Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	tubulin binding	DST DCDC1 SMC3 MACF1 RABGAP1 GOLGA8A VBP1	1.47e-04	428	54	7	GO:0015631
GeneOntologyBiologicalProcess	peptidyl-serine modification	FNIP2 TLK2 MET LATS1 GALNT3 ROCK1 ATM CDC7	1.94e-06	319	55	8	GO:0018209
GeneOntologyBiologicalProcess	regulation of cellular component biogenesis	FNIP2 MET LATS1 VPS35 DOCK10 PSMC5 LMOD1 MACF1 ROCK1 RABGAP1 ATM ODF2 TRIM37	1.09e-05	1189	55	13	GO:0044087
GeneOntologyBiologicalProcess	mitotic cell cycle process	CUL2 MET LATS1 DCDC1 SMC3 CCNB3 ROCK1 ATM CEP126 GOLGA8A CDC7	1.30e-05	854	55	11	GO:1903047
GeneOntologyBiologicalProcess	peptidyl-serine phosphorylation	FNIP2 TLK2 MET LATS1 ROCK1 ATM CDC7	1.66e-05	307	55	7	GO:0018105
GeneOntologyBiologicalProcess	microtubule-based process	MET DST SMC3 MACF1 ROCK1 CEP126 ODF2 GOLGA8A DNAH8 TRIM37 VBP1 CCDC40	1.76e-05	1058	55	12	GO:0007017
GeneOntologyBiologicalProcess	cell cycle process	TLK2 CUL2 MET LATS1 DCDC1 SMC3 CCNB3 ROCK1 ATM CEP126 ODF2 GOLGA8A TRIM37 CDC7	1.78e-05	1441	55	14	GO:0022402
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	MET DST SMC3 ROCK1 CEP126 ODF2 GOLGA8A DNAH8 TRIM37 CCDC40	1.78e-05	720	55	10	GO:0000226
GeneOntologyBiologicalProcess	negative regulation of protein metabolic process	TLK2 MET SFRP5 LATS1 GLG1 VPS35 ROCK1 CDYL PPEF2 RECK VBP1 OPHN1	2.33e-05	1088	55	12	GO:0051248
GeneOntologyBiologicalProcess	mitotic cell cycle	CUL2 MET LATS1 DCDC1 SMC3 CCNB3 ROCK1 ATM CEP126 GOLGA8A CDC7	6.27e-05	1014	55	11	GO:0000278
GeneOntologyBiologicalProcess	peptidyl-amino acid modification	FNIP2 TLK2 MET RANBP2 LATS1 GALNT3 ROCK1 ATM PPEF2 CDC7	2.26e-04	976	55	10	GO:0018193
GeneOntologyCellularComponent	microtubule organizing center	FNIP2 CCDC112 LATS1 CCNB3 GLG1 ANKS1B ROCK1 RABGAP1 ATM CEP126 ODF2	2.26e-05	919	55	11	GO:0005815
GeneOntologyCellularComponent	centrosome	FNIP2 CCDC112 LATS1 CCNB3 ANKS1B RABGAP1 ATM CEP126 ODF2	1.66e-04	770	55	9	GO:0005813
GeneOntologyCellularComponent	spindle	LATS1 DCDC1 SMC3 ATM ODF2 GOLGA8A CDC7	2.25e-04	471	55	7	GO:0005819
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	TLK2 DST DCDC1 IFFO2 LMOD1 MACF1 ODF2 GOLGA8A DNAH8	5.18e-04	899	55	9	GO:0099513
GeneOntologyCellularComponent	perinuclear region of cytoplasm	TLK2 RANBP2 DST GALNT3 UPF2 VPS35 GOLGA8A TRIM37 LAPTM5	6.82e-04	934	55	9	GO:0048471
GeneOntologyCellularComponent	supramolecular fiber	TLK2 MTMR12 DST DCDC1 IFFO2 LMOD1 MACF1 ODF2 GOLGA8A DNAH8	8.99e-04	1179	55	10	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	TLK2 MTMR12 DST DCDC1 IFFO2 LMOD1 MACF1 ODF2 GOLGA8A DNAH8	9.46e-04	1187	55	10	GO:0099081
GeneOntologyCellularComponent	postsynapse	MET DST VPS35 ANKS1B DOCK10 PSMC5 MACF1 OPHN1 GABRR3	1.25e-03	1018	55	9	GO:0098794
GeneOntologyCellularComponent	DNA repair complex	ATM PHF21A	1.66e-03	23	55	2	GO:1990391
GeneOntologyCellularComponent	inclusion body	RANBP2 PSMC5 TRIM37	1.72e-03	90	55	3	GO:0016234
GeneOntologyCellularComponent	mitotic spindle	DCDC1 SMC3 GOLGA8A CDC7	1.93e-03	201	55	4	GO:0072686
GeneOntologyCellularComponent	spindle pole	LATS1 SMC3 ODF2 GOLGA8A	2.07e-03	205	55	4	GO:0000922
Domain	-	RANBP2 MTMR12 ANKS1B DOCK10 ROCK1 RABGAP1 OPHN1	8.74e-05	391	51	7	2.30.29.30
Domain	Kinase-like_dom	TLK2 MET LATS1 DST MACF1 ROCK1 ATM CDC7	1.01e-04	542	51	8	IPR011009
Domain	-	DST MACF1	1.09e-04	6	51	2	3.90.1290.10
Domain	GAR	DST MACF1	1.09e-04	6	51	2	PS51460
Domain	-	DST MACF1	1.09e-04	6	51	2	3.30.920.20
Domain	GAS_dom	DST MACF1	1.09e-04	6	51	2	IPR003108
Domain	GAS2	DST MACF1	1.09e-04	6	51	2	PF02187
Domain	GAS2	DST MACF1	1.09e-04	6	51	2	SM00243
Domain	PH_dom-like	RANBP2 MTMR12 ANKS1B DOCK10 ROCK1 RABGAP1 OPHN1	1.49e-04	426	51	7	IPR011993
Domain	Plectin_repeat	DST MACF1	1.52e-04	7	51	2	IPR001101
Domain	Plectin	DST MACF1	1.52e-04	7	51	2	PF00681
Domain	PLEC	DST MACF1	1.52e-04	7	51	2	SM00250
Domain	EF-hand_7	DST MACF1 PPEF2	1.62e-03	85	51	3	PF13499
Domain	Actinin_actin-bd_CS	DST MACF1	1.78e-03	23	51	2	IPR001589
Domain	Spectrin	DST MACF1	1.78e-03	23	51	2	PF00435
Domain	ACTININ_2	DST MACF1	1.78e-03	23	51	2	PS00020
Domain	ACTININ_1	DST MACF1	1.78e-03	23	51	2	PS00019
Domain	PID	ANKS1B RABGAP1	2.64e-03	28	51	2	PF00640
Domain	Spectrin_repeat	DST MACF1	2.83e-03	29	51	2	IPR002017
Domain	Spectrin/alpha-actinin	DST MACF1	3.44e-03	32	51	2	IPR018159
Domain	PID	ANKS1B RABGAP1	3.44e-03	32	51	2	PS01179
Domain	SPEC	DST MACF1	3.44e-03	32	51	2	SM00150
Domain	Pkinase_C	LATS1 ROCK1	4.58e-03	37	51	2	IPR017892
Domain	PTB	ANKS1B RABGAP1	5.34e-03	40	51	2	SM00462
Domain	PTB/PI_dom	ANKS1B RABGAP1	5.60e-03	41	51	2	IPR006020
Domain	Pkinase_C	LATS1 ROCK1	5.87e-03	42	51	2	PF00433
Domain	PROTEIN_KINASE_ATP	TLK2 MET LATS1 ROCK1 CDC7	8.14e-03	459	51	5	PS00107
Domain	EF-hand_1	DST MACF1 PPEF2	8.27e-03	152	51	3	PF00036
Domain	EFh	DST MACF1 PPEF2	9.19e-03	158	51	3	SM00054
Domain	AGC-kinase_C	LATS1 ROCK1	1.02e-02	56	51	2	IPR000961
Domain	AGC_KINASE_CTER	LATS1 ROCK1	1.02e-02	56	51	2	PS51285
Domain	S_TK_X	LATS1 ROCK1	1.02e-02	56	51	2	SM00133
Domain	Prot_kinase_dom	TLK2 MET LATS1 ROCK1 CDC7	1.05e-02	489	51	5	IPR000719
Pubmed	Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function.	ROCK1 OPHN1	2.64e-06	2	57	2	27160703
Pubmed	Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.	CD8B CD8B2	2.64e-06	2	57	2	5558567
Pubmed	ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition.	ATM CDC7	2.64e-06	2	57	2	32877678
Pubmed	Increased MACC1 expression indicates a poor prognosis independent of MET expression in gastric adenocarcinoma.	MET MACC1	2.64e-06	2	57	2	26719224
Pubmed	Cloning and modeling of CD8 beta in the amphibian ambystoma Mexicanum. Evolutionary conserved structures for interactions with major histocompatibility complex (MHC) class I molecules.	CD8B CD8B2	2.64e-06	2	57	2	12034498
Pubmed	MACC1 controls Met: what a difference an Sp1 site makes.	MET MACC1	2.64e-06	2	57	2	19556890
Pubmed	Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.	DST MACF1	2.64e-06	2	57	2	11002341
Pubmed	MACC1 is related to colorectal cancer initiation and early-stage invasive growth.	MET MACC1	2.64e-06	2	57	2	24124150
Pubmed	MiR-1 downregulation cooperates with MACC1 in promoting MET overexpression in human colon cancer.	MET MACC1	2.64e-06	2	57	2	22179665
Pubmed	Molecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T-cell receptor variable and joining regions.	CD8B CD8B2	2.64e-06	2	57	2	3035575
Pubmed	Molecular characterization of the murine cytotoxic T-cell membrane glycoprotein Ly-3 (CD8).	CD8B CD8B2	2.64e-06	2	57	2	3498943
Pubmed	An immunological role for the CD8 beta-chain.	CD8B CD8B2	2.64e-06	2	57	2	1534146
Pubmed	Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy.	MET MACC1	2.64e-06	2	57	2	22493396
Pubmed	Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3.	SMC3 ATM	2.64e-06	2	57	2	18442975
Pubmed	ROCK I Has More Accurate Prognostic Value than MET in Predicting Patient Survival in Colorectal Cancer.	MET ROCK1	2.64e-06	2	57	2	26026086
Pubmed	Requirement for CD8 beta chain in positive selection of CD8-lineage T cells.	CD8B CD8B2	2.64e-06	2	57	2	8108731
Pubmed	Prognostic value and clinical pathology of MACC-1 and c-MET expression in gastric carcinoma.	MET MACC1	2.64e-06	2	57	2	23812675
Pubmed	Duality of the murine CD8 compartment.	CD8B CD8B2	2.64e-06	2	57	2	24594598
Pubmed	Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain.	CD8B CD8B2	2.64e-06	2	57	2	7889415
Pubmed	Murine Ly-3 restriction fragment length polymorphism and transcript size differences.	CD8B CD8B2	2.64e-06	2	57	2	2576243
Pubmed	AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas.	CD8B CD8B2	2.64e-06	2	57	2	3025647
Pubmed	Gene transfer of the Ly-3 chain gene of the mouse CD8 molecular complex: co-transfer with the Ly-2 polypeptide gene results in detectable cell surface expression of the Ly-3 antigenic determinants.	CD8B CD8B2	2.64e-06	2	57	2	2452747
Pubmed	Distinct methylation states of the CD8 beta gene in peripheral T cells and intraepithelial lymphocytes.	CD8B CD8B2	2.64e-06	2	57	2	9233619
Pubmed	Stalk region of beta-chain enhances the coreceptor function of CD8.	CD8B CD8B2	2.64e-06	2	57	2	12847256
Pubmed	The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development.	CD8B CD8B2	2.64e-06	2	57	2	9647223
Pubmed	The IB-peptide marker and the Ly-3 surface alloantigen: structural studies of a V kappa-region polymorphism and a T-cell marker determined by linked genes.	CD8B CD8B2	2.64e-06	2	57	2	408079
Pubmed	Transcriptional diversity at the duplicated human CD8 beta loci.	CD8B CD8B2	2.64e-06	2	57	2	8436166
Pubmed	[Prognostic value of MACC1 and c-met expressions in non-small cell lung cancer].	MET MACC1	2.64e-06	2	57	2	22814258
Pubmed	Characterization of the mouse CD8 beta chain-encoding gene promoter region.	CD8B CD8B2	2.64e-06	2	57	2	8781121
Pubmed	Structure and expression of the Lyt-3a gene of C.AKR mice.	CD8B CD8B2	2.64e-06	2	57	2	3169881
Pubmed	Esr, a second locus in the house mouse controlling esterase-5.	CD8B CD8B2	2.64e-06	2	57	2	7103930
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RANBP2 MACC1 LATS1 DST VPS35 ANKS1B ANKRD30A MACF1 ATM ODF2 DNAH8 GSR	3.09e-06	1442	57	12	35575683
Pubmed	Mouse microsatellites from a flow-sorted 4:6 Robertsonian chromosome.	MET CD8B CD8B2	3.97e-06	19	57	3	1450512
Pubmed	A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6.	MET CD8B CD8B2	3.97e-06	19	57	3	8499946
Pubmed	Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression.	CD8B CD8B2	7.91e-06	3	57	2	3258885
Pubmed	Ly-36: a new mouse lymphocyte alloantigen defined by a Mus musculus molossinus-specific monoclonal antibody and controlled by a gene linked to Ly-2/3 region on chromosome 6.	CD8B CD8B2	7.91e-06	3	57	2	3378837
Pubmed	CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I.	CD8B CD8B2	7.91e-06	3	57	2	22081144
Pubmed	Recent duplication of the two human CD8 beta-chain genes.	CD8B CD8B2	7.91e-06	3	57	2	1541829
Pubmed	Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus.	CD8B CD8B2	7.91e-06	3	57	2	100557
Pubmed	Zinc is essential for binding of p56(lck) to CD4 and CD8alpha.	CD8B CD8B2	7.91e-06	3	57	2	9830036
Pubmed	ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.	MET ATM	7.91e-06	3	57	2	22660439
Pubmed	Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer.	CD8B CD8B2	7.91e-06	3	57	2	16356863
Pubmed	Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.	CD8B CD8B2	7.91e-06	3	57	2	4547628
Pubmed	Linkage of a 7S RNA sequence and kappa light chain genes in the mouse.	CD8B CD8B2	7.91e-06	3	57	2	2998983
Pubmed	Expression of the mouse Macf2 gene during inner ear development.	DST MACF1	7.91e-06	3	57	2	12399109
Pubmed	Molecular biology and function of CD4 and CD8.	CD8B CD8B2	7.91e-06	3	57	2	2493728
Pubmed	Interaction of the nuclear matrix-associated region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8a gene.	CD8B CD8B2	7.91e-06	3	57	2	9218488
Pubmed	A new mouse lymphocyte alloantigen (Ly-35) controlled by the Ly-2/3 region on chromosome 6.	CD8B CD8B2	7.91e-06	3	57	2	3346044
Pubmed	Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo.	CD8B CD8B2	7.91e-06	3	57	2	23311920
Pubmed	Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells.	CD8B CD8B2	7.91e-06	3	57	2	12810689
Pubmed	A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice.	CD8B CD8B2	7.91e-06	3	57	2	9126989
Pubmed	CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation.	CD8B CD8B2	7.91e-06	3	57	2	11754824
Pubmed	The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC.	MET MACC1	7.91e-06	3	57	2	35242498
Pubmed	The synthesis and processing of beta-glucuronidase in normal and egasyn deficient mouse kidney.	CD8B CD8B2	7.91e-06	3	57	2	7236294
Pubmed	Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations.	MET MACC1	7.91e-06	3	57	2	21447729
Pubmed	Constitutive CD8 expression drives innate CD8+ T-cell differentiation via induction of iNKT2 cells.	CD8B CD8B2	7.91e-06	3	57	2	31980555
Pubmed	An essential role for the stalk region of CD8 beta in the coreceptor function of CD8.	CD8B CD8B2	7.91e-06	3	57	2	19109142
Pubmed	Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse.	CD8B CD8B2	7.91e-06	3	57	2	9878266
Pubmed	Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position.	CD8B CD8B2	7.91e-06	3	57	2	19625641
Pubmed	The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I.	CD8B CD8B2	7.91e-06	3	57	2	18929574
Pubmed	Recombination between kappa chain genetic markers in the mouse.	CD8B CD8B2	7.91e-06	3	57	2	6437974
Pubmed	Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells.	CD8B CD8B2	7.91e-06	3	57	2	11131152
Pubmed	MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.	MET MACC1	7.91e-06	3	57	2	19098908
Pubmed	Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus.	CD8B CD8B2	7.91e-06	3	57	2	10795739
Pubmed	Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.	CD8B CD8B2	7.91e-06	3	57	2	8064243
Pubmed	Role of CD8+ T cells and lymphoid dendritic cells in protection from ocular herpes simplex virus 1 challenge in immunized mice.	CD8B CD8B2	7.91e-06	3	57	2	24807710
Pubmed	CD8beta knockout mice mount normal anti-viral CD8+ T cell responses--but why?	CD8B CD8B2	7.91e-06	3	57	2	19088062
Pubmed	CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR.	CD8B CD8B2	7.91e-06	3	57	2	17506031
Pubmed	Bop: a new T-cell-restricted gene located upstream of and opposite to mouse CD8b.	CD8B CD8B2	7.91e-06	3	57	2	7590968
Pubmed	Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding.	CD8B CD8B2	7.91e-06	3	57	2	11719190
Pubmed	Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage.	SMC3 ATM	7.91e-06	3	57	2	11877376
Pubmed	Genetic polymorphism at the mouse immunoglobulin J kappa locus (Igk-J) as demonstrated by Southern hybridization and nucleotide sequence analysis.	CD8B CD8B2	7.91e-06	3	57	2	2875941
Pubmed	Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement.	CD8B CD8B2	7.91e-06	3	57	2	14568922
Pubmed	The Bop gene adjacent to the mouse CD8b gene encodes distinct zinc-finger proteins expressed in CTLs and in muscle.	CD8B CD8B2	7.91e-06	3	57	2	9013956
Pubmed	The CD8beta ectodomain contributes to the augmented coreceptor function of CD8alphabeta heterodimers relative to CD8alphaalpha homodimers.	CD8B CD8B2	7.91e-06	3	57	2	9973530
Pubmed	Differential susceptibility of mouse Lyt-2 and Lyt-3 genes to negative regulation.	CD8B CD8B2	7.91e-06	3	57	2	8423051
Pubmed	Isolation and characterization of the mouse CD8 beta-chain (Ly-3) genes. Absence of an intervening sequence between V- and J-like gene segments.	CD8B CD8B2	7.91e-06	3	57	2	2784466
Pubmed	Analysis of HGF, MACC1, C-met and apoptosis-related genes in cervical carcinoma mice.	MET MACC1	7.91e-06	3	57	2	24469707
Pubmed	Isolation of P1 bacteriophage clones containing large contiguous segments of the human and mouse loci for the T-cell coreceptor molecule CD8.	CD8B CD8B2	7.91e-06	3	57	2	7710778
Pubmed	Mapping the binding site on CD8 beta for MHC class I reveals mutants with enhanced binding.	CD8B CD8B2	7.91e-06	3	57	2	16951356
Pubmed	von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step.	CUL2 VBP1	7.91e-06	3	57	2	17698809
Pubmed	Recombination between kappa chain genetic markers and the Lyt-3 locus.	CD8B CD8B2	7.91e-06	3	57	2	6411613
Pubmed	Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development.	CD8B CD8B2	7.91e-06	3	57	2	15661911
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	MTMR12 LATS1 DST SMC3 TTC1 CTTNBP2NL TRIM37	8.28e-06	446	57	7	24255178
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	CUL2 NLN RANBP2 GLG1 PSMC5 ROCK1 RABGAP1 PFKL TTC1 CTTNBP2NL VBP1	1.16e-05	1367	57	11	32687490
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	RANBP2 DST SMC3 VPS35 PSMC5 MACF1 PFKL TTC1 VBP1 GSR	1.57e-05	1149	57	10	35446349
Pubmed	Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction.	CD8B CD8B2	1.58e-05	4	57	2	12459555
Pubmed	MACC1 suppresses cell apoptosis in hepatocellular carcinoma by targeting the HGF/c-MET/AKT pathway.	MET MACC1	1.58e-05	4	57	2	25660117
Pubmed	CD8α dendritic cells drive establishment of HSV-1 latency.	CD8B CD8B2	1.58e-05	4	57	2	24695322
Pubmed	The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation.	CD8B CD8B2	1.58e-05	4	57	2	18523287
Pubmed	CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease.	CD8B CD8B2	1.58e-05	4	57	2	21115736
Pubmed	{gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells.	CD8B CD8B2	1.58e-05	4	57	2	16203967
Pubmed	cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.	CD8B CD8B2	1.58e-05	4	57	2	24297179
Pubmed	CD8 is needed for development of cytotoxic T cells but not helper T cells.	CD8B CD8B2	1.58e-05	4	57	2	1673361
Pubmed	ATM regulates a RASSF1A-dependent DNA damage response.	LATS1 ATM	1.58e-05	4	57	2	19962312
Pubmed	Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins.	DST MACF1	1.58e-05	4	57	2	8954775
Pubmed	Ly antigens associated with T cell recognition and effector function.	CD8B CD8B2	1.58e-05	4	57	2	6442265
Pubmed	T cell killing does not require the formation of a stable mature immunological synapse.	CD8B CD8B2	1.58e-05	4	57	2	15048111
Pubmed	CD3 delta establishes a functional link between the T cell receptor and CD8.	CD8B CD8B2	1.58e-05	4	57	2	12215456
Pubmed	Autoimmune diabetes-prone NOD mice express the Lyt2 alpha (Lyt2.1) and Lyt3 alpha (Lyt3.1) alleles of CD8.	CD8B CD8B2	1.58e-05	4	57	2	8537123
Interaction	DISC1 interactions	DST SMC3 MACF1 RABGAP1 CEP126 PFKL TRIM37 RECK	1.31e-05	429	52	8	int:DISC1
Interaction	MTNR1B interactions	DST SMC3 VPS35 MACF1 RECK	2.53e-05	135	52	5	int:MTNR1B
Interaction	LURAP1 interactions	CCDC112 DOCK10 IFFO2 TRIM37 PHF21A	2.71e-05	137	52	5	int:LURAP1
Cytoband	10p11.21	CUL2 ANKRD30A	2.55e-04	19	57	2	10p11.21
GeneFamily	EF-hand domain containing\|Plakins	DST MACF1	7.92e-05	8	31	2	939
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	TLK2 CUL2 RANBP2 DST UPF2 SMC3 MACF1 ROCK1 CDYL RABGAP1 TRIM37 PHF21A	1.64e-07	856	55	12	M4500
Coexpression	HALLMARK_MITOTIC_SPINDLE	LATS1 DST SMC3 ROCK1 RABGAP1 OPHN1	3.78e-06	199	55	6	M5893
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_UP	TLK2 CUL2 SMC3 VPS35 ROCK1 TTC1 CTTNBP2NL VBP1	1.27e-05	523	55	8	M12707
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_UP	TLK2 CUL2 SMC3 VPS35 ROCK1 TTC1 CTTNBP2NL VBP1	1.48e-05	534	55	8	MM1054
Coexpression	SHEN_SMARCA2_TARGETS_UP	CUL2 UPF2 SMC3 MACF1 ROCK1 RABGAP1 VBP1	3.09e-05	429	55	7	M29
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	TLK2 DST UPF2 CDYL RABGAP1 TRIM37 PHF21A	5.21e-05	466	55	7	M13522
Coexpression	MURARO_PANCREAS_DUCTAL_CELL	MET NLN MACC1 MTMR12 SFRP5 DST GALNT3 PAFAH2 MACF1 CTTNBP2NL LAPTM5	5.78e-05	1276	55	11	M39173
Coexpression	GSE28737_WT_VS_BCL6_KO_MARGINAL_ZONE_BCELL_DN	CCDC112 RANBP2 MTMR12 GALNT3 ROCK1	5.99e-05	198	55	5	M9346
Coexpression	BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING	RANBP2 DST LMOD1 CDYL ODF2 RECK CCDC40	8.73e-05	506	55	7	M253
Coexpression	WANG_TARGETS_OF_MLL_CBP_FUSION_UP	GLG1 DNAH8 LAPTM5	1.17e-04	45	55	3	M1440
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1	TLK2 RANBP2 DST UPF2 SMC3 ROCK1 CEP126 CCDC40	1.71e-05	469	52	8	Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	RANBP2 SMC3 PSMC5 ROCK1 ATM CEP126 ODF2 CCDC40	4.20e-05	532	52	8	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#5	TLK2 LATS1 MACF1 ROCK1 ODF2	9.10e-05	186	52	5	Facebase_RNAseq_e10.5_Mandibular Arch_500_K5
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder epithelial cells_emap-30875_top-relative-expression-ranked_1000	FNIP2 CCDC112 MET NLN MACC1 DST GALNT3 ADGRF4 CTTNBP2NL	1.04e-04	780	52	9	gudmap_developingLowerUrinaryTract_e13.5_bladder epithelial cells_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2	TLK2 RANBP2 LATS1 SMC3 ROCK1 ODF2	1.09e-04	311	52	6	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_1000_k-means-cluster#5	RANBP2 SMC3 ATM ODF2 CCDC40	1.40e-04	204	52	5	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_1000_K5
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	TLK2 UPF2 SMC3 ANKS1B MACF1 ROCK1 ATM CEP126 ODF2 TRIM37 VBP1 CCDC40	1.66e-04	1459	52	12	facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlas	facebase_RNAseq_e10.5_MandArch_2500_K1	TLK2 CCDC112 SMC3 MACF1 ROCK1 CEP126 ODF2 CTTNBP2NL VBP1 CCDC40 CDC7	1.71e-04	1241	52	11	facebase_RNAseq_e10.5_MandArch_2500_K1
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K3	TLK2 SMC3 ROCK1 CDYL ATM CEP126 ODF2 CTTNBP2NL VBP1 CCDC40 LAPTM5	1.85e-04	1252	52	11	facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500	TLK2 LATS1 DOCK10 MACF1 ROCK1 ODF2 CTTNBP2NL	1.87e-04	492	52	7	Facebase_RNAseq_e10.5_Mandibular Arch_500
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	TLK2 UPF2 SMC3 MACF1 ROCK1 ATM CEP126 ODF2 TRIM37 VBP1 CCDC40	1.91e-04	1257	52	11	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	RANBP2 DOCK10 MACF1 ATM GOLGA8A	1.71e-06	162	55	5	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD8B CD8B2 DOCK10 ATM GOLGA8A	3.28e-06	185	55	5	847257d232b9993cad50c814fd4ffeef52385295
ToppCell	Myeloid-B_(Activated_Macrophage)\|World / shred on cell class and cell subclass (v4)	FNIP2 DST DOCK10 GSR LAPTM5	3.37e-06	186	55	5	33d731a7883d75e4e7db83b641cdb1e9a39938bf
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	FNIP2 DST ROCK1 ATM GOLGA8A	3.46e-06	187	55	5	0099def970fbc828756fbf853eca2ce77b8cd342
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	ANKS1B DOCK10 LMOD1 MACF1 ROCK1	3.55e-06	188	55	5	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SFRP5 CD8B CD8B2 DOCK10 ATM	3.64e-06	189	55	5	e9df7ecd36bee1fedce23bb188c68a94fa60462c
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	ANKS1B DOCK10 LMOD1 MACF1 ROCK1	3.64e-06	189	55	5	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	RANBP2 DOCK10 MACF1 ATM GOLGA8A	3.93e-06	192	55	5	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST DOCK10 MACF1 CTTNBP2NL OPHN1	4.03e-06	193	55	5	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST DOCK10 MACF1 CTTNBP2NL OPHN1	4.03e-06	193	55	5	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST DOCK10 MACF1 CTTNBP2NL OPHN1	4.03e-06	193	55	5	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SFRP5 CD8B CD8B2 ATM GOLGA8A	4.03e-06	193	55	5	d371403b51281a6e37652fa8dc1b2dd81d2ab371
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SFRP5 CD8B CD8B2 ATM GOLGA8A	4.03e-06	193	55	5	6436d3bfce02d137b76e5c4c8b2fe27974c57c99
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SFRP5 CD8B CD8B2 ATM GOLGA8A	4.03e-06	193	55	5	3cde93bbfc1ae6fb586ae6b7aaa6ed8b5eee28a4
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SFRP5 CD8B CD8B2 ATM GOLGA8A	4.03e-06	193	55	5	d755dc6de4fbd4d8f5d8a88aac497e7b9e8b89de
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST DOCK10 MACF1 CTTNBP2NL OPHN1	4.03e-06	193	55	5	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	facs-Brain_Myeloid-Hippocampus\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST MACF1 CTTNBP2NL OPHN1 LAPTM5	4.24e-06	195	55	5	a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TLK2 MACF1 ROCK1 ATM GOLGA8A	4.79e-06	200	55	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	FNIP2 DST UPF2 MACF1	2.35e-05	135	55	4	b7a792a7c0c22d8b703509f134115f0e394d7de0
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	RANBP2 MACF1 ATM GOLGA8A	4.13e-05	156	55	4	1545169694f686d28648a68b552c2ae606599d66
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MET CD8B PPEF2 RECK	4.13e-05	156	55	4	7569cab30caafcb273e8ef0b73c9e1bf87076984
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD8B CD8B2 RECK CDC7	4.56e-05	160	55	4	1a9329d8183296f36928bd9e96f10db9f04ce326
ToppCell	Healthy_donor-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	SFRP5 CD8B CD8B2 ATM	4.67e-05	161	55	4	8a61395af33132783a0a37956c6f821aba5d3b1e
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	RANBP2 MACF1 ATM GOLGA8A	5.91e-05	171	55	4	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	LV-13._Vascular_Smooth_Muscle\|LV / Chamber and Cluster_Paper	DOCK10 LMOD1 ROCK1 RABGAP1	5.91e-05	171	55	4	e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-mature_NK_T_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD8B DOCK10 MACF1 ATM	6.18e-05	173	55	4	36a471576a9d2325066bb14c2f2cd89c67b92915
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	RANBP2 DST GALNT3 OPHN1	6.32e-05	174	55	4	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MACC1 IFFO2 MACF1 GOLGA8A	7.05e-05	179	55	4	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	RANBP2 MACF1 ATM GOLGA8A	7.36e-05	181	55	4	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	HSPCs-Mono_prog.\|World / Lineage and Cell class	MET DOCK10 GSR LAPTM5	7.68e-05	183	55	4	1b73070baa9e5d5ada4ce25a77741630af9c1a3a
ToppCell	COVID-19_Convalescent-Lymphoid_T/NK-CD8+_T_naive\|COVID-19_Convalescent / Disease group, lineage and cell class	SFRP5 CD8B CD8B2 ATM	7.85e-05	184	55	4	0299cd30a3ea8e861a9d529043c204048ae21d29
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FNIP2 DST DOCK10 LAPTM5	7.85e-05	184	55	4	fe9ea4d0e0be820e95eaf9bb42a5560d0e177574
ToppCell	remission-CD8+_T_naive\|remission / disease stage, cell group and cell class	SFRP5 CD8B CD8B2 ATM	7.85e-05	184	55	4	fe20fa4457d4a4a75689978275b0afb5f6243faf
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-CD8_Tmem\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD8B GOLGA6L22 ATM LAPTM5	7.85e-05	184	55	4	61e2a8b9a42e5788fb4e47c77cc5de65420acbfa
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	SFRP5 CD8B CD8B2 ATM	8.01e-05	185	55	4	863a3d44c1f115942d7a2a2b63a92fe5fc768814
ToppCell	remission-CD8+_T_naive\|World / disease stage, cell group and cell class	SFRP5 CD8B CD8B2 ATM	8.01e-05	185	55	4	69304d7dd406ac7e96d51c239d7035a06d88704f
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SFRP5 CD8B CD8B2 ATM	8.01e-05	185	55	4	27dbfcd40ec832d5cf757331d8af3b5176ae90fb
ToppCell	COVID-19_Convalescent-CD8+_T_naive\|COVID-19_Convalescent / Disease condition and Cell class	SFRP5 CD8B CD8B2 ATM	8.01e-05	185	55	4	2f8277a0b58fb0c49fa76ff6dfa6da961da1f9f5
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SFRP5 CD8B CD8B2 ATM	8.01e-05	185	55	4	1c23891e4d75f99296d1304af7a9d6c3cb28d04c
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SFRP5 CD8B CD8B2 ATM	8.01e-05	185	55	4	ca8e921a6b45cd39474b9f86c95e7be023585c5d
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FNIP2 DST DOCK10 LAPTM5	8.18e-05	186	55	4	7950e03ea080238c168b9d807e217f459acdfb28
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	MTMR12 GLG1 ANKS1B PHF21A	8.35e-05	187	55	4	689b3cc76f1e04bd35a7d3ce19e9f08744a7835b
ToppCell	droplet-Lung-nan-18m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST GALNT3 DOCK10 CTTNBP2NL	8.35e-05	187	55	4	f0c6e53035b00772377c4d5f761b4d11026b911a
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MTMR12 GLG1 ANKS1B PHF21A	8.35e-05	187	55	4	4527d6426f2c4397e47f12439a13a8c14fd2aab2
ToppCell	droplet-Lung-nan-18m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST GALNT3 DOCK10 CTTNBP2NL	8.35e-05	187	55	4	f20e7a1751694390f535ffb27b97e887220f8695
ToppCell	mild_COVID-19-CD8+_T_naive\|mild_COVID-19 / disease group, cell group and cell class (v2)	SFRP5 CD8B CD8B2 ATM	8.52e-05	188	55	4	60d27014e5f9e562efe2a602482ea1d07efd0331
ToppCell	mild_COVID-19-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	SFRP5 CD8B CD8B2 ATM	8.52e-05	188	55	4	ddfb1c64305825fb0bc23819aa001bfc2ac4c2b2
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD8B DOCK10 ATM GOLGA8A	8.70e-05	189	55	4	9ab77c6fcb573854da5922412f53d2168bda6b58
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DST DOCK10 CTTNBP2NL LAPTM5	8.70e-05	189	55	4	b2542b6fcf7bc10d29158d42b03182a939ff135a
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DST DOCK10 CTTNBP2NL LAPTM5	8.88e-05	190	55	4	da58227565ad6a690828dd8554dd3670222f8582
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SFRP5 CD8B CD8B2 ATM	9.06e-05	191	55	4	696921a4f160b6b55698652488ed781e855e5e51
ToppCell	COVID-19_Moderate-CD8+_T_naive\|World / disease group, cell group and cell class	SFRP5 CD8B CD8B2 ATM	9.06e-05	191	55	4	c3385226915097f47d2f197166fc755227438524
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SFRP5 CD8B CD8B2 ATM	9.25e-05	192	55	4	ef8970e5389bd55c1624cd6dd01a7ca7abaa8950
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SFRP5 CD8B CD8B2 ATM	9.25e-05	192	55	4	ad2e0f35d50fe4e6977eba8a7a2bd990f6946305
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SFRP5 CD8B CD8B2 ATM	9.25e-05	192	55	4	284955fec5103194d416320f41fa4d87c7efc4fb
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SFRP5 CD8B CD8B2 ATM	9.25e-05	192	55	4	0d3b2b9cd586a4adbc3755563dd50b140227c287
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SFRP5 CD8B CD8B2 ATM	9.25e-05	192	55	4	67f50e5b1d449923002dc5b5d0c4d32c523034d3
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SFRP5 CD8B CD8B2 ATM	9.43e-05	193	55	4	95f5611dd9583f339b7c9f52bb478af204fb89ad
ToppCell	Control-CD8+_T_naive\|Control / Disease condition and Cell class	SFRP5 CD8B CD8B2 ATM	9.43e-05	193	55	4	627d345baf1940218c61907305705298e473dbab
ToppCell	COVID-19_Severe-CD8+_T_naive\|COVID-19_Severe / Disease condition and Cell class	SFRP5 CD8B CD8B2 ATM	9.43e-05	193	55	4	8ece109352d67b6a76bc87a2579e299c77c63137
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SFRP5 CD8B CD8B2 ATM	9.62e-05	194	55	4	7c80fd2a70ee737d52738db6ad58577a15677fc4
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DST ANKS1B DOCK10 MACF1	9.62e-05	194	55	4	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	COVID-19_Mild-CD8+_T_naive\|COVID-19_Mild / Disease condition and Cell class	SFRP5 CD8B CD8B2 ATM	9.62e-05	194	55	4	4e42df4f6db456ab914ddfb2a938dfc462f8b6bf
ToppCell	CF-Myeloid-cDC\|Myeloid / Disease state, Lineage and Cell class	MACC1 DST CDYL CTTNBP2NL	9.62e-05	194	55	4	3feb8a0ba3368673c53e9cbd4980e73d18697718
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SFRP5 CD8B CD8B2 ATM	9.62e-05	194	55	4	1154625adeafa354d8cc847e26b75f4f37e4c39f
ToppCell	COVID-19_Severe-Lymphoid_T/NK-CD8+_T_naive\|COVID-19_Severe / Disease group, lineage and cell class	SFRP5 CD8B CD8B2 ATM	9.62e-05	194	55	4	6aeedfdb2b526913937eea978ddcbab8be4e49a6
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SFRP5 CD8B CD8B2 ATM	9.62e-05	194	55	4	a1fabd408a74c2649a69e57e8865b79fdfe9047f
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SFRP5 CD8B CD8B2 ATM	9.62e-05	194	55	4	3844ef71804feef04948ff82fec4244e88fb63b2
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-Activated_CD8_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD8B CD8B2 DOCK10 LAPTM5	9.82e-05	195	55	4	a7c70284ac47dcc6f47ee2805b76b14edfa1c0b9
ToppCell	COVID_non-vent-Lymphocytic-T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	CD8B MACF1 ATM GOLGA8A	9.82e-05	195	55	4	4bdedd924564a260841a9153604026b57487c83d
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DST ANKS1B DOCK10 MACF1	9.82e-05	195	55	4	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	COVID-19_Moderate-CD8+_T_naive\|COVID-19_Moderate / disease group, cell group and cell class	SFRP5 CD8B CD8B2 ATM	9.82e-05	195	55	4	22fdc8876883c6b00049ed978260e11f02209b3a
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	CD8B MACF1 ATM GOLGA8A	1.02e-04	197	55	4	836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCell	(221)_CD8+_Naive_T_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	SFRP5 CD8B CD8B2 ATM	1.02e-04	197	55	4	59621a1f016b9f467e69bd5977ccdafa03b4ce21
ToppCell	COVID_vent-Lymphocytic-T_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	CD8B MACF1 ATM GOLGA8A	1.02e-04	197	55	4	ad702e440a74d54cfdcb8bb1c66bd8e0e71ab04e
ToppCell	(2)_NK/T-(221)_CD8+_Naive_T_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	SFRP5 CD8B CD8B2 ATM	1.02e-04	197	55	4	5943f30288d4c9a7d7ef2e85461487a229f44511
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-SELL+_CD8_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD8B CD8B2 ATM LAPTM5	1.04e-04	198	55	4	0dac00a64fe08ec6669af3ddd4b82413b673233d
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TLK2 MACF1 ATM GOLGA8A	1.06e-04	199	55	4	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	VE-CD8-CD8_2\|VE / Condition, Cell_class and T cell subcluster	SFRP5 CD8B CD8B2 ATM	1.06e-04	199	55	4	014fff8a0ebfda094a6ad76ddc0131e12a313394
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	DST SMC3 ROCK1 TTC1	1.06e-04	199	55	4	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	Control-Control-Lymphocyte-T/NK-CD8+_T_naive\|Control / Disease, condition lineage and cell class	SFRP5 CD8B ATM GOLGA8A	1.08e-04	200	55	4	906de95adc9716982ab32f216dddeb52639bad06
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD4-CD4_TRM/EMRA\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CD8B DOCK10 LAPTM5 CDC7	1.08e-04	200	55	4	283c55076133de5ce195ccad997ffddc56ed32a2
Drug	5-nitro-2-furaldehyde	LMOD1 TRIM37 GSR	2.44e-06	12	52	3	CID000012774
Drug	clofarabine	MET SMC3 ATM	1.45e-05	21	52	3	ctd:C068329
Drug	4,4'-vinylenedipyridine	DST LMOD1	3.06e-05	4	52	2	CID000083382
Drug	leuco form	TRIM37 GSR	5.09e-05	5	52	2	CID000164695
Drug	Dipyrone [5907-38-0]; Down 200; 12uM; PC3; HT_HG-U133A	MET SMC3 PAFAH2 RABGAP1 ATM	6.91e-05	188	52	5	4310_DN
Drug	4-n-hexylphenol	TRIM37 GSR	7.63e-05	6	52	2	CID000017132
Drug	4-n-heptylphenol	TRIM37 GSR	7.63e-05	6	52	2	CID000016143
Drug	Serotonin hydrochloride [153-98-0]; Down 200; 18.8uM; MCF7; HT_HG-U133A	MET PAFAH2 DOCK10 RABGAP1 ATM	8.01e-05	194	52	5	5268_DN
Drug	Benfotiamine [22457-89-2]; Down 200; 8.6uM; PC3; HT_HG-U133A	MET SMC3 CDYL RABGAP1 ATM	8.01e-05	194	52	5	4312_DN
Drug	16-phenyl tetranor Prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A	CUL2 MET SMC3 DOCK10 CDYL	8.21e-05	195	52	5	7509_DN
Drug	2-propylpentanoic acid; Down 200; 500uM; MCF7; HT_HG-U133A_EA	MET SMC3 PAFAH2 ATM ODF2	8.21e-05	195	52	5	1078_DN
Drug	Oxolinic acid [14698-29-4]; Down 200; 15.4uM; PC3; HT_HG-U133A	MET SMC3 GLG1 ODF2 GSR	8.41e-05	196	52	5	2103_DN
Drug	Flurandrenolide [1524-88-5]; Down 200; 9.2uM; PC3; HT_HG-U133A	MET MTMR12 GLG1 PAFAH2 ATM	8.41e-05	196	52	5	3679_DN
Drug	Sulfadiazine [68-35-9]; Up 200; 16uM; PC3; HT_HG-U133A	MET PAFAH2 RABGAP1 ATM GSR	8.41e-05	196	52	5	1810_UP
Drug	Bephenium hydroxynaphthoate [3818-50-6]; Down 200; 9uM; MCF7; HT_HG-U133A	SFRP5 GLG1 PAFAH2 RABGAP1 ATM	8.61e-05	197	52	5	6466_DN
Drug	Methacycline hydrochloride [3963-95-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A	CUL2 MET PAFAH2 MACF1 CDYL	8.61e-05	197	52	5	7321_DN
Drug	Diphenhydramine hydrochloride [147-24-0]; Up 200; 13.8uM; HL60; HT_HG-U133A	CUL2 PAFAH2 DOCK10 CDYL RECK	8.61e-05	197	52	5	1871_UP
Drug	Sulfathiazole [72-14-0]; Down 200; 15.6uM; HL60; HG-U133A	ROCK1 CDYL ATM TRIM37 GSR	8.82e-05	198	52	5	1963_DN
Disease	cancer (implicated_via_orthology)	LATS1 DST PSMC5 MACF1 ATM VBP1	1.06e-05	268	55	6	DOID:162 (implicated_via_orthology)
Disease	Benign neoplasm of stomach	MET ATM	4.56e-04	17	55	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	MET ATM	4.56e-04	17	55	2	C0496905
Disease	Carcinoma in situ of stomach	MET ATM	4.56e-04	17	55	2	C0154060
Disease	Stomach Carcinoma	MET ATM	7.00e-04	21	55	2	C0699791
Disease	Cerebral Astrocytoma	MET LATS1	9.96e-04	25	55	2	C0750935
Disease	Intracranial Astrocytoma	MET LATS1	9.96e-04	25	55	2	C0750936
Disease	Pilocytic Astrocytoma	MET LATS1	9.96e-04	25	55	2	C0334583
Disease	Astrocytoma	MET LATS1	9.96e-04	25	55	2	C0004114
Disease	Juvenile Pilocytic Astrocytoma	MET LATS1	9.96e-04	25	55	2	C0280783
Disease	Diffuse Astrocytoma	MET LATS1	9.96e-04	25	55	2	C0280785
Disease	Grade I Astrocytoma	MET LATS1	9.96e-04	25	55	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	MET LATS1	9.96e-04	25	55	2	C0205768
Disease	Mixed oligoastrocytoma	MET LATS1	9.96e-04	25	55	2	C0547065
Disease	Childhood Cerebral Astrocytoma	MET LATS1	9.96e-04	25	55	2	C0338070
Disease	Gemistocytic astrocytoma	MET LATS1	1.08e-03	26	55	2	C0334581
Disease	Protoplasmic astrocytoma	MET LATS1	1.08e-03	26	55	2	C0334580
Disease	Fibrillary Astrocytoma	MET LATS1	1.08e-03	26	55	2	C0334582
Disease	Anaplastic astrocytoma	MET LATS1	1.16e-03	27	55	2	C0334579
Disease	interleukin 17 measurement	ANKS1B ANKRD30A	3.21e-03	45	55	2	EFO_0008174

Protein segments in the cluster

Peptide	Gene	Start	Entry
AVAKVMQKDSEKNMS	PSMC5	386	P62195
SILKVVMKQCKNMQE	CTTNBP2NL	81	Q9P2B4
QKSIEMSMKCASQLK	CCDC112	281	Q8NEF3
CVMKMVCANKEEKVV	GSR	461	P00390
EKACQMMLDIRNEVK	ADGRF4	361	Q8IZF3
HCEQRTGKMEQMKKK	ANKRD30A	981	Q9BXX3
VSLKKKCTTQEMMSI	CCNB3	531	Q8WWL7
LKMICQQVEAIKKEM	RANBP2	811	P49792
QNACKRILMSKKTEM	RECK	226	O95980
MEELKKRMKEAPQTC	OPHN1	246	O60890
AKMRANCQKSTEQMK	ANKS1B	1086	Q7Z6G8
NAKKLMELACNMKIS	RABGAP1	796	Q9Y3P9
ETMKKVLDTCTIRMN	DCDC1	316	M0R2J8
DAQDQMRKMLCQKES	LATS1	676	O95835
KKAIEITECMEAQNM	MTMR12	371	Q9C0I1
MTACSEEEKQSMKKK	DST	5896	Q03001
MQKKKESTNSMETRF	VBP1	91	P61758
FCEKETKKLMQREMS	LMOD1	71	P29536
CVQMTKEVQKAMDDK	PFKL	351	P17858
KMDLLNDADTCRKKM	DNAH8	3336	Q96JB1
KVKQLSNSISKCMEM	PHF21A	586	Q96BD5
KCMEMKNTILARQKE	PHF21A	596	Q96BD5
MMSKETRQSKLAEAK	GOLGA6L22	1	H0YM25
APEKLDKQCEMMKAR	MACF1	3801	Q9UPN3
SKDTAVENMSKMEKC	CCNYL3	146	P0C7X3
ELMDPKCKQMITKRQ	GLG1	911	Q92896
CQKKMMEVQKKSFEE	ATM	2801	Q13315
VQTNKMVMLSCEAKI	CD8B2	31	A6NJW9
SSMKQTCKQETRMKK	GABRR3	36	A8MPY1
MSKKVSELNQLCTME	DOCK10	2036	Q96BY6
SKALVRCNMKMELEQ	CDYL	551	Q9Y232
KAISTKVMNSAVMRK	CDC7	326	O00311
VQTNKMVMLSCEAKI	CD8B	31	P10966
LSKINCEKEMNENMR	CEP126	191	Q9P2H0
SKEESRMERNMKNKN	GALNT3	46	Q14435
FESRMKKMEERVKAC	FNIP2	731	Q9P278
KKLNMLMNKNRCSSE	CCDC40	841	Q4G0X9
MDSEEAMINKLKQAC	CUL2	451	Q13617
CKNVKVISKEQVMFM	MACC1	611	Q6ZN28
TKIQEKAMKVDMDIC	IFFO2	281	Q5TF58
MRCKTRQKSEKQMEE	PPEF2	316	O14830
QTMESVNLMKKICAQ	PAFAH2	286	Q99487
FCMNMNTKANRKKLV	UPF2	591	Q9HAU5
CLKSEVKMQKGERQM	ODF2	136	Q5BJF6
MRKMSQEVCTLKEEK	GOLGA8A	276	A7E2F4
CKEALAKSEMNVNMK	MET	26	P08581
QMAEVRCMKTDVKNT	TRIM37	681	O94972
TNRQGMLLKKKEECM	SMC3	926	Q9UQE7
NKQKMNTDPMKRCLQ	SUPT20HL1	226	Q3ZLR7
QMCSSDFVVKMRIKE	SFRP5	196	Q5T4F7
IKCMNSVEEKRNSKM	LAPTM5	216	Q13571
EKDRMTENMKECLAQ	PRDM11	31	Q9NQV5
EKSKQEKMACRDKSM	TLK2	276	Q86UE8
EDSNRMTIKTKEKMN	C12orf40	511	Q86WS4
MKKRMSELCIDFNKN	NLN	191	Q9BYT8
AMAKKINQDIKCQLM	SAGE2P	526	A6NJ88
QSFQMKRCLDKNKLM	VPS35	26	Q96QK1
NEMQLKDEMEQKCRT	ROCK1	441	Q13464
MKQDKKEMAINDCSK	TTC1	166	Q99614