Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-8 ERVK-18 ERVK-19 ERVK-25 ERVK-24

3.09e-13371089GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-8 ERVK-18 ERVK-19 ERVK-25 ERVK-24

4.03e-13381089GO:0070001
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-7 NYNRIN ERVK-8

2.59e-07111084GO:0004523
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-6 RHBDF1 ERVK-7 ERVK-21 ERVK-9 F7 ERVK-8 ERVK-18 ERVK-19 ERVK-25 ERVK-24

2.15e-0543010811GO:0004175
GeneOntologyMolecularFunctionIgM binding

LILRB3 LILRA2 LILRB1

2.46e-05111083GO:0001791
GeneOntologyMolecularFunctioninhibitory MHC class I receptor activity

LILRB3 LILRA2 LILRB1

3.27e-05121083GO:0032396
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-7 NYNRIN ERVK-8

4.66e-05371084GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-7 ERVK-8 POLD4

5.18e-05381084GO:0034061
GeneOntologyMolecularFunctionpeptidase activity

ERVK-6 RHBDF1 ERVK-7 ERVK-21 ERVK-9 PRPF8 F7 ERVK-8 ERVK-18 ERVK-19 ERVK-25 ERVK-24 VCPIP1

5.25e-0565410813GO:0008233
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-7 ERVK-8

5.36e-05141083GO:0003964
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-7 SLFN13 NYNRIN ERVK-8

6.91e-05791085GO:0004521
GeneOntologyMolecularFunctionstructural molecule activity

ERVK-6 MAP1A EPB41L4B ERVK-7 ERVK-21 ERVK-9 MAGI2 HMCN1 ERVK-8 ERVK-18 ERVK-5 ERVK-19 ERVK-25 ERVK-24 MYBPC1

8.93e-0589110815GO:0005198
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-7 NYNRIN ERVK-8

1.11e-04461084GO:0016893
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

ENPP6 ERVK-6 PDE6C ERVK-7 H6PD PGAM5 SLFN13 SMPDL3A NYNRIN ERVK-8 CES3 PLCB2 PLCB3 ACP4

1.14e-0480710814GO:0016788
GeneOntologyMolecularFunctionMHC class I receptor activity

LILRB3 LILRA2 LILRB1

1.18e-04181083GO:0032393
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-6 OAS3 ERVK-7 TRNT1 ERVK-8 POLD4

1.78e-041521086GO:0016779
GeneOntologyMolecularFunctionphosphoric diester hydrolase activity

ENPP6 PDE6C SMPDL3A PLCB2 PLCB3

1.83e-04971085GO:0008081
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-7 ERVK-8

1.91e-04211083GO:0035613
GeneOntologyMolecularFunctionHLA-A specific inhibitory MHC class I receptor activity

LILRA2 LILRB1

2.87e-0451082GO:0030107
GeneOntologyMolecularFunctionHLA-B specific inhibitory MHC class I receptor activity

LILRA2 LILRB1

4.29e-0461082GO:0030109
GeneOntologyMolecularFunctionMHC class Ib protein complex binding

LILRA2 LILRB1

5.98e-0471082GO:0023025
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-6 ERVK-7 SLFN13 NYNRIN ERVK-8

8.66e-041361085GO:0004540
GeneOntologyMolecularFunctionendonuclease activity

ERVK-6 ERVK-7 SLFN13 NYNRIN ERVK-8

8.66e-041361085GO:0004519
GeneOntologyMolecularFunctionimmunoglobulin binding

LILRB3 LILRA2 LILRB1

9.65e-04361083GO:0019865
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

EPS8L2 DENND4A ARHGEF16 DENND6A RINL SOS2

1.61e-032311086GO:0005085
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

ERVK-6 CAMKK1 AXL OAS3 ERVK-7 CAMKK2 TRNT1 TIE1 CIITA SPHK1 ERVK-8 POLD4 WEE2

1.65e-0393810813GO:0016772
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

EPS8L2 DENND4A ARHGEF16 PGAM5 DENND6A NF1 RINL PLXNB1 SOS2

1.73e-035071089GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

EPS8L2 DENND4A ARHGEF16 PGAM5 DENND6A NF1 RINL PLXNB1 SOS2

1.73e-035071089GO:0030695
GeneOntologyMolecularFunctionstore-operated calcium channel activity

TRPC5 ORAI3

1.85e-03121082GO:0015279
GeneOntologyMolecularFunctionMHC class Ib protein binding

LILRA2 LILRB1

3.31e-03161082GO:0023029
GeneOntologyMolecularFunctionribosome binding

LARP1 NOMO1 NOMO2 NOMO3

4.11e-031201084GO:0043022
GeneOntologyMolecularFunctionMHC class Ib receptor activity

LILRA2 LILRB1

4.67e-03191082GO:0032394
GeneOntologyMolecularFunctionphosphoric ester hydrolase activity

ENPP6 PDE6C PGAM5 SMPDL3A PLCB2 PLCB3 ACP4

5.02e-033861087GO:0042578
GeneOntologyMolecularFunctioncell adhesion molecule binding

PRTG LILRA2 EPS8L2 LARP1 ARHGEF16 LILRB1 SVEP1 PLCB3 HCFC1

5.21e-035991089GO:0050839
GeneOntologyBiologicalProcessviral process

ERVK-6 MRC1 AXL LARP1 OAS3 ERVK-7 ERVK-21 ERVK-9 TRIM27 CIITA ERVK-8 ERVK-5 ERVK-19 ERVK-24 HCFC1

1.97e-0846410815GO:0016032
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-7 NYNRIN ERVK-8

4.90e-07131084GO:0015074
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

ERVK-6 ERVK-7 NYNRIN ERVK-8 POLD4

5.13e-06481085GO:0000731
GeneOntologyBiologicalProcessmulti-pass transmembrane protein insertion into ER membrane

NOMO1 NOMO2 NOMO3

1.15e-0591083GO:0160063
GeneOntologyBiologicalProcessnegative regulation of immune system process

HFE LILRB3 LILRA2 AXL VSIG4 OAS3 TRIM27 LILRB1 GRAMD4 SVEP1 NF1 FBXO7 FCRLB

2.61e-0563110813GO:0002683
GeneOntologyBiologicalProcesscell-cell fusion

ERVK-6 ERVK-21 ERVK-9 ERVK-8 ERVK-19

8.43e-05851085GO:0140253
GeneOntologyBiologicalProcesssyncytium formation by plasma membrane fusion

ERVK-6 ERVK-21 ERVK-9 ERVK-8 ERVK-19

8.43e-05851085GO:0000768
GeneOntologyBiologicalProcesssyncytium formation

ERVK-6 ERVK-21 ERVK-9 ERVK-8 ERVK-19

1.05e-04891085GO:0006949
GeneOntologyBiologicalProcessnegative regulation of activin receptor signaling pathway

NOMO1 MAGI2 NOMO3

1.73e-04211083GO:0032926
GeneOntologyCellularComponentmulti-pass translocon complex

NOMO1 NOMO2 NOMO3

1.13e-0591093GO:0160064
GeneOntologyCellularComponentFc-epsilon receptor I complex

LILRB3 LILRA2 LILRB1

1.13e-0591093GO:0032998
GeneOntologyCellularComponentFc receptor complex

LILRB3 LILRA2 LILRB1

2.93e-05121093GO:0032997
GeneOntologyCellularComponentER membrane insertion complex

NOMO1 NOMO2 NOMO3

4.81e-05141093GO:0072379
DomainIg-like_fold

HFE PRTG LILRB3 LILRA2 TSPOAP1 AXL VSIG4 LILRA6 LILRB1 NOMO1 LRFN2 HMCN1 TIE1 NOMO2 FCRLB USH2A HCFC1 NOMO3 PLXNB1 VSTM1 MYBPC1

1.01e-107069921IPR013783
Domain-

HFE PRTG LILRA2 TSPOAP1 AXL VSIG4 LILRB1 NOMO1 LRFN2 HMCN1 TIE1 NOMO2 FCRLB USH2A HCFC1 NOMO3 PLXNB1 VSTM1 MYBPC1

1.65e-0966399192.60.40.10
DomainIG

PRTG LILRB3 LILRA2 AXL VSIG4 LILRA6 LILRB1 LRFN2 HMCN1 TIE1 FCRLB VSTM1 MYBPC1

3.44e-074219913SM00409
DomainIg_sub

PRTG LILRB3 LILRA2 AXL VSIG4 LILRA6 LILRB1 LRFN2 HMCN1 TIE1 FCRLB VSTM1 MYBPC1

3.44e-074219913IPR003599
DomainIg-like_dom

HFE PRTG LILRB3 LILRA2 AXL VSIG4 LILRA6 LILRB1 LRFN2 HMCN1 TIE1 FCRLB VSTM1 MYBPC1

4.12e-075039914IPR007110
DomainDUF2012

NOMO1 NOMO2 NOMO3

5.76e-074993PF09430
DomainDUF2012

NOMO1 NOMO2 NOMO3

5.76e-074993IPR019008
DomainIG_LIKE

HFE PRTG LILRB3 LILRA2 AXL VSIG4 LILRA6 LILRB1 LRFN2 HMCN1 FCRLB VSTM1 MYBPC1

1.93e-064919913PS50835
DomainFN3

PRTG TSPOAP1 AXL LRFN2 TIE1 USH2A HCFC1 MYBPC1

6.32e-06185998SM00060
Domainig

LILRB3 LILRA2 AXL VSIG4 LILRA6 LILRB1 HMCN1 TIE1

7.69e-06190998PF00047
DomainImmunoglobulin

LILRB3 LILRA2 AXL VSIG4 LILRA6 LILRB1 HMCN1 TIE1

7.69e-06190998IPR013151
DomainCarb-bd-like_fold

NOMO1 NOMO2 NOMO3

7.94e-068993IPR013784
DomainFN3

PRTG TSPOAP1 AXL LRFN2 TIE1 USH2A HCFC1 MYBPC1

1.08e-05199998PS50853
DomainFN3_dom

PRTG TSPOAP1 AXL LRFN2 TIE1 USH2A HCFC1 MYBPC1

1.54e-05209998IPR003961
Domainfn3

PRTG TSPOAP1 AXL LRFN2 TIE1 USH2A MYBPC1

2.47e-05162997PF00041
DomainCarboxyPept_regulatory_dom

NOMO1 NOMO2 NOMO3

3.98e-0513993IPR014766
Domain-

NOMO1 NOMO2 NOMO3

3.98e-05139932.60.40.1120
DomainPLC-beta_C

PLCB2 PLCB3

8.32e-053992IPR014815
DomainPLC-beta_C

PLCB2 PLCB3

8.32e-053992PF08703
DomainCarboxyPept-like_regulatory

NOMO1 NOMO2 NOMO3

9.31e-0517993IPR008969
DomainPLC-beta

PLCB2 PLCB3

1.66e-044992IPR016280
DomainHoxA13_N

HOXA13 HOXC13

1.66e-044992PF12284
DomainHoxA13_N

HOXA13 HOXC13

1.66e-044992IPR022067
DomainIGc2

PRTG LILRA2 VSIG4 LILRB1 LRFN2 HMCN1 MYBPC1

2.55e-04235997SM00408
DomainIg_sub2

PRTG LILRA2 VSIG4 LILRB1 LRFN2 HMCN1 MYBPC1

2.55e-04235997IPR003598
DomainIntegrase_cat-core

ERVK-6 NYNRIN

2.75e-045992IPR001584
DomainINTEGRASE

ERVK-6 NYNRIN

2.75e-045992PS50994
DomainA1B_glyco/leuk_Ig-like_rcpt

LILRA2 LILRA6

4.11e-046992IPR016332
DomainIg_I-set

PRTG AXL VSIG4 LRFN2 HMCN1 MYBPC1

5.24e-04190996IPR013098
DomainI-set

PRTG AXL VSIG4 LRFN2 HMCN1 MYBPC1

5.24e-04190996PF07679
DomainIg_2

LILRA2 LILRB1 FCRLB VSTM1

6.11e-0473994PF13895
Domain-

SVEP1 HMCN1

1.48e-03119922.40.155.10
DomainGFP-like

SVEP1 HMCN1

1.48e-0311992IPR023413
DomainPLipase_C_Pinositol-sp_Y

PLCB2 PLCB3

2.79e-0315992IPR001711
DomainEF-hand_like

PLCB2 PLCB3

2.79e-0315992PF09279
DomainPIPLC_Y_DOMAIN

PLCB2 PLCB3

2.79e-0315992PS50008
DomainPI-PLC_fam

PLCB2 PLCB3

2.79e-0315992IPR001192
DomainPLC_EF-hand-like

PLCB2 PLCB3

2.79e-0315992IPR015359
DomainPI-PLC-Y

PLCB2 PLCB3

2.79e-0315992PF00387
DomainPLCYc

PLCB2 PLCB3

2.79e-0315992SM00149
DomainRetrov_capsid_C

ERVK-6 ZNF24 ERVK-5

3.79e-0359993IPR008916
DomainRasGAP_dom

NF1 PLXNB1

4.03e-0318992IPR001936
DomainPI-PLC-X

PLCB2 PLCB3

4.03e-0318992PF00388
DomainPLCXc

PLCB2 PLCB3

4.03e-0318992SM00148
DomainPIPLC_X_DOMAIN

PLCB2 PLCB3

4.48e-0319992PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCB2 PLCB3

4.48e-0319992IPR000909
DomainEGF

F7 SVEP1 HMCN1 TIE1

4.54e-03126994PF00008
DomainHis_PPase_superfam

PGAM5 ACP4

4.97e-0320992IPR029033
Domain-

PGAM5 ACP4

4.97e-03209923.40.50.1240
DomainC2

RAB11FIP1 MYOF PLCB2 PLCB3

5.21e-03131994PF00168
DomainRNaseH-like_dom

ERVK-6 PRPF8 NYNRIN

5.88e-0369993IPR012337
DomainC2

RAB11FIP1 MYOF PLCB2 PLCB3

6.09e-03137994SM00239
Domainzf-CCHC

ERVK-6 ERVK-5

6.54e-0323992PF00098
PathwayREACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION

ACSL3 PLCB2 PLCB3

1.72e-0511683M27317
PathwayREACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION

ACSL3 PLCB2 PLCB3

1.72e-0511683MM15035
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

CAMKK1 CAMKK2 PLCB2 PLCB3

3.59e-0539684MM14496
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

CAMKK1 CAMKK2 PLCB2 PLCB3

1.31e-0454684M26911
PathwayREACTOME_CAMK_IV_MEDIATED_PHOSPHORYLATION_OF_CREB

CAMKK1 CAMKK2

2.27e-045682MM14493
PathwayWP_S1P_RECEPTOR_SIGNAL_TRANSDUCTION

SPHK1 PLCB2 PLCB3

2.29e-0425683M39384
PathwayREACTOME_ACTIVATION_OF_RAC1_DOWNSTREAM_OF_NMDARS

CAMKK1 CAMKK2

3.40e-046682MM15662
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PLCB2 PLCB3

3.40e-046682M47548
PathwayREACTOME_OPIOID_SIGNALLING

CAMKK1 CAMKK2 PLCB2 PLCB3

3.77e-0471684MM14491
PathwayKEGG_MEDICUS_REFERENCE_CASR_PTH_SIGNALING_PATHWAY

PLCB2 PLCB3

4.74e-047682M47505
PathwayREACTOME_ACTIVATION_OF_RAC1_DOWNSTREAM_OF_NMDARS

CAMKK1 CAMKK2

4.74e-047682M27947
PathwayREACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION

PLCB2 PLCB3

6.30e-048682MM15032
PathwayREACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION

PLCB2 PLCB3

6.30e-048682M27356
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII_CAMKK_CAMKIV_CASCASDE

CAMKK1 CAMKK2

6.30e-048682M10546
PathwayREACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION

PLCB2 PLCB3

6.30e-048682MM15100
PathwayBIOCARTA_CACAM_PATHWAY

CAMKK1 CAMKK2

8.08e-049682M3412
PathwayREACTOME_OPIOID_SIGNALLING

CAMKK1 CAMKK2 PLCB2 PLCB3

9.26e-0490684M6467
PathwayKEGG_MEDICUS_REFERENCE_TAC3_TACR3_PLC_PKC_SIGNALING_PATHWAY

PLCB2 PLCB3

1.01e-0310682M47644
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB2 PLCB3

1.01e-0310682M47661
PathwayREACTOME_CAMK_IV_MEDIATED_PHOSPHORYLATION_OF_CREB

CAMKK1 CAMKK2

1.01e-0310682M26910
PathwayREACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION

PLCB2 PLCB3

1.01e-0310682M1825
PathwayREACTOME_NEURONAL_SYSTEM

CAMKK1 TSPOAP1 HCN3 CAMKK2 LRFN2 PLCB2 PLCB3

1.12e-03335687MM14503
PathwayKEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY

PLCB2 PLCB3

1.23e-0311682M47637
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB2 PLCB3

1.23e-0311682M49033
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-7 ERVK-21 ERVK-18 ERVK-19

3.02e-135111512629516
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-8 ERVK-18 ERVK-5 ERVK-19 ERVK-25 ERVK-24

5.24e-13941111021542922
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-21 ERVK-9 ERVK-8 ERVK-19

2.35e-1012111514557543
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-9 ERVK-18 ERVK-25 ERVK-24

2.51e-0918111518664271
Pubmed

Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.

NOMO1 NOMO2 NOMO3

3.16e-083111336011023
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-18 ERVK-19

3.16e-083111310516026
Pubmed

Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.

NOMO1 NOMO2 NOMO3

3.16e-083111325576386
Pubmed

Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.

NOMO1 NOMO2 NOMO3

1.26e-074111331833031
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7 ERVK-24

1.26e-074111310469592
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-5 ERVK-19

1.26e-07411137983737
Pubmed

A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.

NOMO1 NOMO2 NOMO3

1.26e-07411139267806
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-7 ERVK-5

3.15e-075111311401426
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-9 ERVK-19

6.28e-076111315063128
Pubmed

Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways.

LILRB3 LILRA2 LILRB1

6.28e-07611139079806
Pubmed

Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B.

LILRB3 LILRA2 LILRB1

6.28e-076111330068593
Pubmed

Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.

LILRB3 LILRA2 LILRB1

1.10e-067111317998301
Pubmed

Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.

PLCB2 PLCB3 SOS2

1.10e-067111330720883
Pubmed

Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes.

LILRB3 LILRA2 LILRB1

1.10e-067111319658091
Pubmed

A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.

LILRB3 LILRA2 LILRB1

1.75e-06811139548455
Pubmed

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.

NOMO1 NOMO2 NOMO3

1.75e-068111315257293
Pubmed

Substrate-driven assembly of a translocon for multipass membrane proteins.

NOMO1 NOMO2 NOMO3

2.62e-069111336261522
Pubmed

Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.

LILRB3 LILRA2 LILRB1

3.74e-0610111318802077
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-21 ERVK-19

3.74e-0610111312970426
Pubmed

An ER translocon for multi-pass membrane protein biogenesis.

NOMO1 NOMO2 NOMO3

5.12e-0611111332820719
Pubmed

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.

LILRB3 LILRA2 LILRB1

5.12e-0611111324052308
Pubmed

Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans.

LILRB3 LILRA6

1.01e-052111236449053
Pubmed

Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition.

LILRB3 LILRA2

1.01e-052111215242876
Pubmed

Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase Isoforms.

CAMKK1 CAMKK2

1.01e-052111227151216
Pubmed

The SphK1/S1P Axis Regulates Synaptic Vesicle Endocytosis via TRPC5 Channels.

TRPC5 SPHK1

1.01e-052111237185099
Pubmed

Cloning of mouse Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha distribution in the adult mouse brain.

CAMKK1 CAMKK2

1.01e-052111212654522
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

1.01e-05211129060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

1.01e-05211129460924
Pubmed

Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction.

CAMKK1 CAMKK2

1.01e-052111217213473
Pubmed

Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients.

LILRB3 LILRA6

1.01e-052111219617579
Pubmed

Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population.

LILRB3 LILRA6

1.01e-052111233526815
Pubmed

Ca2+/calmodulin kinase kinase alpha is dispensable for brain development but is required for distinct memories in male, though not in female, mice.

CAMKK1 CAMKK2

1.01e-052111217015468
Pubmed

Calcium/calmodulin kinase kinase beta has a male-specific role in memory formation.

CAMKK1 CAMKK2

1.01e-052111217207577
Pubmed

Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.

CAMKK1 CAMKK2

1.01e-052111222334678
Pubmed

Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.

CAMKK1 CAMKK2

1.01e-052111225679868
Pubmed

Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity.

ERVK-6 ERVK-18

1.01e-052111211672541
Pubmed

Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair.

LILRB3 LILRA6

1.01e-052111224096970
Pubmed

Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers.

LILRB3 LILRB1

1.01e-052111220631139
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

DENND4A CAMKK1 LARP1 RAB11FIP1 TRIM27 PGAM5 ACSL3 NF1 NYNRIN

1.38e-05446111924255178
Pubmed

A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells.

LILRB3 LILRA2 LILRB1

1.40e-051511139144225
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

SPAG1 LARP1 PRPF8 TRIM27 PGAM5 PPP1R18 TMEM131 PMF1

2.17e-05361111830344098
Pubmed

Phospholipase cbeta is critical for T cell chemotaxis.

PLCB2 PLCB3

3.02e-053111217675482
Pubmed

Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells.

CAMKK1 CAMKK2

3.02e-053111212628440
Pubmed

Next-generation sequencing to solve complex inherited retinal dystrophy: A case series of multiple genes contributing to disease in extended families.

PRPF8 USH2A

3.02e-053111228761320
Pubmed

Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.

PLCB2 PLCB3

3.02e-053111218079968
Pubmed

Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.

ERVK-6 ERVK-9

3.02e-05311129971820
Pubmed

The relative role of PLCbeta and PI3Kgamma in platelet activation.

PLCB2 PLCB3

3.02e-053111215705797
Pubmed

Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2.

PLCB2 PLCB3

3.02e-053111210748023
Pubmed

Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade.

CAMKK1 CAMKK2

3.02e-053111219864584
Pubmed

Transcriptional regulation of ILT family receptors.

LILRA2 LILRB1

3.02e-053111214662864
Pubmed

Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7.

LILRB3 LILRA2

3.02e-053111212529506
Pubmed

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.

TRPC5 PLCB2 PLCB3

4.04e-0521111330270038
Pubmed

Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic endothelial cells.

SVEP1 TIE1

6.03e-054111237338522
Pubmed

Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain.

PLCB2 PLCB3

6.03e-05411129753089
Pubmed

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction.

PLCB2 PLCB3

6.03e-054111210669417
Pubmed

Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss.

SPHK1 USH2A

6.03e-054111220502675
Pubmed

Phospholipase C-β1 potentiates glucose-stimulated insulin secretion.

PLCB2 PLCB3

6.03e-054111231268747
Pubmed

A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.

LILRB3 LILRB1

6.03e-05411129382880
Pubmed

Selection of homeotic proteins for binding to a human DNA replication origin.

HOXA13 HOXC13

6.03e-054111210835276
Pubmed

Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs.

PLCB2 PLCB3

6.03e-05411129188725
Pubmed

TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway.

TRPC5 CAMKK2

6.03e-054111228600513
Pubmed

Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase.

CAMKK1 CAMKK2

6.03e-054111210187789
Pubmed

Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells.

CAMKK1 CAMKK2

6.03e-054111212935886
Pubmed

PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq.

PLCB2 PLCB3

6.03e-054111223006664
Pubmed

Phospholipase C isozymes selectively couple to specific neurotransmitter receptors.

PLCB2 PLCB3

6.03e-05411129305844
Pubmed

Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation.

PLCB2 PLCB3

6.03e-054111215174099
Pubmed

A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis.

PLCB2 PLCB3

6.03e-054111222172670
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

SPAG1 EPS8L2 EPB41L4B LARP1 ARHGEF16 PPP1R18 PLCB3 HCFC1 VCPIP1

8.61e-05565111925468996
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

SPAG1 RHBDF1 EPB41L4B RAB11FIP1 ARHGEF16 NF1 MICAL2 PLCB3 PLXNB1

9.08e-05569111930639242
Pubmed

Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells.

LILRA2 LILRB1

1.00e-045111218787130
Pubmed

PIR-B Regulates CD4+ IL17a+ T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses.

LILRA2 LILRB1

1.00e-045111234242819
Pubmed

Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2.

PLCB2 PLCB3

1.00e-045111215611108
Pubmed

Role of PIR-B in autoimmune glomerulonephritis.

LILRA2 LILRB1

1.00e-045111220976309
Pubmed

Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo.

PLCB2 PLCB3

1.00e-045111226468229
Pubmed

Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury.

LILRA2 LILRB1

1.00e-045111220881122
Pubmed

PirB Overexpression Exacerbates Neuronal Apoptosis by Inhibiting TrkB and mTOR Phosphorylation After Oxygen and Glucose Deprivation Injury.

LILRA2 LILRB1

1.00e-045111227443384
Pubmed

The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling.

LILRA2 LILRB1

1.00e-045111215494528
Pubmed

Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses.

LILRA2 LILRB1

1.00e-045111219684158
Pubmed

PirB negatively regulates the inflammatory activation of astrocytes in a mouse model of sleep deprivation.

LILRA2 LILRB1

1.00e-045111237146940
Pubmed

PirB functions as an intrinsic suppressor in hippocampal neural stem cells.

LILRA2 LILRB1

1.00e-045111234120891
Pubmed

PirB regulates a structural substrate for cortical plasticity.

LILRA2 LILRB1

1.00e-045111224302763
Pubmed

Spatio-temporal expression of paired immunoglobulin-like receptor-B in the adult mouse brain after focal cerebral ischaemia.

LILRA2 LILRB1

1.00e-045111223927735
Pubmed

Enhancing motor learning by increasing the stability of newly formed dendritic spines in the motor cortex.

LILRA2 LILRB1

1.00e-045111234437845
Pubmed

Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus.

LILRA2 LILRB1

1.00e-045111237147336
Pubmed

Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity.

LILRA2 LILRB1

1.00e-045111233653799
Pubmed

Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury.

LILRA2 LILRB1

1.00e-045111221087927
Pubmed

Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis.

LILRA2 LILRB1

1.00e-045111220398663
Pubmed

Structure and flexibility of the extracellular region of the PirB receptor.

LILRA2 LILRB1

1.00e-045111230674550
Pubmed

Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence.

LILRA2 LILRB1

1.00e-045111223152562
Pubmed

Regulation of plasmacytoid dendritic cell responses by PIR-B.

LILRA2 LILRB1

1.00e-045111222948046
Pubmed

Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors.

LILRA2 LILRB1

1.00e-04511129054430
Pubmed

Paternal monoallelic expression of the paired immunoglobulin-like receptors PIR-A and PIR-B.

LILRA2 LILRB1

1.00e-045111210359805
Pubmed

Paired Ig-like Receptor B Inhibits IL-13-Driven Eosinophil Accumulation and Activation in the Esophagus.

LILRA2 LILRB1

1.00e-045111227324131
Pubmed

Characterization of paired Ig-like receptors in rats.

LILRA2 LILRB1

1.00e-045111210586026
Pubmed

Paired immunoglobulin-like receptor B regulates platelet activation.

LILRA2 LILRB1

1.00e-045111225075127
Pubmed

The TRPM7 channel is inactivated by PIP(2) hydrolysis.

PLCB2 PLCB3

1.00e-045111211941371
Cytoband19q13.4

LILRB3 LILRA2 LILRA6 LILRB1 ACP4

1.41e-0679110519q13.4
Cytoband16p13

CIITA NOMO3

4.36e-0413110216p13
CytobandEnsembl 112 genes in cytogenetic band chr19q13

LILRB3 LILRA2 AXL LILRA6 EML2 LILRB1 CLPTM1 ACP4 RINL VSTM1

6.03e-04119211010chr19q13
Cytoband12q24.2

OAS3 CAMKK2

6.68e-0416110212q24.2
GeneFamilyFibronectin type III domain containing

PRTG TSPOAP1 AXL LRFN2 TIE1 USH2A MYBPC1

2.80e-06160707555
GeneFamilyCD molecules|Inhibitory leukocyte immunoglobulin like receptors

LILRB3 LILRB1

1.47e-0457021182
GeneFamilyCD molecules|Activating leukocyte immunoglobulin like receptors

LILRA2 LILRA6

2.19e-0467021181
GeneFamilyImmunoglobulin like domain containing

AXL VSIG4 TIE1 FCRLB VSTM1

9.08e-04193705594
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCB2 PLCB3

2.42e-0319702832
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

PRTG LRFN2 HMCN1 MYBPC1

3.52e-03161704593
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND4A DENND6A

4.18e-0325702504
CoexpressionGSE11961_PLASMA_CELL_DAY7_VS_GERMINAL_CENTER_BCELL_DAY40_DN

H6PD PGAM5 MAGI2 HOXA13 FAM151A MICAL2 ORAI3 MYBPC1

1.06e-061991018M9393
ToppCellTracheal-10x5prime-Immune_Myeloid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 LILRB3 LILRA2 VSIG4 LILRA6 LILRB1 CIITA PLCB2

1.88e-082001018fc6aebc20ecaa67606154540a691242dc0aea867
ToppCellTracheal-10x5prime-Immune_Myeloid-Macrophage_other|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 LILRB3 LILRA2 VSIG4 LILRA6 LILRB1 CIITA PLCB2

1.88e-0820010181438b84096de9b4abe9e6213caa07f6bdff67358
ToppCellE18.5-samps-Myeloid-Macrophage-macrophage_-_intermediate_-_unactivated|E18.5-samps / Age Group, Lineage, Cell class and subclass

MRC1 LILRB3 AXL LILRA6 F7 PLCB2 RINL

8.92e-08162101760d3fe1f5cec4285b8774ff078ebcc6bfaec26ed
ToppCellE18.5-samps-Myeloid|E18.5-samps / Age Group, Lineage, Cell class and subclass

MRC1 LILRB3 AXL LILRA6 F7 PLCB2 RINL

8.92e-08162101718e4a807e25f754a69e9eaaddfde40f8de9b8512
ToppCellE18.5-samps-Myeloid-Macrophage|E18.5-samps / Age Group, Lineage, Cell class and subclass

MRC1 LILRB3 AXL LILRA6 F7 PLCB2 RINL

8.92e-0816210170970e4eda60e3f015335e2726e6d565fb2f43372
ToppCellRSV-Healthy-6|Healthy / Virus stimulation, Condition and Cluster

ATG9B EVC2 CAMKK1 PCNX3 TSPOAP1 TAF1C ORAI3

9.70e-0816410171b9c5a6dc4e09b90f92e98b81a5ee620f8479cc7
ToppCellRSV-Healthy-6|RSV / Virus stimulation, Condition and Cluster

ATG9B EVC2 CAMKK1 PCNX3 TSPOAP1 TAF1C ORAI3

9.70e-081641017ab312b8c2f828ea7331f2a340c4df81587a23b5c
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MRC1 LILRB3 VSIG4 OAS3 LILRB1 TIE1 SOS2

1.76e-07179101706d412fc096d88de168969466ce422f0ab5553b2
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Myeloid-Monocytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 LILRB3 LILRA2 VSIG4 LILRA6 LILRB1 CIITA

2.55e-071891017984b5f21e84dd8273d8437ac2a5a9de4e9484b9a
ToppCellBronchial_Brush-Immune|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

MRC1 LILRB3 LILRA2 AXL VSIG4 LILRB1 PPP1R18

3.37e-071971017b78d277a1d80ef27c11593ffc68ff8a8abae111f
ToppCellcontrol-HLA-DR+_CD83+_Monocyte|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LILRB3 LILRA2 LILRA6 OAS3 LILRB1 MYOF CIITA

3.61e-071991017f1b370d2869ad29c9d8ff41fdcc486fffa781ee2
ToppCellwk_20-22-Hematologic-Myeloid|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MRC1 LILRB3 LILRA2 VSIG4 LILRA6 LILRB1 PLCB2

3.61e-0719910170740166c51ce63edf83c4b98fce057f1440116d7
ToppCellwk_20-22-Hematologic|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MRC1 LILRB3 LILRA2 VSIG4 LILRA6 LILRB1 PLCB2

3.61e-071991017f360c75e169536578550bed79461a5947e2472b1
ToppCellSigmoid-Macrophage|Sigmoid / Region, Cell class and subclass

MRC1 LILRB3 AXL VSIG4 LILRA6 MYOF CIITA

3.73e-072001017b07ac0ff3b8530e99094678fed80f35949cafac8
ToppCellSigmoid-(6)_Macrophage|Sigmoid / shred on region, Cell_type, and subtype

MRC1 LILRB3 AXL VSIG4 LILRA6 MYOF CIITA

3.73e-0720010179e10cca4429de2c4c8c3c6cf2c9e28637a095be9
ToppCellTracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 LILRB3 VSIG4 LILRA6 LILRB1 CIITA PLCB2

3.73e-072001017a1ae299cf77580a6d1a728ee591888b6d70a19d6
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LILRB3 LILRA6 RAB11FIP1 TRNT1 CIITA

1.31e-06152101687a7116d0064a6051bdf28ce1e48bfc168273e66
ToppCellfacs-Heart-RV-18m-Myeloid-monocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LILRB3 TSPOAP1 LILRA6 FCRLB MYBPC1

1.36e-061531016af0ae08ff35f8210268457e5e15bcbe5d1f46d67
ToppCellfacs-Heart-RV-18m-Myeloid-monocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LILRB3 TSPOAP1 LILRA6 FCRLB MYBPC1

1.36e-061531016984a2d847f4376183fdbab7ebc77c1bf7d448f44
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 AXL LILRA6 RAB11FIP1 MYOF CIITA

1.70e-061591016323cb4a2416d2e6bff0a3f225d2edeae9ab7dc76
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HFE ZNF831 CIITA PLCB2 RINL PMF1

1.77e-061601016cfd005e98944817458e8ef9e0c436d77f50c1ad1
ToppCellfacs-Brain_Myeloid-Cerebellum-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 AXL LILRA6 OAS3 MYOF CIITA

1.77e-0616010161f7acdc8b08152d5817fc53bbf47b4a22d9c91b5
ToppCelldroplet-Lung-nan-3m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 AXL ARHGEF16 MYOF CIITA FCRLB

1.83e-061611016f1d3287d9cb4e0eec99b3509f5dc4b87ae8c8cc9
ToppCelldroplet-Lung-nan-3m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 AXL ARHGEF16 MYOF CIITA FCRLB

1.83e-061611016110cc7122e3c9f105a11d811d77c8a8852b9de6c
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Monocytes|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LILRB3 LILRA2 LILRA6 CIITA PLCB2 VSTM1

2.68e-061721016cf46810dd1072b6f2171e5d9530351ddc79a055b
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

MRC1 TSPOAP1 VSIG4 ARHGEF16 ARL10 SPHK1

2.78e-06173101642c911ed16fabdabef063830e8407192d8bde950
ToppCelldroplet-Liver-Npc-18m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LILRB3 AXL VSIG4 SMPDL3A PPP1R18

2.97e-06175101692a4a3fd323ee8360edd659f9e16dfddc8788e2f
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 AXL VSIG4 F7 MYOF SMPDL3A

3.06e-061761016b0b87eebcf5c994386b39ca607e17f10e9d9de74
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-Macrophages|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 LILRB3 AXL VSIG4 LILRA6 LILRB1

3.49e-0618010167af90f0e7ca001bf1fe5c860ee54c4cc8eb483bf
ToppCell367C-Fibroblasts-Fibroblast-D-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MRC1 LILRB3 VSIG4 LILRA6 CIITA VSTM1

3.84e-061831016b12b89debc9dd6396188bc8fe44f54c01c560966
ToppCell367C-Fibroblasts-Fibroblast-D|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MRC1 LILRB3 VSIG4 LILRA6 CIITA VSTM1

3.84e-06183101619cc0009f5332b6e4d4274df123eebbfc80b669a
ToppCell5'-Adult-LymphNode-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 LILRB3 LILRA2 VSIG4 LILRA6 LILRB1

3.96e-061841016ba260f8a2e6e510141a6b9c458eb0040acff0352
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Monocytes|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 LILRB3 LILRA2 VSIG4 LILRA6 VSTM1

4.08e-06185101600a991e63e9ac6de3f48a96e3be6073f90cbb442
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Monocytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 LILRB3 LILRA2 VSIG4 LILRA6 LILRB1

5.06e-06192101662eac1b8aed4fb924946b58c0237313f697a0136
ToppCell(2)_MNPs|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

MRC1 LILRB3 LILRA2 AXL VSIG4 LILRB1

5.36e-0619410169cd64e325ec233da82c463b09262efe93d2a92ee
ToppCellCOVID_vent-Myeloid-Monocytic-CD16+_Monocyte|COVID_vent / Disease condition, Lineage, Cell class and subclass

MRC1 LILRA2 VSIG4 OAS3 LILRB1 MYOF

5.36e-061941016b133d3d198360269cc449a75d34c29be377d91e0
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

MRC1 LILRB3 AXL LILRB1 CIITA PLCB2

5.52e-061951016ba7f85e5307d96ac5ad7c952f8d094db9ca1790c
ToppCell15-Trachea-Immune-Hematopoietic,_Macrophage|Trachea / Age, Tissue, Lineage and Cell class

LILRB3 LILRA2 AXL VSIG4 LILRB1 CIITA

5.52e-061951016495453b3cf08fa3c5d37ad3a2bf9c526118f9600
ToppCell10x5'v1-week_17-19-Myeloid_neutrophil-granulo-neutrophil|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LILRB3 LILRA2 LILRA6 RAB11FIP1 LILRB1 VSTM1

5.69e-061961016ad193b231ff2f7c72590fab79919c179d5d2f327
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

MRC1 LILRB3 VSIG4 LILRA6 LILRB1 CIITA

5.69e-0619610167026c1fc33425e5476063d17c79e4b79356a9e01
ToppCellNS-control-d_0-4-Myeloid-Non-resident_Macrophage|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MRC1 LILRB3 LILRA2 VSIG4 LILRB1 PPP1R18

5.86e-061971016496a1115071a1be6928786192de49f3adf197dfb
ToppCellwk_15-18-Hematologic|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

MRC1 LILRB3 LILRA2 VSIG4 LILRB1 PLCB2

5.86e-061971016ecc2f84c1f7442cad668a534e59eccc637dfbf44
ToppCellVE-mDC2-|VE / Condition, Cell_class and T cell subcluster

MRC1 LILRB3 LILRA2 AXL MYOF CIITA

5.86e-0619710166629588819ec31a7e4f33b94b8c035145a5f6c17
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 LILRB3 LILRA2 VSIG4 LILRA6 CIITA

5.86e-061971016555ea43eccc3eb22be230c27e13d8b3b64c2a61f
ToppCellVE-mDC2|VE / Condition, Cell_class and T cell subcluster

MRC1 LILRB3 LILRA2 AXL MYOF CIITA

5.86e-061971016e3172102ad17c92c3038cad37bf933eb04351048
ToppCellwk_15-18-Hematologic-Myeloid|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

MRC1 LILRB3 LILRA2 VSIG4 LILRB1 PLCB2

6.03e-061981016d5a66ed71b0a4b070b19bc3a1540c741865f3cf1
ToppCellMild-Myeloid-Macrophages-FCN1_high|Mild / Condition, Lineage, Cell class and cell subclass

LILRB3 LILRA2 LILRA6 LILRB1 MYOF SPHK1

6.03e-06198101617aab4dc3b2cd6eb7dda77dd51bdc20490fcfe19
ToppCellCaecum-(6)_Macrophage-(61)_LYVE1_Macrophage|Caecum / shred on region, Cell_type, and subtype

MRC1 LILRA2 RHBDF1 VSIG4 MYOF SMPDL3A

6.03e-061981016e684c3934c163aef4d284b69435832d2c9614f2a
ToppCellCaecum-Macrophage-LYVE1_Macrophage|Caecum / Region, Cell class and subclass

MRC1 LILRA2 RHBDF1 VSIG4 MYOF SMPDL3A

6.03e-061981016a92c0cacb775aca6bbb302bd9e22c081a112a44d
ToppCellmLN-(4)_Monocyte|mLN / shred on region, Cell_type, and subtype

LILRB3 LILRA2 VSIG4 LILRA6 SPHK1 VSTM1

6.21e-0619910166795ff31f92580195c9db776951f99d647484d24
ToppCellBAL-Mild-Myeloid|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

MRC1 LILRB3 AXL VSIG4 LILRB1 MYOF

6.21e-0619910160f0fcc6fb980167cfa9aa404b845441fb95a08f4
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 LILRB3 VSIG4 LILRB1 CIITA PLCB2

6.21e-061991016f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCellmLN-Monocyte|mLN / Region, Cell class and subclass

LILRB3 LILRA2 VSIG4 LILRA6 SPHK1 VSTM1

6.21e-061991016241f790cd5d8a9b2451333deecc826a673bae70a
ToppCellMild_COVID-19-Myeloid|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

MRC1 LILRB3 AXL VSIG4 LILRB1 MYOF

6.21e-061991016c0a9f5629db5beff7c07c9d111a7707e062d746f
ToppCellCaecum-(5)_Dendritic_cell-(50)_cDC2|Caecum / shred on region, Cell_type, and subtype

MRC1 AXL CEP295NL VSIG4 MYOF CIITA

6.21e-061991016bf8a10a9db7e8e0a6e2b53747949f442fe0e581e
ToppCellTransverse-Macrophage-LYVE1_Macrophage|Transverse / Region, Cell class and subclass

MRC1 LILRB3 AXL VSIG4 LILRA6 MYOF

6.21e-061991016facf79c256db5ae57bdb613e86ec90616a6f67ca
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Erythrophagocytic_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

MRC1 LILRA2 AXL VSIG4 MYOF SMPDL3A

6.21e-06199101678db2e3b85356ed2f08794e5a97c16a220f8a076
ToppCellmLN-Monocyte-Monocyte|mLN / Region, Cell class and subclass

LILRB3 LILRA2 VSIG4 LILRA6 SPHK1 VSTM1

6.21e-061991016dcee372774c169a3048bdaed3734b3215bf8ffad
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 LILRB3 VSIG4 LILRB1 CIITA PLCB2

6.21e-0619910165ceeed92f831d068ff4bb3994f420002338330e7
ToppCellTransverse-(6)_Macrophage-(61)_LYVE1_Macrophage|Transverse / shred on region, Cell_type, and subtype

MRC1 LILRB3 AXL VSIG4 LILRA6 MYOF

6.21e-061991016dcc2a7f4d1fa30aaaad655dd59c5a2b039d264bf
ToppCellTracheal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD14|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 LILRB3 LILRA6 LILRB1 CIITA PLCB2

6.21e-0619910161413156b7be5373fd02bbe39ec50ccfe165fa6d1
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 LILRB3 LILRA2 VSIG4 LILRA6 CIITA

6.21e-061991016a4785c1921a3de18a9190e4d674ede6a90f80004
ToppCellCaecum-Dendritic_cell-cDC2|Caecum / Region, Cell class and subclass

MRC1 AXL CEP295NL VSIG4 MYOF CIITA

6.21e-061991016944c567307082dd54dc141e93965d46f4ec8bc1f
ToppCellmLN-(4)_Monocyte-(40)_Monocyte|mLN / shred on region, Cell_type, and subtype

LILRB3 LILRA2 VSIG4 LILRA6 SPHK1 VSTM1

6.21e-061991016bcbb1eee8d79bf670dbe113094c3a292b135ce2f
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac|lymph-node_spleen / Manually curated celltypes from each tissue

MRC1 LILRA2 AXL VSIG4 MYOF SMPDL3A

6.21e-061991016c051cc3e42cfa2ec09fd8dae1172af350bb2dfcb
ToppCellTracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intermediate|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 LILRB3 LILRA2 VSIG4 LILRA6 LILRB1

6.39e-062001016700960201ae0df2c79e2907f5a0f95d73f8034fe
ToppCellTracheal-NucSeq-Immune_Myeloid|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 LILRB3 VSIG4 LILRB1 CIITA PLCB2

6.39e-062001016ad7ae5106141669b353800fece833b3cd5bdccee
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 LILRB3 VSIG4 LILRB1 CIITA PLCB2

6.39e-062001016f3dc07a7cc8cf041da8fe610d21af595818cf2d8
ToppCellTracheal-10x5prime-Immune_Myeloid-Monocytic-Monocyte_CD16|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LILRB3 LILRA2 LILRA6 LILRB1 PLCB2 VSTM1

6.39e-0620010165ea3e74687893b8ca6cb915f0f14a14d4692775c
ToppCellCaecum-(4)_Monocyte-(40)_Monocyte|Caecum / shred on region, Cell_type, and subtype

LILRB3 LILRA2 VSIG4 LILRA6 SMPDL3A VSTM1

6.39e-062001016b078058efc51f0ff4d92123b712933b32824c655
ToppCellCaecum-(4)_Monocyte|Caecum / shred on region, Cell_type, and subtype

LILRB3 LILRA2 VSIG4 LILRA6 SMPDL3A VSTM1

6.39e-0620010166bfd6ab395e09087aeedc9a7c9ada1b4b8a26194
ToppCellTracheal-10x5prime-Immune_Myeloid-Monocytic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LILRB3 LILRA2 LILRA6 LILRB1 PLCB2 VSTM1

6.39e-0620010167076b0db66c8f90c8f9ccfbc8bc0dcc82b15e5f3
ToppCellmLN-(6)_Macrophage-(61)_LYVE1_Macrophage|mLN / shred on region, Cell_type, and subtype

MRC1 LILRB3 VSIG4 LILRA6 MYOF SMPDL3A

6.39e-062001016a20f5ec61d492d8a2adf695ec304b5d57296aa8f
ToppCellCaecum-Monocyte|Caecum / Region, Cell class and subclass

LILRB3 LILRA2 VSIG4 LILRA6 SMPDL3A VSTM1

6.39e-0620010169e8d38d024a315512521b349e8ac7caa56219daf
ToppCellmLN-Macrophage-LYVE1_Macrophage|mLN / Region, Cell class and subclass

MRC1 LILRB3 VSIG4 LILRA6 MYOF SMPDL3A

6.39e-06200101689cf739a3c2f5d30e547404f2f2ec6500cd1d65d
ToppCellTracheal-NucSeq-Immune_Myeloid-Monocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 LILRB3 LILRA6 LILRB1 CIITA PLCB2

6.39e-06200101648ce43a27e78b2883e588e1a63fa5352c2deeeb7
ToppCellCaecum-Monocyte-Monocyte|Caecum / Region, Cell class and subclass

LILRB3 LILRA2 VSIG4 LILRA6 SMPDL3A VSTM1

6.39e-062001016d33619b6c721eae3ebe50fba6b9d31fa99f2248f
ToppCellMS-Multiple_Sclerosis-Myeloid-cDC|Multiple_Sclerosis / Disease, condition lineage and cell class

MRC1 LILRB3 LILRA2 AXL VSIG4 CIITA

6.39e-062001016d9e6c344c59544c87bc13d1e866491da432c9c1b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AXL VSIG4 CIITA SPHK1 POLD4 PLCB2

6.39e-06200101674ceebee9af63f8b3ec5857eff1b662752bc3862
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate|GW23 / Sample Type, Dataset, Time_group, and Cell type.

NOMO1 MICAL2 CES3 PPP1R18 PLCB3 USH2A

6.39e-062001016fe772d98c461c973dfc082e1fc50117c27ced804
ToppCelldroplet-Pancreas-Exocrine-18m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LILRB3 VSIG4 OAS3 CIITA

2.14e-051471015684e2d8d2f0516cf8b0dc53efa7efc3050bbf0d1
ToppCelldroplet-Pancreas-Exocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LILRB3 VSIG4 OAS3 CIITA

2.14e-051471015c031fad0a4e192019775809968e46da54a111d27
ToppCellfacs-Skin-nan-18m-Myeloid-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LILRB3 OAS3 F7 CIITA

2.28e-05149101523a1b95c12f2e3708dc003e13fab423e89821f11
ToppCellfacs-Skin-nan-18m-Myeloid-macrophage|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LILRB3 OAS3 F7 CIITA

2.28e-051491015c53a3226adc8fd0eaaa842b6a96442287580cbe0
ToppCellfacs-Skin-nan-18m-Myeloid|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LILRB3 OAS3 F7 CIITA

2.28e-051491015bb18a18b891af85849b9658d774053f839c9a8e1
ToppCelldroplet-Lung-3m-Hematologic-myeloid-intermediate_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HFE LILRB3 LILRA6 OAS3 SMPDL3A

2.36e-051501015b37f538ca5f976b509efe35dc81115b72b227084
ToppCelldroplet-Lung-3m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HFE LILRB3 LILRA6 OAS3 SMPDL3A

2.36e-0515010152c7518918c40e1bf679a2d4e83b472ee6f2f9df8
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_3|390C / Donor, Lineage, Cell class and subclass (all cells)

MRC1 LILRB3 VSIG4 NOMO2 FCRLB

2.51e-051521015f717aae4882e9b67e5e40f4ef5b0d35f74a89165
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

RAB11FIP1 LCT F7 HMCN1

2.57e-057510143167beedef7304697e9577270cdeacfc9743cee1
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

RAB11FIP1 LCT F7 HMCN1

2.57e-0575101470c346f92a9ac7e33fc1b9dee1dca0bf9ae0a38c
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

RAB11FIP1 LCT F7 HMCN1

2.57e-0575101426d6e54ed0a6c3ff57f6269c460177bc7b8bf979
ToppCelldroplet-Fat-SCAT-30m-Myeloid|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HFE MRC1 LILRB3 TRPC5 FCRLB

2.68e-05154101573de626b210ec5482ba89a65e784c1e77ff2894e
ToppCelldroplet-Fat-SCAT-30m-Myeloid-myeloid_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HFE MRC1 LILRB3 TRPC5 FCRLB

2.68e-05154101556fe9953e58f71626d3ddf63d340ed35dfc4ce9f
ToppCellfacs-MAT-Fat-24m-Myeloid-macrophage|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LILRB3 LILRA6 RAB11FIP1 CIITA FCRLB

2.76e-051551015d0c1608f8f6b6f4174e51d610501c707cba5e015
ToppCell10x5'-Liver-Myeloid_Mac-Intestinal_macrophages|Liver / Manually curated celltypes from each tissue

HFE MRC1 VSIG4 SMPDL3A NYNRIN

2.85e-0515610159a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MRC1 AXL OAS3 CIITA PLCB3

2.93e-051571015e9d0300361b06aec3c216f8af15f09e14b12a4da
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LILRB3 AXL VSIG4 MAGI2

3.03e-051581015d3446fc98eff09c3626b47a2c90d07cd985378b5
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MRC1 AXL OAS3 CIITA PLCB3

3.03e-051581015e9657d8960d499832f9f9b45b5a6f4388551b7e1
ToppCellCD8+_Memory_T_cell-RSV-6|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

ATG9B CAMKK1 PCNX3 TAF1C ORAI3

3.03e-0515810155ae737757a49fc96bde1e57e02066f9f65654ea1
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LILRB3 AXL VSIG4 MAGI2

3.03e-051581015df614450e10629dc9115d7365397663e82f9e48f
DrugMethocarbamol [532-03-6]; Up 200; 16.6uM; MCF7; HT_HG-U133A

HFE PDE6C MAP1A VSIG4 MAGI2 NF1 CIITA HCFC1

2.77e-0619710182274_UP
DrugSaquinavir mesylate [149845-06-7]; Up 200; 5.2uM; MCF7; HT_HG-U133A

HFE LILRA2 TSPOAP1 MYOF NF1 CES3 PLCB2 HCFC1

3.10e-0620010183549_UP
Drugglycerol-3-phosphocholine

ENPP6 PDE6C LCT TRNT1 SMPDL3A PLCB2 PLCB3

1.18e-051721017CID000000823
DrugUrsolic acid [77-52-1]; Up 200; 8.8uM; MCF7; HT_HG-U133A

HFE DENND4A MAP1A OAS3 SVEP1 NF1 PSME4

2.48e-0519310177181_UP
Drugrosiglitazone; Down 200; 10uM; HL60; HT_HG-U133A

LILRA2 MYOF MICAL2 POLD4 PLCB2 HCFC1 SOS2

2.73e-0519610171174_DN
DrugPNU-0251126 [267429-19-6]; Up 200; 1uM; MCF7; HT_HG-U133A

HFE H6PD ZNF24 PSME4 CES3 PLCB2 HCFC1

2.73e-0519610174714_UP
Drug(-)-Adenosine 3',5'-cyclic monophosphate [60-92-4]; Up 200; 12.2uM; MCF7; HT_HG-U133A

PDE6C TRPC5 EML2 GRAMD4 NF1 HCFC1 VCPIP1

2.82e-0519710173531_UP
DrugEucatropine hydrochloride [536-93-6]; Up 200; 12.2uM; HL60; HT_HG-U133A

HFE TRPC5 LCT MAGI2 CAMKK2 NF1 CIITA

2.82e-0519710172556_UP
DrugIdazoxan hydrochloride [79944-56-2]; Down 200; 16.6uM; HL60; HT_HG-U133A

HFE LILRA2 RHBDF1 SPHK1 CLPTM1 PLCB2 PLCB3

2.92e-0519810173088_DN
DrugEstradiol-17 beta [50-28-2]; Down 200; 14.6uM; HL60; HT_HG-U133A

LILRA2 VSIG4 EML2 GRAMD4 PLCB2 PLCB3 SOS2

2.92e-0519810171299_DN
DrugCloperastine hydrochloride [14984-68-0]; Down 200; 11uM; MCF7; HT_HG-U133A

HFE MSANTD2 NF1 PLCB3 HCFC1 VCPIP1 SOS2

3.01e-0519910173608_DN
DrugNifenazone [2139-47-1]; Down 200; 13uM; HL60; HG-U133A

LILRA2 LILRB1 MYOF CAMKK2 NF1 CLPTM1 HCFC1

3.01e-0519910171439_DN
Drugmilrinone

ENPP6 PDE6C TRNT1 SMPDL3A PLCB2 PLCB3

5.60e-051501016CID000004197
DrugTc-99m HMDP

HFE PMF1

5.83e-0531012CID000123801
Drugalpha-bromo-4-chlorophenylacetic acid

LILRB3 LILRA6

5.83e-0531012CID010490868
Drugl-945

LILRB3 LILRA6

5.83e-0531012CID000097919
DiseaseSchwannomatosis, Plexiform

AXL NF1

1.13e-0451002C0751374
Diseaseleukocyte immunoglobulin-like receptor subfamily A member 6 measurement

LILRB3 LILRA6

1.69e-0461002EFO_0801767
DiseaseNeurilemmoma

AXL NF1

1.69e-0461002C0027809
Diseaseleukocyte immunoglobulin-like receptor subfamily B member 3 measurement

LILRB3 LILRA6

1.69e-0461002EFO_0802705
Diseasemean arterial pressure, unipolar depression

PCNX3 ZNF831 HOXA13

1.74e-04321003EFO_0003761, EFO_0006340
Diseasecathepsin Z measurement

ZNF831 MYBPC1

3.14e-0481002EFO_0008074
Diseaseacid sphingomyelinase-like phosphodiesterase 3a measurement

SMPDL3A MYBPC1

3.14e-0481002EFO_0008013
Diseasehypertension

HFE OAS3 ZNF831 PLCB2 PLCB3 SOS2

6.35e-043071006EFO_0000537
Diseasejuvenile rheumatoid arthritis (is_implicated_in)

HFE CIITA

8.66e-04131002DOID:676 (is_implicated_in)
Diseaseleukocyte immunoglobulin-like receptor subfamily B member 1 measurement

LILRA2 LILRB1

1.16e-03151002EFO_0008208
Diseasesusceptibility to cold sores measurement

HFE TRIM27 MICAL2

1.42e-03651003EFO_0008402
Diseasevisfatin measurement

LILRB1 GRAMD4

1.50e-03171002EFO_0801230
Diseasecongenital heart disease (implicated_via_orthology)

PLCB2 HCFC1 MYBPC1

1.68e-03691003DOID:1682 (implicated_via_orthology)
Diseasetype 2 diabetes mellitus (is_implicated_in)

HFE AXL F7 SPHK1

2.77e-031711004DOID:9352 (is_implicated_in)
DiseaseNoonan Syndrome

NF1 SOS2

2.99e-03241002C0028326

Protein segments in the cluster

PeptideGeneStartEntry
APLEPSTLGSKHLPW

CEP295NL

31

Q96MC4
IISPVSGPEHPELWR

ERVK-18

216

O42043
KIISPVSGPEHPELW

ERVK-19

326

O71037
KIVSPVSGPEHPELW

ERVK-8

326

Q902F8
IISPVSGPEHPELWR

ERVK-9

326

Q9UKH3
KHWKPAEPPTVVTGS

CIITA

156

P33076
QTGDPVALPHGPEKW

DNAH10OS

51

P0CZ25
WSIVPEVSEPVEPPK

GRAMD4

276

Q6IC98
RPPGHEEPWPIVLST

ARHGEF16

61

Q5VV41
PPEVWQVLKTHPGDP

POLD4

81

Q9HCU8
EIDWIPIAHSKPTGG

MSANTD2

391

Q6P1R3
LGLEWHLPSPDPVTV

DENND4A

1621

Q7Z401
KIEPPLGWSFEPTTV

NOMO3

91

P69849
KQLAHSVVLAWEPPP

TSPOAP1

801

O95153
WVKFVPIGAPLDTPT

ORAI3

171

Q9BRQ5
VQAGHLPKPTLWAEP

LILRA2

21

Q8N149
LPKPTLWAEPGSVII

LILRA2

26

Q8N149
VLSGKPPLEGHIPTW

ARL10

96

Q8N8L6
KSPDGAHLTWEPPSV

HCFC1

1901

P51610
WPTPGEIAHKSVQPQ

LARP1

176

Q6PKG0
KIEPPLGWSFEPTTV

NOMO2

91

Q5JPE7
PTLWPETEAHVSPPL

MAP1A

2136

P78559
PSHQISPGPTWDIKR

MAGI2

1276

Q86UL8
HPWVTKNGEEPLPSE

CAMKK1

406

Q8N5S9
IWTGDSPPHVPVPEL

SMPDL3A

106

Q92484
EGSWESLPVPLHPQV

DDX55

6

Q8NHQ9
TDPVSQVVWLPEPGH

DYNC2I2

266

Q96EX3
AIKTPWPEQHVPVLF

PCNX3

971

Q9H6A9
IRPWHLVKPSDEPEP

PLXNB1

1881

O43157
GKEPAPPVAVWKGHS

PCDH8

886

O95206
IEPDPPVSHWKPEAV

PGAM5

181

Q96HS1
IKVIPTPPADHWTLI

PDE6C

331

P51160
GPWLSAAAVIHEPKP

NSG2

151

Q9Y328
KIEPPLGWSFEPTTV

NOMO1

91

Q15155
PAWRPSGIPEKDLHS

PMF1

121

Q6P1K2
WPHLSLEPIGELAPV

EVC2

1241

Q86UK5
THWAEPKSPGVPRDV

LCT

1126

P09848
VWSHPSDPLEILPSG

LILRA6

206

Q6PI73
VWSHPSDPLEILPSG

LILRB3

206

O75022
HPGLDQPLIVIWEPS

HFE

286

Q30201
LSGKPVLWEPLVHAP

HCN3

596

Q9P1Z3
KIVSPVSGPEHPELW

ERVK-7

1086

P63135
VPKFHSGWEPPVDVL

EPS8L2

416

Q9H6S3
WFPHVIQPKPEITAG

OSR1

91

Q8TAX0
PPPDITWHKDGRAIV

HMCN1

4106

Q96RW7
ALVSWKPPDGPETVV

PRTG

836

Q2VWP7
WRPIPVHTVPVAEDK

ACP4

136

Q9BZG2
WKGRPPEEEPFITHG

PLCB3

366

Q01970
AAPWHIPTIALPEGD

CEFIP

996

Q711Q0
HGPVWIESVLPGSPA

GRID2IP

296

A4D2P6
IISPVSGPEHPELWR

ERVK-24

216

P61566
KIVSPVSGPEHPELW

ERVK-25

326

P61570
KIVSPVSGPEHPELW

ERVK-6

326

Q69384
IVSPVSGPEHPELWR

ERVK-7

216

P61567
FPHVTVAPGWPEEVL

FAM151A

471

Q8WW52
TWPLEVPETEPTLGH

FBXO7

11

Q9Y3I1
APTLSPEHWKAVPPV

CHAMP1

401

Q96JM3
PEHWKAVPPVSPELR

CHAMP1

406

Q96JM3
PGEDRFKPVVPWPHV

GALNT7

61

Q86SF2
FKPVVPWPHVEGVEV

GALNT7

66

Q86SF2
NSPETKLEPPLWHAE

GCC2

1541

Q8IWJ2
VDRWPAPVPGKTLHL

DENND6A

211

Q8IWF6
ALHIPPEELSSVPWA

ATG9B

316

Q674R7
IISPVSGPEHPELWR

ERVK-21

326

P61565
IISPVSGPEHPELWR

ERVK-5

216

Q9HDB8
SAHLWKSPFPDVVPL

HOXC13

236

P31276
KLHPWVTRHGAEPLP

CAMKK2

441

Q96RR4
KIISPVSGPEHPELW

HERVK_113

326

Q902F9
EGKPLPPHVRIWDSV

EML2

131

O95834
EKPILSLHPPWTTIF

FCRLB

21

Q6BAA4
GPVVSLWPAPGKHSE

ENPP6

271

Q6UWR7
GVITTPGIIDSHPWP

CES3

256

Q6UWW8
PGIIDSHPWPLAQKI

CES3

261

Q6UWW8
VGHEPKKWPISGVLP

H6PD

761

O95479
EPLAVHTWAPTPQGL

HPS6

266

Q86YV9
EWPVPGVAPKETAEL

PPP1R18

281

Q6NYC8
PPGHLECTPESLWKE

SLFN13

401

Q68D06
LETVKAAGPWPPLHI

EPB41L4B

566

Q9H329
EEKPWRPGSPHLPHT

MICAL2

1191

O94851
WSLPKDVPAPTVSPH

NYNRIN

1456

Q9P2P1
PLVLDPADPTWNVGH

OAS3

696

Q9Y6K5
KHWAEGVTHPPKPTT

MRC1

626

P22897
EDVPQGVSPPTWTKI

USH2A

3496

O75445
KPLLQAWVSPSETHP

RAB11FIP1

1146

Q6WKZ4
PWITPPDLQEKIHIF

TRIM27

266

P14373
WSIPPFPVSGHDIRK

TRNT1

381

Q96Q11
TFESPPPPIEWHISK

SOS2

751

Q07890
PAPTKPLVLSLHGWT

TOR2A

81

Q8N2E6
VQAGHLPKPTLWAEP

LILRB1

21

Q8NHL6
HVTKDLLWEPATPGP

TAF1C

51

Q15572
PWKPGPHRVFVTQEE

F7

36

P08709
VKWPIHPSAPELAGH

RHBDF1

526

Q96CC6
PPPVQVSEKVHAASW

SVEP1

656

Q4LDE5
AQPPHLWKSTLPDVV

HOXA13

296

P31271
PPTWSEFPKGIIVHT

ACSL3

241

O95573
IVDDHTPWVKGSVPP

CLPTM1

246

O96005
PDKTTITEPHHIWPT

PRPF8

1956

Q6P2Q9
APHGVSWVKGPLSPE

RINL

206

Q6ZS11
SWVKGPLSPEVDHPG

RINL

211

Q6ZS11
PAPTKPLVLSLHGWT

TOR2A

81

Q5JU69
EGSSIPWNHLPDPEI

ZNF24

36

P17028
PPSAVPLEPSEHEWL

SOWAHA

301

Q2M3V2
PRVPAESGPGWLHKA

ST20-AS1

81

Q8NBB2
QLTWKHPEALPGPIS

TIE1

661

P35590
VPASVPLQAWHPAKE

SPAG1

586

Q07617
EKDSPPPEWDSVPVH

TMEM131

1556

Q92545
THWLPVETPEGVPLG

AXL

321

P30530
LGPPEHKPVADTHWS

NF1

1546

P21359
PILEVPESVTGPWKG

VSIG4

21

Q9Y279
SELHVPPEWLAPGGK

VCPIP1

476

Q96JH7
PSWLTPVPDSHKLTD

PSME4

376

Q14997
WKGKPPDEEPIITHG

PLCB2

361

Q00722
PPKPSLHAWPSSVVE

VSTM1

26

Q6UX27
AHLVPLEEPVPSHWT

SPHK1

236

Q9NYA1
TDLHVQGPPPTVVEW

TRPC5

391

Q9UL62
AKGTPPWTPLSNVHE

WEE2

51

P0C1S8
HSWKQPEPVSAETPG

ZNF831

831

Q5JPB2
ETGLKPPWHLGVDSL

UHRF1BP1

411

Q6BDS2
KAIGDPSPLIHWVAP

LRFN2

311

Q9ULH4
GITIPPDHKPKSWVA

MYOF

996

Q9NZM1
TPAKDWTLVETPPGE

MYBPC1

31

Q00872