCF7; HT_HG-U133A

SPIB TENM3 SPTAN1 CCDC85C SFI1 LHX3

6.02e-052007762648_UP
DiseaseAbnormality of the cerebellum

LHX4 LNPK

6.34e-055752C1866129
DiseaseCombined pituitary hormone deficiencies, genetic form

LHX4 LHX3

6.34e-055752cv:C4273747
DiseasePituitary Hormone Deficiency, Combined, 1

LHX4 HESX1

9.50e-056752C2751608
Diseasehypopituitarism (implicated_via_orthology)

LHX3 HESX1

9.50e-056752DOID:9406 (implicated_via_orthology)
Diseasepanhypopituitarism (is_implicated_in)

LHX4 LHX3

1.33e-047752DOID:9410 (is_implicated_in)
DiseasePituitary stalk interruption syndrome

LHX4 HESX1

1.33e-047752C4053775
DiseaseMicrophthalmos

ERCC6 HMX1

3.45e-0411752C0026010
Diseaseascending aortic diameter

CEP120 NRBF2 MED13L HYDIN

4.54e-04140754EFO_0021787
DiseaseSclerocystic Ovaries

DDX54 ASPM GNAS BMP15

5.05e-04144754C1136382
DiseasePolycystic Ovary Syndrome

DDX54 ASPM GNAS BMP15

5.05e-04144754C0032460
DiseaseCraniofacial Abnormalities

ERCC6 ALX1 FADD HMX1

6.83e-04156754C0376634
Diseasehydrocephalus (implicated_via_orthology)

CCDC85C HYDIN

1.06e-0319752DOID:10908 (implicated_via_orthology)
DiseaseJoubert syndrome 1

ARL3 CEP120

1.30e-0321752C4551568
DiseaseSensorineural Hearing Loss (disorder)

FADD LHX3

1.56e-0323752C0018784

Protein segments in the cluster

PeptideGeneStartEntry
KWRKRERYGQIQQAK

ALX1

186

Q15699
EQRDPQLRRKQQRWK

GNAS

286

P84996
LERRIVGQYKLNWKN

FAM200B

276

P0CF97
KIWFQNRRAKERKIN

CDX2

231

Q99626
GLSERQVKIWFQNRR

CDX4

211

O14627
QVKIWFQNRRAKERK

CDX4

216

O14627
LQKNNKDRFCQLLWR

EIF3B

691

P55884
QKLFQLESKNRWLRQ

ANKRD30B

1301

Q9BXX2
FLGSLKRQKRQLWDR

ECRG4

61

Q9H1Z8
LWVQGDIFRSKLKNR

CDC14A

331

Q9UNH5
PEQKQRWLKAFARER

ARHGEF4

591

Q9NR80
FKLNVWDIGGQRKIR

ARL3

61

P36405
KNLVFAQRWGIRKGI

ABCB11

306

O95342
TLLLFRKRWQNEKLG

CD79A

161

P11912
RNVGQWEKRKQLLLA

HSD11B2

271

P80365
QQKLNKEWRERRKQL

CFAP44

1666

Q96MT7
YKQRLRRWNKLRLQD

ERCC6

461

Q03468
VIQKYWRRVLAQRKL

ASPM

1321

Q8IZT6
NVRRKRYAIQGLKWQ

MMP14

106

P50281
KANRRVLLWLVGLQN

KAT2A

511

Q92830
RLKGKPQERQRQWIQ

NIBAN2

256

Q96TA1
KGNLARLIQRWNRFI

PAN2

606

Q504Q3
IKIENAWGIRIYQKR

LRP1B

451

Q9NZR2
RLLAQPNKRFKIWQD

MED13L

671

Q71F56
QNRRAKWRRLKQENP

HHEX

186

Q03014
QNRRNKWKRQLAAEL

HMX3

276

A6NHT5
QQRFWNNKGHRILRL

BMP15

191

O95972
QKGRKLAREWQRFGR

CCDC85C

96

A6NKD9
QNLTRGRQQLKWDRK

DDX54

721

Q8TDD1
KVYWRLNQQLRVEKG

MMP19

446

Q99542
FQNRRNKWKRQLAAE

HMX1

251

Q9NP08
RIQIWFQNRRAKLKR

HESX1

151

Q9UBX0
RGRLRWLKQEQLRLQ

KIF1C

936

O43896
VQVWFQNRRAKEKRL

LHX3

201

Q9UBR4
VQVWFQNRRAKEKRL

LHX4

201

Q969G2
KNGLNLLRRLWVVKF

GCN1

1121

Q92616
KQLLLIQERWKRAQR

NRBF2

66

Q96F24
LQLDWQKQKGGVRRA

ITGA5

546

P08648
GLKLQWRDKIRLNNA

MLXIP

151

Q9HAP2
FKLINKGRRIQQLFW

HYDIN

931

Q4G0P3
SRRRQGWLKEIRKLQ

CENPA

41

P49450
QQWGRALKELARLKQ

CEP120

846

Q8N960
FRLWDLEKQIKQLRN

DSP

876

P15924
DNVGKDWRRLARQLK

FADD

106

Q13158
NCWKFFIDRIRRQLK

DNAH9

2936

Q9NYC9
FLEDAQRIWKQKLQR

CARD16

116

Q5EG05
LKLQRRWKRTQSQQG

CD22

706

P20273
NRILQGELRRLKWQH

DRP2

796

Q13474
LAQLKAWVRKLQRRG

PTX4

101

Q96A99
KQRRRERWLQKQGKY

RNF180

386

Q86T96
DLKERNQWLRRNIKN

SNX13

796

Q9Y5W8
KAWLEYLQVRRVKRQ

SFI1

291

A8K8P3
REFVWLRKQLQRNAG

SNX11

61

Q9Y5W9
GNRWRLDCILKRKAQ

PLD1

396

Q13393
VWKGYLQRKRTQQDR

IQCA1L

216

A6NCM1
KRQQQKWERKIIGIF

PRSS23

326

O95084
TRVLIWNIRRNKNGK

MORC4

216

Q8TE76
VQVWFQNRRAKCRKQ

SHOX

161

O15266
ELLARRWGQQKGNRK

SPIB

206

Q01892
KESKGRQVRRWQALL

SYT14P1

171

Q58G82
KWVFGVLRQGIRDKQ

URB1

1786

O60287
LILSGIWQRRRKNKE

CLTRN

161

Q9HBJ8
KRWERPNFNIKGIRF

MRPL19

231

P49406
VKIQDKNQWRRGQII

RNF17

971

Q9BXT8
TIRKILEGQRRVQKW

TMEM156

231

Q8N614
LEQRKEPWNARRQKT

ZNF727

56

A8MUV8
LRLKGSIFRNEWQNK

ZNF540

111

Q8NDQ6
RARPWRKNLQEVFGK

ZDHHC22

226

Q8N966
RKNLQEVFGKRWLLG

ZDHHC22

231

Q8N966
LRNNRRPKKWSVVNF

ZSCAN5DP

116

P0CG00
AWQRLKGLALQRQGK

SPTAN1

236

Q13813
NKREGFGIRIQWDKQ

TPRG1L

156

Q5T0D9
LNNKVQKKRWQQRGR

SP100

561

P23497
LVEWRFRKEQAQGKV

TENM3

1746

Q9P273
RRRDKINNWIVQLSK

USF2

246

Q15853
QQKWKQSVDRPELRR

TESPA1

461

A2RU30
RQQTERQRIIWGYKI

UGGT2

1301

Q9NYU1
AVLWLRNNRDKFKQR

SMC5

466

Q8IY18
QDILTRENKNWPKRR

TUT4

656

Q5TAX3
RWRKKIQQRQESGIV

TOPBP1

1376

Q92547
FREKNQRLQKLWVGR

LNPK

31

Q9C0E8