Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	medium-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	3.52e-05	2	119	2	GO:0140981
GeneOntologyMolecularFunction	16-hydroxypalmitate dehydrogenase activity	CYP4A11 CYP4A22	3.52e-05	2	119	2	GO:0103002
Domain	TRYPSIN_SER	MASP1 PRSS37 PRSS33 KLK4 KLK13 TMPRSS11A	5.71e-05	106	118	6	PS00135
Domain	TRYPSIN_HIS	MASP1 PRSS37 PRSS33 KLK4 KLK13 TMPRSS11A	6.02e-05	107	118	6	PS00134
Domain	Peptidase_S1A	MASP1 PRSS37 PRSS33 KLK4 KLK13 TMPRSS11A	8.16e-05	113	118	6	IPR001314
Domain	Cadherin_tail	PCDHA12 PCDHA10 PCDHA4 PCDHA2	8.51e-05	37	118	4	PF15974
Domain	Cadherin_CBD	PCDHA12 PCDHA10 PCDHA4 PCDHA2	8.51e-05	37	118	4	IPR031904
Domain	TRYPSIN_DOM	MASP1 PRSS37 PRSS33 KLK4 KLK13 TMPRSS11A	8.99e-05	115	118	6	PS50240
Domain	Tryp_SPc	MASP1 PRSS37 PRSS33 KLK4 KLK13 TMPRSS11A	9.89e-05	117	118	6	SM00020
Domain	Trypsin	MASP1 PRSS37 PRSS33 KLK4 KLK13 TMPRSS11A	1.19e-04	121	118	6	PF00089
Domain	Trypsin_dom	MASP1 PRSS37 PRSS33 KLK4 KLK13 TMPRSS11A	1.19e-04	121	118	6	IPR001254
Domain	Peptidase_S1_PA	MASP1 PRSS37 PRSS33 KLK4 KLK13 TMPRSS11A	1.30e-04	123	118	6	IPR009003
Domain	TRYPSIN_SER	MASP1 PRSS33 KLK4 KLK13 TMPRSS11A	2.65e-04	90	118	5	IPR033116
Domain	Sushi	MASP1 CSMD3 C4BPA CSMD1	3.24e-04	52	118	4	PF00084
Domain	Quinoprotein_ADH-like_supfam	NWD1 WDR27 WDR87 WDR17	3.49e-04	53	118	4	IPR011047
Domain	CCP	MASP1 CSMD3 C4BPA CSMD1	3.75e-04	54	118	4	SM00032
Domain	WD_REPEATS_1	WSB1 NWD1 GRWD1 WDR27 TBL3 PALB2 WDR87 WDR17	3.88e-04	278	118	8	PS00678
Domain	WD_REPEATS_2	WSB1 NWD1 GRWD1 WDR27 TBL3 PALB2 WDR87 WDR17	3.97e-04	279	118	8	PS50082
Domain	WD_REPEATS_REGION	WSB1 NWD1 GRWD1 WDR27 TBL3 PALB2 WDR87 WDR17	3.97e-04	279	118	8	PS50294
Domain	SUSHI	MASP1 CSMD3 C4BPA CSMD1	4.32e-04	56	118	4	PS50923
Domain	Sushi_SCR_CCP_dom	MASP1 CSMD3 C4BPA CSMD1	4.62e-04	57	118	4	IPR000436
Domain	TRYPSIN_HIS	MASP1 PRSS33 KLK4 KLK13 TMPRSS11A	4.94e-04	103	118	5	IPR018114
Domain	WD40_repeat_dom	WSB1 NWD1 GRWD1 WDR27 TBL3 PALB2 WDR87 WDR17	6.00e-04	297	118	8	IPR017986
Domain	IGc2	MYLK KALRN MALT1 CSF1R PXDNL SIGLEC10 CDON	7.37e-04	235	118	7	SM00408
Domain	Ig_sub2	MYLK KALRN MALT1 CSF1R PXDNL SIGLEC10 CDON	7.37e-04	235	118	7	IPR003598
Domain	Cadherin_2	PCDHA12 PCDHA10 PCDHA4 PCDHA2	7.62e-04	65	118	4	PF08266
Domain	Cadherin_N	PCDHA12 PCDHA10 PCDHA4 PCDHA2	7.62e-04	65	118	4	IPR013164
Domain	-	WSB1 NWD1 GRWD1 WDR27 TBL3 PALB2 WDR87 WDR17	1.26e-03	333	118	8	2.130.10.10
Domain	WD40	WSB1 NWD1 GRWD1 WDR27 TBL3 WDR87 WDR17	1.30e-03	259	118	7	PF00400
Domain	WD40/YVTN_repeat-like_dom	WSB1 NWD1 GRWD1 WDR27 TBL3 PALB2 WDR87 WDR17	1.30e-03	335	118	8	IPR015943
Domain	WD40	WSB1 NWD1 GRWD1 WDR27 TBL3 WDR87 WDR17	1.58e-03	268	118	7	SM00320
Domain	WD40_repeat	WSB1 NWD1 GRWD1 WDR27 TBL3 WDR87 WDR17	1.72e-03	272	118	7	IPR001680
Domain	G-protein_beta_WD-40_rep	WSB1 GRWD1 TBL3 WDR17	2.07e-03	85	118	4	IPR020472
Domain	Cyt_P450_E_grp-I	CYP2F1 CYP4A11 CYP4A22	2.88e-03	45	118	3	IPR002401
Domain	CUB	MASP1 CSMD3 CSMD1	3.67e-03	49	118	3	PF00431
Domain	WD40_repeat_CS	WSB1 NWD1 GRWD1 TBL3 WDR17	3.87e-03	164	118	5	IPR019775
Domain	CUB	MASP1 CSMD3 CSMD1	3.88e-03	50	118	3	SM00042
Domain	-	MASP1 CSMD3 CSMD1	4.34e-03	52	118	3	2.60.120.290
Domain	CUB	MASP1 CSMD3 CSMD1	4.58e-03	53	118	3	PS01180
Domain	Cyt_P450_CS	CYP2F1 CYP4A11 CYP4A22	4.58e-03	53	118	3	IPR017972
Domain	AMP-bd_C	ACSM1 ACSM3	5.06e-03	17	118	2	IPR025110
Domain	AMP-binding_C	ACSM1 ACSM3	5.06e-03	17	118	2	PF13193
Domain	Cadherin_CS	PCDHA12 PCDHA10 PCDHA4 PCDHA2	5.06e-03	109	118	4	IPR020894
Domain	CUB_dom	MASP1 CSMD3 CSMD1	5.61e-03	57	118	3	IPR000859
Domain	CYTOCHROME_P450	CYP2F1 CYP4A11 CYP4A22	5.61e-03	57	118	3	PS00086
Domain	NA_NEUROTRAN_SYMP_2	SLC6A20 SLC6A5	5.67e-03	18	118	2	PS00754
Domain	CADHERIN_1	PCDHA12 PCDHA10 PCDHA4 PCDHA2	5.75e-03	113	118	4	PS00232
Domain	Cadherin	PCDHA12 PCDHA10 PCDHA4 PCDHA2	5.75e-03	113	118	4	PF00028
Domain	-	CYP2F1 CYP4A11 CYP4A22	5.89e-03	58	118	3	1.10.630.10
Domain	p450	CYP2F1 CYP4A11 CYP4A22	5.89e-03	58	118	3	PF00067
Domain	CADHERIN_2	PCDHA12 PCDHA10 PCDHA4 PCDHA2	5.93e-03	114	118	4	PS50268
Domain	-	PCDHA12 PCDHA10 PCDHA4 PCDHA2	5.93e-03	114	118	4	2.60.40.60
Domain	CA	PCDHA12 PCDHA10 PCDHA4 PCDHA2	6.11e-03	115	118	4	SM00112
Domain	Cadherin-like	PCDHA12 PCDHA10 PCDHA4 PCDHA2	6.30e-03	116	118	4	IPR015919
Domain	SNF	SLC6A20 SLC6A5	6.31e-03	19	118	2	PF00209
Domain	NA_NEUROTRAN_SYMP_1	SLC6A20 SLC6A5	6.31e-03	19	118	2	PS00610
Domain	NA_NEUROTRAN_SYMP_3	SLC6A20 SLC6A5	6.31e-03	19	118	2	PS50267
Domain	Na/ntran_symport	SLC6A20 SLC6A5	6.31e-03	19	118	2	IPR000175
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	1.91e-07	15	122	4	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	3.31e-07	17	122	4	29911975
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	4.25e-07	18	122	4	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	4.25e-07	18	122	4	10662547
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	1.45e-06	24	122	4	24698270
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	2.76e-06	28	122	4	15347688
Pubmed	Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.	TRPA1 CLEC7A MALT1	3.48e-06	9	122	3	28658621
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA12 PCDHA10 PCDHA4	6.81e-06	11	122	3	9655502
Pubmed	The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.	TRPA1 CLEC7A MALT1	1.17e-05	13	122	3	30240621
Pubmed	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.	CYP4A11 CYP4A22	1.22e-05	2	122	2	15611369
Pubmed	20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.	CYP4A11 CYP4A22	1.22e-05	2	122	2	23825080
Pubmed	Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.	CYP4A11 CYP4A22	1.22e-05	2	122	2	16691295
Pubmed	The P450 gene superfamily: recommended nomenclature.	CYP4A11 CYP4A22	1.22e-05	2	122	2	3829886
Pubmed	Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin.	ECM1 PLSCR1	1.22e-05	2	122	2	20870722
Pubmed	FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation.	THOC5 CSF1R	1.22e-05	2	122	2	10597251
Pubmed	CSMD1 exhibits antitumor activity in A375 melanoma cells through activation of the Smad pathway.	CSMD1 SMAD3	1.22e-05	2	122	2	22538441
Pubmed	Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing.	PTPN3 ALK	1.22e-05	2	122	2	22334442
Pubmed	Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.	CYP4A11 CYP4A22	1.22e-05	2	122	2	29277328
Pubmed	Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension.	ACSM1 ACSM3	1.22e-05	2	122	2	15361761
Pubmed	Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.	CYP4A11 CYP4A22	1.22e-05	2	122	2	21820496
Pubmed	Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product.	ACSM1 ACSM3	1.22e-05	2	122	2	11470804
Pubmed	Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.	CYP4A11 CYP4A22	1.22e-05	2	122	2	23641057
Pubmed	Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.	CYP4A11 CYP4A22	1.22e-05	2	122	2	20943934
Pubmed	The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.	CYP4A11 CYP4A22	1.22e-05	2	122	2	28912346
Pubmed	Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.	CYP4A11 CYP4A22	1.22e-05	2	122	2	24413902
Pubmed	The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.	CYP4A11 CYP4A22	1.22e-05	2	122	2	2766933
Pubmed	PCDHA9 as a candidate gene for amyotrophic lateral sclerosis.	PCDHA12 PCDHA10	1.22e-05	2	122	2	38467605
Pubmed	Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.	CYP4A11 CYP4A22	1.22e-05	2	122	2	8031839
Pubmed	Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.	CYP4A11 CYP4A22	1.22e-05	2	122	2	10860550
Pubmed	SUV39H1-Mediated DNMT1 is Involved in the Epigenetic Regulation of Smad3 in Cervical Cancer.	SMAD3 DNMT1	1.22e-05	2	122	2	32698743
Pubmed	Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.	CYP4A11 CYP4A22	1.22e-05	2	122	2	17112342
Pubmed	Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.	CYP4A11 CYP4A22	1.22e-05	2	122	2	11320253
Pubmed	Characterization of the CYP4A11 gene, a second CYP4A gene in humans.	CYP4A11 CYP4A22	1.22e-05	2	122	2	12464262
Pubmed	The paracaspase MALT1 is a downstream target of Smad3 and potentiates the crosstalk between TGF-β and NF-kB signaling pathways in cancer cells.	MALT1 SMAD3	1.22e-05	2	122	2	36708753
Pubmed	High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.	CYP4A11 CYP4A22	1.22e-05	2	122	2	30088983
Pubmed	Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.	CYP4A11 CYP4A22	1.22e-05	2	122	2	15066132
Pubmed	Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.	CYP4A11 CYP4A22	1.22e-05	2	122	2	19208908
Pubmed	Identification of two new members of the CSMD gene family.	CSMD3 CSMD1	3.65e-05	3	122	2	12906867
Pubmed	Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice.	CYP4A11 CYP4A22	3.65e-05	3	122	2	2354437
Pubmed	Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.	CYP4A11 CYP4A22	3.65e-05	3	122	2	8011168
Pubmed	Identification of two novel PCDHA9 mutations associated with Hirschsprung's disease.	PCDHA12 PCDHA10	3.65e-05	3	122	2	29477871
Pubmed	Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.	CYP4A11 CYP4A22	3.65e-05	3	122	2	28270609
Pubmed	The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.	CYP4A11 CYP4A22	3.65e-05	3	122	2	1991046
Pubmed	The Genetic Landscape of Hypoplastic Left Heart Syndrome.	PCDHA12 PCDHA10	3.65e-05	3	122	2	29569026
Pubmed	Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms.	CSF1R ALK	3.65e-05	3	122	2	31768065
Pubmed	Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.	CYP4A11 CYP4A22	3.65e-05	3	122	2	19713718
Pubmed	Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver.	CYP4A11 CYP4A22	3.65e-05	3	122	2	15313227
Pubmed	H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.	CYP4A11 CYP4A22	3.65e-05	3	122	2	37659685
Pubmed	Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis.	ALK DNMT1	3.65e-05	3	122	2	33310759
Pubmed	A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.	CYP4A11 CYP4A22	3.65e-05	3	122	2	9271096
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	4.93e-05	57	122	4	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	5.28e-05	58	122	4	30377227
Pubmed	Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways.	CYP4A11 ACSM1 CYP4A22 EHBP1L1 UNC5CL SLC6A20	7.17e-05	197	122	6	21386911
Pubmed	Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.	CYP4A11 CYP4A22	7.29e-05	4	122	2	8334987
Pubmed	Mapping of the azh locus to mouse chromosome 4.	CYP4A11 CYP4A22	7.29e-05	4	122	2	1552159
Pubmed	Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.	CYP4A11 CYP4A22	7.29e-05	4	122	2	10049703
Pubmed	Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine chromosomes 10, 13, 17, and 18.	ARSB CSF1R	7.29e-05	4	122	2	8094988
Pubmed	Clinically relevant variants identified in thoracic aortic aneurysm patients by research exome sequencing.	MYLK SMAD3	7.29e-05	4	122	2	26854089
Pubmed	Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking.	MYLK KALRN	7.29e-05	4	122	2	19706030
Pubmed	Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.	CYP4A11 CYP4A22	7.29e-05	4	122	2	22159897
Pubmed	Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	7.29e-05	4	122	2	21161333
Pubmed	Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2.	CLEC7A MALT1	7.29e-05	4	122	2	21283787
Pubmed	Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.	KLK4 SIGLEC10 KLK13	8.08e-05	24	122	3	15331780
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	9.87e-05	68	122	4	11230163
Pubmed	Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.	CYP4A11 CYP4A22	1.21e-04	5	122	2	8363569
Pubmed	Mouse oocytes enable LH-induced maturation of the cumulus-oocyte complex via promoting EGF receptor-dependent signaling.	SMAD3 BMP15	1.21e-04	5	122	2	20382892
Pubmed	Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	1.21e-04	5	122	2	20427718
Pubmed	Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35.	CYP4A11 CYP4A22	1.21e-04	5	122	2	7601480
Pubmed	Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease.	PCDHA12 PCDHA10	1.21e-04	5	122	2	34888534
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	1.23e-04	72	122	4	10380929
Pubmed	The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.	CYP2F1 CYP4A11 ACSM1 CYP4A22	1.23e-04	72	122	4	25124681
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	1.37e-04	74	122	4	10817752
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	1.44e-04	75	122	4	15372022
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	1.60e-04	77	122	4	10835267
Pubmed	Organization of the distal end of mouse chromosome 4.	CYP4A11 CYP4A22	1.81e-04	6	122	2	3166417
Pubmed	Mammalian fertilization: molecular aspects of gamete adhesion, exocytosis, and fusion.	ZP1 C4BPA	1.81e-04	6	122	2	9988213
Pubmed	Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism.	CYP4A11 CYP4A22	1.81e-04	6	122	2	28007964
Pubmed	Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice.	CYP4A11 CYP4A22	1.81e-04	6	122	2	11461119
Pubmed	Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells.	CYP4A11 CYP4A22	1.81e-04	6	122	2	8798505
Pubmed	Mouse uroporphyrinogen decarboxylase: cDNA cloning, expression, and mapping.	CYP4A11 CYP4A22	1.81e-04	6	122	2	8661721
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	1.86e-04	80	122	4	10716726
Pubmed	Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.	CYP4A11 CYP4A22	2.53e-04	7	122	2	12958197
Pubmed	Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.	CYP4A11 CYP4A22	2.53e-04	7	122	2	18648086
Pubmed	Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos.	MAGEL2 DNMT1	2.53e-04	7	122	2	25300248
Pubmed	Molecular mapping of the mouse db mutation.	CYP4A11 CYP4A22	2.53e-04	7	122	2	1978328
Pubmed	CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.	WSB1 CLEC7A GHRHR CSF1R	2.56e-04	87	122	4	29991678
Pubmed	NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression.	ZP1 DNMT1 BMP15	3.00e-04	37	122	3	15326356
Pubmed	Genetic mapping of six mouse peroxiredoxin genes and fourteen peroxiredoxin related sequences.	CYP4A11 CYP4A22 C4BPA	3.25e-04	38	122	3	10501973
Pubmed	Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation.	CLEC7A MALT1	3.37e-04	8	122	2	19139169
Pubmed	Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.	CYP4A11 CYP4A22	3.37e-04	8	122	2	18488193
Pubmed	The complex genetics of hypoplastic left heart syndrome.	PCDHA12 PCDHA10	3.37e-04	8	122	2	28530678
Pubmed	Microdissection and microcloning of mid-chromosome 4: genetic mapping of 41 microdissection clones.	CYP4A11 CYP4A22	3.37e-04	8	122	2	8098006
Pubmed	Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome.	CLEC7A MALT1	4.32e-04	9	122	2	22267217
Pubmed	Mapping genes encoding drug-metabolizing enzymes in recombinant inbred mice.	CYP4A11 CYP4A22	4.32e-04	9	122	2	1685137
Pubmed	The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.	CYP4A11 CYP4A22	4.32e-04	9	122	2	7678494
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP2F1 CYP4A11 CYP4A22	5.02e-04	44	122	3	12745259
Pubmed	Genetic mapping of meander tail, a mouse mutation affecting cerebellar development.	CYP4A11 CYP4A22	5.39e-04	10	122	2	2037292
Pubmed	Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription.	RNASE3 PLSCR1	6.57e-04	11	122	2	21247419
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	PCDHA12 PCDHA10 PCDHA4 PCDHA2	8.38e-04	119	122	4	28625976
Pubmed	Human tissue kallikreins: physiologic roles and applications in cancer.	KLK4 KLK13	9.28e-04	13	122	2	15192120
Interaction	PCDHA7 interactions	PCDHA12 PCDHA10 PCDHA4 PCDHA2	1.03e-06	14	117	4	int:PCDHA7
Interaction	PCDHA10 interactions	PCDHA12 PCDHA10 PCDHA4 PCDHA2	7.28e-06	22	117	4	int:PCDHA10
Cytoband	5q31	PCDHA12 PCDHA10 PCDHA4 PCDHA2	2.61e-04	115	122	4	5q31
GeneFamily	Proteases, serine	MASP1 PRSS37 PRSS33 KLK4 TMPRSS11A	1.53e-05	63	90	5	738
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	MASP1 CSMD3 C4BPA CSMD1	1.85e-04	57	90	4	1179
GeneFamily	Clustered protocadherins	PCDHA12 PCDHA10 PCDHA4 PCDHA2	2.90e-04	64	90	4	20
GeneFamily	WD repeat domain containing	WSB1 NWD1 GRWD1 WDR27 TBL3 WDR87 WDR17	3.32e-04	262	90	7	362
GeneFamily	Kallikreins	KLK4 KLK13	2.81e-03	16	90	2	616
Coexpression	OHGUCHI_LIVER_HNF4A_TARGETS_DN	MASP1 CYP2F1 CYP4A11 ACSM1 ABCC6 CYP4A22 C4BPA TIMELESS SOAT2	4.43e-07	201	122	9	MM1294
Coexpression	OHGUCHI_LIVER_HNF4A_TARGETS_DN	MASP1 CYP2F1 ACSM1 ABCC6 CYP4A22 C4BPA TIMELESS SOAT2	1.43e-06	171	122	8	M2194
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CYP4A11 XPNPEP2 ABCC6 ARSB UNC5CL CSMD1	9.13e-06	176	122	6	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLEC7A PLEKHG2 SSPOP ARSB CSF1R SIGLEC10	1.04e-05	180	122	6	66c7b02d85e32ba3e7530d0c4aff17e7525ccdd8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	NWD1 XPNPEP2 ABCC6 SLC34A1 PTPRQ CSMD1	1.07e-05	181	122	6	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CYP4A11 XPNPEP2 ABCC6 SLC34A1 SLC6A20 CSMD1	1.11e-05	182	122	6	e1e58176f533092b6b974ca1ce8b02192a6e193d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CYP4A11 XPNPEP2 ABCC6 UNC5CL SLC6A20 CSMD1	1.11e-05	182	122	6	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CYP4A11 XPNPEP2 ABCC6 SLC34A1 SLC6A20 CSMD1	1.11e-05	182	122	6	57bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CYP4A11 ABCC6 ARSB UNC5CL SLC6A20 CSMD1	1.25e-05	186	122	6	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP2F1 ACSM1 KLK13 GPAT2 SOAT2 TMPRSS11A	1.50e-05	192	122	6	44cb225392c8d07150955ecf203fbdf6021c9790
Disease	1,5 anhydroglucitol measurement	PCDHA12 PCDHA10 PCDHA4 PCDHA2	4.34e-06	29	112	4	EFO_0008009
Disease	4-hydroxyphenylacetylglutamine measurement	ACSM1 ACSM3	4.27e-05	3	112	2	EFO_0800688
Disease	indoleacetylglutamine measurement	ACSM1 ACSM3	2.12e-04	6	112	2	EFO_0800035
Disease	X-14939 measurement	CYP4A11 CYP4A22	2.12e-04	6	112	2	EFO_0800747
Disease	visceral adipose tissue measurement, body mass index	PCDHA12 PCDHA10 PCDHA4 PCDHA2	3.44e-04	87	112	4	EFO_0004340, EFO_0004765
Disease	coronary artery disease (is_implicated_in)	MYLK KALRN ABCC6 SOAT2	5.83e-04	100	112	4	DOID:3393 (is_implicated_in)
Disease	Familial thoracic aortic aneurysm and aortic dissection	MYLK SMAD3	6.30e-04	10	112	2	cv:C4707243
Disease	dimethylglycine measurement	CSMD3 ARSB SLC6A20	7.18e-04	46	112	3	EFO_0010476
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	CYP4A11 CYP4A22	7.68e-04	11	112	2	DOID:0110861 (biomarker_via_orthology)
Disease	neuroblastoma	KALRN MALT1 NYNRIN CSMD1	1.02e-03	116	112	4	EFO_0000621
Disease	pro-hydroxy-pro measurement	XPNPEP2 ALK	1.65e-03	16	112	2	EFO_0021132
Disease	neutrophil count, basophil count	PCDHA12 PCDHA10 PCDHA4 PCDHA2 DNMT1	1.67e-03	224	112	5	EFO_0004833, EFO_0005090
Disease	Dementia	CSF1R DNMT1	1.87e-03	17	112	2	C0497327
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	PALB2 MLH3	2.34e-03	19	112	2	C1333991
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	PALB2 MLH3	2.34e-03	19	112	2	C2936783
Disease	Ovarian Failure, Premature	XPNPEP2 BMP15	2.86e-03	21	112	2	C0085215
Disease	prostate cancer (is_marker_for)	KLK4 KLK13 SMAD3 DNMT1	3.00e-03	156	112	4	DOID:10283 (is_marker_for)
Disease	cervical squamous cell carcinoma (is_marker_for)	CSF1R SMAD3	3.14e-03	22	112	2	DOID:3744 (is_marker_for)
Disease	arginine measurement	CSMD1 MED23	3.43e-03	23	112	2	EFO_0020990
Disease	Asthma	TRPA1 RNASE3 DNMT1	3.54e-03	80	112	3	C0004096
Disease	DNA methylation	WDR27 PCDHA4 ARSB CNOT6L PXDNL SLC6A5 CSMD1 KLRB1	3.59e-03	656	112	8	GO_0006306
Disease	Lynch syndrome (is_implicated_in)	MLH3 SMAD3	3.73e-03	24	112	2	DOID:3883 (is_implicated_in)
Disease	Hodgkins lymphoma	KRT39 ACSM3 KLRB1	3.79e-03	82	112	3	EFO_0000183

Protein segments in the cluster

Peptide	Gene	Start	Entry
PNSCINLPDIPHASW	C4BPA	296	P04003
ICIHPQNPSLSQWFE	CCL27	76	Q9Y4X3
PNCSFLPDLWGQSSH	C9orf50	191	Q5SZB4
IGRWNVFKQQPTCPH	CFAP77	136	Q6ZQR2
LQDHKWSGQTPVCVP	CSMD1	2721	Q96PZ7
WSGIQPTCIDPAHNT	CSMD1	3201	Q96PZ7
HNWSGQLPSCVPVSC	CSMD3	2861	Q7Z407
CSPNVFWRISHGPAQ	C9orf129	156	Q5T035
QFNTLIPWCLPHTGN	DNMT1	1491	P26358
TWQPHNCQYGVLTKP	CPED1	746	A4D0V7
FVHLNQTLPWSPCSA	ADAMTS8	396	Q9UP79
FPCPPSHWLFGHIQE	CYP4A11	51	Q02928
LCPIPWPHSTGFAQV	CCDC87	206	Q9NVE4
GPRSWFSGPHLQTLC	ABHD15	96	Q6UXT9
SWFQLCAHPVLVPLG	NWD1	836	Q149M9
NFGSPPHGALQLCWS	RAB44	376	Q7Z6P3
WVPGPHQRIFQNFKC	CYP2F1	226	P24903
ATQGPLPHTCAQFWQ	PTPN3	716	P26045
ENNPPGCHIFTVSAW	PCDHA2	466	Q9Y5H9
PILGEIFQCHWTLPN	OSBPL9	456	Q96SU4
TCFPHSQPWQAALLV	KLK13	41	Q9UKR3
IINGEDCSPHSQPWQ	KLK4	31	Q9Y5K2
GPSLSCFHWPRGVQA	RADIL	656	Q96JH8
PVNFPSHFLLRWCQG	FBXO21	321	O94952
TVWLPFCGPNVIGHF	OR4C12	161	Q96R67
SCAIAGDPFPTVHWL	MYLK	741	Q15746
APQAVHCPSIIWQAP	MAGEL2	576	Q9UJ55
HWPFPDLLCQTTGAI	LPAR5	86	Q9H1C0
HWHPQCPGLLVSTAL	GRWD1	421	Q9BQ67
LQCVAVGSPIPHYQW	MALT1	246	Q9UDY8
ESGLHLPQGQFSWVP	NUDT17	146	P0C025
VNNCQPAGHVLRIPW	KRT39	41	Q6A163
LDCVWQLVHQHPPAF	MTMR12	456	Q9C0I1
CGFNPNPHLTQVKEW	BSN	201	Q9UPA5
FNLSCHVEPWVQKNP	BMP15	146	O95972
SGVFICGPSPHWLLV	CPSF1	941	Q10570
ACPPGLVHTLGNVWA	HR	281	O43593
GFHPCWPRGFSTQVL	ENTPD2	261	Q9Y5L3
WPEQHVPVLFSVFCG	PCNX3	976	Q9H6A9
SQWPCNPEKTLIGHV	PCK2	226	Q16822
VIQTWHPCLPKFTIQ	PLSCR1	206	O15162
WLLNNCHPTPGLSGI	KRTAP3-1	66	Q9BYR8
GCQPLPFATTLWGVH	MLH3	561	Q9UHC1
QWFAIQHISLNPPRC	RNASE3	36	P12724
TCLQHPWLQPHNGSY	KALRN	2931	O60229
NWASHTLSCFPGPLQ	MED23	726	Q9ULK4
ICSKAHSWQPGIQNP	EHBP1L1	51	Q8N3D4
ALTVPTQQLHWEVCP	HROB	256	Q8N3J3
HFNPCVGVLIKPSWV	PRSS37	36	A4D1T9
LIAPQWVLTAAHCFP	PRSS33	66	Q8NF86
TQACQWSPRALFHPT	CYFIP2	556	Q96F07
FWHPVVTPALVCLSQ	NOP14	561	P78316
QPFNQHLLPWVKCTT	ALDH18A1	11	P54886
VRQCNFTAWPEHGVP	PTPRQ	2191	Q9UMZ3
NNPPGCHIFTVSAWD	PCDHA10	466	Q9Y5I2
LIQIWCHPDSLQAPT	SLC34A1	301	Q06495
QCTALLPPVSDQHWS	PALB2	1146	Q86YC2
PLAWFLACSVPAVQG	PLA2G5	6	P39877
ENNPPGCHIFTVSAW	PCDHA4	466	Q9UN74
SCHAQGEPQPIITWN	PXDNL	531	A1KZ92
PHHALILCVWFGQFP	GALR2	251	O43603
QALLAHSCNWPGQAP	GASK1A	396	Q9UFP1
PVPVIQQLYHWDCGL	GUCD1	21	Q96NT3
ACWALEPTHRPTFQQ	CSF1R	891	P07333
QGWNTPQPFLHCGFL	DBF4B	596	Q8NFT6
FPCPPSHWLFGHIQE	CYP4A22	51	Q5TCH4
PNCTWFHNAQPIHPS	CDON	341	Q4KMG0
FLWSLEQHIPPCQDV	GPAT2	96	Q6NUI2
WGAHVFCVLSPLPTV	GHRHR	6	Q02643
PWIAMLSHLNGQPFC	MASP1	461	P48740
RTGLQHQIIWPCQPS	ARSB	106	P15848
SVSSVLPGCAQPWNH	IGHA2	171	P01877
LPGCAQPWNHGETFT	IGHA2	176	P01877
CLPNRQHVVYGPWNL	ECM1	181	Q16610
LQHGFLVPSPQLWTV	HELZ2	1891	Q9BYK8
PHCLFWLLQVPSTQD	FLAD1	41	Q8NFF5
PYCNTSWILAVGPHL	SLC22A14	96	Q9Y267
GQSPLPVVFLTHCNW	NYNRIN	1366	Q9P2P1
ENNPPGCHIFTVSAW	PCDHA12	466	Q9UN75
PGLEQFHVWIGIPFC	OR52H1	26	Q8NGJ2
VLWLPFCGPNVINHF	OR4C3	161	Q8NH37
HTCLFLEPPNIQLWP	MROH5	516	Q6ZUA9
PFCHLWVPVTLVAAG	HSFX1	361	Q9UBD0
QFGCATGQIPPTLWQ	RUNDC1	356	Q96C34
NSTCNPLIHGFFNPW	TAAR3P	301	Q9P1P4
PCRHSGQWYLPNATI	SSPOP	976	A2VEC9
WTGAPHLCTAPLSQQ	SSPOP	4591	A2VEC9
VCSPQPDWGPFLAQH	SLC6A5	751	Q9Y345
TQCLPTPAAWFAHHL	LMF2	206	Q9BU23
RELSWQGLHNPCPQS	LRRC56	21	Q8IYG6
FAWSQESPPCLHRIN	ABCC6	636	O95255
PWYQSNVNTLCPAIH	PIK3R6	486	Q5UE93
ITAISWCPHNPDLFA	WDR17	86	Q8IZU2
TLCFVQWPEGPKQHF	TACR3	231	P29371
QCPAISSLEWHPFTL	NOX3	326	Q9HBY0
LPWSVCPLNGNHTGY	SLC6A20	121	Q9NP91
HCPLPQATFWGLVTP	SOAT2	501	O75908
ACAHPQPVAAGPFQW	B3GNT9	386	Q6UX72
FCGWTQGTLSPHTPQ	ALK	486	Q9UM73
EPWTAGCTVFIHHLP	ACSM1	281	Q08AH1
PWIQGACVFTHHLPR	ACSM3	291	Q53FZ2
ATQENPSPNCVWIHV	CLEC7A	211	Q9BXN2
IHFPWLPALVCTGAV	CNNM1	321	Q9NRU3
WLVENNITGCPHPHI	CNOT6L	511	Q96LI5
HQEGFSIPLLWLQNC	TIMELESS	1011	Q9UNS1
PLFVEIPAHLQWQCG	TRPA1	821	O75762
VLLLHQCWGAPSANP	ZP1	451	P60852
LGPCALLPHSVVQWN	NDUFAF3	76	Q9BU61
ILQPDVHPGNCWAFQ	SUN2	591	Q9UH99
ALPEGWNQNACHPLT	RNF148	76	Q8N7C7
STPCWIELHLNGPLQ	SMAD3	391	P84022
WALPQCQLLGVFSGH	TBL3	506	Q12788
WLQLAVFCSPLVPGQ	UNC5CL	246	Q8IV45
QPVAFWCNPISGHNT	TRBV11-3	36	A0A5A6
APWCGFCPSLNHIFI	TXNDC11	716	Q6PKC3
CSQPIQPLSWHGSSL	PLEKHG2	1071	Q9H7P9
IGNFLCVHEWPVGFQ	XPNPEP2	526	O43895
VPWSQCLQNFLLHGT	WSB1	61	Q9Y6I7
QGHLGPVTAVEFCPW	WDR27	161	A2RRH5
GHLPTLCSLATPNIW	VEZT	131	Q9HBM0
ELCGPWPSHQLLTNQ	THOC5	611	Q13769
PGQPVTVICVFNWAF	SIGLEC10	156	Q96LC7
FQGAVPLPWQNCVRT	WDR87	2821	Q6ZQQ6
HQWTVSFGTKINPPL	TMPRSS11A	236	Q6ZMR5
NISAAWHLGPLPVSC	VN1R2	16	Q8NFZ6
WHLGPLPVSCFVSNK	VN1R2	21	Q8NFZ6
LPRDVCQGSPWHQFA	KLRB1	26	Q12918